Hub : Genes

MED7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hypothalamus	0.299	0.095	0.0018	0.016	NA	0.022	NA	-0.013	0.13000	NA	1.0e-01	NA	0.92000
2	GTEx	Skin Sun Exposed Lower leg	0.071	0.029	0.0024	0.006	NA	0.010	NA	0.008	0.09700	NA	4.6e-02	NA	0.06300
3	GTEx	Testis	0.152	0.063	0.0048	0.083	NA	0.097	NA	0.079	0.00015	NA	4.3e-05	NA	0.00022
4	TCGA	Pancreatic Adenocarcinoma	0.337	0.141	0.0020	0.011	0.039	0.050	NA	0.014	0.10000	0.0092	3.6e-03	NA	0.08000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.6	1.0	3.1	0.6	-0.7	0.5	-1.8
Bipolar Disorder or Schizophrenia	0.9	2.1	3.9	-1.3	-0.5	2.0	-1.7
Depressed Affect (Nagel 2018)	0.2	0.4	1.3	1.2	0.4	-0.3	-0.1
Depression (Nagel 2018)	0.3	0.5	1.8	0.3	0.0	-0.2	-1.3
Intelligence (Savage-Jansen 2018)	0.5	1.4	4.6	-2.1	-0.2	0.8	-0.5
Neuroticism (Nagel 2018)	0.2	0.5	1.8	1.3	0.1	0.0	0.0
Schizophrenia (2018)	1.2	2.5	5.0	-2.1	-0.2	2.2	-0.7
Schizophrenia vs Biploar Disorder	0.4	0.5	1.2	-0.4	0.4	1.1	0.6
Worry (Nagel 2018)	0.2	0.4	1.1	1.0	0.1	0.7	-0.3
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	-0.4	-0.5	-0.1	0.4
Alzheimer’s Disease (in father)	1.2	1.3	3.1	-1.1	1.8	0.8	0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	-0.9	0.6	0.4	0.0
Crohns Disease (2017)	0.1	0.3	0.8	0.9	0.4	0.2	-0.3
Irritable Bowel Disease (IBD)	0.1	0.3	0.5	-0.5	0.7	0.6	-0.1
Ulcerative Colitis (UC)	0.3	0.6	1.9	-1.4	0.4	0.7	-0.1
Major Depression (MDD)	1.1	1.3	3.7	-0.9	0.6	1.9	-0.6
Reaction Time	0.3	0.5	1.3	-1.2	-0.7	-0.3	0.5
Verbal and Numeric Reasoning (VNR)	0.7	1.7	6.7	-2.6	0.2	0.3	-0.1
Breast Cancer	0.0	0.1	0.1	-0.4	-0.2	-0.2	-0.0
Ovarian Cancer	0.4	0.5	1.0	0.8	0.5	0.3	1.0
Prostate Cancer	0.8	1.2	1.9	-1.4	1.3	0.9	0.6
Age at First Birth	0.6	0.8	1.8	-1.2	1.3	0.4	0.1
Bipolar Disorder (2011)	0.4	0.4	0.9	0.9	0.0	-0.0	-0.9
Body Mass Index (BMI) (2010)	0.4	0.6	1.1	0.9	-0.5	-1.1	0.0
Coronary Artery Disease (CAD)	0.5	0.6	1.6	-1.3	0.3	0.7	-0.5
Crohns Disease (2012)	0.1	0.1	0.3	0.4	0.1	0.1	0.5
Mean Putamen Volume	1.1	1.3	2.4	-1.4	0.7	0.4	-1.5
Fasting Glucose	1.0	1.2	4.1	-0.7	0.0	2.0	0.3
HbA1C	0.5	0.5	1.3	-1.2	-0.3	0.8	-0.2
HDL Cholesterol	0.4	0.7	1.3	1.0	-0.1	0.6	-1.1
LDL Cholesterol	0.2	0.4	0.7	-0.8	0.6	-0.6	-0.3
Lupus	0.4	0.6	1.7	-0.4	-0.8	1.3	-0.3
Neuroticism (2016)	0.7	1.1	2.8	1.7	1.1	0.3	0.5
Primary Biliary Cirrhosis	2.2	3.2	8.0	2.8	-0.7	-2.0	0.2
Rheumatoid Arthritis	0.8	1.1	2.1	0.3	-1.2	0.9	1.5
Schizophrenia (2014)	0.7	1.6	4.2	-0.6	-0.4	2.1	-1.2
Triglycerides	0.4	0.7	1.0	1.0	-0.9	-0.8	0.5
Type 2 Diabetes (T2D) (2012)	0.6	0.6	2.4	1.5	0.1	-0.3	0.3
Ulcerative Colitis	0.5	0.7	1.4	-1.2	-0.4	0.8	0.8
