[Hub]/) : Traits : HDL Cholesterol :

chr11:115,953,897-117,767,498

Best TWAS P=5.29e-43 · Best GWAS P=1.17e-28 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ZNF259 0.08 0.03 enet 6 0.03 1.2e-04 -9.1 10.3 5.3e-25 -0.89 0.01 0.99 TRUE
2 GTEx Heart Left Ventricle APOA1 0.34 0.20 lasso 7 0.18 5.2e-10 6.9 6.1 8.6e-10 0.29 1.00 0.00 FALSE
3 GTEx Heart Left Ventricle AP006216.12 0.30 0.14 lasso 6 0.15 2.8e-08 6.9 6.3 3.9e-10 0.29 1.00 0.00 TRUE
4 GTEx Testis APOA1 0.25 0.18 lasso 5 0.13 2.3e-06 5.7 -5.8 7.0e-09 0.02 0.91 0.00 TRUE
5 GTEx Testis AP006216.12 0.21 0.15 lasso 2 0.12 6.8e-06 5.7 -5.7 1.4e-08 0.03 0.85 0.01 FALSE
6 METSIM Adipose SIDT2 0.09 0.07 lasso 7 0.07 2.3e-10 4.4 -5.8 6.5e-09 -0.10 1.00 0.00 FALSE
7 The Cancer Genome Atlas Liver Hepatocellular Carcinoma BUD13 0.24 0.03 blup 76 0.08 1.8e-04 3.4 11.6 4.6e-31 -0.17 0.03 0.04 TRUE
8 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ZNF259 0.04 0.03 lasso 3 0.02 8.4e-04 -11.1 11.4 6.9e-30 -0.99 0.00 0.97 TRUE
9 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma BUD13 0.08 0.00 blup 76 0.01 9.2e-02 4.7 13.7 5.3e-43 -0.51 0.02 0.17 TRUE
10 The Cancer Genome Atlas Thyroid Carcinoma SIK3 0.04 0.05 lasso 3 0.04 2.2e-04 5.5 -5.5 3.1e-08 -0.29 0.43 0.02 FALSE