TWAS hub - APOC1P1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Clear Cell Carcinoma	0.0519	0.0230	1.9e-04	0.029	0.026	0.013	NA	0.016	2.7e-04	5.2e-04	1.1e-02	NA	6.2e-03
2	TCGA	Brain Lower Grade Glioma	0.1735	0.0551	1.2e-10	0.044	0.075	0.088	NA	0.084	9.1e-06	7.6e-09	3.2e-10	NA	9.4e-10
3	TCGA	Liver Hepatocellular Carcinoma	0.1070	0.0460	2.0e-03	0.022	0.037	0.021	NA	0.016	3.1e-02	7.5e-03	3.4e-02	NA	5.8e-02
4	TCGA	Lung Adenocarcinoma	0.0276	0.0149	8.5e-03	-0.001	0.011	0.011	NA	0.004	4.7e-01	1.5e-02	1.6e-02	NA	1.0e-01
5	TCGA	Testicular Germ Cell Tumors	0.1410	0.0690	5.2e-03	0.009	0.059	0.027	NA	0.029	1.5e-01	3.8e-03	3.8e-02	NA	3.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Alzheimer’s Disease (including proxy)	174.8	253.4	800.9	28.3	6.2	-4.3	6.0	19.3
Alzheimer’s Disease (in mother)	71.2	83.4	265.7	16.3	3.4	-4.2	2.7	10.7
Alzheimer’s Disease (in father)	27.1	29.4	94.9	9.7	2.0	-1.8	1.1	6.6
Average weekly fortified wine intake	13.2	15.5	28.4	-5.3	-3.7	-2.3	-4.1	-3.7
Loud music exposure frequency	6.9	7.5	15.2	3.9	2.7	1.2	2.9	2.3
High cholesterol (Self-reported)	6.9	12.2	38.2	4.5	-0.5	-6.2	-0.4	-1.4
Illnesses of father: None of the above (group 1)	5.2	6.5	11.0	-3.3	-2.4	-2.0	-0.8	-3.3
Hand grip strength (left)	4.6	12.0	14.8	-3.7	-2.8	-3.9	-3.1	-3.8
Hand grip strength (right)	4.4	12.1	15.3	-3.5	-2.8	-3.6	-3.4	-3.9
Mouth/teeth dental problems: Mouth ulcers	4.0	6.3	9.5	2.3	2.8	3.1	1.1	2.8
Illnesses of mother	3.6	4.4	15.1	-3.9	-0.9	0.1	-1.6	-1.8
Blood White Count	3.5	25.6	42.8	5.6	5.1	3.6	6.5	3.9
Back pain experienced in last month	3.5	5.1	9.2	-2.9	-3.0	-1.1	-0.5	-2.5
Relative age of first facial hair	3.3	6.7	11.0	-3.3	-2.2	-1.9	-3.1	-2.2
Wears glasses or contact lenses	3.3	3.8	8.4	2.7	1.2	0.4	2.9	1.2
Forced expiratory volume in 1-second (FEV1)	3.1	10.3	20.3	-2.5	-3.1	-4.5	-3.1	-2.4
Tinnitus: Yes, now most or all of the time	3.0	3.5	6.5	-2.5	-2.4	0.1	-2.1	-0.9
Weight	2.9	14.3	33.4	-5.8	-4.3	0.6	-4.1	-1.5
Birth weight	2.9	6.3	11.8	-3.0	-3.4	-2.2	-2.2	-0.7
Bipolar Disorder (2018)	2.8	4.5	8.8	-0.4	-2.4	-3.0	1.1	-2.6
Alcohol usually taken with meals	2.8	4.5	6.6	1.9	2.6	2.5	1.4	2.0
Cholesterol lowering medication	2.8	4.1	11.0	3.3	1.3	-2.8	-0.1	0.3
Arm predicted mass (left)	2.8	14.1	30.1	-5.5	-4.3	0.0	-4.3	-1.7
Forced vital capacity (FVC)	2.7	10.5	21.4	-2.3	-3.1	-4.6	-3.0	-2.6
Trunk fat-free mass	2.7	15.5	30.5	-5.5	-4.5	-0.4	-4.9	-1.5
Supplements: Vitamin C	2.7	3.2	5.7	-1.7	-1.3	-2.3	-0.7	-2.4
Arm fat-free mass (left)	2.7	13.9	29.4	-5.4	-4.4	-0.2	-4.2	-1.7
Trunk predicted mass	2.6	14.9	29.7	-5.5	-4.4	-0.4	-4.8	-1.5
Medication: Atorvastatin	2.6	3.2	9.3	2.5	0.2	-3.0	-0.0	0.3
Basal metabolic rate	2.6	14.6	31.4	-5.6	-4.4	0.2	-4.5	-1.4
Eye problems/disorders: Diabetes related eye disease	2.4	2.7	5.0	-1.9	-2.2	-0.9	-1.1	-1.7
