Hub : Genes

SMURF2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.173 0.0560 0.00021 0.129 NA 0.133 NA 0.115 6.6e-10 NA 3.7e-10 NA 6.3e-09
2 GTEx Vagina 0.321 0.1260 0.00920 -0.004 NA 0.064 NA 0.002 4.1e-01 NA 1.4e-02 NA 2.9e-01
3 METSIM Adipose 0.096 0.0337 0.00003 0.009 0.024 0.028 0.016 0.011 1.3e-02 0.00012 3.6e-05 0.0015 6.6e-03
4 TCGA Pancreatic Adenocarcinoma 0.102 0.0590 0.00180 0.006 0.045 -0.003 NA 0.006 1.7e-01 0.00550 4.7e-01 NA 1.7e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.1 0.2 0.4 0.6 0.0 -0.7 0.2
Bipolar Disorder or Schizophrenia 0.1 0.2 0.9 -0.3 0.0 -1.0 -0.1
Depressed Affect (Nagel 2018) 0.1 0.2 0.4 -0.0 -0.6 -0.1 0.7
Depression (Nagel 2018) 0.2 0.3 0.5 -0.7 -0.5 -0.3 -0.5
Intelligence (Savage-Jansen 2018) 0.5 1.6 2.8 1.7 1.6 -1.0 0.3
Neuroticism (Nagel 2018) 0.6 1.4 2.7 -1.4 -1.6 0.9 -0.6
Schizophrenia (2018) 0.1 0.3 0.8 -0.9 0.0 -0.4 -0.3
Schizophrenia vs Biploar Disorder 0.9 1.2 3.3 0.8 0.0 -1.8 0.9
Worry (Nagel 2018) 1.2 2.5 6.6 -1.3 -2.6 1.2 0.3
Alzheimer’s Disease (in mother) 0.6 0.7 1.1 0.8 0.2 -1.0 1.1
Alzheimer’s Disease (in father) 0.5 0.6 1.7 -0.2 -0.7 1.3 -0.3
Alzheimer’s Disease (including proxy) 0.0 0.1 0.1 -0.2 -0.3 0.0 -0.3
Crohns Disease (2017) 0.1 0.3 0.6 -0.7 0.0 0.5 -0.6
Irritable Bowel Disease (IBD) 0.1 0.2 0.4 0.3 0.2 -0.6 0.5
Ulcerative Colitis (UC) 0.3 0.5 1.4 0.3 0.2 -1.2 0.8
Major Depression (MDD) 1.7 2.0 3.6 1.5 0.0 -1.9 1.5
Reaction Time 0.3 0.5 1.2 0.7 0.6 -1.1 0.2
Verbal and Numeric Reasoning (VNR) 1.5 3.5 6.9 2.4 2.6 -1.0 0.7
Breast Cancer 0.7 1.6 2.5 1.4 1.3 -1.6 0.6
Ovarian Cancer 0.2 0.2 0.4 -0.5 0.4 -0.3 -0.7
Prostate Cancer 0.4 0.5 0.8 -0.3 -0.9 -0.9 -0.7
Age at First Birth 0.1 0.2 0.5 0.5 0.0 0.1 -0.7
Bipolar Disorder (2011) 0.1 0.0 0.2 0.4 0.0 0.0 -0.0
Body Mass Index (BMI) (2010) 0.6 0.8 2.5 -1.6 0.0 0.3 -0.7
Coronary Artery Disease (CAD) 0.6 0.7 2.4 1.5 0.0 -0.7 -0.4
Crohns Disease (2012) 0.2 0.3 1.1 0.3 0.0 -1.1 0.3
Mean Putamen Volume 0.4 0.5 1.8 -0.2 0.0 1.3 0.2
Fasting Glucose 0.2 0.3 0.5 -0.7 0.0 0.7 0.2
HbA1C 0.1 0.1 0.2 -0.0 0.0 -0.2 0.5
HDL Cholesterol 1.5 2.5 5.7 -2.1 0.0 -0.2 -2.4
LDL Cholesterol 0.4 0.7 2.4 -0.3 0.0 1.5 0.4
Lupus 0.5 0.8 2.0 -0.5 -1.4 0.7 0.5
Neuroticism (2016) 0.3 0.4 0.7 0.7 0.5 -0.8 0.3
Primary Biliary Cirrhosis 2.3 3.2 4.8 -2.2 -1.2 -1.5 -2.1
Rheumatoid Arthritis 0.0 0.0 0.1 0.2 0.0 -0.0 0.3
Schizophrenia (2014) 0.5 1.1 4.2 -0.2 0.0 -2.1 0.5
Triglycerides 0.9 1.4 3.4 1.3 0.0 -0.7 1.8
Type 2 Diabetes (T2D) (2012) 0.7 0.8 2.0 -1.4 0.0 0.3 1.1
Ulcerative Colitis 0.3 0.5 1.3 0.2 0.0 -0.7 1.2
Blood Eosinophil Count 0.3 2.2 3.2 -1.6 -1.6 1.8 -0.6
