Hub : Genes

NUP93

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2100 0.0370 2.7e-12 0.167 0.111 0.144 0.146 0.160 7.2e-20 2.1e-13 3.4e-17 2.1e-17 4.6e-19
2 GTEx Skin Not Sun Exposed Suprapubic 0.1690 0.0560 2.6e-03 0.109 NA 0.018 NA 0.080 1.4e-06 NA 3.4e-02 NA 3.6e-05
3 GTEx Skin Sun Exposed Lower leg 0.1450 0.0470 1.3e-03 0.064 NA 0.041 NA 0.048 5.1e-06 NA 2.4e-04 NA 7.2e-05
4 GTEx Vagina 0.6070 0.1420 6.8e-03 -0.012 NA -0.009 NA -0.010 7.7e-01 NA 6.0e-01 NA 6.4e-01
5 METSIM Adipose 0.0665 0.0262 2.1e-03 0.003 0.014 0.016 0.015 0.006 9.6e-02 2.9e-03 1.6e-03 2.2e-03 3.5e-02
6 YFS Blood 0.0275 0.0100 8.7e-04 0.024 0.008 0.017 0.015 0.018 1.6e-08 7.2e-04 1.6e-06 8.1e-06 1.2e-06
7 TCGA Lung Adenocarcinoma 0.0315 0.0167 3.6e-03 -0.002 0.010 -0.001 NA 0.000 6.5e-01 1.9e-02 4.6e-01 NA 3.6e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.4 0.6 2.0 -0.1 1.4 1.4 0.0 0.4 0.2 0.7
Bipolar Disorder or Schizophrenia 0.1 0.3 0.8 -0.8 0.3 0.6 0.0 0.9 -0.5 0.5
Depressed Affect (Nagel 2018) 0.3 0.7 4.6 -0.1 0.3 0.2 0.0 0.2 0.4 -2.1
Depression (Nagel 2018) 0.2 0.2 0.8 -0.2 0.3 -0.1 0.0 -0.9 0.5 -0.6
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.4 1.1 -1.2 -1.1 0.0 0.2 -0.1 -0.9
Neuroticism (Nagel 2018) 0.5 1.1 6.5 0.2 0.4 0.3 0.0 -0.4 0.9 -2.5
Schizophrenia (2018) 0.2 0.4 0.9 -1.0 -0.7 -0.4 0.0 0.9 -0.8 0.1
Schizophrenia vs Biploar Disorder 0.6 0.7 1.8 -1.0 1.1 1.3 0.0 0.4 -0.8 0.6
Worry (Nagel 2018) 0.7 1.4 4.3 1.1 -0.4 -0.5 0.0 -0.7 1.9 -2.1
Alzheimer’s Disease (in mother) 0.1 0.1 0.3 0.6 -0.3 -0.2 0.0 0.5 0.0 0.5
Alzheimer’s Disease (in father) 1.1 1.2 3.8 1.0 2.0 1.7 0.0 0.7 0.6 -0.0
Alzheimer’s Disease (including proxy) 0.1 0.2 0.8 0.9 0.3 0.2 0.0 -0.1 0.4 0.4
Crohns Disease (2017) 0.3 0.7 3.0 0.6 -0.3 -0.4 0.0 1.7 -0.1 -1.2
Irritable Bowel Disease (IBD) 0.4 1.0 3.7 0.9 0.3 0.3 0.0 1.9 -0.0 -1.6
Ulcerative Colitis (UC) 0.4 0.7 1.6 0.1 1.1 1.3 0.0 0.9 -0.6 -1.1
Major Depression (MDD) 0.2 0.3 0.9 -0.0 1.0 0.8 0.0 0.1 0.5 0.1
Reaction Time 1.5 2.8 7.1 2.0 -0.1 -0.2 0.0 2.3 2.7 1.9
Verbal and Numeric Reasoning (VNR) 0.2 0.6 2.5 -0.1 0.6 0.4 0.0 0.3 -1.6 -0.8
Breast Cancer 0.8 2.0 9.2 0.6 -1.3 -1.4 0.0 -3.0 0.8 0.1
Ovarian Cancer 0.5 0.7 2.1 0.1 -1.2 -1.4 0.0 0.3 -0.2 -1.0
Prostate Cancer 0.5 0.6 4.2 0.5 0.0 -0.3 0.0 0.1 -0.1 -2.0
Age at First Birth 1.7 2.5 5.5 2.3 -1.1 -1.2 0.0 -1.9 2.3 0.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1
Body Mass Index (BMI) (2010) 0.5 0.7 1.9 -1.0 0.8 1.0 0.0 0.0 -1.4 0.3
Coronary Artery Disease (CAD) 0.1 0.1 0.4 -0.6 0.2 0.0 0.0 0.3 0.3 -0.6
Crohns Disease (2012) 1.6 2.5 4.9 1.9 -1.9 -2.2 0.0 0.8 1.3 -1.8
Mean Putamen Volume 0.8 0.9 2.2 -1.5 -0.5 0.1 0.0 0.4 -1.5 -1.2
Fasting Glucose 1.3 1.6 3.1 -1.4 1.6 1.8 0.0 0.8 -1.4 0.8
HbA1C 2.2 2.4 6.0 -1.4 2.3 2.5 0.0 0.0 -1.1 1.5
HDL Cholesterol 8.1 13.5 85.4 1.0 -0.2 0.1 0.0 -2.5 -1.5 9.2
LDL Cholesterol 0.6 1.0 2.0 -1.2 1.1 1.0 0.0 0.2 -1.0 -1.4
Lupus 0.4 0.7 2.6 0.5 -0.7 -0.6 0.0 1.6 0.9 -0.5
Neuroticism (2016) 0.2 0.3 0.5 -0.5 -0.6 -0.5 0.0 -0.3 -0.7 -0.6
Primary Biliary Cirrhosis 0.5 0.7 2.1 -0.6 1.4 1.4 0.0 0.6 -0.1 0.7
Rheumatoid Arthritis 0.8 1.1 2.7 -1.2 -1.1 -1.2 0.0 0.9 -1.6 -0.5
Schizophrenia (2014) 0.2 0.5 1.7 0.6 -0.9 -0.5 0.0 1.3 0.5 0.6
