TWAS hub - PLEKHM1P

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2440	0.0410	0.0e+00	0.263	0.191	0.262	0.244	0.270	6.5e-32	1.0e-22	1.0e-31	1.9e-29	8.0e-33
2	TCGA	Breast Invasive Carcinoma	0.0133	0.0136	2.8e-03	0.007	0.005	0.006	NA	0.006	1.0e-02	2.8e-02	1.9e-02	NA	2.1e-02
3	TCGA	Glioblastoma Multiforme	0.0820	0.0710	9.6e-03	0.040	0.038	-0.006	NA	0.027	2.2e-02	2.7e-02	5.6e-01	NA	5.1e-02
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0823	0.0698	6.7e-05	0.033	0.031	0.038	NA	0.032	1.0e-04	1.8e-04	4.0e-05	NA	1.4e-04
5	TCGA	Lung Adenocarcinoma	0.0247	0.0217	4.9e-03	0.015	0.016	0.013	NA	0.012	6.4e-03	4.7e-03	9.6e-03	NA	1.4e-02
6	TCGA	Prostate Adenocarcinoma	0.0190	0.0152	3.9e-03	0.016	0.016	0.013	NA	0.014	7.7e-03	6.7e-03	1.5e-02	NA	1.1e-02
7	TCGA	Thyroid Carcinoma	0.0450	0.0290	2.9e-06	0.033	0.050	0.047	NA	0.039	3.4e-04	1.2e-05	2.0e-05	NA	9.7e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Forced vital capacity (FVC), Best measure	18.1	66.4	79.9	-8.5	-6.5	-8.4	-7.9	-7.9	-8.6	-8.9
Forced vital capacity (FVC)	17.7	68.2	81.9	-8.7	-6.4	-8.5	-7.9	-8.2	-8.8	-9.1
Forced expiratory volume in 1-second (FEV1), Best measure	10.9	34.7	44.2	-6.1	-4.6	-6.0	-6.3	-5.3	-6.0	-6.7
Lung FVC	10.4	52.9	63.5	-7.7	-5.7	-7.7	-6.1	-7.9	-8.0	-7.5
Lung FEV1/FVC ratio	10.1	51.1	64.5	7.6	5.9	7.4	5.2	8.0	8.0	7.4
Forced expiratory volume in 1-second (FEV1)	8.9	29.9	38.4	-5.8	-3.8	-5.6	-5.9	-5.0	-5.6	-6.2
Serious illness, injury or assault to yourself	6.8	8.2	10.4	-2.9	-2.7	-2.9	-2.1	-3.1	-3.2	-3.0
Forced expiratory volume in 1-second (FEV1), predicted	6.5	13.4	21.3	-3.7	-2.7	-3.7	-4.6	-2.9	-3.5	-4.2
Leg fat percentage (right)	4.8	17.5	21.8	4.4	3.2	4.2	3.9	4.1	4.5	4.7
Mouth/teeth dental problems: Bleeding gums	4.7	6.1	7.2	2.7	1.5	2.7	2.4	2.6	2.6	2.5
Leg fat percentage (left)	4.7	17.0	20.7	4.3	3.5	4.2	3.8	4.0	4.4	4.6
Standing height	4.4	43.6	53.9	-6.9	-5.6	-6.7	-6.5	-6.2	-6.9	-7.3
Ever had stillbirth, spontaneous miscarriage or termination	4.4	4.7	5.8	-2.4	-1.3	-2.4	-2.0	-2.4	-2.3	-2.2
Illness, injury, bereavement, stress in last 2 years	4.3	5.3	6.5	2.4	1.5	2.5	2.5	2.2	2.3	2.4
Fractured/broken bones in last 5 years	4.3	5.6	8.1	-2.3	-2.3	-2.2	-2.8	-1.7	-2.3	-2.9
Height	4.1	79.0	97.2	-9.2	-7.7	-9.0	-8.9	-8.2	-9.2	-9.9
Prospective memory result	3.8	4.7	6.0	2.1	2.4	2.0	1.9	2.0	2.3	2.5
Medication: Allopurinol	3.7	5.0	5.8	2.4	1.6	2.4	2.2	2.3	2.3	2.3
Asthma	3.6	7.0	9.3	3.0	1.9	2.9	2.0	3.0	2.9	2.6
Systolic Blood Pressure	3.5	17.3	26.1	4.1	3.8	4.0	5.1	3.0	3.9	4.9
Comparative height size at age 10	3.5	19.4	23.5	-4.7	-3.6	-4.5	-3.8	-4.5	-4.8	-4.8
Leg fat-free mass (right)	3.5	18.7	23.0	-4.6	-3.5	-4.4	-4.2	-4.1	-4.5	-4.8
Leg predicted mass (right)	3.5	18.7	22.8	-4.6	-3.5	-4.4	-4.2	-4.1	-4.5	-4.8
Asthma (self-reported)	3.4	6.8	8.6	2.9	1.9	2.8	2.1	2.9	2.8	2.6
Type 2 Diabetes (T2D) (2012)	3.3	3.8	5.2	2.0	1.4	2.0	2.1	1.7	2.0	2.3
Mouth/teeth dental problems: Dentures	3.3	5.5	6.4	-2.4	-2.0	-2.5	-2.1	-2.5	-2.5	-2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.3	7.1	10.2	-2.6	-2.3	-2.5	-3.1	-2.0	-2.7	-3.2
Medication: Amlodipine	3.2	4.4	6.2	2.1	2.0	2.0	2.5	1.5	2.0	2.5
Illnesses of father: Heart disease	3.2	4.5	5.7	-2.1	-2.3	-2.2	-1.4	-2.4	-2.3	-2.0
Systolic blood pressure, automated reading	3.1	9.0	16.6	2.8	2.7	2.7	4.1	1.8	2.6	3.6
