Hub : Genes

SIK3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Mucosa 0.0980 0.0410 0.00820 0.056 NA 0.017 NA 0.038 1.3e-04 NA 2.4e-02 NA 0.00150
2 YFS Blood 0.0315 0.0112 0.00012 0.010 0.012 0.016 0.012 0.010 2.3e-04 4.1e-05 4.6e-06 6.7e-05 0.00024
3 TCGA Lung Squamous Cell Carcinoma 0.0368 0.0176 0.00025 0.038 0.025 0.026 NA 0.025 3.5e-05 6.2e-04 5.2e-04 NA 0.00072
4 TCGA Thyroid Carcinoma 0.0430 0.0230 0.00210 0.047 0.035 0.032 NA 0.035 2.1e-05 2.3e-04 3.7e-04 NA 0.00022

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.1 0.2 0.8 -0.2 0.9 -0.2 -0.1
Bipolar Disorder or Schizophrenia 0.0 0.1 0.2 0.2 -0.2 -0.4 -0.1
Depressed Affect (Nagel 2018) 1.7 3.6 6.7 2.6 -0.9 1.5 -2.2
Depression (Nagel 2018) 0.7 1.0 2.1 1.4 0.2 -0.0 -1.4
Intelligence (Savage-Jansen 2018) 0.7 2.0 6.3 1.0 2.5 0.7 -0.4
Neuroticism (Nagel 2018) 1.8 4.2 7.3 2.7 -1.1 1.3 -2.6
Schizophrenia (2018) 0.1 0.3 0.9 0.3 -0.9 -0.4 -0.1
Schizophrenia vs Biploar Disorder 2.0 2.6 5.7 1.6 -1.1 2.4 -1.0
Worry (Nagel 2018) 1.2 2.6 5.5 2.1 -0.3 0.6 -2.3
Alzheimer’s Disease (in mother) 0.6 0.7 2.2 0.3 0.7 1.5 -0.1
Alzheimer’s Disease (in father) 0.3 0.3 0.6 0.4 -0.2 0.8 -0.7
Alzheimer’s Disease (including proxy) 0.9 1.2 4.6 0.3 -0.1 2.1 -0.5
Crohns Disease (2017) 0.4 0.9 3.3 -0.5 -1.8 0.2 -0.0
Irritable Bowel Disease (IBD) 1.0 2.5 5.1 -1.4 -2.2 -1.6 0.6
Ulcerative Colitis (UC) 1.8 3.4 5.9 -1.9 -1.7 -2.4 1.2
Major Depression (MDD) 6.5 7.9 12.2 3.5 -2.4 1.3 -3.5
Reaction Time 0.1 0.1 0.4 0.2 0.0 -0.6 0.1
Verbal and Numeric Reasoning (VNR) 0.9 2.2 3.2 1.6 0.9 1.8 -1.4
Breast Cancer 1.6 3.9 13.8 0.4 3.7 0.9 -1.0
Ovarian Cancer 5.2 6.9 9.2 2.8 -1.9 2.6 -3.0
Prostate Cancer 0.5 0.7 1.9 1.4 -0.3 -0.5 -0.6
Age at First Birth 0.5 0.7 2.9 -0.2 1.7 -0.1 -0.0
Bipolar Disorder (2011) 2.4 2.3 4.9 -0.9 2.2 -1.6 0.8
Body Mass Index (BMI) (2010) 0.8 1.1 2.2 -0.9 -1.5 1.0 0.6
Coronary Artery Disease (CAD) 0.6 0.7 0.9 -0.6 0.7 0.9 0.9
Crohns Disease (2012) 0.3 0.5 1.1 -1.0 -0.7 0.5 0.4
Mean Putamen Volume 0.2 0.2 0.7 0.2 -0.8 0.1 -0.1
Fasting Glucose 0.3 0.3 1.0 -0.3 -0.5 1.0 0.1
HbA1C 0.1 0.1 0.3 -0.5 -0.1 0.4 0.1
HDL Cholesterol 9.4 15.7 30.6 4.2 2.5 2.9 -5.5
LDL Cholesterol 2.8 4.5 13.3 1.4 1.4 3.7 -0.8
Lupus 0.3 0.5 1.9 0.2 1.4 -0.2 0.3
Neuroticism (2016) 0.8 1.1 2.6 1.6 -0.4 0.5 -1.2
Primary Biliary Cirrhosis 1.0 1.4 3.2 -1.8 0.5 -0.9 1.2
Rheumatoid Arthritis 1.8 2.5 7.4 -0.6 0.9 -2.7 1.2
Schizophrenia (2014) 0.1 0.2 0.4 0.3 -0.6 -0.5 -0.1
Triglycerides 24.8 40.6 134.6 4.1 -2.4 11.6 -2.3
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.9 -0.1 -0.1 0.9 -0.5
Ulcerative Colitis 0.6 0.8 1.8 -0.2 -0.9 -1.3 -0.8
