Best TWAS P=3.36e-17 · Best GWAS P=1.88e-15 conditioned to 0.868
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PLEKHM1P | 0.24 | 0.26 | lasso | 6 | 0.27 | 8.0e-33 | 7.5 | -7.7 | 1.3e-14 | -0.70 | 0.07 | 0.93 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | CD79B | 0.15 | 0.16 | enet | 9 | 0.17 | 3.5e-14 | -4.8 | 5.2 | 1.7e-07 | -0.03 | 0.08 | 0.92 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | CD79B | 0.04 | 0.07 | lasso | 2 | 0.03 | 4.2e-02 | -4.8 | 5.2 | 2.3e-07 | 0.01 | 0.02 | 0.50 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | SMURF2 | 0.17 | 0.13 | enet | 8 | 0.13 | 3.7e-10 | 7.8 | 8.4 | 3.4e-17 | 0.93 | 0.01 | 0.99 | TRUE |
| 5 | GTEx | Esophagus Muscularis | PSMC5 | 0.12 | 0.08 | lasso | 3 | 0.07 | 3.8e-05 | -5.3 | -5.3 | 1.0e-07 | -0.03 | 0.01 | 0.98 | TRUE |
| 6 | GTEx | Esophagus Muscularis | hsa-mir-6080 | 0.14 | 0.03 | lasso | 5 | 0.03 | 9.4e-03 | -3.2 | -5.3 | 1.3e-07 | -0.32 | 0.06 | 0.28 | FALSE |
| 7 | GTEx | Pancreas | MILR1 | 0.18 | 0.01 | lasso | 7 | 0.03 | 1.3e-02 | 7.9 | 5.6 | 2.8e-08 | 0.68 | 0.02 | 0.73 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | hsa-mir-6080 | 0.11 | 0.10 | lasso | 2 | 0.08 | 1.7e-07 | 7.9 | -8.2 | 3.7e-16 | -0.99 | 0.01 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PLEKHM1P | 0.01 | 0.01 | enet | 7 | 0.01 | 1.9e-02 | 7.9 | -5.7 | 1.1e-08 | -0.48 | 0.00 | 0.92 | FALSE |
| 10 | The Cancer Genome Atlas | Glioblastoma Multiforme | PLEKHM1P | 0.08 | 0.04 | blup | 7 | 0.04 | 2.7e-02 | 7.4 | -7.7 | 1.4e-14 | -0.68 | 0.00 | 0.46 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PLEKHM1P | 0.08 | 0.03 | enet | 4 | 0.04 | 4.0e-05 | 7.5 | -6.1 | 1.1e-09 | -0.55 | 0.02 | 0.90 | FALSE |
| 12 | The Cancer Genome Atlas | Lung Adenocarcinoma | PLEKHM1P | 0.02 | 0.01 | blup | 7 | 0.02 | 4.7e-03 | 7.9 | -7.9 | 3.7e-15 | -0.69 | 0.00 | 0.75 | FALSE |
| 13 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | SMURF2 | 0.10 | 0.01 | blup | 14 | 0.05 | 5.5e-03 | 5.8 | 6.9 | 5.4e-12 | 0.86 | 0.00 | 0.80 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PLEKHM1P | 0.02 | 0.02 | blup | 7 | 0.02 | 6.7e-03 | 7.9 | -8.0 | 1.6e-15 | -0.71 | 0.00 | 0.86 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PSMC5 | 0.04 | 0.03 | lasso | 1 | 0.03 | 5.6e-04 | -5.2 | -5.2 | 1.9e-07 | -0.02 | 0.01 | 0.95 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | CCDC46 | 0.06 | 0.01 | blup | 282 | 0.03 | 7.6e-04 | -5.4 | -5.4 | 6.1e-08 | -0.01 | 0.06 | 0.91 | TRUE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | PLEKHM1P | 0.04 | 0.03 | blup | 7 | 0.05 | 1.2e-05 | 7.5 | -7.5 | 5.4e-14 | -0.69 | 0.01 | 0.99 | FALSE |