TWAS hub - BUD13

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0534	0.0234	0.0023	0.005	0.020	0.008	NA	0.006	0.029	4.9e-05	0.00820	NA	0.018
2	TCGA	Liver Hepatocellular Carcinoma	0.2420	0.1090	0.0058	0.031	0.077	0.074	NA	0.025	0.013	1.8e-04	0.00022	NA	0.024
3	TCGA	Ovarian Serous Cystadenocarcinoma	0.0790	0.0430	0.0072	-0.001	0.008	0.002	NA	-0.001	0.390	9.2e-02	0.24000	NA	0.370

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Triglycerides	126.2	206.8	400.0	-4.0	-14.3	-20.0
HDL Cholesterol	68.9	115.0	189.0	4.7	11.6	13.7
High cholesterol (Self-reported)	26.7	47.4	85.4	-4.0	-6.4	-9.2
Medication: Cholesterol lowering	18.9	29.4	57.6	-2.7	-4.8	-7.6
LDL Cholesterol	14.3	22.7	46.8	-1.0	-4.5	-6.8
Medication: Atorvastatin	12.3	15.2	28.0	-1.1	-4.0	-5.3
Cholesterol lowering medication	11.9	17.5	32.1	-2.2	-4.0	-5.7
Medication for cholesterol, blood pressure or diabetes	11.7	19.4	34.6	1.8	4.5	5.9
Medication: Simvastatin	8.8	12.9	25.6	-1.9	-3.1	-5.1
Illnesses of father: Heart disease	7.2	10.0	13.3	-3.1	-3.6	-2.7
Coronary Artery Disease (CAD)	6.3	7.6	15.9	-1.9	-1.8	-4.0
Cardiovascular Disease	5.0	16.6	26.8	-2.6	-4.0	-5.2
Heart disease (siblings)	4.6	5.7	9.6	-1.6	-2.2	-3.1
Leg pain on walking	3.9	4.8	11.0	-3.3	-0.6	-1.8
Breast cancer (self-reported)	3.8	4.5	7.5	-0.6	2.7	2.4
Prospective memory result	3.7	4.6	9.6	-0.8	1.8	3.1
Friendships satisfaction	3.7	4.6	9.5	0.2	-2.1	-3.1
Heart disease (mother)	3.5	4.3	10.3	-0.7	-1.4	-3.2
Illnesses of siblings: Diabetes	3.5	4.3	12.2	-3.5	0.6	0.4
Serious illness, injury or assault of a close relative in last 2 years	3.4	3.9	5.1	2.2	-1.6	-2.0
Pain type(s) experienced in last month: Hip pain	3.4	4.3	9.1	-0.6	3.0	1.9
Medication: Aspirin	3.3	4.3	8.8	-2.0	-0.2	-3.0
Medication: Aspirin	3.1	4.1	8.0	-2.1	-0.3	-2.8
Illnesses of father: None of the above (group 1)	3.0	3.7	5.4	0.9	2.3	2.2
Pulse rate	2.9	4.9	8.4	-1.2	2.9	2.2
Number of self-reported non-cancer illnesses	2.9	4.9	7.3	-2.6	0.7	-2.7
Number of full brothers	2.8	3.5	7.2	-0.8	-2.7	-1.6
Medication: Ramipril	2.6	3.3	5.3	0.3	-2.3	-2.1
Birth weight	2.6	5.6	7.5	-1.7	-2.7	-2.5
Taking other prescription medications	2.5	3.9	6.5	-2.2	-0.5	-2.5
Fluid intelligence score	2.5	5.3	6.9	1.8	-2.6	-2.4
Blood Platelet Count	2.4	28.2	41.9	-2.7	6.0	6.5
Medication: Atenolol	2.4	3.0	7.5	-2.7	1.1	-0.5
Time employed in main current job	2.4	2.7	5.3	0.6	2.3	1.6
Medication: Paracetamol	2.4	3.9	7.4	-0.7	2.7	2.0
Gout (self-reported)	2.4	3.4	8.7	0.0	-1.2	-3.0
Hypothyroidism/myxoedema (self-reported)	2.4	4.7	9.2	-3.0	-0.6	-2.1
Mean time to correctly identify matches	2.4	4.5	8.2	1.3	2.9	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.8	4.7	1.7	0.9	2.2
Alzheimer’s Disease (in mother)	2.3	2.7	5.2	-1.5	-0.8	-2.3
Fed-up feelings	2.3	4.3	5.3	-2.3	-1.5	-2.3