Blood Eosinophil Count	0.7	5.0	18.0	1.1	4.2	-0.8	0.5
Blood Platelet Count	0.4	4.3	12.9	1.8	3.6	-0.9	-0.4
Blood Red Count	0.3	3.1	6.8	1.4	-2.6	-1.7	-0.9
Blood White Count	0.9	6.5	8.4	2.8	-2.9	-2.9	1.4
Heel T-Score	0.2	1.7	2.7	-1.6	1.2	1.2	-1.0
BMI	0.2	1.1	2.2	0.0	1.5	1.0	-1.1
Height	0.1	2.8	6.5	2.5	-2.0	0.8	-0.1
Waist Hip Ratio (WHR)	0.1	0.3	0.5	0.7	-0.4	-0.6	-0.5
Systolic Blood Pressure	0.1	0.6	2.2	-0.2	-0.1	-1.5	0.5
Smoking Status	2.4	5.7	15.8	4.0	-0.8	-2.1	-1.4
Allergy or Eczema	0.2	0.6	1.9	0.0	1.4	-0.5	0.4
Cardiovascular Disease	0.8	2.6	7.1	0.3	-1.7	-2.7	0.4
Hypothyroidism (self reported)	5.0	11.6	23.4	3.5	0.8	-4.8	3.2
Respiratory disease	0.4	0.8	2.1	1.4	-1.0	0.1	0.4
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.4	0.5	-1.5	0.0	-0.3
Lung FEV1/FVC ratio	8.5	42.9	116.6	-6.1	10.8	4.2	-0.5
Lung FVC	0.4	2.0	5.7	-1.4	2.4	-0.2	0.3
Neuroticism	0.3	0.7	1.4	1.2	-0.8	0.6	-0.5
Chronotype (morning person)	0.8	1.8	5.5	-0.6	0.7	-0.9	2.3
Hair Pigment	0.0	0.8	1.3	1.1	-0.7	-0.2	-1.1
Tanning	0.1	0.7	1.5	-0.8	1.2	0.1	0.9
Hand grip strength (left)	0.6	1.5	3.2	0.5	-1.4	-0.8	-1.8
Number of treatments/medications taken	4.0	7.2	16.4	4.0	-0.8	-3.2	1.1
Average weekly spirits intake	1.5	1.8	3.7	1.3	-1.4	-0.5	-1.9
Sensitivity / hurt feelings	0.4	0.7	1.4	1.0	-0.3	-0.5	1.2
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.4	0.5	-0.1	0.2	-1.2
Hearing difficulty/problems: Yes	0.1	0.1	0.3	-0.2	-0.3	0.2	-0.5
Relative age of first facial hair	3.5	7.1	16.3	-3.3	4.0	1.1	-0.2
Other serious medical condition/disability diagnosed by doctor	4.0	5.2	11.3	3.4	0.0	-2.9	1.0
Ever used hormone-replacement therapy (HRT)	2.5	3.1	5.1	1.9	0.5	-2.3	1.9
Ever had hysterectomy (womb removed)	0.4	0.5	1.1	0.1	1.0	-0.9	0.1
Systolic blood pressure, automated reading	0.1	0.3	1.1	-0.0	1.0	-0.3	0.4
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.9	-0.5	0.4	1.4	-0.4
Angina	0.3	0.3	0.4	-0.6	-0.4	0.6	-0.7
Medication for hormone replacement therapy	1.3	1.5	2.1	0.9	1.0	-1.4	1.5
Vitamin and mineral supplements	1.0	1.4	2.7	-1.0	0.9	1.6	-1.1
Supplements: Zinc	0.4	0.4	0.8	0.8	0.2	-0.4	-0.9
Medication: Co-codamol	0.2	0.2	0.8	0.3	-0.0	-0.9	-0.1
Medication: Metformin	0.2	0.3	0.6	-0.6	0.8	0.5	0.2
Diabetes (father)	0.1	0.1	0.2	-0.1	0.4	0.3	-0.5
Diabetes (mother)	0.4	0.5	1.2	-0.8	0.4	0.0	1.1
Severe depression (siblings)	0.9	1.0	2.5	-0.1	-1.6	1.0	-0.6
Pack years adult smoking proportion	0.4	0.7	2.4	-0.2	-1.5	-0.1	-0.5
Impedance of leg (right)	0.1	0.4	0.9	0.6	-0.4	-0.9	-0.3
Leg fat-free mass (left)	0.1	0.5	2.1	-0.2	0.2	1.4	0.0
Trunk fat percentage	0.6	2.2	7.5	-0.5	2.7	0.8	-0.7
Hand grip strength (right)	1.3	3.7	12.3	0.5	-1.4	-0.4	-3.5
