Best TWAS P=1.18e-09 · Best GWAS P=2.16e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ARFGEF2 | 0.09 | 0.05 | lasso | 8 | 0.10 | 9.2e-13 | 6.5 | -5.4 | 5.5e-08 | -0.82 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Esophagus Mucosa | ZFAS1 | 0.15 | 0.01 | enet | 16 | 0.01 | 8.9e-02 | 5.4 | 5.7 | 1.1e-08 | 0.69 | 0.06 | 0.79 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | ZFAS1 | 0.07 | 0.03 | enet | 14 | 0.05 | 5.8e-05 | 5.5 | 5.5 | 5.0e-08 | 0.77 | 0.17 | 0.77 | FALSE |
| 4 | GTEx | Testis | ARFGEF2 | 0.20 | 0.20 | lasso | 7 | 0.24 | 5.4e-11 | 3.8 | -5.4 | 8.0e-08 | -0.91 | 0.02 | 0.98 | FALSE |
| 5 | METSIM | Adipose | ARFGEF2 | 0.04 | 0.03 | lasso | 12 | 0.02 | 9.8e-05 | 6.7 | -6.1 | 1.2e-09 | -0.98 | 0.02 | 0.98 | TRUE |
| 6 | NTR | Blood | SNORD12B | 0.03 | 0.05 | lasso | 8 | 0.05 | 1.9e-14 | 5.5 | -5.8 | 4.9e-09 | -0.96 | 0.06 | 0.94 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ARFGEF2 | 0.05 | 0.04 | lasso | 5 | 0.05 | 3.2e-06 | 6.5 | -5.8 | 6.4e-09 | -0.94 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C20orf199 | 0.05 | 0.06 | lasso | 4 | 0.06 | 1.0e-04 | 5.5 | 5.5 | 5.0e-08 | 0.92 | 0.01 | 0.95 | FALSE |