Hub : Traits :

Fasting Glucose

124 significantly associated models · 37 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	26592429	29260106	20	5	9.3e-24	4.2e-25	NaN	NaN	FNDC4 FTH1P3 KHK PPM1G
2	2	168949234	170419444	3	6	2.0e-54	2.6e-99	9.2e-49	52	G6PC2 NOSTRIN SPC25
3	7	43302684	44814172	4	4	5.8e-18	3.5e-53	8.4e-39	28	AC004985.12 GCK POLM YKT6
4	11	46570859	48028343	4	2	4.0e-12	1.3e-12	2.2e-01	97	MADD NR1H3
5	11	60839578	62346131	6	1	1.2e-11	3.8e-11	1.3e-02	86	FADS1

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Triglycerides	49.82	5	4	8.9	-0.90	1.4e-02	FADS1 FNDC4 FTH1P3 PPM1G YKT6
High cholesterol (Self-reported)	13.20	4	3	6.7	-0.82	8.8e-02	FADS1 FNDC4 FTH1P3 PPM1G
Gout (self-reported)	12.31	3	3	6.7	-1.00	1.3e-04	FNDC4 FTH1P3 PPM1G
Alcohol intake frequency.	10.84	4	3	6.7	-0.85	7.0e-02	FNDC4 FTH1P3 PPM1G YKT6
Medication: Allopurinol	10.53	3	3	6.7	-1.00	7.7e-04	FNDC4 FTH1P3 PPM1G
Blood White Count	8.19	6	6	13.3	-0.78	7.4e-03	FADS1 FNDC4 FTH1P3 G6PC2 NOSTRIN PPM1G
Blood Platelet Count	7.91	6	4	8.9	-0.90	6.2e-03	FADS1 FNDC4 FTH1P3 KHK PPM1G YKT6
Pulse rate, automated reading	7.77	5	4	8.9	-0.78	6.7e-02	FADS1 FNDC4 FTH1P3 NR1H3 PPM1G
Trunk predicted mass	7.60	5	5	11.1	0.97	9.7e-05	FNDC4 FTH1P3 G6PC2 NOSTRIN PPM1G
Trunk fat-free mass	7.51	5	5	11.1	0.97	9.2e-05	FNDC4 FTH1P3 G6PC2 NOSTRIN PPM1G
Medication: Atorvastatin	6.95	3	1	2.2	-1.00	7.9e-04	FNDC4 FTH1P3 PPM1G
Whole body water mass	6.91	6	5	11.1	0.95	1.2e-04	FNDC4 FTH1P3 G6PC2 MADD NOSTRIN PPM1G
Arm fat-free mass (left)	6.87	5	5	11.1	0.97	6.3e-05	FNDC4 FTH1P3 G6PC2 NOSTRIN PPM1G
Arm fat-free mass (right)	6.80	6	5	11.1	0.94	1.9e-04	FNDC4 FTH1P3 G6PC2 MADD NOSTRIN PPM1G
Whole body fat-free mass	6.77	6	5	11.1	0.94	1.3e-04	FNDC4 FTH1P3 G6PC2 MADD NOSTRIN PPM1G
Arm predicted mass (left)	6.76	5	5	11.1	0.97	7.6e-05	FNDC4 FTH1P3 G6PC2 NOSTRIN PPM1G
Arm predicted mass (right)	6.64	6	5	11.1	0.94	1.8e-04	FNDC4 FTH1P3 G6PC2 MADD NOSTRIN PPM1G
Cholesterol lowering medication	6.12	3	1	2.2	-1.00	3.8e-03	FNDC4 FTH1P3 PPM1G
Medication: Cholesterol lowering	5.97	3	1	2.2	-1.00	8.9e-04	FNDC4 FTH1P3 PPM1G
Basal metabolic rate	5.91	6	4	8.9	0.95	6.9e-05	FNDC4 FTH1P3 G6PC2 MADD NOSTRIN PPM1G
HbA1C	5.63	4	0	0.0	0.99	8.0e-04	AC004985.12 G6PC2 GCK SPC25
Pulse rate	5.50	3	2	4.4	-0.96	4.0e-02	FADS1 FNDC4 FTH1P3
Forced expiratory volume in 1-second (FEV1), predicted	5.43	2	2	4.4	0.96	8.6e-03	G6PC2 NOSTRIN
Leg fat-free mass (right)	5.26	7	4	8.9	0.94	3.8e-05	FNDC4 FTH1P3 G6PC2 MADD NOSTRIN NR1H3 PPM1G
Leg predicted mass (right)	5.26	7	4	8.9	0.94	4.0e-05	FNDC4 FTH1P3 G6PC2 MADD NOSTRIN NR1H3 PPM1G
Leg fat-free mass (left)	5.13	7	5	11.1	0.94	4.7e-05	FNDC4 FTH1P3 G6PC2 MADD NOSTRIN NR1H3 PPM1G
