Hub : Genes

FLJ44606

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0171	0.0074	5.8e-04	0.005	0.008	0.002	0.008	0.002	0.00900	8.4e-04	5.1e-02	0.0012	5.1e-02
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0242	0.0152	2.6e-03	0.026	0.016	0.006	NA	0.023	0.00051	5.7e-03	6.4e-02	NA	1.1e-03
3	TCGA	Brain Lower Grade Glioma	0.0554	0.0272	6.3e-07	0.024	0.058	0.053	NA	0.054	0.00076	3.3e-07	1.2e-06	NA	8.5e-07
4	TCGA	Testicular Germ Cell Tumors	0.1180	0.0710	4.6e-03	0.016	0.057	0.019	NA	0.005	0.08700	4.5e-03	7.1e-02	NA	2.1e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.3	0.5	1.4	-0.2	0.9	-0.1	-1.2
Bipolar Disorder or Schizophrenia	3.1	7.7	11.9	-1.9	3.4	1.9	-3.5
Depressed Affect (Nagel 2018)	0.5	1.0	1.8	0.3	-1.3	-0.4	1.4
Depression (Nagel 2018)	0.7	1.0	1.4	-1.2	1.1	1.0	-0.6
Intelligence (Savage-Jansen 2018)	2.8	8.7	14.4	2.3	-3.8	-2.3	3.2
Neuroticism (Nagel 2018)	0.1	0.3	0.9	-1.0	0.3	0.4	-0.2
Schizophrenia (2018)	4.4	9.2	13.4	-2.3	3.7	2.5	-3.5
Schizophrenia vs Biploar Disorder	3.0	3.9	9.0	-3.0	1.6	1.2	-1.6
Worry (Nagel 2018)	1.1	2.3	3.1	-1.7	1.4	1.7	-1.0
Alzheimer’s Disease (in mother)	0.4	0.5	1.0	-0.2	-0.9	-1.0	0.3
Alzheimer’s Disease (in father)	0.6	0.7	1.6	-1.3	0.2	-0.6	-0.8
Alzheimer’s Disease (including proxy)	0.5	0.7	1.2	-0.9	-0.1	-1.1	-0.8
Crohns Disease (2017)	2.0	4.3	7.8	1.3	-2.1	-2.8	1.9
Irritable Bowel Disease (IBD)	3.8	9.0	13.2	2.0	-3.2	-3.6	3.0
Ulcerative Colitis (UC)	4.7	8.9	11.7	2.1	-3.4	-3.0	3.3
Major Depression (MDD)	1.1	1.3	2.5	0.5	-1.5	-0.5	1.6
Reaction Time	1.8	3.4	4.9	-0.8	2.0	2.0	-2.2
Verbal and Numeric Reasoning (VNR)	2.5	6.1	8.5	2.5	-2.9	-2.1	2.3
Breast Cancer	0.3	0.7	1.5	-1.2	0.4	0.9	-0.7
Ovarian Cancer	0.5	0.7	1.3	-1.2	0.7	0.7	-0.7
Prostate Cancer	0.6	0.8	0.9	0.9	-0.9	-0.8	0.9
Age at First Birth	1.2	1.7	3.4	0.0	-1.4	-1.9	1.3
Bipolar Disorder (2011)	0.2	0.2	0.2	0.4	-0.5	-0.3	0.4
Body Mass Index (BMI) (2010)	2.4	3.4	6.7	-1.2	2.1	0.8	-2.6
Coronary Artery Disease (CAD)	0.1	0.2	0.6	-0.2	0.1	-0.8	0.1
Crohns Disease (2012)	0.5	0.8	2.0	0.9	-0.6	-1.4	0.5
Mean Putamen Volume	0.3	0.3	0.8	-0.0	-0.9	0.1	0.7
Fasting Glucose	0.1	0.2	0.3	-0.6	0.2	-0.4	-0.4
HbA1C	0.6	0.7	1.2	-1.1	0.6	0.8	-0.8
HDL Cholesterol	0.3	0.4	1.7	0.3	-0.1	-1.3	0.0
LDL Cholesterol	1.0	1.6	2.5	-1.3	1.6	1.2	-1.0
Lupus	0.3	0.5	1.6	-1.3	-0.4	0.2	0.3
Neuroticism (2016)	0.2	0.3	0.4	-0.5	0.7	-0.6	-0.3
Primary Biliary Cirrhosis	0.4	0.6	2.1	-1.4	-0.2	0.4	0.5
Rheumatoid Arthritis	3.6	5.0	7.1	1.5	-2.2	-2.7	2.4
Schizophrenia (2014)	4.4	9.6	13.1	-2.7	3.6	2.4	-3.6
Triglycerides	1.2	1.9	2.8	-0.6	1.4	1.7	-1.6
Type 2 Diabetes (T2D) (2012)	3.1	3.5	5.7	-2.2	1.7	0.7	-2.4
