Best TWAS P=1.15e-11 · Best GWAS P=3.77e-11 conditioned to 0.0134
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FADS1 | 0.14 | 0.16 | lasso | 2 | 0.16 | 7.2e-19 | -6.3 | 6.3 | 3.0e-10 | -0.56 | 0.03 | 0.97 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | FEN1 | 0.07 | 0.06 | lasso | 4 | 0.06 | 1.1e-07 | -6.3 | -6.2 | 4.8e-10 | 0.56 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Artery Tibial | TMEM258 | 0.08 | 0.05 | lasso | 5 | 0.02 | 1.1e-02 | -6.3 | -6.2 | 6.0e-10 | 0.53 | 0.03 | 0.96 | FALSE |
| 4 | GTEx | Brain Cerebellum | FADS1 | 0.35 | 0.24 | enet | 16 | 0.30 | 2.1e-09 | -6.3 | 6.5 | 8.6e-11 | -0.60 | 0.01 | 0.98 | FALSE |
| 5 | GTEx | Brain Cerebellum | FADS3 | 0.26 | 0.18 | lasso | 4 | 0.14 | 5.7e-05 | -6.3 | 6.4 | 1.2e-10 | -0.62 | 0.03 | 0.84 | FALSE |
| 6 | GTEx | Esophagus Mucosa | FADS1 | 0.11 | 0.00 | lasso | 4 | 0.02 | 1.9e-02 | -6.6 | 5.9 | 3.5e-09 | -0.49 | 0.01 | 0.95 | FALSE |
| 7 | GTEx | Pancreas | FADS1 | 0.17 | 0.13 | lasso | 6 | 0.12 | 1.2e-05 | -6.3 | 6.6 | 4.9e-11 | -0.63 | 0.02 | 0.98 | FALSE |
| 8 | NTR | Blood | C11orf10 | 0.06 | 0.08 | bslmm | 399 | 0.08 | 1.3e-24 | -5.3 | -5.7 | 1.1e-08 | 0.46 | 0.15 | 0.85 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | TMEM258 | 0.14 | 0.16 | lasso | 4 | 0.15 | 4.7e-19 | -5.3 | -5.8 | 7.6e-09 | 0.44 | 0.03 | 0.97 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | FADS1 | 0.08 | 0.08 | enet | 10 | 0.09 | 1.5e-11 | -6.1 | 6.5 | 9.0e-11 | -0.60 | 0.02 | 0.98 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FADS1 | 0.04 | 0.00 | blup | 53 | 0.01 | 1.4e-03 | -2.5 | 5.2 | 2.5e-07 | -0.71 | 0.02 | 0.53 | FALSE |
| 12 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FADS1 | 0.06 | 0.03 | lasso | 4 | 0.04 | 7.4e-03 | -6.3 | 5.1 | 2.9e-07 | -0.58 | 0.02 | 0.70 | FALSE |
| 13 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | FADS1 | 0.20 | 0.01 | blup | 51 | 0.07 | 3.2e-04 | -5.5 | 6.8 | 1.2e-11 | -0.72 | 0.02 | 0.92 | TRUE |
| 14 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FADS2 | 0.02 | 0.01 | blup | 71 | 0.02 | 1.9e-03 | -6.4 | -5.7 | 1.6e-08 | 0.54 | 0.03 | 0.73 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FADS1 | 0.06 | 0.04 | blup | 53 | 0.03 | 2.0e-04 | -6.3 | 6.3 | 3.1e-10 | -0.70 | 0.02 | 0.85 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | C11orf10 | 0.02 | 0.02 | blup | 44 | 0.02 | 1.8e-03 | -4.7 | -6.3 | 3.4e-10 | 0.56 | 0.02 | 0.63 | FALSE |