TWAS hub - COPS7B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.217	0.079	0.0054	0.010	NA	0.007	NA	0.008	0.110	NA	0.1500	NA	0.130
2	GTEx	Thyroid	0.085	0.037	0.0066	0.016	NA	0.029	NA	0.012	0.021	NA	0.0027	NA	0.036

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Height	9.2	177.7	292.4	-17.1	7.9
Comparative height size at age 10	7.3	40.1	74.3	-8.6	2.4
Standing height	6.8	67.8	106.1	-10.3	5.4
Leg pain on walking	5.8	7.2	8.7	-2.9	-2.4
Trunk fat-free mass	4.5	25.7	42.6	-6.5	3.0
Trunk predicted mass	4.5	25.7	41.7	-6.5	3.1
Arm predicted mass (right)	4.5	23.1	41.3	-6.4	2.2
Arm fat-free mass (right)	4.3	21.9	38.9	-6.2	2.2
Forced expiratory volume in 1-second (FEV1), predicted	4.2	8.6	13.9	-3.7	1.8
Worry (Nagel 2018)	4.0	8.5	13.0	-3.6	-2.0
Whole body fat-free mass	3.7	21.1	35.6	-6.0	2.6
Whole body water mass	3.7	21.3	35.5	-6.0	2.6
Arm fat-free mass (left)	3.6	18.5	33.8	-5.8	1.8
Arm predicted mass (left)	3.6	18.5	33.6	-5.8	1.8
Lung FVC	3.5	17.6	29.7	5.5	2.3
Tense / ‘highly strung’	3.3	5.5	10.1	-3.2	-1.0
Basal metabolic rate	3.3	18.5	32.9	-5.7	2.0
Sitting height	3.2	22.7	22.8	-4.7	4.8
Medication: Atenolol	3.1	3.8	6.7	-1.0	-2.6
Ever highly irritable/argumentative for 2 days	3.0	3.5	5.6	-1.2	-2.4
Loneliness, isolation	2.9	3.9	5.0	-2.2	-1.7
Number of full brothers	2.8	3.5	6.7	0.6	2.6
Ever used hormone-replacement therapy (HRT)	2.6	3.3	6.4	2.5	0.5
Ever had hysterectomy (womb removed)	2.6	2.9	4.2	2.1	1.3
Forced vital capacity (FVC)	2.6	10.1	19.4	-0.8	4.4
Leg fat-free mass (left)	2.5	13.1	21.6	-4.7	2.1
Leg predicted mass (left)	2.5	13.1	21.3	-4.6	2.2
Leg fat-free mass (right)	2.5	13.1	22.4	-4.7	2.0
Leg predicted mass (right)	2.5	13.1	22.1	-4.7	2.0
Eye problems/disorders: Diabetes related eye disease	2.4	2.7	3.4	-1.4	-1.9
Birth weight of first child	2.4	4.3	5.0	-1.9	2.2
Forced vital capacity (FVC), Best measure	2.4	8.8	17.1	-0.6	4.1
Schizophrenia (2018)	2.3	4.8	9.4	-3.1	-0.4
Nervous feelings	2.3	4.4	6.4	-2.5	-1.5
Number of children fathered	2.3	2.6	5.2	0.1	2.3
Suffer from ‘nerves’	2.3	3.7	6.2	-1.1	-2.5
Bipolar Disorder or Schizophrenia	2.2	5.3	10.5	-3.2	-0.3
Severe depression (siblings)	2.1	2.4	4.5	-2.1	0.5
Fractured/broken bones in last 5 years	2.1	2.7	4.8	0.8	2.2
Primary Biliary Cirrhosis	2.0	2.9	3.8	-1.9	-1.4
Weight	2.0	10.0	19.9	-4.5	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	2.6	-1.4	1.6
Diastolic blood pressure, automated reading	2.0	6.1	6.9	2.3	2.6
Frequency of depressed mood in last 2 weeks	1.9	2.6	4.1	-2.0	-1.1
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	4.7	-2.2	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.8	3.6	-1.9	-1.4
Mouth/teeth dental problems: Loose teeth	1.9	2.2	3.8	0.8	1.9
Body Mass Index (BMI) (2010)	1.8	2.5	3.8	2.0	-1.1
Hand grip strength (left)	1.8	4.8	6.4	-2.5	1.8
Eye problems/disorders: None of the above	1.8	2.1	3.1	1.8	1.0
Family relationship satisfaction	1.8	2.3	4.5	2.1	0.2
Qualifications: nursing, teaching	1.8	2.7	5.1	-2.2	-0.7
