Hub : Genes

IGFBP7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.3790 0.0440 0.0e+00 0.341 0.266 0.391 0.384 0.387 5.9e-43 2.3e-32 1.2e-50 1.7e-49 5.3e-50
2 GTEx Brain Caudate basal ganglia 0.3150 0.1060 4.7e-03 0.015 NA 0.004 NA 0.005 1.2e-01 NA 2.4e-01 NA 2.3e-01
3 GTEx Cells Transformed fibroblasts 0.1840 0.0600 9.9e-04 0.023 NA 0.009 NA 0.018 7.2e-03 NA 6.3e-02 NA 1.6e-02
4 ROSMAP Brain Pre-frontal Cortex 0.2130 0.0360 1.7e-16 0.228 0.181 0.249 0.249 0.254 7.0e-29 1.0e-22 1.1e-31 8.5e-32 2.1e-32
5 YFS Blood 0.0697 0.0149 6.0e-13 0.019 0.051 0.074 0.066 0.074 4.5e-07 2.1e-16 4.4e-23 1.4e-20 4.7e-23

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.6 0.9 1.9 -1.0 -0.7 1.4 -0.9 -0.1
Bipolar Disorder or Schizophrenia 0.4 1.1 3.1 -1.0 -0.4 1.8 -1.0 -0.2
Depressed Affect (Nagel 2018) 0.1 0.2 0.4 -0.2 0.7 -0.2 -0.2 -0.6
Depression (Nagel 2018) 0.4 0.6 1.7 -0.2 1.1 -0.2 -0.3 -1.3
Intelligence (Savage-Jansen 2018) 1.7 5.3 14.9 -1.8 -3.9 -0.2 -1.9 -2.2
Neuroticism (Nagel 2018) 0.1 0.2 0.4 -0.5 0.6 0.2 -0.7 -0.3
Schizophrenia (2018) 0.1 0.3 0.8 -0.4 0.0 0.9 -0.5 -0.2
Schizophrenia vs Biploar Disorder 0.4 0.5 1.7 0.6 0.4 0.4 0.6 -1.3
Worry (Nagel 2018) 0.2 0.4 1.4 0.2 1.2 -0.3 0.3 -0.4
Alzheimer’s Disease (in mother) 1.6 1.9 6.8 -0.7 0.1 1.3 -0.7 -2.6
Alzheimer’s Disease (in father) 0.8 0.8 1.2 0.9 0.9 -1.0 1.1 -0.5
Alzheimer’s Disease (including proxy) 0.8 1.1 3.8 -0.3 0.8 1.1 -0.1 -2.0
Crohns Disease (2017) 0.5 1.2 2.2 0.5 -1.3 -1.5 0.6 -1.1
Irritable Bowel Disease (IBD) 0.7 1.6 5.8 -1.0 -2.4 -0.2 -1.1 -0.1
Ulcerative Colitis (UC) 1.0 1.8 3.9 -1.4 -2.0 0.8 -1.5 0.6
Major Depression (MDD) 0.5 0.6 1.6 -1.2 -0.2 -0.5 -1.1 -0.1
Reaction Time 0.9 1.7 7.3 -0.6 0.2 0.7 -0.6 2.7
Verbal and Numeric Reasoning (VNR) 1.4 3.3 10.0 -1.8 -3.2 -0.0 -1.7 -0.8
Breast Cancer 3.0 7.1 13.2 2.4 3.1 0.8 2.5 -3.6
Ovarian Cancer 0.9 1.1 4.0 -0.2 -2.0 -1.2 -0.3 -0.5
Prostate Cancer 0.7 0.9 2.0 -1.3 0.6 -0.1 -1.4 0.9
Age at First Birth 0.1 0.1 0.3 0.2 0.2 0.5 0.2 -0.1
Bipolar Disorder (2011) 0.4 0.4 0.6 -0.7 0.7 0.8 -0.6 0.4
Body Mass Index (BMI) (2010) 0.3 0.5 1.0 -1.0 -0.3 -0.0 -1.0 0.6
Coronary Artery Disease (CAD) 1.0 1.2 2.8 -1.6 -0.6 0.7 -1.7 -0.3
Crohns Disease (2012) 0.9 1.4 3.0 0.7 -1.6 -1.7 0.8 -0.5
Mean Putamen Volume 2.4 2.8 4.3 -2.0 -0.8 1.9 -2.1 1.0
Fasting Glucose 0.3 0.4 1.8 0.2 0.0 0.4 0.2 -1.3
HbA1C 1.7 1.8 3.5 1.8 1.5 -0.3 1.9 0.0
HDL Cholesterol 0.9 1.6 5.8 1.1 2.4 0.1 0.9 -0.0
LDL Cholesterol 0.5 0.8 1.6 -0.9 -0.1 0.9 -1.3 0.7
Lupus 0.6 1.0 1.4 1.1 0.9 0.5 1.0 1.2
Neuroticism (2016) 0.3 0.4 0.9 -0.8 0.1 0.9 -0.8 -0.2
Primary Biliary Cirrhosis 0.9 1.3 3.9 -1.0 -0.8 -0.4 -0.7 -2.0
Rheumatoid Arthritis 0.2 0.2 0.5 -0.7 0.1 0.4 -0.6 -0.3
Schizophrenia (2014) 0.2 0.5 1.6 -0.3 -0.7 1.3 -0.6 0.1
Triglycerides 0.0 0.0 0.2 -0.2 -0.4 -0.1 -0.2 -0.0
