Best TWAS P=1.66e-23 · Best GWAS P=3.55e-22 conditioned to 0.41
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | BOK | 0.20 | 0.12 | lasso | 4 | 0.12 | 1.4e-06 | -9.7 | -8.8 | 1.1e-18 | 0.97 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Brain Frontal Cortex BA9 | SEPT2 | 0.30 | -0.01 | enet | 32 | 0.02 | 1.1e-01 | 2.1 | 5.5 | 3.8e-08 | -0.13 | 0.07 | 0.05 | FALSE |
| 3 | GTEx | Heart Atrial Appendage | BOK | 0.15 | 0.01 | enet | 18 | 0.08 | 2.1e-04 | -9.7 | -7.5 | 6.4e-14 | 0.60 | 0.01 | 0.93 | FALSE |
| 4 | GTEx | Liver | AC114730.8 | 0.23 | -0.01 | enet | 27 | 0.03 | 6.5e-02 | -9.7 | 5.3 | 1.2e-07 | -0.51 | 0.01 | 0.79 | FALSE |
| 5 | GTEx | Lung | MTERFD2 | 0.14 | 0.01 | enet | 44 | 0.02 | 6.4e-03 | 3.3 | -5.2 | 1.8e-07 | 0.14 | 0.07 | 0.19 | FALSE |
| 6 | METSIM | Adipose | BOK | 0.06 | 0.03 | lasso | 6 | 0.03 | 7.8e-06 | -9.7 | -10.0 | 1.7e-23 | 0.95 | 0.00 | 1.00 | TRUE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C2orf54 | 0.09 | 0.10 | lasso | 3 | 0.10 | 3.1e-19 | -7.2 | 7.3 | 3.1e-13 | -0.07 | 0.09 | 0.91 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | C2orf54 | 0.08 | 0.03 | lasso | 1 | 0.02 | 2.1e-02 | -7.2 | 7.2 | 6.0e-13 | -0.07 | 0.03 | 0.83 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C2orf54 | 0.18 | 0.23 | lasso | 4 | 0.22 | 1.4e-24 | -7.2 | 7.2 | 5.8e-13 | -0.07 | 0.10 | 0.90 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C2orf54 | 0.33 | 0.27 | lasso | 2 | 0.27 | 1.4e-15 | -7.2 | 7.3 | 2.0e-13 | -0.06 | 0.10 | 0.90 | TRUE |
| 11 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | C2orf54 | 0.29 | 0.31 | enet | 6 | 0.32 | 1.5e-15 | -7.0 | 7.3 | 2.5e-13 | -0.07 | 0.17 | 0.83 | FALSE |
| 12 | The Cancer Genome Atlas | Lung Adenocarcinoma | C2orf54 | 0.15 | 0.11 | blup | 53 | 0.12 | 1.7e-13 | -7.2 | 6.2 | 5.5e-10 | -0.09 | 0.13 | 0.87 | FALSE |
| 13 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | BOK | 0.19 | -0.01 | lasso | 4 | 0.01 | 1.2e-01 | -9.7 | -7.6 | 2.9e-14 | 0.86 | 0.00 | 0.77 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | BOK | 0.07 | 0.04 | lasso | 5 | 0.03 | 1.8e-04 | 6.9 | -7.6 | 2.9e-14 | 0.76 | 0.01 | 0.97 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C2orf54 | 0.41 | 0.37 | lasso | 2 | 0.40 | 1.1e-44 | -7.2 | 7.2 | 6.4e-13 | -0.07 | 0.12 | 0.88 | FALSE |
| 16 | The Cancer Genome Atlas | Stomach Adenocarcinoma | C2orf54 | 0.16 | 0.05 | enet | 15 | 0.03 | 2.1e-03 | -7.1 | 6.9 | 4.6e-12 | -0.07 | 0.01 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | C2orf54 | 0.49 | 0.25 | enet | 19 | 0.28 | 1.7e-27 | -7.2 | 5.3 | 9.8e-08 | -0.06 | 0.09 | 0.91 | FALSE |