Hub : Genes

STON1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.4310 0.0580 0.0e+00 0.242 0.264 0.303 0.321 0.293 4.3e-29 4.7e-32 2.2e-37 5.5e-40 6.1e-36
2 GTEx Brain Cortex 0.4020 0.0890 1.3e-05 0.232 NA 0.208 NA 0.197 4.6e-07 NA 2.1e-06 NA 4.0e-06
3 GTEx Brain Nucleus accumbens basal ganglia 0.2310 0.0920 9.0e-03 0.015 NA 0.014 NA 0.060 1.3e-01 NA 1.4e-01 NA 1.0e-02
4 GTEx Brain Putamen basal ganglia 0.4600 0.1240 1.4e-03 0.144 NA 0.076 NA 0.138 2.8e-04 NA 7.4e-03 NA 3.8e-04
5 GTEx Colon Sigmoid 0.4610 0.0900 2.6e-06 0.161 NA 0.201 NA 0.241 2.6e-06 NA 1.2e-07 NA 4.7e-09
6 GTEx Esophagus Gastroesophageal Junction 0.4100 0.1100 1.3e-04 0.422 NA 0.357 NA 0.414 1.2e-16 NA 8.9e-14 NA 2.7e-16
7 GTEx Esophagus Mucosa 0.0860 0.0370 5.0e-03 0.139 NA 0.089 NA 0.128 1.4e-09 NA 1.5e-06 NA 6.9e-09
8 GTEx Esophagus Muscularis 0.5070 0.0730 5.0e-16 0.446 NA 0.395 NA 0.433 1.2e-29 NA 1.7e-25 NA 1.7e-28
9 GTEx Lung 0.1172 0.0476 3.4e-03 0.061 NA 0.022 NA -0.003 1.9e-05 NA 8.1e-03 NA 7.0e-01
10 GTEx Nerve Tibial 0.1872 0.0696 4.1e-03 0.095 NA 0.081 NA 0.079 3.2e-07 NA 2.4e-06 NA 3.2e-06
11 GTEx Whole Blood 0.0660 0.0270 5.6e-03 0.004 NA -0.003 NA 0.001 1.1e-01 NA 8.4e-01 NA 2.3e-01
12 METSIM Adipose 0.0592 0.0197 1.6e-04 0.003 0.033 0.008 0.033 0.006 8.8e-02 8.2e-06 1.9e-02 9.3e-06 3.1e-02
13 ROSMAP Brain Pre-frontal Cortex 0.4809 0.0496 0.0e+00 0.208 0.329 0.367 0.363 0.338 2.9e-26 1.6e-43 1.8e-49 7.0e-49 6.0e-45
14 YFS Blood 0.0882 0.0200 1.1e-12 0.016 0.048 0.041 0.048 0.044 4.3e-06 2.0e-15 1.8e-13 1.5e-15 3.4e-14
15 TCGA Breast Invasive Carcinoma 0.0597 0.0238 1.5e-05 0.019 0.033 0.025 NA 0.028 8.0e-05 1.9e-07 5.4e-06 NA 1.8e-06
16 TCGA Kidney Renal Clear Cell Carcinoma 0.0905 0.0452 1.1e-05 0.023 0.026 0.044 NA 0.054 1.1e-03 6.1e-04 8.8e-06 NA 1.0e-06
17 TCGA Pancreatic Adenocarcinoma 0.1500 0.0700 8.7e-03 0.034 0.049 0.042 NA 0.031 1.5e-02 4.2e-03 7.5e-03 NA 1.8e-02
18 TCGA Thyroid Carcinoma 0.1030 0.0410 1.7e-04 0.037 0.030 0.039 NA 0.047 1.5e-04 5.6e-04 9.4e-05 NA 2.2e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Bipolar Disorder (2018) 1.4 2.2 7.3 1.3 -0.5 1.2 -0.8 -2.6 -2.4 -2.4 -2.3 0.4 -0.8 -0.7 0.4 0.5 -0.7 -2.7 -0.6 -1.3 0.8
Bipolar Disorder or Schizophrenia 0.6 1.5 7.1 1.7 1.4 2.7 1.0 -0.3 0.8 0.8 0.8 -0.9 -0.1 -0.3 2.5 1.4 0.2 -0.7 0.7 0.9 1.4
Depressed Affect (Nagel 2018) 1.1 2.2 10.3 -1.9 -2.0 -2.4 -2.1 0.2 -0.5 -0.5 -0.6 1.5 0.4 -1.5 0.4 -2.1 0.2 -0.7 -1.1 -0.1 -3.2
Depression (Nagel 2018) 1.1 1.6 10.9 -1.3 -1.3 -0.8 -1.0 -0.3 -0.3 -0.3 -0.4 -0.2 -0.3 -0.9 -1.5 -2.8 -0.6 -1.1 -0.3 -0.6 -3.3
Intelligence (Savage-Jansen 2018) 0.5 1.6 4.0 2.0 1.9 1.6 1.9 1.1 0.5 0.5 0.7 -1.1 0.6 -0.5 -0.5 0.9 1.6 0.8 2.0 -1.8 0.3
Neuroticism (Nagel 2018) 1.2 2.9 8.9 -1.5 -2.7 -2.3 -3.0 -0.0 -1.2 -1.2 -1.4 2.9 0.4 -0.4 1.0 -1.9 0.6 -1.0 -2.3 0.6 -1.8
Schizophrenia (2018) 1.6 3.4 8.3 1.2 2.2 0.6 2.0 1.8 2.9 2.9 2.9 -1.5 0.3 0.2 2.8 1.4 0.8 1.3 1.4 2.1 1.1
Schizophrenia vs Biploar Disorder 2.2 2.9 7.5 -0.7 2.0 -0.9 2.3 1.9 2.0 2.0 2.1 -2.2 -1.1 0.9 1.2 -0.6 0.9 2.7 2.4 1.6 -0.9
Worry (Nagel 2018) 1.0 2.1 6.0 -0.8 -2.4 -0.9 -2.2 -0.6 -1.7 -1.7 -1.8 2.4 1.0 -0.1 0.8 -1.1 0.9 -0.7 -2.5 0.5 -0.1
Alzheimer’s Disease (in mother) 1.8 2.1 4.7 0.2 -2.1 -1.4 -1.4 -1.6 -2.2 -2.2 -2.2 1.4 0.5 -0.5 -0.3 0.1 -1.7 -1.1 -2.0 -0.2 1.4
Alzheimer’s Disease (in father) 1.7 1.9 8.0 1.6 1.3 1.1 1.1 1.9 1.3 1.3 1.4 -0.7 -0.6 1.5 2.8 1.0 1.4 0.6 1.6 1.1 0.1
Alzheimer’s Disease (including proxy) 0.6 0.8 3.8 0.7 -0.9 -0.6 -0.7 -0.4 -0.9 -0.9 -0.9 0.4 -0.8 1.4 1.9 -0.2 -1.3 -0.3 -0.7 0.7 0.5
Crohns Disease (2017) 1.1 2.3 9.6 2.2 0.6 1.6 1.4 -1.3 -1.7 -1.7 -1.5 -1.1 -0.8 1.6 -1.8 0.7 0.8 -2.0 0.6 -3.1 -0.0
Irritable Bowel Disease (IBD) 0.8 2.0 6.4 1.3 -0.3 0.8 1.1 -1.5 -2.1 -2.1 -1.9 -0.8 -0.8 1.9 -0.7 0.3 0.8 -2.1 0.9 -2.5 -0.3
Ulcerative Colitis (UC) 0.5 1.0 2.9 -0.0 -1.2 -0.1 0.0 -1.5 -1.6 -1.6 -1.5 -0.1 -0.8 1.0 0.1 -0.3 -0.2 -1.7 0.4 -0.9 -0.4
Major Depression (MDD) 1.4 1.7 6.5 1.0 0.8 -1.1 0.1 2.6 1.8 1.8 1.7 0.0 1.5 -0.9 0.5 1.3 0.7 1.9 0.4 0.4 1.0
Reaction Time 1.2 2.3 9.8 -2.5 -1.2 -2.1 -2.4 -0.1 0.5 0.5 0.2 0.9 0.3 -0.4 0.3 -2.3 -3.1 -0.1 -1.0 1.1 -2.1
Verbal and Numeric Reasoning (VNR) 0.8 1.8 4.9 2.2 2.2 1.9 2.2 1.2 0.9 0.9 1.1 -0.9 -0.3 0.2 -0.0 1.4 1.4 0.9 1.3 -0.4 1.6
Breast Cancer 0.7 1.7 4.8 2.2 1.0 1.9 1.5 -1.5 -0.2 -0.2 -0.1 -0.5 -2.2 -1.6 -1.8 0.9 -0.3 -0.9 0.4 0.2 1.8
Ovarian Cancer 2.1 2.8 8.9 -0.1 0.3 -0.0 -0.6 1.8 2.7 2.7 2.5 1.7 1.5 0.5 2.2 -0.2 0.7 1.6 -0.9 3.0 1.4
Prostate Cancer 1.2 1.7 7.0 0.1 1.4 0.1 0.3 1.9 2.6 2.6 2.6 0.0 -0.0 -0.1 1.6 0.2 0.5 0.8 0.6 0.9 0.0
Age at First Birth 1.1 1.7 5.5 1.4 0.9 1.0 0.6 -1.5 0.2 0.2 0.2 -0.6 -1.7 2.4 2.0 0.6 -2.0 0.8 1.2 0.2 2.1
Bipolar Disorder (2011) 0.4 0.4 4.1 0.5 0.3 -0.2 0.5 -0.2 0.0 -0.2 -0.2 -0.4 -0.6 -0.4 0.5 0.3 0.5 0.5 -0.2 0.8 2.0
Body Mass Index (BMI) (2010) 0.7 1.0 5.8 -1.3 -0.6 0.3 -0.7 -0.6 0.1 0.1 0.0 -0.8 -0.9 0.3 -0.5 -2.4 -1.0 -0.1 0.9 -0.1 -2.3
Coronary Artery Disease (CAD) 1.1 1.3 10.7 -0.5 -0.6 -0.8 -1.2 0.1 0.9 0.9 0.7 1.0 0.8 3.3 1.3 -0.8 -0.6 0.3 -1.3 1.0 0.2
Crohns Disease (2012) 1.2 1.9 7.4 2.7 1.3 1.8 1.9 -0.3 -0.7 -0.7 -0.5 -1.2 -0.3 2.1 -0.8 1.3 1.2 -1.0 0.8 -2.5 0.3
Mean Putamen Volume 0.5 0.6 2.7 -0.3 -0.7 -0.1 -0.7 -0.5 -0.8 -0.8 -0.8 -0.6 -1.6 1.4 -0.2 0.5 0.8 0.9 -0.6 0.0 -0.2
Fasting Glucose 1.0 1.2 5.7 -1.4 -0.5 -1.0 -0.0 -0.7 0.9 0.9 0.7 -0.3 -0.4 1.3 0.2 -1.7 -2.2 -0.4 -0.5 2.4 -0.1
HbA1C 0.5 0.6 2.4 0.7 0.6 0.7 0.8 0.5 0.4 0.4 0.4 -1.5 -0.5 1.0 -1.1 -0.1 -0.4 -0.1 0.1 1.2 1.3