Townsend deprivation index at recruitment	1.9	2.6	5.7	1.8	-2.4	-0.6	-1.0
Current tobacco smoking	0.7	1.1	2.4	1.5	0.0	0.3	-1.4
Average weekly fortified wine intake	0.4	0.5	1.3	-0.1	-0.6	-1.2	0.4
Maternal smoking around birth	0.9	1.3	4.3	0.7	0.1	0.5	-2.1
Fed-up feelings	0.5	0.9	1.5	1.2	0.7	-0.2	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	2.8	1.5	-1.3	-1.7	-0.8
Relative age voice broke	2.6	3.9	12.7	-1.6	3.6	-0.6	0.1
Taking other prescription medications	2.8	4.3	9.5	3.1	-0.3	-1.5	2.3
Age when periods started (menarche)	1.4	3.3	11.9	-0.7	3.5	-0.5	0.8
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.4	1.5	0.4	-1.2	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.7	-0.4	0.1	1.6	0.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.1	-0.9	-0.1	-0.7	1.5
Qualifications: CSEs or equivalent	1.9	2.4	6.5	-0.8	-0.4	1.6	-2.6
Serious illness, injury or assault to yourself	1.3	1.6	2.9	1.6	-1.7	-1.0	-0.3
High blood pressure	0.4	1.1	3.9	0.6	-0.4	-2.0	-0.1
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.1	-0.2	0.7	-1.0	-0.0
Multivitamins +/- minerals	0.2	0.3	0.6	-0.5	-0.5	-0.3	0.8
Stomach or abdominal pain in last month	0.2	0.3	0.7	0.6	0.0	0.4	0.8
Supplements: Glucosamine	0.5	0.6	2.0	-1.4	0.6	-0.0	0.3
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.1	-0.2	1.4	1.1	-1.3
Medication: Atenolol	0.4	0.6	1.5	-1.2	-0.1	0.6	-0.6
Medication: Levothyroxine sodium	4.8	8.1	15.1	2.8	1.2	-3.9	2.9
Sitting height	0.4	3.0	5.5	1.2	-2.2	-0.1	2.4
Chronic bronchitis/emphysema (father)	0.4	0.5	1.2	-0.4	0.2	0.6	1.1
High blood pressure (mother)	1.0	1.4	2.9	0.5	-1.5	-1.7	0.5
Body mass index (BMI)	0.4	1.6	2.4	-0.6	1.6	1.2	-1.4
Impedance of leg (left)	0.1	0.5	1.4	0.7	-0.1	-1.2	0.1
Leg predicted mass (left)	0.1	0.5	2.1	-0.3	0.2	1.4	0.0
Trunk fat mass	0.5	2.1	5.8	-0.8	2.4	1.3	-0.4
Waist circumference	0.2	0.8	1.2	-0.2	1.1	1.1	-1.0
Number of incorrect matches in round	0.6	0.9	1.3	-0.5	1.2	1.1	-1.0
Past tobacco smoking	3.0	5.5	14.2	-3.8	0.8	2.7	0.5
Alcohol usually taken with meals	1.0	1.6	5.7	0.2	0.3	0.6	2.4
Nervous feelings	0.2	0.3	1.1	-0.0	0.3	1.0	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.5	1.0	-0.9	-0.7	-1.6
Hearing difficulty/problems with background noise	0.2	0.4	1.2	-1.1	-0.4	0.0	-0.4
Hair/balding pattern: Pattern 2	2.1	2.7	8.3	-2.9	1.1	0.8	-0.7
Had menopause	0.5	0.6	1.3	-0.1	1.0	0.3	-1.1
Had other major operations	0.5	0.7	2.4	0.1	-1.6	-0.5	-0.1
Forced vital capacity (FVC)	0.3	1.2	3.3	-0.7	1.8	0.3	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	0.0	-0.5	0.1	0.2
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	4.0	2.0	-0.0	-1.5	0.5