High blood pressure (siblings)	2.4	3.5	10.6	-0.7	2.0	3.3	-1.5	0.2
Whole body fat-free mass	2.4	13.8	28.7	-5.4	-4.2	0.0	-4.5	-1.3
Whole body water mass	2.4	13.6	28.2	-5.3	-4.2	0.0	-4.5	-1.4
Lung FVC	2.3	11.8	26.5	-2.2	-2.7	-5.1	-2.5	-3.8
Medication: Cholesterol lowering	2.3	3.5	10.4	2.6	-0.2	-3.2	-0.8	-0.3
Pulse wave Arterial Stiffness index	2.3	2.7	6.5	-1.0	-2.5	-1.6	0.7	-1.7
Exposure to tobacco smoke at home	2.3	2.5	7.6	-0.7	-2.8	-1.5	-0.0	-1.6
Arm fat-free mass (right)	2.3	11.6	24.7	-5.0	-4.0	0.1	-3.8	-1.6
Alcohol intake frequency.	2.3	5.3	14.6	-1.1	-3.8	-3.0	-0.8	-1.0
BMI	2.2	12.8	33.1	-5.8	-3.7	0.8	-3.1	-2.6
Fluid intelligence score	2.2	4.7	8.9	1.4	2.4	2.4	0.8	3.0
Worrier / anxious feelings	2.2	4.2	10.3	3.2	0.8	-0.6	2.6	1.7
Number of full brothers	2.2	2.8	7.3	1.3	1.4	2.7	0.7	1.6
Health satisfaction	2.2	2.8	6.2	0.3	-1.3	-2.5	1.5	-2.0
Medication: Omeprazole	2.2	2.7	5.2	-2.1	-1.8	-0.6	-2.3	-0.4
Ever had bowel cancer screening	2.2	2.6	4.9	-2.2	-1.7	-0.6	-1.9	-1.2
Leg fat mass (left)	2.2	8.8	22.5	-4.7	-3.5	0.7	-2.5	-1.5
Ever used hormone-replacement therapy (HRT)	2.1	2.6	5.0	-1.2	-2.2	-1.8	0.3	-1.8
Alcohol intake versus 10 years previously	2.1	3.1	10.6	1.1	-1.4	-3.3	0.5	-1.1
Leg fat mass (right)	2.1	8.3	20.8	-4.6	-3.5	0.7	-2.4	-1.5
Hearing aid user	2.1	2.4	3.5	-1.0	-1.6	-1.9	-1.7	-1.4
Medication: Omeprazole (e.g. Zanprol)	2.1	2.6	5.3	-2.3	-1.4	-0.5	-2.3	-0.3
Primary Biliary Cirrhosis	2.0	2.9	9.0	1.9	1.1	0.5	3.0	0.7
Peak expiratory flow (PEF)	2.0	4.7	6.1	-2.5	-2.2	-2.2	-1.8	-2.1
Migraine (self-reported)	2.0	2.5	4.1	-1.1	-1.9	-2.0	-1.0	-1.5
Whole body fat mass	2.0	8.4	20.6	-4.5	-3.6	0.7	-2.6	-1.2
Arm predicted mass (right)	2.0	10.0	21.3	-4.6	-3.8	0.3	-3.5	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	5.2	2.0	0.5	0.4	1.5	2.3
Alcohol drinker status: Never	2.0	2.4	6.1	-1.0	-2.5	-1.1	-1.2	-1.5
Crohns Disease (2012)	1.9	3.0	4.7	2.1	0.0	1.4	2.2	1.9
Height	1.9	37.2	61.0	-7.5	-6.9	-3.6	-7.8	-2.9
Allergy or Eczema	1.9	5.0	7.8	-2.8	-2.1	-2.0	-2.5	-1.6
Leg fat-free mass (left)	1.9	10.2	22.6	-4.8	-3.6	0.6	-3.8	-0.8
Leg predicted mass (left)	1.9	10.2	22.8	-4.8	-3.5	0.7	-3.8	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.2	17.7	-1.3	-2.4	-4.2	-2.0	-1.3
Arm fat mass (right)	1.9	7.8	20.4	-4.5	-3.1	1.0	-2.6	-1.1
Ever highly irritable/argumentative for 2 days	1.9	2.2	4.9	-0.3	-1.6	-1.8	0.4	-2.2
Hypothyroidism/myxoedema (self-reported)	1.9	3.6	6.7	-2.1	-2.6	-0.6	-2.5	-0.5
Leg fat-free mass (right)	1.9	10.1	22.4	-4.7	-3.5	0.5	-3.9	-0.8
Leg predicted mass (right)	1.9	10.2	22.5	-4.7	-3.5	0.5	-3.9	-0.9
Arm fat mass (left)	1.9	7.8	19.4	-4.4	-3.3	0.9	-2.5	-1.2
Worry (Nagel 2018)	1.8	3.8	8.5	2.9	1.1	0.9	2.1	2.0
Cardiovascular Disease	1.8	5.9	13.3	3.6	1.2	-3.3	1.5	-1.4
Hip circumference	1.8	7.7	16.5	-4.1	-3.2	1.5	-3.2	-0.1