Blood Eosinophil Count 1.5 11.9 45.7 0.5 -6.8 -0.7 -1.0
Blood Platelet Count 3.0 34.5 58.2 -6.2 0.8 -7.6 6.3
Blood Red Count 0.2 2.1 4.8 1.2 -2.2 0.3 -1.4
Blood White Count 1.8 13.4 21.2 4.6 -3.1 1.6 -4.5
Heel T-Score 0.4 3.0 10.2 -0.2 -3.2 1.4 -0.0
BMI 2.1 12.1 17.8 3.7 -4.2 2.8 -3.0
Height 0.9 18.0 31.8 -4.6 2.2 -3.8 5.6
Waist Hip Ratio (WHR) 2.7 12.0 15.4 3.9 -2.3 3.7 -3.7
Systolic Blood Pressure 0.9 4.3 9.0 0.4 3.0 2.8 -0.4
Smoking Status 0.9 2.2 3.9 1.8 -2.0 0.2 -1.3
Allergy or Eczema 3.0 7.8 15.8 2.4 -4.0 2.7 -1.5
Cardiovascular Disease 2.0 6.6 17.1 2.4 1.4 4.1 -1.3
Hypothyroidism (self reported) 12.2 28.0 32.6 -4.7 5.3 -5.4 5.7
Respiratory disease 0.7 1.6 3.7 1.9 -0.6 1.0 -1.1
Type 2 Diabetes (T2D) (2018) 0.5 0.9 1.5 1.0 -1.0 1.2 -0.6
Lung FEV1/FVC ratio 3.0 15.1 17.2 3.7 -3.6 4.1 -4.2
Lung FVC 3.2 16.1 22.2 -4.2 1.8 -4.7 4.6
Neuroticism 2.2 5.3 10.8 3.3 -1.1 0.8 -2.9
Chronotype (morning person) 0.6 1.4 3.5 -1.1 0.3 -1.9 0.9
Hair Pigment 0.1 3.1 6.8 1.6 -0.7 2.6 -1.6
Tanning 0.1 1.6 3.9 -2.0 0.2 -0.2 1.6
Hand grip strength (left) 0.1 0.4 1.1 -0.1 1.0 0.0 0.6
Number of treatments/medications taken 1.6 2.9 7.1 1.5 -0.9 2.7 -1.1
Average weekly spirits intake 0.1 0.1 0.1 -0.3 0.2 0.1 0.3
Sensitivity / hurt feelings 1.8 3.1 5.8 2.1 -0.9 1.1 -2.4
Frequency of depressed mood in last 2 weeks 1.8 2.5 5.8 2.4 -0.1 0.3 -2.0
Hearing difficulty/problems: Yes 1.8 2.7 4.5 2.1 1.6 0.9 -1.8
Relative age of first facial hair 0.3 0.7 1.0 -1.0 0.5 -1.0 0.7
Other serious medical condition/disability diagnosed by doctor 1.5 1.9 5.9 -0.1 2.4 -0.9 0.9
Ever used hormone-replacement therapy (HRT) 0.3 0.3 1.1 -0.4 1.0 -0.3 0.0
Ever had hysterectomy (womb removed) 0.3 0.3 0.6 0.4 0.0 0.8 -0.7
Systolic blood pressure, automated reading 0.2 0.6 1.4 -0.7 1.2 0.5 0.6
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 1.6 1.3 -0.5 0.9 -1.2
Angina 0.3 0.4 1.1 0.8 0.1 1.0 -0.0
Medication for hormone replacement therapy 2.4 2.7 3.1 1.5 -1.6 1.7 -1.8
Vitamin and mineral supplements 0.3 0.5 0.6 -0.8 0.6 -0.8 0.5
Supplements: Zinc 2.2 2.4 3.3 -1.5 1.4 -1.8 1.4
Medication: Co-codamol 0.5 0.6 2.2 -0.0 1.5 0.1 -0.4
Medication: Metformin 1.1 1.6 2.7 1.3 -0.6 1.6 -1.3
Diabetes (father) 0.3 0.4 1.3 0.3 0.1 1.1 -0.2
Diabetes (mother) 1.6 2.1 3.1 1.3 -1.2 1.8 -1.4
Severe depression (siblings) 0.5 0.5 1.3 0.3 1.1 0.4 0.8
Pack years adult smoking proportion 5.4 8.2 11.8 2.9 -2.3 2.6 -3.4
Impedance of leg (right) 0.0 0.2 0.8 0.4 0.1 0.1 -0.9
Leg fat-free mass (left) 0.1 0.5 1.6 -0.2 -0.4 -0.3 1.3
Trunk fat percentage 0.7 2.7 8.5 1.1 -2.9 0.6 -0.8
Hand grip strength (right) 1.1 3.0 4.6 -1.6 1.7 -1.3 2.1