Blood Platelet Count 0.1 0.8 2.8 1.7 0.4 -0.2 0.2
Blood Red Count 1.2 11.6 18.3 -4.3 -3.0 1.3 -4.2
Blood White Count 0.3 2.2 5.9 -1.6 -0.6 0.4 -2.4
Heel T-Score 0.8 6.6 11.5 -3.2 -3.4 1.0 1.9
BMI 1.3 7.4 12.4 -3.0 -1.4 2.5 -3.5
Height 2.3 44.2 85.0 9.2 7.8 -3.2 4.6
Waist Hip Ratio (WHR) 0.3 1.3 4.1 0.8 2.0 -0.6 0.2
Systolic Blood Pressure 2.4 12.1 29.8 -3.4 -5.5 2.6 0.3
Smoking Status 0.2 0.6 1.2 -0.5 -1.1 -0.8 -0.3
Allergy or Eczema 0.2 0.5 1.4 0.4 0.8 0.2 1.2
Cardiovascular Disease 1.3 4.3 11.2 -1.5 -3.4 1.8 0.6
Hypothyroidism (self reported) 0.1 0.2 0.4 -0.3 0.4 0.7 -0.5
Respiratory disease 0.8 1.8 4.0 -2.0 -1.0 1.5 -0.1
Type 2 Diabetes (T2D) (2018) 0.0 0.1 0.1 0.1 0.2 0.4 0.3
Lung FEV1/FVC ratio 8.4 42.6 76.2 -8.7 -3.0 3.1 -8.7
Lung FVC 6.4 32.7 71.1 8.4 3.3 -1.0 6.9
Neuroticism 0.5 1.2 2.5 0.2 -1.6 -0.9 1.3
Chronotype (morning person) 0.2 0.5 0.7 -0.2 -0.8 0.9 -0.8
Hair Pigment 0.0 1.0 2.1 -1.3 -0.2 -0.4 -1.4
Tanning 0.1 0.8 2.3 -0.7 -1.5 0.1 0.7
Hand grip strength (left) 0.5 1.2 2.8 0.3 1.7 1.1 -1.0
Number of treatments/medications taken 1.2 2.1 4.6 -1.1 -1.6 2.1 0.1
Average weekly spirits intake 0.4 0.4 0.8 -0.9 -0.7 0.7 -0.1
Sensitivity / hurt feelings 0.3 0.6 1.0 -0.8 -1.0 -0.8 -0.3
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.3 -0.1 -0.1 -0.4 -0.5
Hearing difficulty/problems: Yes 0.8 1.3 2.0 -1.1 -1.4 -1.3 -0.7
Relative age of first facial hair 0.5 0.9 3.0 -0.2 -1.7 0.4 0.7
Other serious medical condition/disability diagnosed by doctor 2.1 2.7 6.5 1.8 0.8 -0.6 2.5
Ever used hormone-replacement therapy (HRT) 0.8 1.1 2.1 -1.4 0.3 0.5 -1.3
Ever had hysterectomy (womb removed) 0.1 0.1 0.3 0.5 -0.0 -0.3 -0.1
Systolic blood pressure, automated reading 2.4 7.1 22.0 -1.4 -4.7 2.0 0.7
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 1.1 0.3 0.1 1.1 -0.0
Angina 1.4 1.9 6.7 0.1 -0.4 2.6 0.9
Medication for hormone replacement therapy 0.4 0.4 1.3 -0.4 0.2 1.1 -0.2
Vitamin and mineral supplements 0.8 1.1 3.9 -0.6 -0.4 2.0 0.0
Supplements: Zinc 0.5 0.5 1.5 -0.4 0.6 0.3 -1.2
Medication: Co-codamol 0.3 0.4 1.3 0.1 -0.4 0.2 1.1
Medication: Metformin 0.4 0.6 1.4 1.2 -0.1 1.0 -0.1
Diabetes (father) 1.9 2.3 4.1 -1.7 -0.7 2.0 -1.3
Diabetes (mother) 0.8 1.1 3.1 -0.7 0.2 1.8 -0.8
Severe depression (siblings) 0.5 0.6 1.2 0.2 1.1 0.7 -0.8
Pack years adult smoking proportion 0.2 0.3 1.0 -0.6 0.1 0.1 -1.0
Impedance of leg (right) 0.9 4.4 10.1 -3.2 -1.5 1.7 -1.6
Leg fat-free mass (left) 1.4 7.3 14.7 3.8 3.2 -0.9 1.8
Trunk fat percentage 0.7 2.9 3.8 -1.9 -2.0 1.4 -1.5
Hand grip strength (right) 0.5 1.3 3.7 0.4 1.9 0.8 -0.9
