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chr20:61,522,825-62,912,463

Best TWAS P=2.18e-36 · Best GWAS P=1.87e-36 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ARFRP1	0.07	0.07	lasso	3	0.06	5.3e-08	12.3	-11.8	2.6e-32	-0.96	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	STMN3	0.07	0.02	lasso	4	0.05	2.8e-06	8.2	9.1	1.5e-19	0.71	0.04	0.96	FALSE
3	GTEx	Adipose Visceral Omentum	GMEB2	0.19	0.01	enet	21	0.02	5.2e-02	4.3	5.8	4.9e-09	0.33	0.14	0.11	FALSE
4	GTEx	Adrenal Gland	OPRL1	0.48	0.29	enet	21	0.22	1.5e-08	4.8	6.0	1.4e-09	0.02	0.98	0.00	TRUE
5	GTEx	Artery Aorta	OPRL1	0.27	0.19	lasso	4	0.17	1.4e-09	4.8	5.3	1.3e-07	-0.07	1.00	0.00	FALSE
6	GTEx	Artery Aorta	TCEA2	0.09	0.04	lasso	3	0.03	1.3e-02	4.8	-5.8	7.1e-09	-0.08	0.25	0.41	FALSE
7	GTEx	Brain Cerebellar Hemisphere	OPRL1	0.27	0.14	lasso	7	0.17	4.4e-05	4.8	5.4	7.9e-08	-0.04	0.09	0.14	FALSE
8	GTEx	Brain Cerebellar Hemisphere	STMN3	0.39	0.08	lasso	5	0.22	2.1e-06	7.9	8.9	5.0e-19	0.64	0.20	0.52	TRUE
9	GTEx	Brain Cerebellum	STMN3	0.33	0.12	lasso	10	0.20	1.8e-06	8.7	9.1	8.9e-20	0.65	0.05	0.94	FALSE
10	GTEx	Brain Cortex	STMN3	0.25	0.09	lasso	7	0.11	6.8e-04	8.1	7.5	6.1e-14	0.72	0.11	0.63	FALSE
11	GTEx	Breast Mammary Tissue	GMEB2	0.18	0.02	lasso	5	0.06	3.0e-04	8.6	7.0	2.2e-12	0.54	0.14	0.19	FALSE
12	GTEx	Breast Mammary Tissue (Female)	GMEB2	0.36	0.06	lasso	4	0.05	1.2e-02	7.9	6.3	3.8e-10	0.61	0.16	0.09	FALSE
13	GTEx	Cells Transformed fibroblasts	RGS19	0.37	0.28	lasso	8	0.29	3.2e-22	-4.9	5.7	1.5e-08	-0.02	1.00	0.00	FALSE
14	GTEx	Cells Transformed fibroblasts	CTD-3184A7.4	0.09	0.00	enet	28	0.00	1.4e-01	8.1	9.2	2.6e-20	0.49	0.02	0.86	FALSE
15	GTEx	Colon Sigmoid	RGS19	0.27	0.07	enet	33	0.09	3.8e-04	5.8	5.1	2.9e-07	0.09	0.52	0.02	FALSE
16	GTEx	Esophagus Mucosa	PRPF6	0.16	0.00	enet	8	0.00	9.6e-01	-5.4	7.0	2.7e-12	0.36	0.05	0.06	FALSE
17	GTEx	Esophagus Mucosa	RGS19	0.43	0.28	enet	17	0.34	7.9e-24	4.8	5.2	1.9e-07	0.00	1.00	0.00	FALSE
18	GTEx	Nerve Tibial	CTD-3184A7.4	0.11	0.00	lasso	5	0.02	2.6e-02	3.7	-5.3	1.1e-07	-0.15	0.06	0.11	FALSE
19	GTEx	Pancreas	OPRL1	0.39	0.27	lasso	5	0.32	6.9e-14	4.8	5.5	4.1e-08	-0.05	1.00	0.00	FALSE
20	GTEx	Pituitary	STMN3	0.43	0.00	enet	8	0.06	1.1e-02	2.9	6.4	1.8e-10	0.54	0.06	0.30	FALSE
21	GTEx	Skin Sun Exposed Lower leg	OPRL1	0.14	0.10	lasso	6	0.11	4.4e-09	-4.9	5.5	3.1e-08	-0.03	1.00	0.00	FALSE
22	GTEx	Skin Sun Exposed Lower leg	RGS19	0.42	0.26	lasso	6	0.33	4.6e-28	4.8	5.8	6.0e-09	-0.02	1.00	0.00	FALSE
23	GTEx	Testis	RTEL1	0.19	0.06	lasso	5	0.14	8.0e-07	8.1	6.4	2.0e-10	0.63	0.16	0.68	FALSE
24	GTEx	Thyroid	SLC2A4RG	0.12	0.06	lasso	5	0.04	2.4e-04	8.7	-8.7	5.1e-18	-0.73	0.17	0.78	FALSE
25	GTEx	Thyroid	RGS19	0.23	0.14	enet	11	0.19	3.3e-14	-4.9	5.4	8.2e-08	0.01	1.00	0.00	FALSE
26	GTEx	Whole Blood	OPRL1	0.09	0.06	enet	8	0.07	4.3e-07	-5.6	-6.0	1.6e-09	0.05	0.98	0.00	FALSE
27	GTEx	Whole Blood	STMN3	0.10	0.00	lasso	3	0.00	1.2e-01	6.2	-9.5	2.7e-21	-0.73	0.02	0.78	FALSE
28	METSIM	Adipose	DNAJC5	0.03	0.00	blup	201	0.01	2.0e-02	5.9	6.3	2.1e-10	0.59	0.08	0.44	FALSE
29	METSIM	Adipose	RTEL1	0.07	0.01	enet	15	0.03	9.2e-06	7.6	-7.8	5.1e-15	-0.44	0.08	0.90	TRUE
30	METSIM	Adipose	STMN3	0.20	0.08	enet	30	0.11	1.0e-16	7.0	-6.7	2.3e-11	-0.44	1.00	0.00	FALSE