Leg predicted mass (left)	5.13	7	5	11.1	0.94	4.6e-05	FNDC4 FTH1P3 G6PC2 MADD NOSTRIN NR1H3 PPM1G
LDL Cholesterol	4.94	2	1	2.2	0.00	1.0e+00	FADS1 FNDC4
Diabetes diagnosed by doctor	4.92	3	2	4.4	1.00	1.9e-03	FNDC4 FTH1P3 PPM1G
Type 2 Diabetes (T2D) (2018)	4.88	3	2	4.4	1.00	6.6e-04	FNDC4 FTH1P3 PPM1G
Sitting height	4.72	6	6	13.3	0.97	4.5e-06	FADS1 FNDC4 FTH1P3 G6PC2 NOSTRIN PPM1G
Medication: Simvastatin	4.63	3	1	2.2	-0.64	3.6e-01	FADS1 FNDC4 FTH1P3
Alcohol intake versus 10 years previously	4.39	3	1	2.2	-0.74	2.6e-01	FNDC4 PPM1G YKT6
Standing height	4.37	6	6	13.3	0.96	1.5e-05	FADS1 FNDC4 FTH1P3 G6PC2 NOSTRIN PPM1G
HDL Cholesterol	4.25	2	1	2.2	0.00	1.0e+00	FADS1 NR1H3
Cardiovascular Disease	4.14	5	4	8.9	-0.98	7.6e-04	FNDC4 FTH1P3 KHK NR1H3 PPM1G
Had menopause	4.09	2	1	2.2	0.00	1.0e+00	FTH1P3 PPM1G
Impedance of arm (left)	4.09	2	1	2.2	0.00	1.0e+00	FNDC4 FTH1P3
Diabetes (self-reported)	3.88	3	2	4.4	0.00	1.0e+00	FNDC4 FTH1P3 PPM1G
Impedance of whole body	3.78	2	1	2.2	0.00	1.0e+00	FNDC4 FTH1P3
Height	3.67	9	7	15.6	0.82	5.7e-04	FADS1 FNDC4 FTH1P3 G6PC2 GCK MADD NOSTRIN PPM1G SPC25
Diabetes (father)	3.61	1	0	0.0	0.00	1.0e+00	FNDC4
Impedance of arm (right)	3.61	2	1	2.2	0.00	1.0e+00	FNDC4 FTH1P3
Medication: Metformin	3.56	2	1	2.2	0.00	1.0e+00	FNDC4 FTH1P3
Medication for cholesterol	3.46	1	1	2.2	0.00	1.0e+00	FNDC4
Number of self-reported non-cancer illnesses	3.24	2	1	2.2	0.00	1.0e+00	FNDC4 PPM1G
Weight	3.20	6	3	6.7	0.97	1.6e-05	FNDC4 FTH1P3 G6PC2 MADD NOSTRIN PPM1G
High blood pressure	3.16	3	1	2.2	0.00	1.0e+00	KHK MADD NR1H3
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.13	1	0	0.0	0.00	1.0e+00	KHK
Number of treatments/medications taken	3.08	3	0	0.0	0.00	1.0e+00	FNDC4 FTH1P3 PPM1G
Miserableness	2.92	2	1	2.2	0.00	1.0e+00	MADD NR1H3
Crohns Disease (2017)	2.87	2	1	2.2	0.00	1.0e+00	FNDC4 PPM1G
Hypertension (Self-reported)	2.85	2	1	2.2	0.00	1.0e+00	KHK NR1H3
Vascular/heart problems diagnosed by doctor	2.79	2	1	2.2	0.00	1.0e+00	KHK NR1H3
Lupus	2.77	1	0	0.0	0.00	1.0e+00	G6PC2
Comparative height size at age 10	2.75	6	1	2.2	0.97	2.0e-04	FADS1 FNDC4 FTH1P3 MADD NOSTRIN PPM1G
Mood swings	2.74	1	1	2.2	0.00	1.0e+00	NR1H3
Impedance of leg (right)	2.69	2	1	2.2	0.00	1.0e+00	FNDC4 MADD
Schizophrenia vs Biploar Disorder	2.68	1	0	0.0	0.00	1.0e+00	FNDC4
Impedance of leg (left)	2.62	1	1	2.2	0.00	1.0e+00	FNDC4
Medication: Bendroflumethiazide	2.57	1	1	2.2	0.00	1.0e+00	NR1H3
Comparative body size at age 10	2.54	2	1	2.2	0.00	1.0e+00	FNDC4 MADD
Medication for cholesterol, blood pressure or diabetes	2.49	1	0	0.0	0.00	1.0e+00	FNDC4
Systolic Blood Pressure	2.46	5	1	2.2	-0.59	3.0e-01	FNDC4 FTH1P3 GCK NR1H3 PPM1G
High blood pressure (siblings)	2.46	2	0	0.0	0.00	1.0e+00	FNDC4 NR1H3