Townsend deprivation index at recruitment 0.6 0.9 1.0 1.0 -0.9 0.9 -0.8
Current tobacco smoking 3.3 5.3 8.6 2.9 -1.9 1.7 -2.5
Average weekly fortified wine intake 1.2 1.4 2.4 1.0 -1.5 0.8 -1.2
Maternal smoking around birth 4.0 5.8 7.2 2.7 -1.3 2.7 -2.7
Fed-up feelings 1.2 2.1 3.3 1.8 -0.9 1.7 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 2.0 2.7 4.7 2.1 -0.5 1.1 -2.2
Relative age voice broke 0.2 0.3 0.6 -0.8 -0.3 0.4 0.6
Taking other prescription medications 0.3 0.5 1.3 1.1 -0.8 0.3 -0.1
Age when periods started (menarche) 0.5 1.3 2.0 -1.1 -0.3 -1.4 1.4
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.3 0.8 -1.1 0.1 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.4 -0.8 -1.2 0.0 0.6
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.6 0.2 0.8 0.6 0.4
Qualifications: CSEs or equivalent 1.5 1.9 2.5 1.6 -1.5 0.6 -1.6
Serious illness, injury or assault to yourself 0.4 0.5 1.1 1.0 0.7 -0.0 -0.8
High blood pressure 0.3 0.8 1.8 0.4 1.1 1.4 0.2
Hayfever, allergic rhinitis or eczema 2.4 5.2 12.1 1.1 -3.5 2.7 -0.3
Multivitamins +/- minerals 0.5 0.6 1.2 0.8 -0.1 1.1 -0.8
Stomach or abdominal pain in last month 0.4 0.5 0.8 0.6 -0.9 -0.5 -0.7
Supplements: Glucosamine 0.7 0.9 1.8 0.2 -1.2 1.3 -0.5
Diverticular disease/diverticulitis (self-reported) 2.4 2.8 8.9 -0.3 3.0 -1.5 0.2
Medication: Atenolol 0.4 0.5 1.4 0.4 1.2 0.7 -0.2
Medication: Levothyroxine sodium 3.6 6.0 9.6 -2.5 1.6 -2.4 3.1
Sitting height 0.7 5.3 9.0 -2.3 2.1 -1.6 3.0
Chronic bronchitis/emphysema (father) 0.1 0.1 0.2 0.4 0.4 -0.3 -0.1
High blood pressure (mother) 0.5 0.8 2.0 -0.9 0.4 0.3 1.4
Body mass index (BMI) 1.9 8.0 11.6 2.9 -3.4 2.4 -2.5
Impedance of leg (left) 0.0 0.1 0.4 0.1 -0.1 0.2 -0.6
Leg predicted mass (left) 0.1 0.5 1.7 -0.2 -0.4 -0.3 1.3
Trunk fat mass 0.6 2.4 7.8 1.1 -2.8 0.6 -0.6
Waist circumference 3.9 14.1 16.6 4.1 -3.9 3.8 -3.3
Number of incorrect matches in round 0.1 0.2 0.6 -0.3 -0.8 0.2 0.3
Past tobacco smoking 0.3 0.6 1.0 -0.8 -1.0 0.7 0.7
Alcohol usually taken with meals 2.1 3.4 7.5 -1.7 2.7 -1.3 1.3
Nervous feelings 0.8 1.5 3.0 1.4 -0.6 0.9 -1.7
Frequency of tenseness / restlessness in last 2 weeks 1.7 2.7 4.6 2.1 -0.7 1.5 -1.8
Hearing difficulty/problems with background noise 0.9 1.5 2.2 1.5 0.1 1.3 -1.4
Hair/balding pattern: Pattern 2 0.3 0.4 1.6 0.0 -1.3 -0.1 0.3
Had menopause 1.5 1.9 2.9 -1.7 0.8 -1.2 1.6
Had other major operations 0.3 0.3 0.6 0.8 0.0 0.7 -0.4
Forced vital capacity (FVC) 6.4 24.8 31.6 -5.2 3.3 -5.4 5.6
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 4.3 -0.1 -2.1 1.0 -0.2