Ulcerative Colitis	2.0	2.8	4.6	1.1	-2.1	-1.1	2.1
Blood Eosinophil Count	0.1	0.7	1.0	0.9	-1.0	-0.7	0.6
Blood Platelet Count	0.7	8.3	13.1	-3.1	2.9	1.5	-3.6
Blood Red Count	0.1	1.2	2.8	0.0	-1.0	-1.7	1.0
Blood White Count	0.1	0.7	1.0	0.7	0.8	0.6	-1.0
Heel T-Score	1.2	9.2	13.3	-2.7	3.3	2.3	-3.6
BMI	0.6	3.6	6.0	2.5	-1.6	-2.1	1.2
Height	0.5	8.8	17.2	0.2	-3.2	-2.7	4.2
Waist Hip Ratio (WHR)	0.1	0.4	0.8	0.7	0.5	0.9	-0.5
Systolic Blood Pressure	1.7	8.4	15.1	-1.5	3.9	2.0	-3.5
Smoking Status	0.2	0.5	1.0	0.3	-1.0	-0.1	0.9
Allergy or Eczema	0.3	0.8	1.4	0.2	-1.2	-1.1	0.6
Cardiovascular Disease	0.2	0.6	1.2	0.4	0.9	1.1	-0.2
Hypothyroidism (self reported)	0.5	1.0	3.6	-0.1	-0.5	1.9	0.5
Respiratory disease	5.3	11.8	13.5	3.0	-3.5	-3.7	3.5
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.2	0.5	-0.2	-0.2	-0.1
Lung FEV1/FVC ratio	8.5	43.0	62.3	-5.6	7.9	4.2	-7.8
Lung FVC	0.6	3.0	5.0	1.0	-2.2	-2.2	1.2
Neuroticism	0.1	0.3	0.8	-0.9	0.3	0.2	-0.3
Chronotype (morning person)	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.3
Hair Pigment	0.0	0.7	1.3	1.2	-0.5	-0.5	1.0
Tanning	0.1	1.6	3.5	-1.9	1.1	0.6	-1.2
Hand grip strength (left)	0.3	0.7	2.0	-1.4	0.9	-0.1	-0.2
Number of treatments/medications taken	0.3	0.5	1.2	0.7	-0.5	-1.1	0.3
Average weekly spirits intake	0.3	0.4	0.6	-0.1	0.8	0.7	-0.7
Sensitivity / hurt feelings	0.6	1.1	1.6	-0.9	1.2	0.7	-1.3
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.0	0.5	0.3	-0.2
Hearing difficulty/problems: Yes	1.1	1.6	3.9	0.5	-1.2	-2.0	1.0
Relative age of first facial hair	0.5	1.0	1.3	0.8	-1.0	-1.1	1.0
Other serious medical condition/disability diagnosed by doctor	2.9	3.8	5.0	1.8	-2.0	-2.2	1.7
Ever used hormone-replacement therapy (HRT)	1.4	1.8	3.3	-0.6	1.8	0.7	-1.7
Ever had hysterectomy (womb removed)	0.5	0.6	1.4	-0.8	-0.3	-1.2	-0.4
Systolic blood pressure, automated reading	1.1	3.2	7.1	-0.5	2.7	1.3	-1.9
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	0.4	-0.3	0.9	-0.1
Angina	1.3	1.8	5.2	2.3	-0.3	-1.3	0.4
Medication for hormone replacement therapy	0.4	0.5	1.3	0.6	-0.1	-1.1	-0.4
Vitamin and mineral supplements	0.8	1.1	2.9	1.0	0.8	1.7	-0.2
Supplements: Zinc	0.4	0.4	0.7	-0.8	0.7	0.3	-0.7
Medication: Co-codamol	2.6	3.0	5.4	0.5	-2.3	-1.2	2.3
Medication: Metformin	0.3	0.5	1.0	0.1	1.0	0.6	-0.8
Diabetes (father)	0.6	0.7	1.6	0.7	-1.3	-0.3	0.7
Diabetes (mother)	0.2	0.3	0.5	0.4	0.7	0.6	-0.4
Severe depression (siblings)	0.9	1.1	3.7	-0.7	-0.1	-1.9	-0.2
Pack years adult smoking proportion	0.4	0.7	0.8	0.9	-0.8	-0.9	0.7
Impedance of leg (right)	2.4	11.4	13.8	-3.5	3.7	3.5	-2.7
Leg fat-free mass (left)	2.7	14.4	18.7	2.9	-4.1	-4.3	3.7
Trunk fat percentage	0.5	2.0	3.0	1.4	-1.3	-1.2	1.7