Bipolar Disorder (2018)	2.29	1	0	0.0	0.00	1.0e+00	FNDC4
Depressed Affect (Nagel 2018)	2.25	1	1	2.2	0.00	1.0e+00	NR1H3
Diabetes (mother)	2.16	1	0	0.0	0.00	1.0e+00	FNDC4
Medication: Blood pressure	2.15	2	0	0.0	0.00	1.0e+00	KHK NR1H3
Irritable Bowel Disease (IBD)	2.11	3	1	2.2	0.00	1.0e+00	FNDC4 FTH1P3 PPM1G
Neuroticism (Nagel 2018)	2.05	1	1	2.2	0.00	1.0e+00	NR1H3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.03	1	0	0.0	0.00	1.0e+00	FADS1
Blood Red Count	2.02	2	2	4.4	0.00	1.0e+00	FADS1 FNDC4
Average weekly champagne plus white wine intake	2.02	1	0	0.0	0.00	1.0e+00	FADS1
Illnesses of father: High blood pressure	2.01	1	0	0.0	0.00	1.0e+00	NR1H3
Peak expiratory flow (PEF)	2.00	2	0	0.0	0.98	1.7e-02	G6PC2 NOSTRIN
Guilty feelings	1.98	1	0	0.0	0.00	1.0e+00	NR1H3
Nervous feelings	1.91	2	0	0.0	0.00	1.0e+00	MADD NR1H3
Past tobacco smoking	1.90	1	0	0.0	0.00	1.0e+00	NOSTRIN
Overall health rating	1.90	1	0	0.0	0.00	1.0e+00	FTH1P3
Relative age of first facial hair	1.89	1	1	2.2	0.00	1.0e+00	FNDC4
Stomach or abdominal pain in last month	1.88	1	0	0.0	0.00	1.0e+00	FTH1P3
Crohns Disease (2012)	1.86	2	0	0.0	0.00	1.0e+00	FADS1 FNDC4
Medication for pain relief, constipation, heartburn	1.84	1	0	0.0	0.00	1.0e+00	PPM1G
Suffer from 'nerves'	1.83	2	0	0.0	0.00	1.0e+00	MADD NR1H3
Blood Eosinophil Count	1.82	4	2	4.4	-0.05	9.2e-01	FADS1 FNDC4 G6PC2 NOSTRIN
Deep venous thrombosis (DVT) (self-reported)	1.81	1	0	0.0	0.00	1.0e+00	FADS1
Hand grip strength (left)	1.79	1	0	0.0	0.00	1.0e+00	NOSTRIN
High blood pressure (mother)	1.77	1	0	0.0	0.00	1.0e+00	NR1H3
Medication: Amlodipine	1.76	2	0	0.0	0.00	1.0e+00	KHK NR1H3
Hip circumference	1.74	4	1	2.2	0.57	3.2e-01	FNDC4 KHK MADD NOSTRIN
Worry (Nagel 2018)	1.73	2	1	2.2	0.00	1.0e+00	MADD NR1H3
Hand grip strength (right)	1.68	1	0	0.0	0.00	1.0e+00	FNDC4
Medication: Blood pressure	1.66	1	1	2.2	0.00	1.0e+00	NR1H3
Ever unenthusiastic/disinterested for a whole week	1.64	1	0	0.0	0.00	1.0e+00	FADS1
Neuroticism	1.63	1	1	2.2	0.00	1.0e+00	NR1H3
Mouth/teeth dental problems: Dentures	1.63	1	0	0.0	0.00	1.0e+00	FNDC4
Medication: Ramipril	1.62	1	0	0.0	0.00	1.0e+00	NR1H3
Neuroticism score	1.60	1	1	2.2	0.00	1.0e+00	NR1H3
Age when periods started (menarche)	1.59	1	1	2.2	0.00	1.0e+00	MADD
Hayfever, allergic rhinitis or eczema	1.59	2	0	0.0	0.00	1.0e+00	FNDC4 PPM1G
Alzheimer’s Disease (including proxy)	1.57	1	0	0.0	0.00	1.0e+00	NR1H3
Ever used hormone-replacement therapy (HRT)	1.57	1	0	0.0	0.00	1.0e+00	PPM1G
Systolic blood pressure, automated reading	1.55	1	1	2.2	0.00	1.0e+00	NR1H3
Loud music exposure frequency	1.52	1	0	0.0	0.00	1.0e+00	SPC25
Fed-up feelings	1.48	1	0	0.0	0.00	1.0e+00	NR1H3