Ever unenthusiastic/disinterested for a whole week 0.5 0.7 1.1 1.0 -0.3 1.0 -0.7
Qualifications: None of the above 3.1 6.7 10.5 1.8 -3.2 1.7 -3.2
Financial difficulties in last 2 years 2.0 2.7 3.7 1.9 -1.0 1.7 -1.8
Mouth/teeth dental problems 1.4 2.1 2.7 -1.5 1.1 -1.6 1.5
Heart attack 0.0 0.1 0.1 0.4 -0.1 0.3 -0.1
Allergy 1.3 2.9 7.2 -1.2 2.7 -1.7 -0.0
Pain all over the body in last month 0.4 0.4 0.8 0.8 0.9 0.1 -0.2
Diabetes (self-reported) 0.1 0.1 0.5 0.3 -0.1 0.7 -0.1
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 4.0 0.6 -2.0 1.3 -0.4
Medication: Ramipril 0.8 1.1 4.2 -0.1 0.2 2.0 0.3
Medication: Simvastatin 0.7 1.0 3.7 0.2 0.3 1.9 0.2
Fluid intelligence score 1.2 2.4 4.2 1.7 0.7 2.0 -1.5
Illnesses of siblings 2.9 4.1 9.0 -2.0 0.4 -3.0 1.8
Neuroticism score 1.2 2.6 5.7 2.4 -0.3 0.7 -2.0
Weight 0.4 2.0 5.1 1.3 -2.3 1.1 -0.3
Impedance of arm (right) 1.5 6.9 9.9 -2.9 1.2 -3.1 2.8
Arm fat percentage (right) 1.0 3.8 10.8 1.4 -3.3 0.9 -1.2
Trunk fat-free mass 0.1 0.4 1.3 -0.4 0.3 -0.1 1.1
Hip circumference 0.5 2.2 4.3 1.5 -2.1 1.4 -0.6
Time employed in main current job 3.5 4.1 12.7 0.2 -3.6 1.7 -0.9
Alcohol intake versus 10 years previously 0.9 1.3 3.6 -1.0 -0.1 -1.9 0.8
Father’s age at death 1.1 1.5 4.0 -1.1 0.9 -2.0 0.5
Worrier / anxious feelings 1.3 2.5 4.3 2.0 0.9 0.8 -2.1
Frequency of tiredness / lethargy in last 2 weeks 1.7 2.7 5.6 2.4 0.5 1.6 -1.6
Falls in the last year 1.2 1.6 2.4 1.5 -1.5 0.0 -1.4
Hair/balding pattern: Pattern 3 0.3 0.5 1.2 0.4 1.1 0.4 -0.6
Number of live births 2.4 3.3 6.0 2.2 -0.4 1.6 -2.5
Forced expiratory volume in 1-second (FEV1) 3.4 11.4 14.4 -3.6 2.0 -3.8 3.8
Pulse rate 0.3 0.6 1.9 0.4 0.3 -1.4 -0.3
Happiness 1.1 1.4 3.8 2.0 -0.3 0.4 -1.2
Noisy workplace 0.2 0.2 0.7 0.1 0.2 -0.5 0.8
Qualifications: A levels/AS levels or equivalent 1.4 3.1 8.6 -1.1 2.9 -0.4 1.5
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.9 0.2 -0.8 0.9 -0.2
Mouth/teeth dental problems: Dentures 3.2 5.5 6.9 2.5 -1.6 2.6 -2.5
Asthma 1.7 3.3 5.2 2.3 -1.2 2.2 -1.3
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.5 0.1 -0.0 -0.7 -0.4
Medication: Cholesterol lowering 2.8 4.4 11.8 2.0 0.7 3.4 -1.0
Depression (self-reported) 0.2 0.3 0.6 0.7 -0.3 0.3 -0.7
Medication: Lansoprazole 8.5 9.7 15.7 3.6 -1.8 2.5 -4.0
Prospective memory result 1.8 2.2 4.0 -2.0 -0.1 -1.4 1.7
Lung cancer (father) 0.7 0.8 2.9 0.1 -1.7 0.7 0.1
Illnesses of mother 0.7 0.9 1.7 0.8 -1.3 -0.5 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 2.4 7.7 10.6 -2.8 1.5 -3.2 3.2
Pulse wave Arterial Stiffness index 0.7 0.8 2.5 -0.4 0.7 -1.6 0.0
Impedance of arm (left) 2.2 10.0 13.2 -3.5 1.4 -3.6 3.6
