TWAS hub - HAVCR1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0930	0.0270	2.6e-07	0.082	0.064	0.096	0.073	0.081	3.7e-10	2.8e-08	8.8e-12	3.5e-09	4.1e-10
2	NTR	Blood	0.0179	0.0110	3.3e-02	0.004	0.004	0.002	0.006	0.004	2.0e-02	1.6e-02	7.1e-02	3.9e-03	1.7e-02
3	TCGA	Colon Adenocarcinoma	0.1960	0.0750	3.1e-06	0.132	0.098	0.105	NA	0.107	5.0e-08	2.6e-06	1.2e-06	NA	9.0e-07
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.1751	0.0478	0.0e+00	0.215	0.201	0.231	NA	0.236	9.8e-24	3.6e-22	1.2e-25	NA	3.5e-26
5	TCGA	Brain Lower Grade Glioma	0.0687	0.0374	3.7e-05	0.066	0.037	0.052	NA	0.062	5.2e-08	4.0e-05	1.5e-06	NA	1.3e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
High cholesterol (Self-reported)	7.9	13.9	28.2	4.5	3.0	-5.3	-0.0	3.5
LDL Cholesterol	7.0	11.1	24.7	4.2	2.1	-5.0	-1.3	2.7
Lung FEV1/FVC ratio	5.3	27.0	108.2	1.7	10.4	3.5	3.4	0.9
Handedness (chirality/laterality): Left-handed	4.0	4.8	14.7	3.0	-0.5	-0.1	-0.5	3.8
Medication: Omeprazole	3.8	4.5	12.4	-3.5	-0.2	-1.3	0.8	-2.7
Medication: Cholesterol lowering	3.7	5.7	15.3	1.8	2.6	-3.9	0.2	1.8
Other serious medical condition/disability diagnosed by doctor	3.1	4.0	11.0	-3.3	0.0	-0.4	0.1	-3.0
Knee pain experienced in last month	2.9	4.5	12.1	-1.4	1.1	1.5	3.5	-2.3
Triglycerides	2.8	4.6	14.8	2.6	1.0	-3.8	-0.4	0.7
Medication: Levothyroxine sodium	2.6	4.4	11.1	-2.9	1.1	-1.0	0.5	-3.3
Medication: Omeprazole (e.g. Zanprol)	2.5	3.1	8.6	-2.9	-0.4	-1.4	0.7	-2.1
Neck or shoulder pain in last month	2.3	3.3	4.6	-2.1	0.9	2.0	1.8	-2.0
Medication: Gliclazide	2.3	2.7	9.2	-1.5	-3.0	1.2	0.4	-0.5
Medication: Simvastatin	2.2	3.3	8.1	1.9	1.1	-2.8	-0.1	1.8
Pulse wave peak to peak time	2.2	2.6	5.3	-2.3	0.4	0.5	1.8	-2.0
Heart disease (siblings)	2.2	2.7	6.3	2.5	-0.2	0.6	1.0	2.4
Pulse wave Arterial Stiffness index	2.1	2.5	5.4	2.3	-0.5	-0.2	-1.8	1.9
Asthma	2.0	3.9	8.7	-0.1	-2.9	-1.4	-2.8	0.8
Medication: Lansoprazole	2.0	2.3	4.5	-1.9	-2.1	-0.6	-0.3	-1.7
Crohns Disease (2012)	1.9	3.1	7.2	-1.8	-0.7	2.7	1.3	-1.6
Loud music exposure frequency	1.9	2.1	3.6	-1.5	-1.6	-1.3	-1.9	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.4	7.5	0.8	-2.7	1.4	-0.7	1.3
Family relationship satisfaction	1.9	2.4	6.0	-1.3	-0.8	-1.2	-1.4	-2.5
Wears glasses or contact lenses	1.9	2.2	7.3	-0.3	-1.6	-1.0	-2.7	-0.1
Relative age of first facial hair	1.8	3.6	8.0	0.5	2.3	2.0	2.8	0.6
Severe depression (siblings)	1.8	2.0	3.6	1.6	0.9	0.1	1.9	1.7
Ovarian Cancer	1.7	2.3	4.5	-2.1	-1.5	0.8	-0.1	-2.0
Lupus	1.7	2.6	10.1	-0.1	0.4	1.6	3.2	-0.6
Smoking Status	1.7	4.1	10.8	-0.8	3.3	-2.6	-0.4	-1.4
Medication: Atenolol	1.7	2.1	6.0	1.4	0.7	1.1	2.4	0.9
Past tobacco smoking	1.7	3.2	5.4	1.7	-0.8	2.1	1.5	2.3
Medication: Ventolin 100micrograms inhaler	1.7	2.2	5.9	0.6	-1.9	-0.9	-2.4	0.6
Age at first live birth	1.7	3.1	4.8	1.5	-1.7	1.6	-1.7	2.2
Eye problems/disorders: Glaucoma	1.7	2.0	5.2	1.6	-0.8	1.0	-0.8	2.3