Bipolar Disorder or Schizophrenia	1.43	1	0	0.0	0.00	1.0e+00	FNDC4
Asthma (self-reported)	1.42	1	0	0.0	0.00	1.0e+00	FADS1
Irritability	1.40	1	0	0.0	0.00	1.0e+00	FADS1
Asthma	1.36	1	0	0.0	0.00	1.0e+00	FADS1
Number of incorrect matches in round	1.34	1	0	0.0	0.00	1.0e+00	KHK
Arm fat mass (left)	1.34	3	1	2.2	0.00	1.0e+00	FNDC4 KHK MADD
Allergy or Eczema	1.30	2	0	0.0	0.00	1.0e+00	FNDC4 PPM1G
Breast Cancer	1.29	1	0	0.0	0.00	1.0e+00	NR1H3
Fluid intelligence score	1.27	1	0	0.0	0.00	1.0e+00	KHK
Forced expiratory volume in 1-second (FEV1)	1.27	2	0	0.0	0.00	1.0e+00	G6PC2 NOSTRIN
Arm fat mass (right)	1.27	2	0	0.0	0.00	1.0e+00	FNDC4 MADD
Leg fat mass (left)	1.27	2	0	0.0	0.00	1.0e+00	FNDC4 MADD
Forced vital capacity (FVC), Best measure	1.26	1	0	0.0	0.00	1.0e+00	NOSTRIN
Forced vital capacity (FVC)	1.25	2	0	0.0	0.00	1.0e+00	G6PC2 NOSTRIN
Waist circumference	1.24	3	0	0.0	0.00	1.0e+00	FNDC4 KHK MADD
Number of live births	1.24	1	0	0.0	0.00	1.0e+00	FADS1
Trunk fat mass	1.23	2	1	2.2	0.00	1.0e+00	KHK MADD
Heel bone mineral density (BMD) T-score, automated (right)	1.21	1	0	0.0	0.00	1.0e+00	NR1H3
Hair/balding pattern: Pattern 4	1.21	1	1	2.2	0.00	1.0e+00	FADS1
Risk taking	1.21	1	0	0.0	0.00	1.0e+00	KHK
Diastolic blood pressure, automated reading	1.21	1	1	2.2	0.00	1.0e+00	NR1H3
Forced expiratory volume in 1-second (FEV1), Best measure	1.17	1	0	0.0	0.00	1.0e+00	NOSTRIN
Tense / 'highly strung'	1.14	1	0	0.0	0.00	1.0e+00	NR1H3
Leg fat mass (right)	1.14	2	0	0.0	0.00	1.0e+00	FNDC4 MADD
BMI	1.13	2	2	4.4	0.00	1.0e+00	FNDC4 MADD
Waist Hip Ratio (WHR)	1.13	1	0	0.0	0.00	1.0e+00	NOSTRIN
Whole body fat mass	1.07	2	0	0.0	0.00	1.0e+00	KHK MADD
Respiratory disease	1.04	1	1	2.2	0.00	1.0e+00	FADS1
Body mass index (BMI)	1.03	2	0	0.0	0.00	1.0e+00	FNDC4 MADD
Hypothyroidism (self reported)	1.01	1	0	0.0	0.00	1.0e+00	FADS1
Trunk fat percentage	1.01	2	1	2.2	0.00	1.0e+00	KHK MADD
Arm fat percentage (left)	1.01	2	1	2.2	0.00	1.0e+00	KHK MADD
Heel T-Score	0.97	2	2	4.4	0.00	1.0e+00	FADS1 NR1H3
Medication: Lisinopril	0.95	1	0	0.0	0.00	1.0e+00	NR1H3
Mouth/teeth dental problems: Mouth ulcers	0.92	1	0	0.0	0.00	1.0e+00	FADS1
Neuroticism (2016)	0.90	1	0	0.0	0.00	1.0e+00	NR1H3
Lung FVC	0.86	2	0	0.0	0.00	1.0e+00	FADS1 FNDC4
Body fat percentage	0.86	2	0	0.0	0.00	1.0e+00	KHK MADD
Arm fat percentage (right)	0.84	2	0	0.0	0.00	1.0e+00	KHK MADD
Medication: Levothyroxine sodium	0.82	1	0	0.0	0.00	1.0e+00	FADS1
Hypothyroidism/myxoedema (self-reported)	0.76	1	0	0.0	0.00	1.0e+00	FADS1
Qualifications: A levels/AS levels or equivalent	0.75	1	0	0.0	0.00	1.0e+00	KHK
Intelligence (Savage-Jansen 2018)	0.73	1	0	0.0	0.00	1.0e+00	KHK
Tanning	0.60	3	2	4.4	1.00	3.4e-03	FNDC4 FTH1P3 PPM1G
