[Hub]/) : Traits : Lung FVC : ← →

chr9:138,403,706-140,031,290

Best TWAS P=1.52e-26 · Best GWAS P=1.92e-26 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	INPP5E	0.18	0.14	enet	21	0.21	1.6e-24	-6.3	5.6	2.2e-08	0.00	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	QSOX2	0.18	0.11	lasso	4	0.10	1.0e-12	6.7	9.1	1.2e-19	-0.71	0.68	0.32	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SNAPC4	0.06	0.04	lasso	2	0.05	9.0e-07	-6.3	6.4	1.3e-10	0.01	0.96	0.00	FALSE
4	GTEx	Adipose Subcutaneous	SDCCAG3	0.13	0.00	enet	21	0.04	4.8e-04	-5.3	5.3	9.4e-08	-0.03	0.21	0.03	FALSE
5	GTEx	Adrenal Gland	INPP5E	0.18	0.02	enet	23	0.10	2.2e-04	-6.4	5.5	3.1e-08	0.01	0.22	0.05	FALSE
6	GTEx	Artery Tibial	SDCCAG3	0.05	0.00	lasso	4	0.00	2.2e-01	3.9	5.5	3.6e-08	0.01	0.28	0.10	FALSE
7	GTEx	Brain Cerebellar Hemisphere	INPP5E	0.25	0.23	enet	6	0.17	3.4e-05	-5.0	6.0	2.1e-09	0.04	0.68	0.02	FALSE
8	GTEx	Brain Cerebellum	INPP5E	0.40	0.30	enet	20	0.29	3.6e-09	-4.6	5.6	2.1e-08	0.02	1.00	0.00	FALSE
9	GTEx	Cells Transformed fibroblasts	QSOX2	0.40	0.25	enet	11	0.30	5.2e-23	-10.6	9.7	2.0e-22	-0.89	0.00	1.00	FALSE
10	GTEx	Cells Transformed fibroblasts	SDCCAG3	0.12	0.03	enet	21	0.06	5.4e-05	-5.3	6.2	7.7e-10	0.01	0.98	0.00	FALSE
11	GTEx	Colon Sigmoid	INPP5E	0.22	0.10	lasso	3	0.01	1.6e-01	-6.3	6.4	1.5e-10	0.00	0.54	0.04	FALSE
12	GTEx	Esophagus Muscularis	QSOX2	0.16	0.07	lasso	4	0.06	1.4e-04	6.6	5.5	3.6e-08	-0.35	0.54	0.03	FALSE
13	GTEx	Liver	PMPCA	0.31	0.00	lasso	5	0.06	8.9e-03	2.3	-6.1	8.6e-10	0.01	0.09	0.05	FALSE
14	GTEx	Lung	INPP5E	0.10	0.05	enet	13	0.04	6.1e-04	-4.6	5.4	7.4e-08	0.01	0.76	0.01	FALSE
15	GTEx	Lung	CARD9	0.08	0.04	enet	6	0.04	2.5e-04	-5.9	-6.7	2.5e-11	-0.02	0.89	0.00	FALSE
16	GTEx	Skin Sun Exposed Lower leg	INPP5E	0.10	0.10	lasso	2	0.09	5.2e-08	-5.0	5.3	1.0e-07	0.02	1.00	0.00	FALSE
17	GTEx	Spleen	PMPCA	0.24	0.15	lasso	2	0.10	1.7e-03	-5.4	-5.8	5.6e-09	0.01	0.07	0.10	FALSE
18	GTEx	Testis	SDCCAG3	0.15	0.09	lasso	4	0.13	3.3e-06	-5.3	5.5	4.8e-08	0.02	0.75	0.03	FALSE
19	GTEx	Thyroid	INPP5E	0.23	0.35	enet	16	0.37	8.2e-30	-5.3	6.2	6.5e-10	0.01	1.00	0.00	FALSE
20	GTEx	Thyroid	SDCCAG3	0.16	0.11	lasso	3	0.12	9.4e-10	-5.3	5.5	3.7e-08	0.02	1.00	0.00	FALSE
21	GTEx	Whole Blood	SDCCAG3	0.07	0.03	enet	6	0.02	3.4e-03	-6.4	6.7	2.8e-11	0.01	0.63	0.09	FALSE
22	GTEx	Whole Blood	CARD9	0.08	0.07	lasso	1	0.05	4.2e-05	-6.4	-6.4	1.2e-10	0.00	0.97	0.00	FALSE
23	METSIM	Adipose	CARD9	0.04	0.05	enet	6	0.06	5.9e-09	3.9	-5.2	1.8e-07	0.00	1.00	0.00	FALSE
24	YFS	Blood	CARD9	0.22	0.37	lasso	5	0.39	1.3e-137	-6.5	-6.6	4.3e-11	-0.01	1.00	0.00	FALSE
25	YFS	Blood	INPP5E	0.33	0.55	lasso	6	0.57	2.9e-235	-5.2	5.2	2.5e-07	0.02	1.00	0.00	FALSE
26	YFS	Blood	PMPCA	0.03	0.01	lasso	5	0.02	2.7e-07	-5.3	-5.4	7.6e-08	0.00	0.99	0.00	FALSE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	QSOX2	0.05	0.03	blup	32	0.03	2.8e-07	-10.6	8.7	3.2e-18	-0.76	0.00	1.00	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEC16A	0.02	0.00	blup	69	0.01	1.0e-03	-4.6	6.1	1.2e-09	-0.05	0.08	0.60	FALSE
