TWAS hub - CHRNG

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Lung Adenocarcinoma	0.0402	0.0244	9.2e-03	-0.001	0.003	0.000	NA	0.000	5.5e-01	1.3e-01	0.37000	NA	0.31000
2	TCGA	Lung Squamous Cell Carcinoma	0.0813	0.0321	2.9e-05	0.055	0.034	0.027	NA	0.039	7.0e-07	8.8e-05	0.00046	NA	0.00003

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Comparative height size at age 10	6.3	34.7	68.7	-8.3	-0.9
Hair/balding pattern: Pattern 2	6.0	7.7	8.1	2.7	2.8
Relative age of first facial hair	5.7	11.8	23.1	-4.8	-0.7
Height	5.4	103.7	193.2	-13.9	-3.8
Medication: Ibuprofen (e.g. Nurofen)	5.2	6.5	12.9	0.4	3.6
Standing height	5.2	51.6	94.3	-9.7	-3.0
Leg pain on walking	5.1	6.3	11.0	-3.3	-1.3
Arm fat-free mass (right)	4.5	23.1	42.9	-6.5	-1.8
Ulcerative Colitis	4.2	6.1	7.5	2.7	2.2
Arm predicted mass (right)	4.2	21.7	40.1	-6.3	-1.8
Pulse rate	4.1	6.9	10.0	-1.9	-3.2
Had menopause	3.6	4.5	8.3	-2.9	-0.8
Arm fat-free mass (left)	3.6	18.1	34.3	-5.9	-1.4
Sitting height	3.5	25.0	41.2	-6.4	-3.0
Relative age voice broke	3.4	5.2	9.4	-3.1	-1.0
Had major operations	3.3	3.9	4.8	-1.7	-2.2
Arm predicted mass (left)	3.3	16.9	32.6	-5.7	-1.1
Myopia	3.2	4.7	7.7	2.8	-1.3
Lung FVC	3.1	15.6	30.8	5.5	-0.7
Medication: Ibuprofen	3.1	3.7	6.5	1.0	2.5
Basal cell carcinoma (self-reported)	3.1	3.6	4.3	2.1	1.7
Forced expiratory volume in 1-second (FEV1), predicted	3.0	6.1	10.4	-3.2	-1.4
Tinnitus: Yes, but not now, but have in the past	2.7	2.9	3.9	2.0	1.4
Trunk fat-free mass	2.7	15.5	28.6	-5.3	-1.5
Trunk predicted mass	2.7	15.4	28.3	-5.3	-1.6
Diastolic blood pressure, automated reading	2.7	8.3	14.5	3.8	1.5
Heart disease (siblings)	2.7	3.3	6.0	2.4	-0.8
Whole body fat-free mass	2.6	14.8	26.8	-5.2	-1.6
Basal metabolic rate	2.6	14.2	25.8	-5.1	-1.6
Weight	2.5	12.2	23.4	-4.8	-1.0
Number of full brothers	2.5	3.2	6.2	2.5	-0.2
Whole body water mass	2.5	14.5	26.2	-5.1	-1.7
Qualifications: O levels/GCSEs or equivalent	2.4	3.8	6.3	-1.2	-2.5
Chest pain or discomfort	2.4	3.5	4.8	-2.2	-1.5
Schizophrenia vs Biploar Disorder	2.3	3.0	5.8	-0.5	2.4
Diabetes (father)	2.3	2.8	4.0	-1.3	2.0
Illnesses of mother	2.3	2.8	5.6	-2.4	-0.2
Commuting to job workplace: Walk	2.3	2.5	4.9	2.2	0.4
Trunk fat mass	2.2	9.4	18.4	-4.3	-0.6
Birth weight of first child	2.2	4.1	6.7	-1.2	-2.6
Age at first live birth	2.2	3.8	6.3	-2.5	-1.2
Medication: Allopurinol	2.2	3.0	4.2	-1.3	-2.0
Ulcerative Colitis (UC)	2.1	4.0	5.7	2.4	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	5.5	-2.3	0.2
Supplements: Glucosamine	2.1	2.7	5.1	0.6	2.3
Length of working week for main job	2.1	2.3	4.6	-0.1	-2.1
Medication: Seretide 50 evohaler	2.1	2.5	3.9	-1.0	-2.0
Average weekly fortified wine intake	2.0	2.4	3.6	-1.9	-1.1
Leg predicted mass (left)	2.0	10.4	17.7	-4.2	-1.7
Eye problems/disorders: None of the above	2.0	2.4	3.2	-1.8	-1.2
Illnesses of father: High blood pressure	2.0	2.4	4.8	-0.2	2.2
Commuting to job workplace: Cycle	2.0	2.4	3.3	-1.2	-1.8
