TWAS hub - PPP1R21

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1920	0.0530	1.8e-06	0.057	NA	0.062	NA	0.075	4.6e-04	NA	2.6e-04	NA	6.3e-05
2	GTEx	Artery Tibial	0.0950	0.0446	5.8e-03	0.006	NA	0.001	NA	0.003	9.9e-02	NA	2.7e-01	NA	1.6e-01
3	GTEx	Breast Mammary Tissue	0.1970	0.0650	2.0e-04	0.010	NA	0.036	NA	0.047	9.7e-02	NA	6.1e-03	NA	1.9e-03
4	GTEx	Breast Mammary Tissue (Male)	0.4621	0.1236	1.8e-03	0.026	NA	0.077	NA	0.103	8.5e-02	NA	7.6e-03	NA	2.2e-03
5	GTEx	Cells Transformed fibroblasts	0.0770	0.0350	4.2e-03	0.089	NA	0.062	NA	0.075	3.6e-07	NA	2.1e-05	NA	2.8e-06
6	GTEx	Esophagus Mucosa	0.1610	0.0570	4.9e-05	0.070	NA	0.030	NA	0.022	1.9e-05	NA	4.2e-03	NA	1.1e-02
7	GTEx	Skin Not Sun Exposed Suprapubic	0.2140	0.0780	6.3e-04	0.026	NA	0.028	NA	0.007	1.4e-02	NA	1.1e-02	NA	1.3e-01
8	GTEx	Skin Sun Exposed Lower leg	0.1380	0.0590	8.3e-04	0.011	NA	0.064	NA	0.043	3.7e-02	NA	5.4e-06	NA	1.7e-04
9	GTEx	Testis	0.2970	0.0810	8.3e-07	0.149	NA	0.177	NA	0.154	4.0e-07	NA	2.7e-08	NA	2.5e-07
10	GTEx	Thyroid	0.4620	0.0580	0.0e+00	0.375	NA	0.444	NA	0.423	4.5e-30	NA	4.1e-37	NA	6.1e-35
11	METSIM	Adipose	0.0356	0.0168	2.1e-03	0.002	0.019	0.013	0.017	0.010	1.6e-01	5.5e-04	4.3e-03	1.1e-03	9.0e-03
12	ROSMAP	Brain Pre-frontal Cortex	0.1626	0.0373	6.1e-13	0.139	0.107	0.112	0.131	0.133	1.7e-17	1.1e-13	2.8e-14	1.8e-16	8.8e-17

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Lung FVC	6.6	33.6	56.4	7.0	5.4	5.1	1.9	7.5	7.0	5.2	4.9	5.8	6.5	4.9	6.2
Handedness (chirality/laterality): Left-handed	6.6	8.0	15.1	-3.0	-2.3	-3.0	-2.0	-3.9	-3.6	-2.0	-2.5	-2.2	-3.2	-2.4	-2.9
Hand grip strength (right)	5.7	15.5	31.9	5.2	2.8	4.0	2.1	5.7	4.2	2.5	1.8	3.8	4.7	4.5	3.8
Irritability	5.5	9.2	17.8	-3.9	-3.3	-1.7	-1.4	-4.2	-2.6	-2.6	-2.2	-3.5	-3.7	-2.9	-3.1
Family relationship satisfaction	5.3	6.6	17.0	-3.7	-2.6	-0.3	-0.1	-2.8	-2.6	-0.2	-2.9	-0.9	-4.0	-4.1	1.2
Bilateral oophorectomy (both ovaries removed)	4.6	5.3	16.3	-2.7	-1.9	-2.5	-1.3	-2.7	-4.0	-1.7	-2.2	-0.2	-3.0	-2.0	1.1
Peak expiratory flow (PEF)	4.3	10.0	17.2	3.6	3.4	2.9	2.9	4.1	3.6	1.5	1.0	3.7	2.9	3.2	3.8
Hand grip strength (left)	4.1	10.8	19.2	4.4	1.8	3.6	3.0	4.4	3.1	1.9	1.6	3.2	3.4	3.6	3.9
Long-standing illness, disability or infirmity	3.9	6.0	12.2	-3.3	-2.7	-2.2	-1.4	-2.9	-2.8	-2.6	-0.5	-0.7	-3.5	-3.2	0.4
Osteoporosis (self-reported)	3.8	4.6	12.4	2.1	1.4	3.1	2.2	1.6	1.5	2.4	3.5	1.5	2.2	0.8	2.1
Health satisfaction	3.7	4.7	8.1	-2.5	-2.0	-2.4	-1.4	-2.7	-2.8	-1.6	-1.8	-2.1	-2.4	-2.6	-0.7
Mood swings	3.7	6.7	11.5	-3.0	-3.2	-2.0	-1.3	-3.3	-2.9	-2.3	-1.4	-3.1	-3.4	-2.7	-0.7
Illnesses of father: High blood pressure	3.7	4.6	15.1	1.6	1.0	3.9	2.3	2.6	1.1	0.3	-0.7	2.3	1.2	1.0	3.8
Overall health rating	3.6	7.6	16.4	-3.6	-3.6	-2.5	-1.7	-3.2	-2.6	-2.5	-0.3	-1.4	-4.1	-3.8	-0.3
Number of self-reported non-cancer illnesses	3.4	5.9	12.5	-3.2	-2.6	-2.9	-1.8	-3.0	-2.6	-2.3	-0.8	-0.7	-3.5	-2.5	0.2
Depressed Affect (Nagel 2018)	3.3	6.9	16.7	-3.8	-3.2	-0.5	-1.2	-3.5	-2.1	-0.8	-1.1	-3.2	-4.1	-3.1	-1.1
Neuroticism score	3.3	7.0	15.9	-3.4	-3.3	-0.7	-0.6	-3.5	-3.1	-2.0	-2.2	-2.2	-4.0	-2.9	0.3
Friendships satisfaction	3.1	3.9	9.2	-2.5	-1.4	-0.9	0.2	-2.3	-2.4	-0.7	-3.0	-1.5	-2.8	-2.6	0.2
Medication for cholesterol	3.1	4.7	10.3	2.3	2.9	2.2	1.5	2.5	1.5	1.8	0.2	2.7	2.1	1.3	3.2
Noisy workplace	3.0	3.7	8.6	-2.9	-0.6	-2.1	-0.9	-2.2	-2.1	-2.6	-1.9	-0.1	-2.9	-1.3	-1.1
Medication: Blood pressure	2.9	5.6	9.4	-2.6	-3.1	-2.3	-1.1	-2.9	-2.4	-2.4	-0.6	-2.6	-2.4	-1.6	-3.0
Neuroticism (Nagel 2018)	2.8	6.7	14.4	-3.4	-3.3	-1.0	-1.7	-3.2	-2.5	-1.4	-2.2	-3.0	-3.8	-2.7	-0.3
Fasting Glucose	2.8	3.4	11.1	2.1	1.6	2.1	0.9	2.1	0.5	0.4	0.1	2.7	1.4	1.6	3.3
Lupus	2.8	4.2	10.7	-2.3	-2.1	-2.1	-2.8	-2.6	-3.3	-0.8	-1.8	-0.8	-2.2	-1.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.8	5.9	10.7	3.3	2.5	2.0	0.6	3.3	2.9	1.1	1.2	2.4	3.2	2.3	2.6
Miserableness	2.7	4.7	12.5	-3.3	-2.6	-0.5	0.2	-2.8	-2.0	0.8	-0.3	-2.0	-3.5	-3.0	-0.6
Neuroticism	2.6	6.2	14.2	-3.3	-3.4	-0.8	-1.1	-3.3	-2.5	-2.1	-1.6	-2.1	-3.8	-2.7	-0.3
Taking other prescription medications	2.6	4.1	7.4	-2.5	-1.6	-2.3	-1.5	-2.3	-2.5	-2.3	-0.3	0.5	-2.7	-2.1	1.8
Pack years of smoking	2.6	3.8	8.3	-2.8	-2.5	-1.5	-1.8	-2.3	-2.3	-1.5	-0.4	-1.1	-2.9	-1.5	-0.9
Chest pain or discomfort	2.5	3.7	6.8	-1.9	-2.6	-1.9	-0.6	-1.4	-2.0	-1.5	-2.2	-2.5	-2.4	-1.8	-1.1
Ovarian Cancer	2.4	3.2	6.2	0.6	1.1	1.3	1.6	2.0	2.4	2.5	1.5	2.5	0.4	1.5	2.5
