Hub : Genes

DUSP15

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.3300	0.0970	9.9e-05	0.055	NA	0.124	NA	0.144	0.0013	NA	1.7e-06	NA	2.3e-07
2	GTEx	Testis	0.1020	0.0540	5.6e-03	0.011	NA	-0.005	NA	0.000	0.1000	NA	6.6e-01	NA	3.1e-01
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0483	0.0242	5.3e-04	0.009	0.015	0.010	NA	0.003	0.0270	0.00770	2.6e-02	NA	1.2e-01
4	TCGA	Brain Lower Grade Glioma	0.0530	0.0240	4.8e-06	0.022	0.037	0.038	NA	0.038	0.0014	0.00004	3.1e-05	NA	3.1e-05
5	TCGA	Rectum Adenocarcinoma	0.1710	0.0900	5.4e-03	0.107	0.128	0.067	NA	0.073	0.0018	0.00066	1.2e-02	NA	8.9e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.2	2.0	3.2	1.0	-1.4	-0.7	-1.8	1.8
Bipolar Disorder or Schizophrenia	1.1	2.6	5.1	2.3	-1.3	0.7	-1.6	1.7
Depressed Affect (Nagel 2018)	0.5	1.1	2.2	-0.7	-0.0	-1.5	1.5	-0.8
Depression (Nagel 2018)	0.7	1.0	4.1	0.3	-0.3	-2.0	0.3	-0.7
Intelligence (Savage-Jansen 2018)	0.5	1.4	5.3	-1.2	2.3	0.3	-0.2	-0.3
Neuroticism (Nagel 2018)	0.2	0.4	1.3	0.1	-1.2	-0.6	-0.1	0.4
Schizophrenia (2018)	0.7	1.6	4.1	2.0	-0.6	1.5	-0.6	0.8
Schizophrenia vs Biploar Disorder	1.0	1.3	2.8	-1.3	1.1	-0.9	0.5	-1.7
Worry (Nagel 2018)	0.4	0.9	2.1	0.2	-1.0	-0.1	-1.4	1.0
Alzheimer’s Disease (in mother)	0.3	0.3	1.3	0.3	0.3	-0.2	-1.1	0.4
Alzheimer’s Disease (in father)	1.1	1.1	2.6	1.6	-0.7	0.2	-0.8	1.4
Alzheimer’s Disease (including proxy)	1.1	1.5	2.6	1.6	-0.5	0.5	-1.6	1.5
Crohns Disease (2017)	0.6	1.3	4.8	0.6	0.3	0.9	2.2	-0.4
Irritable Bowel Disease (IBD)	1.0	2.3	6.5	1.6	0.5	1.5	2.5	0.1
Ulcerative Colitis (UC)	0.9	1.6	2.8	1.7	0.2	1.6	1.5	0.7
Major Depression (MDD)	0.8	1.0	2.7	0.5	-1.0	-0.1	-1.6	0.9
Reaction Time	0.6	1.1	3.0	-0.7	1.0	-1.7	-0.5	-0.8
Verbal and Numeric Reasoning (VNR)	2.6	6.2	12.0	-3.2	3.5	-2.0	0.5	-2.1
Breast Cancer	1.6	3.9	6.7	-1.4	2.4	-0.8	2.6	-2.2
Ovarian Cancer	0.4	0.5	2.1	1.5	0.3	-0.1	0.5	0.1
Prostate Cancer	1.0	1.4	4.4	0.9	-0.7	-0.5	-2.1	1.1
Age at First Birth	0.2	0.2	0.4	0.6	0.6	0.5	0.1	0.4
Bipolar Disorder (2011)	0.2	0.2	0.6	-0.2	0.5	-0.7	0.4	-0.1
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	0.9	-0.4	-0.4	-1.0	0.3
Coronary Artery Disease (CAD)	0.6	0.7	1.6	0.3	-0.1	1.2	1.3	0.6
Crohns Disease (2012)	0.6	1.0	1.9	1.4	-1.4	0.7	0.3	0.9
Mean Putamen Volume	8.0	9.1	16.1	2.8	-2.3	1.4	-3.7	4.0
Fasting Glucose	1.8	2.2	4.8	1.8	-1.1	2.2	0.6	1.2
HbA1C	0.8	0.9	1.1	-0.9	1.0	-1.0	1.1	-0.8
HDL Cholesterol	0.8	1.3	1.8	-1.1	0.8	-1.2	1.1	-1.3
LDL Cholesterol	0.1	0.2	0.6	-0.2	-0.0	-0.8	-0.4	-0.4
Lupus	0.3	0.4	1.2	0.5	-0.5	-0.5	-1.1	0.4
Neuroticism (2016)	0.3	0.4	0.7	0.9	-0.6	0.1	0.8	0.5
Primary Biliary Cirrhosis	0.4	0.6	1.4	0.4	-1.2	-0.4	-0.7	0.8
Rheumatoid Arthritis	0.3	0.3	1.0	-0.1	-0.8	1.0	0.1	0.2
Schizophrenia (2014)	0.1	0.2	0.5	0.7	-0.1	0.2	-0.6	0.2
Triglycerides	0.3	0.5	1.2	0.9	-0.2	1.1	0.2	0.7
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.3	0.7	-0.8	0.8	-1.1	1.0