Leg fat-free mass (left)	1.9	10.2	17.5	-4.2	-1.7
High blood pressure (mother)	1.9	2.6	5.1	2.2	-0.4
Mouth/teeth dental problems: Bleeding gums	1.9	2.5	3.3	-1.3	-1.8
Age at First Birth	1.8	2.6	4.7	-2.2	-0.7
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	5.9	-2.4	0.1
Age at last live birth	1.8	2.6	3.3	-1.8	-1.4
Smoking Status	1.7	4.0	5.7	2.4	-1.5
Maternal smoking around birth	1.7	2.5	4.6	2.1	0.6
Hip circumference	1.7	7.3	13.2	-3.6	-1.2
Whole body fat mass	1.7	6.9	13.7	-3.7	-0.4
Leg fat-free mass (right)	1.7	9.3	15.5	-3.9	-1.8
Loneliness, isolation	1.7	2.4	2.7	-1.6	1.4
Osteoporosis (self-reported)	1.7	2.2	4.2	-2.0	0.4
Leg predicted mass (right)	1.7	9.3	15.7	-4.0	-1.7
Health satisfaction	1.6	2.0	3.4	-1.8	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	6.4	2.5	0.6
Irritable Bowel Disease (IBD)	1.5	3.6	6.4	2.5	0.9
HbA1C	1.5	1.7	3.1	0.6	1.8
Frequency of depressed mood in last 2 weeks	1.5	2.1	4.1	-2.0	-0.0
Medication: Co-codamol	1.5	1.8	2.3	-1.1	-1.5
Prospective memory result	1.5	1.9	3.7	-1.9	-0.2
Pulse wave Arterial Stiffness index	1.5	1.7	3.4	-1.9	-0.2
Pulse wave reflection index	1.5	1.8	2.1	1.5	1.2
Supplements: Vitamin C	1.5	1.7	3.2	-1.8	0.5
Pain type(s) experienced in last month: Hip pain	1.5	1.9	3.0	-1.7	0.9
Hand grip strength (right)	1.4	3.8	6.2	-1.2	-2.5
Qualifications: None of the above	1.4	3.0	4.3	2.1	1.3
Pulse rate, automated reading	1.4	4.5	8.0	-2.8	-0.9
Smoking status: Previous	1.4	2.0	3.5	1.9	-0.8
Ever had hysterectomy (womb removed)	1.3	1.4	2.9	-1.7	0.1
Vitamin and mineral supplements	1.3	1.8	3.4	1.9	-0.4
Birth weight	1.3	2.9	4.6	-1.1	-2.1
Schizophrenia (2014)	1.2	2.7	4.8	-0.9	2.2
Trunk fat percentage	1.2	4.8	9.4	-3.1	-0.4
Happiness	1.2	1.5	2.1	-1.4	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	3.4	-1.8	-0.6
Medication: Paracetamol	1.2	1.8	3.2	1.8	0.7
Medication: Lisinopril	1.2	1.6	1.9	1.1	1.4
Intelligence (Savage-Jansen 2018)	1.1	3.5	3.7	-1.8	-1.9
Schizophrenia (2018)	1.1	2.4	2.8	-1.7	1.4
Medication for hormone replacement therapy	1.1	1.2	2.3	-0.2	1.5
Had other major operations	1.1	1.3	2.6	-0.3	1.6
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	2.6	-1.6	-0.3
Financial difficulties in last 2 years	1.1	1.5	2.3	-0.9	-1.5
Medication: Ramipril	1.1	1.4	2.5	1.6	-0.4
Father’s age at death	1.1	1.4	1.9	-1.4	-1.0
Leg fat mass (right)	1.1	4.2	8.5	-2.9	0.1
Mood swings	1.1	2.0	3.3	-1.8	-0.8
Blood Platelet Count	1.0	11.8	23.5	-4.8	-0.3
Emphysema/chronic bronchitis	1.0	1.1	1.8	0.6	-1.4
Medication for pain relief, constipation, heartburn	1.0	1.8	2.0	-1.2	-1.4
Medication: Blood pressure	1.0	1.7	3.2	1.8	0.4
Medication: Aspirin	1.0	1.4	2.5	-0.5	-1.6
Illnesses of father: Heart disease	1.0	1.4	2.8	0.1	-1.7
Irritability	1.0	1.6	1.6	-1.3	-1.3
Leg fat mass (left)	1.0	3.9	7.8	-2.8	-0.1
Depression (Nagel 2018)	0.9	1.3	2.6	-1.6	0.1
Qualifications: CSEs or equivalent	0.9	1.2	1.7	0.8	1.3
Medication: Atenolol	0.9	1.1	2.2	0.2	1.5
Past tobacco smoking	0.9	1.6	2.7	-1.6	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	2.2	-1.5	-0.7