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.8 -0.3 0.9 -0.6 -0.2 0.3
Ulcerative Colitis 2.3 3.3 5.8 -2.3 -1.9 1.3 -2.4 0.2
Blood Eosinophil Count 0.5 3.8 15.7 1.0 0.4 -0.7 1.2 4.0
Blood Platelet Count 0.8 9.5 18.1 2.5 2.7 -4.3 2.7 2.9
Blood Red Count 0.6 5.7 8.8 -1.9 -3.0 2.6 -2.5 1.7
Blood White Count 0.5 3.7 14.8 1.0 0.7 -1.2 0.9 3.9
Heel T-Score 0.6 4.6 10.8 2.1 1.8 -0.7 2.0 3.3
BMI 0.2 1.1 1.6 -0.9 1.0 0.9 -1.1 1.3
Height 0.3 5.8 10.1 -2.1 -3.2 2.1 -2.5 -1.9
Waist Hip Ratio (WHR) 0.2 0.8 1.2 -0.8 -1.1 1.0 -0.8 -0.5
Systolic Blood Pressure 0.0 0.2 0.7 -0.0 -0.8 -0.3 -0.0 -0.3
Smoking Status 1.4 3.2 5.1 -2.3 -1.5 0.4 -2.0 -2.2
Allergy or Eczema 0.2 0.6 1.6 0.1 -0.5 -1.0 0.2 1.3
Cardiovascular Disease 0.1 0.5 1.4 0.6 -1.2 -0.6 0.2 0.3
Hypothyroidism (self reported) 0.1 0.2 0.5 -0.7 -0.0 0.3 -0.7 -0.3
Respiratory disease 1.0 2.1 6.7 0.6 -0.8 -1.7 0.5 2.6
Type 2 Diabetes (T2D) (2018) 0.5 1.0 2.9 -0.4 0.8 1.1 -0.3 -1.7
Lung FEV1/FVC ratio 0.3 1.4 2.4 -1.3 0.8 1.5 -1.0 -1.2
Lung FVC 3.4 17.2 31.1 4.2 3.2 -2.8 4.3 -5.6
Neuroticism 0.5 1.2 2.5 0.5 1.4 -0.9 0.6 -1.6
Chronotype (morning person) 0.1 0.3 0.6 0.3 0.8 -0.7 0.3 -0.2
Hair Pigment 0.1 1.8 8.0 0.1 0.6 -0.5 0.4 -2.8
Tanning 0.0 0.5 1.0 0.4 0.8 -1.0 0.3 -0.7
Hand grip strength (left) 0.6 1.6 6.2 -0.9 0.1 -0.8 -0.6 -2.5
Number of treatments/medications taken 0.2 0.4 1.4 0.5 1.2 0.3 0.4 -0.3
Average weekly spirits intake 0.8 1.1 2.0 -0.7 -1.4 -1.0 -0.9 1.0
Sensitivity / hurt feelings 0.1 0.2 0.4 -0.1 -0.5 -0.3 -0.4 0.6
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.2 -0.4 -0.0 -0.1 -0.5 -0.3
Hearing difficulty/problems: Yes 1.6 2.4 6.4 0.9 1.2 -1.3 1.2 -2.5
Relative age of first facial hair 1.2 2.4 6.6 1.4 0.7 -2.6 1.7 0.6
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.5 -0.8 -0.7 0.9 -0.9 1.2
Ever used hormone-replacement therapy (HRT) 0.5 0.6 1.5 0.2 -0.4 -1.2 0.3 -1.1
Ever had hysterectomy (womb removed) 2.5 2.8 5.7 1.2 0.3 -2.3 1.2 -2.4
Systolic blood pressure, automated reading 0.1 0.4 0.7 -0.6 -0.9 0.5 -0.4 0.7
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 0.9 -0.9 0.1 0.9 -0.9 0.5
Angina 1.2 1.6 4.2 1.3 -0.2 -0.5 1.3 -2.1
Medication for hormone replacement therapy 0.5 0.5 1.4 0.4 0.0 -1.0 0.3 1.2
Vitamin and mineral supplements 0.0 0.0 0.1 0.1 -0.2 0.3 0.1 0.2
Supplements: Zinc 0.2 0.3 0.7 -0.3 -0.9 -0.5 -0.4 0.2
Medication: Co-codamol 3.0 3.4 4.8 -2.2 -1.2 2.0 -1.9 1.8
Medication: Metformin 0.6 0.8 1.5 -1.2 -0.3 1.0 -1.2 0.4
Diabetes (father) 0.4 0.4 0.7 -0.8 0.8 0.4 -0.7 0.6
Diabetes (mother) 0.4 0.6 0.7 0.7 0.8 0.8 0.8 -0.6
Severe depression (siblings) 0.6 0.7 2.6 -0.3 -0.9 1.6 -0.2 -0.3
Pack years adult smoking proportion 0.9 1.4 2.4 -1.3 -0.9 1.0 -1.5 1.2
Impedance of leg (right) 2.0 9.6 19.5 4.0 2.8 -1.8 4.4 -1.3
Leg fat-free mass (left) 1.0 5.5 12.7 -3.1 -1.7 1.6 -3.6 0.5