29	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	INPP5E	0.25	0.10	lasso	3	0.09	4.9e-05	-5.2	5.4	5.5e-08	0.03	0.16	0.58	FALSE
30	The Cancer Genome Atlas	Colon Adenocarcinoma	INPP5E	0.11	0.08	lasso	2	0.08	3.4e-05	-5.2	5.4	7.8e-08	0.03	0.06	0.60	FALSE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	SDCCAG3	0.08	0.01	lasso	4	0.02	3.1e-02	-5.2	5.8	5.2e-09	0.02	0.03	0.42	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	QSOX2	0.10	0.03	enet	6	0.06	3.4e-07	4.4	7.0	2.4e-12	-0.74	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	QSOX2	0.04	0.01	enet	4	0.03	3.6e-04	-10.6	9.4	3.3e-21	-0.87	0.00	0.98	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SDCCAG3	0.04	0.05	enet	6	0.04	5.1e-05	-5.2	6.0	1.8e-09	0.01	0.20	0.78	FALSE
35	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	INPP5E	0.07	0.04	blup	54	0.07	6.0e-05	-5.8	6.3	2.5e-10	0.01	0.03	0.89	FALSE
36	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	QSOX2	0.10	0.11	lasso	2	0.10	1.6e-06	-10.6	10.7	1.5e-26	-1.00	0.00	1.00	TRUE
37	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SDCCAG3	0.05	0.01	blup	61	0.01	5.9e-02	-6.3	7.2	7.8e-13	0.01	0.02	0.70	TRUE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	GPSM1	0.06	0.01	enet	11	0.02	1.0e-03	-6.4	5.3	1.1e-07	0.01	0.01	0.90	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	QSOX2	0.06	0.05	lasso	2	0.05	2.5e-06	6.7	9.2	2.4e-20	-0.72	0.02	0.96	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	SNAPC4	0.13	0.05	enet	7	0.06	1.7e-07	-5.8	5.8	7.5e-09	0.02	0.23	0.72	FALSE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	QSOX2	0.05	0.05	enet	4	0.05	2.7e-06	-10.6	10.6	2.6e-26	-0.94	0.00	1.00	FALSE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	QSOX2	0.08	0.07	lasso	4	0.08	1.2e-08	-10.6	10.4	3.9e-25	-0.92	0.00	1.00	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	SDCCAG3	0.08	0.05	lasso	2	0.05	3.3e-06	-5.2	6.1	1.4e-09	0.01	0.07	0.92	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	SEC16A	0.08	0.10	lasso	4	0.08	1.9e-08	-6.0	6.2	7.6e-10	0.01	0.04	0.96	FALSE
45	The Cancer Genome Atlas	Skin Cutaneous Melanoma	QSOX2	0.28	0.01	enet	4	0.05	1.6e-02	-10.6	10.1	5.1e-24	-0.88	0.00	0.65	FALSE
46	The Cancer Genome Atlas	Testicular Germ Cell Tumors	INPP5E	0.10	0.06	blup	54	0.08	8.1e-04	-5.0	6.8	1.4e-11	0.02	0.03	0.72	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	INPP5E	0.11	0.16	lasso	3	0.16	2.4e-15	-5.5	6.2	6.0e-10	0.01	0.16	0.84	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	QSOX2	0.06	0.01	blup	32	0.05	1.6e-05	4.4	9.1	1.3e-19	-0.62	0.01	0.84	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	SDCCAG3	0.16	0.14	lasso	4	0.12	8.2e-12	-5.2	5.2	1.7e-07	0.01	0.94	0.06	FALSE