Hub : Genes

SMURF2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.173	0.0560	0.00021	0.129	NA	0.133	NA	0.115	6.6e-10	NA	3.7e-10	NA	6.3e-09
2	GTEx	Vagina	0.321	0.1260	0.00920	-0.004	NA	0.064	NA	0.002	4.1e-01	NA	1.4e-02	NA	2.9e-01
3	METSIM	Adipose	0.096	0.0337	0.00003	0.009	0.024	0.028	0.016	0.011	1.3e-02	0.00012	3.6e-05	0.0015	6.6e-03
4	TCGA	Pancreatic Adenocarcinoma	0.102	0.0590	0.00180	0.006	0.045	-0.003	NA	0.006	1.7e-01	0.00550	4.7e-01	NA	1.7e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.1	0.2	0.4	0.6	0.0	-0.7	0.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.9	-0.3	0.0	-1.0	-0.1
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	-0.0	-0.6	-0.1	0.7
Depression (Nagel 2018)	0.2	0.3	0.5	-0.7	-0.5	-0.3	-0.5
Intelligence (Savage-Jansen 2018)	0.5	1.6	2.8	1.7	1.6	-1.0	0.3
Neuroticism (Nagel 2018)	0.6	1.4	2.7	-1.4	-1.6	0.9	-0.6
Schizophrenia (2018)	0.1	0.3	0.8	-0.9	0.0	-0.4	-0.3
Schizophrenia vs Biploar Disorder	0.9	1.2	3.3	0.8	0.0	-1.8	0.9
Worry (Nagel 2018)	1.2	2.5	6.6	-1.3	-2.6	1.2	0.3
Alzheimer’s Disease (in mother)	0.6	0.7	1.1	0.8	0.2	-1.0	1.1
Alzheimer’s Disease (in father)	0.5	0.6	1.7	-0.2	-0.7	1.3	-0.3
Alzheimer’s Disease (including proxy)	0.0	0.1	0.1	-0.2	-0.3	0.0	-0.3
Crohns Disease (2017)	0.1	0.3	0.6	-0.7	0.0	0.5	-0.6
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	0.3	0.2	-0.6	0.5
Ulcerative Colitis (UC)	0.3	0.5	1.4	0.3	0.2	-1.2	0.8
Major Depression (MDD)	1.7	2.0	3.6	1.5	0.0	-1.9	1.5
Reaction Time	0.3	0.5	1.2	0.7	0.6	-1.1	0.2
Verbal and Numeric Reasoning (VNR)	1.5	3.5	6.9	2.4	2.6	-1.0	0.7
Breast Cancer	0.7	1.6	2.5	1.4	1.3	-1.6	0.6
Ovarian Cancer	0.2	0.2	0.4	-0.5	0.4	-0.3	-0.7
Prostate Cancer	0.4	0.5	0.8	-0.3	-0.9	-0.9	-0.7
Age at First Birth	0.1	0.2	0.5	0.5	0.0	0.1	-0.7
Bipolar Disorder (2011)	0.1	0.0	0.2	0.4	0.0	0.0	-0.0
Body Mass Index (BMI) (2010)	0.6	0.8	2.5	-1.6	0.0	0.3	-0.7
Coronary Artery Disease (CAD)	0.6	0.7	2.4	1.5	0.0	-0.7	-0.4
Crohns Disease (2012)	0.2	0.3	1.1	0.3	0.0	-1.1	0.3
Mean Putamen Volume	0.4	0.5	1.8	-0.2	0.0	1.3	0.2
Fasting Glucose	0.2	0.3	0.5	-0.7	0.0	0.7	0.2
HbA1C	0.1	0.1	0.2	-0.0	0.0	-0.2	0.5
HDL Cholesterol	1.5	2.5	5.7	-2.1	0.0	-0.2	-2.4
LDL Cholesterol	0.4	0.7	2.4	-0.3	0.0	1.5	0.4
Lupus	0.5	0.8	2.0	-0.5	-1.4	0.7	0.5
Neuroticism (2016)	0.3	0.4	0.7	0.7	0.5	-0.8	0.3
Primary Biliary Cirrhosis	2.3	3.2	4.8	-2.2	-1.2	-1.5	-2.1
Rheumatoid Arthritis	0.0	0.0	0.1	0.2	0.0	-0.0	0.3
Schizophrenia (2014)	0.5	1.1	4.2	-0.2	0.0	-2.1	0.5
Triglycerides	0.9	1.4	3.4	1.3	0.0	-0.7	1.8
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.0	-1.4	0.0	0.3	1.1
Ulcerative Colitis	0.3	0.5	1.3	0.2	0.0	-0.7	1.2