Fed-up feelings	2.4	4.3	10.4	-3.0	-2.3	-0.9	-0.2	-2.7	-1.6	-0.9	-0.4	-2.7	-3.2	-2.5	-1.2
Tense / ‘highly strung’	2.4	4.0	6.2	-2.1	-2.4	-1.7	-1.0	-2.5	-2.5	-1.7	-0.2	-2.5	-2.1	-2.4	-1.6
Neuroticism (2016)	2.3	3.3	9.5	-2.4	-1.5	-0.9	-1.4	-3.1	-2.2	-1.8	-1.0	-0.8	-2.4	-2.0	-0.3
Waist Hip Ratio (WHR)	2.3	10.3	20.2	-4.0	-1.8	-4.5	-2.0	-3.5	-4.2	-1.3	-4.0	-2.2	-3.6	-1.3	-3.5
Chronic bronchitis/emphysema (mother)	2.3	2.7	5.4	-2.0	-0.6	-1.8	-1.3	-2.2	-1.9	0.7	0.4	1.4	-2.3	-2.3	0.9
Townsend deprivation index at recruitment	2.2	3.1	6.2	-1.7	-2.4	-1.5	-0.9	-1.8	-1.5	-1.7	-0.6	-2.1	-1.6	-1.9	-2.5
Birth weight	2.2	4.8	10.0	-1.9	-2.7	-0.6	0.1	-2.9	-2.0	-3.2	-2.5	-3.0	-2.4	-1.4	-0.7
HbA1C	2.1	2.3	4.6	2.1	2.1	-0.0	-0.3	2.0	0.7	-0.2	0.3	2.1	1.7	1.9	1.7
Pack years adult smoking proportion	2.1	3.2	6.3	-2.5	-2.5	-1.1	-1.9	-2.0	-2.2	-1.6	-0.6	-1.1	-2.4	-1.1	-1.2
Forced vital capacity (FVC), Best measure	2.1	7.6	16.7	4.1	1.6	2.9	-0.1	3.9	3.4	1.4	1.0	0.9	3.9	3.6	2.1
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	6.2	-2.0	-1.5	-0.7	-0.2	-1.6	-1.7	-0.4	0.1	1.7	-2.5	-2.2	2.3
Nervous feelings	2.0	3.7	8.2	-2.1	-1.3	-2.2	-1.6	-2.1	-2.6	-1.5	-2.9	-1.8	-2.3	-1.0	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	5.9	12.2	3.3	1.8	3.1	1.1	3.5	3.1	1.5	0.8	0.9	2.9	2.9	1.9
Age started oral contraceptive pill	1.9	2.4	10.9	1.0	0.7	1.7	0.1	1.7	0.8	0.5	1.1	3.3	0.6	-0.0	2.8
Worrier / anxious feelings	1.8	3.4	6.2	-2.2	-1.6	-1.9	-2.5	-2.1	-2.1	-1.6	-1.6	-0.4	-2.4	-1.8	0.6
Forced expiratory volume in 1-second (FEV1)	1.8	6.2	11.9	3.3	2.2	2.9	1.3	3.5	3.2	1.1	0.7	1.5	2.9	3.4	1.8
Leg fat percentage (right)	1.8	6.4	16.6	-3.1	-3.4	-2.0	-0.6	-3.0	-2.6	-2.8	0.4	-1.4	-4.1	-2.9	-0.6
Wheeze or whistling in the chest in last year	1.8	3.3	8.1	-1.5	-2.8	0.3	-1.0	-1.7	-2.5	-2.5	-2.0	-1.5	-1.9	-1.7	0.7
Worry (Nagel 2018)	1.7	3.6	7.0	-2.2	-1.7	-1.4	-1.6	-2.4	-2.2	-1.0	-1.7	-2.2	-2.7	-2.0	0.1
Breast Cancer	1.7	4.0	7.4	2.5	2.7	2.2	2.5	1.8	2.3	1.7	0.7	0.9	2.6	1.2	1.6
Number of incorrect matches in round	1.7	2.8	6.5	-2.2	-1.5	-2.2	-2.5	-1.7	-1.3	-1.0	-0.9	-0.9	-2.1	-0.6	-1.9
Breastfed as a baby	1.7	2.1	5.4	1.7	1.8	1.9	1.3	0.9	1.2	0.1	1.2	1.7	1.3	0.0	2.3
Loneliness, isolation	1.7	2.4	5.5	-2.4	-1.8	0.0	-0.5	-1.5	-1.2	-2.2	-1.1	-1.6	-2.0	-1.8	-0.6
Financial situation satisfaction	1.7	2.1	5.2	-1.6	-1.5	-1.5	0.4	-2.3	-1.4	-0.5	-0.1	-1.8	-1.8	-1.4	-1.1
Depression (Nagel 2018)	1.6	2.5	7.3	-1.9	-2.1	-0.8	-1.1	-1.7	-0.7	0.2	-0.7	-2.7	-2.2	-1.5	-1.1
Current tobacco smoking	1.6	2.6	8.2	-1.1	-1.8	-0.4	-0.0	-1.7	-0.8	-1.6	-1.4	-2.9	-0.7	-1.4	-2.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	5.0	-1.8	-1.4	-1.6	-1.1	-1.3	-1.2	-0.5	-0.7	-2.2	-1.9	-1.0	-1.8
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.4	5.1	-2.1	-2.1	-1.0	-0.9	-1.3	-1.1	0.5	-0.1	-2.2	-1.7	-1.9	-1.9
Forced vital capacity (FVC)	1.6	6.3	16.0	3.6	1.6	2.3	-0.2	3.5	3.3	0.7	0.6	1.2	3.3	4.0	1.6
Happiness	1.6	2.0	6.9	-1.9	-0.8	-0.8	-0.9	-1.9	-1.0	1.4	-0.4	-0.8	-2.6	-1.9	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.5	5.3	-1.1	-2.2	-0.9	-1.6	-1.6	-2.3	-1.3	-0.9	-2.2	-1.1	-1.8	-0.8
Birth weight of first child	1.6	3.0	9.7	1.7	1.9	1.7	1.8	1.5	0.9	0.1	-0.1	2.9	1.0	1.0	3.1
Smoking status: Current	1.6	2.6	8.4	-1.1	-1.8	-0.5	-0.0	-1.7	-0.9	-1.6	-1.6	-2.9	-0.9	-1.5	-2.4
Risk taking	1.6	2.3	5.7	2.0	0.4	2.4	1.4	2.0	2.0	0.9	1.1	0.5	2.0	1.2	-0.2
Age at First Birth	1.5	2.1	6.5	1.2	2.5	1.0	0.7	1.0	2.1	0.7	1.1	0.6	1.7	2.3	-0.6
Primary Biliary Cirrhosis	1.5	2.2	4.2	-1.2	-1.9	-1.5	-0.9	-1.4	-1.6	-1.1	-1.1	-2.1	-0.6	-1.9	-1.7
Number of treatments/medications taken	1.5	2.7	5.6	-2.1	-1.9	-0.8	-0.8	-2.4	-2.0	-1.1	0.6	-0.5	-2.4	-2.4	0.8
Ever used hormone-replacement therapy (HRT)	1.5	1.9	3.8	-1.7	-1.6	-1.3	-1.1	-1.6	-0.8	-1.0	0.3	-1.6	-1.9	-2.0	-0.7
Medication for hormone replacement therapy	1.5	1.7	5.0	-1.4	-1.8	-1.4	-0.5	-1.0	0.6	0.0	-0.2	-2.2	-1.0	-1.1	-2.0
High blood pressure (mother)	1.5	2.1	6.0	-1.9	-1.8	-0.9	0.2	-1.8	-2.2	-0.9	-0.5	-0.8	-2.5	-1.4	0.5
Alcohol usually taken with meals	1.5	2.4	7.1	1.3	2.7	0.9	-0.1	1.3	2.4	2.2	0.7	1.4	1.9	0.7	0.2
Mouth/teeth dental problems	1.5	2.4	5.5	1.2	1.7	1.3	1.0	2.0	1.8	1.4	0.1	1.4	2.4	2.0	-0.3
Impedance of arm (right)	1.5	7.2	16.6	-2.4	-3.0	-1.4	-3.0	-3.1	-3.9	-2.3	-4.1	-1.4	-2.8	-1.6	-1.6
Pulse rate	1.5	2.5	10.0	0.7	3.2	0.7	0.9	1.0	0.9	1.5	1.6	1.9	0.0	1.3	2.4