Ulcerative Colitis	0.9	1.3	4.3	1.1	0.6	0.8	2.1	0.4
Blood Eosinophil Count	0.5	3.5	5.6	2.4	-0.7	1.6	-1.9	2.3
Blood Platelet Count	7.9	91.4	146.4	7.6	-9.4	5.0	-12.1	11.8
Blood Red Count	4.5	43.3	57.2	7.6	-6.0	7.3	-4.6	7.0
Blood White Count	0.2	1.1	2.4	1.5	-1.2	-0.4	-0.5	1.2
Heel T-Score	1.1	8.5	23.8	-2.6	1.7	-4.9	0.9	-2.9
BMI	0.1	0.5	1.0	-0.1	0.7	1.0	-0.5	-0.7
Height	1.5	29.3	35.6	-5.4	5.6	-5.0	5.0	-6.0
Waist Hip Ratio (WHR)	0.6	2.7	4.1	-1.7	1.0	-1.7	2.0	-1.7
Systolic Blood Pressure	0.9	4.3	7.0	2.2	-1.9	1.3	-2.2	2.6
Smoking Status	1.6	3.7	5.7	-1.3	1.3	-2.4	2.4	-2.0
Allergy or Eczema	0.2	0.5	1.5	1.2	0.4	0.1	0.7	0.6
Cardiovascular Disease	1.4	4.8	7.9	2.0	-1.9	2.0	-2.0	2.8
Hypothyroidism (self reported)	0.1	0.3	0.5	-0.7	0.5	0.5	0.4	-0.6
Respiratory disease	0.9	2.1	3.4	-1.8	0.9	-0.3	1.8	-1.6
Type 2 Diabetes (T2D) (2018)	1.6	2.9	4.6	2.2	-1.6	1.9	-0.3	1.9
Lung FEV1/FVC ratio	0.2	0.9	3.2	-0.2	0.1	-0.9	0.5	-1.8
Lung FVC	6.0	30.6	48.3	5.0	-5.8	2.2	-7.0	6.4
Neuroticism	0.4	0.9	2.5	0.8	-1.6	-0.7	-0.6	0.8
Chronotype (morning person)	0.7	1.6	3.2	-1.2	-0.0	-1.8	-1.8	0.2
Hair Pigment	0.4	12.5	37.9	1.7	-3.8	0.1	-6.2	2.7
Tanning	0.3	3.2	12.4	-0.1	-0.1	1.7	3.5	0.7
Hand grip strength (left)	0.8	2.1	3.5	-1.3	1.9	-1.7	-0.9	-1.4
Number of treatments/medications taken	0.8	1.4	3.3	1.2	-1.8	0.4	-0.8	1.2
Average weekly spirits intake	3.9	4.8	7.6	2.4	-2.8	1.5	-1.5	2.4
Sensitivity / hurt feelings	0.1	0.1	0.3	0.2	-0.5	-0.1	0.4	0.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.9	1.4	-0.5	-1.2	-0.1	-0.2
Hearing difficulty/problems: Yes	2.1	3.1	5.0	-1.4	1.2	-2.2	2.2	-1.6
Relative age of first facial hair	0.9	1.8	4.6	-1.1	1.0	-2.1	-0.4	-1.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.4	-0.5	0.3	-0.6	-0.0	-0.1
Ever used hormone-replacement therapy (HRT)	1.8	2.3	4.2	-1.8	0.8	-0.1	1.9	-2.0
Ever had hysterectomy (womb removed)	0.7	0.8	1.6	-0.5	-1.3	1.1	-0.2	0.8
Systolic blood pressure, automated reading	0.2	0.6	1.2	0.1	-0.4	1.0	-1.1	0.7
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.4	-0.9	0.9	-0.0	1.5	-1.6
Angina	0.1	0.1	0.4	-0.6	-0.2	0.5	0.2	0.1
Medication for hormone replacement therapy	0.2	0.2	0.6	-0.4	-0.2	-0.6	-0.0	-0.8
Vitamin and mineral supplements	1.4	1.8	2.7	-1.0	1.6	0.5	1.6	-1.6
Supplements: Zinc	2.2	2.4	3.4	1.5	-1.7	1.7	-0.7	1.8
Medication: Co-codamol	0.3	0.4	0.9	0.1	-0.9	-0.9	-0.4	-0.3
Medication: Metformin	1.3	1.8	2.9	1.4	-1.7	0.9	-0.9	1.5
Diabetes (father)	0.4	0.5	1.0	0.8	-0.7	-0.6	-1.0	0.3
Diabetes (mother)	0.5	0.6	2.3	-0.0	0.5	0.5	1.5	-0.5
Severe depression (siblings)	1.0	1.2	2.7	-1.0	1.2	0.4	1.6	-0.7
Pack years adult smoking proportion	0.4	0.5	1.3	-0.2	-0.8	1.1	0.8	-0.4
Impedance of leg (right)	0.3	1.7	5.4	-0.6	1.1	-0.4	2.3	-1.1
Leg fat-free mass (left)	0.5	2.6	4.4	-1.5	1.9	-1.4	0.8	-2.1
Trunk fat percentage	0.4	1.7	3.2	-1.1	1.3	0.3	1.8	-1.4