HDL Cholesterol 0.9 1.6 3.9 1.4 1.6 1.5 1.6 1.4 1.2 1.2 1.3 0.2 -1.3 -0.8 2.0 1.2 0.5 0.7 0.8 1.1 1.6
LDL Cholesterol 0.7 1.1 2.3 0.6 1.2 1.4 -0.0 0.7 1.5 1.5 1.5 -0.3 0.7 0.8 0.1 0.9 -1.4 0.7 0.5 1.2 1.5
Lupus 1.1 1.7 5.8 -0.4 -1.9 -2.4 -1.8 -1.1 -1.8 -1.8 -1.8 1.5 1.0 0.2 0.6 -1.1 -0.0 -0.4 -1.4 -0.5 -0.6
Neuroticism (2016) 0.5 0.7 2.4 -1.5 -1.0 -1.2 -1.2 0.0 -0.3 -0.3 -0.3 0.5 0.6 -0.6 -0.1 -1.5 1.1 -0.0 -0.6 -0.1 -1.0
Primary Biliary Cirrhosis 0.4 0.6 3.4 0.4 0.1 1.3 -0.2 0.4 -0.4 -0.4 -0.4 0.3 -0.5 -0.5 1.8 0.8 1.3 -0.6 0.2 -1.0 -0.1
Rheumatoid Arthritis 1.0 1.4 3.9 -1.4 0.8 0.0 0.0 1.4 1.8 1.8 1.8 -0.6 -0.7 0.4 0.1 -0.9 0.3 2.0 1.3 1.8 -0.2
Schizophrenia (2014) 1.9 4.2 9.5 1.6 2.9 1.1 2.6 2.0 2.8 2.8 2.9 -1.9 -0.4 -0.1 3.1 1.4 1.7 1.3 1.8 2.0 1.3
Triglycerides 0.7 1.1 6.1 -1.2 0.0 -0.3 -1.2 -0.8 0.6 0.6 0.5 -0.0 0.6 -0.7 -2.5 -0.7 -1.9 -0.6 0.4 0.5 -1.9
Type 2 Diabetes (T2D) (2012) 1.3 1.4 5.2 1.0 1.6 1.8 1.8 -0.1 1.2 1.2 1.3 -1.1 0.7 2.3 -0.8 0.8 -0.7 0.4 1.6 -0.1 -0.2
Ulcerative Colitis 0.5 0.7 2.0 0.6 -0.1 0.6 1.0 -0.6 -1.2 -1.2 -1.0 -0.8 -0.6 0.7 -0.6 0.0 1.1 -1.2 0.8 -1.4 -0.4
Blood Eosinophil Count 0.1 0.9 4.2 -0.4 -0.2 -0.2 0.4 -0.4 -0.9 -0.9 -0.8 -0.9 -0.6 -0.9 -2.0 1.3 1.4 -0.4 -0.4 -1.6 -0.5
Blood Platelet Count 0.5 5.5 31.6 -2.4 -0.7 -1.4 0.0 -2.4 -2.5 -2.5 -2.3 -2.1 -0.3 -0.9 -5.6 -2.2 -1.0 -0.1 1.5 -3.1 -3.5
Blood Red Count 0.2 1.9 6.6 1.7 1.8 1.0 1.5 0.7 1.6 1.6 1.6 0.4 -0.5 -0.5 0.9 1.8 1.0 1.2 0.8 1.7 2.6
Blood White Count 0.6 4.3 19.9 -0.5 0.7 1.1 2.5 -1.3 -1.4 -1.4 -1.1 -3.5 0.8 -0.8 -4.5 -0.2 -0.2 -1.6 1.7 -4.2 -2.7
Heel T-Score 0.1 0.8 3.3 0.2 -0.2 -0.4 0.1 1.0 0.1 0.1 0.1 0.8 1.2 -0.0 -1.8 0.2 1.8 1.3 1.0 1.1 0.4
BMI 0.4 2.6 11.8 -2.5 -0.8 -1.6 -0.7 0.1 0.2 0.2 0.2 -0.7 -0.2 -2.5 -3.4 -2.8 -0.5 -0.5 -0.3 -0.2 -3.1
Height 0.2 3.3 22.4 2.8 1.9 1.1 1.5 0.3 -0.1 -0.1 0.1 -0.6 0.3 3.0 4.7 2.1 2.1 0.5 0.7 -1.4 -1.2
Waist Hip Ratio (WHR) 0.8 3.6 9.5 -0.3 -1.5 -2.1 -1.2 -1.3 -2.0 -2.0 -2.0 0.6 3.1 -2.5 -2.4 2.2 1.8 0.6 -1.9 -3.0 -0.3
Systolic Blood Pressure 0.2 0.9 3.3 -1.0 -0.4 -1.3 -0.7 0.3 -0.5 -0.5 -0.5 -0.0 0.5 1.8 1.3 -1.6 -0.3 -0.2 -0.0 -0.4 -1.8
Smoking Status 1.1 2.7 9.3 -0.6 2.4 0.3 2.5 1.4 1.3 1.3 1.5 -3.1 -1.6 -1.9 -0.0 -0.7 0.1 0.8 2.4 -0.7 -2.5
Allergy or Eczema 0.3 0.7 3.8 1.2 0.6 -0.5 0.2 -0.1 0.6 0.6 0.5 1.0 -0.0 -1.2 0.2 1.9 0.4 0.6 -0.7 0.8 1.1
Cardiovascular Disease 1.1 3.7 11.2 -2.5 -2.5 -2.1 -1.9 -1.2 -1.7 -1.7 -1.8 0.1 1.6 -0.2 -3.1 -3.3 -1.5 -0.4 -1.1 -1.3 -2.7
Hypothyroidism (self reported) 1.0 2.2 9.9 -1.3 -2.6 -1.4 -2.1 -0.5 -1.1 -1.1 -1.3 2.7 0.7 -0.3 -1.2 -0.6 -0.5 0.6 -3.1 -0.2 0.4
Respiratory disease 1.1 2.3 8.0 0.4 1.3 0.7 1.3 2.0 2.6 2.6 2.5 -1.4 -0.3 -0.3 -0.5 0.0 -0.0 1.5 0.8 2.8 1.3
Type 2 Diabetes (T2D) (2018) 0.3 0.5 2.5 -0.3 0.3 -0.4 -0.2 -0.2 0.8 0.8 0.7 -0.2 -0.1 -1.4 -1.6 0.3 -0.7 -0.5 0.5 0.5 -1.4
Lung FEV1/FVC ratio 1.3 6.4 25.4 0.3 -2.8 -1.2 -3.0 -3.3 -2.9 -2.9 -3.0 1.5 -1.4 -5.0 -3.4 -0.1 -1.4 -2.3 -3.2 -1.2 0.4
Lung FVC 2.3 11.7 45.0 0.6 3.6 2.2 3.0 3.2 5.2 5.2 5.1 -2.1 -1.4 -0.2 1.5 0.3 -0.1 3.6 3.4 6.7 4.1
Neuroticism 1.1 2.6 7.0 -2.1 -2.2 -2.6 -2.6 0.7 -0.5 -0.5 -0.7 2.2 0.6 0.0 1.1 -2.4 1.2 -0.2 -1.9 0.3 -2.4
Chronotype (morning person) 4.8 11.0 30.2 -3.4 -5.4 -2.7 -5.5 -3.8 -4.1 -4.1 -4.4 4.1 0.1 1.3 0.2 -3.9 -0.7 -0.5 -4.0 0.7 0.4
Hair Pigment 0.0 1.3 3.3 1.0 1.8 1.1 1.5 1.0 1.4 1.4 1.5 -0.2 0.1 -0.4 0.6 0.5 1.7 0.6 1.0 1.6 -0.1
Tanning 0.0 0.3 2.8 -0.3 -0.1 -0.4 -0.3 -0.1 -0.6 -0.6 -0.6 0.0 -0.3 0.9 1.7 -0.5 0.2 0.4 -0.0 -0.0 -0.2
Hand grip strength (left) 1.0 2.7 10.7 0.4 1.7 0.0 1.3 1.3 2.4 2.4 2.4 -0.9 -0.8 2.6 1.8 -0.3 -0.9 0.5 1.0 3.3 1.2
Number of treatments/medications taken 0.6 1.1 4.2 -1.7 -1.7 -1.6 -1.4 0.6 0.6 0.6 0.4 0.8 -0.3 0.1 -0.0 -2.0 -0.4 0.7 -0.5 1.5 -0.7
Average weekly spirits intake 1.0 1.2 3.3 -0.2 0.6 0.7 0.9 1.2 1.0 1.0 1.0 -0.8 1.4 -0.2 -0.1 -1.3 1.3 1.8 1.5 0.9 -1.8
Sensitivity / hurt feelings 2.3 3.9 14.5 -1.0 -2.5 -2.2 -3.5 -0.2 -0.8 -0.8 -1.1 3.7 -1.0 -0.3 1.6 -1.3 -1.1 -0.9 -3.8 2.3 1.2
Frequency of depressed mood in last 2 weeks 0.9 1.2 7.5 -1.2 -0.6 -1.2 -0.5 0.3 0.2 0.2 0.1 0.0 0.3 -0.5 -1.3 -2.6 -0.7 -1.0 -0.8 -0.7 -2.7
Hearing difficulty/problems: Yes 0.3 0.5 3.7 -0.2 -0.0 1.1 -0.3 -0.5 0.4 0.4 0.4 -0.9 0.1 -0.8 -1.9 -0.3 -0.6 0.4 -0.5 -0.4 -0.5
Relative age of first facial hair 0.6 1.3 5.6 -0.7 -1.3 -0.9 -0.8 -1.5 -1.1 -1.1 -1.2 1.3 -0.7 -0.3 -2.4 -1.6 -1.1 -0.4 -1.1 -0.1 -0.7
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 4.9 -2.1 -2.2 -2.2 -2.2 -0.7 -0.5 -0.5 -0.6 1.6 -0.6 -2.1 -0.6 -1.8 -0.0 0.8 -1.6 1.9 -0.4
Ever used hormone-replacement therapy (HRT) 1.7 2.2 14.8 -0.6 -0.1 -0.7 0.1 2.1 0.2 0.2 0.2 -0.7 2.1 -3.8 -0.9 0.3 2.2 0.6 1.0 0.1 -2.6
Ever had hysterectomy (womb removed) 5.1 5.8 33.4 -2.3 -2.0 -1.5 -1.3 -2.5 -2.4 -2.4 -2.5 0.1 0.3 -3.4 -5.8 -2.4 -1.7 -1.8 -1.7 -1.7 -1.8
Systolic blood pressure, automated reading 0.3 1.0 3.9 -1.2 -0.6 -1.3 -0.4 -0.2 -0.8 -0.8 -0.8 0.2 -0.4 1.5 1.5 -1.8 -0.3 -0.4 -0.4 -0.2 -2.0
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 2.1 0.2 0.4 -0.3 0.1 1.0 1.0 1.0 1.0 0.7 -0.2 -1.3 0.3 0.1 0.5 0.5 -0.1 1.5 0.7
Angina 1.2 1.6 4.1 -1.5 -0.0 -2.0 0.2 1.6 1.2 1.2 1.1 -1.5 1.2 -1.7 -1.7 -0.9 0.4 1.3 0.4 0.5 -1.8
Medication for hormone replacement therapy 2.4 2.7 13.5 0.0 1.7 -0.3 1.9 2.2 1.1 1.1 1.2 -2.5 0.5 -0.8 0.2 -0.0 2.2 0.8 2.5 -1.0 -3.7
Vitamin and mineral supplements 1.3 1.8 16.2 0.9 0.8 0.2 1.3 0.5 -0.5 -0.5 -0.4 -1.4 0.5 4.0 0.5 0.8 -0.3 -0.3 0.8 -2.5 -0.8
Supplements: Zinc 1.3 1.4 3.3 -1.6 -1.8 0.3 -1.7 -1.2 -1.3 -1.3 -1.4 1.4 0.1 1.1 -0.4 -1.1 -1.4 -0.8 -1.2 0.2 0.1