Pulse wave Arterial Stiffness index	3.1	3.6	5.3	-2.1	-1.6	-2.1	-1.2	-2.3	-2.1	-1.8
Respiratory disease	2.9	6.5	7.7	2.7	2.1	2.8	2.4	2.7	2.6	2.5
Trunk fat-free mass	2.9	16.8	20.8	-4.2	-3.9	-4.0	-4.3	-3.5	-4.1	-4.6
Trunk predicted mass	2.9	16.6	20.5	-4.2	-3.9	-4.0	-4.3	-3.5	-4.0	-4.5
Tense / ‘highly strung’	2.9	4.8	7.3	2.3	1.2	2.3	2.7	1.9	2.2	2.4
High blood pressure (siblings)	2.9	4.2	5.2	2.0	1.9	2.0	1.7	2.0	2.3	2.3
Whole body fat-free mass	2.9	16.6	20.4	-4.3	-3.6	-4.1	-4.2	-3.7	-4.1	-4.5
Leg fat-free mass (left)	2.8	14.6	17.7	-4.0	-3.2	-3.9	-3.8	-3.6	-4.0	-4.2
Leg predicted mass (left)	2.8	15.0	17.9	-4.1	-3.3	-3.9	-3.8	-3.7	-4.0	-4.2
Verbal and Numeric Reasoning (VNR)	2.7	6.4	11.3	-2.3	-2.5	-2.5	-3.4	-1.8	-2.3	-2.7
Medication for cholesterol, blood pressure or diabetes	2.7	4.4	9.1	-2.0	-1.7	-1.8	-3.0	-1.1	-1.8	-2.7
Whole body water mass	2.7	15.2	18.8	-4.1	-3.4	-3.9	-4.0	-3.5	-4.0	-4.3
Unable to work because of sickness or disability	2.7	3.5	4.8	-1.8	-2.2	-1.9	-1.4	-1.9	-1.9	-1.9
Medication: Blood pressure	2.6	4.5	8.6	2.1	1.6	1.9	2.9	1.3	1.9	2.7
Primary Biliary Cirrhosis	2.5	3.5	4.5	1.9	2.1	1.8	1.3	1.9	2.0	2.0
Qualifications: O levels/GCSEs or equivalent	2.5	4.0	5.1	-2.1	-1.7	-2.1	-1.5	-2.3	-2.3	-2.0
Heel T-Score	2.4	19.3	23.6	4.7	3.2	4.7	4.9	4.1	4.4	4.7
Body fat percentage	2.4	9.4	11.2	3.2	2.8	3.1	2.8	3.0	3.2	3.3
Qualifications: None of the above	2.3	5.0	5.7	2.3	2.2	2.2	2.0	2.2	2.4	2.4
Cardiovascular Disease	2.2	7.4	13.8	2.7	1.8	2.7	3.7	2.0	2.5	3.1
Past tobacco smoking	2.2	4.0	6.8	-1.9	-1.7	-1.8	-2.6	-1.3	-1.9	-2.5
Alcohol drinker status: Never	2.2	2.6	3.0	-1.7	-1.4	-1.7	-1.5	-1.6	-1.7	-1.7
Current tobacco smoking	2.1	3.5	6.7	-1.6	-2.6	-1.8	-1.8	-1.6	-1.7	-1.8
Maternal smoking around birth	2.1	3.0	3.7	1.9	1.3	1.8	1.7	1.7	1.8	1.9
Mouth/teeth dental problems: Mouth ulcers	2.1	3.3	6.4	1.6	2.5	1.7	1.9	1.4	1.6	1.8
Basal metabolic rate	2.1	11.4	14.1	-3.5	-2.9	-3.4	-3.5	-3.0	-3.4	-3.8
Coronary Artery Disease (CAD)	2.0	2.3	5.4	-1.3	-2.3	-1.4	-1.6	-1.1	-1.3	-1.5
Number of incorrect matches in round	2.0	3.4	6.9	1.9	0.7	1.7	2.6	1.2	1.7	2.3
Pulse rate	2.0	3.3	5.4	-1.9	-1.5	-1.9	-0.9	-2.3	-2.1	-1.7
Mouth/teeth dental problems: Loose teeth	2.0	2.4	3.5	1.6	1.4	1.7	1.0	1.9	1.7	1.4
Hypertension (Self-reported)	2.0	5.5	10.3	2.2	2.0	2.2	3.2	1.5	2.1	2.8
Smoking status: Previous	2.0	3.0	5.2	1.5	1.7	1.5	2.3	1.0	1.6	2.1
Worry (Nagel 2018)	1.9	4.0	7.3	1.9	1.4	2.0	2.7	1.4	1.8	2.3
Medication: Atenolol	1.9	2.3	4.5	1.5	1.0	1.6	2.1	1.2	1.4	1.6
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	3.4	-1.6	-1.3	-1.5	-1.8	-1.2	-1.5	-1.8
HDL Cholesterol	1.8	3.0	3.6	1.7	1.8	1.7	1.9	1.5	1.7	1.9
Worry too long after embarrassment	1.8	3.0	4.8	1.9	1.3	2.0	1.2	2.2	1.9	1.4
Arm predicted mass (right)	1.8	9.1	11.4	-3.2	-2.6	-3.0	-3.2	-2.6	-3.0	-3.4
High blood pressure	1.7	4.7	9.4	2.0	1.7	2.0	3.1	1.3	1.9	2.7
Ever highly irritable/argumentative for 2 days	1.7	2.1	4.6	1.8	-0.0	1.6	0.3	2.2	1.7	1.1
Pulse wave peak to peak time	1.7	2.0	3.3	1.5	1.3	1.5	0.6	1.8	1.6	1.1
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	3.0	-1.3	-1.7	-1.3	-0.8	-1.5	-1.6	-1.5
Impedance of leg (right)	1.6	7.7	9.4	3.1	2.0	2.9	2.3	3.0	3.0	2.9
Average weekly fortified wine intake	1.6	1.9	2.7	-1.5	-1.0	-1.3	-1.0	-1.4	-1.6	-1.6