Trunk fat percentage 0.7 2.9 7.3 1.5 1.8 0.4 1.2 2.7
Hand grip strength (right) 0.8 2.1 8.7 -0.9 -0.1 -0.6 -0.6 -3.0
Townsend deprivation index at recruitment 0.1 0.1 0.3 -0.5 -0.1 -0.0 -0.4 0.4
Current tobacco smoking 1.3 2.1 4.3 -1.8 -2.1 0.9 -1.4 0.5
Average weekly fortified wine intake 0.3 0.4 0.8 0.5 0.8 0.3 0.4 -0.9
Maternal smoking around birth 0.5 0.7 1.0 0.9 1.0 -0.3 0.8 -0.9
Fed-up feelings 0.3 0.6 1.7 0.5 0.6 -1.3 0.3 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 2.9 -1.7 0.5 0.3 -1.7 -0.8
Relative age voice broke 1.4 2.1 8.5 0.7 -0.3 -2.9 1.1 0.0
Taking other prescription medications 1.6 2.4 3.3 1.8 1.6 0.6 1.8 -1.6
Age when periods started (menarche) 0.8 2.0 5.1 1.2 1.0 -2.3 1.3 -0.9
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 0.7 0.9 -0.7 -0.7 0.7 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 3.8 0.6 1.5 0.5 0.6 1.9
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 3.0 -1.7 -0.7 -0.1 -1.6 1.3
Qualifications: CSEs or equivalent 1.6 2.0 7.2 -0.7 -1.3 -0.3 -0.9 2.7
Serious illness, injury or assault to yourself 1.1 1.3 3.0 1.1 0.3 -1.7 1.0 -1.2
High blood pressure 0.4 1.1 3.2 0.9 -0.4 -1.8 0.9 -0.8
Hayfever, allergic rhinitis or eczema 0.5 1.0 3.5 0.2 -0.6 -1.0 0.4 1.9
Multivitamins +/- minerals 0.2 0.2 0.6 -0.3 0.8 0.3 -0.1 0.5
Stomach or abdominal pain in last month 1.2 1.5 2.6 -1.6 0.3 0.8 -1.5 -1.4
Supplements: Glucosamine 0.5 0.7 1.3 1.0 1.1 -0.4 1.0 -0.3
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.9 -0.1 1.0 -0.0 -0.1 0.3
Medication: Atenolol 0.1 0.1 0.2 -0.1 -0.1 0.0 -0.3 0.5
Medication: Levothyroxine sodium 0.5 0.9 1.3 -0.9 -0.9 0.7 -1.0 1.1
Sitting height 1.3 9.4 15.7 -3.5 -2.5 3.4 -4.0 0.7
Chronic bronchitis/emphysema (father) 0.4 0.4 1.1 -0.6 0.1 1.0 -0.5 0.7
High blood pressure (mother) 0.3 0.4 1.2 -0.6 -0.0 -1.1 -0.4 0.3
Body mass index (BMI) 0.3 1.2 2.6 -1.0 0.3 0.7 -1.3 1.6
Impedance of leg (left) 1.3 6.4 13.4 3.2 2.5 -1.2 3.7 -0.8
Leg predicted mass (left) 1.1 5.9 13.5 -3.2 -1.7 1.7 -3.7 0.6
Trunk fat mass 0.4 1.6 5.7 0.2 1.2 0.9 -0.1 2.4
Waist circumference 0.7 2.4 4.2 -1.6 -1.2 0.7 -1.8 2.1
Number of incorrect matches in round 0.5 0.9 2.2 -0.1 0.6 1.2 -0.5 1.5
Past tobacco smoking 2.9 5.3 13.3 2.4 1.5 0.4 2.2 3.6
Alcohol usually taken with meals 0.6 1.0 2.3 0.5 -0.6 -1.3 0.5 1.5
Nervous feelings 0.2 0.3 1.0 -0.3 1.0 -0.6 -0.0 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.6 -0.3 -0.8 0.0 -0.4 0.1
Hearing difficulty/problems with background noise 1.0 1.6 6.1 -0.0 1.1 -0.8 0.1 -2.5
Hair/balding pattern: Pattern 2 0.2 0.3 1.1 0.2 0.1 -1.1 -0.1 -0.3
Had menopause 0.9 1.1 2.2 1.3 -0.4 -1.5 1.1 -0.3
Had other major operations 1.7 2.0 4.0 1.0 -1.2 -2.0 0.9 -1.7
Forced vital capacity (FVC) 1.9 7.4 22.2 2.0 1.1 -2.2 2.1 -4.7
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.5 7.1 0.5 0.3 0.1 0.5 2.7
