Hub : Traits :

Fasting Glucose

124 significantly associated models · 37 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 26592429 29260106 20 5 9.3e-24 4.2e-25 NaN NaN FNDC4 FTH1P3 KHK PPM1G
2 2 168949234 170419444 3 6 2.0e-54 2.6e-99 9.2e-49 52 G6PC2 NOSTRIN SPC25
3 7 43302684 44814172 4 4 5.8e-18 3.5e-53 8.4e-39 28 AC004985.12 GCK POLM YKT6
4 11 46570859 48028343 4 2 4.0e-12 1.3e-12 2.2e-01 97 MADD NR1H3
5 11 60839578 62346131 6 1 1.2e-11 3.8e-11 1.3e-02 86 FADS1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 2.29 1 0 0.0 0.00 1.0e+00 FNDC4
Bipolar Disorder or Schizophrenia 1.43 1 0 0.0 0.00 1.0e+00 FNDC4
Depressed Affect (Nagel 2018) 2.25 1 1 2.2 0.00 1.0e+00 NR1H3
Intelligence (Savage-Jansen 2018) 0.73 1 0 0.0 0.00 1.0e+00 KHK
Neuroticism (Nagel 2018) 2.05 1 1 2.2 0.00 1.0e+00 NR1H3
Schizophrenia vs Biploar Disorder 2.68 1 0 0.0 0.00 1.0e+00 FNDC4
Worry (Nagel 2018) 1.73 2 1 2.2 0.00 1.0e+00 MADD NR1H3
Alzheimer’s Disease (including proxy) 1.57 1 0 0.0 0.00 1.0e+00 NR1H3
Crohns Disease (2017) 2.87 2 1 2.2 0.00 1.0e+00 FNDC4 PPM1G
Irritable Bowel Disease (IBD) 2.11 3 1 2.2 0.00 1.0e+00 FNDC4 FTH1P3 PPM1G
Breast Cancer 1.29 1 0 0.0 0.00 1.0e+00 NR1H3
Crohns Disease (2012) 1.86 2 0 0.0 0.00 1.0e+00 FADS1 FNDC4
HbA1C 5.63 4 0 0.0 0.99 8.0e-04 AC004985.12 G6PC2 GCK SPC25
HDL Cholesterol 4.25 2 1 2.2 0.00 1.0e+00 FADS1 NR1H3
LDL Cholesterol 4.94 2 1 2.2 0.00 1.0e+00 FADS1 FNDC4
Lupus 2.77 1 0 0.0 0.00 1.0e+00 G6PC2
Neuroticism (2016) 0.90 1 0 0.0 0.00 1.0e+00 NR1H3
Triglycerides 49.82 5 4 8.9 -0.90 1.4e-02 FADS1 FNDC4 FTH1P3 PPM1G YKT6
Blood Eosinophil Count 1.82 4 2 4.4 -0.05 9.2e-01 FADS1 FNDC4 G6PC2 NOSTRIN
Blood Platelet Count 7.91 6 4 8.9 -0.90 6.2e-03 FADS1 FNDC4 FTH1P3 KHK PPM1G YKT6
Blood Red Count 2.02 2 2 4.4 0.00 1.0e+00 FADS1 FNDC4
Blood White Count 8.19 6 6 13.3 -0.78 7.4e-03 FADS1 FNDC4 FTH1P3 G6PC2 NOSTRIN PPM1G
Heel T-Score 0.97 2 2 4.4 0.00 1.0e+00 FADS1 NR1H3
BMI 1.13 2 2 4.4 0.00 1.0e+00 FNDC4 MADD
Height 3.67 9 7 15.6 0.82 5.7e-04 FADS1 FNDC4 FTH1P3 G6PC2 GCK MADD NOSTRIN PPM1G SPC25
Waist Hip Ratio (WHR) 1.13 1 0 0.0 0.00 1.0e+00 NOSTRIN
Systolic Blood Pressure 2.46 5 1 2.2 -0.59 3.0e-01 FNDC4 FTH1P3 GCK NR1H3 PPM1G
Allergy or Eczema 1.30 2 0 0.0 0.00 1.0e+00 FNDC4 PPM1G
Cardiovascular Disease 4.14 5 4 8.9 -0.98 7.6e-04 FNDC4 FTH1P3 KHK NR1H3 PPM1G
Hypothyroidism (self reported) 1.01 1 0 0.0 0.00 1.0e+00 FADS1
Respiratory disease 1.04 1 1 2.2 0.00 1.0e+00 FADS1
Type 2 Diabetes (T2D) (2018) 4.88 3 2 4.4 1.00 6.6e-04 FNDC4 FTH1P3 PPM1G
Lung FVC 0.86 2 0 0.0 0.00 1.0e+00 FADS1 FNDC4
Neuroticism 1.63 1 1 2.2 0.00 1.0e+00 NR1H3
Hair Pigment 0.38 4 2 4.4 -0.89 1.1e-01 FNDC4 FTH1P3 NR1H3 PPM1G
