Hub : Genes

PNMAL2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0780	0.0270	5.7e-04	0.063	0.042	0.071	0.058	0.059	3.8e-08	6.9e-06	5.1e-09	1.3e-07	1.1e-07
2	TCGA	Breast Invasive Carcinoma	0.0173	0.0076	1.7e-04	0.006	0.017	0.013	NA	0.008	1.8e-02	1.5e-04	7.7e-04	NA	5.9e-03
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0417	0.0212	2.2e-03	0.013	0.008	0.009	NA	0.006	1.1e-02	3.5e-02	2.7e-02	NA	6.1e-02
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0573	0.0228	2.7e-06	0.023	0.046	0.048	NA	0.034	1.2e-03	6.3e-06	4.0e-06	NA	9.7e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	2.4	3.8	4.9	-1.8	2.1	2.2	1.7
Bipolar Disorder or Schizophrenia	1.1	2.7	4.0	-1.5	2.0	1.7	1.3
Depressed Affect (Nagel 2018)	0.0	0.1	0.2	-0.5	0.2	-0.0	-0.0
Depression (Nagel 2018)	0.5	0.7	1.5	-1.2	-0.1	-0.8	-0.7
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.4	1.2	-0.2	-0.2	-0.1
Neuroticism (Nagel 2018)	0.1	0.3	0.6	-0.0	-0.3	-0.8	-0.8
Schizophrenia (2018)	0.2	0.3	0.8	-0.5	0.9	0.3	0.4
Schizophrenia vs Biploar Disorder	1.4	1.9	2.6	1.2	-1.6	-1.5	-1.1
Worry (Nagel 2018)	0.3	0.7	2.0	0.3	-0.3	-0.8	-1.4
Alzheimer’s Disease (in mother)	0.6	0.7	1.7	-0.3	0.4	0.8	1.3
Alzheimer’s Disease (in father)	0.3	0.3	0.5	0.2	-0.7	0.5	-0.7
Alzheimer’s Disease (including proxy)	0.1	0.2	0.5	-0.2	0.1	0.5	0.7
Crohns Disease (2017)	0.5	1.0	2.2	0.4	-1.1	-0.7	-1.5
Irritable Bowel Disease (IBD)	0.2	0.4	1.2	0.2	-0.4	-1.1	-0.4
Ulcerative Colitis (UC)	0.2	0.4	0.8	-0.4	0.5	-0.5	0.9
Major Depression (MDD)	0.0	0.0	0.0	0.2	-0.2	-0.2	-0.1
Reaction Time	1.9	3.6	5.7	-1.7	2.0	1.4	2.4
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.6	0.8	0.5	-0.2	0.3
Breast Cancer	0.3	0.6	1.7	-0.1	0.9	0.2	1.3
Ovarian Cancer	0.1	0.1	0.3	0.2	-0.5	-0.3	-0.4
Prostate Cancer	0.2	0.3	0.6	0.3	-0.1	-0.8	-0.7
Age at First Birth	0.2	0.2	0.8	0.2	0.3	0.9	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	1.3	-0.1	0.9	1.1	1.1
Coronary Artery Disease (CAD)	0.0	0.0	0.0	-0.1	0.0	0.0	0.0
Crohns Disease (2012)	0.3	0.5	0.9	0.9	-0.5	-0.4	-0.9
Mean Putamen Volume	0.1	0.1	0.2	0.0	-0.5	-0.2	0.0
Fasting Glucose	0.2	0.3	1.0	-0.2	-0.2	1.0	-0.1
HbA1C	1.1	1.2	1.8	1.3	-1.1	-0.9	-0.9
HDL Cholesterol	1.6	2.6	3.8	1.4	-1.9	-1.8	-1.2
LDL Cholesterol	0.2	0.3	0.5	0.3	0.7	-0.5	0.7
Lupus	0.1	0.2	0.4	-0.4	-0.1	0.6	0.4
Neuroticism (2016)	0.1	0.1	0.2	-0.3	0.2	-0.5	-0.2
Primary Biliary Cirrhosis	1.3	1.8	2.3	1.5	-0.7	-1.5	-1.5
Rheumatoid Arthritis	1.1	1.5	2.0	1.1	-1.3	-1.0	-1.4
Schizophrenia (2014)	0.5	1.1	1.4	-1.0	1.2	1.1	1.0
Triglycerides	0.1	0.2	0.3	0.6	0.2	0.4	0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.3	0.4	-0.2	-0.6	-0.4