Medication: Co-codamol 0.9 1.0 3.8 -0.6 0.2 -0.4 0.1 1.7 1.5 1.5 1.4 0.1 2.0 0.5 1.1 0.0 -0.2 0.5 1.1 0.9 -0.6
Medication: Metformin 0.4 0.6 2.8 -0.2 -0.2 -1.7 -0.1 0.5 1.0 1.0 0.9 0.6 0.5 0.2 -0.6 -0.0 0.1 0.6 0.9 1.6 0.1
Diabetes (father) 1.4 1.7 5.4 0.3 1.6 0.8 0.6 1.9 2.3 2.3 2.3 0.7 1.3 -1.1 0.5 0.9 0.3 0.5 0.7 1.5 -0.1
Diabetes (mother) 0.9 1.2 2.5 -0.7 -0.2 0.3 0.7 -0.8 -1.2 -1.2 -1.2 -1.1 -1.4 1.5 -1.5 -0.2 -1.4 -0.9 -0.2 -1.6 -1.3
Severe depression (siblings) 0.7 0.8 6.6 0.8 0.6 0.1 1.2 1.0 0.5 0.5 0.6 -0.6 0.1 -0.9 0.7 2.6 1.2 0.5 0.2 0.5 0.0
Pack years adult smoking proportion 0.4 0.7 3.3 0.4 -0.1 0.2 0.1 -0.1 0.4 0.4 0.5 -0.8 0.5 -0.7 -1.6 -0.7 -1.1 -0.4 -0.3 -1.4 -1.8
Impedance of leg (right) 0.4 2.0 6.7 -0.6 -0.9 -1.4 -1.2 -0.6 -1.7 -1.7 -1.6 2.6 2.5 0.1 2.2 1.0 1.4 -0.4 -0.9 -0.7 0.1
Leg fat-free mass (left) 0.3 1.5 4.8 0.3 1.1 0.5 1.1 1.0 1.7 1.7 1.6 -1.9 -0.4 -0.1 -1.8 -1.3 -0.6 -0.3 1.0 0.2 -2.2
Trunk fat percentage 0.5 1.8 12.6 -1.9 0.1 -1.9 0.2 1.6 0.3 0.3 0.4 -0.1 1.8 -0.2 -1.0 -1.1 1.9 -0.5 -0.6 -0.8 -3.5
Hand grip strength (right) 1.4 3.8 9.4 1.1 2.4 0.8 1.8 1.6 2.8 2.8 2.8 -1.3 -0.6 3.0 2.2 0.1 -1.5 0.6 1.3 3.1 1.8
Townsend deprivation index at recruitment 1.1 1.6 7.2 -1.7 0.1 -1.2 0.5 0.5 -0.2 -0.2 -0.1 -1.9 0.0 -1.3 -1.5 -1.9 -0.2 1.3 1.4 -1.3 -2.7
Current tobacco smoking 0.8 1.3 6.2 -0.7 0.9 -0.3 1.1 0.1 -0.4 -0.4 -0.2 -1.4 -1.1 -2.5 -1.6 0.1 0.6 0.5 0.7 -2.0 -2.0
Average weekly fortified wine intake 1.2 1.4 5.1 1.2 1.1 0.4 0.7 1.4 1.2 1.2 1.2 -1.3 0.1 -1.1 -1.9 0.2 0.8 2.3 0.8 0.9 0.8
Maternal smoking around birth 0.8 1.1 8.7 -1.4 -0.4 -1.5 0.2 0.6 -0.2 -0.2 -0.2 -1.4 0.6 -1.1 -0.6 -1.5 0.1 -0.3 0.3 -0.2 -2.9
Fed-up feelings 1.4 2.5 13.9 -2.0 -2.0 -1.9 -1.8 -0.4 -1.3 -1.3 -1.3 0.6 0.4 -0.5 -0.1 -2.6 -0.9 -1.3 -0.8 -1.1 -3.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 5.6 -0.4 -1.0 -1.0 -1.0 0.7 -0.2 -0.2 -0.2 -0.1 0.4 -1.3 -1.6 -1.6 -0.3 -0.3 -0.4 -0.9 -2.4
Relative age voice broke 0.1 0.2 0.6 0.3 -0.0 -0.1 -0.1 0.6 0.6 0.6 0.5 0.8 -0.4 -0.1 -0.2 0.4 0.2 0.2 -0.4 0.7 0.5
Taking other prescription medications 0.8 1.2 4.5 -1.0 -2.1 -0.8 -1.7 0.6 -0.2 -0.2 -0.3 1.8 0.7 0.6 -0.8 -1.3 0.5 0.1 -1.9 1.2 0.2
Age when periods started (menarche) 0.8 2.0 13.5 1.6 -0.5 -2.1 -1.1 -0.8 0.2 0.2 0.1 1.3 -0.5 1.7 1.9 0.3 0.8 0.6 -2.0 0.8 3.7
Bilateral oophorectomy (both ovaries removed) 4.7 5.4 12.1 -1.9 -2.7 -2.7 -3.0 -3.1 -2.8 -2.8 -2.9 0.3 -1.0 -2.2 -3.5 -2.4 -1.8 -0.0 -1.7 -0.3 -2.3
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 5.3 -0.8 -0.5 0.0 0.4 -0.7 -0.7 -0.7 -0.7 -0.5 0.3 -0.5 -2.3 -1.3 -0.3 -0.4 0.8 -0.7 -0.4
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 4.3 1.0 0.0 0.4 -0.6 -0.8 -0.4 -0.4 -0.4 -0.0 -2.1 0.1 0.8 0.3 0.1 -0.1 0.1 -0.2 -0.2
Qualifications: CSEs or equivalent 0.7 0.9 4.5 -1.8 -0.3 -0.6 -0.3 0.6 0.6 0.6 0.6 0.1 1.4 -0.1 -2.1 -1.7 0.2 0.9 -0.2 0.8 -0.8
Serious illness, injury or assault to yourself 0.3 0.4 1.8 0.5 0.5 0.9 -0.1 0.3 0.3 0.3 0.3 0.2 0.9 -0.4 -1.0 1.3 -0.1 -0.3 -0.7 -0.2 1.0
High blood pressure 0.4 1.1 9.0 -1.1 -0.7 -1.2 -1.0 0.0 -0.4 -0.4 -0.5 -0.3 0.2 -0.8 -1.1 -1.3 -0.7 -0.6 -0.1 -0.9 -3.0
Hayfever, allergic rhinitis or eczema 0.2 0.4 3.1 1.0 0.4 -0.1 0.2 -0.5 0.0 0.0 0.0 0.5 -0.3 -0.8 -0.1 1.8 -0.3 0.7 -0.2 0.6 1.0
Multivitamins +/- minerals 1.4 1.7 15.4 -0.8 -0.5 0.0 -1.5 0.3 0.8 0.8 0.7 1.9 0.0 -3.9 0.1 -0.2 1.1 0.5 -0.7 2.2 0.2
Stomach or abdominal pain in last month 1.6 1.9 11.0 -0.0 0.7 1.1 1.0 -0.7 0.5 0.5 0.6 -2.5 -1.1 -2.5 -3.3 -1.0 -1.5 -0.3 1.8 0.4 -0.0
Supplements: Glucosamine 0.9 1.2 6.6 -0.0 -0.8 -0.7 -1.6 0.6 0.0 0.0 -0.1 1.7 -0.1 -0.8 0.5 0.2 0.2 1.2 -0.8 2.6 2.1
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 2.3 -1.1 -1.5 -0.3 -0.6 -1.0 -0.7 -0.7 -0.7 0.3 -0.4 -0.9 -1.4 -1.0 -0.7 -1.2 -1.1 0.8 0.3
Medication: Atenolol 0.5 0.7 1.9 0.1 0.7 0.8 0.3 0.7 1.3 1.3 1.2 -0.6 0.7 -1.4 -0.5 0.5 0.3 -0.5 0.7 0.3 -1.1
Medication: Levothyroxine sodium 1.0 1.8 5.1 -1.5 -2.3 -1.7 -1.5 -0.9 -1.1 -1.1 -1.2 2.0 1.1 0.5 -0.8 -2.0 -0.5 -0.2 -1.9 -0.4 -0.6
Sitting height 0.2 1.4 4.9 1.8 2.0 1.1 2.2 -0.6 0.8 0.8 0.9 -1.2 1.1 0.0 -0.8 1.1 0.1 -0.9 1.2 -1.3 -0.9
Chronic bronchitis/emphysema (father) 0.7 0.9 3.3 -1.1 -1.5 -1.8 -1.5 0.2 -0.5 -0.5 -0.6 1.2 1.0 -0.9 0.5 -0.1 0.0 0.1 -1.1 0.5 -0.9
High blood pressure (mother) 1.0 1.4 5.8 -2.0 -1.7 -1.0 -0.3 -1.4 -1.0 -1.0 -1.0 0.1 -0.4 2.0 -0.6 -2.4 -0.5 -0.4 -0.2 0.4 -1.5
Body mass index (BMI) 0.4 1.5 9.2 -1.9 -0.3 -0.7 -0.3 0.6 0.5 0.5 0.4 -0.9 0.2 -0.8 -2.5 -2.1 -0.3 -0.7 0.0 -0.4 -3.0
Impedance of leg (left) 0.3 1.7 4.2 -0.4 -0.4 -0.7 -0.7 -0.8 -1.7 -1.7 -1.6 1.9 2.1 0.4 1.9 1.4 1.7 -0.8 -0.8 -1.4 -0.3
Leg predicted mass (left) 0.3 1.4 4.8 0.2 1.0 0.4 1.0 0.9 1.6 1.6 1.5 -1.8 -0.4 -0.2 -1.9 -1.4 -0.7 -0.3 0.9 0.2 -2.2
Trunk fat mass 0.4 1.8 15.0 -1.7 0.3 -1.5 0.3 1.3 0.6 0.6 0.6 -0.6 1.2 -0.1 -1.5 -1.6 1.2 -0.6 -0.1 -0.6 -3.9
Waist circumference 0.4 1.3 7.4 -1.6 -0.8 -2.0 -1.1 0.5 0.3 0.3 0.2 0.2 1.3 -0.9 -1.5 -1.0 0.6 0.1 -0.8 -0.3 -2.7
Number of incorrect matches in round 0.2 0.3 2.4 0.2 0.2 -0.2 -0.4 0.2 0.4 0.4 0.4 -0.3 1.5 -0.5 0.5 0.4 -0.0 0.8 0.5 0.0 -1.1
Past tobacco smoking 1.0 1.8 3.9 1.1 -1.6 0.7 -1.4 -1.7 -1.8 -1.8 -1.8 1.9 0.1 1.2 0.3 1.0 0.3 -0.3 -1.7 -1.1 2.0
Alcohol usually taken with meals 0.4 0.6 4.7 0.6 -0.2 -0.1 -0.7 -0.5 0.4 0.4 0.2 1.4 -0.1 -0.5 1.3 0.4 -0.4 -0.3 -0.3 0.8 2.2
Nervous feelings 0.7 1.4 5.7 -0.1 -1.8 -1.1 -1.3 -0.1 -1.2 -1.2 -1.2 2.3 1.4 0.2 -0.1 0.2 1.0 -0.2 -2.4 -0.1 0.6
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 8.0 0.5 0.1 -0.6 0.1 1.0 0.5 0.5 0.5 -0.3 1.0 -2.8 -0.8 -0.2 1.3 -1.0 -0.0 -1.3 -2.2