Relative age voice broke	2.3	3.6	5.7	0.3	-2.4	-2.2
Happiness	2.3	2.7	4.9	0.3	-2.2	-1.8
Number of treatments/medications taken	2.2	3.9	5.0	-1.9	-1.8	-2.2
Qualifications: None of the above	2.2	4.6	8.7	-1.2	3.0	1.9
Medication: Blood pressure	2.2	3.9	6.6	-1.4	-1.8	-2.6
Handedness (chirality/laterality): Left-handed	2.2	2.7	3.9	2.0	-1.7	-1.1
Ever depressed for a whole week	2.2	2.7	6.6	-1.1	-0.6	-2.6
Basal cell carcinoma (self-reported)	2.2	2.6	3.9	-0.8	-1.8	-2.0
Intelligence (Savage-Jansen 2018)	2.1	6.3	9.5	0.5	-3.1	-3.0
Reaction Time	2.1	4.0	7.8	1.9	2.8	0.8
Angina (self-reported)	2.1	2.7	5.2	-2.3	-0.9	-1.5
Medication: Allopurinol	2.1	2.8	3.9	-0.8	-2.0	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	5.1	-1.2	2.3	0.9
Angina	2.0	2.6	5.2	-2.3	-1.0	-1.3
Nervous feelings	2.0	3.8	6.8	0.8	1.9	2.6
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.3	8.4	-0.4	-1.1	-2.9
Glaucoma (self-reported)	2.0	2.3	3.6	0.4	1.9	1.8
Hand grip strength (left)	1.9	5.1	8.9	-0.5	-3.0	-2.5
Birth weight of first child	1.9	3.4	7.6	-0.6	-2.8	-1.5
Number of children fathered	1.9	2.1	2.6	1.3	-1.4	-1.6
Health satisfaction	1.9	2.5	3.4	-1.9	1.3	-1.6
Qualifications: College or University degree	1.9	5.8	13.8	-0.5	-1.9	-3.7
Blood Eosinophil Count	1.8	13.8	27.6	0.5	3.7	5.2
Waist Hip Ratio (WHR)	1.8	8.1	18.8	-0.8	4.3	2.2
Qualifications: A levels/AS levels or equivalent	1.8	4.0	5.5	1.3	-2.2	-2.4
Age at last live birth	1.8	2.6	4.6	0.8	-1.6	-2.1
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	5.0	-1.0	0.8	-2.2
Severe depression (siblings)	1.7	1.9	2.5	-1.6	-1.4	-1.1
Ever had bowel cancer screening	1.7	2.0	3.7	-0.1	1.9	1.5
Ever taken oral contraceptive pill	1.7	1.9	4.6	-2.1	-0.4	-0.9
Worry (Nagel 2018)	1.6	3.3	5.6	2.1	0.2	2.4
Hypothyroidism (self reported)	1.6	3.6	7.7	-2.8	-0.0	-1.8
Chronotype (morning person)	1.6	3.6	10.0	-0.9	-3.2	-0.3
Medication: Co-codamol	1.6	1.8	4.4	-2.1	1.0	0.2
Hand grip strength (right)	1.6	4.4	6.3	-1.3	-2.3	-2.5
Pulse wave Arterial Stiffness index	1.6	1.9	2.5	-1.1	1.6	1.3
Pulse wave peak to peak time	1.6	1.8	2.7	1.0	-1.6	-1.3
Back pain experienced in last month	1.6	2.4	4.1	-1.0	1.4	2.0
Medication: Paracetamol	1.6	2.5	4.8	-1.0	2.2	1.3
Verbal and Numeric Reasoning (VNR)	1.5	3.7	6.3	1.4	-1.7	-2.5
Ever used hormone-replacement therapy (HRT)	1.5	1.8	4.5	0.8	0.7	2.1
Long-standing illness, disability or infirmity	1.5	2.2	3.1	-1.8	-0.8	-1.7
Diabetes (mother)	1.4	1.8	2.7	1.0	1.6	1.3
Supplements: Glucosamine	1.4	1.8	5.0	-0.6	-0.0	2.2
Illnesses of siblings	1.4	2.0	3.5	1.9	1.5	0.3
Father’s age at death	1.4	1.9	4.7	1.0	0.1	2.2
Number of live births	1.4	1.9	4.3	-0.7	2.1	1.0
Peak expiratory flow (PEF)	1.4	3.1	5.8	0.3	-2.4	-1.9
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	2.9	1.2	-1.7	-1.5