Hand grip strength (right)	0.5	1.2	2.2	-0.6	1.5	-1.5	-0.0	-1.2
Townsend deprivation index at recruitment	0.6	0.8	1.3	1.2	-1.0	1.0	0.1	0.8
Current tobacco smoking	1.3	2.2	3.1	-0.7	1.5	-1.8	1.4	-1.7
Average weekly fortified wine intake	0.2	0.2	0.4	0.6	-0.2	-0.6	-0.3	0.2
Maternal smoking around birth	0.9	1.3	2.4	0.5	-1.5	1.0	-1.0	1.4
Fed-up feelings	0.4	0.7	2.9	0.1	0.0	-1.7	0.9	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.4	0.3	-0.2	-1.6	0.6	-0.8
Relative age voice broke	0.3	0.5	1.5	-0.2	-0.0	-1.1	-1.2	0.2
Taking other prescription medications	0.9	1.3	4.7	0.1	-2.2	1.0	-0.4	0.8
Age when periods started (menarche)	0.1	0.3	1.1	0.1	1.1	0.3	-0.2	-0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.4	-0.3	-1.2	0.6	-0.5	0.7
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.5	7.6	-2.5	1.7	-2.8	1.4	-2.0
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.8	-0.9	0.6	0.3	0.8	-0.8
Qualifications: CSEs or equivalent	1.0	1.3	4.0	1.1	-1.0	-0.7	-2.0	0.2
Serious illness, injury or assault to yourself	1.6	1.9	2.7	1.6	-1.6	1.1	-0.9	1.6
High blood pressure	2.9	8.0	12.0	2.4	-2.7	3.5	-2.0	3.3
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.7	0.9	0.6	-0.4	0.7	-0.0
Multivitamins +/- minerals	0.3	0.3	0.5	0.7	-0.4	-0.3	-0.7	0.7
Stomach or abdominal pain in last month	0.6	0.7	1.9	0.5	-1.1	-0.2	-1.4	0.1
Supplements: Glucosamine	0.2	0.3	0.6	-0.8	0.2	-0.7	-0.1	-0.4
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	2.1	0.6	-1.3	1.4	0.3	1.1
Medication: Atenolol	0.8	0.9	2.8	0.6	-0.7	1.7	-0.5	1.0
Medication: Levothyroxine sodium	0.2	0.3	0.8	-0.3	-0.3	-0.8	-0.9	0.2
Sitting height	5.4	38.5	57.5	-5.6	5.9	-5.6	6.2	-7.6
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	-1.2	-0.4	1.1	0.6	0.1
High blood pressure (mother)	1.3	1.9	4.2	2.1	-0.8	1.6	1.2	0.6
Body mass index (BMI)	0.1	0.3	1.2	0.2	-0.3	0.3	-1.1	0.1
Impedance of leg (left)	0.3	1.3	5.6	0.4	0.3	0.8	2.4	-0.3
Leg predicted mass (left)	0.4	2.4	3.9	-1.4	1.9	-1.4	0.7	-2.0
Trunk fat mass	0.6	2.8	4.2	-1.5	1.9	-0.2	2.0	-2.1
Waist circumference	0.1	0.4	0.7	-0.6	0.8	-0.6	0.5	-0.8
Number of incorrect matches in round	1.9	3.1	4.5	1.9	-2.1	-0.0	-1.7	2.1
Past tobacco smoking	0.2	0.5	1.4	0.8	0.3	0.4	-1.2	-0.2
Alcohol usually taken with meals	0.4	0.7	1.6	-0.2	1.0	0.8	1.3	-0.4
Nervous feelings	0.2	0.4	1.1	-0.5	-0.5	-0.2	-1.0	0.4
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	4.0	1.6	-2.0	-0.5	-0.1	1.0
Hearing difficulty/problems with background noise	0.6	0.9	2.2	-1.3	-0.2	-0.5	1.5	-0.5
Hair/balding pattern: Pattern 2	0.5	0.6	1.6	0.1	-1.0	-0.8	-1.3	0.1
Had menopause	0.8	1.0	1.6	0.6	-0.7	1.3	1.0	1.2
Had other major operations	3.4	4.2	6.7	1.9	-2.6	1.9	-1.7	2.0
Forced vital capacity (FVC)	1.2	4.5	7.8	1.8	-2.5	0.4	-2.8	2.3
Heel bone mineral density (BMD) T-score, automated (right)	3.1	7.1	10.2	-2.7	2.7	-3.2	1.7	-2.7