Type 2 Diabetes (T2D) (2012)	1.6	1.8	3.3	-1.3	1.8	0.6	1.8	-0.7
Hypothyroidism (self reported)	1.6	3.7	10.5	-2.5	0.8	-0.9	0.3	-3.2
Frequency of depressed mood in last 2 weeks	1.6	2.2	4.5	1.8	0.8	1.2	1.0	2.1
Ever used hormone-replacement therapy (HRT)	1.6	2.1	5.9	-1.7	-1.1	-0.6	-0.2	-2.4
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	6.9	-0.1	-1.0	-1.1	-2.6	0.0
Serious illness, injury or assault to yourself	1.6	1.9	3.0	-1.0	1.6	0.6	1.7	-1.6
Hypothyroidism/myxoedema (self-reported)	1.6	3.2	9.5	-2.1	1.2	-0.2	0.8	-3.1
Breast cancer (self-reported)	1.6	1.9	5.1	2.2	0.4	-0.0	1.8	1.1
Asthma (self-reported)	1.6	3.1	7.0	0.1	-2.6	-1.3	-2.5	0.7
Chronotype (morning person)	1.5	3.5	10.1	-1.8	0.5	1.5	3.2	-1.2
Number of treatments/medications taken	1.5	2.7	6.0	-2.3	-1.0	-1.1	0.3	-2.4
Depression (self-reported)	1.5	1.8	4.9	1.5	-0.7	-0.5	2.2	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	2.9	1.0	0.2	-1.7	-1.7	1.4
Smoking status: Previous	1.5	2.3	3.8	-1.4	0.7	-1.9	-1.2	-2.0
Ever had bowel cancer screening	1.5	1.8	3.9	1.5	-1.0	1.3	0.4	2.0
Ever smoked	1.5	2.6	4.5	-1.4	0.9	-1.9	-1.5	-2.1
Average weekly beer plus cider intake	1.5	2.1	3.5	-1.9	-1.2	-1.0	-1.2	-1.8
Allergy	1.4	3.1	5.9	1.3	1.9	1.5	2.4	1.3
Exposure to tobacco smoke outside home	1.4	1.9	3.7	1.9	-0.5	-1.1	-1.0	1.8
Pulse rate, automated reading	1.4	4.4	9.6	-3.1	1.0	-1.9	-0.2	-2.9
Commuting to job workplace: Car/motor vehicle	1.4	1.5	3.4	-1.1	-1.9	1.8	0.1	-0.3
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	5.0	-1.1	-2.2	1.4	0.8	0.2
Ever taken oral contraceptive pill	1.4	1.6	3.1	1.3	0.6	-1.5	-0.4	1.8
Crohns Disease (2017)	1.3	2.9	9.5	-1.3	-1.3	3.1	0.5	-1.1
Fasting Glucose	1.3	1.6	3.8	0.2	-2.0	-0.1	-1.4	1.4
Primary Biliary Cirrhosis	1.3	1.9	4.5	-0.8	0.7	-2.1	-0.0	-1.9
Blood Platelet Count	1.3	15.2	30.1	-5.5	0.0	4.1	2.1	-5.0
Cardiovascular Disease	1.3	4.3	10.5	1.8	3.2	-2.4	0.9	1.1
Respiratory disease	1.3	2.9	9.7	0.2	-3.1	-0.5	-1.8	1.1
Hair/balding pattern: Pattern 3	1.3	2.0	4.4	-2.1	-1.6	0.7	-0.8	-1.3
Noisy workplace	1.3	1.6	3.6	1.9	-0.1	0.9	-0.3	1.8
Pulse wave reflection index	1.3	1.6	3.4	1.6	-0.7	0.6	-1.2	1.8
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	6.4	-0.7	2.5	-1.2	-0.0	-0.1
Health satisfaction	1.3	1.7	5.5	-0.1	0.4	-2.4	-1.6	-0.3
Shortness of breath walking on level ground	1.3	1.5	3.9	0.0	-1.1	-2.0	-1.5	-0.1
Mean time to correctly identify matches	1.3	2.4	4.0	2.0	-2.0	1.5	-0.4	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	3.7	1.8	1.9	1.4	1.6	1.6
Financial situation satisfaction	1.3	1.6	5.1	-0.2	-1.5	-0.3	-2.3	-0.6
Ever had prostate specific antigen (PSA) test	1.3	1.5	4.1	1.3	-0.9	2.0	0.6	0.9
Schizophrenia vs Biploar Disorder	1.2	1.6	3.0	-1.1	-0.2	1.6	1.7	-1.0
Coronary Artery Disease (CAD)	1.2	1.4	3.2	1.3	-0.3	0.3	-1.8	1.4
Mean Putamen Volume	1.2	1.3	2.8	1.5	0.5	1.2	0.2	1.7