Ulcerative Colitis	0.0	0.1	0.1	-0.2	0.3	-0.3	-0.2
Blood Eosinophil Count	0.8	6.4	7.5	2.4	-2.7	-2.6	-2.5
Blood Platelet Count	0.2	2.8	3.2	1.5	-1.7	-1.7	-1.8
Blood Red Count	0.2	1.6	4.4	0.5	-2.1	-0.2	-1.3
Blood White Count	0.0	0.2	0.3	0.5	-0.3	-0.5	-0.6
Heel T-Score	0.2	1.2	4.5	0.4	-2.1	0.2	-0.4
BMI	2.2	12.9	14.7	-3.2	3.5	3.8	3.8
Height	1.1	20.9	38.2	-6.2	5.1	3.6	2.5
Waist Hip Ratio (WHR)	0.6	2.8	5.9	1.4	-1.4	-2.4	-1.3
Systolic Blood Pressure	0.1	0.3	0.5	0.6	-0.3	-0.7	-0.5
Smoking Status	0.1	0.2	0.2	0.4	-0.4	-0.4	0.3
Allergy or Eczema	1.0	2.7	4.3	1.6	-1.3	-2.1	-1.5
Cardiovascular Disease	0.2	0.6	1.2	-1.1	0.7	0.5	0.6
Hypothyroidism (self reported)	0.1	0.3	1.1	0.2	0.1	-1.0	-0.2
Respiratory disease	0.7	1.5	2.3	1.3	-1.3	-0.1	-1.5
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.3	-0.9	0.7	-0.1	1.1
Lung FEV1/FVC ratio	3.5	17.9	24.2	-3.6	4.9	3.8	4.5
Lung FVC	4.5	22.7	28.5	5.3	-4.4	-4.8	-4.4
Neuroticism	0.1	0.2	0.7	-0.5	0.8	-0.0	0.2
Chronotype (morning person)	10.0	23.2	26.7	5.1	-4.7	-4.2	-5.2
Hair Pigment	0.0	0.1	0.2	0.4	-0.1	0.4	-0.1
Tanning	0.1	0.9	1.6	-1.2	0.5	1.0	0.9
Hand grip strength (left)	1.1	2.9	4.8	-1.7	1.2	2.2	1.6
Number of treatments/medications taken	0.7	1.2	1.5	1.2	-1.1	-1.2	-0.9
Average weekly spirits intake	0.2	0.2	0.4	-0.2	0.6	0.5	0.4
Sensitivity / hurt feelings	0.4	0.6	1.8	-0.1	-0.4	-1.3	-0.7
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.9	0.1	-0.2	-0.9	-0.6
Hearing difficulty/problems: Yes	0.0	0.1	0.2	-0.3	-0.4	0.1	-0.1
Relative age of first facial hair	0.3	0.5	0.9	-0.9	1.0	-0.3	0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.7	-0.4	0.9	0.6	0.1
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	0.2	-0.8	-0.5	-0.5
Ever had hysterectomy (womb removed)	0.4	0.5	1.7	-0.4	-0.1	-1.3	-0.0
Systolic blood pressure, automated reading	0.4	1.0	1.5	0.9	-1.2	-0.8	-1.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.9	-0.5	0.7	0.2	0.9
Angina	1.6	2.0	2.4	-1.4	1.3	1.6	1.4
Medication for hormone replacement therapy	0.5	0.6	0.8	0.7	-0.8	-0.6	-0.9
Vitamin and mineral supplements	0.1	0.2	0.3	0.1	0.4	0.5	0.5
Supplements: Zinc	0.1	0.2	0.3	0.1	0.4	-0.3	0.6
Medication: Co-codamol	0.7	0.8	1.3	-1.0	1.1	0.3	0.9
Medication: Metformin	0.6	0.9	1.7	-1.3	0.7	0.5	1.1
Diabetes (father)	0.9	1.1	1.6	-0.5	1.3	1.3	1.1
Diabetes (mother)	0.4	0.4	1.2	-1.1	-0.2	0.1	0.8
Severe depression (siblings)	3.8	4.3	8.4	0.9	-2.3	-1.7	-2.9
Pack years adult smoking proportion	0.0	0.1	0.2	-0.1	-0.0	0.4	0.3
Impedance of leg (right)	1.7	8.1	12.6	3.5	-2.1	-3.3	-2.1
Leg fat-free mass (left)	3.3	17.3	21.9	-4.7	4.2	4.2	3.4
Trunk fat percentage	0.2	0.9	1.6	0.1	1.3	0.6	1.3