Hand grip strength (right)	0.7	1.9	6.7	-2.6	0.4	-0.8	-0.2
Townsend deprivation index at recruitment	0.2	0.3	1.1	0.3	-0.1	-1.1	-0.1
Current tobacco smoking	0.2	0.3	0.4	-0.5	0.5	0.2	-0.7
Average weekly fortified wine intake	0.1	0.2	0.4	-0.2	0.6	-0.5	-0.1
Maternal smoking around birth	0.9	1.4	3.5	-1.9	1.1	0.0	-0.8
Fed-up feelings	0.7	1.3	2.5	0.4	-1.6	-0.9	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.1	-1.0	0.7	0.7	-0.5
Relative age voice broke	1.0	1.5	3.1	0.8	-1.4	-0.7	1.8
Taking other prescription medications	0.7	1.1	2.4	1.0	-0.7	-1.5	0.6
Age when periods started (menarche)	0.3	0.8	2.2	-0.8	-0.4	-1.5	0.3
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.8	0.1	-0.5	-1.7	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.7	1.3	0.4	0.8	-0.4
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.8	-0.5	0.9	0.3	-0.5
Qualifications: CSEs or equivalent	0.4	0.5	0.7	-0.7	0.4	-0.9	-0.8
Serious illness, injury or assault to yourself	0.9	1.1	2.4	1.1	-0.5	-1.6	0.6
High blood pressure	0.3	0.7	2.3	1.5	-0.3	0.3	0.7
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.8	-0.0	-1.0	-1.3	0.3
Multivitamins +/- minerals	1.3	1.7	3.8	0.7	-1.2	-1.9	1.1
Stomach or abdominal pain in last month	1.5	1.8	4.2	2.0	-1.0	-1.0	1.1
Supplements: Glucosamine	0.3	0.3	0.8	-0.7	0.2	-0.1	-0.9
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.3	-0.5	-0.2	-0.0	0.5
Medication: Atenolol	0.9	1.1	2.2	-0.8	0.7	1.5	-1.0
Medication: Levothyroxine sodium	0.1	0.1	0.2	0.5	-0.4	0.3	-0.1
Sitting height	0.5	3.8	7.0	0.4	-2.2	-2.6	1.8
Chronic bronchitis/emphysema (father)	2.3	2.7	4.8	0.5	-2.2	-1.1	2.2
High blood pressure (mother)	2.3	3.2	7.6	1.5	-1.3	-2.8	1.2
Body mass index (BMI)	0.8	3.4	6.4	2.5	-1.6	-1.4	1.6
Impedance of leg (left)	2.0	10.0	12.5	-3.5	3.4	3.0	-2.6
Leg predicted mass (left)	2.7	14.3	18.7	2.9	-4.1	-4.3	3.7
Trunk fat mass	1.1	4.5	6.2	1.9	-2.1	-2.0	2.5
Waist circumference	0.4	1.5	2.4	1.5	-1.0	-1.0	1.2
Number of incorrect matches in round	1.7	2.8	4.6	2.1	-1.6	-1.7	1.0
Past tobacco smoking	2.9	5.3	9.4	-2.3	3.1	0.7	-2.5
Alcohol usually taken with meals	0.7	1.2	4.6	-2.1	-0.1	-0.2	0.1
Nervous feelings	0.3	0.6	1.0	-1.0	0.6	-0.2	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	1.6	-1.2	1.1	0.6	-1.3
Hearing difficulty/problems with background noise	0.2	0.3	0.5	-0.7	-0.3	-0.7	-0.2
Hair/balding pattern: Pattern 2	1.1	1.4	2.3	-0.5	1.5	1.0	-1.5
Had menopause	1.1	1.4	3.2	-0.4	1.8	0.2	-1.4
Had other major operations	0.2	0.2	0.4	-0.3	0.5	0.6	-0.4
Forced vital capacity (FVC)	3.3	12.8	19.2	2.0	-4.0	-4.4	3.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.7	1.3	0.5	0.4	-0.6