Exposure to tobacco smoke at home	1.5	1.7	9.2	-0.2	-0.1	-0.4	0.0	-1.0	-0.6	0.8	0.5	-3.0	-0.4	-1.5	-2.5
Illnesses of father: None of the above (group 1)	1.5	1.8	5.0	-1.5	-1.2	-2.2	-0.2	-1.4	-1.8	-0.2	-0.3	-1.1	-1.1	-0.4	-2.1
LDL Cholesterol	1.4	2.3	6.5	1.4	1.6	0.4	-1.0	2.0	0.7	1.6	1.1	2.5	1.2	2.0	1.2
Impedance of leg (right)	1.4	7.0	25.0	-2.2	-2.7	-1.3	-5.0	-2.3	-3.4	-2.2	-3.2	-1.6	-2.0	-1.1	-2.2
Supplements: Glucosamine	1.4	1.8	5.1	0.4	1.3	-0.4	-0.7	1.7	1.3	2.0	0.3	2.2	0.4	0.1	2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.9	4.2	-0.7	-1.6	-0.0	-1.3	-1.0	-1.9	-1.4	-1.1	-2.1	-0.0	-1.5	-1.8
Qualifications: College or University degree	1.4	4.3	14.5	2.3	2.6	2.1	-0.6	2.0	2.1	2.7	-0.2	-0.4	3.8	1.9	-1.2
Commuting to job workplace: Public transport	1.4	1.7	4.9	-1.0	-1.4	-1.0	0.4	-1.4	-1.4	-2.2	-1.8	-0.1	-1.4	-1.6	0.0
Medication: Lisinopril	1.4	1.8	5.9	-1.7	-0.9	-0.1	-2.0	-1.6	-1.3	-1.7	-0.6	0.3	-2.4	0.0	0.6
Leg fat percentage (left)	1.4	5.1	13.8	-2.8	-3.1	-2.0	-0.1	-2.6	-2.1	-2.5	0.5	-1.4	-3.7	-2.5	-0.4
Impedance of whole body	1.4	7.2	14.9	-2.2	-2.9	-1.4	-3.8	-2.8	-3.7	-2.4	-3.9	-1.8	-2.3	-1.4	-2.1
Schizophrenia (2014)	1.3	3.0	7.0	2.1	1.0	2.2	0.5	2.5	2.0	1.6	0.8	1.6	2.6	0.7	0.8
Type 2 Diabetes (T2D) (2012)	1.3	1.6	10.4	1.0	0.8	-0.9	-1.4	0.7	0.1	-0.1	0.7	1.5	0.8	3.2	0.0
Average weekly spirits intake	1.3	1.7	10.2	-0.8	0.2	-1.0	-0.5	0.4	1.7	1.7	3.2	0.7	-0.9	-0.5	0.1
Vitamin and mineral supplements	1.3	1.7	4.2	0.8	0.8	-2.0	-1.9	-0.3	-1.0	-1.4	1.7	0.5	0.8	1.4	-1.6
Diabetes (father)	1.3	1.6	6.3	0.7	0.8	1.4	-0.1	1.7	0.9	1.1	0.9	2.5	0.8	0.5	1.8
Qualifications: A levels/AS levels or equivalent	1.3	2.8	10.3	2.3	1.7	0.2	-1.0	1.5	1.7	0.9	-0.5	-0.3	3.2	2.3	-1.5
Impedance of arm (left)	1.3	6.1	15.6	-2.2	-2.7	-1.0	-2.4	-2.7	-3.4	-2.5	-4.0	-1.6	-2.2	-1.8	-1.9
Eye problems/disorders: None of the above	1.3	1.6	3.1	-1.4	-1.8	-1.1	-0.2	-1.4	-1.5	-1.5	-1.5	-0.7	-1.2	-1.3	-0.4
Illnesses of siblings: Diabetes	1.3	1.6	5.0	-1.9	-1.2	-0.7	-0.5	-1.9	-1.4	-0.8	0.3	-0.1	-2.2	-1.3	0.2
Back pain experienced in last month	1.3	1.9	6.9	-1.2	-1.3	1.2	0.9	-1.0	-1.0	-0.4	-0.2	1.4	-1.8	-1.9	2.6
Eye problems/disorders: Glaucoma	1.3	1.5	3.5	0.5	1.1	0.4	-0.8	1.3	1.9	1.6	1.6	1.6	0.9	1.3	0.3
High cholesterol (Self-reported)	1.3	2.3	6.2	-2.1	-0.4	-2.4	-1.8	-1.7	-1.7	-0.4	-0.0	-0.3	-2.5	-1.6	-0.4
Fractured/broken bones in last 5 years	1.3	1.7	3.9	1.1	1.0	1.7	-0.7	1.4	2.0	0.8	1.3	1.1	1.6	1.4	0.7
Maternal smoking around birth	1.2	1.8	4.3	-1.2	-2.1	-1.7	-1.2	-0.5	-1.6	-0.3	0.0	-1.2	-1.6	-2.1	-0.1
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	2.4	-1.5	-1.4	-0.5	0.9	-1.5	-1.6	-0.5	-1.0	-1.4	-1.3	-0.9	-0.6
Medication: Levothyroxine sodium	1.2	2.0	4.9	-2.0	-0.8	-1.8	-0.4	-1.6	-0.8	-1.8	0.8	0.8	-2.2	-1.7	0.9
Impedance of leg (left)	1.2	5.7	19.7	-1.9	-2.5	-1.2	-4.4	-2.0	-2.9	-2.0	-3.1	-1.8	-1.6	-0.7	-2.3
Hair/balding pattern: Pattern 2	1.2	1.5	5.2	1.0	-0.7	2.3	1.2	1.3	2.0	-0.3	1.1	-0.1	0.7	-0.0	1.6
Time employed in main current job	1.2	1.4	3.1	1.3	0.9	0.6	-1.6	1.1	1.0	0.8	0.8	1.8	1.7	0.8	1.2
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	5.4	-1.6	-1.8	0.3	-0.0	-1.3	-0.9	-2.3	-0.2	-1.7	-1.6	-1.4	-1.1
Depression (self-reported)	1.2	1.5	3.2	-0.6	-1.1	-1.0	-0.8	-1.6	-1.8	-1.8	-1.4	-1.6	-0.5	-0.4	-0.7
Pulse wave peak to peak time	1.2	1.4	4.4	1.4	1.0	1.2	-0.9	1.5	1.7	0.7	0.4	-0.9	2.1	0.8	-0.3
Hypertension (Self-reported)	1.2	3.5	8.5	-2.3	-1.6	-1.5	-1.0	-2.9	-2.2	-1.9	-1.1	-1.5	-2.6	-1.5	-1.2
Average weekly red wine intake	1.2	1.7	6.5	1.1	1.0	-0.2	-1.1	0.5	1.3	0.9	1.3	-0.8	2.3	0.9	-2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	4.2	-1.2	-1.1	-0.9	-1.9	-1.0	-0.8	-2.1	-0.4	-1.1	-1.4	-0.9	0.0
Mineral and other dietary supplements	1.2	1.6	5.8	-0.3	-0.4	-0.7	-0.5	-1.0	-1.3	-2.4	-0.7	-1.7	-0.3	0.8	-2.2
Medication: Bendroflumethiazide	1.2	1.9	5.0	-1.5	-2.2	-0.9	-0.8	-1.7	-1.6	-1.7	-0.6	-1.2	-1.5	-0.6	-0.9
Number of operations (self-reported)	1.2	1.8	5.1	-2.2	0.2	-1.4	-1.3	-1.3	-0.6	0.9	0.3	0.3	-2.1	-1.9	1.4
Schizophrenia (2018)	1.1	2.3	6.7	1.9	0.4	2.6	1.3	2.0	1.2	1.4	0.3	1.0	2.3	0.7	0.8
Alzheimer’s Disease (in father)	1.1	1.2	5.1	0.7	1.0	0.3	-0.8	1.0	2.2	1.4	1.8	0.7	0.8	0.6	-0.1
Chronotype (morning person)	1.1	2.4	4.9	-1.9	-1.4	-1.4	-0.6	-2.2	-2.0	0.2	-1.8	-0.5	-1.9	-1.9	1.4
Severe depression (siblings)	1.1	1.3	4.9	0.4	-1.1	0.9	2.2	-0.1	-0.3	0.8	-1.7	-1.9	-0.3	0.4	-0.9