Shortness of breath walking on level ground	1.4	1.7	2.7	-1.5	-0.3	-1.6
Overall health rating	1.4	3.0	4.4	-1.9	2.1	-0.9
Eye problems/disorders: Glaucoma	1.4	1.7	2.9	-0.0	1.7	1.5
Hearing difficulty/problems: Yes	1.3	2.0	4.4	-0.2	-1.3	-2.1
Relative age of first facial hair	1.3	2.7	4.8	0.1	-1.8	-2.2
Chronic bronchitis/emphysema (father)	1.3	1.5	4.1	-0.7	2.0	0.2
High blood pressure (mother)	1.3	1.8	4.3	-0.4	2.1	0.9
Number of incorrect matches in round	1.3	2.1	4.8	-0.0	1.2	2.2
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	2.7	-0.5	-1.3	-1.6
Ever highly irritable/argumentative for 2 days	1.3	1.6	3.4	0.1	-1.1	-1.9
Medication: Ventolin 100micrograms inhaler	1.3	1.7	3.6	-0.2	1.1	1.9
Age at first live birth	1.3	2.4	4.3	0.8	-1.5	-2.1
Migraine (self-reported)	1.3	1.6	3.9	-2.0	-0.1	-0.9
Suffer from ‘nerves’	1.3	2.0	6.0	2.5	0.0	0.3
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	4.9	0.1	0.3	2.2
Bipolar Disorder (2011)	1.2	1.2	1.9	1.4	0.5	1.2
Type 2 Diabetes (T2D) (2018)	1.2	2.3	6.9	0.0	-0.0	-2.6
Alcohol usually taken with meals	1.2	1.9	4.9	2.2	-0.1	-0.9
Qualifications: nursing, teaching	1.2	1.9	4.9	0.8	0.1	-2.2
Eye problems/disorders: Cataract	1.2	1.4	3.3	-0.5	1.8	-0.8
Supplements: Fish oil (including cod liver oil)	1.2	1.6	3.8	-0.2	0.9	2.0
Supplements: Calcium	1.2	1.3	3.9	-2.0	-0.2	0.2
Forced vital capacity (FVC)	1.1	4.1	7.2	-1.5	-1.7	-2.7
Medication: Amlodipine	1.1	1.6	2.7	-0.1	-1.4	-1.6
Medication: Omeprazole	1.1	1.3	1.5	-1.1	-1.1	-1.2
Mineral and other dietary supplements	1.1	1.5	4.1	0.5	-0.5	-2.0
Heart attack/myocardial infarction (self-reported)	1.1	1.5	2.0	-1.0	-1.2	-1.4
Schizophrenia vs Biploar Disorder	1.0	1.3	2.5	-1.6	0.7	-0.9
Irritable Bowel Disease (IBD)	1.0	2.3	4.8	0.6	1.3	2.2
Breast Cancer	1.0	2.5	4.3	1.1	-2.1	-1.4
Ever had hysterectomy (womb removed)	1.0	1.2	2.1	0.9	0.7	1.4
Hair/balding pattern: Pattern 2	1.0	1.3	3.5	-0.6	0.2	-1.9
Heart attack	1.0	1.3	1.7	-1.1	-1.0	-1.3
Pain all over the body in last month	1.0	1.0	2.1	-0.9	-0.2	-1.5
Diabetes (self-reported)	1.0	1.5	3.7	-0.8	0.6	-1.9
Hair/balding pattern: Pattern 4	1.0	2.4	5.4	1.2	-2.3	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	1.5	1.2	0.8	1.2
Guilty feelings	1.0	1.5	2.5	0.0	-1.6	-1.4
Average weekly beer plus cider intake	1.0	1.4	3.1	-1.8	0.2	1.0
Vascular/heart problems diagnosed by doctor	1.0	2.6	6.6	2.6	0.8	0.8
Pain experienced in last month	1.0	1.7	2.6	1.6	-0.8	-1.3
Age at First Birth	0.9	1.3	3.4	1.8	-0.7	0.1
Ulcerative Colitis	0.9	1.4	1.5	1.1	1.2	1.2
Smoking Status	0.9	2.1	4.4	-0.6	2.1	1.2
Falls in the last year	0.9	1.2	3.4	-1.9	-0.3	0.1
Leg fat percentage (right)	0.9	3.2	5.8	-2.4	1.4	1.4
Exposure to tobacco smoke outside home	0.9	1.2	3.2	0.2	0.7	1.8
Wheeze or whistling in the chest in last year	0.9	1.6	2.6	-1.6	1.2	0.9