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	0.2	0.0	-0.4	0.6	0.3
Qualifications: None of the above	0.3	0.6	1.5	-0.7	0.2	-1.2	0.7	-0.5
Financial difficulties in last 2 years	1.3	1.7	3.8	1.9	-1.9	0.8	0.0	0.5
Mouth/teeth dental problems	0.8	1.3	5.8	0.1	-0.6	-0.1	-2.4	0.5
Heart attack	0.1	0.1	0.2	-0.4	0.4	-0.0	-0.2	-0.3
Allergy	1.2	2.8	6.7	0.8	-2.0	0.9	-2.6	1.3
Pain all over the body in last month	1.1	1.2	2.8	1.1	-0.9	0.9	-0.6	1.7
Diabetes (self-reported)	1.4	2.2	3.4	1.6	-1.9	1.6	-1.0	1.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.4	-0.3	-0.1	-0.4	0.4
Medication: Ramipril	0.4	0.5	0.8	-0.9	0.4	0.9	0.8	-0.1
Medication: Simvastatin	1.6	2.4	3.7	1.4	-1.3	1.3	-1.6	1.9
Fluid intelligence score	0.6	1.2	3.0	-1.7	1.6	-0.5	-0.2	-0.4
Illnesses of siblings	0.8	1.2	1.9	-1.3	1.4	-0.6	0.3	-1.4
Neuroticism score	0.4	0.8	2.4	0.8	-1.5	-0.4	-0.4	0.7
Weight	0.4	1.9	3.6	-1.3	1.5	-1.1	0.8	-1.9
Impedance of arm (right)	0.3	1.5	4.7	0.4	-0.0	1.6	2.2	0.2
Arm fat percentage (right)	0.1	0.4	1.5	-0.1	0.4	1.2	0.5	-0.2
Trunk fat-free mass	0.8	4.8	7.5	-2.3	2.4	-2.2	1.0	-2.7
Hip circumference	0.2	0.7	1.5	-0.6	1.1	-0.5	0.6	-1.2
Time employed in main current job	0.6	0.6	1.5	-0.6	0.7	-0.2	0.9	-1.2
Alcohol intake versus 10 years previously	0.1	0.1	0.4	-0.3	0.5	0.0	-0.6	0.1
Father’s age at death	0.8	1.1	2.4	-1.6	1.2	-0.3	0.4	-1.3
Worrier / anxious feelings	0.9	1.7	3.0	1.0	-1.6	-0.0	-1.7	1.4
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.5	1.2	-0.4	-0.7	-0.1	0.0
Falls in the last year	3.4	4.6	7.1	2.7	-2.5	0.7	-1.6	2.6
Hair/balding pattern: Pattern 3	0.7	1.0	1.8	-1.2	1.3	-0.5	0.7	-1.0
Number of live births	0.3	0.5	1.0	-1.0	-0.0	-0.7	0.7	-0.7
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	8.5	1.5	-2.0	0.2	-2.9	1.8
Pulse rate	0.6	1.0	3.5	1.9	-0.8	0.6	-0.6	0.3
Happiness	0.1	0.1	0.3	-0.5	-0.5	-0.3	0.1	-0.1
Noisy workplace	0.4	0.5	1.3	0.3	0.5	-1.1	0.9	-0.6
Qualifications: A levels/AS levels or equivalent	1.3	2.8	6.9	-0.9	2.6	-0.5	1.9	-1.6
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.8	4.1	2.0	-1.5	0.9	-0.7	1.1
Mouth/teeth dental problems: Dentures	2.0	3.4	7.2	-2.0	1.3	-0.7	2.7	-1.9
Asthma	1.3	2.6	4.6	-2.2	0.8	-0.4	2.1	-1.8
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.4	4.5	1.2	-2.1	-0.6	-1.7	1.7
Medication: Cholesterol lowering	0.1	0.2	0.5	0.2	-0.2	0.5	0.2	0.7
Depression (self-reported)	0.8	1.0	3.2	1.8	-1.0	0.3	-0.5	0.6
Medication: Lansoprazole	0.1	0.1	0.5	-0.0	-0.1	0.1	0.7	-0.1
Prospective memory result	0.7	0.9	1.8	-0.6	1.2	-0.5	0.7	-1.4
Lung cancer (father)	0.3	0.3	0.6	-0.4	0.7	0.1	0.8	-0.6
Illnesses of mother	1.5	1.8	5.0	-1.4	1.0	-2.2	0.2	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	8.6	1.1	-1.6	0.2	-2.9	1.2
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	0.3	-0.7	-0.6	0.1	0.1
