[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr5:155,758,384-157,862,392

Best TWAS P=8.25e-116 · Best GWAS P=9.11e-97 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	ADAM19	0.09	0.08	lasso	6	0.05	5.6e-05	-20.71	-20.6	2.8e-94	0.99	0.00	0.99	FALSE
2	GTEx	Adrenal Gland	ADAM19	0.17	0.08	enet	1	0.06	3.6e-03	-5.20	-5.2	2.0e-07	0.31	0.20	0.72	TRUE
3	GTEx	Artery Tibial	ADAM19	0.09	0.00	enet	21	0.01	3.0e-02	-16.67	-14.6	3.6e-48	0.59	0.12	0.58	TRUE
4	GTEx	Brain Hypothalamus	MED7	0.30	0.02	enet	30	0.02	1.0e-01	-0.76	-6.1	1.2e-09	0.02	0.07	0.06	FALSE
5	GTEx	Breast Mammary Tissue	ADAM19	0.11	0.10	lasso	1	0.06	3.6e-04	-20.70	-20.7	3.3e-95	1.00	0.01	0.99	FALSE
6	GTEx	Breast Mammary Tissue (Male)	ADAM19	0.08	0.03	lasso	1	-0.01	7.7e-01	14.16	-14.2	1.7e-45	0.21	0.05	0.21	FALSE
7	GTEx	Breast Mammary Tissue (Female)	ADAM19	0.11	0.14	lasso	6	0.10	5.1e-04	-20.87	-20.5	6.0e-93	0.98	0.01	0.92	TRUE
8	GTEx	Cells Transformed fibroblasts	THG1L	0.21	0.08	enet	34	0.12	2.1e-09	2.36	-5.7	1.3e-08	0.30	0.94	0.01	FALSE
9	GTEx	Cells Transformed fibroblasts	ADAM19	0.16	0.02	enet	17	0.06	3.0e-05	12.33	-21.8	3.7e-105	0.63	0.05	0.94	FALSE
10	GTEx	Colon Sigmoid	CYFIP2	0.24	0.26	lasso	5	0.24	6.2e-09	-13.36	-13.5	1.0e-41	0.28	0.98	0.00	FALSE
11	GTEx	Esophagus Mucosa	ADAM19	0.14	0.03	enet	19	0.09	2.4e-06	8.22	-18.6	1.7e-77	0.57	0.06	0.90	FALSE
12	GTEx	Muscle Skeletal	ADAM19	0.06	0.02	lasso	4	0.01	1.5e-02	-20.87	-21.9	4.4e-106	0.88	0.01	0.99	FALSE
13	GTEx	Nerve Tibial	ADAM19	0.34	0.16	enet	45	0.30	1.2e-21	-15.24	-19.3	9.6e-83	0.78	0.01	0.99	FALSE
14	GTEx	Ovary	ADAM19	0.32	0.11	lasso	9	0.08	6.5e-03	-11.79	-18.3	5.4e-75	0.65	0.05	0.73	TRUE
15	GTEx	Skin Not Sun Exposed Suprapubic	ADAM19	0.10	0.01	lasso	4	0.08	5.2e-05	-15.72	-20.8	1.9e-96	0.75	0.02	0.98	FALSE
16	GTEx	Skin Sun Exposed Lower leg	ADAM19	0.07	0.04	lasso	6	0.06	1.2e-05	-14.86	-21.5	1.3e-102	0.80	0.02	0.98	TRUE
17	GTEx	Skin Sun Exposed Lower leg	MED7	0.07	0.01	enet	7	0.01	4.6e-02	14.33	10.8	2.3e-27	-0.12	0.23	0.08	FALSE
18	GTEx	Stomach	ADAM19	0.15	0.00	enet	5	0.03	1.1e-02	-8.71	-11.1	1.9e-28	0.42	0.18	0.53	FALSE
19	GTEx	Testis	ADAM19	0.16	0.00	enet	17	-0.01	6.7e-01	-15.16	-21.7	1.5e-104	0.82	0.02	0.90	FALSE
20	GTEx	Whole Blood	ADAM19	0.12	0.07	enet	20	0.07	9.8e-07	-15.52	-19.4	6.3e-84	0.57	0.89	0.11	FALSE
21	METSIM	Adipose	ADAM19	0.08	0.07	lasso	9	0.07	2.5e-10	-20.70	-20.7	3.1e-95	1.00	0.00	1.00	FALSE
22	NTR	Blood	HAVCR1	0.02	0.00	bslmm	479	0.01	3.9e-03	-0.63	10.4	1.9e-25	-0.14	0.06	0.03	TRUE
23	ROSMAP	Brain Pre-frontal Cortex	ADAM19	0.14	0.04	lasso	5	0.05	5.8e-07	-14.65	8.8	8.5e-19	-0.34	0.77	0.01	TRUE
24	ROSMAP	Brain Pre-frontal Cortex	FNDC9	0.09	0.02	bslmm	491	0.04	6.5e-06	-15.19	-14.1	5.0e-45	0.32	0.79	0.01	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	CYFIP2	0.03	0.02	blup	136	0.02	8.3e-06	-8.89	-14.4	4.7e-47	0.53	0.22	0.62	FALSE
26	The Cancer Genome Atlas	Colon Adenocarcinoma	NIPAL4	0.12	0.10	blup	71	0.11	1.1e-06	0.43	-8.4	3.2e-17	0.45	0.77	0.18	FALSE
27	The Cancer Genome Atlas	Glioblastoma Multiforme	NIPAL4	0.30	0.21	blup	69	0.23	1.7e-07	4.04	6.7	2.7e-11	0.09	0.53	0.04	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADAM19	0.08	0.02	blup	159	0.03	5.3e-04	-14.87	-22.9	8.2e-116	0.70	0.04	0.76	TRUE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	ADAM19	0.09	0.03	lasso	4	0.05	2.4e-06	-20.70	-22.8	1.2e-114	0.83	0.01	0.98	FALSE
30	The Cancer Genome Atlas	Prostate Adenocarcinoma	ADAM19	0.05	0.01	blup	159	0.03	9.5e-04	12.22	-22.5	4.9e-112	0.57	0.06	0.25	TRUE
31	The Cancer Genome Atlas	Soft Tissue Sarcoma	C5orf40	0.08	0.03	blup	79	0.05	6.7e-04	-15.20	-12.6	2.8e-36	0.56	0.01	0.97	FALSE
32	The Cancer Genome Atlas	Thyroid Carcinoma	ADAM19	0.07	0.00	blup	159	0.02	2.0e-03	8.21	-21.4	1.8e-101	0.49	0.15	0.18	FALSE
33	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	NIPAL4	0.20	0.08	lasso	2	0.14	1.3e-04	10.70	-11.5	9.4e-31	0.34	0.12	0.24	TRUE