Lung cancer (father)	1.8	2.1	3.5	-1.4	-1.4	-1.1	-1.3	-1.9
Forced vital capacity (FVC), Best measure	1.8	6.6	18.2	-1.3	-2.6	-4.3	-2.0	-1.6
Illnesses of father: High blood pressure	1.8	2.3	7.4	-0.0	1.6	2.7	-0.4	1.1
Myopia	1.8	2.6	5.1	1.4	1.6	1.9	2.2	0.4
Verbal and Numeric Reasoning (VNR)	1.7	4.0	8.3	0.7	1.7	2.8	0.8	2.9
Prostate Cancer	1.7	2.4	5.2	-1.4	-1.4	-1.4	-1.0	-2.3
Maternal smoking around birth	1.7	2.5	5.0	-1.2	-1.0	-2.0	-1.0	-2.2
Trunk fat mass	1.7	7.4	18.4	-4.3	-3.2	0.9	-2.7	-0.8
Waist circumference	1.7	6.1	16.7	-4.1	-2.5	1.4	-1.8	-1.4
Pulse rate	1.7	2.8	7.5	-2.7	-1.5	-0.8	-1.0	-1.6
Nervous feelings	1.6	3.0	7.1	2.2	0.6	1.5	0.8	2.7
Pulse wave peak to peak time	1.6	1.9	3.9	0.5	2.0	1.3	-1.2	1.5
Comparative height size at age 10	1.6	8.7	16.9	-3.7	-2.8	-1.9	-4.1	-1.3
Eye problems/disorders: Cataract	1.6	1.8	4.6	-1.5	-2.1	-0.8	-1.2	-0.5
Body mass index (BMI)	1.5	6.2	16.2	-4.0	-2.7	1.4	-2.0	-1.1
Medication: Simvastatin	1.5	2.2	6.2	2.5	1.4	-1.6	-0.4	-0.1
Mother’s age at death	1.5	1.9	5.1	-1.9	-0.9	2.2	-0.2	-0.1
Ever depressed for a whole week	1.5	1.8	3.8	-1.0	-1.7	-1.2	-0.4	-2.0
Heart attack/myocardial infarction (self-reported)	1.5	1.9	5.1	-0.0	-1.6	-2.3	-1.3	-0.6
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	5.2	-1.5	-2.3	-0.9	-1.0	-0.6
Bipolar Disorder or Schizophrenia	1.4	3.4	6.3	0.4	-2.0	-2.5	1.3	-2.2
Intelligence (Savage-Jansen 2018)	1.4	4.2	7.8	1.1	2.1	2.4	1.3	2.8
Systolic Blood Pressure	1.4	6.8	14.5	3.8	3.2	0.5	2.9	-1.0
Chronotype (morning person)	1.4	3.3	10.1	-1.0	-1.4	-3.2	-1.2	-1.5
Diabetes (father)	1.4	1.8	3.0	0.2	1.5	1.7	1.5	1.2
Hayfever, allergic rhinitis or eczema	1.4	2.9	4.2	-1.9	-1.5	-2.1	-1.5	-1.4
Illnesses of siblings	1.4	2.0	6.7	-0.0	-1.8	-2.6	0.0	-0.1
Noisy workplace	1.4	1.7	4.6	0.6	0.8	2.2	0.4	1.7
Eye problems/disorders: None of the above	1.4	1.7	3.0	1.7	1.6	-0.2	1.1	1.1
Hearing difficulty/problems: Yes	1.3	2.0	4.0	-1.2	-1.9	-0.5	-2.0	-0.9
Medication for hormone replacement therapy	1.3	1.4	3.4	-0.9	-1.2	-1.8	-0.9	-0.9
Qualifications: None of the above	1.3	2.9	5.3	-1.0	-2.3	-2.3	-0.8	-1.5
Heart attack	1.3	1.7	4.7	0.1	-1.5	-2.2	-1.1	-0.5
Father’s age at death	1.3	1.7	5.0	-2.2	-0.1	1.3	-1.0	-1.1
Prospective memory result	1.3	1.7	3.6	0.8	-1.6	-1.9	0.8	-1.0
Standing height	1.3	12.7	24.4	-4.4	-3.9	-1.8	-4.9	-1.1
Qualifications: College or University degree	1.3	4.1	9.0	1.4	3.0	2.0	1.2	2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	8.6	-1.0	-1.2	-2.9	-0.9	-1.3
Supplements: Fish oil (including cod liver oil)	1.3	1.6	3.5	1.4	0.3	-1.2	1.9	-1.1
Leg fat percentage (left)	1.3	4.8	13.6	-3.7	-2.4	0.9	-1.5	-1.2
Average weekly spirits intake	1.2	1.5	4.1	-2.0	-1.2	-0.5	-1.2	-0.6
Frequency of depressed mood in last 2 weeks	1.2	1.6	3.2	0.2	-1.6	-1.8	0.7	-1.3
High blood pressure (mother)	1.2	1.6	5.6	-1.6	-0.3	-0.1	0.1	-2.4
