Best TWAS P=5.29e-43 · Best GWAS P=1.17e-28 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ZNF259 | 0.08 | 0.03 | enet | 6 | 0.03 | 1.2e-04 | -9.1 | 10.3 | 5.3e-25 | -0.89 | 0.01 | 0.99 | TRUE |
| 2 | GTEx | Heart Left Ventricle | APOA1 | 0.34 | 0.20 | lasso | 7 | 0.18 | 5.2e-10 | 6.9 | 6.1 | 8.6e-10 | 0.29 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Heart Left Ventricle | AP006216.12 | 0.30 | 0.14 | lasso | 6 | 0.15 | 2.8e-08 | 6.9 | 6.3 | 3.9e-10 | 0.29 | 1.00 | 0.00 | TRUE |
| 4 | GTEx | Testis | APOA1 | 0.25 | 0.18 | lasso | 5 | 0.13 | 2.3e-06 | 5.7 | -5.8 | 7.0e-09 | 0.02 | 0.91 | 0.00 | TRUE |
| 5 | GTEx | Testis | AP006216.12 | 0.21 | 0.15 | lasso | 2 | 0.12 | 6.8e-06 | 5.7 | -5.7 | 1.4e-08 | 0.03 | 0.85 | 0.01 | FALSE |
| 6 | METSIM | Adipose | SIDT2 | 0.09 | 0.07 | lasso | 7 | 0.07 | 2.3e-10 | 4.4 | -5.8 | 6.5e-09 | -0.10 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | BUD13 | 0.24 | 0.03 | blup | 76 | 0.08 | 1.8e-04 | 3.4 | 11.6 | 4.6e-31 | -0.17 | 0.03 | 0.04 | TRUE |
| 8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ZNF259 | 0.04 | 0.03 | lasso | 3 | 0.02 | 8.4e-04 | -11.1 | 11.4 | 6.9e-30 | -0.99 | 0.00 | 0.97 | TRUE |
| 9 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | BUD13 | 0.08 | 0.00 | blup | 76 | 0.01 | 9.2e-02 | 4.7 | 13.7 | 5.3e-43 | -0.51 | 0.02 | 0.17 | TRUE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | SIK3 | 0.04 | 0.05 | lasso | 3 | 0.04 | 2.2e-04 | 5.5 | -5.5 | 3.1e-08 | -0.29 | 0.43 | 0.02 | FALSE |