Best TWAS P=3.36e-09 · Best GWAS P=1.26e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | NOA1 | 0.15 | 0.15 | lasso | 4 | 0.13 | 1.6e-10 | 5.7 | -5.9 | 3.4e-09 | -0.99 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Artery Aorta | NOA1 | 0.17 | 0.06 | lasso | 4 | 0.06 | 3.5e-04 | 4.5 | -5.4 | 7.7e-08 | -0.53 | 0.04 | 0.92 | FALSE |
| 3 | GTEx | Muscle Skeletal | NOA1 | 0.12 | 0.07 | lasso | 4 | 0.07 | 1.7e-07 | 5.7 | -5.6 | 2.8e-08 | -0.97 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Testis | REST | 0.15 | 0.08 | enet | 12 | 0.04 | 7.4e-03 | -3.9 | -5.4 | 5.7e-08 | -0.66 | 0.05 | 0.93 | FALSE |
| 5 | GTEx | Thyroid | NOA1 | 0.08 | 0.03 | lasso | 5 | 0.03 | 1.7e-03 | -5.4 | -5.8 | 6.4e-09 | -0.70 | 0.02 | 0.96 | FALSE |
| 6 | METSIM | Adipose | NOA1 | 0.10 | 0.06 | blup | 546 | 0.07 | 4.0e-11 | 4.5 | -5.3 | 1.4e-07 | -0.72 | 0.01 | 0.99 | FALSE |
| 7 | YFS | Blood | IGFBP7 | 0.07 | 0.02 | enet | 13 | 0.07 | 4.4e-23 | -3.5 | -5.6 | 2.4e-08 | -0.37 | 0.77 | 0.20 | TRUE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C4orf14 | 0.03 | 0.04 | lasso | 3 | 0.04 | 1.9e-05 | -5.5 | -5.9 | 4.4e-09 | -0.54 | 0.01 | 0.96 | FALSE |
| 9 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C4orf14 | 0.13 | 0.11 | lasso | 2 | 0.10 | 6.2e-05 | -4.5 | -5.2 | 2.3e-07 | -0.52 | 0.05 | 0.62 | FALSE |