Hearing difficulty/problems with background noise 0.3 0.5 1.1 0.6 -0.8 0.9 -0.7 -1.0 -0.7 -0.7 -0.7 -0.1 -0.5 1.1 -0.8 -0.8 -0.4 -0.4 -0.4 -0.5 -0.7
Hair/balding pattern: Pattern 2 0.8 1.0 3.7 -1.4 0.5 0.4 0.3 0.4 1.4 1.4 1.3 -0.4 -0.1 -0.6 -0.2 -1.3 -1.0 -0.3 1.1 1.9 -1.0
Had menopause 0.3 0.3 2.7 0.3 0.1 1.0 -0.2 0.9 -0.1 -0.1 -0.1 -0.2 -0.3 -0.3 1.6 0.3 0.8 0.2 -0.3 -0.1 -0.5
Had other major operations 1.7 2.1 8.3 -0.9 -1.3 -0.5 -1.4 -2.1 -1.2 -1.2 -1.2 -0.0 -0.8 -2.7 -2.9 -1.1 -2.3 -1.0 -1.1 -0.2 0.2
Forced vital capacity (FVC) 1.4 5.5 11.3 1.2 3.4 1.6 3.3 2.5 3.1 3.1 3.2 -1.7 0.9 0.6 1.2 1.4 1.3 2.6 3.0 3.0 1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 4.7 -1.0 -0.8 -0.1 0.0 -0.9 -1.0 -1.0 -0.9 -0.8 0.8 -1.1 -2.2 -1.1 -0.8 -0.5 0.9 -0.8 -0.7
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 3.5 -0.3 -1.3 0.0 -0.7 -0.7 -0.7 -0.7 -0.7 0.9 -0.9 -1.5 -0.7 -0.5 -1.2 0.3 -1.9 0.1 1.3
Qualifications: None of the above 1.1 2.3 6.7 -2.5 -2.6 -2.2 -1.9 -0.4 -1.4 -1.4 -1.5 0.3 0.3 2.0 0.7 -1.3 -0.2 1.8 -0.7 1.6 0.5
Financial difficulties in last 2 years 1.0 1.3 4.3 0.7 1.6 1.0 2.0 0.8 0.2 0.2 0.4 -1.4 -0.0 -0.6 -1.9 0.9 0.1 -0.5 0.2 -2.1 -1.8
Mouth/teeth dental problems 0.9 1.4 5.2 1.7 1.4 1.0 1.4 -0.4 -0.8 -0.8 -0.6 -1.1 -2.3 1.5 0.6 1.6 -0.4 -0.1 0.8 -1.1 1.2
Heart attack 0.6 0.7 2.4 -1.3 -0.1 -0.9 0.0 -0.0 0.3 0.3 0.3 -1.2 -0.5 -1.1 -1.5 -1.6 -0.5 0.2 0.9 0.7 -1.0
Allergy 0.4 1.0 4.7 -0.2 -0.4 0.2 -0.0 -0.9 -1.2 -1.2 -1.2 -0.0 0.4 1.4 -0.1 -1.0 -0.6 -2.0 -0.0 -2.2 -0.9
Pain all over the body in last month 0.8 0.9 5.4 -1.0 -0.9 -0.6 -0.3 1.1 0.8 0.8 0.7 -0.1 1.2 -0.8 -1.2 -0.2 0.2 1.0 0.3 2.3 0.7
Diabetes (self-reported) 0.2 0.3 1.2 0.2 -0.2 0.1 -0.4 -0.4 0.8 0.8 0.7 0.5 -0.5 -1.1 -0.8 0.4 -0.5 -0.5 -0.2 0.9 0.1
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 3.6 1.9 1.6 1.4 1.3 1.1 1.3 1.3 1.3 -0.1 -0.3 -0.9 0.0 1.4 1.6 0.5 0.4 0.6 0.6
Medication: Ramipril 0.5 0.6 2.0 -0.7 0.8 1.4 0.3 0.6 1.1 1.1 1.1 -0.7 0.7 -0.9 -0.4 -0.3 -0.7 -0.1 0.2 0.6 -1.2
Medication: Simvastatin 1.7 2.6 11.3 -1.4 -1.6 -0.8 -1.3 -1.6 -0.7 -0.7 -0.8 -0.8 -0.4 -0.1 -3.2 -3.4 -2.1 -1.1 -0.6 -0.9 -2.6
Fluid intelligence score 0.6 1.1 5.8 2.0 1.1 1.9 1.4 0.5 0.5 0.5 0.6 -0.4 -0.3 -0.6 -0.3 1.3 0.6 0.7 0.4 -0.2 2.4
Illnesses of siblings 0.3 0.4 2.6 0.2 0.1 -0.7 0.3 -0.0 -0.5 -0.5 -0.4 0.1 -0.1 -0.1 1.6 0.8 0.5 0.5 -0.7 -0.5 1.5
Neuroticism score 1.5 3.2 9.4 -1.8 -2.4 -3.0 -3.1 0.9 -0.1 -0.1 -0.4 2.8 0.7 0.0 1.3 -2.4 0.8 -0.2 -2.6 1.0 -2.0
Weight 0.3 1.4 12.3 -0.8 0.5 -0.4 0.4 0.8 0.9 0.9 0.9 -1.0 0.4 -0.1 -1.7 -1.8 0.1 -1.0 0.5 -0.4 -3.5
Impedance of arm (right) 0.6 2.7 13.7 -0.1 0.2 -2.4 0.4 1.5 -0.4 -0.4 -0.2 2.0 2.4 -0.7 2.5 2.2 3.7 1.6 -1.3 -0.3 0.7
Arm fat percentage (right) 0.5 1.9 10.0 -2.2 -0.1 -1.9 -0.2 1.6 0.8 0.8 0.8 -0.2 1.4 -1.3 -1.7 -1.5 1.3 -0.1 -0.3 -0.1 -3.2
Trunk fat-free mass 0.2 1.1 2.8 0.7 0.8 1.1 0.7 -0.0 1.4 1.4 1.3 -1.7 -0.8 0.8 -1.1 -1.1 -1.4 -0.5 0.9 0.5 -1.4
Hip circumference 0.3 1.2 6.7 -0.7 0.5 -0.6 0.3 1.4 1.6 1.6 1.5 -0.1 0.1 0.3 -0.2 -1.9 0.3 -0.6 0.2 0.7 -2.6
Time employed in main current job 0.9 1.0 7.2 1.4 0.8 -0.4 0.2 0.1 0.6 0.6 0.6 0.7 -0.4 0.5 2.7 0.8 -0.3 0.5 0.3 1.4 1.9
Alcohol intake versus 10 years previously 0.4 0.5 2.8 -0.3 -0.8 -0.6 -0.4 -0.3 -0.5 -0.5 -0.4 0.7 0.8 0.0 -0.3 0.4 0.3 -0.8 0.1 -1.7 -1.6
Father’s age at death 0.8 1.1 6.7 1.4 0.5 0.5 0.5 0.9 0.7 0.7 0.7 -0.9 -0.1 2.6 1.7 0.2 1.0 1.0 0.9 -0.7 0.9
Worrier / anxious feelings 2.1 3.9 11.7 -1.4 -2.6 -2.5 -3.2 0.5 -1.6 -1.6 -1.7 3.4 1.1 1.5 3.1 -1.0 0.6 0.5 -2.9 1.0 1.2
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 6.6 -0.5 0.2 -0.3 0.2 1.2 0.8 0.8 0.8 -0.6 -0.0 -0.5 -0.8 -1.5 0.1 -0.2 1.0 0.0 -2.6
Falls in the last year 0.4 0.5 3.5 -0.5 -1.4 -0.3 -0.8 0.2 -0.3 -0.3 -0.3 0.0 -0.1 -1.9 -0.4 -1.1 0.2 -0.3 -0.4 0.5 -0.1
Hair/balding pattern: Pattern 3 0.4 0.6 4.0 0.2 -0.1 0.3 -0.6 0.5 0.6 0.6 0.5 -0.3 -1.4 0.3 2.0 -0.0 0.2 0.7 -0.9 1.3 0.5
Number of live births 0.6 0.8 7.1 0.5 -0.3 -0.1 -0.7 0.5 -0.0 -0.0 -0.1 -0.6 -0.2 -2.7 -1.2 -0.5 0.2 -1.7 -0.2 0.6 -0.7
Forced expiratory volume in 1-second (FEV1) 0.6 2.0 5.5 0.7 2.1 1.1 2.0 1.0 1.8 1.8 1.8 -1.1 0.2 -0.4 -0.2 0.8 0.3 1.5 1.8 2.3 1.3
Pulse rate 1.2 2.1 8.4 -0.1 -1.3 0.8 -1.5 -1.2 -0.9 -0.9 -1.0 0.5 -2.5 -1.8 -2.9 -0.5 -1.7 0.8 -0.7 1.6 1.8
Happiness 3.2 3.8 21.0 -2.0 -2.2 -2.5 -2.3 -0.4 -0.6 -0.6 -0.7 1.0 -0.3 -4.6 -2.7 -3.4 -0.8 0.6 -1.9 0.5 -1.1
Noisy workplace 2.4 2.9 11.0 -2.7 -2.2 -3.3 -2.2 -0.5 -1.5 -1.5 -1.6 0.5 0.7 -0.1 -2.2 -2.4 -1.2 1.8 -0.9 -0.2 -1.1
Qualifications: A levels/AS levels or equivalent 1.3 2.9 13.0 3.6 1.9 3.3 1.8 0.2 -0.4 -0.4 -0.2 -0.6 -0.4 0.3 -0.2 3.3 0.6 -1.5 1.1 -2.0 1.1
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.8 0.5 0.1 0.6 0.9 -0.6 -0.6 -0.6 -0.5 -0.0 0.1 0.4 -0.8 0.1 0.8 -0.7 0.1 -0.6 0.3
Mouth/teeth dental problems: Dentures 0.7 1.2 5.6 -1.4 -1.3 -1.1 -1.3 -0.2 1.0 1.0 0.8 0.3 0.1 -0.8 -0.2 -2.4 -0.2 0.0 -0.8 2.2 -0.4
Asthma 0.7 1.3 4.7 0.4 0.4 0.6 0.8 1.5 1.8 1.8 1.7 -0.7 -0.6 -1.2 -0.3 -0.5 0.0 1.1 0.4 2.2 1.1
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 3.8 0.7 -0.6 0.3 -0.6 1.4 0.5 0.5 0.4 1.6 1.9 -0.6 1.4 0.5 1.2 0.2 -0.9 0.2 1.4
Medication: Cholesterol lowering 0.9 1.4 5.3 -1.7 -1.9 -1.6 -2.0 -0.6 -0.3 -0.3 -0.5 0.3 -0.2 0.2 -1.2 -2.3 -1.5 0.0 -1.3 0.8 -0.1
Depression (self-reported) 0.5 0.6 4.2 0.3 -0.4 -1.1 0.0 -0.1 -0.3 -0.3 -0.3 0.2 0.6 -1.1 -2.0 -0.3 0.2 -0.5 -1.3 -1.2 -0.6
Medication: Lansoprazole 0.2 0.2 1.8 0.1 0.5 0.8 0.7 0.3 -0.0 -0.0 0.1 -0.1 0.5 0.2 -0.1 0.2 -0.2 0.2 1.3 0.3 -0.4
