Hub : Genes

IGFBP7

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3790	0.0440	0.0e+00	0.341	0.266	0.391	0.384	0.387	5.9e-43	2.3e-32	1.2e-50	1.7e-49	5.3e-50
2	GTEx	Brain Caudate basal ganglia	0.3150	0.1060	4.7e-03	0.015	NA	0.004	NA	0.005	1.2e-01	NA	2.4e-01	NA	2.3e-01
3	GTEx	Cells Transformed fibroblasts	0.1840	0.0600	9.9e-04	0.023	NA	0.009	NA	0.018	7.2e-03	NA	6.3e-02	NA	1.6e-02
4	ROSMAP	Brain Pre-frontal Cortex	0.2130	0.0360	1.7e-16	0.228	0.181	0.249	0.249	0.254	7.0e-29	1.0e-22	1.1e-31	8.5e-32	2.1e-32
5	YFS	Blood	0.0697	0.0149	6.0e-13	0.019	0.051	0.074	0.066	0.074	4.5e-07	2.1e-16	4.4e-23	1.4e-20	4.7e-23

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.6	0.9	1.9	-1.0	-0.7	1.4	-0.9	-0.1
Bipolar Disorder or Schizophrenia	0.4	1.1	3.1	-1.0	-0.4	1.8	-1.0	-0.2
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	-0.2	0.7	-0.2	-0.2	-0.6
Depression (Nagel 2018)	0.4	0.6	1.7	-0.2	1.1	-0.2	-0.3	-1.3
Intelligence (Savage-Jansen 2018)	1.7	5.3	14.9	-1.8	-3.9	-0.2	-1.9	-2.2
Neuroticism (Nagel 2018)	0.1	0.2	0.4	-0.5	0.6	0.2	-0.7	-0.3
Schizophrenia (2018)	0.1	0.3	0.8	-0.4	0.0	0.9	-0.5	-0.2
Schizophrenia vs Biploar Disorder	0.4	0.5	1.7	0.6	0.4	0.4	0.6	-1.3
Worry (Nagel 2018)	0.2	0.4	1.4	0.2	1.2	-0.3	0.3	-0.4
Alzheimer’s Disease (in mother)	1.6	1.9	6.8	-0.7	0.1	1.3	-0.7	-2.6
Alzheimer’s Disease (in father)	0.8	0.8	1.2	0.9	0.9	-1.0	1.1	-0.5
Alzheimer’s Disease (including proxy)	0.8	1.1	3.8	-0.3	0.8	1.1	-0.1	-2.0
Crohns Disease (2017)	0.5	1.2	2.2	0.5	-1.3	-1.5	0.6	-1.1
Irritable Bowel Disease (IBD)	0.7	1.6	5.8	-1.0	-2.4	-0.2	-1.1	-0.1
Ulcerative Colitis (UC)	1.0	1.8	3.9	-1.4	-2.0	0.8	-1.5	0.6
Major Depression (MDD)	0.5	0.6	1.6	-1.2	-0.2	-0.5	-1.1	-0.1
Reaction Time	0.9	1.7	7.3	-0.6	0.2	0.7	-0.6	2.7
Verbal and Numeric Reasoning (VNR)	1.4	3.3	10.0	-1.8	-3.2	-0.0	-1.7	-0.8
Breast Cancer	3.0	7.1	13.2	2.4	3.1	0.8	2.5	-3.6
Ovarian Cancer	0.9	1.1	4.0	-0.2	-2.0	-1.2	-0.3	-0.5
Prostate Cancer	0.7	0.9	2.0	-1.3	0.6	-0.1	-1.4	0.9
Age at First Birth	0.1	0.1	0.3	0.2	0.2	0.5	0.2	-0.1
Bipolar Disorder (2011)	0.4	0.4	0.6	-0.7	0.7	0.8	-0.6	0.4
Body Mass Index (BMI) (2010)	0.3	0.5	1.0	-1.0	-0.3	-0.0	-1.0	0.6
Coronary Artery Disease (CAD)	1.0	1.2	2.8	-1.6	-0.6	0.7	-1.7	-0.3
Crohns Disease (2012)	0.9	1.4	3.0	0.7	-1.6	-1.7	0.8	-0.5
Mean Putamen Volume	2.4	2.8	4.3	-2.0	-0.8	1.9	-2.1	1.0
Fasting Glucose	0.3	0.4	1.8	0.2	0.0	0.4	0.2	-1.3
HbA1C	1.7	1.8	3.5	1.8	1.5	-0.3	1.9	0.0
HDL Cholesterol	0.9	1.6	5.8	1.1	2.4	0.1	0.9	-0.0
LDL Cholesterol	0.5	0.8	1.6	-0.9	-0.1	0.9	-1.3	0.7
Lupus	0.6	1.0	1.4	1.1	0.9	0.5	1.0	1.2
Neuroticism (2016)	0.3	0.4	0.9	-0.8	0.1	0.9	-0.8	-0.2
Primary Biliary Cirrhosis	0.9	1.3	3.9	-1.0	-0.8	-0.4	-0.7	-2.0
Rheumatoid Arthritis	0.2	0.2	0.5	-0.7	0.1	0.4	-0.6	-0.3
Schizophrenia (2014)	0.2	0.5	1.6	-0.3	-0.7	1.3	-0.6	0.1
Triglycerides	0.0	0.0	0.2	-0.2	-0.4	-0.1	-0.2	-0.0