Townsend deprivation index at recruitment 0.1 0.2 0.3 -0.3 -0.1 0.5 0.5
Current tobacco smoking 0.5 0.8 1.3 0.7 1.1 -1.1 -0.2
Average weekly fortified wine intake 1.5 1.8 2.4 1.5 1.3 -1.5 1.0
Maternal smoking around birth 2.6 3.7 6.5 -2.3 -1.4 -1.2 -2.6
Fed-up feelings 0.3 0.5 1.5 0.1 -1.2 -0.8 0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.1 -1.0 -0.3 -0.7 -0.7
Relative age voice broke 1.0 1.6 2.8 -0.9 -1.7 -1.4 -0.8
Taking other prescription medications 1.1 1.7 4.8 0.5 -0.4 2.2 1.3
Age when periods started (menarche) 0.6 1.5 4.1 -1.2 0.3 -2.0 -0.5
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.3 -0.4 -0.5 0.6 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.7 4.5 0.4 -1.4 -0.4 2.1
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 1.0 1.0 0.5 0.1 1.0
Qualifications: CSEs or equivalent 1.5 1.9 5.2 0.5 2.3 -1.3 0.7
Serious illness, injury or assault to yourself 3.5 4.3 10.5 3.2 1.5 -0.5 2.1
High blood pressure 1.3 3.8 12.4 -1.1 -3.5 1.0 0.7
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.6 -0.3 0.8 0.2 0.6
Multivitamins +/- minerals 0.9 1.1 3.7 0.3 0.3 -1.9 0.7
Stomach or abdominal pain in last month 0.2 0.2 0.5 -0.7 0.2 -0.1 -0.6
Supplements: Glucosamine 0.5 0.6 1.2 -0.3 1.1 -0.9 -0.6
Diverticular disease/diverticulitis (self-reported) 1.7 2.1 3.9 1.6 1.0 -0.8 2.0
Medication: Atenolol 1.3 1.6 2.8 -1.5 -1.3 1.7 0.0
Medication: Levothyroxine sodium 0.3 0.5 0.9 -0.9 0.9 -0.2 -0.5
Sitting height 0.4 2.5 6.5 2.5 1.7 0.1 0.9
Chronic bronchitis/emphysema (father) 0.3 0.3 0.7 0.1 0.6 0.5 0.8
High blood pressure (mother) 0.4 0.6 1.3 -1.1 0.1 0.9 -0.4
Body mass index (BMI) 0.6 2.6 3.1 -1.7 -1.6 1.4 -1.8
Impedance of leg (left) 0.7 3.3 7.9 -2.8 -1.1 1.4 -1.5
Leg predicted mass (left) 1.4 7.3 15.1 3.9 3.1 -1.1 1.9
Trunk fat mass 0.2 0.8 1.2 -0.8 -0.9 0.8 -1.1
Waist circumference 0.1 0.4 1.0 -0.2 -0.4 0.6 -1.0
Number of incorrect matches in round 2.2 3.7 9.2 -1.5 -3.0 1.7 0.6
Past tobacco smoking 2.6 4.8 11.0 2.3 3.3 0.9 1.4
Alcohol usually taken with meals 0.3 0.4 1.0 0.3 0.8 0.1 1.0
Nervous feelings 1.2 2.2 5.4 -1.6 -2.3 1.0 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 2.6 -1.6 -0.1 -0.1 -1.4
Hearing difficulty/problems with background noise 0.7 1.2 4.0 -0.4 -2.0 -0.4 0.7
Hair/balding pattern: Pattern 2 2.1 2.6 5.1 -2.2 0.5 0.6 -2.2
Had menopause 1.4 1.8 3.2 -1.0 0.1 -1.7 -1.8
Had other major operations 0.4 0.5 0.9 1.0 -0.8 -0.2 0.7
Forced vital capacity (FVC) 9.4 36.3 71.6 8.5 6.1 -1.2 5.9
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.8 2.6 0.2 -0.7 -0.3 1.6
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 1.9 1.2 0.1 1.2 1.4