Neck or shoulder pain in last month	0.9	1.2	3.1	0.4	0.6	1.8
Family relationship satisfaction	0.9	1.1	2.7	-0.4	-0.7	-1.6
Medication: Lisinopril	0.9	1.2	3.0	-0.5	-1.7	-0.4
Alcohol drinker status: Previous	0.9	1.0	1.3	0.9	-1.2	-1.0
Lung FEV1/FVC ratio	0.8	4.0	6.5	1.5	1.8	2.5
Supplements: Zinc	0.8	0.9	1.5	1.2	0.7	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	1.9	1.4	0.2	-1.1
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.9	0.7	0.6	1.4
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	4.8	-1.0	-1.4	-2.2
Loud music exposure frequency	0.8	0.9	1.2	-0.8	-1.0	-1.1
Forced vital capacity (FVC), Best measure	0.8	3.0	5.5	-1.5	-1.1	-2.3
Body fat percentage	0.8	3.0	4.7	-2.2	1.2	1.7
Medication for pain relief, constipation, heartburn	0.8	1.3	3.7	0.4	-1.9	0.1
Pulse rate, automated reading	0.8	2.6	6.5	-1.1	2.5	0.1
Chest pain or discomfort	0.8	1.2	2.2	-1.5	1.0	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	2.9	-0.4	0.2	1.7
Knee pain experienced in last month	0.8	1.2	2.1	-1.4	1.2	0.2
Average weekly red wine intake	0.8	1.2	1.3	1.1	-1.1	-1.1
Mother’s age at death	0.8	1.0	1.6	1.2	1.2	0.0
Ever smoked	0.8	1.4	3.0	-1.1	0.2	1.7
Leg fat percentage (left)	0.8	2.9	4.7	-2.2	1.2	1.6
Ulcerative Colitis (UC)	0.7	1.4	2.7	0.5	1.1	1.6
Ovarian Cancer	0.7	0.9	1.5	0.4	-1.0	1.2
Systolic Blood Pressure	0.7	3.4	5.8	-0.1	-2.4	-2.1
Sensitivity / hurt feelings	0.7	1.1	2.1	0.5	-1.4	1.0
Townsend deprivation index at recruitment	0.7	1.0	2.2	-0.3	1.5	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.9	1.7	-0.3	1.3
Tense / ‘highly strung’	0.7	1.2	2.6	0.6	0.9	1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.8	0.4	-1.4	-0.6
Eye problems/disorders: None of the above	0.7	0.8	2.1	0.5	-1.4	0.2
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.6	-0.3	1.2	-0.9
Had major operations	0.7	0.8	1.6	-1.3	-0.1	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	1.6	-1.1	1.2	-0.7
Osteoporosis (self-reported)	0.7	0.9	2.2	-1.5	0.5	-0.4
Average weekly champagne plus white wine intake	0.7	1.0	2.4	0.7	-0.2	-1.6
Commuting to job workplace: Public transport	0.7	0.8	1.9	-1.4	-0.7	-0.2
Number of operations (self-reported)	0.7	1.0	2.1	-1.4	-0.5	-0.7
Bipolar Disorder (2018)	0.6	1.0	2.6	1.6	0.2	0.6
Prostate Cancer	0.6	0.9	2.1	0.1	-1.5	0.7
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.4	0.6	0.0	-1.2
Medication for hormone replacement therapy	0.6	0.7	1.0	1.0	-0.4	1.0
Trunk fat percentage	0.6	2.5	3.4	-1.9	0.9	1.8
Medication: Levothyroxine sodium	0.6	0.9	1.7	-1.3	0.3	-1.0
Mouth/teeth dental problems	0.6	0.9	1.1	1.0	-1.1	-0.8
Noisy workplace	0.6	0.7	1.7	-1.3	-0.5	-0.4
Depression (self-reported)	0.6	0.8	1.5	0.5	1.2	-0.8
Lung cancer (father)	0.6	0.7	1.8	-0.7	1.3	-0.0
Headache pain in last month	0.6	1.0	1.5	-0.8	0.9	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	2.8	-0.7	-0.5	-1.7