Financial difficulties in last 2 years	1.2	1.6	3.5	-1.9	-1.4	-0.1	-1.1	-1.1
Mouth/teeth dental problems	1.2	1.8	5.1	-0.8	-1.1	-1.4	-0.0	-2.3
Pulse wave reflection index	1.2	1.5	3.6	-0.4	-1.9	-1.2	0.7	-1.3
Gout (self-reported)	1.2	1.7	2.4	-1.5	-1.4	-1.5	-0.7	-1.2
Leg fat percentage (right)	1.2	4.3	12.0	-3.5	-2.4	0.9	-1.3	-1.2
Medication: Aspirin	1.2	1.6	5.9	0.1	-1.2	-2.4	-0.2	-0.9
Medication: Aspirin	1.2	1.6	5.5	-0.0	-0.9	-2.4	-0.3	-1.2
Financial situation satisfaction	1.2	1.5	3.2	-0.3	-1.1	-1.7	-0.1	-1.8
Reaction Time	1.1	2.0	3.7	-0.9	-1.9	-1.4	-1.1	-1.6
Hypothyroidism (self reported)	1.1	2.4	7.7	-1.6	-1.3	0.2	-2.8	0.3
Sensitivity / hurt feelings	1.1	1.9	4.8	1.4	1.0	1.1	2.2	0.7
Vitamin and mineral supplements	1.1	1.4	2.5	0.6	1.4	1.6	-0.3	1.5
Fed-up feelings	1.1	2.1	4.8	2.2	0.0	-0.3	2.1	1.0
Had menopause	1.1	1.4	2.3	-1.5	-1.1	-0.8	-0.9	-1.4
Had other major operations	1.1	1.3	2.7	-1.6	-1.1	-0.3	-0.8	-1.3
Mouth/teeth dental problems: Dentures	1.1	1.9	4.4	-1.1	-2.1	-1.5	-0.6	-1.1
Glaucoma (self-reported)	1.1	1.3	2.6	-1.5	-0.2	1.1	-1.6	-0.4
Had major operations	1.1	1.2	2.3	1.3	0.0	1.4	1.5	0.5
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.6	0.8	-0.5	-1.6	1.6	-0.7
Friendships satisfaction	1.1	1.4	4.6	0.9	0.5	-2.1	1.1	0.1
Risk taking	1.1	1.6	4.7	0.8	1.3	2.2	0.4	0.9
Diastolic blood pressure, automated reading	1.1	3.5	6.3	-2.3	-1.9	-1.2	-1.0	-2.5
Lupus	1.0	1.5	3.1	1.5	0.3	0.8	1.2	1.8
Blood Eosinophil Count	1.0	7.5	18.2	-0.2	4.3	3.9	0.3	2.0
Blood clot in the leg (DVT)	1.0	1.3	4.2	-1.2	-2.1	-0.6	-0.7	-0.3
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.9	0.7	1.2	1.7	1.0	0.9
Body fat percentage	1.0	4.0	11.0	-3.3	-2.2	1.1	-1.5	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	4.5	-0.8	-2.1	-0.9	-0.4	-0.1
Miserableness	1.0	1.7	3.7	1.5	-0.5	-1.6	1.9	-0.4
Medication: Bendroflumethiazide	1.0	1.6	3.6	1.1	1.9	1.3	1.0	0.7
Pack years of smoking	1.0	1.5	2.7	-1.1	-1.1	-1.6	-0.2	-1.5
Diabetes (mother)	0.9	1.1	4.0	-2.0	-0.1	1.1	-0.2	-0.4
Pack years adult smoking proportion	0.9	1.4	3.0	-0.9	-1.1	-1.7	-0.1	-1.4
Trunk fat percentage	0.9	3.6	9.8	-3.1	-2.0	1.3	-1.5	-0.4
Serious illness, injury or assault to yourself	0.9	1.1	3.0	0.8	0.0	-0.7	1.7	-1.1
Supplements: Glucosamine	0.9	1.1	3.7	1.0	0.3	0.7	1.9	0.6
Arm fat percentage (right)	0.9	3.7	10.1	-3.2	-2.0	1.4	-1.5	-0.6
Happiness	0.9	1.1	2.7	-0.6	-1.5	-1.6	-0.2	-0.5
Wheeze or whistling in the chest in last year	0.9	1.6	3.0	-1.7	-1.3	1.5	-1.0	-0.4
Knee pain experienced in last month	0.9	1.4	2.5	-1.5	-1.6	-0.2	-0.4	-1.4
Smoking status: Previous	0.9	1.3	2.9	-1.1	-0.5	-1.7	-1.1	-1.1
Arm fat percentage (left)	0.9	3.4	9.4	-3.1	-1.9	1.5	-1.3	-0.5
Average weekly red wine intake	0.9	1.3	3.8	0.0	1.9	1.6	0.3	0.5
Mood swings	0.9	1.7	3.6	1.2	-1.7	-1.9	0.7	0.2
Ever smoked	0.9	1.6	3.0	-1.4	-0.6	-1.7	-0.5	-1.6