Pain all over the body in last month	0.9	0.9	1.8	-0.1	1.4
Falls in the last year	0.9	1.2	2.3	0.1	1.5
Tense / ‘highly strung’	0.9	1.5	2.0	-1.4	1.0
Shortness of breath walking on level ground	0.9	1.0	1.9	-1.4	-0.4
Migraine (self-reported)	0.9	1.1	1.7	1.3	0.7
Back pain experienced in last month	0.9	1.3	2.6	-0.2	-1.6
Alcohol drinker status: Never	0.9	1.1	2.3	0.1	1.5
Bipolar Disorder or Schizophrenia	0.8	1.8	2.2	-1.5	1.2
Reaction Time	0.8	1.6	2.8	0.6	1.7
Ovarian Cancer	0.8	1.0	1.7	1.3	-0.6
Lung FEV1/FVC ratio	0.8	3.9	4.2	-2.1	1.9
Supplements: Zinc	0.8	0.9	1.8	1.3	-0.2
Stomach or abdominal pain in last month	0.8	1.0	1.7	-0.6	-1.3
Number of incorrect matches in round	0.8	1.4	2.1	1.4	0.8
Medication: Simvastatin	0.8	1.2	2.3	0.4	-1.5
Ever had bowel cancer screening	0.8	1.0	1.5	-0.7	-1.2
Eye problems/disorders: Cataract	0.8	0.9	1.7	1.3	-0.0
Medication: Aspirin	0.8	1.0	1.9	0.2	-1.4
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.8	-0.2	1.4
Alzheimer’s Disease (in father)	0.7	0.7	1.3	0.3	1.2
Blood White Count	0.7	5.3	10.6	-3.2	0.2
Waist Hip Ratio (WHR)	0.7	3.1	5.3	1.0	2.3
Sensitivity / hurt feelings	0.7	1.3	2.3	-1.5	0.5
Severe depression (siblings)	0.7	0.8	1.5	-1.2	0.4
Medication: Levothyroxine sodium	0.7	1.1	2.2	-0.2	1.5
Hair/balding pattern: Pattern 3	0.7	1.1	1.7	-1.3	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.7	1.4	-1.2	0.3
Lung cancer (father)	0.7	0.8	1.3	-1.1	0.6
Gout (self-reported)	0.7	1.0	1.9	-0.2	-1.4
Body fat percentage	0.7	2.9	5.8	-2.4	0.1
Exposure to tobacco smoke outside home	0.7	0.9	1.3	-1.1	-0.7
Angina (self-reported)	0.7	0.9	1.7	1.3	-0.2
Overall health rating	0.7	1.5	3.0	-1.7	-0.1
Illnesses of siblings: Diabetes	0.7	0.9	1.8	-0.2	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.2	-1.1	-0.6
Wears glasses or contact lenses	0.7	0.8	1.7	-0.1	-1.3
Mother’s age at death	0.7	0.9	1.4	-0.6	-1.2
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.2	-1.1	0.8
High cholesterol (Self-reported)	0.7	1.2	1.5	-1.2	-0.9
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.5	-1.2	-0.4
Pack years of smoking	0.7	1.0	1.6	-1.2	-0.6
Alzheimer’s Disease (in mother)	0.6	0.7	1.5	-0.0	-1.2
Alzheimer’s Disease (including proxy)	0.6	0.9	1.5	1.2	-0.5
Neuroticism (2016)	0.6	0.9	1.2	-1.1	-0.7
Rheumatoid Arthritis	0.6	0.8	1.4	1.2	0.6
Heel T-Score	0.6	4.8	9.5	3.1	-0.4
Systolic blood pressure, automated reading	0.6	1.8	2.4	1.1	1.6
Pack years adult smoking proportion	0.6	0.9	1.7	-1.3	-0.2
Age when periods started (menarche)	0.6	1.4	1.9	1.0	1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.4	1.5	0.4
Serious illness, injury or assault to yourself	0.6	0.8	1.6	0.1	-1.2
Waist circumference	0.6	2.4	4.3	-2.1	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	2.7	1.6	0.5
Diabetes (self-reported)	0.6	1.0	1.1	-1.1	-0.9
Exposure to tobacco smoke at home	0.6	0.7	1.3	0.3	1.1
Hair/balding pattern: Pattern 4	0.6	1.4	2.7	-0.4	-1.6