Impedance of arm (left)	0.2	0.9	3.4	0.2	0.2	0.9	1.9	0.2
Arm fat mass (right)	0.1	0.5	1.0	-0.6	0.9	0.1	0.6	-1.0
Trunk predicted mass	0.8	4.8	7.5	-2.3	2.3	-2.2	1.0	-2.7
Standing height	1.6	16.2	21.8	-3.6	4.1	-3.6	4.0	-4.7
Length of working week for main job	1.0	1.1	2.6	1.1	-0.5	1.6	-0.1	1.2
Exposure to tobacco smoke at home	0.3	0.3	0.9	0.2	-0.3	1.0	-0.1	0.6
Breastfed as a baby	1.5	1.8	3.1	1.2	-1.3	0.5	-1.6	1.7
Tense / ‘highly strung’	1.0	1.7	2.9	1.5	-1.7	0.5	-0.8	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	5.5	1.6	-2.3	1.3	-1.4	1.5
Hair/balding pattern: Pattern 4	0.1	0.3	0.6	0.7	-0.4	0.8	0.5	0.3
Birth weight of first child	0.4	0.7	1.3	-0.2	-0.7	1.1	-0.8	1.1
Peak expiratory flow (PEF)	0.1	0.3	0.9	0.5	-0.4	1.0	-0.3	-0.0
Pulse wave reflection index	1.3	1.7	3.7	1.1	-1.9	0.0	-1.3	1.4
Ever highly irritable/argumentative for 2 days	1.8	2.2	3.5	-1.6	0.9	-0.9	1.9	-1.9
Loud music exposure frequency	0.4	0.4	1.1	0.5	-0.7	1.1	-0.0	0.5
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	2.5	0.6	0.0	-0.3	-1.6	0.7
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	3.3	1.8	-0.3	1.5	1.6	0.4
Blood clot in the leg (DVT)	1.4	1.8	3.1	-1.7	1.4	-1.8	0.1	-1.0
Medication: Paracetamol	2.4	4.0	6.0	1.8	-2.4	0.9	-2.4	2.1
Headache pain in last month	0.8	1.4	2.6	1.6	-1.5	0.3	-1.1	0.9
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	3.2	-1.3	0.6	-1.2	0.3	-1.8
Glaucoma (self-reported)	1.4	1.7	3.3	1.3	-1.4	0.4	-1.2	1.8
Gout (self-reported)	1.1	1.4	3.7	0.7	-0.5	1.0	-1.9	1.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.6	-1.6	1.0	-0.6	0.6	-0.9
Medication: Amlodipine	0.1	0.2	0.4	0.6	0.1	0.6	0.3	0.3
Medication: Ventolin 100micrograms inhaler	1.5	2.0	3.5	-1.9	0.4	-0.5	1.7	-1.8
Birth weight	0.8	1.8	4.8	-1.2	1.1	-2.2	-1.1	-0.6
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.2	-0.9	1.1	-0.1	-0.0	-0.1
High blood pressure (siblings)	0.4	0.6	1.0	1.0	-1.0	0.4	-0.0	0.9
Forced vital capacity (FVC), Best measure	0.8	3.1	7.5	1.2	-1.9	0.3	-2.7	1.7
Body fat percentage	0.3	1.1	2.2	-0.8	1.1	0.4	1.5	-1.1
Leg fat percentage (right)	0.2	0.8	1.5	-0.8	1.0	0.3	1.2	-1.0
Arm fat-free mass (right)	0.7	3.3	5.0	-1.8	1.9	-2.0	0.7	-2.2
Exposure to tobacco smoke outside home	2.3	3.0	5.4	1.4	-2.3	0.1	-2.0	1.9
Comparative body size at age 10	0.5	1.5	4.2	-2.0	1.3	-0.9	-0.2	-0.8
Number of full brothers	0.3	0.4	1.4	1.2	-0.3	0.3	0.3	0.4
Worry too long after embarrassment	0.2	0.3	0.6	-0.1	-0.8	0.1	0.7	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	3.3	4.3	5.9	2.2	-2.3	1.5	-1.9	2.4
Wheeze or whistling in the chest in last year	5.1	9.1	14.9	-2.9	3.6	-0.4	3.9	-3.0
Number of children fathered	0.6	0.7	1.2	-0.8	0.9	0.6	1.1	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	2.8	1.7	-1.2	1.3	-0.9	1.2
Age at first live birth	0.6	1.0	4.3	-0.3	2.1	-0.3	0.4	-0.8
Pulse wave peak to peak time	0.4	0.5	1.4	-0.9	1.2	0.2	0.2	-0.6