Qualifications: None of the above 1.7 3.6 5.2 -2.3 -1.6 1.3 -2.3
Financial difficulties in last 2 years 0.1 0.2 0.5 0.2 0.2 0.7 -0.5
Mouth/teeth dental problems 0.5 0.8 2.7 -0.3 0.3 -1.7 -0.6
Heart attack 0.3 0.4 1.3 0.3 -0.6 1.1 0.2
Allergy 0.2 0.5 1.0 0.5 -0.4 -1.0 -0.8
Pain all over the body in last month 2.0 2.1 3.8 0.1 -1.9 1.3 1.7
Diabetes (self-reported) 0.3 0.4 1.1 -0.5 -0.0 1.1 -0.6
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 2.8 0.3 0.6 1.7 1.3
Medication: Ramipril 1.6 2.1 6.9 -0.3 -2.6 0.4 1.1
Medication: Simvastatin 1.0 1.4 3.6 -0.5 -1.4 1.9 0.3
Fluid intelligence score 0.5 1.0 1.5 1.2 1.0 -1.2 0.4
Illnesses of siblings 2.0 2.8 5.3 1.8 0.9 -2.3 1.4
Neuroticism score 0.3 0.6 1.8 0.3 -1.3 -0.3 0.8
Weight 0.1 0.6 1.4 1.2 0.9 0.2 0.1
Impedance of arm (right) 0.1 0.5 1.4 0.6 0.1 0.5 1.2
Arm fat percentage (right) 0.6 2.5 3.4 -1.8 -1.8 1.1 -1.5
Trunk fat-free mass 1.6 9.3 16.4 3.9 4.0 -1.8 1.6
Hip circumference 0.1 0.3 0.9 0.2 0.1 0.9 -0.5
Time employed in main current job 2.4 2.7 6.4 -2.1 -0.3 -0.5 -2.5
Alcohol intake versus 10 years previously 0.3 0.4 0.9 1.0 -0.3 0.1 0.9
Father’s age at death 0.6 0.8 1.6 -0.4 1.3 -0.7 -0.9
Worrier / anxious feelings 1.1 2.0 4.2 0.7 -2.0 -0.3 1.8
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.4 4.3 0.2 -1.0 -2.1 0.4
Falls in the last year 0.6 0.9 1.8 1.0 0.7 -1.4 0.4
Hair/balding pattern: Pattern 3 1.1 1.6 3.0 1.6 -0.1 0.8 1.7
Number of live births 1.7 2.4 5.8 -2.4 -0.9 -0.5 -1.6
Forced expiratory volume in 1-second (FEV1) 4.5 15.2 26.3 5.1 5.1 -0.6 2.9
Pulse rate 2.6 4.4 10.0 2.7 -0.0 0.5 3.2
Happiness 0.8 0.9 2.0 0.8 1.4 -1.0 0.1
Noisy workplace 1.4 1.7 4.7 -0.9 -1.0 2.2 -0.7
Qualifications: A levels/AS levels or equivalent 0.4 0.8 2.4 0.8 1.6 -0.2 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.8 -0.1 1.4 -0.6 -0.7
Mouth/teeth dental problems: Dentures 1.8 3.0 5.0 2.2 0.8 1.8 1.8
Asthma 1.4 2.7 6.9 -1.9 -0.6 2.6 -0.3
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 3.7 0.8 1.9 0.7 0.4
Medication: Cholesterol lowering 1.5 2.3 7.6 0.1 -2.8 0.3 1.2
Depression (self-reported) 0.3 0.3 0.5 -0.7 -0.5 0.7 -0.2
Medication: Lansoprazole 1.2 1.4 3.4 -0.2 -1.8 1.5 0.1
Prospective memory result 3.2 4.0 6.9 -2.6 -2.1 1.8 -1.1
Lung cancer (father) 1.8 2.1 2.6 -1.5 -1.3 -1.5 -1.6
Illnesses of mother 0.4 0.5 0.9 0.7 0.9 -0.8 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 5.7 18.2 31.2 5.5 5.6 -0.2 3.3
Pulse wave Arterial Stiffness index 1.3 1.5 3.1 1.8 0.0 0.5 1.7
Impedance of arm (left) 0.3 1.3 3.4 1.3 0.5 -0.1 1.8
Arm fat mass (right) 0.1 0.6 0.8 -0.6 -0.8 0.8 -0.9