Qualifications: None of the above	0.2	0.5	1.2	1.1	0.2	0.2	0.9
Financial difficulties in last 2 years	0.9	1.2	3.1	1.8	-0.4	-1.1	-0.7
Mouth/teeth dental problems	0.6	1.0	2.6	-0.3	-0.1	-1.6	1.1
Heart attack	0.4	0.5	1.5	-1.2	-0.5	-0.0	-0.5
Allergy	0.3	0.7	1.3	-0.9	0.9	1.1	-0.1
Pain all over the body in last month	1.2	1.3	3.1	1.4	-0.3	-0.0	-1.8
Diabetes (self-reported)	0.3	0.5	1.1	1.0	-0.7	-0.3	0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	0.8	-0.2	-0.6	-0.4
Medication: Ramipril	0.1	0.1	0.3	0.4	-0.6	-0.2	-0.2
Medication: Simvastatin	0.9	1.3	3.0	0.3	-1.7	-1.5	-0.0
Fluid intelligence score	0.5	1.0	3.5	-1.9	0.5	-0.3	0.6
Illnesses of siblings	0.5	0.7	1.8	-0.3	-0.3	-0.9	1.3
Neuroticism score	0.4	0.8	1.9	1.4	-0.6	0.6	-0.8
Weight	0.2	1.1	2.9	-0.5	1.1	1.7	-0.5
Impedance of arm (right)	0.3	1.2	3.9	-0.5	2.0	-0.3	0.7
Arm fat percentage (right)	0.8	3.0	8.2	-1.3	2.9	1.3	-0.6
Trunk fat-free mass	0.1	0.8	1.9	-0.1	-1.0	1.4	0.3
Hip circumference	0.1	0.4	1.1	0.1	1.1	0.5	-0.1
Time employed in main current job	1.1	1.3	3.4	-0.2	1.8	1.3	0.3
Alcohol intake versus 10 years previously	0.4	0.5	1.5	0.7	0.3	-0.2	1.2
Father’s age at death	1.3	1.8	3.2	-1.2	-0.7	1.8	-1.4
Worrier / anxious feelings	0.3	0.6	1.1	0.3	-0.1	1.1	-1.0
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	6.5	1.4	-0.3	-1.3	-2.5
Falls in the last year	0.2	0.3	0.7	-0.8	-0.0	0.2	-0.6
Hair/balding pattern: Pattern 3	1.8	2.7	7.1	2.7	-0.8	-1.1	1.3
Number of live births	1.4	2.0	3.8	1.9	-1.8	-0.6	-0.7
Forced expiratory volume in 1-second (FEV1)	2.1	7.0	20.7	-2.3	4.5	1.3	0.7
Pulse rate	1.0	1.7	2.4	1.2	-1.5	-1.6	-0.9
Happiness	0.8	1.0	2.1	-1.5	0.7	1.1	-0.4
Noisy workplace	0.4	0.5	1.6	0.1	-0.4	0.4	-1.3
Qualifications: A levels/AS levels or equivalent	0.8	1.7	6.4	-2.5	-0.1	0.8	-0.0
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	1.9	0.6	-1.3	-0.6	-1.4
Mouth/teeth dental problems: Dentures	0.6	1.0	3.2	1.8	0.3	-0.7	-0.2
Asthma	1.9	3.7	8.3	2.2	-2.9	-1.2	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.5	0.9	-0.7	0.9	-1.2
Medication: Cholesterol lowering	0.4	0.7	1.7	-0.8	-1.3	-0.5	-0.3
Depression (self-reported)	1.2	1.4	2.3	1.4	-1.0	1.5	-0.7
Medication: Lansoprazole	1.1	1.3	4.5	2.1	0.2	-0.6	0.6
Prospective memory result	0.3	0.4	1.2	0.4	0.2	0.1	-1.1
Lung cancer (father)	1.7	2.0	4.0	-0.1	0.4	-1.9	2.0
Illnesses of mother	0.1	0.2	0.6	0.7	0.2	-0.0	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	7.0	19.2	-2.4	4.4	1.4	0.9
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	-0.5	-0.3	-0.3	-0.6
Impedance of arm (left)	0.2	0.8	2.5	-0.1	1.6	-0.7	0.4
Arm fat mass (right)	0.5	1.9	4.2	-1.0	2.0	1.5	-0.4