Chronic bronchitis/emphysema (father)	1.2	1.4	5.9	1.1	-0.0	0.2	2.4	0.1
Medication: Amlodipine	1.2	1.8	4.8	-0.8	2.2	-0.2	1.5	-1.0
Long-standing illness, disability or infirmity	1.2	1.9	4.1	-2.0	0.5	-1.4	0.3	-1.7
Illnesses of father: High blood pressure	1.2	1.5	3.3	-1.7	0.7	-0.9	-0.3	-1.8
Bipolar Disorder (2018)	1.1	1.7	7.3	0.2	1.0	-2.7	-0.3	0.5
Bipolar Disorder (2011)	1.1	1.0	2.3	1.5	0.6	-0.6	-1.0	1.0
Qualifications: None of the above	1.1	2.3	7.6	0.1	-0.8	1.7	2.8	-0.6
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	5.4	0.7	0.2	-1.6	-2.3	-0.0
Forced expiratory volume in 1-second (FEV1)	1.1	3.8	15.3	0.5	3.9	0.6	1.5	1.0
Pulse rate	1.1	1.8	4.0	-1.1	1.0	-2.0	-0.5	-1.6
Prospective memory result	1.1	1.3	4.8	0.4	2.2	-0.8	0.9	0.3
Birth weight of first child	1.1	2.0	3.3	1.5	-1.8	0.4	-1.1	1.8
Ever highly irritable/argumentative for 2 days	1.1	1.4	3.6	-1.0	-1.9	-1.2	-0.2	-0.8
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.2	1.0	-0.6	-0.9	-1.4	1.5
Eye problems/disorders: None of the above	1.1	1.2	3.3	0.5	1.4	-1.8	-0.5	0.5
Medication: Lisinopril	1.1	1.4	3.8	-0.8	1.2	0.8	2.0	-0.8
Ever depressed for a whole week	1.1	1.3	3.1	-1.7	-1.1	-0.6	-0.1	-1.4
Alcohol drinker status: Previous	1.1	1.3	2.3	1.1	-1.1	0.4	-1.2	1.5
Depression (Nagel 2018)	1.0	1.5	3.8	1.4	1.2	0.0	0.3	2.0
Alzheimer’s Disease (including proxy)	1.0	1.4	3.4	1.8	0.4	0.3	-0.4	1.8
Rheumatoid Arthritis	1.0	1.4	3.0	-1.7	-1.2	0.2	-0.1	-1.6
Hearing difficulty/problems: Yes	1.0	1.6	4.0	-0.3	0.4	2.0	1.6	-1.1
Average weekly fortified wine intake	1.0	1.2	3.4	0.6	-1.8	0.7	-1.3	0.3
Heart attack	1.0	1.3	4.9	0.2	0.8	-2.2	-0.7	0.6
Peak expiratory flow (PEF)	1.0	2.3	6.8	-0.0	2.6	1.2	1.8	0.2
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	4.1	-0.8	-1.4	2.0	-1.1	-0.7
Number of children fathered	1.0	1.1	4.0	-2.0	0.1	0.4	-0.8	-0.9
Emphysema/chronic bronchitis	1.0	1.2	2.9	1.5	0.5	0.0	0.6	1.7
Medication for pain relief, constipation, heartburn	1.0	1.7	3.6	1.9	-0.0	1.6	-0.1	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.0	-1.7	-1.0	-0.2	0.8	-1.2
Friendships satisfaction	1.0	1.3	4.0	-1.0	-0.9	-0.1	-0.7	-2.0
Medication: Atorvastatin	1.0	1.3	2.2	1.2	1.3	-1.5	0.9	0.5
Cholesterol lowering medication	1.0	1.4	3.3	1.8	0.4	-1.5	0.5	1.0
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.0	-0.7	0.6	-1.5	0.6	-1.7
Alzheimer’s Disease (in father)	0.9	0.9	2.3	1.2	-0.0	-0.9	-1.5	0.3
Irritable Bowel Disease (IBD)	0.9	2.2	6.9	-1.0	-1.4	2.6	0.6	-0.9
HbA1C	0.9	1.0	4.1	0.3	0.7	-2.0	0.4	0.6
Blood White Count	0.9	6.6	20.3	-3.2	-1.2	-0.9	0.4	-4.5
Ever had hysterectomy (womb removed)	0.9	1.0	4.5	-0.0	-0.8	-0.1	-2.1	0.2
Relative age voice broke	0.9	1.3	1.8	-1.0	1.0	1.3	1.2	-1.2
Multivitamins +/- minerals	0.9	1.2	3.0	1.7	-0.2	0.4	1.1	1.3
Alcohol usually taken with meals	0.9	1.4	2.1	1.2	-1.1	0.5	-1.4	1.5