Tanning 0.60 3 2 4.4 1.00 3.4e-03 FNDC4 FTH1P3 PPM1G
Hand grip strength (left) 1.79 1 0 0.0 0.00 1.0e+00 NOSTRIN
Number of treatments/medications taken 3.08 3 0 0.0 0.00 1.0e+00 FNDC4 FTH1P3 PPM1G
Relative age of first facial hair 1.89 1 1 2.2 0.00 1.0e+00 FNDC4
Ever used hormone-replacement therapy (HRT) 1.57 1 0 0.0 0.00 1.0e+00 PPM1G
Systolic blood pressure, automated reading 1.55 1 1 2.2 0.00 1.0e+00 NR1H3
Medication: Metformin 3.56 2 1 2.2 0.00 1.0e+00 FNDC4 FTH1P3
Diabetes (father) 3.61 1 0 0.0 0.00 1.0e+00 FNDC4
Diabetes (mother) 2.16 1 0 0.0 0.00 1.0e+00 FNDC4
Impedance of leg (right) 2.69 2 1 2.2 0.00 1.0e+00 FNDC4 MADD
Leg fat-free mass (left) 5.13 7 5 11.1 0.94 4.7e-05 FNDC4 FTH1P3 G6PC2 MADD NOSTRIN NR1H3 PPM1G
Trunk fat percentage 1.01 2 1 2.2 0.00 1.0e+00 KHK MADD
Hand grip strength (right) 1.68 1 0 0.0 0.00 1.0e+00 FNDC4
Fed-up feelings 1.48 1 0 0.0 0.00 1.0e+00 NR1H3
Age when periods started (menarche) 1.59 1 1 2.2 0.00 1.0e+00 MADD
High blood pressure 3.16 3 1 2.2 0.00 1.0e+00 KHK MADD NR1H3
Hayfever, allergic rhinitis or eczema 1.59 2 0 0.0 0.00 1.0e+00 FNDC4 PPM1G
Stomach or abdominal pain in last month 1.88 1 0 0.0 0.00 1.0e+00 FTH1P3
Medication: Levothyroxine sodium 0.82 1 0 0.0 0.00 1.0e+00 FADS1
Sitting height 4.72 6 6 13.3 0.97 4.5e-06 FADS1 FNDC4 FTH1P3 G6PC2 NOSTRIN PPM1G
High blood pressure (mother) 1.77 1 0 0.0 0.00 1.0e+00 NR1H3
Body mass index (BMI) 1.03 2 0 0.0 0.00 1.0e+00 FNDC4 MADD
Impedance of leg (left) 2.62 1 1 2.2 0.00 1.0e+00 FNDC4
Leg predicted mass (left) 5.13 7 5 11.1 0.94 4.6e-05 FNDC4 FTH1P3 G6PC2 MADD NOSTRIN NR1H3 PPM1G
Trunk fat mass 1.23 2 1 2.2 0.00 1.0e+00 KHK MADD
Waist circumference 1.24 3 0 0.0 0.00 1.0e+00 FNDC4 KHK MADD
Number of incorrect matches in round 1.34 1 0 0.0 0.00 1.0e+00 KHK
Past tobacco smoking 1.90 1 0 0.0 0.00 1.0e+00 NOSTRIN
Nervous feelings 1.91 2 0 0.0 0.00 1.0e+00 MADD NR1H3
Had menopause 4.09 2 1 2.2 0.00 1.0e+00 FTH1P3 PPM1G
Forced vital capacity (FVC) 1.25 2 0 0.0 0.00 1.0e+00 G6PC2 NOSTRIN
Heel bone mineral density (BMD) T-score, automated (right) 1.21 1 0 0.0 0.00 1.0e+00 NR1H3
Ever unenthusiastic/disinterested for a whole week 1.64 1 0 0.0 0.00 1.0e+00 FADS1
Diabetes (self-reported) 3.88 3 2 4.4 0.00 1.0e+00 FNDC4 FTH1P3 PPM1G
Medication: Ramipril 1.62 1 0 0.0 0.00 1.0e+00 NR1H3
Medication: Simvastatin 4.63 3 1 2.2 -0.64 3.6e-01 FADS1 FNDC4 FTH1P3
Fluid intelligence score 1.27 1 0 0.0 0.00 1.0e+00 KHK
Neuroticism score 1.60 1 1 2.2 0.00 1.0e+00 NR1H3
Weight 3.20 6 3 6.7 0.97 1.6e-05 FNDC4 FTH1P3 G6PC2 MADD NOSTRIN PPM1G
Impedance of arm (right) 3.61 2 1 2.2 0.00 1.0e+00 FNDC4 FTH1P3
Arm fat percentage (right) 0.84 2 0 0.0 0.00 1.0e+00 KHK MADD