Prospective memory result 0.9 1.0 5.9 -0.9 -1.4 -1.0 -1.5 0.6 0.5 0.5 0.3 1.4 2.4 0.2 1.3 -0.2 0.2 0.5 -1.0 1.1 -0.3
Lung cancer (father) 0.5 0.6 3.6 0.6 -0.2 0.8 0.5 -0.1 -0.5 -0.5 -0.4 -1.0 -1.1 -0.4 -1.9 0.4 0.1 -0.4 -0.2 -1.5 0.0
Illnesses of mother 2.5 3.1 10.5 1.6 2.5 0.8 1.2 3.2 2.4 2.4 2.4 -1.8 1.8 -1.3 -0.4 1.6 1.8 0.9 1.2 -0.7 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.3 8.2 0.7 2.4 1.0 2.1 2.1 2.8 2.8 2.7 -1.3 0.4 -0.5 0.0 0.7 0.7 1.7 2.3 2.9 1.1
Pulse wave Arterial Stiffness index 0.7 0.8 6.6 -0.7 0.3 -1.3 -0.4 -0.9 -0.2 -0.2 -0.1 -1.1 -1.0 -0.9 -2.6 -0.1 -0.4 0.1 0.3 -0.2 -1.3
Impedance of arm (left) 0.5 2.5 13.8 0.5 0.8 -1.6 0.7 1.5 -0.7 -0.7 -0.5 1.7 1.9 -0.5 2.8 2.6 3.7 1.2 -0.8 -0.7 0.7
Arm fat mass (right) 0.4 1.6 11.0 -1.6 0.3 -0.9 0.3 1.2 0.9 0.9 0.8 -0.9 1.1 -0.8 -2.2 -1.7 0.6 -0.5 0.2 -0.3 -3.3
Trunk predicted mass 0.2 1.1 2.5 0.6 0.7 1.1 0.6 -0.0 1.4 1.4 1.3 -1.6 -0.8 0.7 -1.2 -1.1 -1.4 -0.5 0.8 0.5 -1.4
Standing height 0.1 1.3 3.9 1.9 2.0 0.6 1.8 0.5 1.1 1.1 1.1 -0.8 0.4 1.4 1.1 0.6 0.9 -0.3 1.2 -0.3 -1.4
Length of working week for main job 0.4 0.4 2.3 -0.6 -0.5 -0.2 0.3 0.4 -0.7 -0.7 -0.7 -0.0 0.6 -0.5 -0.1 -0.3 0.7 -0.5 0.1 -1.2 -1.5
Exposure to tobacco smoke at home 0.8 0.9 6.7 -1.1 -0.5 -0.1 0.7 -0.2 -0.5 -0.5 -0.4 -0.7 1.7 -2.6 -1.0 0.4 1.0 0.0 0.4 -1.2 -0.6
Breastfed as a baby 0.7 0.9 7.5 -0.2 -0.7 -0.1 -1.1 -0.3 0.1 0.1 -0.0 1.3 -0.9 -0.8 0.1 -1.4 -0.7 -0.5 0.5 2.7 0.8
Tense / ‘highly strung’ 0.4 0.6 2.2 -0.3 -0.6 -0.3 -0.9 0.8 -0.2 -0.2 -0.2 0.8 1.4 -0.1 1.3 0.4 1.5 -0.5 0.1 -0.7 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 1.5 0.6 -0.3 -0.1 -0.2 0.9 0.1 0.1 0.1 0.0 1.0 -0.3 0.7 0.5 0.5 -0.9 -0.6 -0.5 -1.2
Hair/balding pattern: Pattern 4 1.2 3.0 16.5 2.1 -0.0 1.3 1.2 -0.4 -2.0 -2.0 -1.8 -0.7 1.1 -0.1 -1.5 2.3 2.6 -0.3 0.1 -4.1 1.4
Birth weight of first child 0.6 1.2 9.4 0.2 0.0 -0.8 -0.1 0.3 1.2 1.2 1.1 -0.3 -1.0 -0.2 -0.8 -1.1 -0.6 0.7 0.4 3.1 1.7
Peak expiratory flow (PEF) 1.0 2.4 8.6 0.9 2.0 0.8 1.8 1.3 2.0 2.0 2.0 -0.4 0.1 -0.3 -0.5 1.4 -0.2 1.4 0.4 2.9 2.7
Pulse wave reflection index 0.6 0.8 2.7 0.5 1.4 -0.7 1.0 0.4 0.6 0.6 0.8 -1.6 -0.0 1.1 0.7 0.3 0.7 1.1 1.1 -0.5 -0.6
Ever highly irritable/argumentative for 2 days 1.0 1.2 4.3 -0.6 0.6 -1.2 0.4 0.2 1.1 1.1 1.1 -1.8 -2.1 -0.9 -0.5 -1.9 -0.7 0.5 0.1 0.5 -1.4
Loud music exposure frequency 1.1 1.2 4.4 0.9 0.4 1.0 1.4 0.3 -0.4 -0.4 -0.2 -0.9 -1.6 -2.1 -0.4 0.9 1.2 1.3 0.2 0.6 2.1
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 2.0 1.0 0.5 1.4 0.8 0.4 0.5 0.5 0.4 0.1 -0.5 0.2 -0.3 0.7 0.0 -1.2 -0.5 -0.3 -0.0
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 5.2 -1.0 -0.9 -0.9 -0.8 -0.6 0.3 0.3 0.1 1.4 2.3 -0.8 -1.4 -0.8 -1.4 -0.6 -0.6 0.7 -0.3
Blood clot in the leg (DVT) 0.8 1.0 3.3 -1.1 -0.8 -0.2 -1.1 1.3 1.4 1.4 1.3 0.1 -0.3 -0.4 0.1 -1.2 0.2 1.4 -0.5 1.8 -0.6
Medication: Paracetamol 1.2 2.0 7.1 -0.6 -0.8 0.4 -1.4 1.8 1.8 1.8 1.6 2.7 1.1 0.2 2.3 -0.5 0.5 0.5 -0.7 2.4 0.3
Headache pain in last month 2.4 4.2 11.4 2.2 1.4 0.2 0.9 3.4 2.1 2.1 2.2 0.8 1.1 -1.8 2.2 2.9 3.4 2.0 1.1 1.1 2.5
Medication for cholesterol, blood pressure or diabetes 1.0 1.6 4.7 1.5 1.3 1.9 1.8 -0.5 -0.7 -0.7 -0.5 -1.2 -0.2 0.2 0.7 1.8 1.0 -0.6 2.0 -2.2 -0.7
Glaucoma (self-reported) 1.3 1.5 7.1 2.7 1.1 1.1 1.7 0.7 0.2 0.2 0.3 -0.2 0.3 0.2 0.0 2.2 2.6 -0.3 0.4 -1.5 0.1
Gout (self-reported) 0.5 0.7 4.3 -0.7 0.3 0.9 0.6 0.5 -0.4 -0.4 -0.2 -0.1 0.8 0.3 0.2 -0.8 2.1 -1.0 -0.1 -1.4 -1.3
Hypothyroidism/myxoedema (self-reported) 1.2 2.3 7.8 -1.1 -2.7 -1.6 -2.1 -1.0 -1.4 -1.4 -1.6 2.8 0.7 0.5 -0.7 -1.4 -0.4 -0.2 -2.7 -0.2 0.3
Medication: Amlodipine 1.0 1.4 6.6 0.4 1.4 -0.7 0.7 2.6 1.4 1.4 1.4 -0.0 1.4 1.0 0.7 1.5 1.4 1.3 0.4 -0.0 -1.0
Medication: Ventolin 100micrograms inhaler 0.3 0.4 2.0 0.3 -0.8 -0.2 -0.3 0.6 -0.2 -0.2 -0.2 0.4 0.3 -1.3 0.1 -1.4 0.1 -0.6 -0.8 0.4 -0.1
Birth weight 1.2 2.7 7.4 -0.7 -0.8 0.4 -0.3 -1.8 -2.7 -2.7 -2.6 -0.0 -1.2 0.9 -1.6 -1.5 0.5 -2.3 -0.7 -1.7 -2.5
Chronic bronchitis/emphysema (mother) 1.5 1.8 6.0 -1.5 -2.0 -1.8 -2.4 -0.5 -0.6 -0.6 -0.7 2.4 0.4 -1.3 1.2 -0.4 0.2 0.3 -2.0 0.8 1.0
High blood pressure (siblings) 0.8 1.1 3.0 0.3 1.2 1.6 0.6 -0.1 1.2 1.2 1.1 -1.4 -1.7 0.3 -0.8 -0.7 -0.8 -0.4 0.9 0.8 -1.7
Forced vital capacity (FVC), Best measure 1.7 6.3 14.4 1.3 3.5 1.6 3.1 3.0 3.8 3.8 3.8 -1.8 0.5 -0.1 1.0 1.2 1.4 2.2 3.2 3.3 1.4
Body fat percentage 0.5 2.1 15.0 -2.3 -0.2 -2.1 -0.5 1.3 0.2 0.2 0.2 0.1 1.8 -0.7 -1.3 -1.5 1.4 -0.7 -0.5 -0.7 -3.9
Leg fat percentage (right) 0.8 3.1 20.2 -2.9 -1.4 -1.9 -1.9 0.2 -0.9 -0.9 -0.9 0.8 1.6 -0.6 -1.5 -2.3 0.4 -1.3 -0.5 -1.0 -4.5
Arm fat-free mass (right) 0.3 1.5 4.0 0.6 1.0 1.5 0.8 -0.1 1.2 1.2 1.2 -1.9 -0.8 1.2 -1.6 -1.4 -1.4 -1.2 1.2 -0.1 -2.0
Exposure to tobacco smoke outside home 0.6 0.8 6.4 -0.3 1.1 -0.0 1.0 0.2 0.8 0.8 0.9 -1.1 0.0 -2.5 -0.3 0.6 0.8 0.9 0.4 -0.3 -0.5
Comparative body size at age 10 0.3 1.0 5.4 -1.7 -0.8 -1.1 -0.3 0.0 0.2 0.2 0.1 -0.2 -2.3 0.1 -1.8 -1.5 -0.8 0.5 -0.4 0.6 -0.4
Number of full brothers 1.0 1.2 4.5 -0.2 1.3 0.8 1.4 0.5 1.4 1.4 1.5 -1.7 -0.6 -0.9 -0.6 -1.0 0.3 0.2 2.1 1.1 0.0
Worry too long after embarrassment 1.8 3.0 10.1 -1.3 -1.0 -1.7 -1.9 2.3 1.6 1.6 1.3 3.2 0.9 0.6 1.9 -1.2 1.4 0.7 -2.4 2.8 -0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.5 7.4 1.9 0.3 0.2 -0.1 -0.1 -0.4 -0.4 -0.3 -0.7 -0.1 -2.0 -1.0 -0.0 -0.9 -2.7 -0.2 -2.1 -2.0
Wheeze or whistling in the chest in last year 0.4 0.6 3.5 -0.8 -0.5 0.7 -0.7 -0.3 -0.5 -0.5 -0.5 0.2 -0.5 -0.5 -0.1 -1.8 0.4 -0.6 -0.8 -0.0 -1.9