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.2	-1.8	-0.0	-0.6	-0.2	-1.4
Time employed in main current job	0.9	1.0	2.0	-1.3	0.4	0.4	1.0	-1.4
Number of live births	0.9	1.2	1.7	-1.2	-1.1	-1.3	-0.4	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	8.2	0.0	2.9	1.9	1.5	0.5
Length of working week for main job	0.9	1.0	2.4	-0.3	-1.1	1.6	1.1	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	5.7	-0.6	-2.4	0.1	-0.9	-0.3
Blood clot in the leg (DVT)	0.9	1.2	3.0	-0.7	0.5	-1.4	0.4	-1.7
Age at last live birth	0.9	1.3	3.4	0.8	-1.0	-0.3	-1.8	1.1
Illnesses of father: Heart disease	0.9	1.3	3.9	0.7	1.2	-0.7	2.0	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	3.7	0.1	-0.0	-1.9	-1.2	-0.2
Medication: Paracetamol	0.9	1.4	3.4	-1.2	0.6	-0.5	1.9	-1.3
Heart attack/myocardial infarction (self-reported)	0.9	1.1	4.3	0.1	0.8	-2.1	-0.6	0.6
Ulcerative Colitis	0.8	1.1	2.1	-1.2	-1.4	0.9	1.1	-0.6
Blood Red Count	0.8	7.6	14.1	3.8	2.2	-3.5	-0.5	2.5
Vitamin and mineral supplements	0.8	1.1	3.4	-1.9	0.7	-0.0	-0.2	-1.2
Trunk fat percentage	0.8	3.4	6.0	-2.4	2.1	-0.6	1.2	-2.2
Qualifications: CSEs or equivalent	0.8	1.0	3.0	0.6	1.7	-0.0	-1.0	0.8
Illnesses of siblings	0.8	1.1	2.5	-1.6	0.7	0.2	0.3	-1.5
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.1	-0.6	0.6	-1.4	-0.8	-1.2
Lung cancer (father)	0.8	1.0	2.3	-0.5	-1.1	1.5	0.5	-0.9
Headache pain in last month	0.8	1.3	4.6	0.2	2.2	-0.8	1.1	0.4
Wheeze or whistling in the chest in last year	0.8	1.4	1.6	1.0	-1.2	-1.2	-1.3	1.2
Medication: Seretide 50 evohaler	0.8	1.0	2.8	-0.3	-1.7	-0.7	-1.2	-0.1
Overall health rating	0.8	1.6	5.4	-1.0	1.2	-2.3	-0.2	-0.5
Illnesses of siblings: Diabetes	0.8	1.0	3.4	0.4	-0.7	-1.0	-1.8	0.1
Arm fat percentage (left)	0.8	3.0	4.8	-2.2	2.0	-1.5	0.2	-2.0
Eye problems/disorders: Cataract	0.8	0.9	2.2	-1.4	0.3	0.4	0.4	-1.5
Medication for cholesterol	0.8	1.2	3.0	-1.2	-1.7	0.6	-0.4	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.5	0.6	-1.1	1.0	-1.2	0.6
Age started oral contraceptive pill	0.8	1.0	2.2	1.5	-1.0	0.9	0.0	0.9
Current tobacco smoking	0.7	1.2	2.8	-0.8	1.7	-0.4	1.1	-1.1
Age when periods started (menarche)	0.7	1.7	3.2	-1.6	1.8	-0.7	1.2	-0.9
Hayfever, allergic rhinitis or eczema	0.7	1.5	2.7	-1.2	-0.7	-0.8	-1.6	-1.5
Mouth/teeth dental problems: Dentures	0.7	1.3	2.9	-1.7	-0.8	-0.4	0.5	-1.5
Breastfed as a baby	0.7	0.9	2.5	1.3	0.0	-0.4	-0.2	1.6
Glaucoma (self-reported)	0.7	0.8	1.5	0.9	-1.2	0.6	-0.6	0.9
Number of full brothers	0.7	0.9	2.0	-1.4	-1.0	-0.2	0.4	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	1.9	1.2	-0.9	-0.0	-1.4	1.0
Back pain experienced in last month	0.7	1.0	1.8	1.2	1.3	-0.9	0.2	0.8
Smoking status: Current	0.7	1.1	3.2	-0.6	1.8	-0.4	1.0	-0.9
Number of self-reported non-cancer illnesses	0.7	1.3	4.4	-0.6	0.7	-2.1	0.5	-0.9
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.8	1.1	-0.2	1.3	1.0	0.3