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.8	-0.8	-0.0	-1.7	0.1
Qualifications: None of the above	0.2	0.5	1.0	-0.3	0.7	1.0	-0.5
Financial difficulties in last 2 years	2.7	3.7	5.9	1.6	-2.4	-1.6	1.9
Mouth/teeth dental problems	0.9	1.4	2.9	-1.0	1.2	0.0	-1.7
Heart attack	0.5	0.6	1.5	-0.4	-0.6	1.2	0.7
Allergy	3.0	6.8	8.8	-2.1	3.0	2.6	-2.7
Pain all over the body in last month	0.9	1.0	3.0	0.6	-1.7	-0.6	0.5
Diabetes (self-reported)	0.0	0.1	0.1	-0.3	0.4	0.1	-0.1
Hayfever/allergic rhinitis (self-reported)	1.3	1.8	2.7	-1.2	1.0	1.4	-1.6
Medication: Ramipril	0.1	0.1	0.3	0.5	-0.3	-0.1	0.1
Medication: Simvastatin	0.3	0.5	1.6	0.5	0.3	1.3	-0.0
Fluid intelligence score	1.7	3.6	5.2	1.9	-1.8	-2.3	1.5
Illnesses of siblings	1.6	2.2	2.8	1.6	-1.7	-1.3	1.3
Neuroticism score	0.0	0.1	0.3	-0.5	0.2	0.2	-0.1
Weight	1.5	7.5	8.4	2.5	-2.8	-2.9	2.8
Impedance of arm (right)	0.5	2.3	3.8	-2.0	1.6	1.5	-0.8
Arm fat percentage (right)	0.6	2.3	4.7	2.2	-1.1	-0.7	1.6
Trunk fat-free mass	1.4	7.9	11.8	1.8	-3.0	-3.4	2.8
Hip circumference	0.6	2.6	4.0	0.8	-1.5	-2.0	1.9
Time employed in main current job	1.0	1.2	3.0	-1.7	0.8	-1.0	-0.3
Alcohol intake versus 10 years previously	0.4	0.7	0.9	0.9	-0.8	-0.7	0.8
Father’s age at death	0.9	1.2	1.4	1.2	-1.1	-1.0	1.0
Worrier / anxious feelings	0.1	0.2	0.5	-0.3	-0.0	0.1	0.7
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	5.1	0.8	-2.3	-0.9	1.8
Falls in the last year	0.6	0.9	2.2	0.9	-0.5	-1.5	0.5
Hair/balding pattern: Pattern 3	0.9	1.3	4.2	0.2	0.8	2.0	-0.6
Number of live births	1.8	2.6	5.8	-2.4	1.3	0.5	-1.6
Forced expiratory volume in 1-second (FEV1)	1.4	4.7	9.9	0.6	-2.3	-3.1	1.8
Pulse rate	0.3	0.6	0.9	-1.0	0.9	-0.6	-0.5
Happiness	0.1	0.1	0.2	0.2	0.4	0.0	-0.3
Noisy workplace	0.5	0.7	2.3	-1.5	-0.2	0.5	-0.1
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.2	0.8	-1.1	-0.5	1.5
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	1.8	1.4	-1.0	-0.5	1.2
Mouth/teeth dental problems: Dentures	0.3	0.5	0.8	0.9	-0.2	0.9	0.7
Asthma	6.6	12.9	21.2	2.8	-3.4	-4.6	3.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.5	0.3	0.1	-0.7	-0.5
Medication: Cholesterol lowering	0.7	1.1	1.7	1.2	-0.3	1.3	1.2
Depression (self-reported)	0.4	0.4	1.3	0.6	0.0	-1.1	0.2
Medication: Lansoprazole	0.1	0.1	0.3	-0.3	0.1	0.2	-0.5
Prospective memory result	0.5	0.6	1.0	-0.7	0.7	0.6	-1.0
Lung cancer (father)	0.3	0.3	0.5	0.4	0.2	0.7	-0.7
Illnesses of mother	0.6	0.7	2.0	-0.2	-0.5	1.4	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.7	5.5	0.9	-2.3	-2.2	2.0
Pulse wave Arterial Stiffness index	0.3	0.3	1.0	1.0	0.1	-0.2	0.4
Impedance of arm (left)	0.1	0.6	1.4	-1.2	0.4	1.0	0.2