Multivitamins +/- minerals	1.1	1.4	2.6	-1.4	-1.2	1.6	1.3	0.0	0.8	1.3	-1.4	0.1	-1.3	-1.4	1.2
Fluid intelligence score	1.1	2.2	5.4	1.7	2.3	0.9	-0.0	1.2	1.6	1.8	1.6	1.1	2.1	1.3	0.8
Alcohol intake versus 10 years previously	1.1	1.7	3.6	-1.7	-1.2	0.2	0.4	-1.9	-1.5	-0.9	0.4	-1.4	-1.7	-0.9	-1.8
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.3	4.2	0.2	1.0	-0.4	-2.0	1.0	1.4	2.0	1.7	0.6	0.2	-0.0	-0.5
Pulse wave Arterial Stiffness index	1.1	1.3	3.6	-1.2	-1.0	-1.0	1.1	-1.3	-1.6	-0.7	-0.6	1.0	-1.9	-0.7	0.6
Medication: Paracetamol	1.1	1.9	8.7	-0.7	0.2	1.6	0.3	-0.0	1.0	1.6	3.0	1.0	-1.4	-1.8	1.1
Body fat percentage	1.1	4.4	12.4	-2.3	-3.0	-1.2	0.5	-2.4	-2.0	-2.7	-0.3	-0.9	-3.5	-2.5	-0.1
Number of full sisters	1.1	1.4	3.6	-1.3	-1.9	-0.4	-0.4	-1.0	-1.6	-1.4	-0.5	-0.1	-1.9	-1.1	0.4
Ever smoked	1.1	2.0	4.8	1.8	0.5	2.2	1.0	1.3	2.1	1.6	1.5	-0.7	1.4	1.1	0.5
Sensitivity / hurt feelings	1.0	1.7	7.8	-0.7	-0.7	1.6	1.3	-0.5	-0.9	-0.2	-1.9	0.1	-1.5	-1.1	2.8
Trunk fat percentage	1.0	3.9	10.2	-1.9	-2.8	-1.1	0.7	-2.3	-2.1	-2.9	-0.8	-0.9	-3.2	-2.1	-0.0
Chronic bronchitis/emphysema (father)	1.0	1.2	3.4	-1.2	-1.2	-0.8	-0.9	-0.6	-1.9	-0.5	0.3	0.3	-1.6	-1.4	1.2
Length of working week for main job	1.0	1.1	3.1	-1.1	-1.2	-0.5	0.3	-1.4	-0.4	-0.8	-0.2	-1.8	-0.9	-0.9	-1.7
Hair/balding pattern: Pattern 4	1.0	2.4	15.3	-1.1	0.9	-1.8	-0.3	-1.7	-0.8	-1.0	-0.8	-1.8	0.1	0.1	-3.9
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.2	1.8	1.1	1.3	0.6	1.8	1.4	1.1	1.0	0.8	1.4	1.3	1.1
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	9.2	0.6	-0.8	-0.1	0.5	0.2	0.6	0.2	0.1	-2.5	1.1	0.9	-3.0
Emphysema/chronic bronchitis	1.0	1.1	6.0	0.7	-0.9	0.5	1.3	0.6	-0.1	-1.2	-0.1	1.5	0.1	-0.4	2.4
Neck or shoulder pain in last month	1.0	1.5	3.5	-0.3	-1.8	-0.5	0.1	-0.7	-1.6	-1.7	-0.7	-1.7	-0.7	-1.9	-0.4
Leg fat mass (right)	1.0	4.0	11.2	-2.4	-2.8	-1.0	0.6	-2.1	-1.7	-2.6	0.4	-1.3	-3.3	-2.5	-0.2
Had major operations	1.0	1.2	4.1	-1.9	-0.8	-0.9	0.5	-1.3	-0.7	0.3	0.2	-0.3	-1.7	-2.0	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	4.8	-1.2	-1.5	-0.6	-0.7	-0.7	-1.1	-1.2	-2.2	-0.8	-1.2	-0.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	4.3	-0.5	-1.2	-1.1	0.1	-1.4	-1.8	-1.3	-0.5	-2.1	-0.8	-1.5	-1.0
Osteoarthritis (self-reported)	1.0	1.3	3.8	-1.0	0.4	-2.0	-0.8	-0.6	0.4	0.3	1.5	1.2	-1.6	-0.8	1.5
Medication: Paracetamol	1.0	1.5	4.0	-1.5	-1.0	1.0	-0.3	-1.2	-0.0	0.9	1.9	-0.7	-1.9	-2.0	-0.2
Ever had prostate specific antigen (PSA) test	1.0	1.1	5.5	0.5	0.8	-0.1	-0.7	1.2	0.1	-0.6	-0.8	1.6	0.6	1.1	2.3
Bipolar Disorder (2011)	0.9	0.9	2.7	1.1	0.3	1.6	0.1	1.2	0.8	0.6	-0.6	0.9	0.9	0.6	1.3
Coronary Artery Disease (CAD)	0.9	1.1	5.3	-0.5	-0.7	-0.8	-0.3	-0.7	-2.3	-0.9	-0.9	1.2	-0.8	0.4	1.2
Diabetes (mother)	0.9	1.1	8.7	0.8	0.7	0.4	3.0	0.9	0.0	-1.4	0.2	-0.3	0.8	0.7	0.2
Waist circumference	0.9	3.4	11.1	-2.6	-2.0	-1.6	0.8	-2.1	-1.8	-1.8	-0.6	-0.2	-3.3	-1.9	-0.1
Hearing difficulty/problems with background noise	0.9	1.4	3.6	-1.1	-1.6	-1.6	-1.6	-0.4	-1.9	-1.5	-0.7	-0.5	-0.9	-0.9	-0.2
Medication: Simvastatin	0.9	1.3	3.9	-1.7	0.4	-1.4	-0.6	-1.8	-0.8	-0.4	0.9	-0.6	-2.0	-1.1	-0.6
Number of live births	0.9	1.2	5.5	1.6	0.1	1.5	0.2	2.4	0.2	1.0	0.0	0.0	1.4	-0.2	1.1
Headache pain in last month	0.9	1.5	8.0	-0.4	0.3	-0.2	-0.9	0.0	0.8	2.3	2.8	0.8	0.2	-1.0	-1.1
Worry too long after embarrassment	0.9	1.5	7.8	-0.2	-2.1	1.0	0.4	-0.8	-1.0	-1.1	-0.8	0.3	-1.0	-0.6	2.8
Medication for pain relief, constipation, heartburn	0.9	1.5	8.0	0.6	0.0	0.6	2.8	0.2	0.2	-0.9	-2.0	-1.2	1.1	1.0	-0.6
Medication: Omeprazole	0.9	1.1	9.4	-0.7	0.3	-0.4	-3.1	0.1	0.2	0.4	-0.8	1.4	-0.0	0.2	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	2.9	-0.5	0.8	1.7	1.1	0.5	-0.5	0.2	-0.6	1.7	-0.5	-0.9	1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	8.6	-1.0	-1.7	-0.5	-0.5	-0.8	-0.9	-1.1	-2.9	-1.7	-1.2	0.9	-1.1
Ever had bowel cancer screening	0.9	1.0	3.7	-0.7	-0.1	-0.7	0.4	0.1	-0.6	-1.4	-1.1	1.4	-0.7	-1.3	1.9
Eye problems/disorders: Cataract	0.9	1.0	2.4	1.4	1.3	0.2	-0.2	1.6	1.2	1.1	1.3	0.0	1.1	0.8	0.3
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.5	-1.4	-0.5	-0.6	-0.7	-1.0	-1.1	-1.6	-0.9	0.3	-1.0	-0.8	-1.3
Pain type(s) experienced in last month: Hip pain	0.9	1.1	5.1	1.0	0.3	-0.4	1.3	0.5	-0.4	-0.8	0.5	2.1	0.2	-0.1	2.2
Vascular/heart problems diagnosed by doctor	0.9	2.5	6.4	2.1	1.1	1.8	0.4	2.5	1.8	0.9	0.7	0.7	2.5	1.6	1.0