Commuting to job workplace: Cycle	0.9	1.0	2.0	-0.5	-1.0	-1.4	-0.2	-1.4
Impedance of whole body	0.9	4.7	10.2	3.2	2.6	-0.6	2.1	1.3
Neuroticism (Nagel 2018)	0.8	1.9	3.8	1.9	-0.0	0.1	1.8	1.6
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.6	-0.4	-1.1	-1.2	-0.3	-1.3
Past tobacco smoking	0.8	1.4	2.4	1.4	0.4	1.6	0.9	1.3
Impedance of arm (left)	0.8	3.9	8.4	2.9	2.3	-0.6	1.8	1.5
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.3	0.1	1.2	1.0	-0.5	1.5
Shortness of breath walking on level ground	0.8	1.0	2.2	0.6	1.2	0.9	1.5	-0.1
Mean time to correctly identify matches	0.8	1.5	2.9	-1.0	-1.7	-0.9	-1.2	-1.2
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	4.5	0.3	-0.6	-2.1	-0.1	-0.5
Long-standing illness, disability or infirmity	0.8	1.2	2.5	-1.4	-1.6	0.8	-0.6	-0.8
Irritability	0.8	1.4	4.2	-0.2	-2.1	-1.5	0.3	-0.8
Age started oral contraceptive pill	0.8	1.1	2.6	-1.2	-0.7	-0.7	-0.3	-1.6
Depression (Nagel 2018)	0.7	1.1	2.2	0.8	-1.5	-1.4	0.7	-0.1
Breast Cancer	0.7	1.8	3.7	-0.6	-1.9	-1.2	-1.7	0.8
HbA1C	0.7	0.8	1.6	0.7	0.7	0.9	0.6	1.2
Blood Platelet Count	0.7	8.0	25.5	2.1	0.9	2.8	5.0	1.2
Angina	0.7	0.9	2.5	1.1	0.3	-1.6	-0.1	0.8
Multivitamins +/- minerals	0.7	0.9	1.4	0.2	-0.9	-0.9	1.2	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.0	-0.4	1.3	1.4	-0.3	-0.1
Depression (self-reported)	0.7	0.9	2.0	0.7	0.2	1.4	-0.3	1.3
Length of working week for main job	0.7	0.7	1.8	-0.8	-0.7	-1.3	-0.4	-0.6
Tense / ‘highly strung’	0.7	1.2	3.9	2.0	0.6	0.1	1.2	-0.1
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	3.1	-1.1	0.9	1.8	0.2	0.9
Comparative body size at age 10	0.7	1.9	3.0	-1.3	-1.4	-1.7	-1.0	-1.5
Worry too long after embarrassment	0.7	1.2	2.2	-1.5	-1.1	-0.5	-0.2	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	2.3	1.2	-0.4	-1.5	0.5	-0.2
Neck or shoulder pain in last month	0.7	1.0	1.7	1.3	0.4	0.5	1.3	1.1
Medication: Seretide 50 evohaler	0.7	0.8	2.6	0.1	-0.3	1.0	0.4	1.6
Chest pain or discomfort	0.7	1.1	2.2	-1.0	-1.5	-0.9	-0.9	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	4.6	-0.8	-2.1	-0.7	-1.1	0.6
Qualifications: nursing, teaching	0.7	1.1	1.9	0.9	0.6	1.4	1.2	1.0
Commuting to job workplace: Walk	0.7	0.8	1.7	-1.3	-0.8	-0.1	-1.2	-0.5
Breast cancer (self-reported)	0.7	0.8	1.4	-0.2	-1.1	-1.2	0.3	-1.1
Medication: Gliclazide	0.7	0.8	1.7	-1.1	1.0	1.3	-0.4	0.2
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.7	-1.0	-1.3	0.9	-0.6	-0.5
Depressed Affect (Nagel 2018)	0.6	1.3	1.8	1.1	-1.3	-1.1	1.2	0.8
Respiratory disease	0.6	1.3	5.1	-0.6	1.0	2.3	0.1	0.5
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.8	-0.0	0.1	1.7	1.5	0.3
Ever had hysterectomy (womb removed)	0.6	0.7	1.5	0.7	0.5	1.2	1.1	-0.3
Age when periods started (menarche)	0.6	1.5	3.0	-0.9	1.7	1.5	-0.6	1.0
Neuroticism score	0.6	1.3	3.1	1.5	-0.9	-0.5	1.8	0.4