Hand grip strength (right)	1.1	2.9	4.0	-2.0	1.3	1.9	1.5
Townsend deprivation index at recruitment	0.1	0.2	0.4	0.6	-0.5	-0.4	-0.2
Current tobacco smoking	0.7	1.1	2.4	-1.5	0.5	0.7	1.1
Average weekly fortified wine intake	0.1	0.2	0.4	-0.5	-0.6	-0.1	-0.2
Maternal smoking around birth	0.6	0.9	1.4	0.6	-1.1	-0.7	-1.2
Fed-up feelings	0.1	0.1	0.4	-0.3	0.3	0.1	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.9	-0.7	-0.4	-0.9	-0.5
Relative age voice broke	0.8	1.2	2.9	-0.9	1.7	0.6	0.9
Taking other prescription medications	1.5	2.4	3.7	1.3	-1.6	-1.3	-1.9
Age when periods started (menarche)	1.2	2.9	5.9	-1.8	2.4	1.3	0.9
Bilateral oophorectomy (both ovaries removed)	1.3	1.6	2.3	-1.4	1.4	0.1	1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	-0.0	-0.5	-0.1	-0.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.6	-0.6	-0.7	-0.8	-0.8
Qualifications: CSEs or equivalent	0.5	0.6	1.3	-0.8	0.5	0.6	1.1
Serious illness, injury or assault to yourself	0.2	0.2	0.4	0.2	0.1	-0.5	0.7
High blood pressure	0.3	0.7	1.1	0.8	-1.0	-0.6	-0.9
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.7	0.9	-0.8	-1.6	-0.5
Multivitamins +/- minerals	0.2	0.2	0.4	-0.3	-0.6	-0.0	-0.6
Stomach or abdominal pain in last month	0.4	0.5	1.2	0.7	-0.4	-1.1	-0.5
Supplements: Glucosamine	0.9	1.1	1.5	1.0	-0.7	-1.2	-1.2
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	2.2	1.3	-1.2	-0.7	-1.5
Medication: Atenolol	0.4	0.5	1.0	1.0	-0.8	0.3	-0.6
Medication: Levothyroxine sodium	0.6	1.0	1.8	-1.3	1.3	0.0	0.8
Sitting height	0.3	2.2	3.2	-1.8	1.6	1.4	1.1
Chronic bronchitis/emphysema (father)	0.2	0.3	0.8	0.9	0.2	-0.5	0.0
High blood pressure (mother)	0.3	0.4	1.5	0.1	-0.3	0.2	1.2
Body mass index (BMI)	1.2	5.1	7.3	-1.9	2.0	2.7	2.3
Impedance of leg (left)	2.0	9.7	14.7	3.8	-2.5	-3.5	-2.4
Leg predicted mass (left)	3.2	17.2	21.6	-4.7	4.2	4.2	3.4
Trunk fat mass	0.9	3.7	5.3	-1.3	2.3	1.7	2.2
Waist circumference	0.7	2.5	3.1	-1.5	1.5	1.8	1.5
Number of incorrect matches in round	0.1	0.1	0.1	-0.3	-0.3	-0.3	0.3
Past tobacco smoking	0.8	1.4	2.0	-1.4	1.1	1.4	0.6
Alcohol usually taken with meals	0.6	0.9	2.2	-1.2	-0.2	1.5	-0.2
Nervous feelings	1.4	2.6	3.7	1.1	-1.5	-1.8	-1.9
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.8	0.3	-0.4	-0.8	-0.9
Hearing difficulty/problems with background noise	0.5	0.9	2.3	-1.5	-0.0	0.9	0.6
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.2
Had menopause	0.2	0.3	0.9	-0.3	-0.9	-0.5	-0.2
Had other major operations	0.3	0.4	1.0	0.2	-0.6	-0.5	-1.0
Forced vital capacity (FVC)	1.5	5.6	8.4	2.9	-1.7	-2.7	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	-0.0	-0.6	-0.4	-0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	-0.4	-0.4	0.1	0.2