Blood Eosinophil Count	0.3	2.2	3.2	-1.6	-1.6	1.8	-0.6
Blood Platelet Count	0.1	0.8	2.8	1.7	0.4	-0.2	0.2
Blood Red Count	1.2	11.6	18.3	-4.3	-3.0	1.3	-4.2
Blood White Count	0.3	2.2	5.9	-1.6	-0.6	0.4	-2.4
Heel T-Score	0.8	6.6	11.5	-3.2	-3.4	1.0	1.9
BMI	1.3	7.4	12.4	-3.0	-1.4	2.5	-3.5
Height	2.3	44.2	85.0	9.2	7.8	-3.2	4.6
Waist Hip Ratio (WHR)	0.3	1.3	4.1	0.8	2.0	-0.6	0.2
Systolic Blood Pressure	2.4	12.1	29.8	-3.4	-5.5	2.6	0.3
Smoking Status	0.2	0.6	1.2	-0.5	-1.1	-0.8	-0.3
Allergy or Eczema	0.2	0.5	1.4	0.4	0.8	0.2	1.2
Cardiovascular Disease	1.3	4.3	11.2	-1.5	-3.4	1.8	0.6
Hypothyroidism (self reported)	0.1	0.2	0.4	-0.3	0.4	0.7	-0.5
Respiratory disease	0.8	1.8	4.0	-2.0	-1.0	1.5	-0.1
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.1	0.1	0.2	0.4	0.3
Lung FEV1/FVC ratio	8.4	42.6	76.2	-8.7	-3.0	3.1	-8.7
Lung FVC	6.4	32.7	71.1	8.4	3.3	-1.0	6.9
Neuroticism	0.5	1.2	2.5	0.2	-1.6	-0.9	1.3
Chronotype (morning person)	0.2	0.5	0.7	-0.2	-0.8	0.9	-0.8
Hair Pigment	0.0	1.0	2.1	-1.3	-0.2	-0.4	-1.4
Tanning	0.1	0.8	2.3	-0.7	-1.5	0.1	0.7
Hand grip strength (left)	0.5	1.2	2.8	0.3	1.7	1.1	-1.0
Number of treatments/medications taken	1.2	2.1	4.6	-1.1	-1.6	2.1	0.1
Average weekly spirits intake	0.4	0.4	0.8	-0.9	-0.7	0.7	-0.1
Sensitivity / hurt feelings	0.3	0.6	1.0	-0.8	-1.0	-0.8	-0.3
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	-0.1	-0.1	-0.4	-0.5
Hearing difficulty/problems: Yes	0.8	1.3	2.0	-1.1	-1.4	-1.3	-0.7
Relative age of first facial hair	0.5	0.9	3.0	-0.2	-1.7	0.4	0.7
Other serious medical condition/disability diagnosed by doctor	2.1	2.7	6.5	1.8	0.8	-0.6	2.5
Ever used hormone-replacement therapy (HRT)	0.8	1.1	2.1	-1.4	0.3	0.5	-1.3
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	0.5	-0.0	-0.3	-0.1
Systolic blood pressure, automated reading	2.4	7.1	22.0	-1.4	-4.7	2.0	0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.1	0.3	0.1	1.1	-0.0
Angina	1.4	1.9	6.7	0.1	-0.4	2.6	0.9
Medication for hormone replacement therapy	0.4	0.4	1.3	-0.4	0.2	1.1	-0.2
Vitamin and mineral supplements	0.8	1.1	3.9	-0.6	-0.4	2.0	0.0
Supplements: Zinc	0.5	0.5	1.5	-0.4	0.6	0.3	-1.2
Medication: Co-codamol	0.3	0.4	1.3	0.1	-0.4	0.2	1.1
Medication: Metformin	0.4	0.6	1.4	1.2	-0.1	1.0	-0.1
Diabetes (father)	1.9	2.3	4.1	-1.7	-0.7	2.0	-1.3
Diabetes (mother)	0.8	1.1	3.1	-0.7	0.2	1.8	-0.8
Severe depression (siblings)	0.5	0.6	1.2	0.2	1.1	0.7	-0.8
Pack years adult smoking proportion	0.2	0.3	1.0	-0.6	0.1	0.1	-1.0
Impedance of leg (right)	0.9	4.4	10.1	-3.2	-1.5	1.7	-1.6
Leg fat-free mass (left)	1.4	7.3	14.7	3.8	3.2	-0.9	1.8
Trunk fat percentage	0.7	2.9	3.8	-1.9	-2.0	1.4	-1.5
