[Hub]/) : Traits : Lung FVC : ← →

chr2:134,513,621-137,435,625

Best TWAS P=4.32e-17 · Best GWAS P=8.7e-16 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CCNT2	0.12	0.11	lasso	2	0.10	9.8e-13	5.5	5.4	6.5e-08	0.45	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LOC100129961	0.17	0.14	enet	9	0.14	2.6e-17	-7.1	-7.2	8.4e-13	-0.48	0.11	0.89	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TMEM163	0.05	0.02	lasso	7	0.01	5.9e-03	3.1	-5.4	7.0e-08	-0.43	0.26	0.24	FALSE
4	GTEx	Adipose Subcutaneous	DARS	0.08	0.01	lasso	6	0.01	6.8e-02	6.9	7.4	1.5e-13	0.66	0.11	0.19	FALSE
5	GTEx	Artery Aorta	MCM6	0.11	0.04	enet	17	0.08	2.0e-05	6.9	7.2	7.6e-13	0.78	0.12	0.73	FALSE
6	GTEx	Artery Aorta	CCNT2	0.12	0.12	lasso	3	0.11	1.9e-06	5.5	5.5	5.0e-08	0.45	0.41	0.48	FALSE
7	GTEx	Artery Tibial	MCM6	0.12	0.03	enet	19	0.08	1.1e-06	3.6	6.2	6.8e-10	0.67	0.06	0.82	TRUE
8	GTEx	Brain Cerebellar Hemisphere	AC016725.4	0.27	0.18	lasso	4	0.24	8.3e-07	5.5	-5.2	2.1e-07	-0.42	0.17	0.62	FALSE
9	GTEx	Breast Mammary Tissue	DARS	0.13	0.00	lasso	7	0.00	5.8e-01	6.1	6.6	3.2e-11	0.52	0.04	0.29	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	AC016725.4	0.35	0.02	lasso	14	0.03	4.7e-02	2.6	-6.9	5.0e-12	-0.40	0.05	0.33	FALSE
11	GTEx	Esophagus Mucosa	DARS	0.12	0.05	lasso	4	0.04	9.0e-04	6.6	6.8	1.0e-11	0.57	0.36	0.25	FALSE
12	GTEx	Esophagus Muscularis	DARS	0.12	0.11	lasso	3	0.09	3.5e-06	6.6	6.7	2.3e-11	0.57	0.86	0.12	FALSE
13	GTEx	Lung	DARS	0.07	0.05	lasso	4	0.05	5.8e-05	6.7	6.7	1.8e-11	0.57	0.89	0.02	FALSE
14	GTEx	Nerve Tibial	MCM6	0.09	0.09	lasso	4	0.09	4.5e-07	4.7	6.3	2.5e-10	0.63	0.35	0.45	TRUE
15	GTEx	Nerve Tibial	DARS	0.13	0.06	lasso	5	0.05	3.2e-04	6.6	6.6	3.5e-11	0.59	0.65	0.03	FALSE
16	GTEx	Nerve Tibial	AC016725.4	0.15	0.06	lasso	6	0.02	8.1e-03	5.5	-5.3	9.5e-08	-0.45	0.81	0.12	TRUE
17	GTEx	Ovary	DARS	0.28	0.12	lasso	5	0.11	1.1e-03	5.2	5.3	1.2e-07	0.43	0.12	0.25	FALSE
18	GTEx	Prostate	AC016725.4	0.27	0.03	enet	23	0.13	4.6e-04	-7.3	-6.5	6.7e-11	-0.45	0.04	0.90	FALSE
19	GTEx	Skin Not Sun Exposed Suprapubic	DARS	0.15	0.11	enet	4	0.10	3.0e-06	6.7	6.8	8.1e-12	0.57	0.89	0.02	FALSE
20	GTEx	Skin Sun Exposed Lower leg	DARS	0.10	0.12	lasso	1	0.11	1.7e-09	6.7	6.7	2.3e-11	0.56	0.98	0.01	FALSE
21	GTEx	Testis	CCNT2	0.31	0.26	lasso	6	0.26	9.3e-12	5.5	5.2	2.5e-07	0.38	1.00	0.00	FALSE
22	GTEx	Testis	AC016725.4	0.18	0.09	lasso	6	0.09	6.3e-05	-7.1	7.0	2.2e-12	0.47	0.03	0.96	FALSE
23	GTEx	Thyroid	MCM6	0.06	0.01	lasso	3	0.02	4.9e-03	7.8	7.1	1.4e-12	0.65	0.04	0.84	FALSE
24	GTEx	Thyroid	CCNT2	0.09	0.10	lasso	2	0.09	1.8e-07	5.5	5.5	3.1e-08	0.42	0.97	0.01	FALSE
25	GTEx	Thyroid	DARS	0.20	0.13	lasso	3	0.15	1.3e-11	6.6	6.8	8.5e-12	0.58	0.99	0.01	FALSE
26	METSIM	Adipose	DARS	0.09	0.07	blup	311	0.09	4.6e-13	6.9	5.3	1.4e-07	0.44	0.97	0.03	FALSE
27	NTR	Blood	CCNT2	0.01	0.00	blup	370	0.00	6.7e-02	5.4	6.5	9.1e-11	0.50	0.16	0.41	FALSE
28	NTR	Blood	MCM6	0.02	0.02	lasso	2	0.03	1.2e-08	7.3	7.8	7.4e-15	0.67	0.54	0.46	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	CCNT2	0.06	0.03	enet	27	0.05	1.6e-06	5.5	6.9	4.3e-12	0.53	0.04	0.96	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	TMEM163	0.19	0.16	lasso	14	0.23	6.2e-29	2.4	-5.4	5.5e-08	-0.40	0.99	0.01	FALSE
31	YFS	Blood	CCNT2	0.01	0.01	blup	363	0.01	6.3e-05	5.5	7.6	2.9e-14	0.61	0.11	0.84	FALSE