Arm fat mass (right)	1.3	5.5	6.6	2.6	-2.2	-2.0	2.5
Trunk predicted mass	1.4	7.8	11.9	1.7	-3.0	-3.5	2.7
Standing height	0.9	9.0	14.7	0.2	-3.3	-3.8	3.3
Length of working week for main job	1.8	1.9	5.5	0.9	-1.1	-2.4	0.5
Exposure to tobacco smoke at home	2.1	2.4	3.8	1.4	-1.5	-1.2	1.9
Breastfed as a baby	0.4	0.6	0.9	-0.4	0.9	0.6	-0.9
Tense / ‘highly strung’	1.0	1.6	2.8	-1.7	0.9	1.1	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.3	-0.6	0.6	-1.1	0.1
Hair/balding pattern: Pattern 4	0.5	1.3	2.5	0.1	-1.3	-1.0	1.6
Birth weight of first child	1.0	1.9	2.7	-1.3	1.6	0.7	-1.6
Peak expiratory flow (PEF)	0.4	0.9	1.6	-0.6	-1.0	-1.3	0.8
Pulse wave reflection index	1.9	2.3	4.5	2.1	-1.3	-1.5	0.9
Ever highly irritable/argumentative for 2 days	1.1	1.3	1.7	-1.2	1.3	1.0	-1.1
Loud music exposure frequency	1.0	1.1	2.1	0.3	-1.5	-1.2	0.8
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.7	-0.2	0.2	0.8	0.1
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.2	0.8	-1.1	-0.6	0.9
Blood clot in the leg (DVT)	5.4	6.9	9.9	3.1	-2.8	-0.5	3.1
Medication: Paracetamol	0.1	0.2	0.4	0.5	-0.4	-0.1	0.7
Headache pain in last month	1.4	2.5	3.6	0.7	-1.9	-1.6	1.8
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	2.3	-1.0	0.1	-0.5	-1.5
Glaucoma (self-reported)	0.3	0.4	0.7	-0.4	0.7	0.5	-0.8
Gout (self-reported)	0.4	0.6	1.1	0.9	-0.1	-0.8	1.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.1	0.2	-0.4	1.0	0.3
Medication: Amlodipine	0.5	0.8	1.5	0.9	-0.6	-1.2	0.5
Medication: Ventolin 100micrograms inhaler	3.2	4.1	6.3	1.0	-2.3	-2.5	2.0
Birth weight	0.2	0.4	0.7	-0.7	0.8	0.0	-0.8
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.5	-0.2	1.2	-0.1	-1.0
High blood pressure (siblings)	0.9	1.2	1.5	-0.8	1.2	1.2	-1.1
Forced vital capacity (FVC), Best measure	3.7	13.6	19.9	2.6	-4.5	-3.7	3.8
Body fat percentage	0.3	1.3	2.1	1.5	-0.9	-0.6	1.4
Leg fat percentage (right)	0.1	0.5	1.3	1.2	0.2	0.5	0.5
Arm fat-free mass (right)	2.3	11.6	17.3	2.5	-3.5	-4.2	3.2
Exposure to tobacco smoke outside home	1.4	1.9	4.0	0.7	-1.5	0.9	2.0
Comparative body size at age 10	0.1	0.2	0.5	0.5	-0.1	0.0	-0.7
Number of full brothers	0.3	0.4	0.8	0.4	-0.9	-0.7	0.5
Worry too long after embarrassment	0.1	0.2	0.2	-0.3	-0.5	-0.5	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.2	-0.4	0.7	-1.1	-0.4
Wheeze or whistling in the chest in last year	8.6	15.3	20.1	3.9	-4.3	-2.7	4.5
Number of children fathered	0.5	0.6	1.4	0.5	-0.8	-0.3	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.0	0.2	0.5	-1.0	-0.2
Age at first live birth	0.1	0.1	0.3	0.2	0.5	0.3	-0.3
Pulse wave peak to peak time	0.2	0.3	0.8	-0.9	-0.4	-0.3	-0.2
Health satisfaction	0.2	0.2	0.6	-0.1	0.8	-0.5	-0.2
