Best TWAS P=2.8e-08 · Best GWAS P=5.96e-08 conditioned to 0.00877
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Atrial Appendage | COPS7B | 0.22 | 0.01 | lasso | 6 | 0.01 | 1.3e-01 | 5.1 | 5.5 | 5.0e-08 | 0.90 | 0.03 | 0.44 | TRUE |
| 2 | GTEx | Prostate | B3GNT7 | 0.34 | 0.15 | lasso | 3 | 0.08 | 4.4e-03 | 5.4 | -5.4 | 7.9e-08 | 0.00 | 0.01 | 0.96 | TRUE |
| 3 | YFS | Blood | EIF4E2 | 0.06 | 0.04 | enet | 27 | 0.04 | 2.8e-13 | -5.2 | -5.2 | 2.2e-07 | -0.03 | 0.01 | 0.98 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DIS3L2 | 0.05 | 0.02 | enet | 10 | 0.02 | 3.8e-05 | 3.5 | 5.2 | 2.1e-07 | 0.14 | 0.08 | 0.03 | TRUE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EIF4E2 | 0.03 | 0.03 | enet | 8 | 0.04 | 4.4e-08 | -5.1 | 5.1 | 2.9e-07 | 0.05 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EIF4E2 | 0.03 | 0.01 | blup | 60 | 0.02 | 2.7e-03 | -4.4 | 5.4 | 7.1e-08 | 0.09 | 0.02 | 0.71 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | CHRNG | 0.04 | 0.00 | blup | 58 | 0.00 | 1.3e-01 | -3.6 | 5.5 | 2.8e-08 | 0.15 | 0.01 | 0.30 | TRUE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | EIF4E2 | 0.03 | 0.01 | blup | 63 | 0.02 | 4.7e-03 | -5.1 | 5.5 | 4.2e-08 | 0.10 | 0.01 | 0.86 | FALSE |