Trunk fat-free mass 7.51 5 5 11.1 0.97 9.2e-05 FNDC4 FTH1P3 G6PC2 NOSTRIN PPM1G
Hip circumference 1.74 4 1 2.2 0.57 3.2e-01 FNDC4 KHK MADD NOSTRIN
Alcohol intake versus 10 years previously 4.39 3 1 2.2 -0.74 2.6e-01 FNDC4 PPM1G YKT6
Number of live births 1.24 1 0 0.0 0.00 1.0e+00 FADS1
Forced expiratory volume in 1-second (FEV1) 1.27 2 0 0.0 0.00 1.0e+00 G6PC2 NOSTRIN
Pulse rate 5.50 3 2 4.4 -0.96 4.0e-02 FADS1 FNDC4 FTH1P3
Qualifications: A levels/AS levels or equivalent 0.75 1 0 0.0 0.00 1.0e+00 KHK
Mouth/teeth dental problems: Dentures 1.63 1 0 0.0 0.00 1.0e+00 FNDC4
Asthma 1.36 1 0 0.0 0.00 1.0e+00 FADS1
Medication: Cholesterol lowering 5.97 3 1 2.2 -1.00 8.9e-04 FNDC4 FTH1P3 PPM1G
Forced expiratory volume in 1-second (FEV1), Best measure 1.17 1 0 0.0 0.00 1.0e+00 NOSTRIN
Impedance of arm (left) 4.09 2 1 2.2 0.00 1.0e+00 FNDC4 FTH1P3
Arm fat mass (right) 1.27 2 0 0.0 0.00 1.0e+00 FNDC4 MADD
Trunk predicted mass 7.60 5 5 11.1 0.97 9.7e-05 FNDC4 FTH1P3 G6PC2 NOSTRIN PPM1G
Standing height 4.37 6 6 13.3 0.96 1.5e-05 FADS1 FNDC4 FTH1P3 G6PC2 NOSTRIN PPM1G
Tense / 'highly strung' 1.14 1 0 0.0 0.00 1.0e+00 NR1H3
Hair/balding pattern: Pattern 4 1.21 1 1 2.2 0.00 1.0e+00 FADS1
Peak expiratory flow (PEF) 2.00 2 0 0.0 0.98 1.7e-02 G6PC2 NOSTRIN
Loud music exposure frequency 1.52 1 0 0.0 0.00 1.0e+00 SPC25
Medication for cholesterol, blood pressure or diabetes 2.49 1 0 0.0 0.00 1.0e+00 FNDC4
Gout (self-reported) 12.31 3 3 6.7 -1.00 1.3e-04 FNDC4 FTH1P3 PPM1G
Hypothyroidism/myxoedema (self-reported) 0.76 1 0 0.0 0.00 1.0e+00 FADS1
Medication: Amlodipine 1.76 2 0 0.0 0.00 1.0e+00 KHK NR1H3
High blood pressure (siblings) 2.46 2 0 0.0 0.00 1.0e+00 FNDC4 NR1H3
Forced vital capacity (FVC), Best measure 1.26 1 0 0.0 0.00 1.0e+00 NOSTRIN
Body fat percentage 0.86 2 0 0.0 0.00 1.0e+00 KHK MADD
Arm fat-free mass (right) 6.80 6 5 11.1 0.94 1.9e-04 FNDC4 FTH1P3 G6PC2 MADD NOSTRIN PPM1G
Comparative body size at age 10 2.54 2 1 2.2 0.00 1.0e+00 FNDC4 MADD
Seen a psychiatrist for nerves, anxiety, tension or depression 2.03 1 0 0.0 0.00 1.0e+00 FADS1
Medication for pain relief, constipation, heartburn 1.84 1 0 0.0 0.00 1.0e+00 PPM1G
Medication: Blood pressure 1.66 1 1 2.2 0.00 1.0e+00 NR1H3
Medication: Allopurinol 10.53 3 3 6.7 -1.00 7.7e-04 FNDC4 FTH1P3 PPM1G
Whole body fat mass 1.07 2 0 0.0 0.00 1.0e+00 KHK MADD
Leg fat mass (right) 1.14 2 0 0.0 0.00 1.0e+00 FNDC4 MADD
Arm predicted mass (right) 6.64 6 5 11.1 0.94 1.8e-04 FNDC4 FTH1P3 G6PC2 MADD NOSTRIN PPM1G
Pulse rate, automated reading 7.77 5 4 8.9 -0.78 6.7e-02 FADS1 FNDC4 FTH1P3 NR1H3 PPM1G
Alcohol intake frequency. 10.84 4 3 6.7 -0.85 7.0e-02 FNDC4 FTH1P3 PPM1G YKT6