Fractured/broken bones in last 5 years	0.7	0.8	1.4	-1.0	-1.2	0.1	-0.9	-1.0
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.3	1.5	1.0	-1.1	-0.3	1.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.4	-1.2	-1.0	0.9	0.3	-0.6
Angina	0.6	0.8	1.6	1.2	0.5	-1.3	-0.8	0.5
Townsend deprivation index at recruitment	0.6	0.9	3.2	0.8	0.7	-0.2	1.8	0.2
Taking other prescription medications	0.6	0.9	2.4	-0.8	-1.6	-0.9	0.7	-0.3
High blood pressure (mother)	0.6	0.8	2.4	0.1	1.6	-1.3	0.3	0.2
Pain all over the body in last month	0.6	0.6	1.2	-1.1	-1.0	0.2	0.5	-0.7
Medication: Ramipril	0.6	0.8	2.3	-0.4	-0.4	-1.5	-1.1	-0.3
Arm fat percentage (right)	0.6	2.4	3.6	-1.9	1.9	-1.4	0.1	-1.7
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.4	0.2	-0.4	1.6	-0.8	1.2
Angina (self-reported)	0.6	0.8	1.7	1.3	0.3	-1.2	-0.5	0.5
Alcohol intake frequency.	0.6	1.5	4.4	1.6	-0.6	0.6	0.0	2.1
Leg pain on walking	0.6	0.8	1.4	0.8	0.9	-1.2	-0.7	0.8
Osteoporosis (self-reported)	0.6	0.7	1.9	-0.2	0.1	0.9	1.4	-0.8
Average weekly champagne plus white wine intake	0.6	0.8	1.9	-0.5	-0.8	-1.0	-1.4	-0.7
Commuting to job workplace: Public transport	0.6	0.7	1.2	1.1	0.6	-1.1	0.4	0.6
Risk taking	0.6	0.9	3.1	-0.9	0.4	-1.8	-0.1	-0.7
Bipolar Disorder or Schizophrenia	0.5	1.3	5.9	0.5	0.2	-2.4	-0.2	0.5
Alzheimer’s Disease (in mother)	0.5	0.6	0.9	1.0	0.6	0.6	0.4	1.0
Allergy or Eczema	0.5	1.4	3.0	-1.1	-0.9	-0.7	-1.3	-1.7
Neuroticism	0.5	1.1	2.6	1.6	-0.7	-0.2	-0.1	1.5
Systolic blood pressure, automated reading	0.5	1.3	4.3	0.2	-1.5	2.1	-0.3	0.0
Supplements: Zinc	0.5	0.5	1.2	1.1	0.4	-0.3	-0.0	1.1
Diabetes (father)	0.5	0.6	1.4	-1.0	0.5	-0.2	0.5	-1.2
Maternal smoking around birth	0.5	0.7	1.4	-0.4	1.2	-0.9	0.4	-1.0
Stomach or abdominal pain in last month	0.5	0.6	2.0	-0.7	-0.3	0.6	1.4	0.1
Had menopause	0.5	0.7	1.2	0.8	-0.6	1.1	1.0	0.0
Financial difficulties in last 2 years	0.5	0.6	2.9	-0.2	1.7	-0.4	0.0	-0.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.2	-0.9	-0.1	1.1	0.3	-1.1
Medication: Paracetamol	0.5	0.9	1.2	-1.0	0.7	-0.9	0.9	-1.1
Gout (self-reported)	0.5	0.6	1.4	-0.9	0.6	-1.2	0.4	-0.6
Body fat percentage	0.5	2.0	3.4	-1.9	1.8	-0.8	0.6	-1.5
Comparative body size at age 10	0.5	1.4	4.2	1.6	0.4	-0.3	-0.6	2.0
Medication: Blood pressure	0.5	0.8	3.4	-0.6	0.2	-1.8	0.1	-0.5
Comparative height size at age 10	0.5	2.6	6.9	2.6	-0.7	1.1	0.6	2.1
Suffer from ‘nerves’	0.5	0.8	1.6	1.0	0.8	0.2	0.7	1.3
Had major operations	0.5	0.5	1.6	-0.2	-0.7	0.4	1.2	-0.7
Osteoarthritis (self-reported)	0.5	0.6	1.8	-0.5	-0.7	0.7	1.3	-0.5
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.5	0.2	-1.2	-1.0	-0.4	0.6
Irritability	0.5	0.8	1.9	-0.9	-0.6	-0.9	0.0	-1.4
Diastolic blood pressure, automated reading	0.5	1.5	3.3	-1.5	-0.3	1.3	0.7	-1.8
Unable to work because of sickness or disability	0.5	0.6	2.5	-0.4	0.1	-1.6	-0.6	-0.4