Trunk predicted mass 1.6 9.3 16.2 3.9 4.0 -1.8 1.7
Standing height 2.3 22.8 39.7 6.3 5.7 -1.9 3.9
Length of working week for main job 0.6 0.7 1.4 -0.4 1.1 -0.2 -1.2
Exposure to tobacco smoke at home 1.3 1.5 3.5 -1.3 -1.9 0.8 -0.5
Breastfed as a baby 0.8 1.0 1.5 -1.2 -0.8 -0.7 -1.1
Tense / ‘highly strung’ 1.6 2.7 4.0 -1.8 -2.0 1.3 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.9 -0.4 -0.9 0.2 -0.3
Hair/balding pattern: Pattern 4 0.6 1.6 5.6 0.6 0.6 -2.4 0.2
Birth weight of first child 1.2 2.2 3.8 2.0 1.1 -1.6 1.2
Peak expiratory flow (PEF) 0.4 1.0 3.4 0.6 1.9 0.3 -0.4
Pulse wave reflection index 0.3 0.4 0.9 -0.5 0.4 -0.4 -1.0
Ever highly irritable/argumentative for 2 days 1.1 1.3 2.4 -1.5 1.1 -0.1 -1.2
Loud music exposure frequency 0.5 0.5 1.4 -0.7 0.2 -0.4 -1.2
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 1.8 1.0 0.7 -1.3 0.5
Mouth/teeth dental problems: Bleeding gums 2.5 3.3 5.5 -2.3 -1.2 2.0 -1.5
Blood clot in the leg (DVT) 0.6 0.8 1.2 -0.5 0.9 -1.1 -1.0
Medication: Paracetamol 0.4 0.6 1.8 -0.2 1.3 0.8 0.0
Headache pain in last month 0.6 1.0 1.7 1.3 1.0 1.0 0.2
Medication for cholesterol, blood pressure or diabetes 2.9 4.8 15.7 1.5 4.0 -0.9 -0.7
Glaucoma (self-reported) 0.7 0.8 1.3 0.9 0.2 1.1 1.1
Gout (self-reported) 0.2 0.3 0.7 -0.3 -0.2 0.9 0.5
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.8 -0.2 0.9 0.6 -0.5
Medication: Amlodipine 2.0 2.8 8.2 -1.0 -2.9 1.4 0.4
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.9 -0.4 -0.5 -0.9 0.4
Birth weight 0.0 0.1 0.2 -0.0 0.5 -0.2 -0.3
Chronic bronchitis/emphysema (mother) 0.3 0.3 1.2 -0.2 -1.1 0.1 -0.1
High blood pressure (siblings) 2.3 3.3 5.3 -2.3 -1.6 1.3 -2.0
Forced vital capacity (FVC), Best measure 10.1 36.9 70.1 8.4 6.2 -1.1 6.1
Body fat percentage 1.2 4.7 6.9 -2.6 -2.4 1.4 -2.0
Leg fat percentage (right) 2.9 10.4 17.1 -4.1 -3.4 1.9 -3.1
Arm fat-free mass (right) 0.8 4.2 8.3 2.6 2.9 -1.1 0.8
Exposure to tobacco smoke outside home 1.3 1.7 2.2 -1.5 -1.4 -1.3 -1.1
Comparative body size at age 10 0.6 1.6 3.4 -0.3 -0.2 1.8 -1.6
Number of full brothers 1.3 1.6 3.4 -1.6 -0.4 -0.2 -1.9
Worry too long after embarrassment 0.4 0.7 1.3 -0.9 0.6 -0.7 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.6 -0.1 -0.9 -1.3 -0.2
Wheeze or whistling in the chest in last year 0.4 0.7 1.1 -0.3 -1.0 1.0 0.8
Number of children fathered 0.3 0.4 1.4 -1.2 -0.2 0.0 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 2.1 0.0 -1.4 0.3 0.5
Age at first live birth 0.1 0.1 0.2 0.2 -0.3 -0.2 -0.5
Pulse wave peak to peak time 0.7 0.9 1.5 -1.2 0.5 -0.5 -1.2
Health satisfaction 1.2 1.6 3.9 1.4 0.2 0.6 2.0