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 3.2 -0.2 0.4 0.6 -0.2 -1.8
Qualifications: None of the above 0.0 0.0 0.1 -0.0 -0.3 -0.1 -0.2 0.2
Financial difficulties in last 2 years 1.8 2.5 6.3 -2.5 -0.2 1.0 -2.2 0.1
Mouth/teeth dental problems 0.1 0.2 0.4 0.5 0.4 -0.0 0.7 -0.1
Heart attack 0.8 1.0 2.4 -0.7 -0.8 1.5 -0.7 -1.0
Allergy 0.9 2.0 6.4 -0.4 1.5 1.0 -0.4 -2.5
Pain all over the body in last month 0.5 0.5 1.6 -0.4 -0.7 0.0 -0.4 1.3
Diabetes (self-reported) 0.3 0.4 1.4 -0.5 0.6 1.2 -0.3 0.3
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.3 -0.3 -1.2 -0.4 -0.6 1.1
Medication: Ramipril 0.6 0.8 1.6 -0.1 -1.0 -1.2 0.2 -1.3
Medication: Simvastatin 0.4 0.6 1.3 0.9 0.3 -0.4 0.8 -1.1
Fluid intelligence score 1.1 2.2 4.7 -1.9 -2.2 0.0 -1.6 -0.6
Illnesses of siblings 0.6 0.8 1.4 -1.2 0.1 1.2 -1.0 0.4
Neuroticism score 0.3 0.6 2.3 0.4 1.5 -0.7 0.4 -0.2
Weight 0.6 2.8 6.2 -2.2 -0.6 1.2 -2.5 1.1
Impedance of arm (right) 1.4 6.7 13.5 3.7 2.5 -0.6 3.7 0.2
Arm fat percentage (right) 0.5 2.0 5.5 0.6 1.8 0.8 0.4 2.3
Trunk fat-free mass 1.5 8.5 17.7 -4.0 -2.4 1.6 -4.2 -0.7
Hip circumference 0.5 2.3 7.0 -1.3 -0.6 0.2 -1.6 2.6
Time employed in main current job 0.3 0.4 1.0 -0.3 0.7 0.5 -0.1 1.0
Alcohol intake versus 10 years previously 0.2 0.3 0.8 -0.4 0.9 -0.3 -0.4 0.1
Father’s age at death 1.8 2.4 7.9 -1.3 -0.6 0.0 -1.3 2.8
Worrier / anxious feelings 0.4 0.7 1.7 -0.8 -1.3 -0.3 -0.9 0.2
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.3 3.7 -1.8 -1.0 0.5 -1.9 1.8
Falls in the last year 0.9 1.2 2.3 0.8 0.9 -1.5 0.6 1.4
Hair/balding pattern: Pattern 3 0.5 0.8 2.5 0.4 -0.8 -1.6 0.5 -0.7
Number of live births 0.4 0.5 2.3 -0.3 0.3 -0.0 -0.2 -1.5
Forced expiratory volume in 1-second (FEV1) 2.0 6.9 23.7 1.6 1.6 -1.7 1.6 -4.9
Pulse rate 0.3 0.5 1.3 0.8 -0.1 -0.3 0.6 1.2
Happiness 0.2 0.2 0.7 -0.2 0.2 -0.6 -0.2 -0.9
Noisy workplace 0.6 0.8 2.3 -0.7 0.6 1.5 -0.7 0.4
Qualifications: A levels/AS levels or equivalent 0.8 1.8 3.5 -1.8 -0.7 1.3 -1.9 -0.2
Serious illness, injury or assault of a close relative in last 2 years 2.0 2.3 4.2 -2.0 -0.6 1.7 -2.0 -0.3
Mouth/teeth dental problems: Dentures 0.1 0.1 0.2 -0.4 0.5 0.3 -0.3 0.2
Asthma 0.7 1.3 3.1 0.1 -1.1 -1.5 0.1 1.8
Medication: Ibuprofen (e.g. Nurofen) 3.4 4.3 8.7 -2.4 -0.9 0.6 -2.5 2.9
Medication: Cholesterol lowering 0.2 0.3 0.6 0.3 0.4 0.7 0.4 -0.8
Depression (self-reported) 3.6 4.3 6.5 2.5 2.5 -0.7 2.3 -1.6
Medication: Lansoprazole 0.2 0.2 0.4 -0.4 0.2 0.4 -0.6 -0.4
Prospective memory result 0.4 0.5 1.4 -0.4 -0.3 1.2 -0.8 -0.3
Lung cancer (father) 1.2 1.4 2.3 -1.5 -0.6 1.0 -1.5 1.0
Illnesses of mother 0.4 0.5 1.0 0.9 0.1 -0.5 0.6 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.3 14.1 0.3 1.4 -0.2 0.2 -3.8
Pulse wave Arterial Stiffness index 0.4 0.5 1.2 0.6 0.7 -1.1 0.7 0.2