Diabetes diagnosed by doctor	0.6	0.9	1.8	-0.8	0.5	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.9	-0.2	-1.4	-0.3
Osteoarthritis (self-reported)	0.6	0.8	2.1	-1.4	0.4	-0.4
Wears glasses or contact lenses	0.6	0.7	1.4	0.1	0.9	1.2
Financial situation satisfaction	0.6	0.8	2.0	-0.4	-0.4	-1.4
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.9	0.2	-1.4	-0.2
Alcohol drinker status: Never	0.6	0.8	1.0	-1.0	0.8	0.8
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.0	1.0	-0.6	0.9
Depression (Nagel 2018)	0.5	0.8	1.7	1.3	0.2	-0.8
Lupus	0.5	0.7	1.1	-0.8	0.6	1.0
Neuroticism (2016)	0.5	0.8	1.2	-1.1	1.1	-0.2
Lung FVC	0.5	2.6	6.4	-0.5	-2.5	-1.1
Diabetes (father)	0.5	0.6	1.0	-0.0	1.0	-0.9
Average weekly fortified wine intake	0.5	0.5	0.9	0.6	0.6	0.9
Maternal smoking around birth	0.5	0.8	1.2	-0.2	1.1	1.0
High blood pressure	0.5	1.5	4.3	-2.1	-0.2	-0.4
Waist circumference	0.5	1.9	2.9	-1.6	1.7	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.9	2.2	-1.5	-0.6	-0.1
Trunk fat-free mass	0.5	3.0	6.9	-0.4	-1.4	-2.6
Hair/balding pattern: Pattern 3	0.5	0.8	1.6	0.1	1.3	0.9
Mouth/teeth dental problems: Dentures	0.5	0.8	1.8	-0.6	-0.1	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	3.2	-0.8	-0.8	-1.8
Impedance of arm (left)	0.5	2.2	3.6	0.6	1.9	1.6
Trunk predicted mass	0.5	2.9	6.6	-0.4	-1.4	-2.6
Breastfed as a baby	0.5	0.6	1.5	-0.0	0.5	1.2
Blood clot in the leg (DVT)	0.5	0.7	1.2	0.5	0.8	-1.1
Worry too long after embarrassment	0.5	0.8	1.5	1.2	-0.7	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.4	-1.2	0.3	-0.6
Supplements: Vitamin C	0.5	0.6	1.3	0.4	-0.7	1.2
Hypertension (Self-reported)	0.5	1.5	4.3	-2.1	-0.2	-0.1
Arm fat percentage (left)	0.5	1.9	2.5	-1.6	1.4	1.1
Mood swings	0.5	0.9	2.1	-0.3	-0.6	-1.4
Commuting to job workplace: Walk	0.5	0.5	1.1	-1.0	-0.7	0.3
Medication for cholesterol	0.5	0.8	1.8	0.5	1.3	0.6
Medication: Gliclazide	0.5	0.5	1.0	1.0	0.7	-0.2
Miserableness	0.5	0.9	1.7	-1.3	-0.1	-1.0
Risk taking	0.5	0.7	1.6	1.3	0.0	-0.7
Unable to work because of sickness or disability	0.5	0.7	1.7	0.1	1.3	0.7
Myopia	0.5	0.8	1.7	0.7	-1.3	0.4
Bipolar Disorder or Schizophrenia	0.4	1.0	1.4	1.2	1.1	0.4
Alzheimer’s Disease (in father)	0.4	0.5	0.8	0.8	-0.3	0.9
Major Depression (MDD)	0.4	0.5	1.0	1.0	0.1	-0.6
Primary Biliary Cirrhosis	0.4	0.6	1.7	-1.3	0.1	0.3
Rheumatoid Arthritis	0.4	0.5	1.0	-1.0	0.0	0.8
Heel T-Score	0.4	3.3	7.9	2.8	-1.1	0.9
Neuroticism	0.4	1.0	1.1	1.0	1.1	0.9
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.8	-0.1	-0.2	-1.3
Current tobacco smoking	0.4	0.7	1.3	0.6	1.2	0.5
Qualifications: CSEs or equivalent	0.4	0.6	1.2	-0.6	1.1	0.4
Serious illness, injury or assault to yourself	0.4	0.5	1.3	-0.4	1.1	0.2
Multivitamins +/- minerals	0.4	0.5	0.7	-0.4	-0.8	0.9
Past tobacco smoking	0.4	0.8	1.9	1.4	-0.2	-0.6