Sitting height	1.6	11.4	13.5	-3.7	-2.7	-3.6	-2.9	-3.6	-3.6	-3.5
Noisy workplace	1.6	2.0	2.1	1.4	1.3	1.4	1.5	1.3	1.4	1.5
Shortness of breath walking on level ground	1.6	1.9	4.0	-1.5	-0.7	-1.6	-0.4	-2.0	-1.6	-1.1
Supplements: Vitamin C	1.6	1.8	2.2	-1.4	-0.9	-1.4	-1.3	-1.4	-1.5	-1.5
Ever had bowel cancer screening	1.6	1.9	3.6	1.4	0.9	1.3	1.9	0.9	1.2	1.6
Medication: Gliclazide	1.6	1.9	2.6	1.3	1.6	1.2	1.3	1.1	1.4	1.6
Financial situation satisfaction	1.6	2.0	2.3	1.5	1.0	1.5	1.4	1.4	1.5	1.5
High cholesterol (Self-reported)	1.6	2.8	5.6	1.7	0.9	1.6	2.4	1.1	1.5	2.0
Illnesses of father: High blood pressure	1.6	1.9	2.9	1.5	1.3	1.4	0.7	1.7	1.6	1.3
Arm predicted mass (left)	1.6	8.1	10.0	-3.0	-2.3	-2.9	-3.1	-2.5	-2.9	-3.2
Nervous feelings	1.5	2.8	4.6	1.7	1.2	1.6	2.1	1.2	1.6	2.0
Headache pain in last month	1.5	2.6	3.1	-1.7	-0.7	-1.7	-1.7	-1.6	-1.7	-1.7
Number of full brothers	1.5	1.8	2.8	1.3	1.7	1.3	0.8	1.5	1.5	1.3
Health satisfaction	1.5	1.9	2.9	-1.6	-0.1	-1.5	-1.0	-1.7	-1.6	-1.4
Trunk fat percentage	1.4	5.7	6.7	2.4	2.3	2.4	2.3	2.2	2.4	2.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	2.7	1.6	0.5	1.4	0.9	1.6	1.6	1.4
Hair/balding pattern: Pattern 2	1.4	1.8	3.4	1.5	0.7	1.5	0.6	1.8	1.6	1.1
Number of live births	1.4	2.0	2.3	1.5	1.1	1.4	1.2	1.4	1.5	1.5
Arm fat-free mass (right)	1.4	7.4	9.5	-2.8	-2.3	-2.7	-3.0	-2.3	-2.7	-3.1
Chest pain or discomfort	1.4	2.0	2.9	-1.5	-0.8	-1.4	-1.5	-1.3	-1.5	-1.7
Ever taken oral contraceptive pill	1.4	1.6	4.7	-1.1	-0.3	-1.2	-2.2	-0.6	-0.9	-1.4
Tinnitus: Yes, now most or all of the time	1.4	1.7	2.7	-1.4	-0.3	-1.4	-1.6	-1.1	-1.3	-1.5
Diastolic blood pressure, automated reading	1.4	4.2	8.9	-2.2	-1.5	-2.2	-0.3	-3.0	-2.5	-1.6
Impedance of leg (left)	1.3	6.5	7.8	2.8	2.2	2.6	1.9	2.8	2.8	2.6
Birth weight of first child	1.3	2.4	3.3	-1.7	-0.0	-1.7	-1.8	-1.5	-1.6	-1.7
Gout (self-reported)	1.3	1.8	2.6	1.3	1.6	1.4	0.9	1.5	1.4	1.2
Blood Red Count	1.2	11.4	14.7	3.6	2.0	3.5	3.6	3.2	3.5	3.8
Hearing difficulty/problems with background noise	1.2	2.0	3.7	1.4	1.1	1.3	1.9	0.9	1.2	1.6
Arm fat percentage (right)	1.2	4.6	5.7	2.2	1.9	2.1	2.0	2.0	2.3	2.4
Falls in the last year	1.2	1.6	3.0	-1.1	-1.7	-1.2	-0.9	-1.2	-1.3	-1.2
Hair/balding pattern: Pattern 3	1.2	1.8	2.8	-1.6	-0.7	-1.5	-0.8	-1.7	-1.5	-1.2
Medication for pain relief, constipation, heartburn	1.2	2.0	3.0	1.5	0.8	1.5	1.7	1.3	1.4	1.5
Medication: Ibuprofen	1.2	1.4	1.9	-1.3	-0.8	-1.2	-1.3	-1.0	-1.2	-1.4
Mother’s age at death	1.2	1.6	2.1	1.5	0.2	1.3	1.2	1.3	1.4	1.4
Arm fat-free mass (left)	1.2	6.3	8.1	-2.6	-2.1	-2.5	-2.8	-2.1	-2.5	-2.9
Neuroticism (Nagel 2018)	1.1	2.7	3.6	1.7	1.0	1.7	1.8	1.5	1.7	1.9
HbA1C	1.1	1.3	4.7	-0.8	-2.2	-0.9	-1.0	-0.6	-0.7	-0.9
BMI	1.1	6.1	7.5	2.6	1.9	2.6	2.1	2.6	2.7	2.6
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	1.7	-1.2	-0.6	-1.2	-1.3	-1.1	-1.2	-1.3
High blood pressure (mother)	1.1	1.6	2.7	1.5	0.5	1.4	0.7	1.6	1.5	1.2
Arm fat percentage (left)	1.1	4.2	5.1	2.1	1.9	2.1	1.9	2.0	2.2	2.2
Smoking status: Current	1.1	1.8	4.4	-1.0	-2.1	-1.2	-1.2	-1.1	-1.2	-1.2
Number of operations (self-reported)	1.1	1.7	2.0	-1.3	-1.3	-1.4	-1.2	-1.4	-1.3	-1.2
Ever had prostate specific antigen (PSA) test	1.1	1.3	1.7	1.3	0.4	1.2	1.1	1.2	1.3	1.3
Ever depressed for a whole week	1.1	1.4	2.5	-1.3	-0.2	-1.2	-1.6	-0.9	-1.1	-1.4