Impedance of arm (left) 1.2 5.7 12.0 3.5 2.1 -0.4 3.4 0.8
Arm fat mass (right) 0.2 0.9 2.8 -0.3 1.0 0.7 -0.6 1.7
Trunk predicted mass 1.5 8.6 18.1 -4.0 -2.4 1.6 -4.3 -0.6
Standing height 0.5 4.9 8.9 -2.7 -2.2 1.4 -3.0 -1.2
Length of working week for main job 1.5 1.6 3.1 -1.8 -1.2 0.0 -1.7 1.0
Exposure to tobacco smoke at home 0.3 0.3 0.8 0.2 0.9 0.3 0.3 -0.7
Breastfed as a baby 0.4 0.5 1.2 -0.2 -0.2 -1.1 -0.0 -1.1
Tense / ‘highly strung’ 0.3 0.5 1.1 0.1 1.1 1.0 0.0 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 2.4 0.3 1.0 -1.2 0.4 -1.6
Hair/balding pattern: Pattern 4 0.4 1.1 1.8 -1.3 -0.9 1.3 -1.1 0.1
Birth weight of first child 0.9 1.6 3.9 -1.1 -2.0 0.7 -1.2 1.0
Peak expiratory flow (PEF) 0.9 2.1 7.5 -1.2 -0.5 0.5 -1.1 -2.7
Pulse wave reflection index 0.3 0.3 0.8 -0.9 0.0 0.3 -0.7 0.5
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.7 -0.3 -0.8 -0.0 -0.3 0.4
Loud music exposure frequency 0.4 0.4 1.1 -0.6 1.0 0.2 -0.8 -0.1
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 4.4 -1.5 -2.1 0.4 -1.0 0.1
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.7 -0.6 -0.2 0.5 -0.8 0.7
Blood clot in the leg (DVT) 0.2 0.2 1.1 0.1 -0.1 -1.1 0.2 0.2
Medication: Paracetamol 2.2 3.6 11.8 -1.3 -0.4 1.4 -1.6 3.4
Headache pain in last month 0.2 0.4 0.7 -0.6 -0.4 0.4 -0.7 0.9
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.8 0.0 -0.4 -0.7 -0.0 0.9
Glaucoma (self-reported) 0.6 0.7 1.8 -0.2 0.7 1.3 -0.3 -1.1
Gout (self-reported) 0.7 1.0 4.0 0.1 0.5 0.7 0.3 -2.0
Hypothyroidism/myxoedema (self-reported) 0.6 1.3 2.3 -1.3 -1.0 0.7 -1.5 0.9
Medication: Amlodipine 0.1 0.2 0.6 -0.4 0.3 -0.2 -0.4 0.7
Medication: Ventolin 100micrograms inhaler 1.3 1.7 3.0 1.5 -0.6 -1.7 1.5 0.8
Birth weight 1.6 3.4 5.7 -2.3 -1.7 1.6 -2.4 0.9
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.2 1.0 0.7 -0.9 1.1 0.1
High blood pressure (siblings) 1.9 2.7 3.7 1.9 1.4 -1.6 1.8 -1.5
Forced vital capacity (FVC), Best measure 0.8 3.1 12.5 0.9 1.0 -0.7 0.8 -3.5
Body fat percentage 0.6 2.5 7.5 1.1 1.7 0.3 0.9 2.7
Leg fat percentage (right) 0.7 2.7 5.0 1.6 2.2 -0.6 1.5 1.8
Arm fat-free mass (right) 1.5 7.5 16.6 -3.8 -2.2 1.4 -4.1 -0.0
Exposure to tobacco smoke outside home 0.2 0.2 0.7 0.9 -0.2 0.1 0.5 0.1
Comparative body size at age 10 0.5 1.3 2.0 -1.4 -0.2 1.0 -1.3 1.4
Number of full brothers 0.3 0.4 1.1 -0.7 -1.0 -0.4 -0.5 0.1
Worry too long after embarrassment 0.2 0.4 0.7 -0.8 0.0 0.0 -0.8 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 1.1 1.5 4.7 0.6 1.4 -0.4 0.4 -2.2
Wheeze or whistling in the chest in last year 1.9 3.3 4.9 -2.0 -2.0 0.3 -1.8 2.2
Number of children fathered 0.8 0.9 1.9 1.4 -0.3 -0.9 1.3 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 1.4 -0.0 0.0 1.2 -0.2 0.3
Age at first live birth 0.3 0.6 2.5 -0.0 -0.6 1.6 -0.2 0.4
Pulse wave peak to peak time 0.6 0.7 1.3 -0.8 -0.9 1.1 -0.9 -0.0