Hearing difficulty/problems with background noise	0.4	0.6	1.4	1.2	-0.5	-0.3
Had menopause	0.4	0.5	1.1	-1.1	0.5	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.6	0.7	-1.3	1.0
Impedance of arm (right)	0.4	1.9	3.3	0.8	1.4	1.8
Worrier / anxious feelings	0.4	0.8	1.4	0.5	-1.2	0.9
Length of working week for main job	0.4	0.5	1.2	-0.1	0.5	1.1
Pulse wave reflection index	0.4	0.5	1.6	-0.2	0.1	1.3
Leg fat mass (right)	0.4	1.5	4.2	-2.1	0.3	0.3
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.1	1.0	0.3	0.6
Whole body fat-free mass	0.4	2.4	4.9	-0.3	-1.5	-2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.4	-0.7	-1.2	-0.8
Whole body water mass	0.4	2.0	4.1	-0.3	-1.4	-2.0
Illnesses of father: High blood pressure	0.4	0.5	0.7	0.8	-0.9	-0.2
Arm fat-free mass (left)	0.4	2.3	3.0	-1.0	-1.7	-1.7
Commuting to job workplace: Cycle	0.4	0.5	0.6	-0.7	0.8	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	0.8	0.4	0.9	-0.8
Impedance of whole body	0.4	1.9	3.3	0.2	1.5	1.8
Arm predicted mass (left)	0.4	2.1	3.1	-0.8	-1.6	-1.8
Neuroticism (Nagel 2018)	0.3	0.6	1.0	1.0	-0.2	0.9
Schizophrenia (2018)	0.3	0.6	1.6	0.2	1.3	0.1
Crohns Disease (2017)	0.3	0.7	2.0	0.1	0.4	1.4
Body Mass Index (BMI) (2010)	0.3	0.4	0.6	-0.8	0.1	-0.7
Mean Putamen Volume	0.3	0.4	0.8	0.9	-0.6	-0.1
HbA1C	0.3	0.3	0.9	0.2	-0.0	0.9
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.5	0.2	-0.7	-0.7
Vitamin and mineral supplements	0.3	0.4	0.5	0.5	0.7	-0.7
Medication: Metformin	0.3	0.4	0.9	0.4	0.4	-0.9
Leg fat-free mass (left)	0.3	1.3	2.5	-0.4	-1.2	-1.6
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.8	-0.9	0.2	-0.2
Stomach or abdominal pain in last month	0.3	0.4	0.5	0.6	0.6	0.7
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.0	-1.0	-0.3	0.1
Sitting height	0.3	1.9	3.4	-0.3	-1.8	-1.5
Trunk fat mass	0.3	1.5	3.3	-1.8	0.5	1.0
Financial difficulties in last 2 years	0.3	0.5	0.9	-1.0	-0.5	-0.5
Arm fat percentage (right)	0.3	1.4	2.5	-1.6	0.9	0.9
Medication: Lansoprazole	0.3	0.3	0.5	0.7	0.3	0.6
Illnesses of mother	0.3	0.4	0.9	0.6	-0.3	0.9
Exposure to tobacco smoke at home	0.3	0.3	0.4	-0.6	-0.4	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.9	-0.9	0.2	-0.8
High blood pressure (siblings)	0.3	0.5	0.8	-0.9	-0.5	0.5
Arm fat-free mass (right)	0.3	1.7	2.7	-0.8	-1.4	-1.6
Medication: Ibuprofen	0.3	0.4	0.6	0.2	0.7	0.7
Whole body fat mass	0.3	1.4	3.2	-1.8	0.5	0.8
Arm predicted mass (right)	0.3	1.6	2.3	-0.7	-1.4	-1.5
Alcohol intake frequency.	0.3	0.6	0.9	-0.7	1.0	0.6
Smoking status: Previous	0.3	0.5	1.1	-1.0	0.0	0.5
Leg fat-free mass (right)	0.3	1.5	2.4	-0.0	-1.6	-1.5
Smoking status: Current	0.3	0.5	1.1	0.5	1.0	0.3
Leg predicted mass (right)	0.3	1.4	2.4	-0.0	-1.5	-1.4
Hearing aid user	0.3	0.3	0.7	0.2	0.5	0.8
Medication: Blood pressure	0.3	0.6	1.7	-0.1	0.1	1.3