Qualifications: None of the above	0.1	0.3	0.7	-0.9	-0.2	0.5	-0.4
Financial difficulties in last 2 years	1.7	2.4	5.4	0.7	-2.3	-0.9	-1.6
Mouth/teeth dental problems	0.2	0.3	0.7	0.2	0.8	-0.4	0.3
Heart attack	1.0	1.3	3.1	-1.8	0.7	1.1	0.6
Allergy	0.2	0.4	0.9	-0.5	0.9	0.5	0.6
Pain all over the body in last month	0.4	0.5	1.3	-0.1	0.4	-1.1	0.6
Diabetes (self-reported)	0.8	1.2	2.2	-1.2	1.0	0.4	1.5
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.5	-0.7	-0.2	0.4	0.2
Medication: Ramipril	0.3	0.4	0.5	-0.5	0.5	0.7	0.7
Medication: Simvastatin	0.0	0.1	0.1	0.2	-0.1	0.3	0.2
Fluid intelligence score	0.2	0.5	0.9	0.5	0.9	-0.4	0.8
Illnesses of siblings	2.1	3.0	3.8	-1.3	1.8	1.8	1.9
Neuroticism score	0.1	0.2	0.5	-0.0	-0.3	-0.7	-0.4
Weight	2.3	11.2	12.3	-3.4	3.5	3.5	3.0
Impedance of arm (right)	1.7	7.7	11.3	3.4	-1.9	-3.3	-2.3
Arm fat percentage (right)	0.6	2.2	3.9	-0.6	1.6	1.4	2.0
Trunk fat-free mass	2.8	16.1	20.3	-4.5	3.9	4.3	3.3
Hip circumference	1.7	7.1	8.4	-2.6	2.9	2.8	2.4
Time employed in main current job	0.0	0.0	0.1	0.1	0.0	0.2	-0.2
Alcohol intake versus 10 years previously	4.1	6.1	9.2	-3.0	1.8	2.8	2.0
Father’s age at death	0.3	0.5	1.2	0.2	0.1	1.1	0.7
Worrier / anxious feelings	0.2	0.3	0.8	0.1	-0.3	-0.9	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.2	0.5	0.1	0.3
Falls in the last year	2.6	3.5	4.1	-1.9	1.5	1.9	2.0
Hair/balding pattern: Pattern 3	0.4	0.6	1.2	-0.7	1.1	0.6	0.6
Number of live births	0.1	0.2	0.3	0.6	-0.2	-0.5	-0.2
Forced expiratory volume in 1-second (FEV1)	1.3	4.4	8.0	2.8	-1.5	-2.3	-1.4
Pulse rate	1.9	3.2	5.3	1.1	-2.0	-2.3	-1.5
Happiness	0.4	0.5	1.4	-1.2	0.7	-0.2	0.3
Noisy workplace	0.5	0.6	1.3	0.5	-0.9	0.2	-1.1
Qualifications: A levels/AS levels or equivalent	0.4	0.8	2.2	0.3	1.0	0.2	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.5	-0.1	-0.7	0.3	0.6
Mouth/teeth dental problems: Dentures	1.0	1.7	3.5	-1.9	0.4	1.5	1.1
Asthma	0.2	0.5	0.6	0.7	-0.8	0.2	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.0	-0.7	1.0	0.6	0.9
Medication: Cholesterol lowering	0.0	0.0	0.1	0.1	0.2	-0.1	0.3
Depression (self-reported)	3.2	3.8	5.0	1.0	-2.2	-2.1	-2.2
Medication: Lansoprazole	1.2	1.3	3.2	1.8	-0.7	-0.9	-0.9
Prospective memory result	0.3	0.3	0.9	-1.0	-0.4	-0.5	-0.3
Lung cancer (father)	2.1	2.5	3.6	1.7	-1.9	-1.3	-1.3
Illnesses of mother	1.3	1.7	3.2	1.4	-0.9	-0.8	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.6	5.7	2.4	-1.7	-2.0	-1.3
Pulse wave Arterial Stiffness index	0.3	0.4	0.5	-0.4	0.6	0.7	0.7
Impedance of arm (left)	2.0	9.1	15.1	3.4	-2.0	-3.9	-2.4