Shortness of breath walking on level ground 1.7 2.0 3.7 1.8 -1.0 -0.5 1.9
Qualifications: College or University degree 0.5 1.4 2.5 1.1 1.1 -1.6 0.9
Eye problems/disorders: None of the above 0.7 0.8 2.2 -0.1 0.0 -1.5 -1.0
Mouth/teeth dental problems: Loose teeth 1.9 2.2 4.2 -2.0 0.0 1.1 -1.9
Emphysema/chronic bronchitis 1.1 1.3 2.7 -1.3 -1.6 0.7 -0.2
Medication for pain relief, constipation, heartburn 0.9 1.5 1.8 -1.1 -1.1 -1.3 -1.3
Neck or shoulder pain in last month 1.5 2.1 6.2 -1.1 0.4 2.5 -0.9
Medication: Blood pressure 2.8 5.0 13.8 -1.8 -3.7 1.7 -0.3
Angina (self-reported) 1.4 1.8 6.2 0.1 -0.5 2.5 0.8
Migraine (self-reported) 0.6 0.8 1.7 -1.1 0.3 -0.4 -1.3
Medication: Ibuprofen 0.7 0.8 1.5 1.0 1.2 0.7 0.7
Medication: Allopurinol 1.5 2.0 4.0 -2.0 -1.2 0.6 -1.5
Medication: Omeprazole 1.6 2.0 4.1 1.4 -0.3 2.0 1.3
Medication: Seretide 50 evohaler 0.2 0.2 0.6 -0.8 -0.5 -0.3 0.0
Mean time to correctly identify matches 0.3 0.6 2.1 -0.1 -0.4 -1.5 -0.2
Heart disease (mother) 0.1 0.2 0.6 0.0 0.1 0.8 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.5 -1.1 0.8 0.2 -1.2
Whole body fat mass 0.3 1.3 2.0 -1.2 -1.0 1.0 -1.4
Leg fat mass (right) 0.6 2.2 3.1 -1.6 -1.2 1.3 -1.7
Arm predicted mass (right) 1.0 5.0 8.8 3.0 3.0 -1.3 1.0
Pulse rate, automated reading 1.4 4.7 9.7 3.1 -0.7 1.1 2.7
Alcohol intake frequency. 0.9 2.2 6.0 1.0 0.1 2.4 1.3
Comparative height size at age 10 1.7 9.3 17.3 4.2 3.2 0.2 3.1
Number of full sisters 0.5 0.6 1.7 -0.5 0.7 -0.1 -1.3
Suffer from ‘nerves’ 0.7 1.1 2.4 -1.6 -1.1 0.4 -0.9
Overall health rating 0.4 0.9 3.1 -0.2 -0.5 1.8 0.6
Chest pain or discomfort 0.7 1.0 2.6 1.1 1.6 -0.1 0.3
Had major operations 0.8 1.0 3.2 0.0 -0.8 -0.0 1.8
Age at last live birth 0.4 0.5 1.1 -0.7 -1.0 -0.2 -0.7
Family relationship satisfaction 0.1 0.1 0.1 -0.4 -0.3 -0.4 0.3
Leg pain on walking 0.2 0.2 0.4 0.5 -0.4 0.2 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 0.9 0.9 0.8 0.9 0.1
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.4 0.2 0.2 0.7 0.6
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 3.4 -1.8 -1.4 0.7 -1.1
Medication: Aspirin 0.3 0.4 0.8 0.4 -0.8 0.9 0.0
Supplements: Vitamin C 0.8 1.0 1.7 1.0 1.0 -1.3 0.5
Knee pain experienced in last month 1.4 2.1 7.0 0.0 1.2 -0.0 2.6
Hypertension (Self-reported) 1.4 3.8 11.6 -1.1 -3.4 1.3 0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.2 0.7 -0.5 1.1 0.3
Illnesses of father: Heart disease 0.3 0.5 1.6 1.3 0.5 -0.1 -0.1
Illnesses of siblings: Diabetes 1.4 1.8 6.8 -0.4 0.2 2.6 0.1
Smoking status: Previous 2.1 3.1 8.5 -1.8 -2.9 -0.6 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 4.1 8.6 16.5 3.2 4.1 -0.8 2.6