Arm fat mass (right) 0.7 2.8 7.6 1.3 -2.8 1.0 -1.0
Trunk predicted mass 0.1 0.4 1.3 -0.4 0.4 -0.1 1.1
Standing height 1.3 12.9 22.9 -3.8 2.4 -2.9 4.8
Length of working week for main job 2.8 3.1 6.1 2.5 -1.3 1.1 -1.9
Exposure to tobacco smoke at home 3.2 3.6 5.1 2.0 -1.2 2.0 -2.3
Breastfed as a baby 0.9 1.1 2.1 -0.7 1.4 -1.1 0.6
Tense / ‘highly strung’ 0.4 0.7 1.4 0.8 -1.2 -0.6 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 3.4 1.8 1.1 -0.5 -0.9
Hair/balding pattern: Pattern 4 0.3 0.6 1.5 0.1 1.2 0.8 -0.5
Birth weight of first child 0.3 0.5 0.7 -0.8 -0.6 -0.7 0.8
Peak expiratory flow (PEF) 0.2 0.5 0.9 0.5 -0.4 0.9 -0.8
Pulse wave reflection index 0.5 0.7 2.6 -0.1 -1.6 -0.1 0.0
Ever highly irritable/argumentative for 2 days 0.8 1.0 2.0 0.1 -0.7 1.4 -1.2
Loud music exposure frequency 0.1 0.1 0.3 0.0 0.4 0.5 -0.3
Qualifications: O levels/GCSEs or equivalent 1.3 2.1 5.9 -0.6 2.4 -1.2 0.8
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 2.9 0.7 -1.7 -0.2 -0.6
Blood clot in the leg (DVT) 0.6 0.8 2.0 -0.5 0.6 -1.4 0.7
Medication: Paracetamol 0.6 0.9 1.9 -0.8 -0.6 -1.4 0.9
Headache pain in last month 0.2 0.4 1.0 -0.3 -1.0 -0.7 0.4
Medication for cholesterol, blood pressure or diabetes 4.5 7.4 17.0 -2.7 -0.8 -4.1 2.2
Glaucoma (self-reported) 1.5 1.7 2.0 1.4 -1.2 1.2 -1.4
Gout (self-reported) 1.1 1.6 2.9 1.4 -0.3 1.7 -1.2
Hypothyroidism/myxoedema (self-reported) 8.1 15.8 22.4 -3.7 3.4 -3.9 4.7
Medication: Amlodipine 0.2 0.3 0.6 0.8 -0.2 0.8 0.1
Medication: Ventolin 100micrograms inhaler 0.3 0.3 0.5 -0.6 0.6 0.4 0.7
Birth weight 1.0 2.1 4.0 -1.4 2.0 -0.4 1.5
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.7 0.8 -0.0 0.5 -0.5
High blood pressure (siblings) 2.2 3.1 7.4 1.6 -0.0 2.7 -1.6
Forced vital capacity (FVC), Best measure 5.6 20.4 26.5 -4.5 2.9 -5.2 5.1
Body fat percentage 1.3 5.1 12.8 1.9 -3.6 1.2 -1.6
Leg fat percentage (right) 3.5 12.8 17.5 3.6 -4.2 2.9 -3.5
Arm fat-free mass (right) 0.1 0.5 0.8 0.9 -0.6 0.8 -0.2
Exposure to tobacco smoke outside home 2.4 3.2 5.4 1.8 -1.4 1.4 -2.3
Comparative body size at age 10 0.4 1.0 1.6 0.7 -1.2 1.3 -0.7
Number of full brothers 1.7 2.2 3.4 1.7 0.3 1.5 -1.8
Worry too long after embarrassment 0.4 0.6 2.0 0.2 1.4 -0.6 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.2 1.1 -0.3 0.4 -0.3
Wheeze or whistling in the chest in last year 3.1 5.6 9.9 3.1 -1.9 1.7 -2.4
Number of children fathered 2.1 2.4 5.7 -2.4 0.7 -0.0 1.9
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.8 -1.4 -0.1 -0.6 0.8
Age at first live birth 0.2 0.4 0.8 0.5 -0.7 0.9 0.2
Pulse wave peak to peak time 0.5 0.6 1.9 0.2 -0.6 1.4 0.2