Arm fat mass (right)	1.4	5.7	6.7	-1.9	2.5	2.5	2.6
Trunk predicted mass	2.7	15.4	19.4	-4.4	3.8	4.2	3.2
Standing height	0.9	8.5	13.1	-3.6	3.6	2.1	1.9
Length of working week for main job	0.3	0.3	1.0	-0.4	-0.1	1.0	0.1
Exposure to tobacco smoke at home	0.5	0.6	1.2	0.6	-0.8	-1.1	-0.3
Breastfed as a baby	3.4	4.3	7.1	1.6	-2.1	-2.7	-1.7
Tense / ‘highly strung’	0.8	1.4	2.9	0.6	-0.9	-1.2	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.7	5.5	1.2	-2.3	-2.3	-1.6
Hair/balding pattern: Pattern 4	0.3	0.7	1.1	0.7	-1.1	-0.2	-1.1
Birth weight of first child	0.3	0.5	0.9	-0.4	-0.8	-0.6	-1.0
Peak expiratory flow (PEF)	1.4	3.3	7.4	2.7	-1.9	-1.5	-0.4
Pulse wave reflection index	2.1	2.6	5.6	-0.5	1.6	2.4	1.4
Ever highly irritable/argumentative for 2 days	2.5	2.9	4.9	-2.0	1.1	2.2	1.3
Loud music exposure frequency	3.1	3.4	4.9	-1.3	1.6	2.2	2.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.4	0.7	0.8	-0.4	1.2
Mouth/teeth dental problems: Bleeding gums	5.1	6.6	7.4	2.7	-2.7	-2.4	-2.5
Blood clot in the leg (DVT)	0.2	0.2	0.7	-0.2	-0.4	0.9	-0.2
Medication: Paracetamol	0.5	0.9	1.3	-1.2	1.1	0.5	0.8
Headache pain in last month	0.3	0.6	2.1	-1.4	0.4	0.2	0.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.8	-0.7	0.2	0.9	0.2
Glaucoma (self-reported)	0.2	0.2	0.7	-0.5	0.9	-0.1	0.1
Gout (self-reported)	2.3	3.2	5.8	-0.7	1.5	2.0	2.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.1	-1.0	0.8	0.1	0.6
Medication: Amlodipine	0.3	0.5	1.1	1.1	0.3	-0.8	0.2
Medication: Ventolin 100micrograms inhaler	0.8	1.1	2.0	0.6	-1.3	1.4	-0.2
Birth weight	1.1	2.3	3.5	-1.9	1.4	0.8	1.8
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.6	0.6	0.1	-0.2
High blood pressure (siblings)	1.0	1.4	2.7	0.9	-0.8	-1.6	-1.2
Forced vital capacity (FVC), Best measure	1.2	4.3	5.6	2.4	-1.8	-2.3	-1.7
Body fat percentage	0.3	1.2	2.3	-0.1	1.4	0.7	1.5
Leg fat percentage (right)	0.4	1.5	2.5	-0.3	1.4	1.2	1.6
Arm fat-free mass (right)	2.5	13.0	16.5	-4.1	3.5	3.8	3.0
Exposure to tobacco smoke outside home	1.4	1.8	1.9	-1.4	1.4	1.3	1.4
Comparative body size at age 10	0.1	0.3	0.9	0.1	-0.1	0.9	0.6
Number of full brothers	0.2	0.2	0.5	-0.7	-0.3	-0.2	0.5
Worry too long after embarrassment	0.3	0.6	0.9	0.0	-1.0	-0.7	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	6.4	8.4	14.9	2.0	-2.3	-3.9	-3.0
Wheeze or whistling in the chest in last year	0.0	0.1	0.2	-0.4	-0.2	0.2	-0.2
Number of children fathered	0.7	0.8	1.7	-0.4	0.4	1.0	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.8	0.9	-0.2	-0.5	-0.3
Age at first live birth	0.3	0.5	0.9	0.9	-0.8	-0.5	-0.6
Pulse wave peak to peak time	0.2	0.2	0.4	0.2	-0.4	-0.6	-0.6
Health satisfaction	2.0	2.6	3.4	-1.9	1.6	1.1	1.8