Health satisfaction 1.5 1.9 3.1 1.4 1.8 -1.0 1.4 1.2
Shortness of breath walking on level ground 0.2 0.2 1.1 0.1 -0.1 0.1 -0.2 1.1
Qualifications: College or University degree 0.4 1.3 2.0 -1.3 -0.6 1.2 -1.4 -1.1
Eye problems/disorders: None of the above 1.5 1.8 4.3 -0.5 0.9 1.6 -1.0 2.1
Mouth/teeth dental problems: Loose teeth 0.6 0.8 2.6 0.2 -0.6 -0.9 0.1 1.6
Emphysema/chronic bronchitis 0.9 1.0 3.3 0.7 -0.4 -1.8 0.9 0.5
Medication for pain relief, constipation, heartburn 2.9 4.9 9.0 2.1 1.3 -2.0 2.4 -3.0
Neck or shoulder pain in last month 2.3 3.3 4.5 -1.8 -2.1 1.4 -1.9 1.8
Medication: Blood pressure 0.1 0.2 0.5 0.0 0.4 0.6 -0.1 -0.7
Angina (self-reported) 1.2 1.6 4.3 1.3 -0.1 -0.4 1.3 -2.1
Migraine (self-reported) 0.2 0.3 0.9 0.6 0.4 0.0 0.2 -0.9
Medication: Ibuprofen 4.2 5.0 12.2 -2.4 -0.2 1.0 -2.5 3.5
Medication: Allopurinol 0.7 1.0 3.1 0.2 1.1 0.3 0.5 -1.8
Medication: Omeprazole 0.3 0.3 0.6 0.4 0.8 0.6 0.5 -0.4
Medication: Seretide 50 evohaler 0.4 0.4 0.9 0.9 0.3 -0.4 0.9 0.4
Mean time to correctly identify matches 0.3 0.6 2.6 0.1 0.6 0.1 0.2 1.6
Heart disease (mother) 0.3 0.4 0.6 -0.8 -0.3 0.8 -0.5 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.1 1.0 0.4 -0.6 0.9 -0.1
Whole body fat mass 0.3 1.1 4.0 0.1 1.1 0.7 -0.2 2.0
Leg fat mass (right) 0.2 0.8 2.3 -0.0 1.3 0.3 -0.2 1.5
Arm predicted mass (right) 1.3 6.5 14.1 -3.5 -2.1 1.4 -3.8 -0.2
Pulse rate, automated reading 0.2 0.7 1.4 -0.5 -0.7 1.1 -0.4 1.2
Alcohol intake frequency. 0.5 1.1 4.5 0.3 0.6 0.7 -0.0 2.1
Comparative height size at age 10 0.6 3.3 4.6 -1.8 -1.6 2.1 -2.1 1.2
Number of full sisters 0.6 0.8 1.7 -0.8 1.1 1.3 -0.5 -0.3
Suffer from ‘nerves’ 0.9 1.4 2.9 0.9 1.1 -1.7 1.3 0.6
Overall health rating 0.8 1.8 6.9 -0.6 -0.8 -0.5 -0.8 2.6
Chest pain or discomfort 0.7 1.0 2.0 -1.4 -1.1 -0.6 -1.3 0.2
Had major operations 0.8 0.9 1.7 0.7 0.4 -1.0 1.0 -1.3
Age at last live birth 1.0 1.5 3.7 -0.9 -1.2 1.9 -1.0 0.7
Family relationship satisfaction 0.7 0.8 1.7 -1.1 0.0 1.3 -1.2 0.3
Leg pain on walking 2.6 3.3 6.0 2.4 1.5 -1.4 2.4 0.3
Qualifications: NVQ or HND or HNC or equivalent 2.2 2.6 6.4 1.7 2.5 -1.0 1.6 -0.3
Commuting to job workplace: Car/motor vehicle 0.3 0.4 1.0 0.2 -1.0 -0.1 0.5 -0.7
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.4 0.5 -0.7 0.1 0.4 0.3
Medication: Aspirin 0.3 0.4 0.7 -0.4 -0.8 0.8 -0.5 -0.6
Supplements: Vitamin C 1.1 1.3 2.9 0.5 -0.7 -1.6 0.5 -1.7
Knee pain experienced in last month 0.6 0.9 1.4 1.2 0.9 -0.4 1.1 0.9
Hypertension (Self-reported) 0.1 0.4 1.0 0.4 -0.6 -1.0 0.4 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.6 -0.5 -1.3 0.6 -0.3 -0.1
Illnesses of father: Heart disease 0.1 0.1 0.2 0.2 -0.4 0.1 -0.0 -0.5
Illnesses of siblings: Diabetes 0.6 0.7 1.6 -0.5 -0.4 1.0 -0.8 1.3
Smoking status: Previous 1.8 2.7 10.2 -1.1 -0.5 -0.7 -1.1 -3.2