Medication: Co-codamol	1.7	1.9	3.2	1.8	-0.8
Age when periods started (menarche)	1.7	4.0	6.9	1.0	-2.6
Forced expiratory volume in 1-second (FEV1)	1.7	5.9	11.1	-0.8	3.3
Health satisfaction	1.7	2.2	4.3	0.3	-2.1
Hearing aid user	1.7	1.9	3.8	-1.9	-0.1
Leg fat percentage (left)	1.7	6.1	12.0	-0.6	-3.5
Breast Cancer	1.6	4.0	7.1	2.7	-0.9
Hand grip strength (right)	1.6	4.3	4.8	-2.0	2.2
Medication: Ventolin 100micrograms inhaler	1.6	2.1	2.7	-1.2	-1.6
Supplements: Fish oil (including cod liver oil)	1.6	2.1	3.8	-2.0	0.6
Ever depressed for a whole week	1.6	2.0	3.5	-1.9	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	4.1	1.6	2.0
Pain experienced in last month	1.5	2.6	4.3	2.1	-0.9
Current tobacco smoking	1.4	2.3	4.6	-0.2	-2.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.5	8.8	-0.5	3.0
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	3.3	-0.6	1.8
Smoking status: Current	1.4	2.2	4.4	-0.3	-2.1
Neuroticism (Nagel 2018)	1.3	3.0	3.8	-1.9	-1.5
Waist circumference	1.3	4.7	5.2	-2.3	-2.0
Depression (self-reported)	1.3	1.5	2.9	-0.3	1.7
Length of working week for main job	1.3	1.4	1.7	1.1	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	2.3	-0.8	-1.5
Blood Eosinophil Count	1.2	9.3	18.6	-4.3	-0.3
Heel T-Score	1.2	9.5	19.0	4.4	-0.3
Trunk fat mass	1.2	5.3	8.9	-3.0	-1.3
Illnesses of mother	1.2	1.5	1.8	-1.3	-1.1
Exposure to tobacco smoke at home	1.2	1.3	2.5	-0.4	-1.6
Leg fat percentage (right)	1.2	4.5	8.8	-0.4	-3.0
Pulse wave peak to peak time	1.2	1.5	2.9	-1.7	0.2
Medication: Omeprazole	1.2	1.4	2.3	-1.5	0.8
Heart disease (mother)	1.2	1.4	1.7	1.3	1.1
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.3	-1.5	-0.8
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.9	-1.7	0.3
Mean Putamen Volume	1.1	1.3	2.6	-0.1	1.6
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	1.6	0.9	1.3
Illnesses of siblings	1.1	1.6	2.8	-1.7	-0.6
Neuroticism score	1.1	2.2	2.9	-1.2	-1.7
Worrier / anxious feelings	1.1	2.0	2.8	-1.7	-1.1
Medication: Lansoprazole	1.1	1.3	1.6	0.9	1.3
Knee pain experienced in last month	1.1	1.6	3.0	-1.7	-0.5
Illnesses of father: None of the above (group 1)	1.1	1.3	2.0	-1.4	0.8
Leg fat mass (left)	1.1	4.3	4.6	-2.0	-2.1
Diabetes (father)	1.0	1.2	1.6	0.9	-1.3
High blood pressure (mother)	1.0	1.5	2.9	1.7	-0.0
Had other major operations	1.0	1.2	2.4	-1.5	-0.3
Body fat percentage	1.0	4.0	7.2	-0.9	-2.7
Whole body fat mass	1.0	4.2	5.6	-2.4	-1.7
Smoking status: Previous	1.0	1.4	1.8	1.3	1.1
Osteoarthritis (self-reported)	1.0	1.4	2.1	-1.4	0.8
Ever taken oral contraceptive pill	1.0	1.1	1.9	1.4	0.6
Major Depression (MDD)	0.9	1.1	2.3	-1.5	0.1
HbA1C	0.9	1.0	1.8	-0.4	-1.3
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.0	-0.3	-1.4
Systolic blood pressure, automated reading	0.9	2.5	4.7	0.6	2.2
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.9	-1.7	-0.1
Mouth/teeth dental problems	0.9	1.4	1.4	1.2	-1.1
Falls in the last year	0.9	1.2	2.2	0.5	1.5