Shortness of breath walking on level ground	0.2	0.2	0.6	-0.2	-0.4	0.1	-0.8
Qualifications: College or University degree	0.0	0.1	0.2	0.5	-0.5	-0.3	-0.0
Eye problems/disorders: None of the above	0.2	0.2	0.6	0.4	-0.1	-0.8	-0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.4	-0.6	-0.6	0.4	-0.4
Emphysema/chronic bronchitis	0.1	0.2	0.4	-0.4	-0.6	-0.2	-0.2
Medication for pain relief, constipation, heartburn	1.0	1.7	2.1	1.4	-1.4	-1.1	-1.3
Neck or shoulder pain in last month	0.7	1.0	1.8	1.3	-1.0	-1.2	-0.2
Medication: Blood pressure	0.2	0.3	0.6	0.8	-0.3	-0.8	-0.2
Angina (self-reported)	1.6	2.0	2.4	-1.6	1.2	1.5	1.4
Migraine (self-reported)	1.3	1.6	1.9	-1.3	1.1	1.4	1.3
Medication: Ibuprofen	0.3	0.3	0.4	-0.6	0.6	0.6	0.5
Medication: Allopurinol	0.8	1.1	1.8	-0.6	0.8	1.3	1.3
Medication: Omeprazole	0.0	0.0	0.1	-0.2	-0.2	0.3	-0.0
Medication: Seretide 50 evohaler	1.7	2.0	2.8	1.1	-1.5	-1.2	-1.7
Mean time to correctly identify matches	1.3	2.5	3.0	-1.7	1.5	1.4	1.7
Heart disease (mother)	0.1	0.2	0.6	-0.8	-0.1	-0.1	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.2	1.1	-1.1	-0.6	-0.8
Whole body fat mass	1.1	4.6	5.8	-1.6	2.4	2.0	2.4
Leg fat mass (right)	1.8	6.8	7.9	-2.1	2.8	2.7	2.8
Arm predicted mass (right)	2.6	13.1	16.7	-4.1	3.5	3.8	3.0
Pulse rate, automated reading	0.2	0.7	1.9	-1.4	-0.3	-0.8	-0.1
Alcohol intake frequency.	2.1	4.9	8.9	-3.0	2.1	1.8	1.7
Comparative height size at age 10	0.2	1.1	3.2	-1.8	0.9	0.4	0.5
Number of full sisters	3.8	4.7	7.1	1.6	-2.2	-2.0	-2.7
Suffer from ‘nerves’	0.5	0.8	1.3	1.0	-0.5	-1.1	-0.7
Overall health rating	0.3	0.6	1.6	-1.3	0.6	0.2	0.7
Chest pain or discomfort	0.4	0.5	1.4	-0.8	-0.3	1.2	0.0
Had major operations	0.4	0.4	0.8	0.9	-0.8	-0.2	-0.4
Age at last live birth	3.8	5.5	9.3	3.0	-2.5	-1.9	-1.7
Family relationship satisfaction	1.3	1.6	2.6	-1.6	0.9	1.6	0.6
Leg pain on walking	0.7	0.8	1.8	0.2	-0.7	-1.0	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	2.9	-0.9	1.7	0.5	1.7
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.3	0.4	-0.1	0.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.8	0.5	1.3	0.1	-0.1
Medication: Aspirin	0.3	0.4	0.7	-0.8	-0.6	0.8	-0.0
Supplements: Vitamin C	0.1	0.1	0.4	0.3	0.0	-0.6	-0.2
Knee pain experienced in last month	0.1	0.1	0.2	0.2	-0.5	-0.2	-0.4
Hypertension (Self-reported)	0.4	1.1	1.6	0.9	-1.2	-0.7	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.7	1.3	-0.1	-0.2	0.4
Illnesses of father: Heart disease	4.0	5.5	7.8	-1.9	2.8	2.0	2.5
Illnesses of siblings: Diabetes	1.8	2.2	3.9	0.9	-1.6	-2.0	-1.3
Smoking status: Previous	0.6	0.9	1.6	1.2	-0.8	-1.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.8	2.8	-1.1	1.7	0.9	1.4