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.8	-0.3	0.9	-0.6	-0.2	0.3
Ulcerative Colitis	2.3	3.3	5.8	-2.3	-1.9	1.3	-2.4	0.2
Blood Eosinophil Count	0.5	3.8	15.7	1.0	0.4	-0.7	1.2	4.0
Blood Platelet Count	0.8	9.5	18.1	2.5	2.7	-4.3	2.7	2.9
Blood Red Count	0.6	5.7	8.8	-1.9	-3.0	2.6	-2.5	1.7
Blood White Count	0.5	3.7	14.8	1.0	0.7	-1.2	0.9	3.9
Heel T-Score	0.6	4.6	10.8	2.1	1.8	-0.7	2.0	3.3
BMI	0.2	1.1	1.6	-0.9	1.0	0.9	-1.1	1.3
Height	0.3	5.8	10.1	-2.1	-3.2	2.1	-2.5	-1.9
Waist Hip Ratio (WHR)	0.2	0.8	1.2	-0.8	-1.1	1.0	-0.8	-0.5
Systolic Blood Pressure	0.0	0.2	0.7	-0.0	-0.8	-0.3	-0.0	-0.3
Smoking Status	1.4	3.2	5.1	-2.3	-1.5	0.4	-2.0	-2.2
Allergy or Eczema	0.2	0.6	1.6	0.1	-0.5	-1.0	0.2	1.3
Cardiovascular Disease	0.1	0.5	1.4	0.6	-1.2	-0.6	0.2	0.3
Hypothyroidism (self reported)	0.1	0.2	0.5	-0.7	-0.0	0.3	-0.7	-0.3
Respiratory disease	1.0	2.1	6.7	0.6	-0.8	-1.7	0.5	2.6
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.9	-0.4	0.8	1.1	-0.3	-1.7
Lung FEV1/FVC ratio	0.3	1.4	2.4	-1.3	0.8	1.5	-1.0	-1.2
Lung FVC	3.4	17.2	31.1	4.2	3.2	-2.8	4.3	-5.6
Neuroticism	0.5	1.2	2.5	0.5	1.4	-0.9	0.6	-1.6
Chronotype (morning person)	0.1	0.3	0.6	0.3	0.8	-0.7	0.3	-0.2
Hair Pigment	0.1	1.8	8.0	0.1	0.6	-0.5	0.4	-2.8
Tanning	0.0	0.5	1.0	0.4	0.8	-1.0	0.3	-0.7
Hand grip strength (left)	0.6	1.6	6.2	-0.9	0.1	-0.8	-0.6	-2.5
Number of treatments/medications taken	0.2	0.4	1.4	0.5	1.2	0.3	0.4	-0.3
Average weekly spirits intake	0.8	1.1	2.0	-0.7	-1.4	-1.0	-0.9	1.0
Sensitivity / hurt feelings	0.1	0.2	0.4	-0.1	-0.5	-0.3	-0.4	0.6
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.4	-0.0	-0.1	-0.5	-0.3
Hearing difficulty/problems: Yes	1.6	2.4	6.4	0.9	1.2	-1.3	1.2	-2.5
Relative age of first facial hair	1.2	2.4	6.6	1.4	0.7	-2.6	1.7	0.6
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.5	-0.8	-0.7	0.9	-0.9	1.2
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.5	0.2	-0.4	-1.2	0.3	-1.1
Ever had hysterectomy (womb removed)	2.5	2.8	5.7	1.2	0.3	-2.3	1.2	-2.4
Systolic blood pressure, automated reading	0.1	0.4	0.7	-0.6	-0.9	0.5	-0.4	0.7
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.9	-0.9	0.1	0.9	-0.9	0.5
Angina	1.2	1.6	4.2	1.3	-0.2	-0.5	1.3	-2.1
Medication for hormone replacement therapy	0.5	0.5	1.4	0.4	0.0	-1.0	0.3	1.2
Vitamin and mineral supplements	0.0	0.0	0.1	0.1	-0.2	0.3	0.1	0.2
Supplements: Zinc	0.2	0.3	0.7	-0.3	-0.9	-0.5	-0.4	0.2
Medication: Co-codamol	3.0	3.4	4.8	-2.2	-1.2	2.0	-1.9	1.8
Medication: Metformin	0.6	0.8	1.5	-1.2	-0.3	1.0	-1.2	0.4
Diabetes (father)	0.4	0.4	0.7	-0.8	0.8	0.4	-0.7	0.6
Diabetes (mother)	0.4	0.6	0.7	0.7	0.8	0.8	0.8	-0.6
Severe depression (siblings)	0.6	0.7	2.6	-0.3	-0.9	1.6	-0.2	-0.3
Pack years adult smoking proportion	0.9	1.4	2.4	-1.3	-0.9	1.0	-1.5	1.2
Impedance of leg (right)	2.0	9.6	19.5	4.0	2.8	-1.8	4.4	-1.3