Hand grip strength (right)	0.5	1.3	3.7	0.4	1.9	0.8	-0.9
Townsend deprivation index at recruitment	0.1	0.2	0.3	-0.3	-0.1	0.5	0.5
Current tobacco smoking	0.5	0.8	1.3	0.7	1.1	-1.1	-0.2
Average weekly fortified wine intake	1.5	1.8	2.4	1.5	1.3	-1.5	1.0
Maternal smoking around birth	2.6	3.7	6.5	-2.3	-1.4	-1.2	-2.6
Fed-up feelings	0.3	0.5	1.5	0.1	-1.2	-0.8	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.1	-1.0	-0.3	-0.7	-0.7
Relative age voice broke	1.0	1.6	2.8	-0.9	-1.7	-1.4	-0.8
Taking other prescription medications	1.1	1.7	4.8	0.5	-0.4	2.2	1.3
Age when periods started (menarche)	0.6	1.5	4.1	-1.2	0.3	-2.0	-0.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.3	-0.4	-0.5	0.6	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	4.5	0.4	-1.4	-0.4	2.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.0	1.0	0.5	0.1	1.0
Qualifications: CSEs or equivalent	1.5	1.9	5.2	0.5	2.3	-1.3	0.7
Serious illness, injury or assault to yourself	3.5	4.3	10.5	3.2	1.5	-0.5	2.1
High blood pressure	1.3	3.8	12.4	-1.1	-3.5	1.0	0.7
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.6	-0.3	0.8	0.2	0.6
Multivitamins +/- minerals	0.9	1.1	3.7	0.3	0.3	-1.9	0.7
Stomach or abdominal pain in last month	0.2	0.2	0.5	-0.7	0.2	-0.1	-0.6
Supplements: Glucosamine	0.5	0.6	1.2	-0.3	1.1	-0.9	-0.6
Diverticular disease/diverticulitis (self-reported)	1.7	2.1	3.9	1.6	1.0	-0.8	2.0
Medication: Atenolol	1.3	1.6	2.8	-1.5	-1.3	1.7	0.0
Medication: Levothyroxine sodium	0.3	0.5	0.9	-0.9	0.9	-0.2	-0.5
Sitting height	0.4	2.5	6.5	2.5	1.7	0.1	0.9
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	0.1	0.6	0.5	0.8
High blood pressure (mother)	0.4	0.6	1.3	-1.1	0.1	0.9	-0.4
Body mass index (BMI)	0.6	2.6	3.1	-1.7	-1.6	1.4	-1.8
Impedance of leg (left)	0.7	3.3	7.9	-2.8	-1.1	1.4	-1.5
Leg predicted mass (left)	1.4	7.3	15.1	3.9	3.1	-1.1	1.9
Trunk fat mass	0.2	0.8	1.2	-0.8	-0.9	0.8	-1.1
Waist circumference	0.1	0.4	1.0	-0.2	-0.4	0.6	-1.0
Number of incorrect matches in round	2.2	3.7	9.2	-1.5	-3.0	1.7	0.6
Past tobacco smoking	2.6	4.8	11.0	2.3	3.3	0.9	1.4
Alcohol usually taken with meals	0.3	0.4	1.0	0.3	0.8	0.1	1.0
Nervous feelings	1.2	2.2	5.4	-1.6	-2.3	1.0	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.6	-1.6	-0.1	-0.1	-1.4
Hearing difficulty/problems with background noise	0.7	1.2	4.0	-0.4	-2.0	-0.4	0.7
Hair/balding pattern: Pattern 2	2.1	2.6	5.1	-2.2	0.5	0.6	-2.2
Had menopause	1.4	1.8	3.2	-1.0	0.1	-1.7	-1.8
Had other major operations	0.4	0.5	0.9	1.0	-0.8	-0.2	0.7
Forced vital capacity (FVC)	9.4	36.3	71.6	8.5	6.1	-1.2	5.9
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.6	0.2	-0.7	-0.3	1.6