Impedance of arm (right)	0.6	3.0	6.7	2.6	1.9	-1.0	1.4	1.3
Age at first live birth	0.6	1.1	2.2	1.4	1.5	0.8	0.8	-0.0
Angina (self-reported)	0.6	0.8	2.9	0.7	-0.0	-1.7	-0.5	0.6
Heart disease (mother)	0.6	0.7	2.0	-0.6	1.0	1.4	-0.4	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.9	-1.4	-0.8	-0.6	-0.4	-0.6
Pulse rate, automated reading	0.6	2.0	5.2	-2.3	-2.0	-0.0	-0.6	-0.6
Number of full sisters	0.6	0.8	2.3	0.3	-0.4	1.1	0.1	1.5
Age at last live birth	0.6	0.9	1.9	1.2	0.9	0.3	1.4	-0.0
Medication for cholesterol	0.6	0.9	2.0	-1.4	-1.0	1.2	-0.3	0.4
Mineral and other dietary supplements	0.6	0.8	2.4	-1.1	-0.4	0.4	-1.6	0.2
Alcohol drinker status: Previous	0.6	0.7	1.7	0.0	-1.3	-1.2	0.1	-0.5
Irritable Bowel Disease (IBD)	0.5	1.2	2.8	0.2	1.6	1.7	0.1	0.9
Ulcerative Colitis (UC)	0.5	1.0	2.6	-0.8	1.1	1.6	-0.8	0.2
Waist Hip Ratio (WHR)	0.5	2.5	6.2	0.1	1.3	0.8	2.5	-2.0
Lung FEV1/FVC ratio	0.5	2.6	6.4	-1.4	-1.9	-2.5	-0.4	-0.8
Neuroticism	0.5	1.2	3.4	1.3	-0.7	-0.6	1.8	0.3
Medication: Metformin	0.5	0.7	2.5	-1.1	0.1	1.6	-0.1	0.1
Impedance of leg (right)	0.5	2.4	5.2	2.3	1.7	-1.2	1.7	0.4
Taking other prescription medications	0.5	0.8	1.6	-1.3	-0.9	0.3	-0.6	-1.0
Qualifications: CSEs or equivalent	0.5	0.7	1.3	0.9	-1.1	-1.1	0.4	0.3
Stomach or abdominal pain in last month	0.5	0.6	2.3	-0.0	-0.4	0.7	0.1	1.5
Number of incorrect matches in round	0.5	0.9	1.7	0.4	-1.1	-1.3	-1.0	-0.5
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.6	-0.1	-1.1	-1.3	0.1	-0.6
Diabetes (self-reported)	0.5	0.8	2.2	-0.3	0.4	1.5	0.7	0.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.5	-1.1	-1.2	-0.5	-0.3	-0.1
Medication: Ramipril	0.5	0.6	1.1	-0.2	-0.6	-0.9	0.8	-1.1
Time employed in main current job	0.5	0.6	1.5	0.7	0.6	1.2	0.4	0.8
Number of live births	0.5	0.7	1.3	-1.1	-1.1	-0.1	-0.9	0.3
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.2	0.5	1.5	1.5	0.8	0.4
Breastfed as a baby	0.5	0.6	1.6	-0.4	-1.1	-1.3	-0.5	-0.1
Suffer from ‘nerves’	0.5	0.8	1.6	1.1	0.1	0.8	0.6	1.3
Illnesses of father: Heart disease	0.5	0.7	1.6	0.7	1.2	0.6	-0.6	0.9
Diabetes diagnosed by doctor	0.5	0.9	2.4	-1.1	0.4	1.5	0.6	0.5
Guilty feelings	0.5	0.8	1.9	1.4	0.4	0.5	0.7	1.1
Eye problems/disorders: Glaucoma	0.5	0.6	1.0	-0.8	0.5	0.9	-1.0	-0.2
Pain experienced in last month	0.5	0.8	2.3	1.2	1.5	0.1	0.0	0.6
Age at First Birth	0.4	0.6	1.6	1.3	0.4	0.0	1.1	-0.4
Neuroticism (2016)	0.4	0.6	1.1	0.6	-1.0	-0.7	0.4	1.1
Rheumatoid Arthritis	0.4	0.6	1.8	0.4	0.8	1.3	-0.4	0.5
Hair Pigment	0.4	10.1	19.2	-2.2	-4.4	-4.1	-1.7	-2.6
Medication: Co-codamol	0.4	0.5	1.1	0.3	-0.8	0.8	0.0	1.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.3	0.9	-0.2	-0.3	1.2	0.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.4	-1.2	-0.8	-0.3	0.1	-0.4
Medication: Levothyroxine sodium	0.4	0.7	2.0	-0.6	-1.4	0.1	-1.0	0.2