Leg fat-free mass (left)	1.0	5.5	12.7	-3.1	-1.7	1.6	-3.6	0.5
Trunk fat percentage	0.7	2.9	7.3	1.5	1.8	0.4	1.2	2.7
Hand grip strength (right)	0.8	2.1	8.7	-0.9	-0.1	-0.6	-0.6	-3.0
Townsend deprivation index at recruitment	0.1	0.1	0.3	-0.5	-0.1	-0.0	-0.4	0.4
Current tobacco smoking	1.3	2.1	4.3	-1.8	-2.1	0.9	-1.4	0.5
Average weekly fortified wine intake	0.3	0.4	0.8	0.5	0.8	0.3	0.4	-0.9
Maternal smoking around birth	0.5	0.7	1.0	0.9	1.0	-0.3	0.8	-0.9
Fed-up feelings	0.3	0.6	1.7	0.5	0.6	-1.3	0.3	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.9	-1.7	0.5	0.3	-1.7	-0.8
Relative age voice broke	1.4	2.1	8.5	0.7	-0.3	-2.9	1.1	0.0
Taking other prescription medications	1.6	2.4	3.3	1.8	1.6	0.6	1.8	-1.6
Age when periods started (menarche)	0.8	2.0	5.1	1.2	1.0	-2.3	1.3	-0.9
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.7	0.9	-0.7	-0.7	0.7	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	3.8	0.6	1.5	0.5	0.6	1.9
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	3.0	-1.7	-0.7	-0.1	-1.6	1.3
Qualifications: CSEs or equivalent	1.6	2.0	7.2	-0.7	-1.3	-0.3	-0.9	2.7
Serious illness, injury or assault to yourself	1.1	1.3	3.0	1.1	0.3	-1.7	1.0	-1.2
High blood pressure	0.4	1.1	3.2	0.9	-0.4	-1.8	0.9	-0.8
Hayfever, allergic rhinitis or eczema	0.5	1.0	3.5	0.2	-0.6	-1.0	0.4	1.9
Multivitamins +/- minerals	0.2	0.2	0.6	-0.3	0.8	0.3	-0.1	0.5
Stomach or abdominal pain in last month	1.2	1.5	2.6	-1.6	0.3	0.8	-1.5	-1.4
Supplements: Glucosamine	0.5	0.7	1.3	1.0	1.1	-0.4	1.0	-0.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.9	-0.1	1.0	-0.0	-0.1	0.3
Medication: Atenolol	0.1	0.1	0.2	-0.1	-0.1	0.0	-0.3	0.5
Medication: Levothyroxine sodium	0.5	0.9	1.3	-0.9	-0.9	0.7	-1.0	1.1
Sitting height	1.3	9.4	15.7	-3.5	-2.5	3.4	-4.0	0.7
Chronic bronchitis/emphysema (father)	0.4	0.4	1.1	-0.6	0.1	1.0	-0.5	0.7
High blood pressure (mother)	0.3	0.4	1.2	-0.6	-0.0	-1.1	-0.4	0.3
Body mass index (BMI)	0.3	1.2	2.6	-1.0	0.3	0.7	-1.3	1.6
Impedance of leg (left)	1.3	6.4	13.4	3.2	2.5	-1.2	3.7	-0.8
Leg predicted mass (left)	1.1	5.9	13.5	-3.2	-1.7	1.7	-3.7	0.6
Trunk fat mass	0.4	1.6	5.7	0.2	1.2	0.9	-0.1	2.4
Waist circumference	0.7	2.4	4.2	-1.6	-1.2	0.7	-1.8	2.1
Number of incorrect matches in round	0.5	0.9	2.2	-0.1	0.6	1.2	-0.5	1.5
Past tobacco smoking	2.9	5.3	13.3	2.4	1.5	0.4	2.2	3.6
Alcohol usually taken with meals	0.6	1.0	2.3	0.5	-0.6	-1.3	0.5	1.5
Nervous feelings	0.2	0.3	1.0	-0.3	1.0	-0.6	-0.0	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.6	-0.3	-0.8	0.0	-0.4	0.1
Hearing difficulty/problems with background noise	1.0	1.6	6.1	-0.0	1.1	-0.8	0.1	-2.5
Hair/balding pattern: Pattern 2	0.2	0.3	1.1	0.2	0.1	-1.1	-0.1	-0.3
Had menopause	0.9	1.1	2.2	1.3	-0.4	-1.5	1.1	-0.3
Had other major operations	1.7	2.0	4.0	1.0	-1.2	-2.0	0.9	-1.7
Forced vital capacity (FVC)	1.9	7.4	22.2	2.0	1.1	-2.2	2.1	-4.7