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	2.7	-0.8	-1.6
Leg fat mass (right)	0.9	3.5	3.5	-1.9	-1.9
Financial situation satisfaction	0.9	1.2	2.3	1.5	0.0
Medication: Omeprazole (e.g. Zanprol)	0.9	1.0	1.1	-1.0	1.0
Prostate Cancer	0.8	1.2	1.8	1.3	0.8
Medication for hormone replacement therapy	0.8	0.9	1.4	-1.2	0.6
Trunk fat percentage	0.8	3.1	4.7	-1.2	-2.2
Fed-up feelings	0.8	1.5	2.9	-0.4	-1.7
Medication: Levothyroxine sodium	0.8	1.3	1.7	-1.3	-1.0
Pain all over the body in last month	0.8	0.8	1.5	-1.2	0.4
Peak expiratory flow (PEF)	0.8	1.9	3.6	-0.5	1.9
Age at last live birth	0.8	1.2	2.4	0.1	1.6
Average weekly red wine intake	0.8	1.1	1.9	1.4	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.5	1.2	0.5
Commuting to job workplace: Walk	0.8	0.9	1.8	0.2	1.3
Medication: Gliclazide	0.8	0.9	1.2	0.8	-1.1
Medication: Lisinopril	0.8	1.1	1.8	0.6	-1.3
Myopia	0.8	1.1	2.1	-1.4	-0.4
Supplements: Calcium	0.8	0.9	1.8	0.1	1.3
Systolic Blood Pressure	0.7	3.7	6.0	1.2	2.4
Neuroticism	0.7	1.7	2.1	-1.2	-1.5
Average weekly spirits intake	0.7	0.9	1.3	-1.1	-0.7
Chronic bronchitis/emphysema (father)	0.7	0.9	1.3	0.7	1.1
Number of incorrect matches in round	0.7	1.1	2.1	0.3	1.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.3	-0.6	-1.2
Arm fat percentage (right)	0.7	2.6	4.7	0.7	-2.2
Hip circumference	0.7	2.8	3.9	-2.0	-1.3
Pulse rate	0.7	1.1	2.2	1.5	-0.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.1	-0.5	1.4
Medication: Amlodipine	0.7	1.0	1.1	0.9	-1.0
Mineral and other dietary supplements	0.7	1.0	1.2	1.1	-0.8
Wears glasses or contact lenses	0.7	0.8	1.5	1.2	0.0
Medication: Paracetamol	0.7	1.1	2.0	-1.4	0.5
Risk taking	0.7	1.0	2.0	-0.3	-1.4
Alcohol drinker status: Previous	0.7	0.8	1.5	-0.5	1.2
Bipolar Disorder (2018)	0.6	0.9	1.8	-1.4	-0.1
Reaction Time	0.6	1.1	1.5	-0.9	-1.2
LDL Cholesterol	0.6	1.0	2.0	-0.3	-1.4
Schizophrenia (2014)	0.6	1.3	2.6	-1.6	-0.1
Smoking Status	0.6	1.4	2.2	0.8	-1.5
Vitamin and mineral supplements	0.6	0.8	1.4	1.2	-0.4
Body mass index (BMI)	0.6	2.7	5.3	0.2	-2.3
Hair/balding pattern: Pattern 2	0.6	0.7	1.4	-1.2	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	1.5	1.2	1.1
Headache pain in last month	0.6	1.0	1.9	-1.4	0.2
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.4	-1.2	0.2
Neck or shoulder pain in last month	0.6	0.9	1.5	-1.2	0.5
Arm fat percentage (left)	0.6	2.5	4.8	0.5	-2.2
Osteoporosis (self-reported)	0.6	0.7	1.1	-0.6	1.0
Fasting Glucose	0.5	0.6	1.0	0.5	-1.0
BMI	0.5	2.8	3.9	1.3	-2.0
Waist Hip Ratio (WHR)	0.5	2.1	3.2	-1.8	-1.0
Sensitivity / hurt feelings	0.5	0.8	1.6	-1.2	-0.3
Diabetes (mother)	0.5	0.6	1.2	-1.1	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.0	-0.7	-1.0
Medication: Paracetamol	0.5	0.8	1.4	-1.2	0.3
Medication: Ibuprofen	0.5	0.6	0.9	-0.9	-0.5
Mean time to correctly identify matches	0.5	0.9	1.5	-1.2	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.6	-1.3	0.4
Number of self-reported non-cancer illnesses	0.5	0.8	1.0	-0.8	-1.0