Alcohol drinker status: Previous	0.9	1.0	2.9	0.5	0.8	1.5	0.0	0.9	0.6	1.4	-0.6	1.6	0.0	0.2	1.7
Reaction Time	0.8	1.5	3.9	-1.5	-1.8	-0.8	-1.4	-1.4	-1.1	-0.8	-0.8	-0.7	-2.0	-1.0	0.6
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.9	1.5	2.0	0.3	-0.5	1.4	1.6	1.3	1.2	1.8	1.8	1.6	0.6
Crohns Disease (2012)	0.8	1.4	5.0	0.5	0.6	-1.2	-1.8	0.7	-0.2	-1.1	-0.4	0.1	1.3	1.6	-2.2
Mean Putamen Volume	0.8	0.9	2.0	-0.9	-0.6	-1.3	0.5	-0.6	-1.4	-1.3	-1.0	0.7	-0.9	-0.2	0.8
HDL Cholesterol	0.8	1.3	4.3	2.1	0.8	1.3	-0.1	1.3	1.2	0.7	0.5	0.5	1.7	1.1	0.9
Cardiovascular Disease	0.8	2.5	7.5	-2.1	-0.7	-2.3	-0.8	-2.5	-1.9	-0.9	-0.3	-0.5	-2.7	-1.0	-0.5
Respiratory disease	0.8	1.8	6.1	1.4	0.2	1.7	1.7	1.4	0.9	-0.2	-0.5	0.7	1.0	1.6	2.5
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.0	0.7	1.0	1.4	0.9	1.0	1.4	1.0	0.5	0.6	0.8	0.6	0.9
Average weekly fortified wine intake	0.8	0.9	4.2	-0.0	2.0	-1.7	0.3	0.3	1.3	-0.2	1.1	0.7	0.0	0.7	-0.1
Trunk fat mass	0.8	3.4	9.0	-1.7	-2.8	-0.9	1.1	-1.9	-1.6	-3.0	-0.7	-1.1	-2.9	-1.8	0.1
Illnesses of mother	0.8	1.0	2.5	1.5	-0.5	0.7	-0.4	0.7	0.8	-0.5	-0.6	-1.0	1.6	1.2	-1.5
Ever highly irritable/argumentative for 2 days	0.8	1.0	3.4	0.1	-1.3	0.8	1.9	-0.2	-1.1	-1.6	-1.4	-0.4	-0.2	-0.1	0.4
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	4.5	-1.6	-0.1	-1.9	-0.1	-1.8	-1.2	-1.2	-0.4	0.3	-2.1	-1.2	0.8
Comparative body size at age 10	0.8	2.3	5.2	0.9	1.9	1.0	2.3	0.9	1.8	1.0	2.3	1.3	0.3	1.3	1.9
Medication: Ibuprofen	0.8	1.0	3.7	-0.3	0.4	-0.8	-1.9	0.2	0.9	1.5	1.4	-0.6	-0.3	-0.8	-1.1
Whole body fat mass	0.8	3.4	9.5	-2.0	-2.6	-1.1	0.7	-2.0	-1.4	-2.8	-0.3	-0.9	-3.1	-1.9	0.1
Leg pain on walking	0.8	1.0	3.0	-1.3	-0.3	-1.4	0.3	-1.4	-0.5	0.7	-0.5	-0.2	-1.7	-1.5	-0.4
Medication: Gliclazide	0.8	0.9	1.8	-1.1	-1.1	-1.3	-0.7	-1.0	-1.3	-1.2	-0.4	-0.6	-1.0	-0.2	-0.9
Guilty feelings	0.8	1.2	3.7	-0.9	-1.9	0.5	0.4	-0.8	-0.8	-1.9	-1.7	-0.4	-1.3	-0.2	0.4
Mother’s age at death	0.8	1.0	4.5	0.0	1.4	-0.2	0.6	1.1	1.0	0.6	0.1	2.1	0.2	0.1	1.5
Myopia	0.8	1.2	3.5	-1.4	-1.3	0.6	-0.1	-0.7	-1.0	-1.0	-1.9	-0.5	-1.2	-0.9	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	6.3	-0.4	0.4	-0.7	-2.5	0.5	0.5	0.6	0.1	2.0	-0.1	0.3	0.2
Leg fat mass (left)	0.8	3.2	8.9	-2.0	-2.6	-1.0	0.8	-1.8	-1.3	-2.4	0.5	-1.2	-3.0	-2.1	-0.0
Bipolar Disorder or Schizophrenia	0.7	1.6	6.2	1.8	0.2	2.0	-0.5	1.7	0.9	1.3	0.1	0.2	2.5	0.5	0.5
Blood Red Count	0.7	7.0	15.0	2.7	3.2	1.7	0.8	1.9	2.8	3.9	3.0	3.8	2.1	2.6	1.6
High blood pressure	0.7	2.1	4.8	-1.8	-1.2	-1.3	-0.9	-2.2	-1.6	-1.2	-0.8	-1.0	-2.0	-1.4	-1.1
Stomach or abdominal pain in last month	0.7	0.9	1.8	0.6	1.0	0.2	-1.2	1.3	0.5	1.3	1.3	0.7	0.9	0.5	0.7
Past tobacco smoking	0.7	1.3	3.3	-1.8	-0.1	-1.5	-1.2	-1.1	-1.4	-0.7	-1.4	0.9	-1.1	-1.0	-0.6
Qualifications: None of the above	0.7	1.6	4.3	-1.4	-0.6	-1.6	1.2	-1.5	-1.0	-0.8	-0.2	0.6	-2.1	-1.8	1.0
Arm fat percentage (right)	0.7	2.9	10.6	-2.0	-2.1	-0.8	1.6	-1.9	-1.2	-1.5	0.4	-0.3	-3.3	-2.2	0.4
Medication: Cholesterol lowering	0.7	1.1	2.8	-1.2	0.1	-0.7	0.1	-1.3	-1.3	0.2	0.4	0.9	-1.7	-1.4	1.4
Medication: Lansoprazole	0.7	0.8	2.4	-1.1	-0.7	-0.7	-1.5	-0.8	-0.2	-0.4	0.6	-1.0	-1.2	-0.8	-0.8
Prospective memory result	0.7	0.8	1.8	-1.3	-0.7	-1.0	-0.4	-0.7	-1.3	-0.5	-1.1	0.1	-1.3	-1.2	0.2
Pulse wave reflection index	0.7	0.8	2.1	-0.7	-1.4	-0.4	0.9	-1.2	-0.8	-0.9	-1.1	-0.0	-0.8	-0.4	-1.3
Loud music exposure frequency	0.7	0.7	1.8	1.3	1.1	0.7	1.3	0.3	0.4	0.2	-0.3	0.5	1.2	0.7	1.1
Age at last live birth	0.7	1.0	2.2	-1.5	-1.1	-0.1	0.6	-1.0	-0.5	-0.1	-1.4	-0.9	-1.4	-1.0	-0.4
Smoking status: Previous	0.7	1.1	2.8	1.7	0.0	1.3	1.2	1.2	1.0	0.2	1.2	-0.2	1.2	0.8	1.0
Arm fat percentage (left)	0.7	2.6	8.7	-1.8	-2.1	-0.6	1.7	-1.6	-1.0	-1.8	0.4	-0.4	-3.0	-2.1	0.3
Qualifications: nursing, teaching	0.7	1.2	4.0	1.1	1.4	0.3	0.1	1.2	0.7	1.4	-0.1	0.3	1.7	2.0	0.0
Asthma (self-reported)	0.7	1.4	6.1	1.0	0.9	1.4	1.9	1.0	0.7	0.1	0.3	0.7	0.7	0.9	2.5
Medication: Atorvastatin	0.7	0.9	2.3	-1.3	-1.2	-0.2	-0.1	-0.6	-1.4	-0.6	-0.9	0.9	-0.8	-1.5	-0.0
Ever depressed for a whole week	0.7	0.9	4.4	0.3	-0.2	1.8	-0.1	0.7	-0.9	-0.3	-2.1	0.4	0.4	-0.2	1.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.2	0.8	-1.0	-0.2	0.9	0.6	-0.4	1.2	1.6	1.1	0.2	-0.1	1.8
Crohns Disease (2017)	0.6	1.3	3.1	1.0	1.4	-1.5	-1.2	0.7	0.1	0.2	0.5	0.9	1.6	1.3	-1.8