Sitting height	0.4	3.1	8.0	-1.9	-1.7	-0.9	-2.8	-0.3
Impedance of leg (left)	0.4	2.1	4.3	2.1	1.6	-1.2	1.5	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.5	1.2	0.6	0.1	1.1	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.3	0.2	-0.3	-0.7	1.5	-0.4
Medication: Lansoprazole	0.4	0.4	1.0	0.5	0.6	0.3	1.0	0.7
Birth weight of first child	0.4	0.8	3.1	0.3	-0.3	0.6	-0.6	1.8
Exposure to tobacco smoke outside home	0.4	0.5	1.6	-0.3	-1.2	-0.1	-0.5	0.6
Medication for pain relief, constipation, heartburn	0.4	0.7	2.7	0.1	1.6	0.4	0.3	-0.6
Medication: Blood pressure	0.4	0.6	1.6	0.6	-0.3	-0.6	0.9	-1.3
Overall health rating	0.4	0.9	4.0	0.0	-2.0	-0.4	0.6	-0.1
Loneliness, isolation	0.4	0.6	2.1	-0.6	-1.5	-0.4	-0.7	0.1
Number of operations (self-reported)	0.4	0.6	1.2	-1.0	-1.1	0.7	-0.6	0.0
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.0	-0.3	-1.0	-0.7	0.6	-0.6
Fractured/broken bones in last 5 years	0.4	0.5	1.3	0.7	0.3	0.6	1.2	0.4
Heart disease (siblings)	0.4	0.5	0.9	-0.2	0.6	0.7	-1.0	0.9
Schizophrenia (2018)	0.3	0.6	1.0	1.0	-0.5	-0.6	1.0	-0.7
Ovarian Cancer	0.3	0.5	1.0	0.3	0.2	0.9	1.0	-0.5
Mean Putamen Volume	0.3	0.4	0.9	-0.9	0.4	0.2	-0.4	-0.8
Schizophrenia (2014)	0.3	0.7	1.6	1.1	0.2	-0.1	1.3	-0.8
Blood Red Count	0.3	2.7	7.8	-2.8	-1.0	0.9	-1.9	0.4
Smoking Status	0.3	0.7	1.9	-0.6	-0.5	-1.0	0.0	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.0	0.8	-1.0	-0.3	0.7	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.7	-1.1	-0.8	0.2	-1.3	-0.3
Chronic bronchitis/emphysema (father)	0.3	0.4	0.9	-0.8	-1.0	0.0	-0.4	0.2
Pain all over the body in last month	0.3	0.3	0.4	0.6	0.7	0.6	-0.5	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.2	-0.3	-0.5	1.1	0.3	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.8	0.7	-0.5	-0.9	0.8	0.0
Headache pain in last month	0.3	0.4	1.4	-0.1	-0.7	0.4	0.4	1.2
Number of children fathered	0.3	0.3	0.9	-0.2	0.1	0.6	-0.9	0.4
Emphysema/chronic bronchitis	0.3	0.3	0.9	-0.7	-0.3	1.0	-0.1	0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.7	-0.3	0.3	0.6	-0.8	0.8
Illnesses of siblings: Diabetes	0.3	0.4	1.3	-0.8	-0.2	0.4	-0.2	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.4	-0.5	-0.4	-0.5	-0.6	-0.6
Osteoarthritis (self-reported)	0.3	0.3	1.1	-0.3	-1.1	-0.4	0.3	-0.5
Smoking status: Current	0.3	0.4	1.1	0.5	0.0	0.9	1.1	-0.3
Medication: Paracetamol	0.3	0.4	1.6	-0.5	-1.3	0.2	0.1	-0.2
Average weekly beer plus cider intake	0.3	0.4	0.9	0.7	-0.2	-1.0	0.6	-0.5
Crohns Disease (2017)	0.2	0.5	1.2	0.6	1.1	0.5	0.5	0.5
Ulcerative Colitis	0.2	0.3	0.9	-0.5	0.0	0.2	-1.0	-0.3
Systolic blood pressure, automated reading	0.2	0.7	2.9	-0.3	0.1	-0.6	-0.2	-1.7
Severe depression (siblings)	0.2	0.2	0.4	0.7	0.5	-0.2	0.3	0.5
Townsend deprivation index at recruitment	0.2	0.3	0.6	-0.7	0.3	-0.2	-0.8	-0.7
Current tobacco smoking	0.2	0.3	0.6	0.1	-0.5	0.6	0.8	-0.7