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	1.9	1.2	0.1	1.2	1.4
Qualifications: None of the above	1.7	3.6	5.2	-2.3	-1.6	1.3	-2.3
Financial difficulties in last 2 years	0.1	0.2	0.5	0.2	0.2	0.7	-0.5
Mouth/teeth dental problems	0.5	0.8	2.7	-0.3	0.3	-1.7	-0.6
Heart attack	0.3	0.4	1.3	0.3	-0.6	1.1	0.2
Allergy	0.2	0.5	1.0	0.5	-0.4	-1.0	-0.8
Pain all over the body in last month	2.0	2.1	3.8	0.1	-1.9	1.3	1.7
Diabetes (self-reported)	0.3	0.4	1.1	-0.5	-0.0	1.1	-0.6
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.8	0.3	0.6	1.7	1.3
Medication: Ramipril	1.6	2.1	6.9	-0.3	-2.6	0.4	1.1
Medication: Simvastatin	1.0	1.4	3.6	-0.5	-1.4	1.9	0.3
Fluid intelligence score	0.5	1.0	1.5	1.2	1.0	-1.2	0.4
Illnesses of siblings	2.0	2.8	5.3	1.8	0.9	-2.3	1.4
Neuroticism score	0.3	0.6	1.8	0.3	-1.3	-0.3	0.8
Weight	0.1	0.6	1.4	1.2	0.9	0.2	0.1
Impedance of arm (right)	0.1	0.5	1.4	0.6	0.1	0.5	1.2
Arm fat percentage (right)	0.6	2.5	3.4	-1.8	-1.8	1.1	-1.5
Trunk fat-free mass	1.6	9.3	16.4	3.9	4.0	-1.8	1.6
Hip circumference	0.1	0.3	0.9	0.2	0.1	0.9	-0.5
Time employed in main current job	2.4	2.7	6.4	-2.1	-0.3	-0.5	-2.5
Alcohol intake versus 10 years previously	0.3	0.4	0.9	1.0	-0.3	0.1	0.9
Father’s age at death	0.6	0.8	1.6	-0.4	1.3	-0.7	-0.9
Worrier / anxious feelings	1.1	2.0	4.2	0.7	-2.0	-0.3	1.8
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	4.3	0.2	-1.0	-2.1	0.4
Falls in the last year	0.6	0.9	1.8	1.0	0.7	-1.4	0.4
Hair/balding pattern: Pattern 3	1.1	1.6	3.0	1.6	-0.1	0.8	1.7
Number of live births	1.7	2.4	5.8	-2.4	-0.9	-0.5	-1.6
Forced expiratory volume in 1-second (FEV1)	4.5	15.2	26.3	5.1	5.1	-0.6	2.9
Pulse rate	2.6	4.4	10.0	2.7	-0.0	0.5	3.2
Happiness	0.8	0.9	2.0	0.8	1.4	-1.0	0.1
Noisy workplace	1.4	1.7	4.7	-0.9	-1.0	2.2	-0.7
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.4	0.8	1.6	-0.2	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.8	-0.1	1.4	-0.6	-0.7
Mouth/teeth dental problems: Dentures	1.8	3.0	5.0	2.2	0.8	1.8	1.8
Asthma	1.4	2.7	6.9	-1.9	-0.6	2.6	-0.3
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	3.7	0.8	1.9	0.7	0.4
Medication: Cholesterol lowering	1.5	2.3	7.6	0.1	-2.8	0.3	1.2
Depression (self-reported)	0.3	0.3	0.5	-0.7	-0.5	0.7	-0.2
Medication: Lansoprazole	1.2	1.4	3.4	-0.2	-1.8	1.5	0.1
Prospective memory result	3.2	4.0	6.9	-2.6	-2.1	1.8	-1.1
Lung cancer (father)	1.8	2.1	2.6	-1.5	-1.3	-1.5	-1.6
Illnesses of mother	0.4	0.5	0.9	0.7	0.9	-0.8	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	5.7	18.2	31.2	5.5	5.6	-0.2	3.3
Pulse wave Arterial Stiffness index	1.3	1.5	3.1	1.8	0.0	0.5	1.7
Impedance of arm (left)	0.3	1.3	3.4	1.3	0.5	-0.1	1.8