Loud music exposure frequency	0.6	0.7	0.7	0.8	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	0.7	0.9	-0.8
Medication: Omeprazole	0.6	0.7	1.0	0.6	1.0
Diabetes diagnosed by doctor	0.6	0.9	1.4	-1.2	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.2	1.1	0.4
Arm fat mass (left)	0.6	2.5	5.0	-2.2	-0.2
Eye problems/disorders: Glaucoma	0.6	0.7	1.4	0.0	1.2
Number of operations (self-reported)	0.6	0.9	1.2	-1.1	-0.8
Age started oral contraceptive pill	0.6	0.7	1.4	-1.2	0.2
Mean Putamen Volume	0.5	0.5	0.6	0.8	0.7
Fasting Glucose	0.5	0.6	0.9	0.5	1.0
LDL Cholesterol	0.5	0.7	1.5	1.2	0.1
Number of treatments/medications taken	0.5	0.9	1.5	1.2	0.5
Angina	0.5	0.7	1.1	1.0	-0.6
Time employed in main current job	0.5	0.6	0.7	-0.8	-0.7
Qualifications: A levels/AS levels or equivalent	0.5	1.2	1.3	-1.1	-1.1
Medication: Lansoprazole	0.5	0.6	1.2	-0.2	-1.1
Peak expiratory flow (PEF)	0.5	1.1	1.9	-0.6	-1.4
Blood clot in the leg (DVT)	0.5	0.6	1.1	0.4	1.0
Chronic bronchitis/emphysema (mother)	0.5	0.6	0.7	-0.8	-0.7
Leg fat percentage (right)	0.5	1.7	2.4	-1.5	1.0
Worry too long after embarrassment	0.5	0.9	1.6	-0.4	1.3
Wheeze or whistling in the chest in last year	0.5	1.0	1.8	-0.4	-1.3
Pulse wave peak to peak time	0.5	0.6	1.0	1.0	0.3
Neck or shoulder pain in last month	0.5	0.7	1.2	-0.6	1.1
Heart disease (mother)	0.5	0.6	0.8	0.9	-0.6
Commuting to job workplace: Car/motor vehicle	0.5	0.6	0.9	-0.5	0.9
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.1	0.3	1.0
Body Mass Index (BMI) (2010)	0.4	0.6	1.2	1.1	-0.2
Triglycerides	0.4	0.6	1.2	1.1	-0.2
Blood Red Count	0.4	4.2	7.0	2.7	1.2
Impedance of leg (right)	0.4	2.0	3.7	-1.9	0.5
Forced vital capacity (FVC)	0.4	1.4	2.8	0.2	-1.7
Heart attack	0.4	0.5	1.0	-0.2	1.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.1	1.0	0.2
Arm fat mass (right)	0.4	1.8	3.6	-1.9	0.3
Medication: Paracetamol	0.4	0.6	1.3	1.1	0.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.1	-1.1	0.5
High blood pressure (siblings)	0.4	0.6	1.1	-1.0	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.0	-0.2	-1.0
Knee pain experienced in last month	0.4	0.5	1.1	-0.1	1.0
Long-standing illness, disability or infirmity	0.4	0.6	0.9	1.0	0.4
Medication for cholesterol	0.4	0.5	1.1	-0.2	-1.0
Asthma (self-reported)	0.4	0.8	1.6	-0.3	-1.3
Ever taken oral contraceptive pill	0.4	0.4	0.8	-0.2	0.9
Cholesterol lowering medication	0.4	0.6	0.8	-0.6	-0.9
Depressed Affect (Nagel 2018)	0.3	0.7	1.3	-1.2	-0.1
Coronary Artery Disease (CAD)	0.3	0.3	0.3	0.6	0.6
Systolic Blood Pressure	0.3	1.7	3.4	0.3	1.8
Respiratory disease	0.3	0.6	0.8	-0.6	-0.9
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.0	-1.0	0.2
Chronotype (morning person)	0.3	0.8	1.5	0.3	1.2
Townsend deprivation index at recruitment	0.3	0.4	0.8	0.9	0.1
Taking other prescription medications	0.3	0.4	0.4	0.7	-0.6
Multivitamins +/- minerals	0.3	0.4	0.4	-0.6	-0.7
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.5	-0.7	0.5