Health satisfaction 0.4 0.5 1.2 0.8 1.1 0.4 -0.2
Shortness of breath walking on level ground 2.5 2.9 3.7 1.9 -1.6 1.7 -1.5
Qualifications: College or University degree 1.3 4.0 7.8 -1.2 2.8 -1.3 2.3
Eye problems/disorders: None of the above 0.2 0.3 0.5 0.1 0.7 0.5 -0.6
Mouth/teeth dental problems: Loose teeth 1.1 1.3 4.3 0.9 2.1 0.2 -0.5
Emphysema/chronic bronchitis 0.6 0.7 1.5 0.9 1.2 -0.5 -0.5
Medication for pain relief, constipation, heartburn 0.6 1.0 1.7 -1.2 1.3 -0.3 0.9
Neck or shoulder pain in last month 0.3 0.4 0.9 0.5 -0.1 0.7 -1.0
Medication: Blood pressure 1.9 3.3 7.6 1.8 0.5 2.8 -1.4
Angina (self-reported) 0.4 0.5 1.3 0.8 0.1 1.1 -0.1
Migraine (self-reported) 3.8 4.8 10.3 -1.1 1.5 -3.2 2.3
Medication: Ibuprofen 0.2 0.2 0.4 -0.1 0.4 -0.7 -0.3
Medication: Allopurinol 0.9 1.3 1.9 1.4 1.0 1.0 -1.0
Medication: Omeprazole 5.4 6.4 9.3 2.7 -1.5 2.6 -3.1
Medication: Seretide 50 evohaler 0.4 0.4 0.8 0.3 0.9 0.7 -0.4
Mean time to correctly identify matches 0.1 0.2 0.5 0.1 -0.7 -0.5 -0.0
Heart disease (mother) 0.4 0.5 1.4 0.4 0.6 1.2 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.0 0.5 0.4 -0.4 -1.0
Whole body fat mass 0.8 3.3 9.7 1.3 -3.1 1.0 -0.9
Leg fat mass (right) 2.2 8.4 13.5 3.0 -3.7 2.2 -2.4
Arm predicted mass (right) 0.1 0.4 0.8 0.9 -0.6 0.8 -0.0
Pulse rate, automated reading 0.3 1.0 3.0 0.7 -1.7 0.6 -0.1
Alcohol intake frequency. 0.5 1.2 3.6 -0.3 -1.9 -0.9 0.5
Comparative height size at age 10 1.4 7.6 13.0 -2.7 1.0 -3.6 3.0
Number of full sisters 1.3 1.6 2.9 1.1 -0.9 1.7 -1.3
Suffer from ‘nerves’ 0.7 1.2 2.2 1.3 -0.9 -0.0 -1.5
Overall health rating 2.5 5.4 10.7 3.3 0.1 2.3 -2.3
Chest pain or discomfort 0.6 0.8 2.7 1.6 0.0 -0.4 -0.7
Had major operations 0.7 0.8 1.7 1.3 -0.5 0.2 -1.1
Age at last live birth 0.4 0.5 0.9 0.9 -0.7 0.9 0.0
Family relationship satisfaction 0.1 0.1 0.2 0.4 0.1 -0.0 -0.5
Leg pain on walking 0.4 0.5 1.0 1.0 0.4 0.8 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.4 0.6 -0.5 -0.1 -0.4
Commuting to job workplace: Car/motor vehicle 2.3 2.6 5.3 1.6 -0.3 1.6 -2.3
Illness, injury, bereavement, stress in last 2 years 0.0 0.0 0.1 -0.2 -0.2 0.3 -0.1
Medication: Aspirin 0.6 0.8 2.1 1.4 0.7 0.6 -0.6
Supplements: Vitamin C 1.2 1.4 2.1 -1.4 0.4 -1.2 1.4
Knee pain experienced in last month 0.3 0.5 0.8 0.6 -0.8 0.0 -0.9
Hypertension (Self-reported) 0.1 0.4 1.0 0.1 0.6 1.0 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 5.6 6.5 11.8 2.9 -1.9 1.6 -3.4
Illnesses of father: Heart disease 0.6 0.8 3.0 -0.2 1.7 0.2 0.5
Illnesses of siblings: Diabetes 1.3 1.6 2.6 1.5 -1.6 1.1 -0.7