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	7.1	0.5	0.3	0.1	0.5	2.7
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	3.2	-0.2	0.4	0.6	-0.2	-1.8
Qualifications: None of the above	0.0	0.0	0.1	-0.0	-0.3	-0.1	-0.2	0.2
Financial difficulties in last 2 years	1.8	2.5	6.3	-2.5	-0.2	1.0	-2.2	0.1
Mouth/teeth dental problems	0.1	0.2	0.4	0.5	0.4	-0.0	0.7	-0.1
Heart attack	0.8	1.0	2.4	-0.7	-0.8	1.5	-0.7	-1.0
Allergy	0.9	2.0	6.4	-0.4	1.5	1.0	-0.4	-2.5
Pain all over the body in last month	0.5	0.5	1.6	-0.4	-0.7	0.0	-0.4	1.3
Diabetes (self-reported)	0.3	0.4	1.4	-0.5	0.6	1.2	-0.3	0.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.3	-0.3	-1.2	-0.4	-0.6	1.1
Medication: Ramipril	0.6	0.8	1.6	-0.1	-1.0	-1.2	0.2	-1.3
Medication: Simvastatin	0.4	0.6	1.3	0.9	0.3	-0.4	0.8	-1.1
Fluid intelligence score	1.1	2.2	4.7	-1.9	-2.2	0.0	-1.6	-0.6
Illnesses of siblings	0.6	0.8	1.4	-1.2	0.1	1.2	-1.0	0.4
Neuroticism score	0.3	0.6	2.3	0.4	1.5	-0.7	0.4	-0.2
Weight	0.6	2.8	6.2	-2.2	-0.6	1.2	-2.5	1.1
Impedance of arm (right)	1.4	6.7	13.5	3.7	2.5	-0.6	3.7	0.2
Arm fat percentage (right)	0.5	2.0	5.5	0.6	1.8	0.8	0.4	2.3
Trunk fat-free mass	1.5	8.5	17.7	-4.0	-2.4	1.6	-4.2	-0.7
Hip circumference	0.5	2.3	7.0	-1.3	-0.6	0.2	-1.6	2.6
Time employed in main current job	0.3	0.4	1.0	-0.3	0.7	0.5	-0.1	1.0
Alcohol intake versus 10 years previously	0.2	0.3	0.8	-0.4	0.9	-0.3	-0.4	0.1
Father’s age at death	1.8	2.4	7.9	-1.3	-0.6	0.0	-1.3	2.8
Worrier / anxious feelings	0.4	0.7	1.7	-0.8	-1.3	-0.3	-0.9	0.2
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	3.7	-1.8	-1.0	0.5	-1.9	1.8
Falls in the last year	0.9	1.2	2.3	0.8	0.9	-1.5	0.6	1.4
Hair/balding pattern: Pattern 3	0.5	0.8	2.5	0.4	-0.8	-1.6	0.5	-0.7
Number of live births	0.4	0.5	2.3	-0.3	0.3	-0.0	-0.2	-1.5
Forced expiratory volume in 1-second (FEV1)	2.0	6.9	23.7	1.6	1.6	-1.7	1.6	-4.9
Pulse rate	0.3	0.5	1.3	0.8	-0.1	-0.3	0.6	1.2
Happiness	0.2	0.2	0.7	-0.2	0.2	-0.6	-0.2	-0.9
Noisy workplace	0.6	0.8	2.3	-0.7	0.6	1.5	-0.7	0.4
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.5	-1.8	-0.7	1.3	-1.9	-0.2
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	4.2	-2.0	-0.6	1.7	-2.0	-0.3
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	-0.4	0.5	0.3	-0.3	0.2
Asthma	0.7	1.3	3.1	0.1	-1.1	-1.5	0.1	1.8
Medication: Ibuprofen (e.g. Nurofen)	3.4	4.3	8.7	-2.4	-0.9	0.6	-2.5	2.9
Medication: Cholesterol lowering	0.2	0.3	0.6	0.3	0.4	0.7	0.4	-0.8
Depression (self-reported)	3.6	4.3	6.5	2.5	2.5	-0.7	2.3	-1.6
Medication: Lansoprazole	0.2	0.2	0.4	-0.4	0.2	0.4	-0.6	-0.4
Prospective memory result	0.4	0.5	1.4	-0.4	-0.3	1.2	-0.8	-0.3
Lung cancer (father)	1.2	1.4	2.3	-1.5	-0.6	1.0	-1.5	1.0
Illnesses of mother	0.4	0.5	1.0	0.9	0.1	-0.5	0.6	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	14.1	0.3	1.4	-0.2	0.2	-3.8
Pulse wave Arterial Stiffness index	0.4	0.5	1.2	0.6	0.7	-1.1	0.7	0.2