Arm fat mass (right)	0.1	0.6	0.8	-0.6	-0.8	0.8	-0.9
Trunk predicted mass	1.6	9.3	16.2	3.9	4.0	-1.8	1.7
Standing height	2.3	22.8	39.7	6.3	5.7	-1.9	3.9
Length of working week for main job	0.6	0.7	1.4	-0.4	1.1	-0.2	-1.2
Exposure to tobacco smoke at home	1.3	1.5	3.5	-1.3	-1.9	0.8	-0.5
Breastfed as a baby	0.8	1.0	1.5	-1.2	-0.8	-0.7	-1.1
Tense / ‘highly strung’	1.6	2.7	4.0	-1.8	-2.0	1.3	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.9	-0.4	-0.9	0.2	-0.3
Hair/balding pattern: Pattern 4	0.6	1.6	5.6	0.6	0.6	-2.4	0.2
Birth weight of first child	1.2	2.2	3.8	2.0	1.1	-1.6	1.2
Peak expiratory flow (PEF)	0.4	1.0	3.4	0.6	1.9	0.3	-0.4
Pulse wave reflection index	0.3	0.4	0.9	-0.5	0.4	-0.4	-1.0
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.4	-1.5	1.1	-0.1	-1.2
Loud music exposure frequency	0.5	0.5	1.4	-0.7	0.2	-0.4	-1.2
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.8	1.0	0.7	-1.3	0.5
Mouth/teeth dental problems: Bleeding gums	2.5	3.3	5.5	-2.3	-1.2	2.0	-1.5
Blood clot in the leg (DVT)	0.6	0.8	1.2	-0.5	0.9	-1.1	-1.0
Medication: Paracetamol	0.4	0.6	1.8	-0.2	1.3	0.8	0.0
Headache pain in last month	0.6	1.0	1.7	1.3	1.0	1.0	0.2
Medication for cholesterol, blood pressure or diabetes	2.9	4.8	15.7	1.5	4.0	-0.9	-0.7
Glaucoma (self-reported)	0.7	0.8	1.3	0.9	0.2	1.1	1.1
Gout (self-reported)	0.2	0.3	0.7	-0.3	-0.2	0.9	0.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	-0.2	0.9	0.6	-0.5
Medication: Amlodipine	2.0	2.8	8.2	-1.0	-2.9	1.4	0.4
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	-0.4	-0.5	-0.9	0.4
Birth weight	0.0	0.1	0.2	-0.0	0.5	-0.2	-0.3
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.2	-0.2	-1.1	0.1	-0.1
High blood pressure (siblings)	2.3	3.3	5.3	-2.3	-1.6	1.3	-2.0
Forced vital capacity (FVC), Best measure	10.1	36.9	70.1	8.4	6.2	-1.1	6.1
Body fat percentage	1.2	4.7	6.9	-2.6	-2.4	1.4	-2.0
Leg fat percentage (right)	2.9	10.4	17.1	-4.1	-3.4	1.9	-3.1
Arm fat-free mass (right)	0.8	4.2	8.3	2.6	2.9	-1.1	0.8
Exposure to tobacco smoke outside home	1.3	1.7	2.2	-1.5	-1.4	-1.3	-1.1
Comparative body size at age 10	0.6	1.6	3.4	-0.3	-0.2	1.8	-1.6
Number of full brothers	1.3	1.6	3.4	-1.6	-0.4	-0.2	-1.9
Worry too long after embarrassment	0.4	0.7	1.3	-0.9	0.6	-0.7	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.6	-0.1	-0.9	-1.3	-0.2
Wheeze or whistling in the chest in last year	0.4	0.7	1.1	-0.3	-1.0	1.0	0.8
Number of children fathered	0.3	0.4	1.4	-1.2	-0.2	0.0	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.1	0.0	-1.4	0.3	0.5
Age at first live birth	0.1	0.1	0.2	0.2	-0.3	-0.2	-0.5
Pulse wave peak to peak time	0.7	0.9	1.5	-1.2	0.5	-0.5	-1.2
