[Hub]/) : Traits : Lung FVC : ← →

chr20:29,522,520-31,494,382

Best TWAS P=4.63e-14 · Best GWAS P=1.79e-13 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Brain Nucleus accumbens basal ganglia	COX4I2	0.13	0.14	lasso	5	0.05	2.2e-02	-5.6	-5.3	1.3e-07	0.84	0.04	0.71	FALSE
2	GTEx	Cells Transformed fibroblasts	REM1	0.06	0.00	lasso	3	0.01	6.7e-02	-3.5	-5.1	3.0e-07	0.57	0.09	0.84	FALSE
3	GTEx	Esophagus Mucosa	HM13	0.06	0.01	lasso	5	0.00	2.7e-01	-7.2	-7.5	4.6e-14	0.95	0.03	0.77	TRUE
4	GTEx	Esophagus Muscularis	COX4I2	0.09	0.12	enet	10	0.09	4.1e-06	-5.7	-5.8	8.1e-09	0.77	0.43	0.56	FALSE
5	GTEx	Heart Left Ventricle	COX4I2	0.06	0.05	lasso	6	0.01	6.2e-02	-7.3	-7.0	3.8e-12	0.96	0.04	0.95	FALSE
6	GTEx	Lung	COX4I2	0.05	0.01	enet	6	0.03	1.8e-03	-5.6	-5.2	2.3e-07	0.74	0.25	0.27	FALSE
7	GTEx	Muscle Skeletal	COX4I2	0.10	0.08	lasso	4	0.09	3.5e-09	-5.7	-5.8	5.1e-09	0.75	0.30	0.70	FALSE
8	GTEx	Nerve Tibial	COX4I2	0.13	0.10	lasso	9	0.07	6.6e-06	-5.7	-5.6	2.6e-08	0.68	0.61	0.36	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	COX4I2	0.08	0.05	lasso	4	0.05	1.5e-03	-5.6	-5.7	1.1e-08	0.77	0.40	0.41	FALSE
10	GTEx	Skin Sun Exposed Lower leg	TPX2	0.05	0.00	lasso	3	0.00	5.5e-01	-4.2	-6.4	1.2e-10	0.83	0.03	0.85	FALSE
11	GTEx	Skin Sun Exposed Lower leg	COX4I2	0.03	0.04	enet	6	0.04	3.6e-04	-5.6	-6.0	2.4e-09	0.80	0.12	0.83	FALSE
12	GTEx	Testis	DUSP15	0.10	0.01	lasso	8	0.00	3.1e-01	-5.9	-5.8	6.5e-09	0.58	0.05	0.38	FALSE
13	GTEx	Thyroid	COX4I2	0.04	0.05	lasso	2	0.03	1.8e-03	-5.6	-5.6	2.1e-08	0.74	0.11	0.77	FALSE
14	METSIM	Adipose	TPX2	0.05	0.01	blup	323	0.04	4.2e-06	-5.0	-7.4	1.2e-13	0.86	0.02	0.98	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	COX4I2	0.12	0.04	enet	18	0.07	7.8e-10	-7.1	-6.5	1.2e-10	0.76	0.04	0.96	FALSE
16	YFS	Blood	PLAGL2	0.02	0.00	bslmm	312	0.01	3.1e-03	3.0	6.6	3.7e-11	-0.36	0.04	0.06	TRUE
17	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	COX4I2	0.06	0.02	blup	25	0.04	2.6e-04	-7.1	-7.0	3.4e-12	0.88	0.00	0.98	FALSE
18	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TPX2	0.05	0.00	blup	49	0.01	5.1e-02	-7.2	-7.3	3.2e-13	0.93	0.01	0.80	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	COX4I2	0.08	0.06	enet	7	0.06	3.3e-13	-7.1	-6.6	4.0e-11	0.83	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	COX4I2	0.06	0.03	lasso	3	0.03	1.5e-04	-7.1	-6.9	4.2e-12	0.90	0.01	0.98	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	BCL2L1	0.05	0.03	enet	8	0.02	9.4e-04	-7.2	-6.0	1.8e-09	0.87	0.01	0.93	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	DUSP15	0.05	0.02	enet	8	0.04	3.1e-05	-7.2	-7.0	3.6e-12	0.82	0.00	0.99	FALSE
23	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	COX4I2	0.04	0.03	blup	25	0.04	2.5e-05	-7.3	-7.0	2.4e-12	0.94	0.01	0.99	FALSE
24	The Cancer Genome Atlas	Prostate Adenocarcinoma	COX4I2	0.07	0.07	lasso	5	0.07	2.0e-07	-5.6	-6.2	6.9e-10	0.80	0.15	0.84	FALSE
25	The Cancer Genome Atlas	Rectum Adenocarcinoma	DUSP15	0.17	0.11	blup	44	0.13	6.6e-04	-4.6	6.4	1.8e-10	-0.76	0.02	0.42	FALSE
26	The Cancer Genome Atlas	Testicular Germ Cell Tumors	COX4I2	0.10	0.03	blup	25	0.05	1.0e-02	-7.1	-6.5	7.7e-11	0.86	0.01	0.69	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	COX4I2	0.02	0.03	lasso	2	0.03	1.0e-03	-5.6	-5.6	1.9e-08	0.74	0.02	0.68	FALSE