Whole body fat-free mass	3.0	17.3	21.5	-4.6	4.1	4.4	3.4
Leg fat-free mass (right)	3.0	15.9	20.4	-4.5	4.0	4.1	3.2
Arm fat percentage (left)	0.5	1.9	3.6	-0.5	1.6	1.1	1.9
Average weekly red wine intake	0.3	0.4	0.7	0.8	-0.9	-0.2	-0.4
Handedness (chirality/laterality): Left-handed	6.1	7.3	8.4	-2.6	2.7	2.9	2.6
Mood swings	0.5	0.8	1.2	1.1	-0.8	-0.8	-0.9
Loneliness, isolation	0.7	1.0	1.7	-1.3	0.7	1.3	0.5
Long-standing illness, disability or infirmity	0.9	1.4	3.0	1.7	-0.7	-1.5	-0.3
Ever had bowel cancer screening	3.3	3.8	4.5	1.7	-2.1	-2.1	-1.9
Diabetes diagnosed by doctor	1.3	2.2	4.1	-1.6	1.4	0.5	2.0
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	0.8	-0.7	-0.5	0.0
Friendships satisfaction	0.2	0.3	0.4	0.0	-0.6	0.6	0.6
Qualifications: nursing, teaching	0.8	1.2	2.3	0.0	1.5	1.0	1.3
Commuting to job workplace: Walk	0.5	0.5	1.4	0.5	-0.6	-0.4	-1.2
Eye problems/disorders: Cataract	0.7	0.8	1.8	1.3	-0.6	-0.7	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.8	-0.0	-0.3	0.9	-0.4
Medication for cholesterol	0.1	0.2	0.5	-0.7	0.5	-0.1	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	0.3	0.4	-0.5	0.6
Back pain experienced in last month	0.3	0.4	1.1	-1.1	0.2	0.7	0.4
Mineral and other dietary supplements	0.1	0.2	0.7	0.0	-0.2	0.9	0.1
Breast cancer (self-reported)	1.4	1.7	3.1	-1.8	1.2	1.3	0.8
Asthma (self-reported)	0.3	0.6	0.9	0.9	-0.9	0.2	-0.9
Osteoporosis (self-reported)	0.4	0.5	1.2	-0.1	0.5	0.7	1.1
Osteoarthritis (self-reported)	0.4	0.5	1.0	1.0	-0.3	-0.8	-0.2
Medication: Aspirin	0.4	0.5	1.5	-0.2	-1.2	0.5	-0.6
Medication: Gliclazide	2.1	2.4	5.1	-0.8	1.8	0.6	2.3
Illnesses of father: None of the above (group 1)	4.4	5.4	7.2	2.3	-2.7	-1.9	-2.3
Smoking status: Current	0.6	1.0	2.1	-1.5	0.5	0.7	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	6.2	2.5	-1.5	-1.5	-1.1
Whole body water mass	3.0	16.9	21.3	-4.6	4.0	4.3	3.4
Leg predicted mass (right)	3.0	16.1	20.6	-4.5	4.0	4.2	3.2
Arm fat mass (left)	1.4	5.5	6.9	-1.8	2.6	2.4	2.5
Number of self-reported non-cancer illnesses	0.4	0.8	1.2	1.1	-1.0	-0.5	-0.8
Average weekly champagne plus white wine intake	0.1	0.1	0.2	0.5	0.1	0.2	-0.4
Miserableness	0.1	0.1	0.2	-0.4	0.2	0.2	0.4
Guilty feelings	1.6	2.4	2.9	1.3	-1.7	-1.5	-1.6
Wears glasses or contact lenses	0.6	0.7	1.6	-0.8	1.3	-0.3	0.7
Ever taken oral contraceptive pill	1.5	1.7	2.7	-0.5	1.6	1.1	1.6
Hearing aid user	3.3	3.8	7.6	-2.8	1.4	1.2	2.0
Mother’s age at death	0.9	1.1	2.0	1.0	-1.4	-1.1	-0.6
Financial situation satisfaction	0.1	0.1	0.4	-0.0	-0.2	-0.7	0.2
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.5	0.1	0.3	-0.7	-0.1