Impedance of arm (left)	1.2	5.7	12.0	3.5	2.1	-0.4	3.4	0.8
Arm fat mass (right)	0.2	0.9	2.8	-0.3	1.0	0.7	-0.6	1.7
Trunk predicted mass	1.5	8.6	18.1	-4.0	-2.4	1.6	-4.3	-0.6
Standing height	0.5	4.9	8.9	-2.7	-2.2	1.4	-3.0	-1.2
Length of working week for main job	1.5	1.6	3.1	-1.8	-1.2	0.0	-1.7	1.0
Exposure to tobacco smoke at home	0.3	0.3	0.8	0.2	0.9	0.3	0.3	-0.7
Breastfed as a baby	0.4	0.5	1.2	-0.2	-0.2	-1.1	-0.0	-1.1
Tense / ‘highly strung’	0.3	0.5	1.1	0.1	1.1	1.0	0.0	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.4	0.3	1.0	-1.2	0.4	-1.6
Hair/balding pattern: Pattern 4	0.4	1.1	1.8	-1.3	-0.9	1.3	-1.1	0.1
Birth weight of first child	0.9	1.6	3.9	-1.1	-2.0	0.7	-1.2	1.0
Peak expiratory flow (PEF)	0.9	2.1	7.5	-1.2	-0.5	0.5	-1.1	-2.7
Pulse wave reflection index	0.3	0.3	0.8	-0.9	0.0	0.3	-0.7	0.5
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	-0.3	-0.8	-0.0	-0.3	0.4
Loud music exposure frequency	0.4	0.4	1.1	-0.6	1.0	0.2	-0.8	-0.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	4.4	-1.5	-2.1	0.4	-1.0	0.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.7	-0.6	-0.2	0.5	-0.8	0.7
Blood clot in the leg (DVT)	0.2	0.2	1.1	0.1	-0.1	-1.1	0.2	0.2
Medication: Paracetamol	2.2	3.6	11.8	-1.3	-0.4	1.4	-1.6	3.4
Headache pain in last month	0.2	0.4	0.7	-0.6	-0.4	0.4	-0.7	0.9
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.8	0.0	-0.4	-0.7	-0.0	0.9
Glaucoma (self-reported)	0.6	0.7	1.8	-0.2	0.7	1.3	-0.3	-1.1
Gout (self-reported)	0.7	1.0	4.0	0.1	0.5	0.7	0.3	-2.0
Hypothyroidism/myxoedema (self-reported)	0.6	1.3	2.3	-1.3	-1.0	0.7	-1.5	0.9
Medication: Amlodipine	0.1	0.2	0.6	-0.4	0.3	-0.2	-0.4	0.7
Medication: Ventolin 100micrograms inhaler	1.3	1.7	3.0	1.5	-0.6	-1.7	1.5	0.8
Birth weight	1.6	3.4	5.7	-2.3	-1.7	1.6	-2.4	0.9
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.2	1.0	0.7	-0.9	1.1	0.1
High blood pressure (siblings)	1.9	2.7	3.7	1.9	1.4	-1.6	1.8	-1.5
Forced vital capacity (FVC), Best measure	0.8	3.1	12.5	0.9	1.0	-0.7	0.8	-3.5
Body fat percentage	0.6	2.5	7.5	1.1	1.7	0.3	0.9	2.7
Leg fat percentage (right)	0.7	2.7	5.0	1.6	2.2	-0.6	1.5	1.8
Arm fat-free mass (right)	1.5	7.5	16.6	-3.8	-2.2	1.4	-4.1	-0.0
Exposure to tobacco smoke outside home	0.2	0.2	0.7	0.9	-0.2	0.1	0.5	0.1
Comparative body size at age 10	0.5	1.3	2.0	-1.4	-0.2	1.0	-1.3	1.4
Number of full brothers	0.3	0.4	1.1	-0.7	-1.0	-0.4	-0.5	0.1
Worry too long after embarrassment	0.2	0.4	0.7	-0.8	0.0	0.0	-0.8	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	4.7	0.6	1.4	-0.4	0.4	-2.2
Wheeze or whistling in the chest in last year	1.9	3.3	4.9	-2.0	-2.0	0.3	-1.8	2.2
Number of children fathered	0.8	0.9	1.9	1.4	-0.3	-0.9	1.3	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	1.4	-0.0	0.0	1.2	-0.2	0.3
Age at first live birth	0.3	0.6	2.5	-0.0	-0.6	1.6	-0.2	0.4
Pulse wave peak to peak time	0.6	0.7	1.3	-0.8	-0.9	1.1	-0.9	-0.0