Health satisfaction	1.2	1.6	3.9	1.4	0.2	0.6	2.0
Shortness of breath walking on level ground	1.7	2.0	3.7	1.8	-1.0	-0.5	1.9
Qualifications: College or University degree	0.5	1.4	2.5	1.1	1.1	-1.6	0.9
Eye problems/disorders: None of the above	0.7	0.8	2.2	-0.1	0.0	-1.5	-1.0
Mouth/teeth dental problems: Loose teeth	1.9	2.2	4.2	-2.0	0.0	1.1	-1.9
Emphysema/chronic bronchitis	1.1	1.3	2.7	-1.3	-1.6	0.7	-0.2
Medication for pain relief, constipation, heartburn	0.9	1.5	1.8	-1.1	-1.1	-1.3	-1.3
Neck or shoulder pain in last month	1.5	2.1	6.2	-1.1	0.4	2.5	-0.9
Medication: Blood pressure	2.8	5.0	13.8	-1.8	-3.7	1.7	-0.3
Angina (self-reported)	1.4	1.8	6.2	0.1	-0.5	2.5	0.8
Migraine (self-reported)	0.6	0.8	1.7	-1.1	0.3	-0.4	-1.3
Medication: Ibuprofen	0.7	0.8	1.5	1.0	1.2	0.7	0.7
Medication: Allopurinol	1.5	2.0	4.0	-2.0	-1.2	0.6	-1.5
Medication: Omeprazole	1.6	2.0	4.1	1.4	-0.3	2.0	1.3
Medication: Seretide 50 evohaler	0.2	0.2	0.6	-0.8	-0.5	-0.3	0.0
Mean time to correctly identify matches	0.3	0.6	2.1	-0.1	-0.4	-1.5	-0.2
Heart disease (mother)	0.1	0.2	0.6	0.0	0.1	0.8	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.5	-1.1	0.8	0.2	-1.2
Whole body fat mass	0.3	1.3	2.0	-1.2	-1.0	1.0	-1.4
Leg fat mass (right)	0.6	2.2	3.1	-1.6	-1.2	1.3	-1.7
Arm predicted mass (right)	1.0	5.0	8.8	3.0	3.0	-1.3	1.0
Pulse rate, automated reading	1.4	4.7	9.7	3.1	-0.7	1.1	2.7
Alcohol intake frequency.	0.9	2.2	6.0	1.0	0.1	2.4	1.3
Comparative height size at age 10	1.7	9.3	17.3	4.2	3.2	0.2	3.1
Number of full sisters	0.5	0.6	1.7	-0.5	0.7	-0.1	-1.3
Suffer from ‘nerves’	0.7	1.1	2.4	-1.6	-1.1	0.4	-0.9
Overall health rating	0.4	0.9	3.1	-0.2	-0.5	1.8	0.6
Chest pain or discomfort	0.7	1.0	2.6	1.1	1.6	-0.1	0.3
Had major operations	0.8	1.0	3.2	0.0	-0.8	-0.0	1.8
Age at last live birth	0.4	0.5	1.1	-0.7	-1.0	-0.2	-0.7
Family relationship satisfaction	0.1	0.1	0.1	-0.4	-0.3	-0.4	0.3
Leg pain on walking	0.2	0.2	0.4	0.5	-0.4	0.2	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	0.9	0.9	0.8	0.9	0.1
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	0.2	0.2	0.7	0.6
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	3.4	-1.8	-1.4	0.7	-1.1
Medication: Aspirin	0.3	0.4	0.8	0.4	-0.8	0.9	0.0
Supplements: Vitamin C	0.8	1.0	1.7	1.0	1.0	-1.3	0.5
Knee pain experienced in last month	1.4	2.1	7.0	0.0	1.2	-0.0	2.6
Hypertension (Self-reported)	1.4	3.8	11.6	-1.1	-3.4	1.3	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.2	0.7	-0.5	1.1	0.3
Illnesses of father: Heart disease	0.3	0.5	1.6	1.3	0.5	-0.1	-0.1
Illnesses of siblings: Diabetes	1.4	1.8	6.8	-0.4	0.2	2.6	0.1
Smoking status: Previous	2.1	3.1	8.5	-1.8	-2.9	-0.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	4.1	8.6	16.5	3.2	4.1	-0.8	2.6
