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chr19:45,187,302-47,796,800

Best TWAS P=2.02e-11 · Best GWAS P=3.05e-09 conditioned to 0.0768

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	EML2	0.06	0.03	lasso	6	0.03	4.3e-05	-4.8	5.4	8.0e-08	0.05	0.01	0.98	TRUE
2	CommonMind	Brain Pre-frontal Cortex	PNMAL1	0.14	0.12	enet	31	0.12	1.2e-14	-5.1	-5.8	8.8e-09	-0.31	0.16	0.84	FALSE
3	CommonMind	Brain Pre-frontal Cortex	PNMAL2	0.08	0.06	enet	20	0.07	5.0e-09	-4.8	5.3	9.6e-08	0.16	0.46	0.53	FALSE
4	GTEx	Adrenal Gland	PNMAL1	0.65	0.63	lasso	2	0.64	1.2e-29	-5.1	-5.4	7.5e-08	-0.15	0.08	0.91	FALSE
5	GTEx	Artery Aorta	PNMAL1	0.43	0.42	lasso	3	0.42	1.2e-24	-5.0	-5.1	2.9e-07	-0.14	0.09	0.90	FALSE
6	GTEx	Artery Coronary	PNMAL1	0.34	0.32	lasso	5	0.35	1.9e-12	-5.1	-5.2	1.8e-07	-0.14	0.09	0.91	FALSE
7	GTEx	Artery Tibial	PNMAL1	0.42	0.38	enet	19	0.39	3.6e-32	-5.0	-5.1	3.1e-07	-0.14	0.09	0.90	FALSE
8	GTEx	Breast Mammary Tissue	PNMAL1	0.34	0.23	lasso	6	0.22	7.8e-12	-5.1	-5.3	1.5e-07	-0.12	0.09	0.91	FALSE
9	GTEx	Cells Transformed fibroblasts	CCDC8	0.22	0.10	lasso	6	0.19	6.2e-14	-5.1	-5.4	7.9e-08	-0.14	0.09	0.91	FALSE
10	GTEx	Cells Transformed fibroblasts	PNMAL1	0.62	0.62	enet	23	0.62	1.1e-58	-5.0	-5.4	6.2e-08	-0.15	0.09	0.90	TRUE
11	GTEx	Esophagus Muscularis	CALM3	0.26	0.09	lasso	10	0.13	1.7e-08	-3.3	-5.4	7.5e-08	-0.74	0.02	0.98	FALSE
12	GTEx	Nerve Tibial	PNMAL1	0.63	0.58	lasso	5	0.64	1.4e-57	-5.0	-5.3	1.1e-07	-0.12	0.09	0.90	FALSE
13	GTEx	Pancreas	PNMAL1	0.55	0.47	lasso	4	0.50	1.0e-23	-5.1	-5.2	2.1e-07	-0.13	0.09	0.91	FALSE
14	GTEx	Testis	CALM3	0.52	0.46	lasso	5	0.45	5.6e-22	5.8	-5.8	6.4e-09	-0.96	0.00	1.00	FALSE
15	GTEx	Testis	CTB-12A17.3	0.43	0.31	lasso	5	0.33	3.0e-15	5.7	-5.6	1.8e-08	-0.95	0.00	1.00	FALSE
16	METSIM	Adipose	PNMAL1	0.24	0.27	bslmm	380	0.28	2.9e-41	-5.0	-5.2	2.0e-07	-0.18	0.18	0.82	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	CALM3	0.08	0.04	blup	49	0.05	4.8e-10	5.9	-6.7	2.0e-11	-0.87	0.00	1.00	TRUE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	PNMAL1	0.18	0.30	lasso	4	0.30	8.7e-63	-5.0	-5.2	2.4e-07	-0.15	0.00	0.99	FALSE
19	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PNMAL1	0.23	0.20	lasso	4	0.20	2.1e-10	-5.1	-5.2	1.6e-07	-0.13	0.00	0.99	FALSE
20	The Cancer Genome Atlas	Colon Adenocarcinoma	PNMAL1	0.28	0.33	lasso	3	0.35	4.1e-21	-5.0	-5.2	2.2e-07	-0.14	0.00	0.99	FALSE
21	The Cancer Genome Atlas	Esophageal Carcinoma	PNMAL1	0.22	0.25	lasso	4	0.22	9.7e-08	-5.1	-5.1	2.7e-07	-0.13	0.00	0.99	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PNMAL1	0.31	0.41	lasso	6	0.41	7.6e-50	-5.0	-5.2	2.5e-07	-0.14	0.00	0.99	FALSE
23	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PNMAL1	0.11	0.14	lasso	6	0.15	7.1e-09	-5.0	-5.2	1.6e-07	-0.13	0.00	0.99	FALSE
24	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	APOC1P1	0.11	0.02	blup	38	0.04	7.6e-03	-3.9	-5.1	2.7e-07	0.03	0.00	0.05	TRUE
25	The Cancer Genome Atlas	Lung Adenocarcinoma	PNMAL1	0.26	0.32	lasso	6	0.33	8.0e-40	-5.1	-5.2	1.9e-07	-0.13	0.00	0.99	FALSE
26	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PNMAL1	0.25	0.30	lasso	4	0.30	1.5e-34	-5.0	-5.1	2.7e-07	-0.14	0.00	0.99	FALSE
27	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PNMAL1	0.07	0.05	enet	10	0.06	5.3e-05	-5.0	-5.2	1.8e-07	-0.11	0.00	0.99	FALSE
28	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PNMAL1	0.39	0.38	lasso	6	0.39	1.4e-17	-5.0	-5.2	1.6e-07	-0.14	0.00	0.99	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	PNMAL1	0.43	0.54	enet	9	0.54	3.3e-67	-5.0	-5.1	2.9e-07	-0.14	0.00	0.99	FALSE
30	The Cancer Genome Atlas	Rectum Adenocarcinoma	PNMAL1	0.37	0.32	lasso	4	0.21	9.4e-06	-5.0	-5.1	3.1e-07	-0.13	0.00	0.99	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	SNRPD2	0.04	0.03	enet	7	0.03	2.6e-04	-4.0	5.2	1.7e-07	0.03	0.02	0.83	FALSE