Relative age voice broke	0.2	0.3	0.9	-1.0	-0.2	0.1	-0.6	-0.0
High blood pressure	0.2	0.5	1.8	0.2	0.7	-0.3	0.3	-1.4
Hearing difficulty/problems with background noise	0.2	0.3	0.9	0.2	-0.5	1.0	-0.6	0.4
Hair/balding pattern: Pattern 2	0.2	0.2	0.8	0.5	-0.0	-0.4	-0.9	-0.3
Allergy	0.2	0.4	0.8	0.9	0.9	0.7	0.3	0.3
Falls in the last year	0.2	0.2	0.4	0.4	-0.5	-0.6	-0.3	0.5
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	0.5	0.4	0.3	0.9	0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.2	-0.5	0.4	0.5	0.1	-1.1
Medication: Paracetamol	0.2	0.3	1.1	-0.5	-1.0	0.4	-0.1	-0.0
Medication: Amlodipine	0.2	0.3	1.1	0.0	0.5	-0.2	0.5	-1.1
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.5	0.6	0.6	0.2	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	0.8	-0.3	0.2	0.6	-0.2
Medication: Ibuprofen	0.2	0.3	1.1	-0.2	-0.1	1.1	0.2	0.4
Medication: Allopurinol	0.2	0.3	0.7	-0.8	-0.3	-0.6	-0.4	-0.2
Leg pain on walking	0.2	0.3	0.5	-0.6	-0.5	0.7	0.2	-0.3
Hypertension (Self-reported)	0.2	0.6	1.3	0.5	0.9	-0.0	0.7	-1.2
Asthma (self-reported)	0.2	0.4	1.6	-0.3	0.3	1.3	0.1	0.5
Average weekly champagne plus white wine intake	0.2	0.3	0.6	0.5	0.4	0.7	0.8	-0.3
Ever taken oral contraceptive pill	0.2	0.2	0.4	-0.6	0.5	0.2	-0.1	0.6
Medication: Blood pressure	0.2	0.4	0.9	-0.3	0.9	0.3	-0.2	-0.9
Unable to work because of sickness or disability	0.2	0.3	0.7	0.6	0.1	-0.6	0.0	0.9
Supplements: Calcium	0.2	0.3	0.5	-0.3	-0.7	-0.4	-0.4	-0.6
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	0.3	0.4	-0.8	0.5	-0.1
Fasting Glucose	0.1	0.1	0.4	-0.3	0.1	0.6	-0.0	0.0
Heel T-Score	0.1	0.6	1.0	-0.5	-0.8	-1.0	-0.6	-0.9
Tanning	0.1	0.9	3.5	-0.8	-0.6	-0.4	-1.9	-0.3
Number of treatments/medications taken	0.1	0.2	0.4	0.7	-0.2	-0.5	0.0	-0.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.6	-0.2	-0.4	0.8	0.2	-0.1
Supplements: Zinc	0.1	0.1	0.3	0.0	-0.0	-0.6	-0.2	0.2
Medication: Atenolol	0.1	0.1	0.4	0.2	-0.1	-0.6	-0.4	0.0
Asthma	0.1	0.3	1.1	-0.4	0.1	1.0	-0.0	0.3
Hair/balding pattern: Pattern 4	0.1	0.3	1.0	-0.6	-0.3	0.3	-0.3	1.0
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.4	-0.4	0.0	-0.1	-0.6	0.6
Family relationship satisfaction	0.1	0.1	0.3	-0.2	-0.1	-0.6	-0.3	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.2	-0.5	-0.2	0.4	-0.1
Osteoporosis (self-reported)	0.1	0.2	0.3	-0.2	0.5	0.4	0.4	0.5
Number of self-reported non-cancer illnesses	0.1	0.2	0.9	0.4	-1.0	-0.1	-0.2	0.1
Commuting to job workplace: Public transport	0.1	0.2	0.6	-0.3	-0.2	-0.2	-0.3	-0.7
Medication: Lisinopril	0.1	0.1	0.3	0.0	0.6	0.3	-0.1	-0.3
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.5	-0.0	-0.4	0.5	0.2	1.2
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.1	0.3	-0.3	0.4	-0.1	0.3

Hub : Genes

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Trait associations