Whole body fat-free mass	1.6	8.9	15.7	4.0	3.7	-1.6	1.8
Leg fat-free mass (right)	1.8	9.9	19.9	4.5	3.6	-1.3	2.2
Arm fat percentage (left)	0.5	2.0	2.7	-1.6	-1.6	0.9	-1.4
Average weekly red wine intake	0.2	0.3	0.3	-0.5	-0.5	-0.6	-0.5
Handedness (chirality/laterality): Left-handed	0.7	0.9	3.1	0.1	0.4	1.8	-0.4
Mood swings	0.5	0.9	2.1	-0.9	-0.4	1.5	-0.8
Loneliness, isolation	0.1	0.2	0.5	0.0	-0.7	-0.5	-0.0
Long-standing illness, disability or infirmity	1.0	1.5	2.5	0.9	0.7	1.6	1.5
Ever had bowel cancer screening	1.7	2.0	4.3	-1.3	-2.1	1.4	-0.5
Diabetes diagnosed by doctor	0.2	0.3	0.7	0.0	-0.6	0.8	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	4.9	2.2	0.8	-1.0	1.1
Friendships satisfaction	0.3	0.3	0.6	0.8	-0.3	0.6	0.5
Qualifications: nursing, teaching	1.4	2.1	4.6	1.2	-2.1	-1.4	0.7
Commuting to job workplace: Walk	1.4	1.5	2.0	-1.4	1.4	0.6	-1.4
Eye problems/disorders: Cataract	0.4	0.4	1.0	0.6	0.6	0.2	1.0
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	2.9	-1.5	-1.7	-0.8	-1.1
Medication for cholesterol	1.1	1.6	4.8	0.1	-0.9	-2.2	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.5	0.7	-0.8	-0.4	1.6
Back pain experienced in last month	2.0	2.9	8.7	-1.3	0.6	2.9	-0.9
Mineral and other dietary supplements	0.3	0.4	1.1	1.1	-0.4	0.0	0.5
Breast cancer (self-reported)	0.4	0.5	0.8	0.5	0.6	0.7	-0.9
Asthma (self-reported)	1.6	3.1	8.3	-1.9	-0.7	2.9	-0.4
Osteoporosis (self-reported)	1.2	1.5	4.6	0.1	-1.0	2.1	0.4
Osteoarthritis (self-reported)	0.6	0.8	2.1	0.6	-0.5	0.7	1.4
Medication: Aspirin	0.6	0.8	2.0	0.3	-1.1	1.4	-0.0
Medication: Gliclazide	0.8	1.0	3.2	-0.8	-1.8	0.1	-0.2
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	-0.1	0.3	-0.7	0.6
Smoking status: Current	0.3	0.4	0.8	0.3	0.8	-0.9	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.4	5.0	12.3	2.4	3.5	0.5	1.3
Whole body water mass	1.5	8.5	15.4	3.9	3.6	-1.6	1.8
Leg predicted mass (right)	1.8	9.6	19.5	4.4	3.5	-1.3	2.2
Arm fat mass (left)	0.1	0.4	0.7	-0.3	-0.4	0.8	-0.8
Number of self-reported non-cancer illnesses	2.1	3.6	11.5	0.1	-0.8	3.4	1.6
Average weekly champagne plus white wine intake	0.9	1.2	2.5	-1.3	0.1	0.8	-1.6
Miserableness	0.4	0.7	1.4	0.8	-0.1	-0.9	1.2
Guilty feelings	0.8	1.2	3.1	-0.4	1.8	-0.4	-1.2
Wears glasses or contact lenses	0.7	0.8	2.2	0.7	-0.7	-1.5	-0.0
Ever taken oral contraceptive pill	1.1	1.2	3.1	0.5	1.8	-1.1	-0.6
Hearing aid user	0.2	0.2	0.4	-0.3	-0.5	0.4	-0.6
Mother’s age at death	1.2	1.5	3.1	-1.5	-0.8	0.4	-1.8
Financial situation satisfaction	0.9	1.1	1.4	-1.2	-0.9	1.2	-0.9
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.6	1.1	1.3	0.2	0.2