Number of children fathered 1.8 2.0 7.3 0.9 1.5 0.4 1.7 2.1 1.2 1.2 1.3 -1.2 0.5 2.2 2.7 1.4 1.8 0.2 0.8 -0.1 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 5.3 0.5 2.0 0.1 1.9 1.5 1.0 1.0 1.1 -1.3 1.5 -0.3 -0.4 2.3 0.3 1.7 1.2 0.1 -0.3
Age at first live birth 0.8 1.4 5.6 1.2 -0.4 -0.2 -0.7 -0.6 -0.5 -0.5 -0.6 2.0 -1.0 0.9 2.3 1.8 0.4 0.4 -1.2 -0.1 2.4
Pulse wave peak to peak time 0.9 1.0 7.8 0.7 -0.3 1.3 0.4 1.1 0.4 0.4 0.3 1.1 1.2 1.0 2.8 0.2 0.5 -0.1 -0.3 0.4 1.4
Health satisfaction 1.9 2.5 7.6 -2.8 -2.4 -1.4 -1.4 -0.5 -1.6 -1.6 -1.6 0.6 -0.2 -2.7 -2.0 -2.2 0.2 0.7 -0.5 -0.3 -1.6
Shortness of breath walking on level ground 1.1 1.3 4.6 -0.8 0.8 0.1 0.9 -0.6 0.8 0.8 0.9 -1.6 -1.4 -0.9 -1.5 -2.1 -1.4 -0.4 1.2 -0.4 -1.4
Qualifications: College or University degree 1.6 5.1 27.0 5.2 2.9 4.1 2.1 0.5 0.9 0.9 1.0 -0.6 -0.2 -2.5 0.5 3.3 1.0 -1.8 0.9 -1.4 2.6
Eye problems/disorders: None of the above 0.7 0.8 4.2 -2.0 -0.3 -1.2 -0.4 -0.3 -0.7 -0.7 -0.6 -0.1 -0.2 -0.0 1.9 0.5 0.3 1.9 0.0 0.3 -0.5
Mouth/teeth dental problems: Loose teeth 0.5 0.6 2.1 -0.4 0.8 -0.2 0.6 -0.5 -0.7 -0.7 -0.5 -0.6 0.7 -1.4 -1.0 1.1 -0.2 1.0 1.0 -0.6 -0.2
Emphysema/chronic bronchitis 1.7 1.9 6.4 -0.7 1.6 -0.2 0.4 1.4 2.1 2.1 2.1 -1.4 -0.9 0.5 1.0 -0.4 0.0 2.0 0.9 2.5 -0.1
Medication for pain relief, constipation, heartburn 1.6 2.7 15.2 0.9 1.1 0.6 1.1 -2.6 -2.1 -2.1 -1.8 -2.2 -3.9 -0.0 -0.5 0.9 -0.7 -0.3 0.7 -2.2 -0.4
Neck or shoulder pain in last month 0.4 0.5 3.4 -0.8 -0.4 -0.3 -0.3 -0.0 -0.0 -0.0 -0.1 -0.9 0.4 -0.7 0.4 -0.7 0.0 -1.8 -0.4 -0.7 -1.5
Medication: Blood pressure 0.5 0.9 3.4 -1.1 -0.1 -1.3 -0.9 1.1 1.1 1.1 0.9 0.7 0.4 -1.2 -0.2 -0.8 -0.5 0.6 -1.1 1.8 -0.1
Angina (self-reported) 1.3 1.7 4.8 -1.6 0.1 -2.2 0.2 1.6 1.4 1.3 1.2 -1.4 1.2 -1.5 -1.7 -1.0 0.4 1.3 0.5 0.7 -1.8
Migraine (self-reported) 1.1 1.4 5.5 0.6 -0.2 0.2 -0.5 1.5 1.0 1.0 0.9 1.3 2.4 -0.4 1.4 1.9 1.6 0.7 -0.9 1.2 1.2
Medication: Ibuprofen 0.6 0.7 2.1 0.1 -1.2 -0.2 -0.8 0.8 -0.4 -0.4 -0.4 1.4 1.0 -0.6 1.4 -0.2 1.5 -0.2 -0.8 -0.3 0.9
Medication: Allopurinol 0.6 0.8 2.7 -0.6 -0.1 1.2 0.7 0.4 -0.4 -0.4 -0.3 0.6 1.5 1.0 0.5 -1.2 1.6 -0.8 -0.5 -1.4 -1.0
Medication: Omeprazole 1.0 1.2 6.7 -0.1 0.3 -0.7 0.1 1.5 1.5 1.5 1.5 0.5 2.6 -0.0 1.3 0.4 0.5 1.1 0.2 1.2 1.0
Medication: Seretide 50 evohaler 0.6 0.7 2.9 -1.0 -1.1 -0.5 -0.5 -0.3 -0.7 -0.7 -0.7 -0.2 -0.4 -0.4 -0.2 -1.0 -1.3 -1.1 -0.6 -0.9 -1.7
Mean time to correctly identify matches 0.5 1.0 3.5 -1.4 -0.1 -1.5 -0.9 0.8 0.8 0.8 0.7 0.5 0.0 0.1 1.2 -1.1 -1.7 0.8 -0.1 0.7 -1.9
Heart disease (mother) 0.5 0.6 2.8 -0.3 -0.9 -0.5 -0.8 -1.2 -0.9 -0.9 -0.9 1.7 0.1 -0.6 0.0 -0.5 -0.0 -0.9 -0.5 -0.3 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.2 2.6 8.3 -0.6 -2.0 -1.4 -2.1 -1.2 -1.6 -1.6 -1.8 2.9 -0.4 -1.1 -0.6 0.5 -1.2 -0.3 -2.5 1.2 2.4
Whole body fat mass 0.5 2.0 16.6 -1.9 -0.0 -1.6 -0.1 0.9 0.4 0.4 0.4 -0.6 1.2 -0.6 -2.0 -2.0 0.6 -0.9 -0.1 -0.7 -4.1
Leg fat mass (right) 0.7 2.6 20.1 -2.5 -0.8 -1.5 -1.1 0.1 -0.2 -0.2 -0.3 -0.1 1.1 -0.9 -2.2 -2.6 -0.1 -1.6 -0.1 -0.8 -4.5
Arm predicted mass (right) 0.3 1.5 4.3 0.5 1.0 1.4 0.8 -0.0 1.2 1.2 1.1 -2.1 -0.7 1.0 -1.7 -1.2 -1.5 -1.0 1.2 0.0 -2.0
Pulse rate, automated reading 1.4 4.5 11.3 0.0 -2.6 -0.5 -2.6 -2.4 -2.5 -2.5 -2.6 2.0 -1.2 -2.2 -3.4 0.1 -2.0 0.5 -3.1 0.7 2.6
Alcohol intake frequency. 0.6 1.4 5.2 -0.4 -1.8 -1.6 -0.6 -1.0 -0.6 -0.6 -0.7 1.8 -0.3 -0.6 -1.5 -0.6 -0.3 -0.4 -2.1 0.8 2.3
Comparative height size at age 10 0.1 0.5 1.8 -0.3 0.2 0.5 0.4 -0.0 -0.5 -0.5 -0.5 -1.0 -1.4 1.3 -0.6 -1.0 -0.2 -0.3 0.3 0.5 -1.2
Number of full sisters 1.5 1.9 5.6 -2.4 -0.8 -1.0 -1.4 1.7 0.5 0.5 0.4 1.0 1.9 -2.3 -0.1 -0.6 1.6 1.7 -0.7 0.7 -2.0
Suffer from ‘nerves’ 0.6 0.9 3.8 -0.6 -1.5 -0.2 -0.7 0.0 -0.4 -0.4 -0.5 1.7 1.6 -0.2 0.3 -0.7 0.5 -0.3 -1.9 1.1 1.0
Overall health rating 1.3 2.7 15.1 -2.6 -1.3 -1.9 -1.3 0.7 -0.3 -0.3 -0.3 0.8 1.0 -2.3 -2.2 -2.4 0.7 0.2 -0.5 0.0 -3.9
Chest pain or discomfort 1.0 1.4 9.1 -1.3 -0.3 0.1 0.4 1.2 0.1 0.1 0.2 -0.7 1.5 -1.7 -1.2 -0.9 1.9 0.5 0.2 -0.8 -3.0
Had major operations 0.9 1.0 5.2 -0.1 -2.3 -1.9 -1.1 -0.3 -1.1 -1.1 -1.1 1.5 0.6 -0.3 0.2 0.0 0.3 -0.7 -1.0 0.5 0.3
Age at last live birth 0.7 1.0 5.1 0.4 -0.7 -0.5 -1.2 -0.2 -0.7 -0.7 -0.7 1.7 -1.7 -0.1 2.3 1.1 1.0 0.1 -0.8 0.5 1.0
Family relationship satisfaction 4.6 5.6 27.1 -2.9 -3.2 -2.4 -3.7 -0.8 -0.8 -0.8 -1.0 3.0 1.2 -5.2 -1.1 -2.6 -1.0 0.7 -3.0 1.7 -1.0
Leg pain on walking 1.7 2.1 13.2 -2.3 -2.1 -1.9 -1.7 -0.8 -1.0 -1.0 -1.2 0.5 -0.2 -0.3 -0.8 -3.6 -0.9 0.4 -1.1 0.3 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 0.9 0.2 1.0 0.4 0.1 0.7 0.8 0.8 0.9 -0.2 -0.8 -0.3 -0.1 -0.5 0.1 0.1 -0.1 0.9 -0.2
Commuting to job workplace: Car/motor vehicle 0.5 0.6 4.5 0.0 0.0 -0.4 -0.1 0.9 1.1 1.1 1.0 0.2 -0.1 -0.0 2.1 0.0 0.4 -0.2 -0.5 1.1 -0.0
Illness, injury, bereavement, stress in last 2 years 2.2 2.7 6.9 -1.9 -2.6 -1.8 -2.5 -1.9 -1.6 -1.6 -1.8 1.7 -0.2 -0.3 0.7 -2.4 -1.6 -0.2 -1.7 1.5 0.7
Medication: Aspirin 0.6 0.8 3.9 -2.0 -1.1 -1.0 -0.3 1.0 0.4 0.4 0.3 0.4 1.3 -0.1 -1.0 -1.3 -0.0 0.3 0.6 1.3 -0.9
Supplements: Vitamin C 0.8 0.9 3.2 0.2 0.5 1.1 0.3 -0.1 1.2 1.2 1.1 -0.2 0.8 -1.8 -1.3 0.8 -0.6 -0.4 0.2 1.5 1.1
Knee pain experienced in last month 0.9 1.4 5.5 -1.5 -0.8 -1.3 -0.7 1.5 1.0 1.0 0.9 -0.4 -0.0 0.9 1.3 -1.8 0.3 1.5 0.5 2.3 -0.5
Hypertension (Self-reported) 0.6 1.7 10.9 -1.6 -1.2 -1.5 -1.4 -0.7 -1.0 -1.0 -1.1 -0.0 -0.0 -0.3 -1.3 -2.0 -1.0 -0.8 -0.3 -1.2 -3.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 3.5 -1.4 0.2 -1.1 0.4 0.8 1.1 1.1 1.0 -0.5 1.9 1.3 0.8 -0.3 0.2 0.4 -0.0 0.2 -0.9