Health satisfaction	1.5	1.9	3.1	1.4	1.8	-1.0	1.4	1.2
Shortness of breath walking on level ground	0.2	0.2	1.1	0.1	-0.1	0.1	-0.2	1.1
Qualifications: College or University degree	0.4	1.3	2.0	-1.3	-0.6	1.2	-1.4	-1.1
Eye problems/disorders: None of the above	1.5	1.8	4.3	-0.5	0.9	1.6	-1.0	2.1
Mouth/teeth dental problems: Loose teeth	0.6	0.8	2.6	0.2	-0.6	-0.9	0.1	1.6
Emphysema/chronic bronchitis	0.9	1.0	3.3	0.7	-0.4	-1.8	0.9	0.5
Medication for pain relief, constipation, heartburn	2.9	4.9	9.0	2.1	1.3	-2.0	2.4	-3.0
Neck or shoulder pain in last month	2.3	3.3	4.5	-1.8	-2.1	1.4	-1.9	1.8
Medication: Blood pressure	0.1	0.2	0.5	0.0	0.4	0.6	-0.1	-0.7
Angina (self-reported)	1.2	1.6	4.3	1.3	-0.1	-0.4	1.3	-2.1
Migraine (self-reported)	0.2	0.3	0.9	0.6	0.4	0.0	0.2	-0.9
Medication: Ibuprofen	4.2	5.0	12.2	-2.4	-0.2	1.0	-2.5	3.5
Medication: Allopurinol	0.7	1.0	3.1	0.2	1.1	0.3	0.5	-1.8
Medication: Omeprazole	0.3	0.3	0.6	0.4	0.8	0.6	0.5	-0.4
Medication: Seretide 50 evohaler	0.4	0.4	0.9	0.9	0.3	-0.4	0.9	0.4
Mean time to correctly identify matches	0.3	0.6	2.6	0.1	0.6	0.1	0.2	1.6
Heart disease (mother)	0.3	0.4	0.6	-0.8	-0.3	0.8	-0.5	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.1	1.0	0.4	-0.6	0.9	-0.1
Whole body fat mass	0.3	1.1	4.0	0.1	1.1	0.7	-0.2	2.0
Leg fat mass (right)	0.2	0.8	2.3	-0.0	1.3	0.3	-0.2	1.5
Arm predicted mass (right)	1.3	6.5	14.1	-3.5	-2.1	1.4	-3.8	-0.2
Pulse rate, automated reading	0.2	0.7	1.4	-0.5	-0.7	1.1	-0.4	1.2
Alcohol intake frequency.	0.5	1.1	4.5	0.3	0.6	0.7	-0.0	2.1
Comparative height size at age 10	0.6	3.3	4.6	-1.8	-1.6	2.1	-2.1	1.2
Number of full sisters	0.6	0.8	1.7	-0.8	1.1	1.3	-0.5	-0.3
Suffer from ‘nerves’	0.9	1.4	2.9	0.9	1.1	-1.7	1.3	0.6
Overall health rating	0.8	1.8	6.9	-0.6	-0.8	-0.5	-0.8	2.6
Chest pain or discomfort	0.7	1.0	2.0	-1.4	-1.1	-0.6	-1.3	0.2
Had major operations	0.8	0.9	1.7	0.7	0.4	-1.0	1.0	-1.3
Age at last live birth	1.0	1.5	3.7	-0.9	-1.2	1.9	-1.0	0.7
Family relationship satisfaction	0.7	0.8	1.7	-1.1	0.0	1.3	-1.2	0.3
Leg pain on walking	2.6	3.3	6.0	2.4	1.5	-1.4	2.4	0.3
Qualifications: NVQ or HND or HNC or equivalent	2.2	2.6	6.4	1.7	2.5	-1.0	1.6	-0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.0	0.2	-1.0	-0.1	0.5	-0.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.4	0.5	-0.7	0.1	0.4	0.3
Medication: Aspirin	0.3	0.4	0.7	-0.4	-0.8	0.8	-0.5	-0.6
Supplements: Vitamin C	1.1	1.3	2.9	0.5	-0.7	-1.6	0.5	-1.7
Knee pain experienced in last month	0.6	0.9	1.4	1.2	0.9	-0.4	1.1	0.9
Hypertension (Self-reported)	0.1	0.4	1.0	0.4	-0.6	-1.0	0.4	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.6	-0.5	-1.3	0.6	-0.3	-0.1
Illnesses of father: Heart disease	0.1	0.1	0.2	0.2	-0.4	0.1	-0.0	-0.5
Illnesses of siblings: Diabetes	0.6	0.7	1.6	-0.5	-0.4	1.0	-0.8	1.3