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.4 -0.7 -1.2 0.4 -0.7 -0.6
Whole body fat-free mass 1.4 8.2 17.8 -3.9 -2.2 1.7 -4.2 -0.1
Leg fat-free mass (right) 1.6 8.5 18.6 -3.8 -2.2 2.0 -4.3 0.8
Arm fat percentage (left) 0.5 2.0 7.0 0.5 1.6 0.6 0.2 2.6
Average weekly red wine intake 0.2 0.4 1.1 0.0 0.6 -1.1 -0.0 -0.5
Handedness (chirality/laterality): Left-handed 0.7 0.9 2.1 -1.3 -0.7 0.2 -1.4 0.4
Mood swings 0.3 0.5 1.2 -1.0 0.1 0.1 -1.1 0.6
Loneliness, isolation 1.1 1.5 2.5 -1.6 -1.3 0.3 -1.4 1.1
Long-standing illness, disability or infirmity 1.1 1.7 2.5 1.4 0.4 -1.4 1.6 1.4
Ever had bowel cancer screening 1.0 1.2 1.9 1.2 0.2 -1.2 1.0 -1.4
Diabetes diagnosed by doctor 0.1 0.1 0.3 -0.5 0.3 0.5 -0.3 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 2.2 2.3 3.9 -1.8 -0.4 2.0 -1.9 0.6
Friendships satisfaction 1.4 1.8 3.7 0.7 1.9 -1.6 0.7 -1.3
Qualifications: nursing, teaching 0.7 1.1 2.0 -1.1 -1.4 0.4 -1.4 0.3
Commuting to job workplace: Walk 0.9 1.0 3.3 0.8 0.3 -1.8 0.8 -0.3
Eye problems/disorders: Cataract 2.7 3.1 6.8 0.8 -1.1 -2.6 1.2 -2.3
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 0.6 -0.2 -0.7 -0.8 -0.5 -0.7
Medication for cholesterol 0.2 0.3 0.7 0.8 0.3 0.3 0.6 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 2.2 -1.1 -0.4 0.7 -1.0 1.5
Back pain experienced in last month 0.3 0.4 1.6 -0.4 0.0 -1.3 -0.0 0.3
Mineral and other dietary supplements 1.4 1.8 4.0 -1.6 -2.0 0.4 -1.6 0.4
Breast cancer (self-reported) 0.1 0.1 0.4 0.0 -0.2 -0.7 0.2 -0.1
Asthma (self-reported) 0.6 1.2 2.7 0.2 -1.0 -1.7 0.2 1.4
Osteoporosis (self-reported) 0.7 0.9 1.3 1.2 1.1 0.1 1.0 -1.0
Osteoarthritis (self-reported) 1.7 2.2 3.0 1.6 1.6 -0.8 1.5 1.7
Medication: Aspirin 0.2 0.3 0.7 -0.3 -0.7 0.8 -0.4 -0.3
Medication: Gliclazide 0.4 0.5 1.7 -0.6 0.4 0.4 -0.4 1.3
Illnesses of father: None of the above (group 1) 0.1 0.2 0.3 -0.5 -0.2 0.4 -0.4 -0.5
Smoking status: Current 1.2 1.9 3.6 -1.8 -1.9 0.8 -1.4 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.6 5.6 11.6 2.1 3.4 -0.0 2.3 -2.6
Whole body water mass 1.4 8.0 17.6 -3.9 -2.2 1.7 -4.2 -0.1
Leg predicted mass (right) 1.7 8.8 19.2 -3.8 -2.3 2.1 -4.4 0.8
Arm fat mass (left) 0.2 0.9 2.8 -0.4 0.7 0.6 -0.7 1.7
Number of self-reported non-cancer illnesses 0.2 0.3 1.4 0.1 -1.2 0.2 0.0 -0.1
Average weekly champagne plus white wine intake 0.3 0.5 2.1 -0.0 0.0 -1.5 -0.1 0.5
Miserableness 1.5 2.7 5.2 1.8 2.3 -0.2 1.9 -1.1
Guilty feelings 0.4 0.6 1.5 -1.2 0.3 0.5 -1.2 -0.3
Wears glasses or contact lenses 0.4 0.4 0.8 -0.9 0.1 0.5 -0.9 0.5
Ever taken oral contraceptive pill 0.3 0.3 1.1 0.2 1.0 -0.3 0.3 -0.6
Hearing aid user 1.0 1.2 3.5 -1.0 0.7 1.9 -0.9 -0.2
Mother’s age at death 0.3 0.3 1.3 0.3 0.3 0.2 0.4 -1.2
Financial situation satisfaction 1.0 1.3 4.9 -0.8 2.2 0.6 -0.6 -0.4
Tinnitus: Yes, now most or all of the time 2.6 3.0 12.6 0.3 1.1 0.9 0.3 -3.6
