[Hub]/) : Traits : Lung FVC : ← →

chr20:24,230,055-26,307,797

Best TWAS P=2.06e-11 · Best GWAS P=2.1e-11 conditioned to 0.13

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ABHD12	0.10	0.17	blup	405	0.17	1.7e-20	-6.0	-5.7	1.4e-08	0.88	0.09	0.91	FALSE
2	GTEx	Artery Aorta	PYGB	0.07	0.02	lasso	9	0.02	3.4e-02	-5.3	-6.1	9.6e-10	0.72	0.10	0.57	FALSE
3	GTEx	Artery Aorta	ABHD12	0.06	0.03	enet	6	0.03	5.4e-03	-5.6	-5.3	1.3e-07	0.85	0.15	0.78	FALSE
4	GTEx	Artery Aorta	NINL	0.17	0.18	lasso	6	0.19	1.5e-10	-5.8	-5.5	4.7e-08	0.90	0.15	0.85	FALSE
5	GTEx	Artery Tibial	ABHD12	0.12	0.12	enet	25	0.15	7.1e-12	-5.4	-5.6	2.3e-08	0.89	0.18	0.82	FALSE
6	GTEx	Brain Caudate basal ganglia	ABHD12	0.09	0.05	enet	13	0.04	2.9e-02	-5.8	-5.8	5.1e-09	0.91	0.12	0.65	FALSE
7	GTEx	Brain Cerebellar Hemisphere	ENTPD6	0.22	0.26	lasso	3	0.17	3.8e-05	-6.1	6.1	9.1e-10	-0.96	0.05	0.95	FALSE
8	GTEx	Brain Cerebellum	ENTPD6	0.15	0.23	enet	8	0.14	4.6e-05	-5.8	5.7	1.6e-08	-0.95	0.05	0.94	FALSE
9	GTEx	Brain Cortex	ABHD12	0.08	0.11	lasso	8	0.09	1.4e-03	-5.9	-5.3	1.3e-07	0.88	0.11	0.62	FALSE
10	GTEx	Breast Mammary Tissue	CST7	0.10	0.00	lasso	4	0.00	7.3e-01	4.6	-5.5	4.5e-08	0.82	0.07	0.68	FALSE
11	GTEx	Breast Mammary Tissue	VN1R108P	0.11	0.03	enet	16	0.05	1.7e-03	-5.2	-5.1	2.7e-07	0.50	0.26	0.42	FALSE
12	GTEx	Cells Transformed fibroblasts	ABHD12	0.24	0.33	lasso	4	0.35	6.3e-27	-5.8	-5.9	4.1e-09	0.91	0.25	0.75	FALSE
13	GTEx	Cells Transformed fibroblasts	GINS1	0.04	0.01	lasso	3	0.01	5.2e-02	-5.2	-6.2	6.8e-10	0.77	0.22	0.65	FALSE
14	GTEx	Colon Sigmoid	ABHD12	0.17	0.17	lasso	15	0.17	1.0e-06	-5.4	-5.5	2.9e-08	0.86	0.17	0.83	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	ABHD12	0.15	0.14	lasso	13	0.14	7.0e-06	-6.2	-5.5	3.0e-08	0.94	0.14	0.86	FALSE
16	GTEx	Esophagus Muscularis	ABHD12	0.10	0.10	enet	42	0.09	4.5e-06	-6.1	-5.6	1.7e-08	0.83	0.12	0.88	FALSE
17	GTEx	Heart Atrial Appendage	ABHD12	0.07	0.06	enet	16	0.06	1.0e-03	-6.1	-6.0	1.8e-09	0.92	0.14	0.84	FALSE
18	GTEx	Heart Left Ventricle	ABHD12	0.15	0.14	lasso	10	0.12	4.0e-07	-6.0	-6.1	1.0e-09	0.91	0.15	0.85	FALSE
19	GTEx	Liver	ABHD12	0.20	0.20	lasso	19	0.15	7.3e-05	-6.4	-6.6	4.3e-11	0.93	0.09	0.91	FALSE
20	GTEx	Muscle Skeletal	ENTPD6	0.04	0.02	lasso	4	0.01	1.5e-02	-5.3	5.3	8.9e-08	-0.84	0.09	0.84	FALSE
21	GTEx	Nerve Tibial	ABHD12	0.24	0.44	lasso	11	0.44	5.1e-34	-6.0	6.0	2.6e-09	-0.92	0.12	0.88	FALSE
22	GTEx	Ovary	ABHD12	0.23	0.04	lasso	8	0.05	1.9e-02	-6.1	-5.8	7.9e-09	0.86	0.09	0.60	FALSE
23	GTEx	Pancreas	ENTPD6	0.11	0.05	enet	23	0.05	5.0e-03	-4.0	5.4	6.8e-08	-0.79	0.09	0.85	FALSE