Guilty feelings	0.5	0.7	1.2	-0.5	-1.1
Commuting to job workplace: Public transport	0.5	0.6	0.6	0.7	0.8
Average weekly beer plus cider intake	0.5	0.8	1.5	-1.2	-0.2
Depressed Affect (Nagel 2018)	0.4	0.9	1.8	-0.2	-1.3
Alzheimer’s Disease (in mother)	0.4	0.5	1.0	0.2	-1.0
Alzheimer’s Disease (including proxy)	0.4	0.6	1.0	0.3	-1.0
Bipolar Disorder (2011)	0.4	0.4	0.6	0.8	-0.4
Coronary Artery Disease (CAD)	0.4	0.4	0.8	-0.9	0.3
Chronotype (morning person)	0.4	0.9	1.8	-0.1	1.3
Hearing difficulty/problems: Yes	0.4	0.7	0.7	-0.8	-0.8
Supplements: Zinc	0.4	0.4	0.8	0.9	-0.2
Serious illness, injury or assault to yourself	0.4	0.5	0.6	-0.6	-0.8
Multivitamins +/- minerals	0.4	0.5	0.9	-0.9	0.3
Financial difficulties in last 2 years	0.4	0.5	0.8	0.9	-0.5
Mouth/teeth dental problems: Dentures	0.4	0.6	1.0	-1.0	-0.4
Medication: Cholesterol lowering	0.4	0.6	0.7	0.8	-0.8
Lung cancer (father)	0.4	0.4	0.9	0.1	-0.9
Breastfed as a baby	0.4	0.5	0.7	-0.9	0.5
Loud music exposure frequency	0.4	0.4	0.6	0.8	-0.6
Birth weight	0.4	0.9	0.9	-0.9	-0.9
High blood pressure (siblings)	0.4	0.6	1.1	1.1	-0.1
Comparative body size at age 10	0.4	1.0	2.0	0.3	-1.4
Worry too long after embarrassment	0.4	0.7	1.4	1.2	-0.1
Shortness of breath walking on level ground	0.4	0.4	0.9	-0.2	-0.9
Migraine (self-reported)	0.4	0.5	0.9	0.2	1.0
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.8	-0.3	0.9
High cholesterol (Self-reported)	0.4	0.8	0.9	0.8	-0.9
Ever smoked	0.4	0.7	1.4	1.2	0.1
Number of operations (self-reported)	0.4	0.6	1.1	1.1	0.1
Age started oral contraceptive pill	0.4	0.5	1.0	1.0	-0.2
Commuting to job workplace: Cycle	0.4	0.5	1.0	-0.4	1.0
Cholesterol lowering medication	0.4	0.6	0.8	0.6	-0.9
Basal cell carcinoma (self-reported)	0.4	0.4	0.5	0.6	0.7
Pack years of smoking	0.4	0.6	1.2	-0.3	-1.1
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.7	0.5	-1.3
Ovarian Cancer	0.3	0.4	0.8	-0.2	0.9
Lupus	0.3	0.4	0.8	-0.2	0.9
Cardiovascular Disease	0.3	1.1	2.2	1.5	0.3
Type 2 Diabetes (T2D) (2018)	0.3	0.6	0.6	-0.8	-0.8
Pack years adult smoking proportion	0.3	0.5	1.0	-0.2	-1.0
Townsend deprivation index at recruitment	0.3	0.4	0.6	-0.8	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.5	-0.5	-0.7
Relative age voice broke	0.3	0.5	0.7	0.8	0.5
Qualifications: CSEs or equivalent	0.3	0.4	0.5	-0.7	0.6
Supplements: Glucosamine	0.3	0.3	0.7	0.1	0.8
Past tobacco smoking	0.3	0.6	1.1	-1.1	-0.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	-0.9	0.2
Medication: Ramipril	0.3	0.4	0.5	-0.5	0.7
Alcohol intake versus 10 years previously	0.3	0.4	0.7	-0.4	-0.8
Number of live births	0.3	0.5	0.7	0.5	0.8
Prospective memory result	0.3	0.4	0.7	0.1	-0.9
Pulse wave Arterial Stiffness index	0.3	0.3	0.6	0.7	0.3
Arm fat mass (right)	0.3	1.1	1.2	-1.1	-1.0
Pulse wave reflection index	0.3	0.4	0.5	0.5	-0.7
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.6	-0.7	-0.6
Exposure to tobacco smoke outside home	0.3	0.4	0.8	-0.9	-0.1