Whole body fat-free mass 1.6 8.9 15.7 4.0 3.7 -1.6 1.8
Leg fat-free mass (right) 1.8 9.9 19.9 4.5 3.6 -1.3 2.2
Arm fat percentage (left) 0.5 2.0 2.7 -1.6 -1.6 0.9 -1.4
Average weekly red wine intake 0.2 0.3 0.3 -0.5 -0.5 -0.6 -0.5
Handedness (chirality/laterality): Left-handed 0.7 0.9 3.1 0.1 0.4 1.8 -0.4
Mood swings 0.5 0.9 2.1 -0.9 -0.4 1.5 -0.8
Loneliness, isolation 0.1 0.2 0.5 0.0 -0.7 -0.5 -0.0
Long-standing illness, disability or infirmity 1.0 1.5 2.5 0.9 0.7 1.6 1.5
Ever had bowel cancer screening 1.7 2.0 4.3 -1.3 -2.1 1.4 -0.5
Diabetes diagnosed by doctor 0.2 0.3 0.7 0.0 -0.6 0.8 -0.0
Ever had stillbirth, spontaneous miscarriage or termination 1.8 1.9 4.9 2.2 0.8 -1.0 1.1
Friendships satisfaction 0.3 0.3 0.6 0.8 -0.3 0.6 0.5
Qualifications: nursing, teaching 1.4 2.1 4.6 1.2 -2.1 -1.4 0.7
Commuting to job workplace: Walk 1.4 1.5 2.0 -1.4 1.4 0.6 -1.4
Eye problems/disorders: Cataract 0.4 0.4 1.0 0.6 0.6 0.2 1.0
Mouth/teeth dental problems: Mouth ulcers 1.1 1.8 2.9 -1.5 -1.7 -0.8 -1.1
Medication for cholesterol 1.1 1.6 4.8 0.1 -0.9 -2.2 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 2.5 0.7 -0.8 -0.4 1.6
Back pain experienced in last month 2.0 2.9 8.7 -1.3 0.6 2.9 -0.9
Mineral and other dietary supplements 0.3 0.4 1.1 1.1 -0.4 0.0 0.5
Breast cancer (self-reported) 0.4 0.5 0.8 0.5 0.6 0.7 -0.9
Asthma (self-reported) 1.6 3.1 8.3 -1.9 -0.7 2.9 -0.4
Osteoporosis (self-reported) 1.2 1.5 4.6 0.1 -1.0 2.1 0.4
Osteoarthritis (self-reported) 0.6 0.8 2.1 0.6 -0.5 0.7 1.4
Medication: Aspirin 0.6 0.8 2.0 0.3 -1.1 1.4 -0.0
Medication: Gliclazide 0.8 1.0 3.2 -0.8 -1.8 0.1 -0.2
Illnesses of father: None of the above (group 1) 0.2 0.2 0.5 -0.1 0.3 -0.7 0.6
Smoking status: Current 0.3 0.4 0.8 0.3 0.8 -0.9 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.4 5.0 12.3 2.4 3.5 0.5 1.3
Whole body water mass 1.5 8.5 15.4 3.9 3.6 -1.6 1.8
Leg predicted mass (right) 1.8 9.6 19.5 4.4 3.5 -1.3 2.2
Arm fat mass (left) 0.1 0.4 0.7 -0.3 -0.4 0.8 -0.8
Number of self-reported non-cancer illnesses 2.1 3.6 11.5 0.1 -0.8 3.4 1.6
Average weekly champagne plus white wine intake 0.9 1.2 2.5 -1.3 0.1 0.8 -1.6
Miserableness 0.4 0.7 1.4 0.8 -0.1 -0.9 1.2
Guilty feelings 0.8 1.2 3.1 -0.4 1.8 -0.4 -1.2
Wears glasses or contact lenses 0.7 0.8 2.2 0.7 -0.7 -1.5 -0.0
Ever taken oral contraceptive pill 1.1 1.2 3.1 0.5 1.8 -1.1 -0.6
Hearing aid user 0.2 0.2 0.4 -0.3 -0.5 0.4 -0.6
Mother’s age at death 1.2 1.5 3.1 -1.5 -0.8 0.4 -1.8
Financial situation satisfaction 0.9 1.1 1.4 -1.2 -0.9 1.2 -0.9
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.6 1.1 1.3 0.2 0.2