Hypothyroidism (self reported)	0.6	1.3	4.0	-1.4	-0.4	-1.6	0.2	-1.5	-1.2	-1.1	-1.1	-0.2	-2.0	-0.8	0.8
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.6	-1.0	-1.2	-0.6	-1.6	-0.4	-0.1	-0.8	0.1	-1.3	-1.3	-0.3	-0.6
Relative age voice broke	0.6	0.8	3.1	1.8	0.0	1.1	0.8	0.8	-0.4	0.1	-0.1	0.5	1.3	1.0	1.2
Qualifications: CSEs or equivalent	0.6	0.8	2.4	-0.6	-1.1	-0.0	1.0	-0.9	-0.6	-1.6	-0.6	-0.3	-1.4	-0.6	0.4
Serious illness, injury or assault to yourself	0.6	0.7	2.6	0.4	-0.4	-0.7	-1.6	-0.1	-0.4	-1.2	0.5	1.2	0.5	1.3	0.5
Father’s age at death	0.6	0.8	3.2	-0.1	1.0	-0.5	0.1	-0.2	1.5	0.2	1.8	1.7	0.4	0.3	-0.5
Asthma	0.6	1.1	4.3	1.1	0.6	1.2	1.8	0.9	0.8	0.3	0.2	0.3	0.7	0.9	2.1
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	3.6	-0.6	-0.2	-0.9	-1.9	-0.7	-0.8	-0.3	0.5	0.7	-1.3	-0.2	0.6
Blood clot in the leg (DVT)	0.6	0.8	3.4	0.7	-1.2	-0.2	0.8	0.4	-0.6	0.8	1.2	1.0	-0.0	-0.3	1.9
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.8	-0.6	-0.9	-1.3	-0.8	-0.2	-1.2	-1.4	-0.5	-0.9	-0.5	0.0	-0.3
Migraine (self-reported)	0.6	0.7	1.8	-1.0	-0.7	-0.9	-0.6	-0.8	-0.4	-0.4	-1.1	-0.3	-1.4	-1.2	0.1
Commuting to job workplace: Car/motor vehicle	0.6	0.7	3.0	0.1	-0.8	1.3	1.1	0.8	0.4	1.7	0.1	-0.2	0.2	0.2	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.6	1.3	0.5	0.1	-0.6	1.4	0.3	0.4	0.5	0.0	1.6	0.2	-0.7
Commuting to job workplace: Walk	0.6	0.6	3.6	0.0	1.3	0.6	1.9	0.3	0.2	-0.4	-0.2	0.7	-0.3	-0.0	0.9
Wears glasses or contact lenses	0.6	0.6	1.4	-1.1	0.0	-0.8	1.0	-0.7	-0.4	-0.2	-1.0	0.0	-1.0	-1.2	-0.9
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.9	0.0	-0.8	1.1	0.4	-0.0	-0.1	1.7	-0.3	0.2	-0.3	-1.4	1.6
Commuting to job workplace: Cycle	0.6	0.7	2.2	1.1	-0.5	1.1	0.7	0.1	0.4	0.1	-0.0	-1.5	1.4	0.5	-1.1
Pain experienced in last month	0.6	1.0	3.0	1.3	0.8	0.5	-0.3	0.8	0.5	-1.0	-1.5	-0.2	1.6	1.7	-0.5
Basal cell carcinoma (self-reported)	0.6	0.7	3.4	1.7	0.4	0.3	-0.0	0.5	-0.2	0.1	1.1	-0.6	1.8	0.0	0.2
Prostate Cancer	0.5	0.7	2.8	0.4	-0.0	1.1	0.9	0.6	0.3	0.5	1.7	1.4	0.5	-0.6	0.5
Body Mass Index (BMI) (2010)	0.5	0.7	2.4	-0.8	-1.5	-0.2	0.6	-1.1	-1.1	-0.1	0.4	-0.8	-0.9	-1.1	-0.0
Rheumatoid Arthritis	0.5	0.6	2.1	-0.4	-0.5	-0.6	0.7	-0.1	0.7	-0.3	1.0	1.2	-0.8	-0.7	1.5
Height	0.5	9.6	33.3	-1.6	-3.7	-0.7	-1.9	-2.2	-3.1	-4.8	-5.8	-3.9	-0.9	0.3	-2.9
Lung FEV1/FVC ratio	0.5	2.4	11.4	-1.3	0.3	0.4	2.5	-1.3	-1.3	-0.3	-1.8	-0.5	-1.5	-3.4	-0.6
Hearing difficulty/problems: Yes	0.5	0.7	2.7	-0.7	-0.5	-0.4	-1.1	0.4	-1.5	-0.9	-1.6	-0.6	-0.4	0.2	0.1
Ever had hysterectomy (womb removed)	0.5	0.6	2.0	-0.9	0.3	-1.4	-0.4	-0.5	-0.8	-0.4	-0.8	-0.8	-0.9	-1.1	-0.0
Angina	0.5	0.7	4.7	-0.4	-0.4	-0.6	2.2	-0.5	-0.7	0.6	-0.6	-0.3	-0.6	-0.7	0.3
Age when periods started (menarche)	0.5	1.2	5.4	-0.4	0.8	1.0	0.2	-0.2	0.0	0.5	-2.3	2.3	-0.3	0.6	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.3	-0.4	-0.5	-1.8	-1.5	-1.8	-0.9	-1.3	0.2	-1.0	-0.6	-0.3	-1.2
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	5.8	-0.2	-0.3	0.4	0.3	-0.4	-0.5	-0.0	0.0	0.7	-0.3	-0.1	2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.9	-0.8	-0.4	-1.4	-1.3	-1.5	-0.6	-0.3	-0.2	-1.4	-0.8	-0.4	-1.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.8	-0.1	-1.0	1.3	0.2	0.6	-0.5	-1.3	-1.3	-0.1	0.3	0.3	0.5
Falls in the last year	0.5	0.7	2.7	-0.3	-0.6	-0.1	0.9	-1.1	-0.7	0.7	0.2	-0.4	-0.8	-1.6	1.1
Mouth/teeth dental problems: Dentures	0.5	0.8	5.0	-0.2	-0.6	0.3	0.6	-0.7	-0.9	0.1	0.1	0.2	-1.3	-1.0	2.2
High blood pressure (siblings)	0.5	0.8	2.2	1.0	0.3	0.8	0.2	1.4	0.1	0.9	0.5	0.9	0.7	1.0	1.5
Exposure to tobacco smoke outside home	0.5	0.7	2.5	-0.9	-0.1	-0.7	0.1	-1.3	-0.5	0.1	-0.5	-0.7	-0.8	-1.6	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	3.4	0.3	0.1	-0.7	-0.6	0.7	1.1	0.5	0.6	0.6	0.2	1.8	-0.2
Angina (self-reported)	0.5	0.6	5.7	-0.2	-0.4	-0.3	2.4	-0.2	-0.6	0.5	-0.5	0.0	-0.5	-0.4	0.7
Medication: Seretide 50 evohaler	0.5	0.5	1.6	-0.2	-0.4	0.4	1.2	-0.8	-1.2	-0.2	0.4	-0.6	-0.4	-1.3	-0.2
Mean time to correctly identify matches	0.5	1.0	2.8	-1.2	-1.2	-1.5	-1.0	-1.4	-0.4	-0.5	0.5	-0.4	-1.7	-0.9	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.1	0.1	0.2	-0.4	-1.2	0.4	-0.7	-1.1	0.2	1.5	-0.2	0.1	1.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.0	-0.2	0.8	0.9	0.2	0.7	0.2	1.2	-1.0	0.7	-0.5	-0.2	1.4
Supplements: Vitamin C	0.5	0.6	3.1	0.7	0.1	0.8	0.5	0.5	-0.2	-0.1	-1.8	-0.0	0.3	0.2	1.6