Chronic bronchitis/emphysema (father)	0.3	0.4	0.5	0.5	-0.7
Impedance of leg (left)	0.3	1.6	3.0	-1.7	0.5
Number of live births	0.3	0.4	0.5	0.7	0.5
Noisy workplace	0.3	0.3	0.4	0.6	0.5
Mouth/teeth dental problems: Dentures	0.3	0.5	0.7	-0.5	-0.8
Asthma	0.3	0.6	1.1	-0.4	-1.1
Headache pain in last month	0.3	0.6	1.1	-1.1	-0.3
Glaucoma (self-reported)	0.3	0.4	0.8	0.9	-0.1
Forced vital capacity (FVC), Best measure	0.3	1.1	2.2	0.1	-1.5
Mean time to correctly identify matches	0.3	0.5	0.9	-0.5	0.9
Family relationship satisfaction	0.3	0.3	0.5	-0.7	-0.4
Medication: Atorvastatin	0.3	0.4	0.8	-0.1	0.9
Ever smoked	0.3	0.6	1.1	1.1	-0.2
Leg fat percentage (left)	0.3	1.1	1.6	-1.3	0.7
Fractured/broken bones in last 5 years	0.3	0.4	0.5	-0.7	-0.6
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.3	-1.2	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.5	0.7	0.5
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	-0.5	0.8
Neuroticism (Nagel 2018)	0.2	0.5	0.9	-1.0	-0.3
Lupus	0.2	0.4	0.7	-0.0	-0.8
Primary Biliary Cirrhosis	0.2	0.3	0.4	-0.5	-0.6
BMI	0.2	1.1	2.0	0.5	1.4
Hand grip strength (left)	0.2	0.4	0.7	-0.3	-0.8
Hearing difficulty/problems: Yes	0.2	0.4	0.7	-0.8	0.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.4	-0.6	-0.4
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.4	-0.5	0.6
Medication: Metformin	0.2	0.2	0.4	-0.7	-0.2
Diabetes (mother)	0.2	0.2	0.4	0.6	0.3
Current tobacco smoking	0.2	0.3	0.6	0.2	-0.8
Fed-up feelings	0.2	0.4	0.9	-0.9	0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.3	-0.4	0.6
High blood pressure	0.2	0.4	0.8	0.9	0.2
Hearing difficulty/problems with background noise	0.2	0.3	0.6	-0.8	-0.2
Mouth/teeth dental problems	0.2	0.3	0.4	0.6	0.3
Fluid intelligence score	0.2	0.5	1.0	1.0	0.2
Illnesses of siblings	0.2	0.3	0.6	-0.1	-0.8
Alcohol intake versus 10 years previously	0.2	0.4	0.6	0.8	-0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.1	0.1	-1.0
Medication: Cholesterol lowering	0.2	0.2	0.5	0.7	0.1
Breastfed as a baby	0.2	0.2	0.5	0.7	0.1
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	-0.7	-0.1
Medication: Amlodipine	0.2	0.3	0.3	0.5	-0.6
Number of children fathered	0.2	0.2	0.5	0.2	-0.7
Qualifications: College or University degree	0.2	0.6	1.0	-1.0	0.3
Suffer from ‘nerves’	0.2	0.4	0.7	0.8	0.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.2	0.5	0.4
Hypertension (Self-reported)	0.2	0.5	1.0	1.0	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.2	-0.4	-0.5
Smoking status: Current	0.2	0.4	0.7	0.2	-0.8
Financial situation satisfaction	0.2	0.2	0.3	0.5	0.3
Commuting to job workplace: Public transport	0.2	0.3	0.3	0.5	-0.6
Medication: Bendroflumethiazide	0.2	0.4	0.7	0.3	-0.8
Average weekly beer plus cider intake	0.2	0.3	0.5	0.7	-0.3
Ever depressed for a whole week	0.2	0.2	0.3	-0.6	-0.3
Alcohol drinker status: Previous	0.2	0.2	0.4	0.2	-0.6
Impedance of whole body	0.2	1.1	2.1	-1.4	-0.0
Crohns Disease (2017)	0.1	0.2	0.3	0.5	-0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.5	-0.7	-0.2