Triglycerides 0.8 1.3 6.5 -0.8 -0.2 -0.3 0.0 1.3 -0.1 -2.6
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.8 0.9 -0.7 -0.7 0.0 -0.1 0.1 0.1
Ulcerative Colitis 0.3 0.5 1.5 1.2 0.6 0.4 0.0 1.0 0.4 -0.2
Blood Eosinophil Count 0.3 2.1 7.7 0.1 0.5 0.4 0.0 2.8 2.6 0.4
Blood Platelet Count 0.1 0.9 5.6 0.2 -0.3 -0.5 0.0 -2.4 -0.3 0.3
Blood Red Count 0.0 0.2 0.7 0.4 -0.4 -0.8 0.0 -0.4 0.2 -0.6
Blood White Count 0.3 2.5 3.9 1.9 -1.7 -2.0 0.0 1.9 1.7 -0.2
Heel T-Score 0.3 2.2 10.6 0.7 1.2 1.3 0.0 -3.3 0.2 1.1
BMI 0.2 1.4 5.3 -1.6 0.6 0.6 0.0 2.3 -0.3 1.0
Height 0.2 3.2 8.8 -0.1 -2.4 -2.2 0.0 -1.7 -0.3 -3.0
Waist Hip Ratio (WHR) 0.1 0.3 0.6 0.1 -0.6 -0.8 0.0 -0.4 0.5 -0.7
Systolic Blood Pressure 0.5 2.6 11.8 -3.4 0.0 0.3 0.0 0.3 -2.2 -1.1
Smoking Status 0.3 0.7 1.4 0.6 -1.1 -1.2 0.0 -0.1 1.1 -0.9
Allergy or Eczema 0.1 0.2 0.4 -0.6 0.4 0.5 0.0 -0.2 0.4 0.6
Cardiovascular Disease 0.7 2.3 6.5 -2.5 1.3 1.3 0.0 2.4 -0.5 -0.3
Hypothyroidism (self reported) 0.3 0.7 1.7 -0.4 -0.8 -0.5 0.0 0.3 1.3 -1.3
Respiratory disease 0.9 2.0 6.2 -0.4 -1.5 -1.6 0.0 -1.6 -0.4 -2.5
Type 2 Diabetes (T2D) (2018) 0.6 1.1 5.9 0.7 0.4 0.2 0.0 2.4 -0.0 1.0
Lung FEV1/FVC ratio 0.3 1.6 5.9 1.7 -0.5 -0.9 0.0 0.7 2.4 -0.7
Lung FVC 0.2 0.9 2.3 -1.5 0.1 0.4 0.0 -0.8 -1.5 1.0
Neuroticism 0.4 1.0 3.6 0.7 -0.4 -0.4 0.0 -0.8 1.9 -1.3
Chronotype (morning person) 0.3 0.7 2.4 0.6 0.2 0.4 0.0 -1.6 1.4 0.2
Hair Pigment 0.0 0.3 0.7 0.8 0.5 0.3 0.0 0.5 -0.6 -0.8
Tanning 0.1 1.4 5.2 -2.3 1.1 1.4 0.0 -0.1 -1.0 0.8
Hand grip strength (left) 0.8 2.2 6.8 -0.4 -2.1 -1.8 0.0 -1.0 -0.4 -2.6
Number of treatments/medications taken 0.8 1.4 3.0 -0.6 1.7 1.2 0.0 1.7 0.6 -1.4
Average weekly spirits intake 0.6 0.8 2.3 1.4 -0.0 -0.0 0.0 0.4 1.5 -1.0
Sensitivity / hurt feelings 0.7 1.2 3.2 0.3 -1.7 -1.8 0.0 -0.5 -0.0 -1.3
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.0 0.0 -0.8 -1.0 0.0 -0.9 0.2 -1.0
Hearing difficulty/problems: Yes 0.5 0.7 3.5 0.1 0.3 0.3 0.0 1.9 0.1 -1.1
Relative age of first facial hair 0.2 0.4 2.0 0.3 0.1 0.2 0.0 -0.9 -0.1 1.4
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 6.4 0.2 -1.2 -1.3 0.0 2.5 0.2 -0.0
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.7 0.4 0.8 0.5 0.0 -0.2 1.3 1.0
Ever had hysterectomy (womb removed) 0.9 1.0 2.6 -0.8 1.2 1.1 0.0 -1.6 -0.4 1.1
Systolic blood pressure, automated reading 0.3 1.0 3.7 -1.9 0.7 0.8 0.0 -0.3 -1.1 -0.9
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 1.4 -1.2 0.7 0.8 0.0 1.0 -0.2 0.5
Angina 0.6 0.8 2.1 -0.6 -0.1 -0.1 0.0 1.5 -0.9 -1.4
Medication for hormone replacement therapy 0.2 0.3 1.6 0.0 -0.5 -0.2 0.0 -1.3 0.0 0.3
Vitamin and mineral supplements 2.3 3.1 10.6 -3.3 1.4 1.6 0.0 1.0 -2.4 0.0
Supplements: Zinc 1.3 1.4 3.9 1.6 -1.1 -1.3 0.0 0.5 2.0 -0.5
Medication: Co-codamol 0.5 0.6 3.2 0.7 -0.1 -0.2 0.0 -1.8 0.4 -0.4
Medication: Metformin 0.6 0.8 1.6 1.3 -1.0 -1.2 0.0 1.2 0.2 -0.1
Diabetes (father) 0.6 0.8 4.9 -0.2 -0.1 -0.2 0.0 2.2 0.4 -0.4
Diabetes (mother) 0.8 1.1 3.7 0.6 0.5 0.4 0.0 -1.6 0.7 1.9
Severe depression (siblings) 0.8 0.9 3.7 -1.9 0.1 0.3 0.0 -1.4 -0.4 -0.8
Pack years adult smoking proportion 0.8 1.3 5.3 1.1 -1.0 -0.9 0.0 -0.4 0.8 2.3