Shortness of breath walking on level ground	1.5	1.8	3.2	1.0	-1.8	-0.6	1.6
Qualifications: College or University degree	0.3	0.9	2.8	-1.7	0.3	-0.7	-0.4
Eye problems/disorders: None of the above	0.7	0.8	1.2	1.1	-0.8	-0.8	0.8
Mouth/teeth dental problems: Loose teeth	2.1	2.5	3.7	-1.9	1.8	0.8	-1.5
Emphysema/chronic bronchitis	4.3	4.8	7.8	2.0	-2.8	-0.7	2.6
Medication for pain relief, constipation, heartburn	0.8	1.5	2.4	-1.6	1.1	0.6	-1.3
Neck or shoulder pain in last month	0.1	0.2	0.4	0.0	0.5	0.1	-0.7
Medication: Blood pressure	0.3	0.5	1.0	0.9	0.2	0.5	1.0
Angina (self-reported)	1.3	1.7	5.2	2.3	-0.5	-1.1	0.5
Migraine (self-reported)	0.4	0.5	1.4	0.4	-0.5	-1.2	0.5
Medication: Ibuprofen	0.3	0.3	0.9	0.5	0.3	-0.3	-0.9
Medication: Allopurinol	0.4	0.5	1.2	-0.8	0.5	-1.1	0.3
Medication: Omeprazole	2.2	2.6	4.3	2.1	-1.2	-1.9	1.0
Medication: Seretide 50 evohaler	0.3	0.4	0.8	-0.4	-0.7	-0.9	0.3
Mean time to correctly identify matches	2.0	3.7	6.6	-1.2	2.3	1.2	-2.6
Heart disease (mother)	0.1	0.1	0.1	-0.4	-0.2	-0.3	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.2	1.1	0.6	-0.8	-0.7
Whole body fat mass	1.1	4.6	6.0	2.1	-2.0	-2.0	2.4
Leg fat mass (right)	0.6	2.5	3.5	1.9	-1.3	-1.3	1.7
Arm predicted mass (right)	2.1	10.5	15.9	2.4	-3.4	-4.0	3.0
Pulse rate, automated reading	0.3	1.0	1.5	0.7	-0.8	-1.2	1.2
Alcohol intake frequency.	0.4	1.0	1.5	-0.8	1.2	-0.7	-1.1
Comparative height size at age 10	0.3	1.4	2.8	-0.2	-1.2	-1.7	1.2
Number of full sisters	0.4	0.4	1.4	0.0	-0.5	-0.4	1.2
Suffer from ‘nerves’	4.7	7.3	9.7	-2.8	3.1	2.3	-2.6
Overall health rating	0.3	0.6	1.1	0.6	-0.4	1.1	0.8
Chest pain or discomfort	4.3	6.1	10.8	3.3	-2.2	-1.6	2.5
Had major operations	0.1	0.1	0.2	-0.1	-0.5	-0.4	-0.3
Age at last live birth	0.2	0.3	0.6	0.1	-0.5	-0.7	0.6
Family relationship satisfaction	0.7	0.9	1.4	-1.0	1.0	0.5	-1.2
Leg pain on walking	0.6	0.8	2.7	-1.6	-0.1	0.7	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	-0.6	0.2	-0.5	-0.3
Commuting to job workplace: Car/motor vehicle	0.7	0.8	3.2	-0.3	0.1	1.8	0.1
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.5	-0.5	1.0	1.2	-0.9
Medication: Aspirin	0.2	0.3	0.5	0.5	0.3	0.7	-0.4
Supplements: Vitamin C	0.9	1.0	2.5	-0.1	0.4	-1.6	-1.2
Knee pain experienced in last month	1.3	2.1	5.5	0.9	-1.0	-2.4	1.1
Hypertension (Self-reported)	0.3	0.7	2.2	1.5	0.3	0.6	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	4.8	1.1	-0.9	-2.2	0.6
Illnesses of father: Heart disease	5.4	7.5	9.9	-3.1	3.0	2.8	-1.9
Illnesses of siblings: Diabetes	0.8	1.0	3.3	-1.8	-0.1	0.7	0.2
Smoking status: Previous	4.3	6.4	10.8	2.3	-3.3	-0.7	3.0