Trunk predicted mass	0.1	0.8	2.0	-0.0	-1.1	1.4	0.3
Standing height	0.1	1.3	3.5	0.3	-0.7	1.1	1.9
Length of working week for main job	1.8	2.0	6.1	-0.4	1.4	0.0	2.5
Exposure to tobacco smoke at home	1.0	1.1	2.0	-0.5	-1.4	0.7	-1.3
Breastfed as a baby	1.7	2.1	2.2	-1.4	1.4	1.5	-1.5
Tense / ‘highly strung’	1.1	1.8	3.6	0.6	-0.6	1.8	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.4	-0.0	-0.4	-0.2
Hair/balding pattern: Pattern 4	0.5	1.2	3.4	1.8	-1.1	-0.3	-0.5
Birth weight of first child	1.0	1.8	4.0	-1.0	-2.0	1.2	-0.9
Peak expiratory flow (PEF)	0.7	1.7	4.5	-1.2	2.1	0.9	-0.2
Pulse wave reflection index	2.0	2.5	4.2	-1.9	1.2	2.1	-0.9
Ever highly irritable/argumentative for 2 days	1.2	1.4	4.6	-0.2	-2.1	0.7	-0.6
Loud music exposure frequency	1.0	1.1	3.2	0.7	-1.8	-0.8	0.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	5.3	-2.3	0.3	0.6	-0.8
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.0	0.2	-0.1	-0.1	-0.2
Blood clot in the leg (DVT)	0.3	0.4	0.7	0.4	0.3	-0.8	-0.8
Medication: Paracetamol	1.9	3.2	8.1	2.0	-0.8	-0.1	-2.8
Headache pain in last month	1.6	2.8	5.9	1.2	-1.6	1.2	-2.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.8	-0.0	1.7	0.6	0.1
Glaucoma (self-reported)	0.2	0.2	0.5	0.4	0.0	0.3	-0.7
Gout (self-reported)	0.4	0.6	1.4	0.2	-1.2	-0.8	-0.6
Hypothyroidism/myxoedema (self-reported)	5.3	10.4	18.5	3.0	1.6	-4.3	3.4
Medication: Amlodipine	1.5	2.0	5.1	1.5	-0.9	-2.3	0.2
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.0	0.8	-1.4	0.0	0.5
Birth weight	0.0	0.1	0.3	-0.2	-0.2	0.5	0.2
Chronic bronchitis/emphysema (mother)	1.5	1.7	4.2	-1.6	-0.4	2.1	-0.2
High blood pressure (siblings)	0.1	0.2	0.3	0.5	0.0	-0.5	-0.5
Forced vital capacity (FVC), Best measure	0.5	1.7	3.0	-1.1	1.7	0.9	1.4
Body fat percentage	0.5	1.8	5.3	-0.6	2.3	0.9	-0.9
Leg fat percentage (right)	0.6	2.1	3.9	-0.9	2.0	1.5	-1.3
Arm fat-free mass (right)	0.1	0.5	1.3	0.0	-0.7	1.1	-0.2
Exposure to tobacco smoke outside home	0.4	0.6	1.4	-1.2	-0.9	0.1	-0.2
Comparative body size at age 10	2.6	7.2	19.3	-4.4	2.7	1.5	0.2
Number of full brothers	1.4	1.8	6.3	2.5	-0.7	-0.6	-0.1
Worry too long after embarrassment	1.2	1.9	3.9	1.4	-2.0	-0.3	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.8	0.5	-1.3	0.2	-1.1
Wheeze or whistling in the chest in last year	0.8	1.5	3.5	1.5	-1.9	0.1	-0.4
Number of children fathered	1.4	1.6	4.1	0.9	2.0	-0.4	1.2
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.4	4.6	1.8	-2.1	-1.3	0.1
Age at first live birth	1.7	3.1	10.1	-3.2	-1.2	0.8	0.3
Pulse wave peak to peak time	0.3	0.3	0.7	0.7	0.3	0.3	0.8
Health satisfaction	0.4	0.5	1.3	0.7	0.4	-1.1	-0.4