Impedance of leg (right) 0.2 1.0 5.5 0.7 -0.7 -0.8 0.0 -2.4 -0.1 -0.2
Leg fat-free mass (left) 0.2 0.9 5.7 -0.3 -0.1 0.1 0.0 2.4 0.6 0.5
Trunk fat percentage 0.0 0.1 0.8 -0.2 0.3 0.1 0.0 0.9 0.2 -0.1
Hand grip strength (right) 0.7 1.8 6.7 -0.5 -1.6 -1.3 0.0 -0.3 -1.1 -2.6
Townsend deprivation index at recruitment 0.5 0.7 1.8 -1.4 -0.8 -0.7 0.0 -1.3 0.0 -0.5
Current tobacco smoking 0.3 0.4 2.1 -1.4 -0.1 0.0 0.0 0.5 -0.8 0.1
Average weekly fortified wine intake 0.5 0.6 1.2 0.9 0.8 0.6 0.0 0.2 1.1 1.1
Maternal smoking around birth 1.7 2.4 6.0 0.1 -2.2 -2.3 0.0 2.5 0.7 -0.7
Fed-up feelings 0.3 0.5 1.9 0.1 -0.6 -0.6 0.0 0.8 0.4 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.6 0.4 -0.5 -0.6 0.0 0.3 0.8 -0.6
Relative age voice broke 0.1 0.1 0.3 0.6 -0.1 -0.1 0.0 -0.4 0.5 0.1
Taking other prescription medications 1.2 1.9 6.0 0.5 -0.9 -1.3 0.0 1.9 1.0 -2.5
Age when periods started (menarche) 1.5 3.6 9.2 -1.3 2.9 3.0 0.0 -1.0 -1.3 1.7
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 1.5 -0.2 0.8 0.7 0.0 -1.2 0.3 0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.5 7.6 0.8 -0.9 -0.9 0.0 -2.8 0.9 -0.5
Tinnitus: Yes, but not now, but have in the past 2.4 2.6 5.0 -2.2 2.0 1.9 0.0 -1.4 -1.9 0.3
Qualifications: CSEs or equivalent 1.0 1.3 3.5 0.6 -1.9 -1.8 0.0 -0.2 0.5 -1.3
Serious illness, injury or assault to yourself 2.5 3.1 5.9 2.4 -1.7 -1.8 0.0 1.6 2.4 -1.2
High blood pressure 0.4 1.2 2.7 -1.5 0.8 1.0 0.0 1.6 -0.4 -1.2
Hayfever, allergic rhinitis or eczema 0.2 0.5 0.9 -1.0 0.9 0.9 0.0 0.2 -0.1 0.9
Multivitamins +/- minerals 0.7 0.9 3.9 2.0 -0.5 -0.6 0.0 -0.8 0.9 -0.6
Stomach or abdominal pain in last month 0.7 0.8 1.7 1.2 -1.3 -1.1 0.0 1.0 0.6 -0.4
Supplements: Glucosamine 0.2 0.3 1.0 0.1 -0.9 -1.0 0.0 0.5 0.1 -0.1
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 3.4 -1.8 -0.0 0.2 0.0 -1.1 -1.6 0.0
Medication: Atenolol 1.7 2.2 6.9 1.3 -0.9 -1.3 0.0 2.0 2.6 -0.3
Medication: Levothyroxine sodium 0.4 0.7 2.1 0.6 0.3 0.2 0.0 1.3 1.5 -0.9
Sitting height 0.1 0.4 1.5 0.2 -0.9 -0.7 0.0 0.4 -0.2 -1.2
Chronic bronchitis/emphysema (father) 0.4 0.5 1.3 -0.6 0.4 0.5 0.0 1.1 -0.4 1.2
High blood pressure (mother) 2.6 3.6 7.0 -2.0 2.4 2.6 0.0 2.2 -0.6 1.7
Body mass index (BMI) 0.3 1.1 5.4 -0.8 0.8 0.7 0.0 2.3 0.3 0.5
Impedance of leg (left) 0.2 1.1 4.7 0.9 -1.0 -1.1 0.0 -2.2 -0.0 -0.2
Leg predicted mass (left) 0.2 0.9 5.3 -0.4 -0.1 0.1 0.0 2.3 0.6 0.5
Trunk fat mass 0.1 0.3 2.0 -0.2 0.3 0.2 0.0 1.4 0.1 0.1
Waist circumference 0.2 0.7 3.8 0.1 0.0 -0.0 0.0 1.9 0.9 0.6
Number of incorrect matches in round 0.3 0.5 1.2 0.3 -0.6 -1.0 0.0 1.1 0.3 -0.9
Past tobacco smoking 1.7 3.0 6.7 -2.3 1.6 1.8 0.0 -1.1 -2.6 1.5
Alcohol usually taken with meals 0.6 1.0 2.7 0.4 1.6 1.6 0.0 0.2 -0.7 1.1
Nervous feelings 0.3 0.6 2.8 0.5 -0.3 -0.4 0.0 -0.3 0.8 -1.7
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 2.7 -1.6 1.2 1.0 0.0 0.5 -1.1 -0.3
Hearing difficulty/problems with background noise 0.7 1.1 3.2 1.8 0.6 0.2 0.0 1.3 0.7 -1.3
Hair/balding pattern: Pattern 2 0.1 0.1 0.3 -0.1 0.1 0.1 0.0 0.6 -0.5 -0.3
Had menopause 0.4 0.5 1.3 -0.0 -0.7 -0.8 0.0 -1.1 -0.5 -0.9
Had other major operations 0.9 1.1 2.6 -1.6 0.9 1.2 0.0 -0.2 0.1 1.6
Forced vital capacity (FVC) 0.1 0.5 2.8 0.2 -0.4 -0.1 0.0 -0.6 0.1 1.7