Forced expiratory volume in 1-second (FEV1), predicted	4.1	8.6	11.8	2.5	-2.9	-3.4	2.7
Whole body fat-free mass	1.9	10.9	16.3	2.2	-3.5	-4.0	3.2
Leg fat-free mass (right)	3.1	16.6	23.3	3.0	-4.4	-4.8	3.8
Arm fat percentage (left)	0.8	3.3	5.7	2.4	-1.6	-1.0	2.0
Average weekly red wine intake	0.3	0.5	1.4	-0.7	-0.1	-1.2	-0.3
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.8	0.3	0.6	-0.8	-0.9
Mood swings	0.8	1.5	2.4	0.8	-1.5	-0.7	1.5
Loneliness, isolation	0.4	0.6	1.1	-1.0	0.4	1.0	0.0
Long-standing illness, disability or infirmity	1.0	1.5	1.9	1.0	-1.2	-1.3	1.4
Ever had bowel cancer screening	0.6	0.7	1.2	0.5	1.1	-0.8	-0.9
Diabetes diagnosed by doctor	0.5	0.9	1.7	-0.5	1.0	1.3	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	3.6	3.9	5.8	1.5	-2.1	-2.4	1.7
Friendships satisfaction	1.2	1.4	3.0	0.9	-1.3	-1.7	0.6
Qualifications: nursing, teaching	2.1	3.3	6.5	0.7	-2.4	-0.8	2.5
Commuting to job workplace: Walk	2.7	2.9	4.8	1.7	-1.6	-2.2	1.2
Eye problems/disorders: Cataract	1.4	1.6	4.0	-2.0	0.6	1.1	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.5	-0.4	-0.6	-0.2	1.2
Medication for cholesterol	0.5	0.8	1.8	-0.1	-1.0	-0.6	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.1	-0.5	-0.8	-0.1	1.1
Back pain experienced in last month	1.3	1.9	3.1	1.1	-1.1	-1.8	1.4
Mineral and other dietary supplements	0.5	0.7	1.5	0.8	-0.5	0.7	1.2
Breast cancer (self-reported)	0.4	0.5	1.3	-1.1	0.3	0.5	-0.7
Asthma (self-reported)	6.2	12.4	19.6	2.8	-3.3	-4.4	3.3
Osteoporosis (self-reported)	1.4	1.7	5.5	2.3	-0.8	0.3	0.7
Osteoarthritis (self-reported)	0.6	0.8	2.3	1.5	-0.5	0.0	0.9
Medication: Aspirin	0.2	0.3	0.4	0.3	0.6	0.6	-0.5
Medication: Gliclazide	1.1	1.3	2.0	1.4	1.3	-0.3	-1.1
Illnesses of father: None of the above (group 1)	1.1	1.4	3.2	1.2	-0.9	-1.8	0.3
Smoking status: Current	0.4	0.6	1.1	-0.7	0.8	0.1	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.0	-1.0	0.9	0.9	-1.0
Whole body water mass	2.0	11.3	17.0	2.3	-3.5	-4.1	3.2
Leg predicted mass (right)	3.2	17.2	24.5	3.1	-4.5	-5.0	3.8
Arm fat mass (left)	1.3	5.3	6.3	2.5	-2.2	-1.9	2.5
Number of self-reported non-cancer illnesses	1.2	2.1	4.8	2.2	-1.0	-0.9	1.3
Average weekly champagne plus white wine intake	1.7	2.3	4.4	1.4	-1.7	0.1	2.1
Miserableness	0.5	0.8	1.7	0.0	-1.2	-0.4	1.3
Guilty feelings	1.0	1.5	2.1	-1.1	1.4	-0.9	-1.4
Wears glasses or contact lenses	0.3	0.3	0.9	0.6	-0.2	-1.0	-0.3
Ever taken oral contraceptive pill	0.7	0.8	1.9	0.4	-1.1	-0.4	1.4
Hearing aid user	0.1	0.1	0.3	-0.2	-0.3	0.3	0.6
Mother’s age at death	0.4	0.5	1.3	1.2	0.1	-0.9	0.3
Financial situation satisfaction	0.2	0.3	0.8	0.1	-0.9	0.2	0.5
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.7	-0.9	0.8	0.3	-0.6