Vascular/heart problems diagnosed by doctor	1.1	3.0	6.9	-1.7	-1.1	-1.6	-2.6	-0.9	-1.5	-2.2
Major Depression (MDD)	1.0	1.2	1.8	-1.1	-0.8	-1.2	-1.4	-1.0	-1.1	-1.2
Medication: Cholesterol lowering	1.0	1.5	4.0	1.2	0.6	1.0	2.0	0.4	0.9	1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.3	0.8	1.8	0.9	1.0	0.7	0.9	1.2
Emphysema/chronic bronchitis	1.0	1.1	2.3	0.9	1.2	0.9	1.5	0.5	0.8	1.2
Body Mass Index (BMI) (2010)	0.9	1.2	1.6	1.1	1.0	1.0	1.0	1.0	1.2	1.3
Blood Platelet Count	0.9	10.6	12.9	-3.2	-3.3	-3.5	-2.7	-3.6	-3.5	-3.0
Relative age voice broke	0.9	1.4	2.2	1.2	0.8	1.1	1.3	1.0	1.2	1.5
Body mass index (BMI)	0.9	3.6	4.6	2.0	1.6	1.9	1.7	1.9	2.1	2.1
Illnesses of siblings	0.9	1.2	1.7	-1.1	-1.0	-1.0	-0.7	-1.2	-1.3	-1.3
Ever smoked	0.9	1.6	3.5	1.0	1.0	0.9	1.9	0.4	1.1	1.8
Sensitivity / hurt feelings	0.8	1.3	1.8	1.2	0.9	1.1	1.0	1.1	1.3	1.3
Lung cancer (father)	0.8	0.9	1.3	1.0	0.9	0.8	0.9	0.8	1.0	1.2
Suffer from ‘nerves’	0.8	1.2	1.8	1.2	0.6	1.1	1.1	1.1	1.2	1.3
Heart disease (siblings)	0.8	1.0	2.2	1.2	0.3	1.1	0.1	1.5	1.2	0.9
Intelligence (Savage-Jansen 2018)	0.7	2.2	3.9	-1.2	-1.8	-1.4	-2.0	-1.0	-1.2	-1.5
Prostate Cancer	0.7	0.9	1.2	0.9	1.0	0.9	0.9	0.9	1.0	1.1
Fasting Glucose	0.7	0.9	1.5	0.9	0.1	1.0	1.2	0.8	0.9	1.1
Hand grip strength (left)	0.7	1.8	2.7	-1.3	-1.3	-1.3	-1.6	-1.0	-1.2	-1.5
Had other major operations	0.7	0.9	1.5	-1.1	0.3	-1.2	-0.9	-1.2	-0.9	-0.6
Happiness	0.7	0.9	1.3	-0.8	-1.1	-0.8	-1.1	-0.6	-0.9	-1.1
Exposure to tobacco smoke outside home	0.7	0.9	1.4	1.0	0.5	0.9	1.2	0.7	0.9	1.2
Wheeze or whistling in the chest in last year	0.7	1.2	2.0	1.3	0.2	1.2	1.4	0.9	1.0	1.2
Average weekly champagne plus white wine intake	0.7	1.0	1.7	1.1	0.8	1.0	0.2	1.3	1.2	0.9
Eye problems/disorders: Glaucoma	0.7	0.8	1.2	-1.0	-0.2	-0.9	-1.0	-0.9	-1.0	-1.1
Supplements: Fish oil (including cod liver oil)	0.7	1.0	1.3	1.1	0.3	1.1	0.9	1.1	1.0	0.9
Leg fat mass (left)	0.7	2.8	3.4	1.7	1.6	1.6	1.4	1.7	1.8	1.8
Triglycerides	0.6	1.0	1.3	-0.9	-1.0	-1.0	-1.2	-0.8	-1.0	-1.1
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.3	1.0	0.2	1.0	0.6	1.1	1.0	0.7
Medication: Co-codamol	0.6	0.7	1.1	-1.0	-0.2	-1.0	-0.7	-1.1	-0.9	-0.7
Age when periods started (menarche)	0.6	1.5	2.4	1.3	0.8	1.4	0.7	1.6	1.4	1.0
Qualifications: CSEs or equivalent	0.6	0.8	2.2	-0.5	-1.5	-0.5	-1.2	-0.1	-0.5	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.3	1.1	0.6	1.1	0.9	1.1	1.1	0.9
Medication: Simvastatin	0.6	1.0	2.7	1.0	-0.7	0.9	1.6	0.5	0.7	1.1
Fluid intelligence score	0.6	1.2	3.5	-1.0	-0.5	-1.2	-1.9	-0.7	-0.8	-1.1
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.0	-1.1	-1.4	-1.0	-1.0	-0.9	-1.2	-1.4
Medication: Lansoprazole	0.6	0.7	2.1	-0.9	0.4	-0.9	0.2	-1.4	-0.9	-0.2
Breastfed as a baby	0.6	0.8	1.1	0.9	0.7	0.9	0.8	0.9	1.0	1.1
Qualifications: College or University degree	0.6	1.7	2.5	-1.4	-0.6	-1.3	-1.2	-1.4	-1.5	-1.6
Medication: Seretide 50 evohaler	0.6	0.6	0.9	0.8	0.9	0.8	0.7	0.8	0.8	0.8
Leg fat mass (right)	0.6	2.4	3.1	1.6	1.3	1.5	1.3	1.6	1.7	1.7
Pulse rate, automated reading	0.6	1.9	3.8	-1.6	-0.3	-1.5	-0.5	-1.9	-1.6	-1.2
Friendships satisfaction	0.6	0.7	1.4	-1.0	0.1	-0.9	-0.3	-1.2	-1.0	-0.7
Irritability	0.6	1.0	2.1	0.9	0.9	0.8	1.4	0.4	0.8	1.3
Supplements: Calcium	0.6	0.7	1.9	0.6	1.4	0.7	0.6	0.6	0.7	0.8