Commuting to job workplace: Public transport	0.7	0.8	1.9	0.5	-0.7	-0.9	-1.4
Eye problems/disorders: Glaucoma	0.3	0.3	0.7	-0.9	0.8	-0.2	0.1
Medication: Blood pressure	0.0	0.1	0.3	0.6	0.0	0.0	-0.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.0	0.7	-1.0	-0.7	-0.8
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	-0.4	0.2	-0.4	0.4
High cholesterol (Self-reported)	0.2	0.3	0.6	0.8	-0.6	0.2	0.3
Medication: Bendroflumethiazide	0.3	0.4	0.7	0.7	-0.3	-0.5	-0.8
Medication: Paracetamol	0.1	0.2	0.3	-0.3	-0.4	-0.4	-0.5
Medication: Lisinopril	1.7	2.2	2.7	-1.1	1.4	1.6	1.6
Medication: Atorvastatin	0.2	0.2	0.4	-0.6	0.5	0.3	0.4
Illnesses of father: High blood pressure	0.7	0.8	1.5	0.1	-0.9	-1.0	-1.2
Alcohol drinker status: Never	2.4	2.9	4.6	-1.7	2.2	1.4	1.4
Ever smoked	0.2	0.4	0.6	0.8	-0.8	-0.5	0.0
Basal metabolic rate	3.2	17.5	20.7	-4.5	4.2	4.4	3.5
Leg fat percentage (left)	0.3	1.1	1.8	-0.2	1.1	1.2	1.3
Arm fat-free mass (left)	2.8	14.0	17.1	-4.1	3.6	4.1	3.1
Number of operations (self-reported)	0.1	0.1	0.2	-0.4	-0.1	-0.0	0.4
Average weekly beer plus cider intake	0.2	0.2	0.6	0.8	-0.5	-0.2	-0.4
Irritability	0.2	0.3	0.5	-0.7	0.5	-0.0	0.7
Risk taking	1.5	2.1	3.6	-1.2	1.2	1.9	1.5
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	0.3	-0.1	-0.1	0.4
Fractured/broken bones in last 5 years	2.8	3.6	4.2	-2.0	2.0	1.7	1.8
Age started oral contraceptive pill	1.3	1.6	3.7	1.1	-1.2	-0.1	-1.9
Diastolic blood pressure, automated reading	0.4	1.1	2.1	0.6	-1.4	-0.9	-1.1
Ever depressed for a whole week	0.5	0.6	1.3	-0.9	0.5	0.5	1.1
Unable to work because of sickness or disability	0.8	1.0	1.4	-1.0	1.2	1.1	0.7
Commuting to job workplace: Cycle	0.0	0.0	0.1	0.1	0.3	-0.2	0.0
Myopia	0.4	0.5	1.0	-0.5	1.0	0.7	0.6
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.4	-1.1	1.6	0.8	1.1
Cholesterol lowering medication	0.4	0.6	1.2	1.1	-1.0	-0.1	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.4	-0.3	0.2	0.6	0.1
Pain experienced in last month	0.6	1.0	2.1	1.5	-0.6	-0.5	-1.1
Supplements: Calcium	0.1	0.1	0.2	-0.1	0.5	0.3	0.3
Basal cell carcinoma (self-reported)	0.8	1.0	1.6	0.6	-1.3	-0.8	-1.1
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.1	-1.5	0.5	0.9	0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.5	-0.1	-0.7	0.6	-0.6
Heart disease (siblings)	1.0	1.2	2.0	1.2	-1.2	-0.1	-1.4
Alcohol drinker status: Previous	0.6	0.7	1.0	-1.0	1.0	0.7	0.4
Pack years of smoking	0.0	0.0	0.0	-0.0	-0.2	0.1	0.0
Impedance of whole body	2.3	11.7	16.3	4.0	-2.6	-4.0	-2.7
Leg fat mass (left)	1.6	6.2	7.0	-2.0	2.6	2.6	2.6
Arm predicted mass (left)	2.7	13.7	16.3	-4.0	3.5	4.0	3.1