Comparative height size at age 10 2.75 6 1 2.2 0.97 2.0e-04 FADS1 FNDC4 FTH1P3 MADD NOSTRIN PPM1G
Suffer from 'nerves' 1.83 2 0 0.0 0.00 1.0e+00 MADD NR1H3
Overall health rating 1.90 1 0 0.0 0.00 1.0e+00 FTH1P3
Hypertension (Self-reported) 2.85 2 1 2.2 0.00 1.0e+00 KHK NR1H3
Forced expiratory volume in 1-second (FEV1), predicted 5.43 2 2 4.4 0.96 8.6e-03 G6PC2 NOSTRIN
Whole body fat-free mass 6.77 6 5 11.1 0.94 1.3e-04 FNDC4 FTH1P3 G6PC2 MADD NOSTRIN PPM1G
Leg fat-free mass (right) 5.26 7 4 8.9 0.94 3.8e-05 FNDC4 FTH1P3 G6PC2 MADD NOSTRIN NR1H3 PPM1G
Arm fat percentage (left) 1.01 2 1 2.2 0.00 1.0e+00 KHK MADD
Mood swings 2.74 1 1 2.2 0.00 1.0e+00 NR1H3
Diabetes diagnosed by doctor 4.92 3 2 4.4 1.00 1.9e-03 FNDC4 FTH1P3 PPM1G
Mouth/teeth dental problems: Mouth ulcers 0.92 1 0 0.0 0.00 1.0e+00 FADS1
Medication for cholesterol 3.46 1 1 2.2 0.00 1.0e+00 FNDC4
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.13 1 0 0.0 0.00 1.0e+00 KHK
Asthma (self-reported) 1.42 1 0 0.0 0.00 1.0e+00 FADS1
Whole body water mass 6.91 6 5 11.1 0.95 1.2e-04 FNDC4 FTH1P3 G6PC2 MADD NOSTRIN PPM1G
Leg predicted mass (right) 5.26 7 4 8.9 0.94 4.0e-05 FNDC4 FTH1P3 G6PC2 MADD NOSTRIN NR1H3 PPM1G
Arm fat mass (left) 1.34 3 1 2.2 0.00 1.0e+00 FNDC4 KHK MADD
Number of self-reported non-cancer illnesses 3.24 2 1 2.2 0.00 1.0e+00 FNDC4 PPM1G
Average weekly champagne plus white wine intake 2.02 1 0 0.0 0.00 1.0e+00 FADS1
Miserableness 2.92 2 1 2.2 0.00 1.0e+00 MADD NR1H3
Guilty feelings 1.98 1 0 0.0 0.00 1.0e+00 NR1H3
Medication: Blood pressure 2.15 2 0 0.0 0.00 1.0e+00 KHK NR1H3
High cholesterol (Self-reported) 13.20 4 3 6.7 -0.82 8.8e-02 FADS1 FNDC4 FTH1P3 PPM1G
Medication: Bendroflumethiazide 2.57 1 1 2.2 0.00 1.0e+00 NR1H3
Medication: Lisinopril 0.95 1 0 0.0 0.00 1.0e+00 NR1H3
Medication: Atorvastatin 6.95 3 1 2.2 -1.00 7.9e-04 FNDC4 FTH1P3 PPM1G
Illnesses of father: High blood pressure 2.01 1 0 0.0 0.00 1.0e+00 NR1H3
Basal metabolic rate 5.91 6 4 8.9 0.95 6.9e-05 FNDC4 FTH1P3 G6PC2 MADD NOSTRIN PPM1G
Arm fat-free mass (left) 6.87 5 5 11.1 0.97 6.3e-05 FNDC4 FTH1P3 G6PC2 NOSTRIN PPM1G
Irritability 1.40 1 0 0.0 0.00 1.0e+00 FADS1
Risk taking 1.21 1 0 0.0 0.00 1.0e+00 KHK
Diastolic blood pressure, automated reading 1.21 1 1 2.2 0.00 1.0e+00 NR1H3
Vascular/heart problems diagnosed by doctor 2.79 2 1 2.2 0.00 1.0e+00 KHK NR1H3
Cholesterol lowering medication 6.12 3 1 2.2 -1.00 3.8e-03 FNDC4 FTH1P3 PPM1G
Deep venous thrombosis (DVT) (self-reported) 1.81 1 0 0.0 0.00 1.0e+00 FADS1
Impedance of whole body 3.78 2 1 2.2 0.00 1.0e+00 FNDC4 FTH1P3
Leg fat mass (left) 1.27 2 0 0.0 0.00 1.0e+00 FNDC4 MADD
Arm predicted mass (left) 6.76 5 5 11.1 0.97 7.6e-05 FNDC4 FTH1P3 G6PC2 NOSTRIN PPM1G