Depression (Nagel 2018)	0.5	0.7	1.0	1.0	-0.0	0.9	0.7	1.0	0.9	0.9
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.6	1.1	1.1	1.1	0.4	1.3	1.1	0.8
Average weekly spirits intake	0.5	0.7	1.0	0.7	1.0	0.8	1.0	0.6	0.7	0.8
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	0.5	1.1	0.7	1.1	0.4	0.5	0.6
Stomach or abdominal pain in last month	0.5	0.6	1.0	0.9	0.4	0.9	0.6	1.0	0.9	0.7
Pain all over the body in last month	0.5	0.6	2.6	0.4	0.0	0.5	1.6	-0.1	0.3	0.9
Time employed in main current job	0.5	0.6	0.8	0.7	0.9	0.8	0.6	0.8	0.8	0.7
Illnesses of mother	0.5	0.7	1.0	-0.9	-0.6	-0.8	-0.7	-0.8	-0.9	-1.0
Medication: Ventolin 100micrograms inhaler	0.5	0.6	0.9	0.9	0.5	0.8	0.5	0.9	0.9	0.9
Birth weight	0.5	1.0	1.6	-1.2	0.5	-1.1	-1.3	-0.9	-0.9	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.0	0.8	0.8	0.8	1.0	0.6	0.8	0.9
Number of children fathered	0.5	0.6	0.9	0.8	0.6	0.7	0.3	1.0	1.0	0.8
Medication: Omeprazole	0.5	0.6	1.3	-0.8	-0.4	-0.7	0.0	-1.1	-1.0	-0.7
Whole body fat mass	0.5	2.1	2.4	1.5	1.4	1.4	1.2	1.5	1.5	1.5
Qualifications: nursing, teaching	0.5	0.8	2.2	-0.6	-0.7	-0.7	1.0	-1.5	-1.0	-0.1
Illnesses of father: None of the above (group 1)	0.5	0.6	1.7	0.7	1.3	0.8	0.4	0.8	0.7	0.5
Number of treatments/medications taken	0.4	0.6	1.4	0.8	0.7	0.7	1.2	0.3	0.6	1.0
Hand grip strength (right)	0.4	1.1	1.8	-1.0	-0.9	-0.9	-1.3	-0.6	-0.9	-1.3
Allergy	0.4	0.8	1.6	-1.0	-0.6	-1.0	-0.2	-1.3	-1.1	-0.7
Diabetes (self-reported)	0.4	0.6	1.0	0.8	0.9	0.8	0.3	1.0	0.9	0.7
Age at last live birth	0.4	0.6	1.0	0.7	1.0	0.7	0.9	0.5	0.7	0.9
Mood swings	0.4	0.7	0.9	0.9	0.2	0.9	0.7	0.9	1.0	0.9
Diabetes diagnosed by doctor	0.4	0.7	1.0	0.8	1.0	0.8	0.6	0.8	0.9	0.9
Eye problems/disorders: Cataract	0.4	0.5	0.7	-0.6	-0.7	-0.7	-0.5	-0.7	-0.9	-0.8
Medication for cholesterol	0.4	0.6	1.3	-0.9	0.5	-1.0	-0.5	-1.1	-0.9	-0.5
Osteoporosis (self-reported)	0.4	0.5	0.9	0.7	0.6	0.7	0.9	0.5	0.6	0.8
Medication: Bendroflumethiazide	0.4	0.7	1.7	0.8	0.5	0.7	1.3	0.3	0.6	1.0
Risk taking	0.4	0.6	1.1	-0.8	-0.2	-0.7	-1.0	-0.5	-0.7	-0.9
Commuting to job workplace: Cycle	0.4	0.5	1.0	-0.4	-1.0	-0.5	-1.0	-0.2	-0.4	-0.7
Pack years of smoking	0.4	0.6	1.0	0.8	0.5	0.8	1.0	0.7	0.8	0.8
Neuroticism	0.3	0.7	2.0	0.8	-0.2	0.7	1.4	0.4	0.7	1.1
Relative age of first facial hair	0.3	0.5	1.3	0.7	0.3	0.6	0.8	0.5	0.8	1.1
Ever had hysterectomy (womb removed)	0.3	0.3	0.7	-0.5	-0.8	-0.5	-0.3	-0.6	-0.6	-0.5
Medication: Levothyroxine sodium	0.3	0.4	0.9	0.8	0.0	0.9	0.5	0.9	0.6	0.3
Trunk fat mass	0.3	1.2	1.4	1.1	1.1	1.1	1.0	1.1	1.2	1.2
Had menopause	0.3	0.4	0.6	0.7	0.7	0.7	0.4	0.8	0.7	0.5
Financial difficulties in last 2 years	0.3	0.4	1.5	-0.4	-1.2	-0.6	-0.6	-0.4	-0.4	-0.4
Weight	0.3	1.4	1.6	-1.3	-0.9	-1.2	-1.2	-1.1	-1.2	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.4	-0.6	0.3	-0.5	-1.2	-0.1	-0.3	-0.7
Alcohol intake frequency.	0.3	0.8	1.2	-0.8	-1.1	-0.9	-0.7	-0.9	-0.9	-0.8
Number of full sisters	0.3	0.3	0.9	0.4	-0.9	0.1	-0.8	0.6	0.4	0.1
Leg pain on walking	0.3	0.3	2.0	-0.3	1.4	-0.1	0.3	-0.4	-0.3	-0.1
Average weekly red wine intake	0.3	0.4	0.9	0.8	-0.3	0.7	0.9	0.5	0.5	0.7
Number of self-reported non-cancer illnesses	0.3	0.4	1.0	0.6	0.6	0.7	1.0	0.4	0.5	0.7
Medication: Paracetamol	0.3	0.4	0.8	0.6	0.9	0.6	-0.0	0.9	0.7	0.5