Smoking status: Previous 0.2 0.4 0.8 -0.0 0.8 -0.9 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.5 1.5 -0.5 0.7 -0.0 1.2
Whole body fat-free mass 0.0 0.3 1.1 -0.1 0.0 -0.0 1.0
Leg fat-free mass (right) 0.1 0.7 2.5 -0.5 -0.4 -0.2 1.6
Arm fat percentage (left) 0.8 3.1 10.7 1.0 -3.3 0.5 -0.7
Average weekly red wine intake 0.8 1.2 4.6 -0.5 2.1 0.3 0.1
Handedness (chirality/laterality): Left-handed 1.0 1.2 4.0 -0.8 2.0 0.1 0.4
Mood swings 1.3 2.4 4.3 2.1 -1.5 1.0 -1.4
Loneliness, isolation 1.0 1.4 3.0 1.5 0.1 0.5 -1.7
Long-standing illness, disability or infirmity 2.6 4.0 8.0 2.8 1.3 1.7 -1.8
Ever had bowel cancer screening 1.2 1.4 2.6 1.0 -1.6 0.5 -1.3
Diabetes diagnosed by doctor 0.2 0.3 0.5 0.4 -0.5 0.7 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.1 0.9 0.3 1.1 -0.6
Friendships satisfaction 0.4 0.5 1.0 0.4 -1.0 0.6 -0.6
Qualifications: nursing, teaching 0.8 1.2 1.5 -1.1 1.2 -1.0 1.2
Commuting to job workplace: Walk 0.4 0.4 1.1 0.2 -0.7 1.0 0.1
Eye problems/disorders: Cataract 0.6 0.7 2.2 -0.6 0.3 -0.3 1.5
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.6 1.2 0.4 0.0 -0.5
Medication for cholesterol 1.7 2.5 7.6 -1.0 0.7 -2.8 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.8 1.3 -0.5 0.5 -0.7
Back pain experienced in last month 0.2 0.3 0.4 -0.5 -0.1 -0.6 0.6
Mineral and other dietary supplements 0.2 0.2 0.5 0.7 0.3 -0.3 -0.4
Breast cancer (self-reported) 1.7 2.0 3.2 -1.8 0.8 -1.0 1.8
Asthma (self-reported) 1.6 3.1 5.2 2.3 -1.0 2.2 -1.3
Osteoporosis (self-reported) 0.3 0.3 0.8 -0.7 0.1 -0.2 0.9
Osteoarthritis (self-reported) 0.4 0.6 0.8 0.9 -0.9 0.3 -0.7
Medication: Aspirin 0.3 0.5 0.9 1.0 0.9 0.3 -0.2
Medication: Gliclazide 0.2 0.2 0.6 -0.2 0.5 0.8 -0.2
Illnesses of father: None of the above (group 1) 0.7 0.9 2.2 -1.0 -0.3 -1.5 0.6
Smoking status: Current 2.5 3.9 6.8 2.6 -1.2 1.5 -2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.1 4.0 -1.4 0.6 -2.0 1.5
Whole body water mass 0.0 0.2 0.9 -0.1 0.0 0.0 1.0
Leg predicted mass (right) 0.1 0.7 2.5 -0.4 -0.3 -0.2 1.6
Arm fat mass (left) 0.6 2.7 7.6 1.3 -2.8 0.9 -0.8
Number of self-reported non-cancer illnesses 1.0 1.7 4.9 2.2 -0.2 1.3 -0.7
Average weekly champagne plus white wine intake 2.2 3.0 4.3 -1.9 1.4 -1.5 2.1
Miserableness 2.1 3.7 6.9 2.6 -1.0 1.8 -1.9
Guilty feelings 1.2 1.9 4.9 2.2 0.7 0.4 -1.4
Wears glasses or contact lenses 0.2 0.3 0.5 -0.7 -0.6 -0.4 0.3
Ever taken oral contraceptive pill 0.5 0.6 0.9 -0.8 -0.1 0.9 1.0
Hearing aid user 0.7 0.8 1.1 1.0 0.4 1.0 -1.1
Mother’s age at death 2.0 2.5 4.4 -2.1 1.8 -0.9 1.3
Financial situation satisfaction 1.1 1.3 2.2 1.5 -0.4 1.1 -1.3
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.8 0.5 0.9 -0.4 -0.3