Smoking status: Previous	1.8	2.7	10.2	-1.1	-0.5	-0.7	-1.1	-3.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.4	-0.7	-1.2	0.4	-0.7	-0.6
Whole body fat-free mass	1.4	8.2	17.8	-3.9	-2.2	1.7	-4.2	-0.1
Leg fat-free mass (right)	1.6	8.5	18.6	-3.8	-2.2	2.0	-4.3	0.8
Arm fat percentage (left)	0.5	2.0	7.0	0.5	1.6	0.6	0.2	2.6
Average weekly red wine intake	0.2	0.4	1.1	0.0	0.6	-1.1	-0.0	-0.5
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.1	-1.3	-0.7	0.2	-1.4	0.4
Mood swings	0.3	0.5	1.2	-1.0	0.1	0.1	-1.1	0.6
Loneliness, isolation	1.1	1.5	2.5	-1.6	-1.3	0.3	-1.4	1.1
Long-standing illness, disability or infirmity	1.1	1.7	2.5	1.4	0.4	-1.4	1.6	1.4
Ever had bowel cancer screening	1.0	1.2	1.9	1.2	0.2	-1.2	1.0	-1.4
Diabetes diagnosed by doctor	0.1	0.1	0.3	-0.5	0.3	0.5	-0.3	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	3.9	-1.8	-0.4	2.0	-1.9	0.6
Friendships satisfaction	1.4	1.8	3.7	0.7	1.9	-1.6	0.7	-1.3
Qualifications: nursing, teaching	0.7	1.1	2.0	-1.1	-1.4	0.4	-1.4	0.3
Commuting to job workplace: Walk	0.9	1.0	3.3	0.8	0.3	-1.8	0.8	-0.3
Eye problems/disorders: Cataract	2.7	3.1	6.8	0.8	-1.1	-2.6	1.2	-2.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.6	-0.2	-0.7	-0.8	-0.5	-0.7
Medication for cholesterol	0.2	0.3	0.7	0.8	0.3	0.3	0.6	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.2	-1.1	-0.4	0.7	-1.0	1.5
Back pain experienced in last month	0.3	0.4	1.6	-0.4	0.0	-1.3	-0.0	0.3
Mineral and other dietary supplements	1.4	1.8	4.0	-1.6	-2.0	0.4	-1.6	0.4
Breast cancer (self-reported)	0.1	0.1	0.4	0.0	-0.2	-0.7	0.2	-0.1
Asthma (self-reported)	0.6	1.2	2.7	0.2	-1.0	-1.7	0.2	1.4
Osteoporosis (self-reported)	0.7	0.9	1.3	1.2	1.1	0.1	1.0	-1.0
Osteoarthritis (self-reported)	1.7	2.2	3.0	1.6	1.6	-0.8	1.5	1.7
Medication: Aspirin	0.2	0.3	0.7	-0.3	-0.7	0.8	-0.4	-0.3
Medication: Gliclazide	0.4	0.5	1.7	-0.6	0.4	0.4	-0.4	1.3
Illnesses of father: None of the above (group 1)	0.1	0.2	0.3	-0.5	-0.2	0.4	-0.4	-0.5
Smoking status: Current	1.2	1.9	3.6	-1.8	-1.9	0.8	-1.4	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.6	5.6	11.6	2.1	3.4	-0.0	2.3	-2.6
Whole body water mass	1.4	8.0	17.6	-3.9	-2.2	1.7	-4.2	-0.1
Leg predicted mass (right)	1.7	8.8	19.2	-3.8	-2.3	2.1	-4.4	0.8
Arm fat mass (left)	0.2	0.9	2.8	-0.4	0.7	0.6	-0.7	1.7
Number of self-reported non-cancer illnesses	0.2	0.3	1.4	0.1	-1.2	0.2	0.0	-0.1
Average weekly champagne plus white wine intake	0.3	0.5	2.1	-0.0	0.0	-1.5	-0.1	0.5
Miserableness	1.5	2.7	5.2	1.8	2.3	-0.2	1.9	-1.1
Guilty feelings	0.4	0.6	1.5	-1.2	0.3	0.5	-1.2	-0.3
Wears glasses or contact lenses	0.4	0.4	0.8	-0.9	0.1	0.5	-0.9	0.5
Ever taken oral contraceptive pill	0.3	0.3	1.1	0.2	1.0	-0.3	0.3	-0.6
Hearing aid user	1.0	1.2	3.5	-1.0	0.7	1.9	-0.9	-0.2
Mother’s age at death	0.3	0.3	1.3	0.3	0.3	0.2	0.4	-1.2
Financial situation satisfaction	1.0	1.3	4.9	-0.8	2.2	0.6	-0.6	-0.4