Pain experienced in last month	0.5	0.8	2.2	0.3	-0.5	-1.1	-1.5	0.3
Basal cell carcinoma (self-reported)	0.5	0.6	1.7	0.5	0.7	-1.3	-0.6	0.4
Intelligence (Savage-Jansen 2018)	0.4	1.2	3.9	1.2	0.4	-0.6	-0.4	2.0
Age at First Birth	0.4	0.5	2.1	0.0	1.4	0.4	0.1	0.6
Hand grip strength (left)	0.4	1.1	2.9	0.5	1.7	-1.4	-0.3	0.4
Average weekly spirits intake	0.4	0.5	1.8	-0.3	0.6	1.3	0.3	-0.1
Sensitivity / hurt feelings	0.4	0.8	3.1	-0.3	-1.8	0.3	0.5	-0.5
Fed-up feelings	0.4	0.8	2.3	-0.0	0.8	-1.0	-1.5	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.2	0.4	1.1	-0.6	0.5	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.0	-0.7	-1.4	0.9	0.8	-0.7
Trunk fat mass	0.4	1.7	3.1	-1.8	1.6	-0.8	0.7	-1.4
Nervous feelings	0.4	0.7	1.8	1.2	-0.0	-0.2	-0.5	1.3
Fluid intelligence score	0.4	0.7	2.4	0.6	0.1	-1.6	-0.8	0.5
Neuroticism score	0.4	0.8	1.4	1.2	-1.1	0.0	-0.1	1.2
Alcohol intake versus 10 years previously	0.4	0.5	1.0	0.9	0.8	-0.4	0.3	1.0
Father’s age at death	0.4	0.6	1.6	-0.1	-1.3	0.9	-0.1	0.6
Happiness	0.4	0.5	1.1	0.7	-1.1	0.5	-0.6	0.3
Illnesses of mother	0.4	0.5	0.9	-0.9	-1.0	-0.4	-0.2	-0.8
Impedance of arm (left)	0.4	2.1	5.0	-1.8	1.3	0.6	0.2	-2.2
Exposure to tobacco smoke at home	0.4	0.5	1.5	-0.5	-1.2	-0.7	-0.2	0.1
Worry too long after embarrassment	0.4	0.6	1.1	-0.6	-1.0	-0.8	-0.4	-0.9
Migraine (self-reported)	0.4	0.5	2.2	-0.3	0.6	-1.5	-0.1	-0.2
Heart disease (mother)	0.4	0.5	1.5	-0.1	0.6	-0.8	1.2	0.2
Number of full sisters	0.4	0.5	1.8	0.6	-1.4	-0.0	-0.6	0.2
Supplements: Vitamin C	0.4	0.4	1.0	0.4	0.8	-1.0	0.5	-0.1
Mood swings	0.4	0.6	1.3	1.1	-0.9	0.4	-0.1	1.0
Loneliness, isolation	0.4	0.6	1.9	-0.6	-0.3	1.4	0.3	-0.8
Illnesses of father: None of the above (group 1)	0.4	0.5	1.0	-0.1	-0.5	0.7	-1.0	0.8
Mother’s age at death	0.4	0.5	0.9	0.6	0.9	0.2	0.0	1.0
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.9	0.1	0.0	-1.4	0.7	0.3
Commuting to job workplace: Cycle	0.4	0.5	1.3	0.5	-1.2	-0.6	-0.4	0.5
Myopia	0.4	0.6	2.1	0.1	-0.6	-0.6	-1.5	0.6
Ulcerative Colitis (UC)	0.3	0.6	1.6	-0.4	-1.3	1.0	0.0	-0.4
Major Depression (MDD)	0.3	0.4	0.8	0.6	-0.3	0.1	0.9	0.8
Body Mass Index (BMI) (2010)	0.3	0.4	1.1	-0.4	0.2	-0.8	-1.1	-0.2
HDL Cholesterol	0.3	0.4	0.9	-0.5	0.9	-0.3	0.9	0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.7	-0.7	0.2	-0.0	1.3	-0.6
Medication for hormone replacement therapy	0.3	0.3	0.8	0.1	0.6	-0.9	-0.5	0.2
Medication: Co-codamol	0.3	0.3	1.4	0.2	-0.2	-0.0	-1.2	0.3
Medication: Metformin	0.3	0.4	1.2	-0.8	-0.0	0.4	1.1	0.1
Hand grip strength (right)	0.3	0.9	2.8	0.4	0.7	-1.0	-1.7	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.7	0.7	-0.1	-0.3	0.0	1.3
Hearing difficulty/problems with background noise	0.3	0.5	1.0	0.6	-1.0	0.9	-0.4	-0.3
Forced vital capacity (FVC)	0.3	1.2	2.8	0.7	1.7	-0.5	0.7	1.3
Impedance of arm (right)	0.3	1.4	2.8	-1.6	1.2	0.4	-0.1	-1.7
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.7	0.1	0.8	-0.5	0.7	-0.2