Medication: Lisinopril	0.3	0.4	1.3	0.7	-0.3	0.5	1.1	0.2	0.4	0.8
Myopia	0.3	0.5	1.4	0.5	0.6	0.7	-0.4	1.2	0.7	-0.0
Cholesterol lowering medication	0.3	0.4	0.8	0.7	-0.4	0.7	0.9	0.5	0.5	0.6
Schizophrenia (2018)	0.2	0.3	0.6	0.6	-0.2	0.5	0.3	0.6	0.7	0.7
Crohns Disease (2017)	0.2	0.4	0.6	0.6	0.6	0.6	0.3	0.7	0.7	0.5
Breast Cancer	0.2	0.5	1.8	-0.5	-0.4	-0.5	-1.4	-0.1	-0.4	-0.7
Ovarian Cancer	0.2	0.3	0.3	-0.5	-0.6	-0.5	-0.5	-0.5	-0.5	-0.5
LDL Cholesterol	0.2	0.3	0.5	0.5	0.7	0.4	0.2	0.5	0.6	0.6
Blood Eosinophil Count	0.2	1.3	3.2	1.2	0.1	1.1	1.8	0.7	0.9	1.3
Smoking Status	0.2	0.5	1.0	-0.7	-0.7	-0.9	-0.4	-1.0	-0.7	-0.3
Hearing difficulty/problems: Yes	0.2	0.3	0.7	0.6	0.5	0.4	0.8	0.2	0.5	0.8
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	-0.5	-0.1	-0.5	-0.5	-0.4	-0.4	-0.4
Angina	0.2	0.3	0.7	0.5	-0.6	0.5	0.8	0.3	0.3	0.4
Supplements: Zinc	0.2	0.2	0.8	-0.2	-0.9	-0.3	-0.4	-0.2	-0.3	-0.4
Diabetes (father)	0.2	0.3	0.4	0.4	0.6	0.4	0.4	0.4	0.5	0.6
Diabetes (mother)	0.2	0.2	1.0	-0.3	-0.3	-0.5	-1.0	-0.1	-0.1	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.6	0.7	0.2	0.7	1.3	0.3	0.5	0.9
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	-0.6	0.3	-0.4	-0.4	-0.5	-0.6	-0.6
Supplements: Glucosamine	0.2	0.2	0.7	-0.2	-0.8	-0.3	-0.8	0.0	-0.2	-0.5
Mouth/teeth dental problems	0.2	0.2	0.5	0.5	0.4	0.5	0.1	0.7	0.6	0.4
Medication: Ramipril	0.2	0.3	0.9	0.3	0.5	0.0	0.9	-0.3	0.3	1.0
Alcohol intake versus 10 years previously	0.2	0.2	0.4	-0.6	0.3	-0.6	-0.5	-0.6	-0.4	-0.3
Father’s age at death	0.2	0.3	1.0	0.6	-0.0	0.6	-0.3	1.0	0.7	0.2
Worrier / anxious feelings	0.2	0.4	0.8	-0.2	-0.7	-0.4	0.9	-0.9	-0.4	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.8	0.6	-0.4	0.6	0.9	0.4	0.6	0.8
Arm fat mass (right)	0.2	0.8	1.0	0.9	0.9	0.9	0.7	0.9	1.0	1.0
Length of working week for main job	0.2	0.2	0.5	0.3	0.7	0.5	-0.1	0.7	0.5	0.0
Exposure to tobacco smoke at home	0.2	0.3	1.0	0.4	0.0	0.2	1.0	-0.1	0.3	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.6	-0.3	-0.8	-0.4	0.3	-0.7	-0.5	-0.1
Peak expiratory flow (PEF)	0.2	0.4	1.8	-0.4	0.1	-0.3	-1.4	0.3	-0.1	-0.7
Medication: Paracetamol	0.2	0.3	1.5	-0.2	0.1	-0.3	-1.2	0.2	-0.1	-0.5
Angina (self-reported)	0.2	0.3	0.8	0.5	-0.6	0.5	0.9	0.3	0.3	0.5
Mean time to correctly identify matches	0.2	0.4	0.8	0.6	0.5	0.7	0.9	0.4	0.4	0.5
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.6	-0.5	-0.8	-0.5	-0.5	-0.4	-0.5	-0.5
Commuting to job workplace: Walk	0.2	0.2	0.5	0.3	-0.3	0.2	-0.7	0.7	0.4	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	-0.5	0.5	-0.5	-0.2	-0.6	-0.4	-0.1
Mineral and other dietary supplements	0.2	0.3	0.5	-0.7	0.2	-0.7	-0.5	-0.7	-0.6	-0.4
Medication: Blood pressure	0.2	0.3	0.8	0.6	-0.9	0.5	0.5	0.5	0.5	0.5
Average weekly beer plus cider intake	0.2	0.3	0.5	-0.6	0.7	-0.7	-0.7	-0.6	-0.4	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.5	-0.6	-0.3	-0.5	-0.1	-0.7	-0.7	-0.6
Basal cell carcinoma (self-reported)	0.2	0.2	0.7	0.5	-0.2	0.4	-0.6	0.8	0.5	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.4	0.5	-0.6	0.4	0.0	0.6	0.4	0.1
Bipolar Disorder (2018)	0.1	0.2	0.5	-0.5	-0.1	-0.5	-0.7	-0.4	-0.5	-0.5
Schizophrenia vs Biploar Disorder	0.1	0.2	1.2	-1.1	0.0	0.0	0.0	0.0	0.0	0.0
Alzheimer’s Disease (in father)	0.1	0.1	0.3	-0.2	-0.1	-0.2	0.5	-0.5	-0.3	-0.0