32	YFS	Blood	DARS	0.17	0.19	enet	36	0.19	8.2e-60	6.9	7.8	6.7e-15	0.58	0.95	0.05	TRUE
33	YFS	Blood	MCM6	0.18	0.15	enet	20	0.20	8.5e-64	7.6	8.4	4.3e-17	0.68	0.07	0.93	TRUE
34	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LCT	0.07	0.04	blup	36	0.04	5.0e-04	4.7	-7.0	3.7e-12	-0.50	0.01	0.42	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	LCT	0.02	0.02	enet	3	0.03	7.6e-07	7.6	-7.6	3.4e-14	-0.67	0.00	1.00	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM163	0.06	0.09	lasso	7	0.08	1.6e-16	5.6	-5.4	5.4e-08	-0.41	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ZRANB3	0.08	0.01	lasso	11	0.00	1.9e-01	5.5	-5.2	2.0e-07	-0.40	0.06	0.36	FALSE
38	The Cancer Genome Atlas	Colon Adenocarcinoma	ZRANB3	0.06	0.05	blup	118	0.06	3.5e-04	5.2	-5.2	1.6e-07	-0.42	0.18	0.76	FALSE
39	The Cancer Genome Atlas	Glioblastoma Multiforme	LCT	0.16	0.08	blup	36	0.10	5.3e-04	7.3	-7.2	6.0e-13	-0.63	0.00	0.90	FALSE
40	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DARS	0.04	0.05	lasso	2	0.05	3.5e-06	6.5	6.5	5.8e-11	0.56	0.02	0.98	FALSE
41	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZRANB3	0.05	0.06	blup	118	0.04	2.5e-05	5.1	-5.3	1.1e-07	-0.40	0.17	0.83	FALSE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ACMSD	0.04	0.01	blup	46	0.02	2.2e-03	5.5	7.0	3.5e-12	0.50	0.04	0.72	FALSE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DARS	0.10	0.08	enet	14	0.11	5.5e-12	6.4	6.2	5.9e-10	0.54	0.02	0.98	FALSE
44	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LCT	0.04	0.02	blup	36	0.02	1.9e-03	7.3	-8.2	1.8e-16	-0.69	0.00	0.98	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM163	0.17	0.21	lasso	5	0.20	1.6e-22	5.6	-5.6	2.5e-08	-0.39	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Lung Adenocarcinoma	ZRANB3	0.02	0.02	lasso	11	0.03	5.4e-04	5.5	-5.2	2.2e-07	-0.40	0.13	0.81	FALSE
47	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DARS	0.02	0.02	lasso	2	0.02	3.9e-03	6.5	6.5	5.8e-11	0.57	0.02	0.92	FALSE
48	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZRANB3	0.05	0.04	blup	118	0.05	1.3e-06	5.2	-5.2	1.5e-07	-0.41	0.19	0.81	FALSE
49	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ZRANB3	0.27	0.07	enet	39	0.06	7.1e-05	3.1	-5.2	1.7e-07	-0.48	0.48	0.33	FALSE
50	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DARS	0.08	0.10	lasso	4	0.09	8.8e-05	6.6	6.6	4.2e-11	0.58	0.02	0.94	FALSE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	DARS	0.04	0.02	blup	40	0.01	2.1e-02	6.7	7.8	9.3e-15	0.59	0.02	0.94	FALSE
52	The Cancer Genome Atlas	Soft Tissue Sarcoma	DARS	0.04	0.04	blup	40	0.04	1.6e-03	6.5	7.2	5.9e-13	0.62	0.02	0.92	FALSE
53	The Cancer Genome Atlas	Soft Tissue Sarcoma	LCT	0.09	0.04	blup	36	0.05	4.9e-04	7.6	-7.6	3.0e-14	-0.61	0.00	0.90	TRUE
54	The Cancer Genome Atlas	Soft Tissue Sarcoma	MCM6	0.10	0.04	enet	5	0.04	1.5e-03	3.3	6.9	6.6e-12	0.62	0.01	0.82	FALSE
55	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ZRANB3	0.19	0.10	lasso	7	0.12	6.5e-05	5.4	-5.6	2.8e-08	-0.38	0.11	0.76	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	DARS	0.22	0.15	enet	13	0.19	4.1e-18	6.5	6.1	1.1e-09	0.42	0.03	0.97	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM163	0.14	0.14	lasso	8	0.18	2.4e-17	5.6	-5.2	1.9e-07	-0.35	0.00	1.00	FALSE
58	The Cancer Genome Atlas	Thyroid Carcinoma	ZRANB3	0.07	0.04	blup	118	0.06	3.3e-06	4.3	-5.6	2.7e-08	-0.43	0.13	0.86	FALSE