[Hub]/) : Traits : Lung FEV1/FVC ratio : ← →

chr6:33,856,903-36,158,878

Best TWAS P=3.98e-22 · Best GWAS P=1.02e-18 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
54	The Cancer Genome Atlas	Thyroid Carcinoma	TCP11	0.03	0.02	blup	49	0.02	1.6e-03	-8.2	-9.7	4.0e-22	0.64	0.06	0.28	TRUE
27	NTR	Blood	ZNF76	0.01	0.00	blup	424	0.00	3.8e-02	-8.8	8.7	3.3e-18	-0.80	0.01	0.96	TRUE
28	ROSMAP	Brain Pre-frontal Cortex	DEF6	0.04	0.02	bslmm	421	0.02	1.8e-03	-7.9	8.5	2.6e-17	-0.81	0.22	0.72	TRUE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	TCP11	0.03	0.03	blup	49	0.04	6.6e-08	-8.4	-8.2	1.9e-16	0.61	0.13	0.87	TRUE
10	GTEx	Esophagus Muscularis	RPL10A	0.31	0.19	lasso	5	0.18	4.6e-11	-7.9	-8.1	4.5e-16	0.42	0.76	0.24	TRUE
45	The Cancer Genome Atlas	Lung Adenocarcinoma	RPL10A	0.02	0.02	lasso	2	0.02	3.8e-03	-8.0	-8.0	1.5e-15	0.34	0.01	0.91	TRUE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPL10A	0.03	0.00	blup	55	0.01	1.4e-03	-7.9	-8.0	1.7e-15	0.45	0.01	0.87	TRUE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZNF76	0.03	0.02	lasso	3	0.02	3.5e-03	-6.6	7.9	2.5e-15	-0.72	0.04	0.86	TRUE
9	GTEx	Esophagus Mucosa	RPL10A	0.14	0.10	enet	17	0.09	2.1e-06	-8.0	-6.8	1.1e-11	0.25	0.71	0.25	TRUE
3	CommonMind	Brain Pre-frontal Cortex	RPL10A	0.21	0.09	enet	30	0.11	2.6e-13	-8.0	-6.4	1.7e-10	0.29	0.74	0.26	TRUE
19	GTEx	Thyroid	C6orf106	0.09	0.01	enet	29	0.01	1.1e-01	4.9	6.4	2.1e-10	-0.05	0.10	0.04	TRUE
29	ROSMAP	Brain Pre-frontal Cortex	ZNF76	0.04	0.00	blup	424	0.02	2.1e-03	-8.3	9.5	2.2e-21	-0.81	0.08	0.85	FALSE
46	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TCP11	0.03	0.03	blup	49	0.03	3.5e-04	-8.1	-9.5	2.4e-21	0.66	0.21	0.46	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FANCE	0.03	0.02	bslmm	420	0.01	1.7e-02	-8.1	-9.2	4.7e-20	0.55	0.31	0.19	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	TCP11	0.05	0.04	blup	49	0.06	1.3e-07	-8.1	-9.1	1.1e-19	0.56	0.35	0.64	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TCP11	0.03	0.02	blup	49	0.02	1.7e-03	-7.6	-9.1	1.2e-19	0.59	0.22	0.48	FALSE
33	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RPL10A	0.03	0.00	blup	54	0.02	6.0e-03	-7.8	-8.6	5.7e-18	0.52	0.01	0.74	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	TCP11	0.03	0.03	lasso	3	0.04	3.8e-05	-8.4	-8.6	1.2e-17	0.67	0.09	0.70	FALSE
32	YFS	Blood	ZNF76	0.05	0.08	lasso	4	0.07	6.7e-23	-8.3	8.3	9.8e-17	-0.87	0.20	0.80	FALSE
47	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TCP11	0.05	0.07	lasso	2	0.07	1.9e-05	-8.2	-8.2	1.6e-16	0.58	0.20	0.62	FALSE
48	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TCP11	0.08	0.11	lasso	2	0.11	3.4e-05	-8.2	-8.2	2.3e-16	0.58	0.17	0.38	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RPL10A	0.07	0.07	lasso	2	0.06	9.9e-08	-8.0	-8.2	3.2e-16	0.35	0.00	1.00	FALSE
15	GTEx	Nerve Tibial	RPL10A	0.14	0.12	lasso	3	0.12	9.7e-09	-7.9	-8.0	1.7e-15	0.42	0.78	0.22	FALSE
5	GTEx	Artery Aorta	RPL10A	0.20	0.12	lasso	5	0.11	8.8e-07	-7.9	-7.9	3.7e-15	0.34	0.73	0.24	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	RPL10A	0.05	0.07	enet	4	0.04	1.2e-04	-7.9	-7.9	3.7e-15	0.38	0.01	0.99	FALSE