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 5.9 1.1 -0.2 -0.5 0.0 -2.4 0.9 -0.0
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.8 -0.0 -0.2 -0.2 0.0 0.8 0.6 -1.4
Qualifications: None of the above 0.5 1.0 2.6 -0.4 -1.4 -1.4 0.0 1.6 0.1 -0.5
Financial difficulties in last 2 years 1.1 1.5 5.1 1.9 -0.9 -0.9 0.0 -0.8 2.3 0.2
Mouth/teeth dental problems 1.5 2.3 8.2 1.2 -1.4 -1.1 0.0 -2.9 1.9 -0.5
Heart attack 0.9 1.2 7.0 0.5 0.3 0.1 0.0 2.6 0.9 0.0
Allergy 0.1 0.2 0.5 0.7 -0.2 -0.2 0.0 0.7 0.4 0.5
Pain all over the body in last month 0.9 0.9 4.1 -0.7 -0.6 -0.6 0.0 1.2 -0.1 -2.0
Diabetes (self-reported) 1.2 1.8 7.5 1.5 -1.1 -1.2 0.0 2.7 0.6 0.3
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.8 -0.9 0.4 0.4 0.0 -0.1 -0.7 0.6
Medication: Ramipril 0.4 0.6 1.3 -0.8 1.0 0.8 0.0 0.6 -0.3 -1.1
Medication: Simvastatin 1.5 2.3 5.2 -1.9 0.1 -0.1 0.0 2.2 -1.4 -2.3
Fluid intelligence score 0.6 1.2 6.4 -0.5 0.3 0.3 0.0 -0.7 -2.5 -1.1
Illnesses of siblings 0.9 1.3 3.7 1.4 -0.1 0.1 0.0 1.9 -0.1 1.8
Neuroticism score 0.3 0.7 2.6 0.8 -0.2 -0.2 0.0 0.2 1.6 -1.2
Weight 0.1 0.6 3.3 -0.5 0.1 0.1 0.0 1.8 0.3 0.5
Impedance of arm (right) 0.4 1.7 4.0 2.0 -0.8 -0.9 0.0 -2.0 1.5 -0.6
Arm fat percentage (right) 0.2 0.7 2.2 0.3 1.0 0.9 0.0 1.5 0.8 0.3
Trunk fat-free mass 0.1 0.7 3.6 -0.7 -0.1 0.0 0.0 1.9 0.2 0.8
Hip circumference 0.2 1.1 5.9 -0.1 0.3 0.4 0.0 2.4 0.7 0.9
Time employed in main current job 0.7 0.8 1.5 1.2 -1.2 -1.0 0.0 -0.8 1.1 0.2
Alcohol intake versus 10 years previously 0.4 0.6 1.6 1.2 -0.5 -0.9 0.0 -0.2 1.3 -0.2
Father’s age at death 0.5 0.7 1.5 0.6 -0.4 -0.7 0.0 -1.0 1.2 -1.0
Worrier / anxious feelings 0.4 0.7 2.7 0.5 1.0 0.8 0.0 -0.7 0.2 -1.7
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 3.8 1.3 -1.8 -2.0 0.0 0.6 1.2 -0.5
Falls in the last year 0.6 0.8 1.7 -0.3 1.3 1.2 0.0 -0.9 -0.3 1.3
Hair/balding pattern: Pattern 3 0.2 0.3 1.3 -0.7 -0.1 0.1 0.0 1.1 -0.0 -0.2
Number of live births 0.8 1.1 2.1 0.3 1.3 1.3 0.0 1.3 0.5 1.4
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 1.5 0.5 -0.5 -0.4 0.0 -0.3 0.6 1.2
Pulse rate 0.3 0.4 2.0 1.4 0.1 0.0 0.0 0.4 0.6 0.8
Happiness 1.5 1.9 3.8 -0.5 1.7 2.0 0.0 1.9 -0.5 1.5
Noisy workplace 0.6 0.7 2.7 -1.7 -0.6 -0.6 0.0 0.1 -0.3 -1.1
Qualifications: A levels/AS levels or equivalent 0.4 0.9 2.3 1.4 0.7 0.7 0.0 -1.5 0.3 0.9
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 5.0 0.8 -0.9 -0.9 0.0 2.2 0.5 0.8
Mouth/teeth dental problems: Dentures 0.9 1.5 7.3 -0.6 0.6 0.4 0.0 2.7 -1.5 -0.6
Asthma 0.5 1.0 3.7 -0.7 -0.7 -0.9 0.0 -1.0 -0.8 -1.9
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.7 4.4 0.6 2.1 2.0 0.0 0.9 1.2 0.8
Medication: Cholesterol lowering 0.8 1.2 5.6 -0.2 -0.6 -0.7 0.0 1.3 -0.4 -2.4
Depression (self-reported) 0.6 0.7 2.3 1.2 -0.3 -0.6 0.0 0.4 0.6 -1.5
Medication: Lansoprazole 0.5 0.5 1.4 -0.1 0.9 1.1 0.0 -0.1 -0.7 -1.2
Prospective memory result 0.1 0.1 0.6 0.3 -0.2 -0.2 0.0 -0.4 0.8 0.0
Lung cancer (father) 0.5 0.6 1.3 0.7 -0.8 -0.8 0.0 0.5 0.7 1.1
Illnesses of mother 1.0 1.2 3.4 -1.1 -0.7 -0.6 0.0 -1.6 -1.8 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.8 -0.1 -0.3 -0.1 0.0 -1.4 0.5 0.9