Commuting to job workplace: Public transport	0.8	1.0	2.9	0.7	0.5	-1.7	0.7
Eye problems/disorders: Glaucoma	2.0	2.4	5.0	1.9	0.9	0.5	2.2
Medication: Blood pressure	0.6	1.1	3.5	-0.4	-0.3	1.9	0.8
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.4	-0.0	0.4	0.6	0.4
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.3	-1.1	0.0	0.2	-0.6
High cholesterol (Self-reported)	1.1	2.0	6.2	-0.3	-2.5	0.4	1.3
Medication: Bendroflumethiazide	0.9	1.4	2.8	-1.0	-1.7	1.3	0.4
Medication: Paracetamol	0.3	0.5	1.1	-1.1	0.3	0.6	-0.7
Medication: Lisinopril	0.5	0.6	1.8	0.0	-1.4	0.1	0.7
Medication: Atorvastatin	0.9	1.2	2.6	1.0	-0.8	-0.6	1.6
Illnesses of father: High blood pressure	0.5	0.7	1.7	-1.3	-0.1	0.0	-0.9
Alcohol drinker status: Never	0.4	0.5	1.3	0.8	1.1	0.4	0.2
Ever smoked	2.4	4.1	11.2	-1.6	-3.4	-1.4	-0.9
Basal metabolic rate	1.1	6.0	10.9	3.3	3.2	-1.1	1.4
Leg fat percentage (left)	2.6	9.5	15.2	-3.9	-3.3	1.8	-3.0
Arm fat-free mass (left)	0.6	3.2	7.2	2.2	2.7	-0.7	0.5
Number of operations (self-reported)	1.3	1.9	3.6	1.8	0.3	-0.7	1.9
Average weekly beer plus cider intake	0.5	0.7	2.3	0.2	-0.5	0.5	1.5
Irritability	1.3	2.3	5.1	-1.2	-2.3	0.5	-1.5
Risk taking	0.6	0.8	1.8	-0.6	1.1	0.1	-1.3
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.8	-0.8	-0.9	0.5	-0.1
Fractured/broken bones in last 5 years	3.1	4.1	11.4	1.3	3.4	-1.5	0.9
Age started oral contraceptive pill	0.5	0.7	1.6	-0.7	0.1	1.2	-0.8
Diastolic blood pressure, automated reading	2.8	8.7	19.1	3.6	-1.4	0.7	4.4
Ever depressed for a whole week	2.1	2.6	4.8	2.2	1.5	-0.6	1.8
Unable to work because of sickness or disability	1.3	1.7	4.0	2.0	1.0	0.1	1.4
Commuting to job workplace: Cycle	0.6	0.7	1.4	0.7	1.2	-0.9	-0.5
Myopia	1.0	1.4	3.8	0.0	2.0	-0.9	-1.0
Vascular/heart problems diagnosed by doctor	1.1	3.1	9.9	0.7	3.1	-1.1	-0.9
Cholesterol lowering medication	0.6	0.8	2.6	0.4	-0.4	1.6	0.6
Medication: Omeprazole (e.g. Zanprol)	1.0	1.3	4.1	0.8	0.2	2.0	0.6
Pain experienced in last month	1.8	3.0	9.9	0.2	-0.9	-3.1	-1.1
Supplements: Calcium	0.6	0.7	1.2	-0.6	-0.8	0.8	-1.1
Basal cell carcinoma (self-reported)	0.5	0.6	1.8	0.3	1.3	-0.6	0.3
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.1	0.4	-0.8	1.1	0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.5	-0.6	0.8	-1.2	-1.0
Heart disease (siblings)	2.3	2.8	3.9	-2.0	0.5	1.9	-1.9
Alcohol drinker status: Previous	0.5	0.6	2.3	0.2	-0.1	1.5	0.3
Pack years of smoking	0.3	0.4	1.0	-0.6	-0.7	-0.1	-1.0
Impedance of whole body	0.1	0.4	0.8	-0.9	-0.3	0.9	0.1
Leg fat mass (left)	0.6	2.2	3.1	-1.6	-1.3	1.3	-1.7
Arm predicted mass (left)	0.7	3.7	6.9	2.5	2.6	-0.9	0.8