Best TWAS P=0 · Best GWAS P=2.06e-306 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CIAPIN1 | 0.09 | 0.00 | blup | 590 | 0.02 | 1.3e-03 | -0.31 | 5.2 | 1.6e-07 | 0.07 | 0.29 | 0.02 | FALSE |
| 2 | GTEx | Adrenal Gland | PLLP | 0.32 | 0.01 | enet | 36 | 0.13 | 1.9e-05 | -11.50 | -8.2 | 2.7e-16 | -0.15 | 0.15 | 0.18 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | NLRC5 | 0.38 | 0.24 | lasso | 4 | 0.30 | 5.0e-23 | 38.90 | -36.5 | 4.8e-292 | -0.83 | 0.00 | 1.00 | TRUE |
| 4 | GTEx | Esophagus Mucosa | OGFOD1 | 0.15 | 0.00 | enet | 17 | 0.01 | 7.0e-02 | 0.76 | 10.0 | 1.7e-23 | 0.07 | 0.15 | 0.08 | FALSE |
| 5 | GTEx | Nerve Tibial | OGFOD1 | 0.10 | 0.01 | enet | 21 | 0.02 | 1.3e-02 | 0.82 | 5.4 | 6.0e-08 | 0.06 | 0.70 | 0.02 | TRUE |
| 6 | GTEx | Thyroid | MT1L | 0.17 | 0.02 | lasso | 4 | 0.04 | 4.1e-04 | -1.35 | -8.5 | 1.8e-17 | -0.20 | 0.06 | 0.04 | TRUE |
| 7 | METSIM | Adipose | HERPUD1 | 0.06 | 0.05 | lasso | 5 | 0.04 | 1.9e-06 | -6.25 | -13.9 | 5.9e-44 | -0.41 | 0.84 | 0.13 | FALSE |
| 8 | METSIM | Adipose | MT1E | 0.18 | 0.07 | enet | 27 | 0.13 | 6.3e-19 | -0.16 | 5.6 | 1.8e-08 | 0.19 | 1.00 | 0.00 | FALSE |
| 9 | METSIM | Adipose | NLRC5 | 0.07 | 0.01 | bslmm | 570 | 0.03 | 7.4e-05 | 2.90 | -12.7 | 5.9e-37 | -0.20 | 0.39 | 0.02 | TRUE |
| 10 | NTR | Blood | HERPUD1 | 0.02 | 0.00 | blup | 520 | 0.01 | 4.7e-04 | 9.46 | -12.7 | 1.1e-36 | -0.18 | 0.07 | 0.07 | FALSE |
| 11 | NTR | Blood | NLRC5 | 0.05 | 0.03 | lasso | 3 | 0.03 | 5.1e-09 | -6.57 | -7.2 | 7.2e-13 | -0.04 | 1.00 | 0.00 | TRUE |
| 12 | YFS | Blood | HERPUD1 | 0.10 | 0.06 | blup | 518 | 0.09 | 1.3e-26 | -1.53 | -12.2 | 3.1e-34 | -0.17 | 1.00 | 0.00 | FALSE |
| 13 | YFS | Blood | NLRC5 | 0.22 | 0.07 | bslmm | 564 | 0.17 | 9.0e-52 | -6.57 | -8.5 | 2.2e-17 | -0.05 | 1.00 | 0.00 | FALSE |
| 14 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | NLRC5 | 0.25 | 0.03 | enet | 12 | 0.06 | 6.1e-04 | 4.11 | -8.1 | 4.1e-16 | -0.13 | 0.02 | 0.04 | TRUE |
| 15 | The Cancer Genome Atlas | Colon Adenocarcinoma | CETP | 0.11 | 0.03 | blup | 90 | 0.05 | 1.2e-03 | -6.57 | -22.6 | 5.0e-113 | -0.41 | 0.02 | 0.57 | FALSE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HERPUD1 | 0.03 | 0.02 | blup | 80 | 0.02 | 5.2e-03 | -6.81 | -22.8 | 3.2e-115 | -0.69 | 0.02 | 0.29 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CETP | 0.05 | 0.03 | enet | 10 | 0.03 | 2.7e-04 | 37.40 | -30.5 | 7.3e-205 | -0.81 | 0.00 | 0.99 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CETP | 0.21 | 0.19 | lasso | 3 | 0.18 | 2.6e-10 | 39.40 | -41.2 | 0.0e+00 | -0.85 | 0.00 | 1.00 | TRUE |
| 19 | The Cancer Genome Atlas | Lung Adenocarcinoma | CETP | 0.06 | 0.04 | lasso | 1 | 0.04 | 2.8e-05 | 38.60 | -38.6 | 0.0e+00 | -0.66 | 0.05 | 0.90 | FALSE |
| 20 | The Cancer Genome Atlas | Lung Adenocarcinoma | NUP93 | 0.03 | 0.00 | blup | 79 | 0.01 | 1.9e-02 | -14.10 | 9.2 | 2.4e-20 | 0.10 | 0.00 | 0.90 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CETP | 0.07 | 0.08 | lasso | 1 | 0.07 | 7.8e-08 | 38.60 | -38.6 | 0.0e+00 | -0.66 | 0.18 | 0.82 | FALSE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SLC12A3 | 0.04 | 0.00 | blup | 84 | 0.02 | 8.6e-03 | -8.39 | -12.3 | 1.1e-34 | -0.15 | 0.09 | 0.04 | TRUE |
| 23 | The Cancer Genome Atlas | Soft Tissue Sarcoma | NLRC5 | 0.11 | 0.03 | blup | 141 | 0.04 | 2.0e-03 | -4.04 | -7.7 | 1.8e-14 | -0.17 | 0.05 | 0.05 | TRUE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | HERPUD1 | 0.06 | 0.02 | blup | 80 | 0.05 | 2.8e-05 | -13.10 | -27.5 | 1.0e-166 | -0.64 | 0.08 | 0.55 | FALSE |