Health satisfaction	1.2	1.6	2.7	-0.9	1.1	-1.4	1.1	-1.7
Shortness of breath walking on level ground	0.2	0.3	1.0	-1.0	-0.0	-0.1	0.2	-0.7
Qualifications: College or University degree	0.1	0.2	0.5	-0.7	0.4	0.0	-0.1	0.3
Eye problems/disorders: None of the above	2.6	3.0	5.9	0.6	-2.3	1.2	-2.4	1.4
Mouth/teeth dental problems: Loose teeth	2.4	2.8	4.8	-1.3	2.2	-1.4	1.7	-1.7
Emphysema/chronic bronchitis	0.3	0.3	0.9	-0.5	0.3	-0.3	1.0	0.3
Medication for pain relief, constipation, heartburn	3.2	5.6	9.1	-1.6	3.0	-0.7	3.0	-2.6
Neck or shoulder pain in last month	0.7	0.9	2.0	0.7	-1.4	-0.4	-1.0	1.1
Medication: Blood pressure	1.6	2.8	4.7	1.9	-0.8	2.2	-0.7	2.2
Angina (self-reported)	0.1	0.1	0.6	-0.8	-0.1	0.2	0.2	-0.1
Migraine (self-reported)	0.4	0.4	1.7	-0.5	0.1	-0.2	1.3	-0.5
Medication: Ibuprofen	1.5	1.8	2.7	1.1	-1.6	-0.8	-1.5	1.5
Medication: Allopurinol	0.5	0.7	2.8	-0.1	-0.4	0.3	-1.7	0.7
Medication: Omeprazole	1.7	2.0	4.8	0.6	-2.2	-0.8	-1.6	1.3
Medication: Seretide 50 evohaler	0.7	0.8	3.6	-0.0	-0.5	1.9	0.4	0.0
Mean time to correctly identify matches	0.6	1.2	2.4	-1.5	0.9	-1.5	-0.0	-0.8
Heart disease (mother)	0.5	0.6	1.1	0.7	-1.0	0.7	-0.5	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.3	-1.2	0.7	0.5	0.8	-1.0
Whole body fat mass	0.4	1.7	2.7	-1.1	1.5	-0.2	1.5	-1.6
Leg fat mass (right)	0.5	2.0	3.1	-1.3	1.8	-0.5	1.4	-1.7
Arm predicted mass (right)	0.6	3.3	5.2	-1.7	1.8	-2.1	0.8	-2.3
Pulse rate, automated reading	0.7	2.4	4.5	2.0	-1.2	2.1	-0.9	1.1
Alcohol intake frequency.	0.5	1.1	2.7	1.7	-1.3	0.6	-0.8	0.6
Comparative height size at age 10	0.4	2.3	3.7	-1.0	1.5	-1.8	1.1	-1.9
Number of full sisters	0.1	0.1	0.2	-0.1	-0.5	-0.4	-0.3	-0.1
Suffer from ‘nerves’	0.5	0.8	2.0	0.1	-1.4	0.8	-0.9	0.6
Overall health rating	0.6	1.4	2.2	1.5	-1.3	1.3	-0.8	0.8
Chest pain or discomfort	1.2	1.7	6.2	-0.2	0.2	1.4	2.5	-0.3
Had major operations	0.1	0.1	0.3	-0.5	0.0	-0.2	0.1	0.2
Age at last live birth	0.4	0.6	2.1	-0.6	1.4	-0.1	0.2	-0.6
Family relationship satisfaction	0.1	0.2	0.3	0.1	-0.5	-0.4	0.4	-0.5
Leg pain on walking	0.6	0.8	1.5	0.7	-1.2	-0.4	-0.7	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.9	0.4	-0.5	1.7	1.0	-0.6
Commuting to job workplace: Car/motor vehicle	3.0	3.5	6.3	-2.2	1.0	-2.0	1.1	-2.5
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.3	-1.3	0.7	-1.5	-0.2	-0.6
Medication: Aspirin	0.2	0.2	0.8	-0.3	-0.4	0.1	-0.9	0.2
Supplements: Vitamin C	0.2	0.2	0.7	0.1	-0.8	-0.0	-0.5	0.4
Knee pain experienced in last month	0.9	1.4	2.9	-1.1	-1.1	-1.7	-1.1	-0.6
Hypertension (Self-reported)	2.6	7.3	11.1	2.3	-2.5	3.3	-1.9	3.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.7	0.6	-0.7	0.5	0.1	0.8
Illnesses of father: Heart disease	1.2	1.7	2.4	1.5	-1.1	1.0	-1.3	1.6
Illnesses of siblings: Diabetes	0.5	0.6	1.7	1.3	-0.5	0.7	-0.3	0.7