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 3 0.086 1.2
GTEx Adipose Visceral Omentum 4 0.197 1.3
GTEx Adrenal Gland 2 0.138 1.3
GTEx Artery Aorta 1 0.034 1.2
GTEx Artery Coronary 2 0.170 1.3
GTEx Artery Tibial 4 0.107 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.2
GTEx Brain Cerebellum 3 0.152 1.2
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 1 0.169 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.1
GTEx Breast Mammary Tissue (Male) 1 0.084 1.2
GTEx Breast Mammary Tissue (Female) 1 0.061 1.3
GTEx Cells EBV-transformed lymphocytes 2 0.141 1.3
GTEx Cells Transformed fibroblasts 3 0.072 1.2
GTEx Colon Sigmoid 1 0.069 1.2
GTEx Colon Transverse 1 0.049 1.2
GTEx Esophagus Gastroesophageal Junction 3 0.209 1.3
GTEx Esophagus Mucosa 3 0.091 1.2
GTEx Esophagus Muscularis 3 0.093 1.2
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 0 0.000 1.1
GTEx Lung 3 0.105 1.3
GTEx Muscle Skeletal 2 0.070 1.2
GTEx Nerve Tibial 2 0.047 1.2
GTEx Ovary 1 0.111 1.3
GTEx Pancreas 1 0.061 1.2
GTEx Pituitary 2 0.180 1.2
GTEx Prostate 2 0.241 1.3
GTEx Skin Not Sun Exposed Suprapubic 1 0.041 1.2
GTEx Skin Sun Exposed Lower leg 3 0.083 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.2
GTEx Spleen 0 0.000 1.2
GTEx Stomach 1 0.069 1.2
GTEx Testis 4 0.127 1.2
GTEx Thyroid 3 0.076 1.2
GTEx Uterus 0 0.000 1.1
GTEx Vagina 2 0.317 1.1
GTEx Whole Blood 2 0.101 1.2
METSIM Adipose 4 0.087 1.3
NTR Blood 2 0.083 1.2
ROSMAP Brain Pre-frontal Cortex 8 0.183 1.3
YFS Blood 1 0.022 1.2
CommonMind Brain Pre-frontal Cortex 6 0.112 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 2 0.122 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 4 0.092 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 2 0.184 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 2 0.098 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 1 0.099 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.037 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 6 0.148 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 2 0.099 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 2 0.047 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 1 0.092 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 2 0.069 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 2 0.081 1.1
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pancreatic Adenocarcinoma 1 0.061 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 3 0.066 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.060 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.1
The Cancer Genome Atlas Thyroid Carcinoma 4 0.079 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2