Medication for pain relief, constipation, heartburn	0.3	0.6	1.0	1.0	-0.4
Medication: Blood pressure	0.3	0.6	0.8	-0.6	-0.9
Chest pain or discomfort	0.3	0.5	0.8	-0.9	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.7	0.4	0.8
Hypertension (Self-reported)	0.3	0.9	1.0	1.0	1.0
Illnesses of father: Heart disease	0.3	0.4	0.8	0.9	0.2
Long-standing illness, disability or infirmity	0.3	0.4	0.5	-0.6	-0.7
Friendships satisfaction	0.3	0.4	0.8	0.9	0.3
Arm fat mass (left)	0.3	1.3	1.6	-1.3	-1.0
Miserableness	0.3	0.4	0.9	0.1	-0.9
Medication: Atorvastatin	0.3	0.4	0.6	0.8	-0.5
Illnesses of father: High blood pressure	0.3	0.4	0.4	0.6	-0.7
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.5	0.7	0.4
Heart disease (siblings)	0.3	0.3	0.6	0.8	0.2
Schizophrenia vs Biploar Disorder	0.2	0.3	0.5	-0.7	-0.3
Alzheimer’s Disease (in father)	0.2	0.2	0.3	-0.3	-0.6
HDL Cholesterol	0.2	0.3	0.5	-0.4	0.7
Neuroticism (2016)	0.2	0.3	0.6	-0.8	0.0
Triglycerides	0.2	0.3	0.5	0.7	-0.2
Blood Red Count	0.2	1.9	3.4	-0.6	1.8
Blood White Count	0.2	1.2	2.3	-1.5	0.1
Hypothyroidism (self reported)	0.2	0.4	0.4	-0.6	-0.7
Angina	0.2	0.2	0.4	-0.2	-0.7
Average weekly fortified wine intake	0.2	0.3	0.5	0.3	-0.7
Taking other prescription medications	0.2	0.3	0.5	-0.7	0.3
High blood pressure	0.2	0.7	1.1	1.0	0.5
Impedance of leg (left)	0.2	1.1	1.7	-0.7	-1.3
Heart attack	0.2	0.3	0.4	-0.6	-0.5
Allergy	0.2	0.4	0.8	0.0	0.9
Medication: Simvastatin	0.2	0.3	0.5	0.4	-0.7
Impedance of arm (right)	0.2	0.8	1.5	1.2	0.2
Time employed in main current job	0.2	0.3	0.5	0.7	0.1
Father’s age at death	0.2	0.3	0.6	0.8	-0.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.4	0.6	-0.4
Happiness	0.2	0.2	0.2	0.5	0.5
Noisy workplace	0.2	0.2	0.3	-0.4	0.5
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.9	-1.0	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	0.3	0.6
Age at first live birth	0.2	0.3	0.5	-0.7	-0.3
Qualifications: College or University degree	0.2	0.6	0.9	-1.0	0.4
Medication: Seretide 50 evohaler	0.2	0.3	0.4	-0.6	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.3	-0.6	-0.4
Alcohol intake frequency.	0.2	0.6	0.9	-0.9	0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.4	-0.4	-0.6
Medication: Aspirin	0.2	0.3	0.6	-0.8	0.2
Supplements: Vitamin C	0.2	0.3	0.5	-0.7	0.1
Back pain experienced in last month	0.2	0.3	0.5	-0.2	0.7
Medication: Aspirin	0.2	0.2	0.5	-0.7	0.0
Eye problems/disorders: Glaucoma	0.2	0.3	0.4	-0.6	-0.3
Medication: Blood pressure	0.2	0.4	0.5	0.7	0.5
Medication: Bendroflumethiazide	0.2	0.3	0.6	0.1	-0.8
Unable to work because of sickness or disability	0.2	0.3	0.4	-0.6	-0.5
Depression (Nagel 2018)	0.1	0.2	0.4	-0.7	0.0
Irritable Bowel Disease (IBD)	0.1	0.3	0.3	0.5	0.5
Ulcerative Colitis (UC)	0.1	0.2	0.4	0.7	0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.3	0.1	-0.5
Age at First Birth	0.1	0.1	0.1	-0.2	-0.4
Ulcerative Colitis	0.1	0.1	0.1	0.2	-0.4
Blood Platelet Count	0.1	0.7	1.3	0.1	-1.1
Respiratory disease	0.1	0.3	0.4	-0.4	-0.6