Commuting to job workplace: Public transport 0.9 1.1 3.2 0.1 1.8 1.3 -0.2 0.6
Eye problems/disorders: Glaucoma 0.5 0.6 1.9 0.4 0.2 0.8 0.5 -1.4
Medication: Blood pressure 0.3 0.7 2.4 -0.1 -0.4 -1.5 0.0 -0.9
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.2 0.3 -0.1 -0.3 0.4 0.4
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.9 0.0 1.0 0.4 0.1 0.3
High cholesterol (Self-reported) 0.1 0.2 0.4 0.2 -0.5 -0.3 0.1 -0.7
Medication: Bendroflumethiazide 0.1 0.2 0.4 -0.4 -0.3 0.6 -0.5 0.4
Medication: Paracetamol 1.7 2.6 8.5 -1.1 0.2 1.2 -1.4 2.9
Medication: Lisinopril 0.5 0.7 2.7 0.3 1.6 0.0 0.4 -0.8
Medication: Atorvastatin 1.0 1.3 3.3 -0.7 -1.3 0.7 -0.6 1.8
Illnesses of father: High blood pressure 0.5 0.6 1.5 1.2 0.2 -0.2 0.8 0.8
Alcohol drinker status: Never 0.2 0.3 0.6 0.5 -0.8 -0.6 0.3 0.5
Ever smoked 4.1 7.2 12.2 -3.5 -2.4 0.1 -3.1 -2.9
Basal metabolic rate 1.1 6.0 13.6 -3.3 -1.6 1.6 -3.7 0.2
Leg fat percentage (left) 0.5 2.0 4.1 1.0 1.9 -0.4 1.0 2.0
Arm fat-free mass (left) 1.1 5.6 12.5 -3.3 -1.9 1.1 -3.5 -0.2
Number of operations (self-reported) 1.7 2.5 4.0 1.6 0.6 -2.0 1.6 -1.8
Average weekly beer plus cider intake 0.8 1.2 3.2 0.4 0.9 -0.9 0.8 -1.8
Irritability 0.1 0.1 0.2 -0.1 0.5 0.4 -0.3 0.2
Risk taking 0.1 0.2 0.5 0.0 0.4 -0.5 -0.1 -0.7
Ever had prostate specific antigen (PSA) test 0.6 0.6 1.9 -0.5 -1.4 0.5 -0.7 -0.3
Fractured/broken bones in last 5 years 1.2 1.5 6.3 -0.2 0.8 0.6 -0.2 -2.5
Age started oral contraceptive pill 0.3 0.4 1.0 0.9 -0.4 -0.5 1.0 -0.2
Diastolic blood pressure, automated reading 0.1 0.2 0.5 0.5 0.1 -0.7 0.6 -0.1
Ever depressed for a whole week 0.2 0.3 1.1 -0.0 0.2 0.3 -0.3 -1.1
Unable to work because of sickness or disability 0.1 0.1 0.2 -0.4 0.5 -0.2 -0.2 0.1
Commuting to job workplace: Cycle 0.7 0.9 1.6 -0.8 1.3 -0.7 -0.6 -1.2
Myopia 0.5 0.7 1.8 -0.5 -0.4 -0.6 -0.9 1.3
Vascular/heart problems diagnosed by doctor 0.5 1.2 2.7 -0.8 0.8 1.6 -0.8 1.2
Cholesterol lowering medication 0.4 0.6 1.7 -0.8 -1.3 0.3 -0.8 -0.2
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.0 0.8 1.0 0.5 0.8 -0.2
Pain experienced in last month 1.7 2.9 6.2 2.0 2.5 -0.2 1.6 -1.3
Supplements: Calcium 0.9 1.0 2.6 0.7 -0.9 -1.6 0.4 -0.9
Basal cell carcinoma (self-reported) 0.3 0.4 0.9 0.9 -0.2 0.5 0.7 -0.5
Heart attack/myocardial infarction (self-reported) 0.7 0.9 2.5 -0.5 -1.0 1.6 -0.5 -0.9
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.6 0.1 -0.2 -0.7 0.2 0.3
Heart disease (siblings) 0.5 0.6 1.4 0.9 -0.6 -1.2 0.6 -0.3
Alcohol drinker status: Previous 1.0 1.1 4.1 0.2 0.8 0.9 -0.1 2.0
Pack years of smoking 0.4 0.6 1.1 -0.9 -0.6 0.7 -1.0 0.7
Impedance of whole body 1.5 7.7 15.9 3.8 2.6 -1.0 4.0 0.1
Leg fat mass (left) 0.2 0.8 2.5 -0.3 1.1 0.4 -0.4 1.6
Arm predicted mass (left) 1.1 5.5 12.2 -3.3 -1.7 1.2 -3.5 -0.4