Hair Pigment	0.38	4	2	4.4	-0.89	1.1e-01	FNDC4 FTH1P3 NR1H3 PPM1G

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Visceral Omentum	4	0.197	1.3
GTEx	Adrenal Gland	2	0.138	1.3
GTEx	Artery Coronary	2	0.170	1.3
GTEx	Artery Tibial	4	0.107	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Brain Hypothalamus	1	0.169	1.3
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue (Female)	1	0.061	1.3
GTEx	Cells EBV-transformed lymphocytes	2	0.141	1.3
GTEx	Esophagus Gastroesophageal Junction	3	0.209	1.3
GTEx	Lung	3	0.105	1.3
GTEx	Ovary	1	0.111	1.3
GTEx	Prostate	2	0.241	1.3
METSIM	Adipose	4	0.087	1.3
ROSMAP	Brain Pre-frontal Cortex	8	0.183	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	2	0.122	1.3
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	2	0.184	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	2	0.099	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.060	1.3
GTEx	Adipose Subcutaneous	3	0.086	1.2
GTEx	Artery Aorta	1	0.034	1.2
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.2
GTEx	Brain Cerebellum	3	0.152	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	1	0.084	1.2
GTEx	Cells Transformed fibroblasts	3	0.072	1.2
GTEx	Colon Sigmoid	1	0.069	1.2
GTEx	Colon Transverse	1	0.049	1.2
GTEx	Esophagus Mucosa	3	0.091	1.2
GTEx	Esophagus Muscularis	3	0.093	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Muscle Skeletal	2	0.070	1.2
GTEx	Nerve Tibial	2	0.047	1.2
GTEx	Pancreas	1	0.061	1.2
GTEx	Pituitary	2	0.180	1.2
GTEx	Skin Not Sun Exposed Suprapubic	1	0.041	1.2
GTEx	Skin Sun Exposed Lower leg	3	0.083	1.2
GTEx	Small Intestine Terminal Ileum	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Stomach	1	0.069	1.2
GTEx	Testis	4	0.127	1.2
GTEx	Thyroid	3	0.076	1.2
GTEx	Whole Blood	2	0.101	1.2
NTR	Blood	2	0.083	1.2
YFS	Blood	1	0.022	1.2
CommonMind	Brain Pre-frontal Cortex	6	0.112	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	4	0.092	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	2	0.098	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	1	0.099	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	6	0.148	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	2	0.047	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	1	0.092	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	2	0.069	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	1	0.061	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	3	0.066	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	4	0.079	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.1
GTEx	Liver	0	0.000	1.1
GTEx	Uterus	0	0.000	1.1
GTEx	Vagina	2	0.317	1.1
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	2	0.081	1.1
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.1