Best TWAS P=7.08e-23 · Best GWAS P=2.25e-22 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FADS1 | 0.14 | 0.16 | lasso | 2 | 0.16 | 7.2e-19 | -9.7 | 9.7 | 2.0e-22 | -0.97 | 0.01 | 0.99 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | FEN1 | 0.07 | 0.06 | lasso | 4 | 0.06 | 1.1e-07 | -9.7 | -9.8 | 7.1e-23 | 0.97 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Artery Aorta | FADS2 | 0.18 | 0.17 | lasso | 3 | 0.14 | 3.2e-08 | -3.9 | -5.3 | 1.1e-07 | 0.69 | 0.34 | 0.65 | FALSE |
| 4 | GTEx | Artery Tibial | FADS2 | 0.08 | 0.02 | lasso | 4 | 0.02 | 6.9e-03 | -8.8 | -6.4 | 2.0e-10 | 0.79 | 0.02 | 0.96 | FALSE |
| 5 | GTEx | Artery Tibial | TMEM258 | 0.08 | 0.05 | lasso | 5 | 0.02 | 1.1e-02 | -9.8 | -9.8 | 1.4e-22 | 0.98 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Brain Cerebellum | FADS1 | 0.35 | 0.24 | enet | 16 | 0.30 | 2.1e-09 | -9.2 | 9.7 | 3.9e-22 | -0.91 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Brain Cerebellum | FADS3 | 0.26 | 0.18 | lasso | 4 | 0.14 | 5.7e-05 | -9.3 | 9.6 | 1.0e-21 | -0.93 | 0.02 | 0.89 | FALSE |
| 8 | GTEx | Brain Putamen basal ganglia | FADS1 | 0.29 | 0.21 | enet | 30 | 0.16 | 1.4e-04 | -9.7 | 7.9 | 3.7e-15 | -0.76 | 0.02 | 0.92 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Female) | TMEM258 | 0.20 | 0.02 | lasso | 7 | 0.00 | 2.3e-01 | -7.7 | -8.2 | 1.9e-16 | 0.78 | 0.03 | 0.57 | FALSE |
| 10 | GTEx | Cells Transformed fibroblasts | TMEM258 | 0.15 | 0.05 | enet | 15 | 0.07 | 1.1e-05 | -8.8 | -8.1 | 6.7e-16 | 0.78 | 0.05 | 0.94 | FALSE |
| 11 | GTEx | Colon Transverse | FADS2 | 0.18 | 0.11 | lasso | 7 | 0.16 | 8.1e-08 | -3.9 | -6.9 | 7.0e-12 | 0.75 | 0.07 | 0.93 | FALSE |
| 12 | GTEx | Esophagus Mucosa | FADS1 | 0.11 | 0.00 | lasso | 4 | 0.02 | 1.9e-02 | -9.4 | 8.4 | 3.7e-17 | -0.85 | 0.03 | 0.91 | FALSE |
| 13 | GTEx | Esophagus Muscularis | FADS2 | 0.32 | 0.30 | lasso | 6 | 0.31 | 3.7e-19 | -3.9 | -5.6 | 2.2e-08 | 0.71 | 1.00 | 0.00 | FALSE |
| 14 | GTEx | Heart Left Ventricle | FADS2 | 0.17 | 0.12 | enet | 3 | 0.13 | 1.5e-07 | -4.9 | -5.4 | 5.7e-08 | 0.71 | 0.19 | 0.80 | FALSE |
| 15 | GTEx | Muscle Skeletal | FADS2 | 0.08 | 0.04 | lasso | 2 | 0.03 | 5.9e-04 | -9.7 | -8.4 | 4.2e-17 | 0.91 | 0.02 | 0.98 | FALSE |
| 16 | GTEx | Pancreas | FADS1 | 0.17 | 0.13 | lasso | 6 | 0.12 | 1.2e-05 | -9.3 | 9.5 | 1.4e-21 | -0.92 | 0.04 | 0.96 | FALSE |
| 17 | GTEx | Spleen | FADS2 | 0.30 | 0.27 | lasso | 3 | 0.27 | 1.6e-07 | -3.9 | -5.5 | 3.1e-08 | 0.72 | 0.10 | 0.89 | FALSE |
| 18 | GTEx | Uterus | PPP1R32 | 0.66 | -0.01 | lasso | 13 | 0.14 | 8.8e-04 | -1.2 | -5.7 | 1.1e-08 | 0.59 | 0.03 | 0.44 | FALSE |
| 19 | METSIM | Adipose | TMEM258 | 0.04 | 0.00 | bslmm | 407 | 0.01 | 4.1e-02 | -9.3 | -8.1 | 3.9e-16 | 0.64 | 0.02 | 0.89 | FALSE |
| 20 | NTR | Blood | C11orf10 | 0.06 | 0.08 | bslmm | 399 | 0.08 | 1.3e-24 | -8.8 | -9.1 | 9.2e-20 | 0.91 | 0.06 | 0.94 | FALSE |