Knee pain experienced in last month	0.5	0.8	1.8	-0.0	0.6	-0.1	1.3	1.2	1.1	0.9	0.7	1.3	-0.3	-0.4	1.0
Ever taken oral contraceptive pill	0.5	0.5	2.1	0.6	0.3	0.9	-0.5	0.7	1.0	1.4	-0.2	0.7	0.6	0.5	-0.1
Cholesterol lowering medication	0.5	0.8	2.5	-0.6	-0.8	-1.0	-1.6	-0.8	-0.8	-0.9	0.9	-0.3	-0.7	0.2	-1.1
Bipolar Disorder (2018)	0.4	0.6	5.6	0.5	-0.2	0.0	-2.4	0.2	0.0	0.4	-0.1	-0.2	1.1	-0.2	-0.1
Intelligence (Savage-Jansen 2018)	0.4	1.2	4.8	-0.0	1.2	-0.5	-1.5	0.2	1.2	1.3	0.7	-0.1	1.0	0.7	-2.2
Alzheimer’s Disease (including proxy)	0.4	0.5	1.6	-0.3	0.7	-0.4	-1.3	0.8	0.9	0.8	-0.0	1.0	-0.3	-0.0	0.8
Blood Platelet Count	0.4	4.3	12.2	-2.6	-1.3	-3.5	-1.7	-2.6	-0.4	-0.5	0.5	-1.9	-2.7	-0.7	-2.9
Smoking Status	0.4	1.0	6.7	0.8	-1.0	0.2	-0.3	-0.2	0.2	-0.6	-0.1	-2.6	0.9	0.3	-1.5
Medication: Co-codamol	0.4	0.4	1.8	-0.4	-0.3	0.1	-1.4	0.0	0.5	0.7	1.3	-0.1	-0.1	-0.6	-0.5
Medication: Atenolol	0.4	0.5	3.7	0.6	0.2	-0.2	0.0	0.1	-0.2	0.6	1.9	1.1	0.4	0.1	0.5
Sitting height	0.4	2.5	12.2	0.0	-1.4	0.5	-0.8	-0.2	-0.5	-1.9	-3.5	-2.4	0.3	1.6	-1.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	3.7	-0.0	0.3	0.5	0.5	0.2	-0.7	-0.2	-1.9	-0.3	0.3	0.2	0.3
Pain all over the body in last month	0.4	0.5	3.1	0.6	0.3	0.5	1.1	0.3	0.2	0.6	0.3	0.1	-0.1	0.2	1.8
Hair/balding pattern: Pattern 3	0.4	0.7	2.4	0.9	0.9	0.2	0.9	0.9	-0.2	1.0	0.2	1.0	0.6	-0.2	1.6
Arm fat mass (right)	0.4	1.6	5.4	-1.3	-1.6	-0.6	1.9	-1.0	-0.4	-1.6	0.5	-0.4	-2.3	-1.3	0.5
Standing height	0.4	3.5	14.2	-0.5	-2.2	0.1	-1.0	-0.2	-1.1	-3.5	-3.8	-2.3	-0.1	1.1	-1.5
Glaucoma (self-reported)	0.4	0.4	1.9	-0.5	0.5	-0.4	-0.5	-0.3	0.4	0.9	1.0	-0.1	-0.0	0.5	-1.4
Gout (self-reported)	0.4	0.5	2.0	0.1	-1.4	-0.9	-0.4	-0.8	-1.2	-0.7	-0.1	-0.2	-0.2	-0.8	-0.5
Number of full brothers	0.4	0.5	1.4	1.0	0.2	0.9	-0.4	0.5	0.2	0.7	1.2	0.5	1.2	-0.3	0.7
Medication: Blood pressure	0.4	0.7	3.6	-0.2	0.1	0.3	-0.6	-0.3	-0.7	-0.8	-0.7	1.1	-0.7	-0.7	1.9
Medication: Allopurinol	0.4	0.5	1.3	-0.1	-1.1	-1.1	-1.1	-0.6	-1.0	-0.6	0.1	-0.4	-0.2	-0.5	-0.8
Suffer from ‘nerves’	0.4	0.6	1.8	0.4	-0.0	-1.2	-1.3	-0.2	-0.8	0.1	-1.3	-0.5	-0.1	0.1	0.9
Medication: Aspirin	0.4	0.6	3.0	-0.2	-0.9	-1.7	-0.2	-0.6	-1.0	-0.8	0.0	-0.4	-0.4	-0.6	0.4
Illnesses of father: Heart disease	0.4	0.6	3.0	-0.0	-0.3	0.1	-0.6	-0.6	-0.1	-0.9	-1.3	-1.7	-0.1	-0.4	-0.7
Diabetes diagnosed by doctor	0.4	0.7	2.8	-0.7	-1.2	0.3	0.6	-0.5	-1.1	-0.7	0.4	0.3	-0.9	-0.5	1.7
Medication: Aspirin	0.4	0.5	2.7	-0.1	-0.7	-1.7	0.3	-1.0	-1.1	-0.4	0.1	-0.2	-0.4	-0.0	0.4
Arm fat mass (left)	0.4	1.6	4.9	-1.1	-1.5	-0.3	2.1	-0.9	-0.2	-1.5	0.6	-0.4	-2.2	-1.4	0.4
Unable to work because of sickness or disability	0.4	0.5	2.5	0.0	-1.2	-0.6	-0.7	0.2	-1.6	-0.8	-0.1	0.4	0.2	-0.0	0.4
Heart disease (siblings)	0.4	0.5	2.2	-0.2	-0.5	-0.8	-1.5	-0.4	-0.5	-0.4	0.6	0.2	-0.2	-1.3	-0.4
Alzheimer’s Disease (in mother)	0.3	0.4	2.4	-0.6	0.4	-0.4	-0.4	0.3	-0.2	0.3	-1.5	0.5	-0.4	-0.3	0.8
Major Depression (MDD)	0.3	0.4	1.8	-0.0	-0.9	0.0	-1.4	-0.6	0.1	-0.4	0.5	0.1	0.7	-0.7	-0.6
Triglycerides	0.3	0.6	2.1	0.3	-0.1	0.6	-0.8	1.4	-0.4	0.5	-0.2	0.7	0.3	1.4	0.8
Ulcerative Colitis	0.3	0.4	1.5	-0.1	-0.5	-0.5	0.6	-0.3	-0.4	-0.6	-1.2	-0.7	0.4	0.0	-1.2
Blood White Count	0.3	2.5	9.0	0.7	0.5	-2.8	-1.4	0.1	0.4	1.6	0.8	-2.0	0.8	1.4	-3.0
BMI	0.3	1.9	6.4	-0.8	-0.7	-0.9	2.5	-0.8	0.6	0.9	2.1	0.8	-1.9	-1.5	1.4
Systolic Blood Pressure	0.3	1.5	9.7	0.3	-0.9	-1.9	-3.1	-0.3	-1.2	-0.9	0.3	0.3	-0.2	0.3	-0.9
Type 2 Diabetes (T2D) (2018)	0.3	0.5	2.3	-0.6	-1.5	0.1	-0.1	-0.2	-0.9	-1.0	0.2	0.5	-0.7	0.4	1.0
Supplements: Zinc	0.3	0.3	0.8	-0.4	0.5	-0.9	0.1	0.2	0.7	-0.4	0.3	0.5	-0.7	0.1	0.8
Medication: Metformin	0.3	0.5	1.0	-0.9	-0.9	-0.1	-0.7	-0.3	-1.0	-0.9	0.4	0.5	-0.8	-0.3	0.7
Body mass index (BMI)	0.3	1.4	5.0	-0.8	-0.7	-0.5	2.2	-0.7	0.3	-0.6	1.9	0.1	-1.8	-1.4	0.9
Allergy	0.3	0.8	5.2	0.2	0.7	-0.4	-1.3	0.0	0.2	0.6	0.3	-1.2	0.4	-0.0	-2.3
Diabetes (self-reported)	0.3	0.4	1.6	-0.5	-0.6	1.0	1.0	-0.3	-0.3	-0.5	0.3	0.6	-0.4	0.1	1.3
Medication: Ramipril	0.3	0.4	2.0	0.7	-0.1	-0.2	0.2	0.7	-0.5	-1.4	-0.6	0.2	0.4	-0.2	1.0
Illnesses of siblings	0.3	0.4	1.3	0.2	-0.2	0.4	1.1	-0.2	0.3	-0.3	-0.9	-1.1	0.4	-0.4	-0.6
Weight	0.3	1.5	5.3	-1.0	-1.8	-0.4	1.5	-0.8	-0.5	-2.3	0.0	-0.9	-1.7	-1.0	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.7	0.5	0.4	-0.7	-0.8	0.4	0.7	-0.5	-0.4	-0.2	0.5	0.6	-0.5
Lung cancer (father)	0.3	0.3	1.5	-0.3	0.4	-1.2	0.3	-0.5	-0.9	-0.5	0.1	-0.4	0.2	-0.3	-0.6