Reaction Time	0.1	0.1	0.3	-0.4	-0.2	-0.3	-0.2	-0.3	-0.5	-0.5
Age at First Birth	0.1	0.1	0.3	-0.3	0.6	-0.2	-0.2	-0.3	-0.3	-0.3
Bipolar Disorder (2011)	0.1	0.1	0.7	-0.8	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.1	0.1	0.6	-0.3	0.8	-0.2	-0.4	-0.1	-0.1	-0.3
Neuroticism (2016)	0.1	0.1	0.4	0.2	0.6	0.3	0.1	0.3	0.1	-0.0
Waist Hip Ratio (WHR)	0.1	0.4	1.5	-0.3	0.2	-0.3	-1.2	0.2	-0.3	-0.9
Allergy or Eczema	0.1	0.2	0.8	-0.1	-0.9	-0.1	-0.5	0.1	-0.0	-0.3
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.6	0.0	-0.8	-0.1	0.1	-0.1	-0.1	-0.0
Medication for hormone replacement therapy	0.1	0.1	0.4	0.2	-0.6	0.2	0.1	0.3	0.2	0.1
Vitamin and mineral supplements	0.1	0.1	0.2	0.4	-0.1	0.4	0.4	0.3	0.4	0.4
Medication: Metformin	0.1	0.2	0.3	-0.4	0.5	-0.4	-0.5	-0.4	-0.3	-0.3
Severe depression (siblings)	0.1	0.1	0.5	-0.1	-0.5	-0.1	-0.7	0.3	0.0	-0.3
Pack years adult smoking proportion	0.1	0.2	0.3	0.5	0.2	0.6	0.4	0.6	0.5	0.4
Fed-up feelings	0.1	0.3	0.7	-0.6	-0.1	-0.7	-0.2	-0.8	-0.5	-0.1
Taking other prescription medications	0.1	0.1	0.2	-0.2	-0.4	-0.3	0.2	-0.5	-0.4	-0.1
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.4	0.3	0.3	0.3	-0.3	0.6	0.4	0.1
Multivitamins +/- minerals	0.1	0.2	0.4	0.4	0.7	0.4	0.1	0.5	0.4	0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	0.1	0.4	0.1	-0.4	0.4	0.2	-0.0
Waist circumference	0.1	0.3	0.5	0.6	0.5	0.6	0.3	0.7	0.7	0.7
Alcohol usually taken with meals	0.1	0.2	0.4	0.5	-0.5	0.5	0.1	0.6	0.4	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.5	0.6	0.1	0.5	0.7	0.3	0.4	0.6
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	-0.4	0.5	-0.3	-0.3	-0.2	-0.2	-0.3
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.5	0.4	0.2	0.5	-0.1	0.7	0.5	0.2
Neuroticism score	0.1	0.3	0.9	0.5	-0.2	0.4	0.9	0.1	0.4	0.7
Impedance of arm (left)	0.1	0.6	0.9	-0.8	-0.4	-0.8	-0.5	-0.9	-1.0	-0.9
Hair/balding pattern: Pattern 4	0.1	0.2	0.5	-0.2	-0.7	-0.3	-0.4	-0.2	-0.3	-0.4
Loud music exposure frequency	0.1	0.1	0.2	0.3	0.3	0.2	-0.2	0.4	0.4	0.2
Blood clot in the leg (DVT)	0.1	0.1	0.4	0.2	-0.7	0.2	-0.3	0.4	0.1	-0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.9	-0.0	-1.0	0.0	-0.0	0.0	-0.2	-0.4
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.4	0.1	0.5	0.1	0.6	-0.3	-0.0	0.3
Comparative body size at age 10	0.1	0.2	0.4	-0.4	-0.6	-0.5	-0.3	-0.5	-0.4	-0.3
Age at first live birth	0.1	0.2	0.4	-0.5	0.3	-0.5	-0.1	-0.6	-0.5	-0.3
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.2	-0.0	0.3	0.4	0.3	0.2	0.2
Migraine (self-reported)	0.1	0.1	0.2	0.3	0.1	0.4	0.2	0.4	0.3	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.3	0.3	0.4	0.3	-0.4	0.5	0.3	0.0
Overall health rating	0.1	0.2	0.3	0.4	0.1	0.4	0.5	0.4	0.4	0.5
Had major operations	0.1	0.1	0.3	0.2	0.1	0.1	0.6	-0.1	0.1	0.4
Family relationship satisfaction	0.1	0.1	0.3	0.2	0.6	0.3	0.4	0.2	0.3	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.5	-0.3	-0.1	-0.3	-0.7	0.0	-0.2	-0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.4	0.2	-0.3	-0.2	-0.3	-0.3	-0.3
Medication: Aspirin	0.1	0.1	0.3	-0.1	-0.5	-0.4	-0.1	-0.4	-0.3	0.0
Knee pain experienced in last month	0.1	0.1	0.4	0.3	-0.1	0.4	-0.0	0.6	0.4	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.4	-0.5	-0.1	-0.5	-0.0	-0.6	-0.4	-0.2
Long-standing illness, disability or infirmity	0.1	0.2	0.3	-0.4	-0.2	-0.3	-0.3	-0.4	-0.5	-0.6