| 21 | ROSMAP | Brain Pre-frontal Cortex | TMEM258 | 0.14 | 0.16 | lasso | 4 | 0.15 | 4.7e-19 | -8.8 | -9.2 | 5.1e-20 | 0.93 | 0.06 | 0.94 | FALSE |
| 22 | ROSMAP | Brain Pre-frontal Cortex | FADS1 | 0.08 | 0.08 | enet | 10 | 0.09 | 1.5e-11 | -9.7 | 9.6 | 8.6e-22 | -0.96 | 0.01 | 0.99 | FALSE |
| 23 | YFS | Blood | FADS1 | 0.11 | 0.08 | lasso | 8 | 0.09 | 6.1e-29 | -3.9 | -6.6 | 5.3e-11 | 0.77 | 1.00 | 0.00 | FALSE |
| 24 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FADS1 | 0.04 | 0.00 | blup | 53 | 0.01 | 1.4e-03 | -2.7 | 6.8 | 8.1e-12 | -0.62 | 0.02 | 0.39 | FALSE |
| 25 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FADS1 | 0.06 | 0.03 | lasso | 4 | 0.04 | 7.4e-03 | -9.3 | 8.8 | 1.0e-18 | -0.82 | 0.02 | 0.70 | FALSE |
| 26 | The Cancer Genome Atlas | Colon Adenocarcinoma | FADS2 | 0.30 | 0.21 | lasso | 2 | 0.22 | 6.7e-13 | -3.9 | -6.0 | 1.5e-09 | 0.76 | 0.64 | 0.36 | FALSE |
| 27 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FADS2 | 0.05 | 0.04 | lasso | 3 | 0.05 | 1.9e-06 | -3.9 | -6.3 | 3.5e-10 | 0.71 | 0.21 | 0.74 | FALSE |
| 28 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FADS2 | 0.26 | 0.29 | enet | 15 | 0.29 | 2.9e-33 | -3.9 | -6.1 | 8.4e-10 | 0.73 | 1.00 | 0.00 | FALSE |
| 29 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FADS2 | 0.33 | 0.27 | lasso | 9 | 0.35 | 9.3e-21 | -3.9 | -6.1 | 1.0e-09 | 0.78 | 0.54 | 0.46 | FALSE |
| 30 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FADS1 | 0.05 | 0.05 | blup | 53 | 0.04 | 6.8e-05 | -7.7 | 8.1 | 5.1e-16 | -0.86 | 0.04 | 0.96 | FALSE |
| 31 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | FADS1 | 0.20 | 0.01 | blup | 51 | 0.07 | 3.2e-04 | -9.8 | 9.3 | 1.6e-20 | -0.85 | 0.01 | 0.95 | FALSE |
| 32 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FADS2 | 0.02 | 0.01 | blup | 71 | 0.02 | 1.9e-03 | -9.7 | -9.7 | 4.9e-22 | 0.91 | 0.02 | 0.82 | FALSE |
| 33 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C11orf10 | 0.02 | 0.01 | enet | 11 | 0.01 | 1.6e-02 | -8.8 | -5.5 | 4.2e-08 | 0.78 | 0.01 | 0.78 | TRUE |
| 34 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FADS1 | 0.06 | 0.04 | blup | 53 | 0.03 | 2.0e-04 | -9.2 | 7.0 | 3.5e-12 | -0.68 | 0.07 | 0.52 | FALSE |
| 35 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FADS2 | 0.07 | 0.07 | lasso | 4 | 0.06 | 1.9e-06 | -3.9 | -5.2 | 2.3e-07 | 0.70 | 0.14 | 0.84 | FALSE |
| 36 | The Cancer Genome Atlas | Rectum Adenocarcinoma | FADS2 | 0.47 | 0.34 | lasso | 5 | 0.30 | 7.9e-08 | -3.9 | -5.2 | 1.6e-07 | 0.69 | 0.04 | 0.95 | FALSE |
| 37 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FADS2 | 0.15 | 0.05 | blup | 71 | 0.11 | 2.5e-08 | -3.9 | -7.0 | 2.1e-12 | 0.72 | 0.04 | 0.96 | FALSE |
| 38 | The Cancer Genome Atlas | Thyroid Carcinoma | C11orf10 | 0.02 | 0.02 | blup | 44 | 0.02 | 1.8e-03 | -8.3 | -9.0 | 3.1e-19 | 0.95 | 0.02 | 0.72 | FALSE |
| 39 | The Cancer Genome Atlas | Thyroid Carcinoma | FADS2 | 0.30 | 0.33 | lasso | 8 | 0.33 | 5.6e-33 | -3.9 | -5.5 | 3.7e-08 | 0.72 | 1.00 | 0.00 | FALSE |