Pulse wave Arterial Stiffness index 0.4 0.5 1.0 -0.6 -0.8 -0.7 0.0 0.8 -1.0 -0.6
Impedance of arm (left) 0.2 1.1 4.8 1.0 -0.7 -0.7 0.0 -2.2 0.5 -0.7
Arm fat mass (right) 0.2 0.8 3.9 -0.1 0.7 0.6 0.0 2.0 0.6 0.4
Trunk predicted mass 0.1 0.7 3.5 -0.7 -0.1 -0.0 0.0 1.9 0.3 0.7
Standing height 0.1 0.6 2.3 0.3 -1.5 -1.2 0.0 -0.7 0.1 -0.3
Length of working week for main job 0.3 0.3 0.8 0.2 -0.9 -0.5 0.0 -0.3 -0.3 0.9
Exposure to tobacco smoke at home 0.4 0.5 1.1 0.0 -0.8 -0.7 0.0 1.0 1.1 -0.1
Breastfed as a baby 1.0 1.3 3.1 -0.9 0.9 1.1 0.0 -1.8 -1.7 -0.1
Tense / ‘highly strung’ 0.1 0.2 0.8 -0.4 -0.5 -0.4 0.0 -0.4 0.3 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 2.8 -0.3 -0.2 -0.4 0.0 0.0 1.3 -1.7
Hair/balding pattern: Pattern 4 0.5 1.3 3.3 1.2 -1.8 -1.8 0.0 0.5 0.2 -0.8
Birth weight of first child 0.6 1.0 1.9 -1.3 0.7 0.7 0.0 -1.4 -1.1 1.1
Peak expiratory flow (PEF) 0.5 1.1 2.2 1.0 -1.2 -1.0 0.0 1.0 1.1 1.5
Pulse wave reflection index 0.7 0.8 2.3 -1.5 -0.6 -0.4 0.0 0.2 -1.3 -1.1
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.3 -1.1 -0.2 -0.0 0.0 1.1 -0.9 -0.9
Loud music exposure frequency 0.4 0.5 1.9 -0.2 -0.3 -0.5 0.0 -1.0 0.1 -1.4
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 3.1 0.9 0.7 0.7 0.0 -0.9 0.3 -1.8
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 2.0 -0.6 0.4 0.5 0.0 1.2 -0.5 1.4
Blood clot in the leg (DVT) 0.7 0.9 3.0 1.7 1.0 0.7 0.0 -0.3 1.2 0.1
Medication: Paracetamol 0.3 0.6 1.8 0.3 0.3 -0.1 0.0 1.4 0.4 -1.3
Headache pain in last month 0.8 1.4 3.2 0.8 -1.8 -1.8 0.0 -0.7 0.6 -1.5
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 6.1 1.5 -0.4 -0.4 0.0 -1.0 1.0 2.5
Glaucoma (self-reported) 0.6 0.6 2.1 1.4 -0.7 -0.9 0.0 0.0 0.8 -0.8
Gout (self-reported) 0.2 0.2 1.0 0.7 0.0 -0.3 0.0 0.2 0.4 -1.0
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 2.2 -0.8 0.4 0.6 0.0 0.4 0.9 -1.5
Medication: Amlodipine 0.5 0.7 1.6 0.1 -1.3 -1.2 0.0 1.1 -0.2 -0.5
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.2 0.6 0.9 0.6 0.0 0.2 1.1 0.2
Birth weight 0.7 1.5 5.2 -1.0 -2.3 -1.7 0.0 0.3 -1.0 0.5
Chronic bronchitis/emphysema (mother) 1.6 1.9 7.7 2.8 0.2 -0.3 0.0 0.3 1.8 -1.5
High blood pressure (siblings) 0.4 0.6 2.5 -0.7 -0.6 -0.6 0.0 -0.4 0.2 -1.6
Forced vital capacity (FVC), Best measure 0.2 0.6 2.1 -0.2 -0.2 0.1 0.0 -1.3 0.0 1.5
Body fat percentage 0.1 0.3 1.1 -0.1 0.7 0.5 0.0 1.1 0.1 0.2
Leg fat percentage (right) 0.2 0.7 1.7 -0.4 1.3 1.1 0.0 1.3 -0.1 0.4
Arm fat-free mass (right) 0.1 0.7 3.3 -1.0 -0.2 -0.1 0.0 1.8 -0.4 0.4
Exposure to tobacco smoke outside home 0.4 0.5 3.0 -0.6 -0.1 0.0 0.0 1.7 0.4 0.4
Comparative body size at age 10 0.2 0.6 1.3 -0.7 -0.7 -0.5 0.0 1.1 -0.5 -1.1
Number of full brothers 0.3 0.4 1.1 -0.7 0.6 1.0 0.0 -0.3 0.1 0.8
Worry too long after embarrassment 0.7 1.2 3.4 -0.2 1.3 0.8 0.0 1.5 0.1 -1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 4.2 0.9 -0.3 -0.4 0.0 -0.9 2.0 -0.1
Wheeze or whistling in the chest in last year 0.6 1.0 3.2 0.9 -0.7 -1.0 0.0 0.9 1.8 -0.7
Number of children fathered 1.4 1.6 5.1 2.3 -0.6 -0.4 0.0 -1.0 1.8 1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 1.6 0.4 0.1 0.1 0.0 -0.0 1.3 0.7
Age at first live birth 1.4 2.5 8.1 2.9 -1.8 -1.8 0.0 -0.5 0.9 -1.2