Arm fat mass (right)	0.3	1.2	2.2	-1.5	1.1	-0.9	0.3	-1.3
Tense / ‘highly strung’	0.3	0.5	1.2	0.8	-0.9	0.0	-0.1	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.7	0.6	0.7	-0.7	-0.3	0.8
Whole body fat mass	0.3	1.3	2.3	-1.5	1.4	-0.9	0.6	-1.2
Arm fat mass (left)	0.3	1.4	2.2	-1.5	1.3	-1.1	0.2	-1.3
Medication: Bendroflumethiazide	0.3	0.5	1.2	1.1	0.1	0.7	-0.0	0.8
Alcohol drinker status: Never	0.3	0.4	1.3	0.1	0.8	-1.1	-0.0	-0.3
Supplements: Calcium	0.3	0.3	1.0	0.5	-0.2	0.5	1.0	0.3
Reaction Time	0.2	0.4	0.7	0.8	-0.6	0.6	-0.4	0.5
Neuroticism (2016)	0.2	0.3	0.6	-0.4	-0.8	0.6	-0.1	-0.6
Schizophrenia (2014)	0.2	0.5	1.3	1.1	-0.5	-0.8	0.1	0.7
BMI	0.2	1.0	1.6	-1.3	0.8	-1.1	0.7	-1.2
Waist Hip Ratio (WHR)	0.2	0.9	1.7	-1.3	0.3	-1.1	-0.6	-0.9
Pack years adult smoking proportion	0.2	0.3	0.6	0.8	0.6	-0.4	0.4	0.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.5	0.2	0.7	0.7	0.5	-0.0
High blood pressure	0.2	0.5	1.4	0.3	1.2	-0.9	0.2	0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	0.2	0.2	0.4	0.6	0.8
Body mass index (BMI)	0.2	0.8	1.5	-1.1	0.8	-1.2	0.3	-0.9
Waist circumference	0.2	0.8	1.8	-1.0	0.4	-1.3	-0.0	-0.9
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	0.3	0.5	-0.6	0.5	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.2	-0.3	-1.1	0.1	0.7	-0.6
Mouth/teeth dental problems	0.2	0.2	0.7	0.4	-0.5	0.3	-0.8	0.1
Trunk fat-free mass	0.2	1.4	2.3	1.4	-1.3	-0.6	-0.7	1.5
Falls in the last year	0.2	0.3	1.0	0.1	-0.7	0.2	1.0	-0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.2	0.2	-0.6	0.2	-1.1	0.7
Trunk predicted mass	0.2	1.4	2.3	1.4	-1.4	-0.6	-0.7	1.5
Birth weight	0.2	0.4	0.8	0.9	0.8	-0.1	-0.4	0.5
High blood pressure (siblings)	0.2	0.3	0.8	-0.6	-0.3	-0.1	-0.2	-0.9
Leg fat percentage (right)	0.2	0.6	1.7	-0.3	1.3	-0.8	0.4	0.4
Medication: Allopurinol	0.2	0.3	0.6	0.4	0.8	-0.7	0.1	0.2
Arm predicted mass (right)	0.2	0.9	1.9	1.2	-0.7	-0.7	-0.1	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.3	-0.1	1.1	0.2	-0.1	1.0
Diabetes diagnosed by doctor	0.2	0.3	1.0	-1.0	-0.6	-0.1	0.4	-0.4
Commuting to job workplace: Walk	0.2	0.2	0.6	-0.2	0.8	-0.0	0.1	-0.4
Mineral and other dietary supplements	0.2	0.3	0.6	-0.2	-0.1	0.8	-0.5	-0.6
Hearing aid user	0.2	0.2	0.4	0.6	0.4	-0.3	0.4	0.6
Leg fat percentage (left)	0.2	0.7	2.0	-0.7	1.4	-0.9	0.3	0.1
Arm fat-free mass (left)	0.2	0.8	1.5	1.1	-1.0	-0.4	-0.1	1.2
Number of operations (self-reported)	0.2	0.3	1.0	-0.6	-1.0	-0.1	-0.1	-0.2
Pack years of smoking	0.2	0.3	1.0	1.0	0.1	-0.2	0.1	0.6
Impedance of whole body	0.2	1.1	1.8	-1.3	0.9	1.1	0.1	-1.3
Depressed Affect (Nagel 2018)	0.1	0.2	0.6	0.8	-0.4	0.4	-0.1	0.5
Neuroticism (Nagel 2018)	0.1	0.1	0.4	0.1	-0.5	-0.6	0.0	-0.1
Schizophrenia (2018)	0.1	0.3	0.9	0.5	-0.5	-1.0	-0.0	0.3
Worry (Nagel 2018)	0.1	0.3	0.8	0.4	0.1	-0.9	0.1	0.6
Breast Cancer	0.1	0.3	0.9	-0.9	-0.2	-0.0	0.0	-0.7