Medication: Amlodipine	0.3	0.4	1.1	-0.8	-0.8	-0.6	0.6	-0.4	-0.3	-0.4	-0.6	-0.3	-0.9	0.0	-1.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.4	0.1	0.2	-0.6	-0.7	0.6	0.7	0.3	1.1	0.4	0.1	-0.7	1.2
Number of children fathered	0.3	0.4	1.7	0.8	-0.0	0.6	0.6	0.4	1.3	0.0	0.6	-0.4	0.7	0.4	-0.4
Age at first live birth	0.3	0.5	2.1	-1.0	0.4	0.1	0.9	-0.7	0.2	0.6	-1.4	-0.0	-0.6	0.4	-0.7
Shortness of breath walking on level ground	0.3	0.4	0.9	-1.0	0.1	0.6	0.2	-0.4	0.7	-0.2	-0.8	-0.5	-0.7	-0.6	-0.7
Heart disease (mother)	0.3	0.4	1.7	-1.3	-0.1	0.3	-0.7	-0.4	-0.3	-0.6	-0.4	0.3	-1.1	-0.7	-0.1
Pulse rate, automated reading	0.3	1.0	4.4	-0.5	1.1	-1.3	0.5	-0.1	-0.6	-0.1	-1.2	1.0	-1.1	0.8	2.1
Alcohol intake frequency.	0.3	0.7	2.2	-0.4	1.1	0.9	0.8	-0.3	-0.4	-0.0	-0.9	1.0	-1.0	-0.2	1.5
Comparative height size at age 10	0.3	1.4	8.6	0.6	-0.7	0.2	1.7	0.8	-0.1	-2.9	-1.5	-0.8	0.6	0.5	0.7
Breast cancer (self-reported)	0.3	0.4	1.5	0.4	-0.1	-0.5	-1.1	0.2	0.0	-0.7	-0.1	1.2	0.2	0.9	-0.5
Alcohol drinker status: Never	0.3	0.4	1.4	0.3	-0.1	0.0	0.8	0.8	0.7	-0.4	-1.2	-0.6	0.6	0.7	-0.2
Average weekly beer plus cider intake	0.3	0.5	2.4	-0.0	-1.5	0.4	1.1	0.1	-0.5	0.1	0.1	-1.2	-0.3	0.1	-0.6
Supplements: Calcium	0.3	0.3	1.3	0.3	0.8	-0.6	-0.1	0.1	1.1	0.3	1.1	0.0	0.6	-0.4	-0.2
Schizophrenia vs Biploar Disorder	0.2	0.3	1.1	0.2	0.1	0.5	1.0	0.7	0.9	0.5	-0.1	0.8	0.2	-0.2	0.3
Irritable Bowel Disease (IBD)	0.2	0.5	3.3	0.2	0.6	-1.2	-0.5	-0.2	-0.1	0.3	0.1	0.4	0.8	0.3	-1.8
Ulcerative Colitis (UC)	0.2	0.3	0.8	-0.6	-0.7	-0.2	0.4	-0.9	-0.5	0.3	-0.5	-0.2	-0.5	-0.8	-0.8
Allergy or Eczema	0.2	0.5	2.9	-0.3	0.2	0.7	0.3	-0.1	-0.0	0.5	-0.8	1.7	-0.4	0.4	1.0
Leg fat-free mass (left)	0.2	0.9	5.8	0.2	-0.6	0.5	2.4	0.5	0.8	-1.6	0.2	-0.5	-0.2	0.1	0.6
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.8	-0.5	0.0	0.4	0.5	-0.4	-0.2	-0.4	-0.6	1.3	-0.3	0.5	1.1
Leg predicted mass (left)	0.2	0.9	5.5	0.2	-0.6	0.6	2.3	0.5	0.8	-1.6	0.2	-0.5	-0.3	0.1	0.6
Had menopause	0.2	0.2	0.8	0.1	-0.6	-0.7	-0.4	0.1	-0.5	-0.9	0.3	-0.0	0.2	-0.7	0.4
Had other major operations	0.2	0.3	1.1	0.4	0.8	0.1	-0.3	0.2	-1.0	-0.1	-0.1	0.4	0.2	0.5	1.1
Financial difficulties in last 2 years	0.2	0.3	1.7	0.3	-0.1	-0.5	-0.1	1.3	-0.2	-0.3	0.1	-0.4	0.4	0.5	-0.8
Trunk fat-free mass	0.2	1.1	3.4	0.7	-0.0	0.6	1.8	1.6	1.5	-1.1	-0.5	-0.3	0.8	1.2	0.5
Hip circumference	0.2	1.0	2.4	-0.5	-1.1	0.7	1.5	-0.5	0.2	-1.4	1.3	0.6	-1.4	-1.1	1.1
Trunk predicted mass	0.2	1.1	3.3	0.7	-0.0	0.7	1.8	1.6	1.5	-1.0	-0.4	-0.3	0.8	1.2	0.5
Arm fat-free mass (right)	0.2	1.2	4.3	0.8	0.0	0.9	2.1	1.6	1.7	-1.0	0.4	-0.3	0.9	1.0	0.5
Arm predicted mass (right)	0.2	1.2	4.4	0.9	-0.1	0.8	2.1	1.6	1.7	-1.2	0.2	-0.4	0.9	1.0	0.5
Whole body fat-free mass	0.2	1.0	4.5	0.7	-0.1	0.7	2.1	1.4	1.4	-1.1	-0.0	-0.5	0.6	0.9	0.5
Leg fat-free mass (right)	0.2	1.3	8.9	0.7	-0.2	0.9	3.0	1.0	1.4	-1.2	0.4	-0.5	0.3	0.6	0.8
Whole body water mass	0.2	1.0	4.5	0.7	-0.1	0.6	2.1	1.4	1.5	-1.1	0.0	-0.4	0.6	0.9	0.5
Leg predicted mass (right)	0.2	1.3	8.6	0.7	-0.2	0.9	2.9	1.0	1.4	-1.2	0.3	-0.5	0.3	0.7	0.7
Average weekly champagne plus white wine intake	0.2	0.3	1.1	-0.0	0.7	-0.3	0.2	-0.1	0.8	0.9	-0.3	-0.6	0.5	-0.5	-1.1
Arm fat-free mass (left)	0.2	0.9	3.0	0.7	0.0	0.3	1.7	1.4	1.6	-0.7	0.6	-0.5	0.5	0.9	0.3
Diastolic blood pressure, automated reading	0.2	0.6	2.8	1.0	0.1	-0.9	-0.5	0.0	-0.7	0.2	0.5	0.7	-0.2	0.6	1.7
Arm predicted mass (left)	0.2	0.8	3.0	0.7	0.1	0.4	1.7	1.4	1.4	-0.8	0.5	-0.1	0.4	1.0	0.7
Blood Eosinophil Count	0.1	0.9	4.0	0.2	-0.7	-0.8	1.0	-0.5	-2.0	-1.5	-0.8	-0.9	0.5	-0.3	-0.5
Heel T-Score	0.1	0.8	4.4	-0.4	0.0	-2.1	-0.8	-1.0	0.1	-1.5	-0.2	0.8	-0.5	0.0	0.7
Hair Pigment	0.1	1.5	3.8	1.2	0.1	1.4	0.3	1.9	1.2	1.4	0.4	1.6	0.9	0.9	1.8
Tanning	0.1	1.2	3.3	-0.6	-1.3	-0.5	-0.9	-1.3	-0.8	-1.1	-1.8	-1.3	-0.8	-0.6	-1.3
Relative age of first facial hair	0.1	0.2	0.9	0.1	0.1	0.1	-0.6	-0.4	-0.7	0.8	-0.3	0.1	-0.5	0.2	0.9
Systolic blood pressure, automated reading	0.1	0.4	1.4	0.9	-0.5	-0.8	-1.2	0.1	-0.6	0.6	0.6	0.4	0.1	0.4	0.1
Heart attack	0.1	0.2	0.8	0.2	0.2	0.3	0.9	0.2	0.2	-0.8	0.5	0.2	-0.3	-0.1	0.3
Hearing aid user	0.1	0.1	0.5	-0.1	0.0	0.1	-0.3	0.3	-0.7	0.2	-0.4	-0.4	-0.0	0.1	0.6
Basal metabolic rate	0.1	0.8	4.1	0.3	-0.5	0.4	2.0	0.9	1.1	-1.5	0.0	-0.6	0.0	0.5	0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.5	-0.3	-0.0	0.0	0.7	-0.2	0.1	-0.6	0.4	-0.2	-0.6	-0.4	-0.2

Hub : Genes

PPP1R21

Models

Trait associations