Pulse wave peak to peak time 0.4 0.5 0.7 0.3 0.8 0.8 0.0 -0.8 0.8 0.7
Health satisfaction 1.2 1.6 5.4 1.8 0.3 0.1 0.0 2.3 1.5 -0.0
Shortness of breath walking on level ground 1.0 1.1 3.6 1.4 0.2 -0.3 0.0 1.1 1.0 -1.9
Qualifications: College or University degree 1.3 3.9 7.2 -0.5 2.3 2.5 0.0 -2.7 -1.4 2.6
Eye problems/disorders: None of the above 0.7 0.8 2.2 -1.0 -0.9 -0.8 0.0 -0.9 -1.5 -0.2
Mouth/teeth dental problems: Loose teeth 0.8 0.9 5.7 0.1 -0.2 -0.2 0.0 2.4 -0.3 -0.7
Emphysema/chronic bronchitis 0.5 0.6 2.2 1.5 -0.8 -0.7 0.0 -0.2 0.7 -0.1
Medication for pain relief, constipation, heartburn 0.8 1.4 7.1 -0.0 -1.0 -0.6 0.0 -2.7 0.2 1.0
Neck or shoulder pain in last month 1.0 1.5 3.8 -2.0 1.3 1.5 0.0 0.1 -0.2 1.6
Medication: Blood pressure 0.5 0.9 2.2 -0.8 1.0 1.0 0.0 1.2 -0.1 -1.5
Angina (self-reported) 0.5 0.7 1.7 -0.5 -0.2 -0.2 0.0 1.3 -1.0 -1.3
Migraine (self-reported) 0.8 1.1 2.3 0.3 1.4 1.5 0.0 1.5 0.3 0.9
Medication: Ibuprofen 2.3 2.8 7.5 0.5 2.7 2.7 0.0 0.5 1.7 1.0
Medication: Allopurinol 0.5 0.6 1.4 0.6 -0.9 -1.2 0.0 -0.4 0.5 -1.2
Medication: Omeprazole 0.4 0.4 0.9 -0.7 0.7 0.6 0.0 0.8 0.3 1.0
Medication: Seretide 50 evohaler 0.9 1.0 2.4 -0.7 -1.0 -1.1 0.0 -1.3 -0.5 -1.6
Mean time to correctly identify matches 0.3 0.7 1.6 1.1 0.0 -0.1 0.0 1.3 1.2 0.6
Heart disease (mother) 1.3 1.6 6.7 0.8 0.7 0.8 0.0 1.1 2.6 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.4 6.0 1.5 0.4 0.3 0.0 0.9 2.4 0.5
Whole body fat mass 0.1 0.5 2.8 -0.2 0.5 0.4 0.0 1.7 0.3 0.4
Leg fat mass (right) 0.2 0.7 3.0 -0.1 0.9 0.8 0.0 1.7 0.3 0.5
Arm predicted mass (right) 0.2 0.8 4.4 -0.9 -0.0 0.0 0.0 2.1 -0.5 0.6
Pulse rate, automated reading 0.3 1.0 5.4 0.7 -0.4 -0.5 0.0 2.3 0.5 -0.1
Alcohol intake frequency. 0.3 0.7 1.8 1.1 -0.7 -0.7 0.0 0.4 0.8 -1.3
Comparative height size at age 10 0.3 1.5 4.5 -0.6 -1.6 -1.4 0.0 -2.1 -0.1 -0.9
Number of full sisters 0.7 0.8 3.9 0.6 -0.8 -0.9 0.0 2.0 0.4 0.4
Suffer from ‘nerves’ 0.6 1.0 3.3 0.3 -0.9 -1.0 0.0 0.8 1.0 -1.8
Overall health rating 0.9 2.0 6.1 0.8 0.3 0.1 0.0 2.3 2.5 1.3
Chest pain or discomfort 0.7 0.9 2.9 1.6 -0.2 -0.6 0.0 0.5 1.7 -0.5
Had major operations 0.6 0.7 1.3 0.8 -1.1 -1.1 0.0 1.0 0.6 -0.3
Age at last live birth 1.3 1.9 6.6 2.6 -1.4 -1.5 0.0 0.8 1.3 -0.2
Family relationship satisfaction 0.0 0.0 0.2 -0.0 0.4 0.3 0.0 -0.0 0.1 -0.1
Leg pain on walking 0.7 0.8 2.6 -0.2 1.6 1.4 0.0 0.3 0.8 0.7
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 0.7 0.8 -0.4 -0.4 0.0 0.7 0.8 -0.4
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 -0.5 0.2 -0.1 0.0 -0.3 -0.1 -0.5
Illness, injury, bereavement, stress in last 2 years 1.9 2.3 6.5 -2.4 0.5 0.7 0.0 -1.7 -2.5 0.0
Medication: Aspirin 0.5 0.7 2.8 0.7 0.2 -0.1 0.0 1.7 0.9 -0.7
Supplements: Vitamin C 0.4 0.5 1.7 0.8 -0.2 -0.3 0.0 -1.3 0.4 -0.9
Knee pain experienced in last month 1.7 2.7 4.4 -1.9 2.1 2.0 0.0 0.4 -1.8 1.8
Hypertension (Self-reported) 0.4 1.2 3.8 -1.4 0.8 1.0 0.0 2.0 0.0 -1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.4 -0.5 1.2 1.0 0.0 0.2 -0.3 -0.9
Illnesses of father: Heart disease 0.2 0.3 1.6 -0.4 -0.2 -0.1 0.0 -0.1 0.5 -1.3
Illnesses of siblings: Diabetes 0.9 1.1 2.8 -0.6 -1.1 -1.3 0.0 -1.2 0.8 -1.7
Smoking status: Previous 2.2 3.3 6.3 2.5 -1.8 -1.9 0.0 1.0 2.4 -1.7