Shortness of breath walking on level ground	0.1	0.2	0.5	0.2	-0.7	0.3	0.1
Qualifications: College or University degree	0.3	0.8	1.9	-1.4	-0.1	-0.8	0.9
Eye problems/disorders: None of the above	0.6	0.7	1.4	-0.3	-0.2	-1.2	1.1
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.8	-1.3	0.8	0.6	-0.2
Emphysema/chronic bronchitis	1.0	1.1	3.1	-0.7	0.6	1.7	-0.9
Medication for pain relief, constipation, heartburn	2.4	4.0	7.3	-2.7	1.8	0.8	2.2
Neck or shoulder pain in last month	0.9	1.3	2.8	1.7	0.5	-1.0	-1.1
Medication: Blood pressure	0.7	1.2	2.4	0.4	-1.6	-1.3	-0.7
Angina (self-reported)	0.3	0.4	0.6	-0.8	-0.2	0.7	-0.7
Migraine (self-reported)	2.2	2.8	5.2	1.5	-2.3	0.3	-1.9
Medication: Ibuprofen	0.4	0.5	0.9	0.4	0.1	0.9	-0.9
Medication: Allopurinol	0.3	0.4	0.9	-0.7	-0.4	0.1	-0.9
Medication: Omeprazole	1.3	1.6	4.2	1.2	0.4	-2.1	0.7
Medication: Seretide 50 evohaler	1.3	1.5	3.3	0.6	-1.2	-0.9	1.8
Mean time to correctly identify matches	0.6	1.2	3.5	-1.9	-0.7	0.5	0.6
Heart disease (mother)	0.6	0.7	1.1	-0.5	-1.0	-0.9	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.7	0.9	0.3	-0.0	-1.3
Whole body fat mass	0.4	1.8	4.0	-0.8	2.0	1.4	-0.8
Leg fat mass (right)	0.5	1.7	2.6	-0.9	1.6	1.6	-1.1
Arm predicted mass (right)	0.1	0.6	1.3	-0.1	-1.0	1.1	-0.5
Pulse rate, automated reading	0.8	2.5	5.1	2.3	0.2	-2.2	0.3
Alcohol intake frequency.	0.6	1.4	3.4	-1.3	-0.1	1.8	0.8
Comparative height size at age 10	1.0	5.4	18.7	1.6	-4.3	0.5	0.2
Number of full sisters	0.2	0.3	0.7	0.5	-0.9	-0.1	-0.2
Suffer from ‘nerves’	0.2	0.3	0.5	0.3	0.7	-0.5	0.6
Overall health rating	1.9	4.0	11.1	1.9	-0.9	-0.6	-3.3
Chest pain or discomfort	1.0	1.4	2.7	0.9	-1.6	1.3	-0.7
Had major operations	0.6	0.7	1.8	1.3	-0.6	-0.8	0.5
Age at last live birth	0.7	1.0	2.5	-1.6	-0.9	-0.0	0.8
Family relationship satisfaction	0.5	0.6	1.7	-0.8	1.3	0.3	0.1
Leg pain on walking	0.8	1.0	2.2	-0.6	-1.5	0.6	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.6	-0.1	-0.4	0.3	-1.3
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.1	-0.1	1.0	0.5	1.0
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.3	-0.7	0.3	0.6	1.1
Medication: Aspirin	0.9	1.2	2.0	1.1	-0.9	-1.4	-0.8
Supplements: Vitamin C	0.6	0.7	1.6	0.4	0.5	-1.3	0.8
Knee pain experienced in last month	0.3	0.5	1.0	1.0	-0.5	0.3	-0.8
Hypertension (Self-reported)	0.5	1.3	4.3	0.6	-0.8	-2.1	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.1	0.3	0.5	0.1	1.1
Illnesses of father: Heart disease	0.9	1.3	1.9	1.1	-0.1	-1.4	1.4
Illnesses of siblings: Diabetes	0.5	0.6	1.3	1.1	-0.4	-0.9	0.3
Smoking status: Previous	2.8	4.1	10.3	3.2	-1.0	-2.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.4	-0.7	0.8	1.8	0.5