31	METSIM	Adipose	TPD52L2	0.03	0.00	bslmm	207	0.02	1.5e-03	-5.6	-11.3	1.6e-29	-0.69	0.02	0.75	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	C20orf201	0.10	0.09	enet	9	0.10	9.9e-13	5.3	-5.7	1.4e-08	0.06	1.00	0.00	FALSE
33	YFS	Blood	LIME1	0.12	0.19	enet	15	0.19	5.3e-59	12.6	12.5	1.2e-35	0.98	0.01	0.99	FALSE
34	YFS	Blood	OPRL1	0.07	0.07	lasso	5	0.09	5.0e-27	4.8	-5.8	6.9e-09	0.07	1.00	0.00	FALSE
35	YFS	Blood	SLC2A4RG	0.03	0.02	lasso	11	0.02	4.2e-08	7.8	9.0	1.7e-19	0.59	0.73	0.27	TRUE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	C20orf201	0.03	0.01	lasso	4	0.01	2.3e-03	5.3	-5.2	2.3e-07	0.01	0.00	0.99	FALSE
37	The Cancer Genome Atlas	Colon Adenocarcinoma	RGS19	0.09	0.04	enet	4	0.04	2.8e-03	5.2	5.3	9.1e-08	-0.04	0.01	0.97	FALSE
38	The Cancer Genome Atlas	Esophageal Carcinoma	GMEB2	0.16	0.04	blup	64	0.05	1.0e-02	-3.2	-8.9	6.6e-19	-0.50	0.02	0.28	FALSE
39	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	STMN3	0.02	0.02	blup	43	0.02	1.7e-03	8.2	7.6	3.3e-14	0.63	0.01	0.90	FALSE
40	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TNFRSF6B	0.03	0.01	blup	44	0.02	7.1e-04	8.8	8.6	8.3e-18	0.75	0.05	0.82	FALSE
41	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LIME1	0.04	0.03	lasso	3	0.02	7.2e-04	7.8	6.1	1.0e-09	0.31	0.10	0.02	TRUE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC2A4RG	0.03	0.01	blup	48	0.02	2.4e-03	8.8	-8.4	3.3e-17	-0.69	0.06	0.51	FALSE
43	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LIME1	0.08	0.07	lasso	4	0.06	2.0e-04	5.9	-7.2	8.4e-13	-0.61	0.14	0.53	TRUE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	LIME1	0.02	0.03	blup	47	0.02	6.2e-03	8.1	9.9	3.6e-23	0.83	0.04	0.52	FALSE
45	The Cancer Genome Atlas	Lung Adenocarcinoma	TNFRSF6B	0.02	0.01	enet	7	0.01	6.9e-03	8.7	11.1	7.6e-29	0.92	0.02	0.88	FALSE
46	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RTEL1	0.05	0.04	blup	56	0.03	4.2e-03	10.7	11.2	3.2e-29	0.88	0.01	0.81	FALSE
47	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	STMN3	0.07	0.01	blup	41	0.05	4.2e-04	7.9	7.1	1.7e-12	0.57	0.01	0.92	TRUE
48	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TNFRSF6B	0.05	0.02	blup	44	0.03	2.9e-03	12.6	11.5	1.5e-30	0.93	0.01	0.74	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	ARFRP1	0.03	0.02	lasso	2	0.02	1.2e-03	12.3	-12.4	3.7e-35	-0.98	0.01	0.97	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	LIME1	0.04	0.05	blup	47	0.05	9.0e-06	12.5	12.0	2.9e-33	0.96	0.01	0.99	FALSE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	OPRL1	0.07	0.08	lasso	4	0.08	7.8e-09	5.3	5.3	1.0e-07	-0.06	0.00	1.00	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC2A4RG	0.05	0.01	blup	48	0.02	2.0e-03	12.6	-12.6	2.2e-36	-0.85	0.01	0.96	TRUE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZGPAT	0.05	0.06	lasso	3	0.06	5.5e-07	8.2	-9.3	1.3e-20	-0.83	0.05	0.95	FALSE
54	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LIME1	0.10	0.02	blup	47	0.04	1.5e-02	12.6	10.0	2.0e-23	0.90	0.01	0.64	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	ARFRP1	0.04	0.00	blup	51	0.00	1.3e-01	12.6	-10.3	9.4e-25	-0.82	0.01	0.60	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	LIME1	0.05	0.03	blup	47	0.04	3.9e-05	8.6	8.3	1.3e-16	0.80	0.05	0.94	FALSE