24	GTEx	Pituitary	ABHD12	0.27	0.31	enet	25	0.31	1.8e-08	-6.4	-5.7	1.1e-08	0.88	0.08	0.92	FALSE
25	GTEx	Skin Sun Exposed Lower leg	ABHD12	0.07	0.03	lasso	10	0.05	7.3e-05	-5.8	-5.5	5.0e-08	0.93	0.06	0.94	FALSE
26	GTEx	Spleen	PYGB	0.15	0.09	lasso	6	0.04	2.6e-02	-6.4	-6.7	2.1e-11	0.90	0.08	0.83	TRUE
27	GTEx	Thyroid	ABHD12	0.05	0.04	lasso	5	0.03	3.9e-03	-6.1	6.2	5.1e-10	-0.95	0.09	0.89	FALSE
28	GTEx	Thyroid	NINL	0.13	0.18	enet	17	0.20	6.2e-15	3.9	5.5	5.0e-08	-0.80	0.66	0.34	FALSE
29	GTEx	Thyroid	VN1R108P	0.05	0.01	lasso	2	0.02	1.8e-02	-5.4	-6.4	1.2e-10	0.82	0.06	0.85	FALSE
30	GTEx	Whole Blood	PYGB	0.17	0.14	enet	22	0.18	2.7e-16	-6.4	-5.7	1.1e-08	0.88	0.04	0.96	FALSE
31	NTR	Blood	PYGB	0.07	0.10	enet	22	0.12	3.6e-36	-5.9	-5.9	3.3e-09	0.88	0.13	0.87	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	ABHD12	0.26	0.35	enet	35	0.42	7.9e-58	-5.4	-5.7	1.4e-08	0.85	0.17	0.83	FALSE
33	YFS	Blood	ABHD12	0.15	0.35	bslmm	390	0.34	2.2e-118	-5.9	-5.9	3.1e-09	0.92	0.20	0.80	FALSE
34	YFS	Blood	PYGB	0.36	0.49	enet	50	0.56	7.4e-226	-5.3	-5.5	2.8e-08	0.87	0.26	0.74	FALSE
35	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ABHD12	0.04	0.00	blup	77	0.02	6.6e-03	-6.0	-6.2	5.6e-10	0.88	0.04	0.56	FALSE
36	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PYGB	0.08	0.04	blup	74	0.06	1.0e-03	-6.1	5.5	3.4e-08	-0.91	0.03	0.89	FALSE
37	The Cancer Genome Atlas	Glioblastoma Multiforme	ABHD12	0.14	0.10	lasso	5	0.13	1.1e-04	-5.4	-5.9	4.6e-09	0.89	0.04	0.92	FALSE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ABHD12	0.04	0.03	blup	77	0.04	4.0e-05	-5.9	-6.5	1.1e-10	0.91	0.05	0.94	FALSE
39	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GINS1	0.03	0.01	enet	13	0.02	4.3e-03	-5.2	-6.3	2.7e-10	0.79	0.03	0.67	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	ABHD12	0.04	0.06	blup	77	0.06	2.2e-07	-6.0	-6.1	1.3e-09	0.93	0.06	0.94	FALSE
41	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ABHD12	0.07	0.05	blup	77	0.05	2.4e-03	-6.1	-6.0	2.4e-09	0.92	0.05	0.85	FALSE
42	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ABHD12	0.08	0.09	blup	80	0.09	1.7e-06	-5.9	-6.0	2.0e-09	0.91	0.05	0.95	FALSE
43	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ENTPD6	0.07	0.07	lasso	1	0.04	9.2e-03	-6.1	6.1	1.4e-09	-0.96	0.01	0.90	FALSE
44	The Cancer Genome Atlas	Testicular Germ Cell Tumors	NINL	0.11	0.03	blup	81	0.07	2.1e-03	4.6	5.4	8.0e-08	-0.90	0.03	0.71	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	ENTPD6	0.16	0.14	lasso	4	0.13	1.2e-12	-6.1	6.1	1.4e-09	-0.97	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	NINL	0.08	0.14	lasso	11	0.13	2.9e-12	-5.9	5.8	4.9e-09	-0.91	0.03	0.97	FALSE