Commuting to job workplace: Public transport 0.1 0.1 0.1 0.0 -0.3 -0.1 0.4
Eye problems/disorders: Glaucoma 1.9 2.3 3.4 1.8 -1.5 1.1 -1.6
Medication: Blood pressure 0.2 0.5 1.7 -0.2 -0.2 1.3 -0.0
Pain type(s) experienced in last month: Hip pain 0.6 0.7 1.4 0.8 -1.2 -0.3 -0.9
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.4 -0.3 0.2 0.7 0.2
High cholesterol (Self-reported) 6.3 11.1 30.0 3.0 1.4 5.5 -1.9
Medication: Bendroflumethiazide 0.2 0.3 1.1 0.1 0.3 1.0 -0.2
Medication: Paracetamol 0.5 0.8 0.9 -0.7 -1.0 -1.0 0.8
Medication: Lisinopril 1.5 1.9 4.6 0.5 -2.1 1.6 -0.7
Medication: Atorvastatin 6.1 7.6 19.0 2.8 0.4 4.4 -1.8
Illnesses of father: High blood pressure 1.7 2.1 2.9 1.5 -0.8 1.6 -1.7
Alcohol drinker status: Never 0.4 0.5 0.8 -0.7 -0.9 -0.7 0.3
Ever smoked 0.3 0.6 1.1 0.6 0.3 -0.9 -1.0
Basal metabolic rate 0.0 0.2 0.6 0.2 -0.6 0.2 0.8
Leg fat percentage (left) 3.2 11.5 17.2 3.2 -4.2 2.9 -3.2
Arm fat-free mass (left) 0.1 0.7 1.4 1.1 -0.4 1.2 -0.5
Number of operations (self-reported) 0.4 0.6 1.3 1.1 -0.5 0.3 -0.9
Average weekly beer plus cider intake 1.0 1.5 2.3 1.5 -1.5 0.5 -1.0
Irritability 0.9 1.6 2.7 1.7 -1.3 0.4 -1.3
Risk taking 1.0 1.5 5.3 -0.2 2.3 -0.7 0.3
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.7 0.5 0.5 -0.0 -0.8
Fractured/broken bones in last 5 years 0.1 0.1 0.2 -0.4 0.4 0.3 0.0
Age started oral contraceptive pill 2.6 3.2 5.1 -2.0 1.2 -1.6 2.2
Diastolic blood pressure, automated reading 0.0 0.1 0.3 -0.2 0.6 0.1 0.5
Ever depressed for a whole week 0.6 0.8 2.2 1.5 0.5 -0.3 -0.7
Unable to work because of sickness or disability 0.5 0.7 1.3 0.4 1.1 -0.5 -1.1
Commuting to job workplace: Cycle 0.7 0.9 1.8 -0.5 1.3 -1.1 0.4
Myopia 2.6 3.8 6.2 1.2 -1.5 2.5 -2.2
Vascular/heart problems diagnosed by doctor 0.4 1.2 2.6 -0.5 -1.4 -1.6 -0.2
Cholesterol lowering medication 5.5 8.1 25.6 2.0 -0.5 5.1 -1.6
Medication: Omeprazole (e.g. Zanprol) 7.4 9.1 12.9 3.1 -2.2 2.9 -3.6
Pain experienced in last month 0.2 0.4 0.7 -0.7 0.8 0.2 0.6
Supplements: Calcium 0.8 0.9 1.6 -1.3 -0.8 -0.1 1.1
Basal cell carcinoma (self-reported) 2.2 2.6 4.7 -1.7 1.3 -1.0 2.2
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.1 0.0 0.2 0.1 0.3
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 1.3 -0.1 1.1 -1.1 0.3
Heart disease (siblings) 1.7 2.0 4.6 1.5 0.5 2.1 -1.1
Alcohol drinker status: Previous 0.6 0.7 1.1 1.1 -1.0 0.0 -0.8
Pack years of smoking 3.9 5.7 8.9 2.3 -2.0 2.1 -3.0
Impedance of whole body 0.5 2.8 4.1 -2.0 0.8 -1.8 1.7
Leg fat mass (left) 2.0 7.7 13.3 2.7 -3.6 2.2 -2.2
Arm predicted mass (left) 0.2 0.8 1.6 1.3 -0.4 1.1 -0.6