Lung FEV1/FVC ratio	0.1	0.4	0.6	-0.4	-0.8
Hair Pigment	0.1	3.4	6.6	-0.5	2.6
Tanning	0.1	0.7	1.2	0.3	1.1
Number of treatments/medications taken	0.1	0.2	0.4	-0.6	-0.1
Maternal smoking around birth	0.1	0.1	0.1	-0.2	-0.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	-0.2	0.5
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.4	-0.3
Alcohol usually taken with meals	0.1	0.1	0.1	0.3	-0.2
Hearing difficulty/problems with background noise	0.1	0.2	0.3	-0.5	0.5
Had menopause	0.1	0.2	0.2	-0.5	-0.3
Qualifications: None of the above	0.1	0.1	0.2	0.2	-0.5
Diabetes (self-reported)	0.1	0.2	0.3	-0.4	-0.5
Fluid intelligence score	0.1	0.3	0.6	0.8	0.1
Asthma	0.1	0.2	0.3	-0.5	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.1	-0.3	-0.1
Impedance of arm (left)	0.1	0.3	0.5	0.7	0.3
Hair/balding pattern: Pattern 4	0.1	0.1	0.1	0.4	0.3
Glaucoma (self-reported)	0.1	0.1	0.1	-0.3	0.3
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	-0.4	0.0
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.5	0.2
Angina (self-reported)	0.1	0.2	0.2	-0.2	-0.5
Medication: Allopurinol	0.1	0.2	0.3	-0.5	0.2
Overall health rating	0.1	0.2	0.3	-0.5	-0.4
Had major operations	0.1	0.1	0.2	0.0	-0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.2	-0.4	-0.4
Mood swings	0.1	0.2	0.3	0.0	-0.6
Ever had bowel cancer screening	0.1	0.1	0.2	0.0	-0.4
Diabetes diagnosed by doctor	0.1	0.1	0.2	-0.4	-0.2
Medication for cholesterol	0.1	0.2	0.2	0.4	-0.4
Breast cancer (self-reported)	0.1	0.2	0.2	0.3	-0.5
Asthma (self-reported)	0.1	0.3	0.4	-0.6	-0.4
Average weekly champagne plus white wine intake	0.1	0.2	0.3	0.5	-0.2
Mother’s age at death	0.1	0.1	0.1	-0.2	0.3
Alcohol drinker status: Never	0.1	0.1	0.2	-0.5	0.0
Irritability	0.1	0.2	0.3	-0.5	-0.4
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.5	-0.7	-0.0
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.1	-0.3	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.4	-0.1
Crohns Disease (2017)	0.0	0.1	0.2	0.2	0.4
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.1
Rheumatoid Arthritis	0.0	0.1	0.1	0.3	-0.0
Allergy or Eczema	0.0	0.1	0.2	-0.4	0.1
Relative age of first facial hair	0.0	0.1	0.1	0.1	-0.3
Medication: Metformin	0.0	0.0	0.1	-0.1	-0.3
Impedance of leg (right)	0.0	0.1	0.2	-0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.1	-0.0	-0.3
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.1	0.2	-0.3
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	0.2	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.1	0.1	-0.1	0.3
Blood clot in the leg (DVT)	0.0	0.0	0.0	0.1	-0.2
Gout (self-reported)	0.0	0.1	0.1	-0.4	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.0	-0.1	-0.0
Pulse rate, automated reading	0.0	0.0	0.1	-0.2	-0.3
Number of full sisters	0.0	0.0	0.0	0.0	0.2
Illnesses of siblings: Diabetes	0.0	0.0	0.1	0.0	-0.3
Eye problems/disorders: Cataract	0.0	0.0	0.0	0.1	-0.2
Impedance of whole body	0.0	0.0	0.0	0.1	-0.2

Hub : Genes

COPS7B

Models

Trait associations