Whole body fat-free mass	0.1	0.5	1.7	-0.1	-0.6	1.3	0.2
Leg fat-free mass (right)	0.1	0.4	1.4	-0.2	0.1	1.2	0.4
Arm fat percentage (left)	0.8	3.1	8.4	-1.2	2.9	1.2	-1.0
Average weekly red wine intake	0.6	0.8	2.1	1.5	0.6	-0.8	0.5
Handedness (chirality/laterality): Left-handed	1.2	1.4	3.2	-1.3	-0.8	1.8	-0.4
Mood swings	0.1	0.2	0.5	0.7	0.7	0.3	0.0
Loneliness, isolation	0.8	1.1	2.7	1.2	1.6	0.4	-0.1
Long-standing illness, disability or infirmity	1.8	2.8	6.4	2.5	-1.3	-1.6	0.7
Ever had bowel cancer screening	0.7	0.9	1.9	-1.0	0.1	1.4	0.7
Diabetes diagnosed by doctor	0.5	0.8	2.2	1.5	-0.9	-0.6	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.6	1.5	-1.9	-0.1	-0.6
Friendships satisfaction	0.4	0.5	1.2	0.3	-1.1	-0.8	-0.5
Qualifications: nursing, teaching	0.6	0.9	1.9	-1.4	0.0	-0.2	1.3
Commuting to job workplace: Walk	0.3	0.3	0.6	0.0	0.7	-0.8	-0.4
Eye problems/disorders: Cataract	0.5	0.5	1.0	0.7	0.7	-1.0	0.4
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.8	-1.1	-0.1	1.7	-1.2
Medication for cholesterol	1.3	2.0	3.0	0.4	-1.7	1.6	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	4.0	-0.2	-2.0	-1.7	-1.1
Back pain experienced in last month	1.1	1.6	4.3	1.0	-2.1	-0.8	-0.6
Mineral and other dietary supplements	0.9	1.2	3.1	-0.7	-0.1	1.8	-1.0
Breast cancer (self-reported)	0.3	0.3	1.0	-0.4	-0.5	1.0	0.2
Asthma (self-reported)	1.7	3.3	6.5	2.2	-2.5	-1.3	0.6
Osteoporosis (self-reported)	1.0	1.2	2.9	-1.7	-0.0	0.3	1.3
Osteoarthritis (self-reported)	0.4	0.5	1.3	0.3	0.6	1.1	0.6
Medication: Aspirin	1.0	1.3	1.8	1.3	-1.1	-1.4	-0.5
Medication: Gliclazide	2.0	2.3	4.1	-1.7	-0.6	2.0	1.3
Illnesses of father: None of the above (group 1)	0.5	0.7	1.4	0.1	-1.0	0.6	-1.2
Smoking status: Current	0.6	1.0	2.2	1.5	0.3	0.3	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.8	8.0	19.8	-3.0	4.5	1.7	0.5
Whole body water mass	0.1	0.6	2.0	-0.1	-0.6	1.4	0.3
Leg predicted mass (right)	0.1	0.5	1.8	-0.3	0.3	1.4	0.4
Arm fat mass (left)	0.5	1.9	4.1	-0.9	2.0	1.4	-0.8
Number of self-reported non-cancer illnesses	3.0	5.2	9.2	3.0	-2.3	-2.4	0.8
Average weekly champagne plus white wine intake	0.7	1.0	3.4	0.3	-1.8	-0.1	0.7
Miserableness	0.2	0.3	1.2	0.3	-0.0	0.0	-1.1
Guilty feelings	0.3	0.5	1.8	0.2	0.0	0.4	-1.4
Wears glasses or contact lenses	0.7	0.8	1.8	-0.1	1.3	-0.8	0.7
Ever taken oral contraceptive pill	1.1	1.2	2.6	-1.3	0.8	1.6	0.0
Hearing aid user	0.1	0.1	0.2	0.1	0.3	-0.4	-0.3
Mother’s age at death	1.2	1.4	2.6	1.0	1.4	-0.4	-1.6
Financial situation satisfaction	0.2	0.2	0.4	-0.5	-0.6	0.1	-0.4
Tinnitus: Yes, now most or all of the time	2.0	2.3	8.4	0.7	-0.3	-0.4	-2.9