6	GTEx	Artery Tibial	RPL10A	0.11	0.08	lasso	2	0.09	1.5e-07	-8.0	-7.9	3.9e-15	0.29	0.80	0.20	FALSE
12	GTEx	Muscle Skeletal	RPL10A	0.10	0.05	enet	17	0.04	3.9e-05	-8.0	-7.6	2.8e-14	0.39	0.60	0.18	FALSE
23	METSIM	Adipose	RPL10A	0.18	0.13	lasso	15	0.13	3.4e-19	-7.9	-7.6	3.3e-14	0.38	0.79	0.21	FALSE
18	GTEx	Testis	ZNF76	0.15	0.14	enet	8	0.12	4.4e-06	-7.2	7.5	5.7e-14	-0.67	0.72	0.24	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	SCUBE3	0.03	0.01	blup	62	0.03	8.9e-04	-7.7	7.5	6.5e-14	-0.82	0.03	0.81	FALSE
8	GTEx	Colon Transverse	RPL10A	0.12	0.05	lasso	4	0.05	2.5e-03	-8.0	-7.5	7.9e-14	0.35	0.20	0.33	FALSE
20	GTEx	Thyroid	RPL10A	0.16	0.09	lasso	11	0.07	8.9e-06	-6.7	-7.2	7.9e-13	0.21	0.86	0.03	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	DEF6	0.04	0.01	blup	50	0.03	6.2e-04	-8.3	7.1	1.1e-12	-0.77	0.01	0.95	FALSE
43	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ZNF76	0.08	0.05	lasso	10	0.07	4.9e-04	-7.5	-7.1	1.3e-12	0.75	0.04	0.52	FALSE
4	GTEx	Adipose Subcutaneous	RPL10A	0.06	0.02	enet	27	0.03	2.6e-03	-6.6	-7.0	2.2e-12	0.33	0.25	0.25	FALSE
21	GTEx	Whole Blood	DEF6	0.14	0.05	lasso	4	0.03	9.9e-04	-8.3	7.0	2.2e-12	-0.72	0.19	0.78	FALSE
13	GTEx	Nerve Tibial	DEF6	0.15	0.00	lasso	8	0.00	1.6e-01	-8.4	7.0	3.2e-12	-0.73	0.11	0.39	FALSE
31	YFS	Blood	RPL10A	0.24	0.11	lasso	11	0.13	4.4e-39	-7.9	-6.9	3.8e-12	0.34	0.76	0.24	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	RPL10A	0.09	0.03	enet	19	0.07	1.1e-07	-7.9	-6.9	4.4e-12	0.40	0.01	0.99	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	TEAD3	0.15	0.06	lasso	5	0.08	2.5e-05	-6.5	-6.9	6.7e-12	0.24	0.76	0.04	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	C6orf106	0.30	0.26	bslmm	372	0.33	9.3e-44	4.9	6.7	2.6e-11	-0.12	1.00	0.00	FALSE
14	GTEx	Nerve Tibial	C6orf106	0.11	0.07	enet	17	0.07	1.3e-05	4.6	6.2	6.4e-10	-0.04	0.71	0.01	FALSE
1	CommonMind	Brain Pre-frontal Cortex	C6orf106	0.29	0.21	bslmm	382	0.23	6.9e-28	4.8	6.2	6.9e-10	-0.09	1.00	0.00	FALSE
26	NTR	Blood	DEF6	0.03	0.02	bslmm	420	0.02	7.2e-07	-8.3	6.1	8.6e-10	-0.73	0.20	0.80	FALSE
25	NTR	Blood	C6orf106	0.03	0.02	lasso	6	0.02	7.2e-07	4.9	6.1	1.3e-09	-0.08	1.00	0.00	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TCP11	0.03	0.00	blup	49	0.01	8.8e-03	-8.1	-6.1	1.3e-09	0.56	0.08	0.20	FALSE
16	GTEx	Pancreas	C6orf106	0.14	0.11	enet	11	0.13	2.8e-06	4.6	5.9	2.9e-09	-0.06	0.86	0.01	FALSE
36	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TCP11	0.07	0.01	enet	8	0.01	8.2e-02	-8.0	-5.9	3.7e-09	0.37	0.08	0.15	FALSE
22	METSIM	Adipose	C6orf106	0.04	0.02	blup	381	0.02	7.7e-04	5.3	5.9	4.7e-09	-0.15	0.41	0.06	FALSE
7	GTEx	Colon Transverse	C6orf106	0.15	0.05	lasso	1	0.03	1.5e-02	5.8	5.8	7.6e-09	-0.15	0.17	0.05	FALSE
44	The Cancer Genome Atlas	Lung Adenocarcinoma	C6orf106	0.03	0.03	lasso	3	0.01	7.6e-03	5.3	5.7	9.7e-09	-0.02	0.01	0.93	FALSE
11	GTEx	Lung	RPL10A	0.21	0.09	enet	53	0.09	1.2e-07	-7.9	-5.6	2.0e-08	0.29	0.73	0.24	FALSE
24	METSIM	Adipose	ZNF76	0.11	0.07	blup	405	0.06	6.3e-10	-7.8	5.2	1.6e-07	-0.76	0.55	0.46	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	C6orf106	0.04	0.05	lasso	4	0.03	8.1e-05	4.9	5.1	3.0e-07	0.03	0.02	0.97	FALSE