Illnesses of father: Heart disease 0.5 0.7 2.0 -0.5 -0.8 -0.5 -0.8 0.2 -0.8 -0.8 -0.8 1.1 1.2 -1.4 -0.7 -0.3 1.0 -1.4 -0.3 -0.1 -0.8
Illnesses of siblings: Diabetes 0.6 0.8 2.2 -1.3 -0.9 -0.8 -1.2 0.8 0.0 0.0 -0.0 1.5 1.5 -0.4 -1.0 -0.5 0.3 1.3 -0.0 0.6 -0.9
Smoking status: Previous 1.0 1.5 3.3 -1.2 1.2 -0.7 1.1 1.7 1.8 1.8 1.8 -1.2 0.6 0.2 1.1 -0.6 -0.2 0.4 1.5 1.2 -1.5
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.5 1.5 0.0 0.9 -0.6 1.2 0.2 0.6 0.6 0.6 -0.8 0.4 1.2 -0.9 -0.3 0.1 0.9 0.1 -0.6 -1.0
Whole body fat-free mass 0.2 1.4 4.0 0.6 1.0 1.1 0.9 0.3 1.5 1.5 1.4 -2.0 -0.7 0.5 -1.6 -1.2 -1.3 -0.7 0.9 0.1 -1.9
Leg fat-free mass (right) 0.3 1.9 5.1 0.6 1.5 1.0 1.5 1.0 1.9 1.9 1.8 -2.2 -0.9 0.1 -1.9 -1.1 -0.6 -0.4 1.1 0.1 -2.1
Arm fat percentage (left) 0.4 1.6 10.3 -1.9 0.2 -1.6 0.1 1.6 0.7 0.7 0.7 -0.4 1.2 -1.1 -1.7 -1.2 1.4 -0.2 -0.1 -0.3 -3.2
Average weekly red wine intake 0.9 1.4 4.3 1.5 1.4 1.9 1.0 0.3 0.7 0.7 0.8 -1.1 -0.6 0.9 1.2 0.9 0.3 -1.2 1.7 -2.1 -0.6
Handedness (chirality/laterality): Left-handed 2.0 2.5 6.7 -1.7 -2.1 -1.3 -0.9 -1.4 -2.1 -2.1 -2.1 1.0 1.6 0.2 -1.5 -1.2 0.6 -0.7 -1.7 -2.6 -1.0
Mood swings 1.2 2.2 7.4 -1.8 -2.3 -1.9 -1.9 -0.1 -1.2 -1.2 -1.3 1.5 0.0 -0.8 0.1 -2.3 0.4 -0.9 -1.6 -0.7 -2.7
Loneliness, isolation 0.6 0.8 4.6 -0.4 -0.8 -1.1 -1.5 0.6 0.1 0.1 0.0 0.3 0.0 -2.0 -0.6 -0.9 -0.3 -0.6 -0.4 -0.3 -2.1
Long-standing illness, disability or infirmity 1.1 1.6 6.0 -1.8 -1.8 -1.7 -1.7 1.1 -0.6 -0.6 -0.6 0.7 0.5 -0.9 -0.6 -2.5 0.5 0.3 -1.4 0.4 -2.1
Ever had bowel cancer screening 1.1 1.2 4.9 -0.8 -1.6 -1.0 -1.9 -0.8 -0.4 -0.4 -0.6 1.2 -1.1 0.4 -0.6 -1.5 -1.0 0.0 -2.2 1.1 0.4
Diabetes diagnosed by doctor 0.3 0.5 2.4 -0.3 -0.3 -0.6 -0.2 -0.1 0.9 0.9 0.8 0.5 -0.2 -1.5 -1.1 0.4 -0.1 0.1 -0.3 1.1 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.1 6.8 0.5 0.9 0.7 0.6 0.3 1.0 1.0 1.0 -1.3 0.3 -2.6 -1.3 -0.2 -0.7 -1.4 0.6 -1.3 -0.8
Friendships satisfaction 1.8 2.3 11.0 -1.0 -2.1 -1.0 -2.4 -0.7 -1.3 -1.3 -1.4 1.5 0.6 -3.3 -1.3 -1.1 -0.5 -0.3 -2.4 -0.5 -0.6
Qualifications: nursing, teaching 0.8 1.3 8.5 2.9 0.7 1.2 0.8 -0.3 -0.1 -0.1 -0.0 -2.0 -1.2 0.0 -0.0 1.6 -0.4 -0.5 1.0 -0.1 1.4
Commuting to job workplace: Walk 1.3 1.4 6.1 -1.1 -1.2 -0.2 -1.3 -1.8 -0.8 -0.8 -1.0 0.3 -0.4 -0.2 -1.6 -1.8 -2.5 -0.6 -1.8 -0.0 -0.0
Eye problems/disorders: Cataract 1.2 1.4 3.9 0.3 -0.4 1.3 0.0 -1.4 -1.2 -1.2 -1.2 -1.1 -1.4 1.2 -1.7 -1.4 -1.6 -2.0 0.5 -0.7 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 1.7 0.2 -0.7 1.3 -0.5 0.5 -0.2 -0.2 -0.3 -0.0 0.2 -0.2 0.9 0.7 1.3 0.4 -0.5 -0.7 -0.2
Medication for cholesterol 1.9 2.8 26.9 0.6 -0.7 0.6 -1.3 -0.9 0.2 0.2 0.1 2.1 -1.3 -0.5 0.4 0.2 -1.6 0.2 -2.2 2.4 5.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 3.2 -1.8 -1.1 0.1 -1.0 0.4 0.2 0.2 0.0 0.9 1.8 -1.4 -1.6 -1.5 -0.4 0.3 -0.7 0.4 -0.7
Back pain experienced in last month 1.7 2.5 8.6 -1.1 -2.1 -1.8 -2.9 -2.0 -0.5 -0.5 -0.7 1.8 -1.0 -0.7 1.1 -1.7 -2.6 -1.6 -1.6 1.9 -0.1
Mineral and other dietary supplements 1.2 1.6 6.1 1.2 1.9 0.5 2.5 0.8 0.6 0.6 0.8 -1.9 1.0 0.9 0.0 1.7 0.5 -0.1 1.0 -2.0 -1.5
Breast cancer (self-reported) 0.7 0.9 2.6 -0.7 0.7 -0.9 0.5 1.6 1.2 1.2 1.2 -0.8 1.0 0.3 0.9 0.5 0.0 1.4 1.1 0.8 -0.2
Asthma (self-reported) 0.6 1.2 6.4 0.3 0.0 0.5 0.3 1.4 1.7 1.7 1.6 -0.4 -0.2 -1.1 -0.5 -0.6 -0.0 1.1 0.1 2.5 1.5
Osteoporosis (self-reported) 2.1 2.6 7.2 1.6 1.3 2.7 1.2 1.5 2.3 2.3 2.3 -0.8 -0.1 1.6 2.5 0.8 1.0 0.1 1.5 1.6 0.7
Osteoarthritis (self-reported) 1.4 1.8 5.4 -1.7 -2.3 -1.7 -1.7 0.0 -0.7 -0.7 -0.8 1.8 1.4 -0.8 -0.2 -1.1 -0.8 1.4 -0.9 2.2 0.9
Medication: Aspirin 0.4 0.5 2.1 -1.4 -1.0 -1.0 -0.2 0.9 0.1 0.1 0.1 0.2 1.1 0.1 -0.7 -0.6 0.4 0.3 0.3 0.9 -0.4
Medication: Gliclazide 0.2 0.2 1.0 -0.0 -0.2 -0.3 0.0 0.7 0.5 0.5 0.5 0.4 0.9 0.7 -0.1 1.0 0.1 0.5 0.3 -0.3 0.1
Illnesses of father: None of the above (group 1) 0.8 0.9 6.5 -0.7 -0.2 0.2 0.7 -1.2 -1.2 -1.2 -1.1 -0.7 -0.2 1.3 -0.6 0.0 0.0 0.2 -0.4 -2.5 -1.1
Smoking status: Current 0.9 1.4 7.1 -1.0 0.6 -0.3 0.7 -0.2 -0.5 -0.5 -0.4 -1.4 -1.4 -2.7 -1.7 -0.6 0.3 0.3 0.6 -1.6 -2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.6 8.4 0.7 1.2 1.2 1.2 1.4 1.4 1.4 1.4 -0.2 -0.3 -0.0 -0.1 1.2 0.3 1.0 1.0 2.0 2.9
Whole body water mass 0.2 1.4 4.0 0.5 1.0 0.9 0.9 0.4 1.5 1.5 1.5 -2.0 -0.7 0.7 -1.6 -1.3 -1.2 -0.6 1.0 0.2 -1.9
Leg predicted mass (right) 0.4 1.9 5.2 0.6 1.5 1.0 1.6 1.0 1.8 1.8 1.8 -2.3 -0.9 0.1 -1.8 -1.1 -0.5 -0.4 1.1 0.0 -2.1
Arm fat mass (left) 0.4 1.7 12.2 -1.4 0.4 -0.8 0.4 1.2 0.9 0.9 0.9 -0.9 0.8 -0.7 -2.2 -1.8 0.7 -0.8 0.2 -0.4 -3.5
Number of self-reported non-cancer illnesses 0.7 1.3 3.5 -1.4 -1.5 -1.9 -1.2 0.9 -0.1 -0.1 -0.2 1.1 1.2 -0.7 -1.3 -1.4 1.0 0.6 -1.5 0.1 -1.6
Average weekly champagne plus white wine intake 0.4 0.5 1.8 1.0 0.4 0.9 0.3 -1.1 -0.5 -0.5 -0.4 -1.0 -0.4 -1.1 0.4 1.3 -0.1 -0.4 1.2 -0.3 0.1
Miserableness 0.7 1.3 5.0 -0.8 -1.6 -1.6 -1.9 0.5 0.1 0.1 -0.0 1.1 1.3 -1.4 -0.1 -1.2 1.1 -0.4 -0.6 0.5 -2.2
Guilty feelings 1.0 1.4 3.9 -0.5 -0.0 -1.8 -0.9 1.2 1.7 1.7 1.5 0.7 -0.1 1.6 0.5 -1.6 0.5 -0.1 -0.4 1.4 -2.0
Wears glasses or contact lenses 0.7 0.8 2.5 -0.5 -0.9 -1.2 -0.6 0.5 -0.6 -0.6 -0.6 1.6 1.4 -0.5 1.4 1.1 1.0 0.5 -0.7 -0.4 -0.3
Ever taken oral contraceptive pill 1.0 1.1 8.4 -0.9 0.4 -1.9 0.1 0.6 1.1 1.1 1.1 0.7 2.9 -0.9 -0.9 -0.7 -0.0 0.0 -0.1 -0.2 -0.2
Hearing aid user 0.5 0.6 1.9 -0.9 -0.2 0.6 -0.0 -1.3 -0.3 -0.3 -0.3 -0.9 -1.3 0.2 -0.3 -1.4 -1.3 -0.3 -0.3 0.0 -1.2
Mother’s age at death 0.8 1.0 6.0 0.6 -0.8 1.1 -1.0 -1.0 -0.7 -0.7 -0.8 0.9 -1.2 0.0 0.7 0.1 -1.1 0.3 -1.3 0.8 2.4