Back pain experienced in last month	0.1	0.2	0.4	0.5	0.5	0.5	0.1	0.7	0.5	0.2
Breast cancer (self-reported)	0.1	0.1	0.4	-0.3	-0.6	-0.2	0.1	-0.3	-0.4	-0.5
Osteoarthritis (self-reported)	0.1	0.1	0.3	0.1	-0.6	0.1	0.4	-0.1	0.0	0.2
Arm fat mass (left)	0.1	0.5	0.5	0.7	0.6	0.7	0.5	0.7	0.7	0.7
Miserableness	0.1	0.1	0.2	-0.3	0.4	-0.3	-0.4	-0.3	-0.2	-0.2
Guilty feelings	0.1	0.2	0.7	-0.2	-0.6	-0.1	-0.8	0.3	-0.1	-0.6
Wears glasses or contact lenses	0.1	0.2	0.4	-0.2	-0.6	-0.3	0.2	-0.6	-0.4	-0.1
Hearing aid user	0.1	0.1	0.3	-0.2	0.0	-0.3	-0.5	-0.1	-0.0	0.1
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.3	-0.2	-0.3	-0.5	-0.2	-0.3	-0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.4	0.4	-0.6	0.4	0.3	0.4	0.3	0.1
Medication: Atorvastatin	0.1	0.1	0.3	-0.1	0.5	-0.1	0.3	-0.3	-0.1	0.1
Age started oral contraceptive pill	0.1	0.2	0.3	0.6	-0.1	0.5	0.3	0.5	0.4	0.3
Pain experienced in last month	0.1	0.1	0.3	0.3	0.3	0.2	0.2	0.2	0.4	0.5
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	0.0	0.1	0.0	0.6	-0.3	-0.1	0.2
Alcohol drinker status: Previous	0.1	0.1	0.1	-0.3	0.3	-0.2	0.0	-0.3	-0.3	-0.2
Impedance of whole body	0.1	0.6	0.7	0.8	0.8	0.8	0.6	0.7	0.7	0.7
Bipolar Disorder or Schizophrenia	0.0	0.0	0.1	0.2	-0.2	0.0	-0.2	0.2	0.3	0.3
Depressed Affect (Nagel 2018)	0.0	0.1	0.2	0.3	0.4	0.3	0.3	0.2	0.3	0.4
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	-0.1	0.1	-0.0	0.0	-0.1	-0.1	-0.2
Alzheimer’s Disease (including proxy)	0.0	0.0	0.2	-0.1	-0.1	0.1	0.5	-0.2	-0.1	0.0
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	0.2	0.2	0.2	0.1	0.3	0.2	0.1
Ulcerative Colitis (UC)	0.0	0.1	0.1	0.2	0.2	0.3	0.2	0.3	0.2	0.2
Mean Putamen Volume	0.0	0.0	0.0	0.2	-0.1	0.0	0.2	-0.1	-0.1	0.0
Lupus	0.0	0.1	0.1	0.0	0.0	-0.2	0.3	-0.3	-0.0	0.4
Rheumatoid Arthritis	0.0	0.0	0.0	-0.1	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2014)	0.0	0.1	0.2	0.2	-0.4	0.0	-0.1	0.2	0.2	0.2
Ulcerative Colitis	0.0	0.1	0.4	0.7	0.0	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.0	0.0	0.1	0.3	-0.1	0.0	0.1	0.0	0.1	0.3
Hypothyroidism (self reported)	0.0	0.1	0.2	0.3	0.0	0.4	0.4	0.3	0.2	0.1
Chronotype (morning person)	0.0	0.0	0.1	0.0	0.4	-0.0	0.1	-0.0	0.2	0.3
Hair Pigment	0.0	1.0	1.9	0.9	1.0	1.1	1.4	0.8	0.8	0.8
Tanning	0.0	0.1	0.5	0.3	-0.0	0.1	0.4	-0.0	0.3	0.7
Townsend deprivation index at recruitment	0.0	0.1	0.1	-0.2	-0.3	-0.3	-0.1	-0.4	-0.3	-0.2
Heart attack	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.3	-0.3	-0.2	0.0
Impedance of arm (right)	0.0	0.1	0.2	-0.3	-0.2	-0.3	-0.1	-0.4	-0.4	-0.4
Hip circumference	0.0	0.1	0.1	-0.3	-0.2	-0.3	-0.4	-0.2	-0.2	-0.2
Depression (self-reported)	0.0	0.0	0.1	0.2	-0.0	0.2	0.2	0.1	0.2	0.3
Pulse wave reflection index	0.0	0.0	0.2	-0.1	0.0	-0.1	-0.4	0.1	0.0	-0.2
Glaucoma (self-reported)	0.0	0.0	0.2	0.0	0.4	0.0	-0.1	0.1	0.0	-0.0
Neck or shoulder pain in last month	0.0	0.0	0.1	-0.0	-0.3	-0.0	-0.2	0.1	-0.0	-0.1
Heart disease (mother)	0.0	0.1	0.2	0.3	-0.1	0.3	0.4	0.2	0.1	0.1
Illnesses of siblings: Diabetes	0.0	0.0	0.1	0.1	-0.1	0.0	-0.3	0.3	0.2	0.1
Loneliness, isolation	0.0	0.1	0.2	0.3	0.1	0.2	0.3	0.1	0.2	0.4
Medication: Aspirin	0.0	0.0	0.1	0.0	-0.1	-0.2	0.1	-0.3	-0.1	0.3

Hub : Genes

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Models

Trait associations