Commuting to job workplace: Public transport	0.4	0.4	1.2	0.7	-0.1	-1.1	0.1
Eye problems/disorders: Glaucoma	0.1	0.2	0.3	-0.6	0.2	0.5	-0.1
Medication: Blood pressure	0.4	0.8	1.4	0.6	0.9	0.8	-1.2
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	0.6	-0.3	-0.7	-0.1
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.8	-0.8	0.2	-0.6	-0.9
High cholesterol (Self-reported)	0.7	1.2	4.2	0.3	0.6	2.0	-0.2
Medication: Bendroflumethiazide	0.1	0.1	0.2	0.5	0.1	0.2	-0.2
Medication: Paracetamol	0.2	0.4	0.6	0.6	-0.8	0.2	0.6
Medication: Lisinopril	1.1	1.4	2.8	-1.2	1.2	0.2	-1.7
Medication: Atorvastatin	0.1	0.1	0.1	0.2	-0.3	0.3	0.3
Illnesses of father: High blood pressure	0.6	0.7	1.7	0.6	-0.9	-0.1	1.3
Alcohol drinker status: Never	0.3	0.3	0.9	0.3	-0.4	-0.9	-0.4
Ever smoked	1.9	3.4	5.7	1.9	-2.4	-0.8	1.9
Basal metabolic rate	1.9	10.8	15.2	2.4	-3.4	-3.9	3.2
Leg fat percentage (left)	0.1	0.5	1.4	1.2	-0.2	0.2	0.8
Arm fat-free mass (left)	1.6	7.9	13.3	2.0	-2.8	-3.6	2.5
Number of operations (self-reported)	0.3	0.4	1.0	-1.0	0.2	0.6	-0.4
Average weekly beer plus cider intake	0.1	0.2	0.6	0.7	-0.1	0.0	-0.4
Irritability	0.3	0.5	1.3	0.4	-1.1	-0.2	0.7
Risk taking	0.3	0.4	1.2	-1.1	0.4	0.2	-0.4
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.5	0.6	-0.4	-0.2	1.2
Fractured/broken bones in last 5 years	1.4	1.9	2.5	0.9	-1.4	-1.4	1.6
Age started oral contraceptive pill	1.0	1.2	4.0	-2.0	0.6	0.3	-0.6
Diastolic blood pressure, automated reading	0.5	1.6	4.5	0.6	2.1	0.6	-1.1
Ever depressed for a whole week	1.6	1.9	3.1	-1.8	1.5	-0.9	-1.2
Unable to work because of sickness or disability	0.3	0.4	1.0	-0.3	-0.6	1.0	0.3
Commuting to job workplace: Cycle	0.6	0.8	1.4	1.0	-1.2	-0.8	0.4
Myopia	0.4	0.6	1.1	0.8	-0.4	-1.1	0.7
Vascular/heart problems diagnosed by doctor	0.5	1.4	4.0	-2.0	0.7	-0.2	-1.0
Cholesterol lowering medication	1.3	1.9	2.9	-1.1	1.2	1.7	-1.4
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	3.8	1.6	-1.3	-2.0	1.3
Pain experienced in last month	2.8	4.6	7.1	-1.6	2.1	2.7	-2.0
Supplements: Calcium	1.3	1.4	2.4	0.6	-1.2	-1.2	1.5
Basal cell carcinoma (self-reported)	0.5	0.6	1.3	-0.8	-0.3	0.8	1.1
Heart attack/myocardial infarction (self-reported)	0.6	0.7	2.3	-0.7	-0.2	1.5	0.3
Deep venous thrombosis (DVT) (self-reported)	6.9	8.8	13.5	3.7	-3.1	-1.1	3.3
Heart disease (siblings)	3.4	4.2	7.6	-2.2	1.8	2.8	-1.1
Alcohol drinker status: Previous	2.1	2.3	3.9	-0.3	2.0	-1.4	-1.8
Pack years of smoking	0.1	0.2	0.3	0.6	-0.3	-0.4	0.3
Impedance of whole body	0.9	4.4	8.0	-2.8	2.1	1.9	-1.3
Leg fat mass (left)	0.7	2.8	3.6	1.9	-1.4	-1.4	1.8
Arm predicted mass (left)	1.5	7.7	12.0	2.0	-2.8	-3.5	2.6