Tinnitus: Yes, now most or all of the time	2.6	3.0	12.6	0.3	1.1	0.9	0.3	-3.6
Commuting to job workplace: Public transport	0.9	1.1	3.2	0.1	1.8	1.3	-0.2	0.6
Eye problems/disorders: Glaucoma	0.5	0.6	1.9	0.4	0.2	0.8	0.5	-1.4
Medication: Blood pressure	0.3	0.7	2.4	-0.1	-0.4	-1.5	0.0	-0.9
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.3	-0.1	-0.3	0.4	0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.9	0.0	1.0	0.4	0.1	0.3
High cholesterol (Self-reported)	0.1	0.2	0.4	0.2	-0.5	-0.3	0.1	-0.7
Medication: Bendroflumethiazide	0.1	0.2	0.4	-0.4	-0.3	0.6	-0.5	0.4
Medication: Paracetamol	1.7	2.6	8.5	-1.1	0.2	1.2	-1.4	2.9
Medication: Lisinopril	0.5	0.7	2.7	0.3	1.6	0.0	0.4	-0.8
Medication: Atorvastatin	1.0	1.3	3.3	-0.7	-1.3	0.7	-0.6	1.8
Illnesses of father: High blood pressure	0.5	0.6	1.5	1.2	0.2	-0.2	0.8	0.8
Alcohol drinker status: Never	0.2	0.3	0.6	0.5	-0.8	-0.6	0.3	0.5
Ever smoked	4.1	7.2	12.2	-3.5	-2.4	0.1	-3.1	-2.9
Basal metabolic rate	1.1	6.0	13.6	-3.3	-1.6	1.6	-3.7	0.2
Leg fat percentage (left)	0.5	2.0	4.1	1.0	1.9	-0.4	1.0	2.0
Arm fat-free mass (left)	1.1	5.6	12.5	-3.3	-1.9	1.1	-3.5	-0.2
Number of operations (self-reported)	1.7	2.5	4.0	1.6	0.6	-2.0	1.6	-1.8
Average weekly beer plus cider intake	0.8	1.2	3.2	0.4	0.9	-0.9	0.8	-1.8
Irritability	0.1	0.1	0.2	-0.1	0.5	0.4	-0.3	0.2
Risk taking	0.1	0.2	0.5	0.0	0.4	-0.5	-0.1	-0.7
Ever had prostate specific antigen (PSA) test	0.6	0.6	1.9	-0.5	-1.4	0.5	-0.7	-0.3
Fractured/broken bones in last 5 years	1.2	1.5	6.3	-0.2	0.8	0.6	-0.2	-2.5
Age started oral contraceptive pill	0.3	0.4	1.0	0.9	-0.4	-0.5	1.0	-0.2
Diastolic blood pressure, automated reading	0.1	0.2	0.5	0.5	0.1	-0.7	0.6	-0.1
Ever depressed for a whole week	0.2	0.3	1.1	-0.0	0.2	0.3	-0.3	-1.1
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.4	0.5	-0.2	-0.2	0.1
Commuting to job workplace: Cycle	0.7	0.9	1.6	-0.8	1.3	-0.7	-0.6	-1.2
Myopia	0.5	0.7	1.8	-0.5	-0.4	-0.6	-0.9	1.3
Vascular/heart problems diagnosed by doctor	0.5	1.2	2.7	-0.8	0.8	1.6	-0.8	1.2
Cholesterol lowering medication	0.4	0.6	1.7	-0.8	-1.3	0.3	-0.8	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	0.8	1.0	0.5	0.8	-0.2
Pain experienced in last month	1.7	2.9	6.2	2.0	2.5	-0.2	1.6	-1.3
Supplements: Calcium	0.9	1.0	2.6	0.7	-0.9	-1.6	0.4	-0.9
Basal cell carcinoma (self-reported)	0.3	0.4	0.9	0.9	-0.2	0.5	0.7	-0.5
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.5	-0.5	-1.0	1.6	-0.5	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.6	0.1	-0.2	-0.7	0.2	0.3
Heart disease (siblings)	0.5	0.6	1.4	0.9	-0.6	-1.2	0.6	-0.3
Alcohol drinker status: Previous	1.0	1.1	4.1	0.2	0.8	0.9	-0.1	2.0
Pack years of smoking	0.4	0.6	1.1	-0.9	-0.6	0.7	-1.0	0.7
Impedance of whole body	1.5	7.7	15.9	3.8	2.6	-1.0	4.0	0.1
Leg fat mass (left)	0.2	0.8	2.5	-0.3	1.1	0.4	-0.4	1.6
Arm predicted mass (left)	1.1	5.5	12.2	-3.3	-1.7	1.2	-3.5	-0.4