Basal metabolic rate	0.3	1.7	3.3	-0.6	-1.3	-1.8
Fractured/broken bones in last 5 years	0.3	0.4	0.4	0.6	0.5	-0.6
Age started oral contraceptive pill	0.3	0.3	0.7	-0.0	-0.8	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.6	-0.8	-0.3	-0.6
Leg fat mass (left)	0.3	1.4	3.7	-1.9	0.3	0.5
Fasting Glucose	0.2	0.3	0.7	0.1	-0.9	0.3
Schizophrenia (2014)	0.2	0.5	1.6	0.1	1.3	0.0
Allergy or Eczema	0.2	0.5	0.9	-0.9	-0.6	0.4
Average weekly spirits intake	0.2	0.2	0.7	0.2	-0.1	-0.8
Pack years adult smoking proportion	0.2	0.3	0.8	0.9	0.1	0.3
Impedance of leg (right)	0.2	0.9	1.1	-0.9	1.1	0.9
Age when periods started (menarche)	0.2	0.5	1.1	0.0	-0.6	-1.0
Body mass index (BMI)	0.2	0.8	2.3	-1.5	0.2	0.2
Impedance of leg (left)	0.2	0.9	1.9	-0.4	0.8	1.4
Leg predicted mass (left)	0.2	1.3	2.3	-0.3	-1.2	-1.5
Had other major operations	0.2	0.3	0.5	-0.2	0.4	-0.7
Weight	0.2	0.9	2.3	-1.5	-0.3	-0.5
Alcohol intake versus 10 years previously	0.2	0.3	0.6	0.0	-0.8	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	0.4	0.4	0.7
Standing height	0.2	1.8	3.0	-0.2	-1.5	-1.7
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.3	0.5	-0.6	-0.4
Comparative body size at age 10	0.2	0.6	1.0	-0.7	-1.0	-0.4
Number of full sisters	0.2	0.2	0.3	0.4	0.5	0.3
Loneliness, isolation	0.2	0.3	0.4	0.6	0.6	-0.3
Arm fat mass (left)	0.2	0.9	2.2	-1.5	0.4	0.4
Irritability	0.2	0.3	0.5	-0.6	-0.7	0.1
Depressed Affect (Nagel 2018)	0.1	0.3	0.4	-0.1	0.7	-0.6
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	-0.0	-0.7	-0.5
Blood White Count	0.1	0.7	1.8	-0.0	1.4	0.5
BMI	0.1	0.6	1.0	-0.4	-0.8	-1.0
Height	0.1	1.3	3.7	-1.9	-0.4	-0.2
Respiratory disease	0.1	0.3	0.6	-0.8	-0.4	0.2
Hair Pigment	0.1	2.2	6.0	-0.8	2.4	0.2
Tanning	0.1	0.9	2.2	1.5	0.2	0.8
Systolic blood pressure, automated reading	0.1	0.4	1.0	-0.4	-1.0	-0.1
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	0.7	-0.4	0.0
Allergy	0.1	0.2	0.4	-0.6	-0.2	0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	-0.1	0.6	0.2
Hip circumference	0.1	0.5	1.2	-1.1	-0.2	-0.3
Asthma	0.1	0.2	0.4	0.5	0.1	0.7
Arm fat mass (right)	0.1	0.6	1.7	-1.3	0.2	0.1
Emphysema/chronic bronchitis	0.1	0.1	0.4	0.3	0.0	-0.6
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.3	0.5	0.3
Asthma (self-reported)	0.1	0.2	0.2	0.5	-0.5	0.3
Pack years of smoking	0.1	0.2	0.5	0.7	-0.2	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.1	-0.2	0.1
Blood Red Count	0.0	0.3	0.7	-0.8	0.3	0.1
Neuroticism score	0.0	0.1	0.1	0.4	-0.2	0.0
Mouth/teeth dental problems: Bleeding gums	0.0	0.1	0.1	0.2	0.3	0.2
Comparative height size at age 10	0.0	0.2	0.3	-0.6	-0.2	0.4
Medication: Bendroflumethiazide	0.0	0.0	0.0	-0.0	0.2	-0.1
Diastolic blood pressure, automated reading	0.0	0.0	0.1	0.0	-0.3	-0.1

Hub : Genes

BUD13

Models

Trait associations