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 2.3 -0.7 -1.0 -0.7 0.0 -1.1 -1.5 -0.4
Whole body fat-free mass 0.1 0.8 5.0 -0.6 -0.1 -0.0 0.0 2.2 0.3 0.7
Leg fat-free mass (right) 0.2 1.0 6.3 -0.2 -0.3 -0.2 0.0 2.5 0.6 0.6
Arm fat percentage (left) 0.2 0.6 1.9 -0.2 1.1 1.0 0.0 1.4 0.2 0.3
Average weekly red wine intake 0.7 1.0 2.2 1.1 1.0 1.0 0.0 -1.4 1.5 0.2
Handedness (chirality/laterality): Left-handed 0.5 0.6 2.0 -0.2 0.9 1.1 0.0 0.1 0.2 1.4
Mood swings 0.4 0.8 4.6 -0.4 -0.3 -0.4 0.0 -0.6 -0.3 -2.1
Loneliness, isolation 0.2 0.2 0.9 -0.5 0.4 0.3 0.0 0.5 0.2 -0.9
Long-standing illness, disability or infirmity 0.3 0.5 2.1 -0.7 0.7 0.5 0.0 1.4 -0.3 -0.3
Ever had bowel cancer screening 0.2 0.3 0.8 0.2 -0.5 -0.6 0.0 -0.9 -0.4 -0.6
Diabetes diagnosed by doctor 0.5 0.9 4.5 1.2 -0.2 -0.3 0.0 2.1 0.2 0.2
Ever had stillbirth, spontaneous miscarriage or termination 1.8 1.9 4.7 -2.2 1.2 1.2 0.0 -1.1 -2.1 0.6
Friendships satisfaction 0.3 0.4 1.5 1.2 0.2 0.2 0.0 1.0 -0.1 -0.2
Qualifications: nursing, teaching 0.6 0.9 2.0 1.1 1.0 1.0 0.0 -1.4 0.9 0.7
Commuting to job workplace: Walk 0.4 0.4 1.2 1.1 0.6 0.6 0.0 -0.2 0.1 0.8
Eye problems/disorders: Cataract 0.7 0.8 2.4 1.5 0.6 0.5 0.0 1.0 1.1 0.6
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 2.1 -0.2 0.4 0.2 0.0 -0.6 -1.4 -0.4
Medication for cholesterol 0.4 0.5 1.9 0.9 -0.7 -0.6 0.0 -1.4 0.4 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.4 -0.2 0.4 0.3 0.0 0.6 0.7 1.2
Back pain experienced in last month 0.2 0.3 0.7 0.1 -0.5 -0.5 0.0 0.2 0.8 0.7
Mineral and other dietary supplements 0.4 0.5 0.9 -0.6 0.8 0.9 0.0 0.4 -0.9 0.8
Breast cancer (self-reported) 0.8 1.0 2.2 -0.3 -1.5 -1.4 0.0 0.9 -0.6 -1.2
Asthma (self-reported) 0.3 0.7 2.6 -0.8 -0.3 -0.4 0.0 -0.9 -0.8 -1.6
Osteoporosis (self-reported) 0.3 0.3 0.7 0.6 -0.4 -0.7 0.0 0.6 0.4 -0.9
Osteoarthritis (self-reported) 1.9 2.4 6.2 -1.3 2.5 2.3 0.0 0.7 -0.3 1.8
Medication: Aspirin 0.9 1.2 2.7 1.4 -0.2 -0.5 0.0 1.7 1.5 -1.1
Medication: Gliclazide 1.2 1.4 5.4 1.5 0.2 0.3 0.0 -0.6 1.2 2.3
Illnesses of father: None of the above (group 1) 0.5 0.6 2.1 0.3 -0.3 -0.5 0.0 -1.3 -1.5 -0.3
Smoking status: Current 0.2 0.3 1.6 -1.3 0.2 0.2 0.0 -0.1 -0.5 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 6.4 0.2 0.0 -0.1 0.0 -2.5 1.0 -0.3
Whole body water mass 0.2 0.9 5.2 -0.6 -0.1 0.0 0.0 2.3 0.3 0.6
Leg predicted mass (right) 0.2 1.1 6.5 -0.2 -0.3 -0.2 0.0 2.5 0.6 0.6
Arm fat mass (left) 0.2 0.7 4.4 -0.2 0.6 0.5 0.0 2.1 0.3 0.1
Number of self-reported non-cancer illnesses 0.8 1.4 3.3 -1.7 0.6 0.5 0.0 1.8 -0.7 -1.4
Average weekly champagne plus white wine intake 0.8 1.0 4.6 -0.7 -0.6 -0.5 0.0 1.0 -2.2 -0.7
Miserableness 0.3 0.5 1.7 -0.5 0.6 0.6 0.0 0.8 -0.4 -1.3
Guilty feelings 1.0 1.5 3.4 1.9 -1.4 -1.5 0.0 -0.5 1.6 -0.4
Wears glasses or contact lenses 1.0 1.1 3.6 -0.4 1.9 1.9 0.0 -0.0 -0.1 0.9
Ever taken oral contraceptive pill 0.7 0.7 2.2 -1.2 0.2 0.5 0.0 1.1 -0.3 1.5
Hearing aid user 0.1 0.1 0.2 -0.5 0.3 0.3 0.0 0.0 -0.3 0.4
Mother’s age at death 0.2 0.3 1.0 -0.5 0.1 0.2 0.0 -1.0 -0.9 0.2
Financial situation satisfaction 0.6 0.7 1.6 1.1 -0.8 -0.7 0.0 0.7 1.3 0.6