Commuting to job workplace: Public transport	0.6	0.7	2.1	0.0	-0.7	0.5	-1.4
Eye problems/disorders: Glaucoma	0.8	1.0	1.7	-0.8	0.7	1.1	-1.3
Medication: Blood pressure	0.6	1.2	2.3	0.2	1.0	-1.5	1.2
Pain type(s) experienced in last month: Hip pain	1.3	1.6	3.8	0.6	-1.9	-0.1	-1.5
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.8	0.7	-0.5	-0.9	0.3
High cholesterol (Self-reported)	0.7	1.3	2.1	-1.3	-1.4	-0.8	-0.8
Medication: Bendroflumethiazide	0.6	0.9	1.8	-0.0	-1.3	-1.3	0.2
Medication: Paracetamol	1.8	2.8	5.4	2.3	0.0	-0.6	-2.3
Medication: Lisinopril	1.3	1.6	5.5	0.5	-0.8	-2.4	0.1
Medication: Atorvastatin	0.2	0.2	0.6	-0.3	0.8	-0.3	-0.1
Illnesses of father: High blood pressure	1.3	1.6	4.1	1.4	-0.0	-2.0	0.3
Alcohol drinker status: Never	0.2	0.2	0.6	0.2	0.8	-0.5	0.4
Ever smoked	2.9	5.1	11.0	3.3	-1.2	-2.6	-1.2
Basal metabolic rate	0.1	0.4	1.7	-0.0	-0.3	1.3	0.1
Leg fat percentage (left)	0.6	2.0	4.3	-0.7	2.1	1.2	-1.2
Arm fat-free mass (left)	0.1	0.7	1.6	0.2	-1.0	1.3	0.1
Number of operations (self-reported)	0.2	0.3	0.7	0.3	-0.8	0.4	0.3
Average weekly beer plus cider intake	0.8	1.2	2.5	1.2	-0.1	-0.8	-1.6
Irritability	0.5	0.8	1.6	1.3	-0.4	-1.1	0.4
Risk taking	0.3	0.4	0.7	0.8	-0.8	-0.6	0.0
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.6	-0.8	-0.4	0.6	0.4
Fractured/broken bones in last 5 years	0.2	0.2	0.4	-0.6	-0.5	-0.1	0.6
Age started oral contraceptive pill	1.2	1.5	3.0	-1.2	1.0	1.7	0.9
Diastolic blood pressure, automated reading	0.0	0.1	0.3	0.1	0.2	-0.6	0.2
Ever depressed for a whole week	0.3	0.4	1.1	0.7	0.0	-0.4	1.0
Unable to work because of sickness or disability	2.1	2.7	4.0	1.7	-2.0	-1.4	-1.5
Commuting to job workplace: Cycle	0.5	0.6	1.2	-0.2	0.2	1.0	-1.1
Myopia	1.0	1.4	3.3	-1.4	0.6	1.8	0.1
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.9	-0.4	0.9	1.7	0.5
Cholesterol lowering medication	0.9	1.3	4.0	-0.4	0.6	-2.0	0.9
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.4	1.1	0.3	-1.8	0.3
Pain experienced in last month	0.9	1.6	2.5	-1.6	1.4	-0.3	1.3
Supplements: Calcium	1.0	1.1	2.5	-1.6	0.9	0.3	1.0
Basal cell carcinoma (self-reported)	1.4	1.7	3.2	0.3	-0.7	1.8	-1.7
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.7	-1.3	-0.5	0.2	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.7	0.4	0.3	-0.6	-0.8
Heart disease (siblings)	1.7	2.1	6.1	-1.3	-0.4	2.5	-0.7
Alcohol drinker status: Previous	0.4	0.5	1.4	-0.7	-1.2	0.1	-0.1
Pack years of smoking	0.4	0.6	2.2	-0.4	-1.5	-0.2	-0.2
Impedance of whole body	0.1	0.6	1.5	0.4	0.8	-1.2	0.3
Leg fat mass (left)	0.4	1.6	2.7	-0.8	1.6	1.4	-0.9
Arm predicted mass (left)	0.1	0.5	1.1	0.3	-0.8	1.1	-0.1