Smoking status: Previous	0.5	0.8	2.1	-1.4	0.2	-0.6	1.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.9	-0.1	1.0	-0.7	0.8	-1.4
Whole body fat-free mass	0.6	3.4	5.4	-1.8	2.0	-1.8	0.9	-2.3
Leg fat-free mass (right)	0.2	0.9	1.7	-0.7	1.2	-0.7	0.5	-1.3
Arm fat percentage (left)	0.1	0.3	1.0	-0.0	0.5	1.0	0.4	-0.2
Average weekly red wine intake	1.4	2.1	3.9	0.4	-1.3	1.7	-1.3	2.0
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.9	0.0	-0.7	-1.2	-1.4	-0.1
Mood swings	0.3	0.6	1.6	1.1	-1.3	-0.4	-0.1	0.5
Loneliness, isolation	1.6	2.3	5.6	-0.7	1.2	-0.9	2.4	-1.7
Long-standing illness, disability or infirmity	0.4	0.6	1.6	0.3	-1.3	0.8	0.1	0.7
Ever had bowel cancer screening	0.7	0.8	2.4	-1.1	-0.0	0.1	1.5	-0.7
Diabetes diagnosed by doctor	0.7	1.2	1.9	1.1	-1.3	1.4	-0.2	0.9
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.4	4.0	1.7	-2.0	1.4	-0.7	1.7
Friendships satisfaction	0.2	0.3	1.0	-0.1	-1.0	0.2	-0.3	0.4
Qualifications: nursing, teaching	0.5	0.7	2.1	-0.7	1.0	0.5	1.4	-0.0
Commuting to job workplace: Walk	1.3	1.4	2.8	1.4	-0.8	1.7	-0.6	1.1
Eye problems/disorders: Cataract	3.0	3.5	6.1	-1.3	2.4	-0.4	2.5	-1.9
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.7	-0.3	0.8	0.2	1.3	0.1
Medication for cholesterol	2.2	3.3	7.0	-1.3	2.6	-0.9	2.2	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	2.8	0.4	-0.9	-0.6	-1.7	0.5
Back pain experienced in last month	3.8	5.6	10.2	-2.0	1.6	-3.2	1.8	-2.8
Mineral and other dietary supplements	0.2	0.3	0.6	-0.6	0.2	0.6	-0.4	-0.8
Breast cancer (self-reported)	4.2	5.0	7.3	2.1	-2.6	1.0	-2.4	2.7
Asthma (self-reported)	1.5	3.1	5.4	-2.3	0.9	-0.2	2.3	-1.9
Osteoporosis (self-reported)	0.6	0.7	1.2	-0.9	0.8	-1.1	-0.4	-0.9
Osteoarthritis (self-reported)	0.4	0.5	1.3	0.6	-1.1	0.2	-0.7	0.7
Medication: Aspirin	0.5	0.7	1.7	0.6	-0.8	0.4	-1.3	0.7
Medication: Gliclazide	6.1	6.9	10.3	2.8	-3.2	1.7	-2.1	3.0
Illnesses of father: None of the above (group 1)	2.0	2.4	4.3	-1.5	0.9	-1.0	2.0	-2.1
Smoking status: Current	1.1	1.8	2.8	-0.6	1.3	-1.7	1.2	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.3	13.4	15.7	3.7	-3.7	3.2	-4.0	3.7
Whole body water mass	0.5	3.0	4.8	-1.7	1.9	-1.8	0.8	-2.2
Leg predicted mass (right)	0.2	1.0	1.8	-0.8	1.3	-0.7	0.5	-1.4
Arm fat mass (left)	0.1	0.6	1.1	-0.5	1.1	0.2	0.7	-1.0
Number of self-reported non-cancer illnesses	1.0	1.6	3.3	0.8	-1.8	1.3	-1.0	1.3
Average weekly champagne plus white wine intake	0.8	1.0	1.7	-0.7	1.3	-0.2	1.3	-1.1
Miserableness	0.2	0.4	0.8	0.4	0.0	-0.9	0.8	-0.4
Guilty feelings	2.0	3.0	4.6	1.7	-2.1	0.9	-1.6	2.0
Wears glasses or contact lenses	1.4	1.6	3.3	-1.2	1.0	-0.5	1.8	-1.3
Ever taken oral contraceptive pill	0.3	0.4	1.0	0.2	0.4	1.0	0.8	0.0
Hearing aid user	0.2	0.3	0.8	-0.1	0.1	-0.9	0.6	-0.3
Mother’s age at death	0.8	1.0	1.6	-1.1	1.0	-0.5	1.3	-0.9
Financial situation satisfaction	1.9	2.3	4.1	2.0	-1.9	0.4	-1.0	1.5
Tinnitus: Yes, now most or all of the time	1.9	2.2	3.9	-1.2	2.0	-0.3	1.9	-1.5