Tinnitus: Yes, now most or all of the time 0.9 1.1 2.8 -1.7 -0.9 -0.7 0.0 -1.3 -1.1 -0.9
Commuting to job workplace: Public transport 0.5 0.7 2.3 0.4 0.2 0.1 0.0 1.4 -0.3 -1.5
Eye problems/disorders: Glaucoma 0.5 0.5 1.6 1.3 -0.4 -0.6 0.0 0.2 0.5 -1.2
Medication: Blood pressure 0.3 0.6 1.5 -1.1 0.6 0.5 0.0 1.2 -0.7 -0.3
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.7 0.2 0.8 1.0 0.0 1.3 0.8 0.2
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.5 0.0 -0.5 -0.5 0.0 -0.2 0.7 -0.2
High cholesterol (Self-reported) 1.0 1.7 5.1 -0.9 -1.1 -1.2 0.0 1.7 -0.8 -2.3
Medication: Bendroflumethiazide 2.5 3.7 7.0 -2.6 2.7 2.2 0.0 2.2 -1.7 -0.0
Medication: Paracetamol 0.2 0.4 1.2 0.4 0.2 -0.2 0.0 1.1 0.6 -0.9
Medication: Lisinopril 1.6 2.0 5.8 -2.2 0.0 0.2 0.0 2.4 -1.7 -0.8
Medication: Atorvastatin 0.6 0.7 1.4 0.8 1.1 1.1 0.0 1.2 0.5 0.1
Illnesses of father: High blood pressure 3.2 4.0 10.0 -2.7 2.8 3.2 0.0 0.8 -0.8 1.3
Alcohol drinker status: Never 0.6 0.7 2.9 0.6 0.3 0.1 0.0 -1.2 0.2 -1.7
Ever smoked 1.2 2.1 5.1 1.9 -1.4 -1.5 0.0 0.7 2.3 -0.9
Basal metabolic rate 0.2 0.9 5.1 -0.6 -0.0 0.1 0.0 2.3 0.4 0.7
Leg fat percentage (left) 0.2 0.8 2.5 -0.3 1.2 1.0 0.0 1.6 -0.1 0.6
Arm fat-free mass (left) 0.1 0.7 4.6 -0.4 -0.0 -0.1 0.0 2.1 0.4 0.2
Number of operations (self-reported) 0.3 0.4 1.3 -1.1 0.3 0.3 0.0 1.1 0.1 0.1
Average weekly beer plus cider intake 0.4 0.6 0.7 -0.9 -0.8 -0.8 0.0 -0.8 0.8 -0.8
Irritability 0.3 0.5 1.2 -0.1 -1.1 -0.9 0.0 -0.9 -0.8 -0.5
Risk taking 0.2 0.4 1.0 -0.3 -1.0 -0.9 0.0 -0.7 -0.1 0.4
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.2 0.5 -0.5 -0.4 0.0 -1.1 0.2 0.3
Fractured/broken bones in last 5 years 0.3 0.3 1.0 0.3 -0.3 -0.3 0.0 0.9 0.4 -1.0
Age started oral contraceptive pill 0.4 0.5 1.1 1.0 -0.1 -0.4 0.0 -0.8 1.0 -0.9
Diastolic blood pressure, automated reading 0.5 1.6 3.4 -1.7 1.6 1.9 0.0 -0.2 -0.7 1.2
Ever depressed for a whole week 1.0 1.2 3.5 -1.9 0.4 0.4 0.0 0.5 -1.5 -1.5
Unable to work because of sickness or disability 0.2 0.3 0.7 -0.9 0.5 0.5 0.0 0.5 0.6 -0.0
Commuting to job workplace: Cycle 0.6 0.7 1.9 -0.6 0.4 0.8 0.0 -1.4 -1.4 0.6
Myopia 0.2 0.2 1.0 -0.2 -0.0 -0.2 0.0 1.0 0.3 0.6
Vascular/heart problems diagnosed by doctor 0.5 1.3 2.8 1.3 -0.9 -1.0 0.0 -1.6 0.4 1.7
Cholesterol lowering medication 1.1 1.6 6.9 -1.3 0.9 0.8 0.0 2.6 0.1 -1.0
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 3.2 -1.1 0.3 0.3 0.0 1.8 -0.7 0.0
Pain experienced in last month 0.3 0.4 1.4 1.2 -0.6 -0.7 0.0 -0.4 -0.5 -0.6
Supplements: Calcium 1.5 1.7 6.6 2.6 -0.6 -0.9 0.0 -0.3 1.9 0.4
Basal cell carcinoma (self-reported) 0.2 0.2 1.1 -0.2 -0.1 0.1 0.0 0.7 -1.1 0.1
Heart attack/myocardial infarction (self-reported) 0.9 1.2 7.1 0.4 0.5 0.3 0.0 2.7 0.7 0.4
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 2.4 1.6 0.7 0.5 0.0 -0.6 1.3 -0.0
Heart disease (siblings) 0.7 0.9 2.2 -1.5 1.5 1.4 0.0 0.1 -0.2 -0.3
Alcohol drinker status: Previous 0.4 0.4 1.1 -0.7 -0.9 -0.8 0.0 1.0 -0.2 0.1
Pack years of smoking 0.9 1.3 5.7 1.2 -0.8 -0.7 0.0 -0.4 1.0 2.4
Impedance of whole body 0.3 1.5 6.3 1.1 -1.0 -1.1 0.0 -2.5 0.1 -0.7
Leg fat mass (left) 0.2 0.7 3.6 -0.0 0.8 0.6 0.0 1.9 0.4 0.6
Arm predicted mass (left) 0.2 0.8 5.1 -0.2 -0.2 -0.3 0.0 2.2 0.5 0.5