Financial situation satisfaction 1.0 1.2 5.7 -2.0 -1.4 -1.4 -0.4 0.9 -0.3 -0.3 -0.3 -0.5 0.0 -2.4 -1.3 -1.0 0.5 1.4 -0.1 -0.3 -1.3
Tinnitus: Yes, now most or all of the time 0.7 0.8 4.5 -0.9 -0.3 -2.1 -0.4 0.6 0.2 0.2 0.2 0.7 1.0 1.3 0.9 -1.0 0.5 1.5 0.0 -0.2 0.3
Commuting to job workplace: Public transport 0.8 1.0 4.8 -0.9 0.5 -1.3 0.4 0.8 0.7 0.7 0.7 0.1 0.9 -2.2 -1.1 0.7 1.6 1.5 0.4 0.2 -0.5
Eye problems/disorders: Glaucoma 1.4 1.7 5.6 2.1 1.5 1.2 1.7 1.4 1.6 1.6 1.6 0.3 0.9 -0.1 -0.4 1.1 2.4 0.1 1.1 0.6 0.9
Medication: Blood pressure 1.2 2.3 23.9 -0.7 0.0 -0.2 0.4 -0.4 -0.7 -0.7 -0.6 -1.5 0.8 0.7 -0.2 0.0 0.6 -1.3 1.7 -2.6 -4.9
Pain type(s) experienced in last month: Hip pain 0.8 1.0 3.8 -0.7 -0.2 -1.7 0.4 1.3 1.0 1.0 0.9 -0.0 0.3 -1.4 0.3 0.0 1.2 1.4 -0.6 1.9 0.7
Supplements: Fish oil (including cod liver oil) 2.7 3.5 10.8 -1.9 -3.0 -0.7 -3.3 -2.0 -1.7 -1.7 -1.8 2.3 -1.5 -0.8 0.3 -3.0 -1.4 -1.3 -2.2 0.9 0.6
High cholesterol (Self-reported) 1.2 2.2 5.4 -2.2 -2.2 -1.6 -1.5 -1.2 -1.1 -1.1 -1.2 0.8 2.1 -0.0 -1.8 -2.3 -1.0 -0.2 -0.9 -0.3 -1.6
Medication: Bendroflumethiazide 0.5 0.7 5.5 -0.3 1.0 0.2 0.3 1.2 0.7 0.7 0.8 -0.4 0.5 0.2 0.6 0.5 0.8 0.3 1.2 0.2 -2.3
Medication: Paracetamol 0.6 0.9 4.2 -0.5 -1.1 0.2 -1.4 0.7 0.6 0.6 0.4 2.1 0.3 0.3 2.0 -1.0 0.5 -0.2 -0.7 1.0 -0.7
Medication: Lisinopril 1.1 1.4 3.7 -1.6 -1.1 -1.7 -1.6 0.7 0.5 0.5 0.3 1.9 1.4 -0.6 -1.8 -1.1 -0.7 0.3 -1.2 1.0 -0.8
Medication: Atorvastatin 0.6 0.7 3.8 -1.2 -0.6 -2.0 -0.8 0.4 -0.2 -0.2 -0.2 0.5 1.6 -1.5 0.3 -0.1 0.6 1.0 -0.1 -0.1 -0.7
Illnesses of father: High blood pressure 1.7 2.1 13.5 -0.0 -0.1 -0.4 -1.3 0.3 1.8 1.8 1.6 0.8 -1.3 -0.6 -0.5 -1.3 -2.3 -0.0 -0.4 3.7 1.9
Alcohol drinker status: Never 0.6 0.7 4.8 1.3 1.0 0.8 1.2 0.0 -0.2 -0.2 -0.0 -2.2 -1.0 0.5 -0.4 0.7 0.7 -0.1 1.0 -0.4 -0.4
Ever smoked 0.8 1.4 3.3 -0.0 1.8 -0.2 1.5 1.2 1.5 1.5 1.6 -1.5 -0.8 -1.7 -0.1 -0.2 -0.2 0.2 1.8 1.1 -1.0
Basal metabolic rate 0.2 1.3 5.2 0.3 1.0 0.8 0.9 0.5 1.4 1.4 1.4 -1.8 -0.3 0.5 -1.7 -1.3 -0.8 -0.7 0.8 -0.0 -2.3
Leg fat percentage (left) 0.8 2.8 20.4 -2.7 -1.2 -1.6 -1.6 0.0 -0.9 -0.9 -1.0 0.3 1.2 -0.3 -1.8 -2.2 0.3 -1.5 -0.5 -1.3 -4.5
Arm fat-free mass (left) 0.3 1.5 5.6 0.4 0.8 1.2 0.8 0.3 1.3 1.3 1.2 -2.0 -0.4 0.8 -1.8 -1.6 -1.0 -1.0 1.0 -0.1 -2.4
Number of operations (self-reported) 3.1 4.5 13.5 -1.7 -3.7 -1.9 -3.3 -2.0 -2.1 -2.1 -2.3 2.4 0.2 -2.8 -1.8 -2.4 -1.9 -0.6 -2.3 0.7 0.0
Average weekly beer plus cider intake 0.9 1.3 4.8 -0.8 1.4 -0.5 1.8 0.6 0.4 0.4 0.6 -2.2 -0.6 -1.5 -1.3 0.2 0.2 1.5 1.6 -0.4 -1.6
Irritability 1.1 1.9 5.5 -0.7 -1.6 -1.9 -2.3 -0.8 -1.3 -1.3 -1.4 1.2 -0.1 -0.6 -0.6 -0.9 -1.0 -1.2 -1.0 -1.9 -2.4
Risk taking 5.0 7.3 19.1 2.0 4.4 2.0 3.7 3.0 4.0 4.0 4.2 -3.5 -0.2 -1.3 0.5 1.5 0.8 1.2 3.4 0.7 -1.2
Ever had prostate specific antigen (PSA) test 1.2 1.4 4.3 -0.4 -1.4 -1.4 -1.5 -1.2 -0.6 -0.6 -0.8 1.1 -1.4 0.8 0.5 0.3 -2.1 -0.9 -1.7 1.3 1.5
Fractured/broken bones in last 5 years 1.0 1.2 2.7 0.5 1.5 1.0 0.8 0.7 1.6 1.6 1.6 -1.4 0.1 -1.5 -1.0 -0.2 -1.1 0.9 1.0 0.7 1.0
Age started oral contraceptive pill 1.2 1.5 5.1 0.5 0.2 0.3 -1.1 0.8 1.4 1.4 1.2 2.0 1.0 0.9 2.2 0.7 0.0 -0.8 -1.7 1.7 1.4
Diastolic blood pressure, automated reading 1.0 3.0 5.6 -1.6 -2.2 -1.5 -1.8 -2.1 -2.3 -2.3 -2.4 0.5 -2.2 1.2 -0.4 -2.4 -2.1 -1.0 -1.7 -0.1 -0.8
Ever depressed for a whole week 1.2 1.5 5.8 -0.1 -0.7 -1.7 -0.8 0.8 0.8 0.8 0.7 1.0 1.2 -0.2 1.8 0.0 -0.4 1.4 -1.5 2.0 2.4
Unable to work because of sickness or disability 0.6 0.8 1.8 1.0 1.1 1.2 0.8 1.1 1.2 1.2 1.3 -0.8 0.2 -0.1 0.4 1.2 1.0 -0.6 0.2 -0.4 0.1
Commuting to job workplace: Cycle 1.2 1.4 6.8 1.7 1.6 1.3 1.6 -0.8 -0.3 -0.3 -0.1 -1.4 -2.6 1.1 0.7 1.3 -0.0 0.2 1.4 -1.0 0.5
Myopia 1.3 1.9 4.8 1.0 1.4 -1.1 1.3 1.8 1.6 1.6 1.7 -0.1 1.5 -0.2 2.2 2.0 1.8 1.7 0.5 -0.1 -0.3
Vascular/heart problems diagnosed by doctor 0.6 1.6 9.7 1.8 1.2 1.8 1.3 -0.2 0.4 0.4 0.6 0.3 -0.5 0.9 1.7 2.1 0.5 0.1 0.2 0.6 3.1
Cholesterol lowering medication 0.9 1.4 11.4 -0.7 0.6 0.3 0.9 -0.4 0.3 0.3 0.4 -1.7 0.3 -0.4 -1.4 -1.2 -0.7 -0.2 1.7 -0.9 -3.4
Medication: Omeprazole (e.g. Zanprol) 1.7 2.0 6.3 -0.4 0.9 -0.6 0.4 2.3 2.0 2.0 2.0 0.1 2.5 0.8 2.0 0.3 0.9 1.5 0.9 1.7 0.6
Pain experienced in last month 0.5 0.9 2.7 0.5 0.3 0.5 1.0 -1.5 -1.3 -1.3 -1.2 -0.6 -0.5 0.8 -1.6 0.4 -1.1 -0.3 -0.3 -1.4 0.7
Supplements: Calcium 1.0 1.1 4.3 1.1 0.7 1.1 0.2 1.3 0.9 0.9 0.9 1.2 2.1 -0.5 0.4 1.6 1.5 -0.3 0.5 0.2 0.9
Basal cell carcinoma (self-reported) 0.4 0.5 2.8 0.7 0.6 1.7 0.5 -0.6 0.3 0.3 0.3 -1.1 -0.9 0.3 0.2 -0.7 -0.3 -0.7 1.2 0.1 -0.4
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.9 -1.4 -0.1 -0.9 -0.1 -0.1 0.2 0.2 0.2 -1.1 -0.3 -1.3 -1.4 -1.4 -0.3 0.1 1.0 0.4 -1.1
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 3.3 -1.0 -0.9 -0.2 -1.1 1.1 1.3 1.3 1.1 -0.1 -0.5 -0.4 -0.1 -1.2 -0.0 1.3 -0.3 1.8 -0.7
Heart disease (siblings) 0.4 0.5 1.9 0.4 0.3 0.3 0.4 0.9 0.8 0.8 0.8 0.1 0.6 -0.9 -0.2 -0.8 1.4 -0.7 0.7 -0.1 -1.0
Alcohol drinker status: Previous 0.6 0.7 3.1 0.3 0.1 -0.2 0.9 -0.6 0.6 0.6 0.6 -0.5 -1.8 -0.5 -0.7 -1.3 -0.1 -0.8 -0.2 0.9 1.5
Pack years of smoking 0.4 0.6 3.1 0.1 -0.7 -0.3 -0.6 -0.4 0.1 0.1 0.1 -0.5 0.4 -0.8 -1.4 -1.1 -1.3 -0.1 -0.4 -0.9 -1.8
Impedance of whole body 0.4 2.1 9.6 -0.0 0.2 -1.6 0.1 0.6 -1.1 -1.1 -1.0 1.8 2.4 0.0 2.5 2.0 3.1 0.5 -1.0 -1.0 0.2
Leg fat mass (left) 0.6 2.5 19.3 -2.2 -0.8 -1.2 -1.0 0.0 -0.2 -0.2 -0.3 -0.3 0.9 -0.7 -2.3 -2.5 -0.2 -1.8 -0.1 -0.9 -4.4
Arm predicted mass (left) 0.2 1.2 4.4 0.2 0.7 0.9 0.5 0.3 1.4 1.4 1.3 -1.7 -0.2 0.8 -1.4 -1.6 -1.0 -0.7 0.9 0.3 -2.1