Prostate Cancer	0.1	0.2	0.4	0.6	0.4	-0.6	0.3	0.3
Blood Eosinophil Count	0.1	0.7	1.7	0.9	0.9	-0.2	1.3	-0.3
Heel T-Score	0.1	0.7	1.5	-0.2	-0.7	0.8	0.9	-1.2
Height	0.1	1.6	5.1	0.6	-1.3	1.0	2.3	-0.0
Systolic Blood Pressure	0.1	0.5	2.2	0.2	0.2	1.5	0.1	0.4
Lung FVC	0.1	0.7	1.6	1.2	0.7	-0.2	-0.2	1.2
Tanning	0.1	0.9	2.0	-1.4	-1.3	-0.5	0.7	-0.4
Diabetes (mother)	0.1	0.1	0.3	0.4	0.3	0.2	0.1	0.5
Impedance of leg (right)	0.1	0.6	2.7	-0.2	-0.4	1.6	-0.1	0.4
Leg fat-free mass (left)	0.1	0.4	1.5	-0.1	0.5	-1.2	0.6	-0.1
Supplements: Glucosamine	0.1	0.1	0.4	-0.1	0.1	-0.1	-0.6	-0.1
Sitting height	0.1	0.6	1.7	0.2	-1.3	-0.7	-1.0	0.2
Impedance of leg (left)	0.1	0.7	2.9	-0.7	-0.3	1.7	-0.4	0.0
Leg predicted mass (left)	0.1	0.5	1.6	0.0	0.6	-1.2	0.6	-0.1
Had other major operations	0.1	0.1	0.5	-0.2	-0.1	0.7	-0.1	-0.2
Diabetes (self-reported)	0.1	0.2	0.4	-0.6	-0.2	0.5	0.6	-0.2
Weight	0.1	0.3	1.0	-0.3	0.6	-1.0	0.3	-0.2
Standing height	0.1	0.9	1.9	1.4	-0.7	0.8	0.3	1.2
Hair/balding pattern: Pattern 4	0.1	0.3	0.8	-0.4	-0.1	-0.7	-0.9	-0.6
Forced vital capacity (FVC), Best measure	0.1	0.4	1.0	-0.2	0.6	0.7	1.0	0.6
Arm fat-free mass (right)	0.1	0.6	1.4	0.9	-0.7	-0.5	-0.1	1.2
Qualifications: College or University degree	0.1	0.4	1.0	-0.5	0.6	-1.0	0.4	-0.4
Medication: Ibuprofen	0.1	0.1	0.2	-0.1	0.4	-0.0	0.5	-0.5
Leg fat mass (right)	0.1	0.3	0.8	-0.4	0.8	-0.9	0.3	0.1
Chest pain or discomfort	0.1	0.2	0.6	-0.6	-0.3	-0.8	0.1	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.4	-0.1	0.4	0.2	0.4
Medication: Aspirin	0.1	0.2	0.5	-0.2	-0.3	-0.7	0.0	-0.3
Hypertension (Self-reported)	0.1	0.4	0.5	0.7	0.7	-0.7	0.1	0.7
Whole body fat-free mass	0.1	0.5	0.9	0.7	-0.5	-1.0	-0.2	0.8
Leg fat-free mass (right)	0.1	0.4	1.6	-0.2	0.6	-1.3	0.4	-0.2
Qualifications: nursing, teaching	0.1	0.1	0.6	-0.8	0.1	-0.0	0.0	-0.2
Medication: Aspirin	0.1	0.1	0.3	0.1	-0.6	-0.2	0.3	-0.1
Whole body water mass	0.1	0.5	0.9	0.8	-0.6	-0.9	-0.2	0.9
Leg predicted mass (right)	0.1	0.4	1.6	-0.0	0.6	-1.3	0.4	-0.1
Miserableness	0.1	0.2	0.7	0.8	0.2	0.3	0.5	0.3
Guilty feelings	0.1	0.1	0.3	-0.1	0.1	-0.5	-0.5	-0.2
Medication: Blood pressure	0.1	0.3	0.5	-0.6	0.7	0.4	0.4	-0.4
Basal metabolic rate	0.1	0.3	1.0	0.4	-0.1	-1.0	0.0	0.5
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.4	-0.5	-0.7	0.6	-0.0	-0.6
Leg fat mass (left)	0.1	0.5	1.1	-0.8	0.8	-1.0	0.2	-0.1
Arm predicted mass (left)	0.1	0.6	1.5	0.9	-0.7	-0.5	-0.1	1.2
Hair Pigment	0.0	1.2	3.1	0.0	0.7	1.4	1.8	0.5
Number of incorrect matches in round	0.0	0.0	0.0	-0.1	0.1	0.1	-0.0	-0.1
Hip circumference	0.0	0.2	0.3	-0.4	-0.1	-0.4	0.4	-0.5
Worrier / anxious feelings	0.0	0.1	0.3	-0.0	0.0	-0.2	-0.5	0.0
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	-0.1	-0.1	0.2	-0.3	0.2
Average weekly red wine intake	0.0	0.0	0.2	0.1	-0.1	-0.1	-0.4	0.1

Hub : Genes

HAVCR1

Models

Trait associations