Commuting to job workplace: Public transport 0.8 1.0 2.9 0.7 0.5 -1.7 0.7
Eye problems/disorders: Glaucoma 2.0 2.4 5.0 1.9 0.9 0.5 2.2
Medication: Blood pressure 0.6 1.1 3.5 -0.4 -0.3 1.9 0.8
Pain type(s) experienced in last month: Hip pain 0.1 0.2 0.4 -0.0 0.4 0.6 0.4
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.3 -1.1 0.0 0.2 -0.6
High cholesterol (Self-reported) 1.1 2.0 6.2 -0.3 -2.5 0.4 1.3
Medication: Bendroflumethiazide 0.9 1.4 2.8 -1.0 -1.7 1.3 0.4
Medication: Paracetamol 0.3 0.5 1.1 -1.1 0.3 0.6 -0.7
Medication: Lisinopril 0.5 0.6 1.8 0.0 -1.4 0.1 0.7
Medication: Atorvastatin 0.9 1.2 2.6 1.0 -0.8 -0.6 1.6
Illnesses of father: High blood pressure 0.5 0.7 1.7 -1.3 -0.1 0.0 -0.9
Alcohol drinker status: Never 0.4 0.5 1.3 0.8 1.1 0.4 0.2
Ever smoked 2.4 4.1 11.2 -1.6 -3.4 -1.4 -0.9
Basal metabolic rate 1.1 6.0 10.9 3.3 3.2 -1.1 1.4
Leg fat percentage (left) 2.6 9.5 15.2 -3.9 -3.3 1.8 -3.0
Arm fat-free mass (left) 0.6 3.2 7.2 2.2 2.7 -0.7 0.5
Number of operations (self-reported) 1.3 1.9 3.6 1.8 0.3 -0.7 1.9
Average weekly beer plus cider intake 0.5 0.7 2.3 0.2 -0.5 0.5 1.5
Irritability 1.3 2.3 5.1 -1.2 -2.3 0.5 -1.5
Risk taking 0.6 0.8 1.8 -0.6 1.1 0.1 -1.3
Ever had prostate specific antigen (PSA) test 0.4 0.4 0.8 -0.8 -0.9 0.5 -0.1
Fractured/broken bones in last 5 years 3.1 4.1 11.4 1.3 3.4 -1.5 0.9
Age started oral contraceptive pill 0.5 0.7 1.6 -0.7 0.1 1.2 -0.8
Diastolic blood pressure, automated reading 2.8 8.7 19.1 3.6 -1.4 0.7 4.4
Ever depressed for a whole week 2.1 2.6 4.8 2.2 1.5 -0.6 1.8
Unable to work because of sickness or disability 1.3 1.7 4.0 2.0 1.0 0.1 1.4
Commuting to job workplace: Cycle 0.6 0.7 1.4 0.7 1.2 -0.9 -0.5
Myopia 1.0 1.4 3.8 0.0 2.0 -0.9 -1.0
Vascular/heart problems diagnosed by doctor 1.1 3.1 9.9 0.7 3.1 -1.1 -0.9
Cholesterol lowering medication 0.6 0.8 2.6 0.4 -0.4 1.6 0.6
Medication: Omeprazole (e.g. Zanprol) 1.0 1.3 4.1 0.8 0.2 2.0 0.6
Pain experienced in last month 1.8 3.0 9.9 0.2 -0.9 -3.1 -1.1
Supplements: Calcium 0.6 0.7 1.2 -0.6 -0.8 0.8 -1.1
Basal cell carcinoma (self-reported) 0.5 0.6 1.8 0.3 1.3 -0.6 0.3
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.1 0.4 -0.8 1.1 0.2
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 1.5 -0.6 0.8 -1.2 -1.0
Heart disease (siblings) 2.3 2.8 3.9 -2.0 0.5 1.9 -1.9
Alcohol drinker status: Previous 0.5 0.6 2.3 0.2 -0.1 1.5 0.3
Pack years of smoking 0.3 0.4 1.0 -0.6 -0.7 -0.1 -1.0
Impedance of whole body 0.1 0.4 0.8 -0.9 -0.3 0.9 0.1
Leg fat mass (left) 0.6 2.2 3.1 -1.6 -1.3 1.3 -1.7
Arm predicted mass (left) 0.7 3.7 6.9 2.5 2.6 -0.9 0.8