Best TWAS P=5.18e-09 · Best GWAS P=1.81e-15 conditioned to 1.01e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | KIAA1586 | 0.10 | 0.03 | lasso | 5 | 0.03 | 3.2e-02 | 4.7 | -5.8 | 5.2e-09 | -0.32 | 0.12 | 0.34 | TRUE |
| 2 | GTEx | Brain Hypothalamus | ZNF451 | 0.17 | 0.18 | lasso | 2 | 0.14 | 3.1e-04 | 5.5 | 5.5 | 4.5e-08 | 0.33 | 0.05 | 0.82 | FALSE |
| 3 | GTEx | Pancreas | PRIM2 | 0.18 | 0.04 | lasso | 5 | 0.04 | 9.4e-03 | 5.7 | -5.5 | 3.2e-08 | -0.27 | 0.03 | 0.51 | TRUE |
| 4 | GTEx | Testis | DST | 0.17 | 0.12 | lasso | 7 | 0.12 | 4.9e-06 | 5.4 | -5.8 | 8.9e-09 | -0.35 | 0.85 | 0.02 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | BEND6 | 0.05 | 0.08 | blup | 44 | 0.09 | 6.1e-18 | 4.9 | -5.5 | 4.6e-08 | -0.19 | 0.03 | 0.96 | FALSE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | BEND6 | 0.12 | 0.12 | blup | 44 | 0.15 | 5.7e-09 | 4.8 | -5.7 | 1.6e-08 | -0.18 | 0.02 | 0.97 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | BEND6 | 0.11 | 0.10 | lasso | 3 | 0.13 | 1.4e-14 | 4.4 | -5.1 | 3.0e-07 | -0.19 | 0.02 | 0.97 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | BEND6 | 0.06 | 0.08 | blup | 44 | 0.07 | 1.7e-08 | 4.9 | -5.4 | 7.5e-08 | -0.19 | 0.02 | 0.97 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | BEND6 | 0.06 | 0.04 | blup | 44 | 0.05 | 1.1e-03 | 4.3 | -5.2 | 1.8e-07 | -0.19 | 0.04 | 0.89 | FALSE |
| 10 | The Cancer Genome Atlas | Soft Tissue Sarcoma | BEND6 | 0.09 | 0.07 | lasso | 5 | 0.08 | 2.9e-05 | 4.8 | -5.4 | 8.3e-08 | -0.19 | 0.04 | 0.90 | FALSE |