Breast Cancer	0.1	0.3	0.6	-0.2	-0.8
HDL Cholesterol	0.1	0.2	0.2	-0.4	-0.4
Cardiovascular Disease	0.1	0.3	0.5	0.4	0.7
Hypothyroidism (self reported)	0.1	0.1	0.2	-0.3	0.4
Neuroticism	0.1	0.2	0.3	-0.1	-0.6
Average weekly spirits intake	0.1	0.1	0.2	-0.1	-0.4
Body mass index (BMI)	0.1	0.3	0.4	-0.6	0.4
Alcohol usually taken with meals	0.1	0.2	0.2	-0.5	0.4
Allergy	0.1	0.2	0.2	0.4	0.4
Impedance of arm (right)	0.1	0.2	0.3	0.6	0.4
Arm fat percentage (right)	0.1	0.5	0.8	0.3	0.9
Worrier / anxious feelings	0.1	0.3	0.5	0.1	0.7
Depression (self-reported)	0.1	0.1	0.2	0.2	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.6	-0.5	-0.8
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	0.1	0.6
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.1	-0.2	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	-0.5	0.1
Alcohol intake frequency.	0.1	0.3	0.5	0.7	0.1
Arm fat percentage (left)	0.1	0.2	0.3	-0.3	0.6
Average weekly red wine intake	0.1	0.1	0.2	-0.4	0.2
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.2	0.4	0.4
Friendships satisfaction	0.1	0.1	0.2	0.0	-0.4
Qualifications: nursing, teaching	0.1	0.2	0.2	-0.4	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	-0.1	0.6
Mineral and other dietary supplements	0.1	0.2	0.3	0.3	-0.5
Breast cancer (self-reported)	0.1	0.1	0.2	-0.4	0.4
Osteoarthritis (self-reported)	0.1	0.1	0.2	-0.2	-0.5
Medication: Gliclazide	0.1	0.1	0.1	-0.2	-0.3
Illnesses of father: None of the above (group 1)	0.1	0.2	0.3	0.2	-0.6
Average weekly champagne plus white wine intake	0.1	0.2	0.4	-0.6	-0.1
Miserableness	0.1	0.2	0.4	-0.6	-0.2
Guilty feelings	0.1	0.2	0.3	-0.6	0.2
Hearing aid user	0.1	0.1	0.1	-0.4	-0.0
Medication: Blood pressure	0.1	0.2	0.4	0.2	0.6
Risk taking	0.1	0.1	0.2	0.5	-0.2
Unable to work because of sickness or disability	0.1	0.1	0.1	-0.3	0.3
Pain experienced in last month	0.1	0.1	0.3	0.2	0.5
Supplements: Calcium	0.1	0.1	0.2	-0.5	0.3
Bipolar Disorder (2018)	0.0	0.1	0.1	-0.3	0.2
Worry (Nagel 2018)	0.0	0.0	0.0	0.1	-0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.1	0.1	-0.2	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.1	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	-0.1	-0.0
Blood Eosinophil Count	0.0	0.4	0.6	-0.4	-0.7
Allergy or Eczema	0.0	0.1	0.1	0.1	0.3
Hair Pigment	0.0	1.3	2.7	-1.6	-0.0
Tanning	0.0	0.5	0.9	0.2	1.0
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	-0.2	0.2
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.1	-0.0	-0.3
Nervous feelings	0.0	0.0	0.1	0.3	-0.0
Neuroticism score	0.0	0.1	0.1	-0.3	0.3
Impedance of arm (left)	0.0	0.1	0.1	-0.3	-0.2
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.0	-0.1	0.1
Comparative body size at age 10	0.0	0.1	0.2	0.4	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.0	-0.1	0.2
Number of full sisters	0.0	0.0	0.1	-0.0	0.2
Number of self-reported non-cancer illnesses	0.0	0.1	0.1	-0.2	-0.2

Hub : Genes

CHRNG

Models

Trait associations