Commuting to job workplace: Public transport	9.2	11.0	14.0	2.9	-2.8	3.7	-3.5	3.5
Eye problems/disorders: Glaucoma	2.1	2.5	4.2	1.7	-1.3	0.8	-1.7	2.0
Medication: Blood pressure	2.6	4.9	9.1	1.6	-3.0	2.0	-2.0	2.2
Pain type(s) experienced in last month: Hip pain	0.3	0.3	1.5	-0.4	-1.2	0.1	-0.2	-0.1
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.5	0.9	-0.1	-0.6	-0.2	1.2
High cholesterol (Self-reported)	0.8	1.4	3.0	0.9	-1.2	0.0	-1.7	1.4
Medication: Bendroflumethiazide	0.5	0.8	2.0	0.1	-1.4	0.2	-1.0	0.9
Medication: Paracetamol	1.9	2.9	4.8	1.8	-2.2	0.8	-1.8	1.6
Medication: Lisinopril	2.1	2.7	5.4	1.1	-1.8	-0.2	-2.3	1.8
Medication: Atorvastatin	0.4	0.5	1.6	0.2	-0.4	0.7	1.3	0.2
Illnesses of father: High blood pressure	2.1	2.6	5.6	2.4	-0.9	1.5	-0.9	1.9
Alcohol drinker status: Never	0.3	0.3	0.9	0.6	0.2	-0.3	0.5	-0.9
Ever smoked	0.1	0.3	1.1	-0.3	-0.3	-0.0	1.1	0.1
Basal metabolic rate	0.6	3.1	5.2	-1.7	2.0	-1.7	0.9	-2.3
Leg fat percentage (left)	0.2	0.6	1.5	0.0	0.3	1.2	1.1	-0.4
Arm fat-free mass (left)	0.6	3.3	5.6	-1.8	2.0	-1.8	0.8	-2.4
Number of operations (self-reported)	0.4	0.6	2.6	-0.3	-1.6	-0.0	-0.6	0.3
Average weekly beer plus cider intake	0.5	0.7	1.7	-0.0	-0.5	-1.3	-1.1	0.2
Irritability	0.8	1.4	2.8	0.9	-1.7	-0.5	-0.8	1.5
Risk taking	0.1	0.1	0.2	0.1	-0.3	0.4	-0.4	-0.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	-0.6	0.4	0.1	0.4	-0.3
Fractured/broken bones in last 5 years	3.3	4.3	4.8	2.2	-2.1	2.1	-1.8	2.0
Age started oral contraceptive pill	3.1	3.8	8.0	0.6	-2.1	1.8	-1.8	2.8
Diastolic blood pressure, automated reading	2.4	7.6	8.9	2.5	-2.8	2.8	-2.6	3.0
Ever depressed for a whole week	0.1	0.1	0.5	0.3	-0.1	0.4	0.7	-0.1
Unable to work because of sickness or disability	0.7	0.9	2.4	1.2	-0.4	-1.6	-0.6	0.4
Commuting to job workplace: Cycle	1.4	1.6	2.9	1.6	-1.0	0.7	-1.0	1.7
Myopia	3.5	5.0	11.1	2.3	-1.9	3.3	-0.2	2.3
Vascular/heart problems diagnosed by doctor	3.1	8.6	11.9	-2.5	3.0	-3.4	2.0	-3.3
Cholesterol lowering medication	2.1	3.1	4.6	1.5	-2.2	1.6	-1.6	1.9
Medication: Omeprazole (e.g. Zanprol)	2.6	3.1	6.3	1.3	-2.5	0.2	-1.9	2.0
Pain experienced in last month	0.4	0.6	2.3	-0.2	1.5	0.2	0.7	-0.4
Supplements: Calcium	0.2	0.2	0.9	-0.3	-0.4	-0.3	0.9	-0.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.5	0.0	-0.0	-0.4	-0.7	-0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.3	0.3	-0.1	-0.4	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	3.2	-1.6	1.3	-1.8	-0.0	-1.0
Heart disease (siblings)	1.0	1.2	2.2	0.8	-1.0	1.5	-0.3	1.5
Alcohol drinker status: Previous	0.4	0.4	1.3	1.1	-0.1	0.4	0.8	0.1
Pack years of smoking	0.3	0.4	0.8	-0.5	-0.9	0.9	0.4	-0.4
Impedance of whole body	0.3	1.6	6.7	-0.1	0.6	0.6	2.6	-0.6
Leg fat mass (left)	0.3	1.2	2.1	-0.8	1.3	0.2	1.4	-1.3
Arm predicted mass (left)	0.6	2.9	5.1	-1.6	1.8	-1.7	0.7	-2.2