[Hub]/) : Traits : HDL Cholesterol : ← →

chr16:66,542,957-69,084,178

Best TWAS P=7.16e-35 · Best GWAS P=8.39e-33 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DUS2L	0.06	0.03	blup	265	0.06	3.7e-08	2.730	6.2	6.3e-10	0.53	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	GFOD2	0.02	0.01	lasso	3	0.01	1.9e-02	9.960	-10.0	1.0e-23	-0.75	0.40	0.42	FALSE
3	CommonMind	Brain Pre-frontal Cortex	NFATC3	0.05	0.02	blup	307	0.02	6.1e-04	10.500	-9.8	1.9e-22	-0.81	0.53	0.37	FALSE
4	CommonMind	Brain Pre-frontal Cortex	PRMT7	0.23	0.19	bslmm	319	0.19	2.2e-22	8.320	8.2	1.8e-16	0.62	1.00	0.00	FALSE
5	CommonMind	Brain Pre-frontal Cortex	TPPP3	0.04	0.03	blup	222	0.03	2.0e-04	5.080	-6.1	9.4e-10	-0.32	0.41	0.03	FALSE
6	CommonMind	Brain Pre-frontal Cortex	TSNAXIP1	0.02	0.03	blup	225	0.01	6.2e-03	10.500	9.2	4.1e-20	0.67	0.30	0.35	FALSE
7	GTEx	Adipose Subcutaneous	NFATC3	0.11	0.03	lasso	5	0.03	7.9e-04	-4.610	-5.3	1.2e-07	-0.25	0.44	0.02	FALSE
8	GTEx	Adipose Subcutaneous	SLC12A4	0.05	0.01	lasso	4	0.03	2.7e-03	11.900	9.4	4.1e-21	0.88	0.02	0.95	FALSE
9	GTEx	Adipose Subcutaneous	PRMT7	0.28	0.23	enet	34	0.26	6.7e-21	-2.580	5.8	7.2e-09	0.53	1.00	0.00	FALSE
10	GTEx	Adipose Subcutaneous	LCAT	0.04	0.04	enet	10	0.03	1.8e-03	11.700	12.3	9.2e-35	0.96	0.01	0.99	TRUE
11	GTEx	Adipose Visceral Omentum	PRMT7	0.29	0.13	enet	35	0.20	2.0e-10	-2.510	6.8	9.5e-12	0.58	1.00	0.00	FALSE
12	GTEx	Adipose Visceral Omentum	LCAT	0.05	0.01	enet	12	0.02	2.7e-02	9.690	8.4	3.7e-17	0.62	0.16	0.25	FALSE
13	GTEx	Adrenal Gland	TSNAXIP1	0.13	0.09	lasso	5	0.09	2.9e-04	11.800	11.6	6.0e-31	0.98	0.40	0.46	FALSE
14	GTEx	Adrenal Gland	SLC12A4	0.08	0.05	enet	10	0.05	6.8e-03	11.700	11.4	7.4e-30	0.89	0.03	0.81	FALSE
15	GTEx	Adrenal Gland	PRMT7	0.22	0.31	lasso	4	0.30	3.1e-11	8.430	8.4	4.2e-17	0.67	0.96	0.04	FALSE
16	GTEx	Artery Aorta	PLA2G15	0.11	0.03	lasso	7	0.07	1.4e-04	10.500	-9.2	3.8e-20	-0.79	0.18	0.55	FALSE
17	GTEx	Artery Aorta	RANBP10	0.11	0.01	enet	11	0.04	2.0e-03	4.150	7.3	2.7e-13	0.62	0.10	0.19	FALSE
18	GTEx	Artery Coronary	PRMT7	0.52	0.31	enet	40	0.34	3.8e-12	3.510	6.0	1.9e-09	0.47	0.98	0.02	FALSE
19	GTEx	Artery Tibial	LCAT	0.04	0.06	enet	9	0.04	1.9e-04	9.240	8.8	1.0e-18	0.70	0.58	0.19	TRUE
20	GTEx	Brain Cerebellar Hemisphere	TSNAXIP1	0.17	0.05	enet	14	0.08	4.0e-03	11.800	11.9	1.0e-32	0.88	0.04	0.88	FALSE
21	GTEx	Brain Cerebellum	PSMB10	0.11	0.03	lasso	4	0.05	1.6e-02	10.300	-8.0	1.7e-15	-0.59	0.08	0.18	FALSE
22	GTEx	Brain Frontal Cortex BA9	TSNAXIP1	0.17	0.16	lasso	5	0.17	3.2e-05	10.600	11.6	2.9e-31	0.94	0.40	0.45	FALSE
23	GTEx	Brain Frontal Cortex BA9	PRMT7	0.33	0.07	enet	19	0.24	3.6e-07	5.910	5.5	3.1e-08	0.60	0.18	0.74	FALSE
24	GTEx	Brain Hippocampus	PARD6A	0.46	0.00	lasso	7	0.02	8.8e-02	-5.230	-7.0	3.7e-12	-0.33	0.02	0.18	FALSE
25	GTEx	Brain Hypothalamus	PRMT7	0.27	0.10	enet	11	0.21	1.2e-05	10.300	9.5	2.9e-21	0.75	0.13	0.61	FALSE
26	GTEx	Brain Hypothalamus	CTRL	0.14	-0.01	lasso	10	-0.01	5.1e-01	-4.880	8.8	9.0e-19	0.67	0.04	0.35	FALSE
27	GTEx	Brain Nucleus accumbens basal ganglia	CTCF	0.11	0.03	lasso	5	0.04	2.4e-02	0.067	5.4	8.1e-08	0.38	0.13	0.06	FALSE
28	GTEx	Brain Nucleus accumbens basal ganglia	DUS2	0.19	0.14	enet	14	0.19	9.7e-06	3.510	5.8	9.0e-09	0.46	0.43	0.10	FALSE
29	GTEx	Brain Putamen basal ganglia	ENKD1	0.25	0.14	enet	39	0.14	3.9e-04	11.700	7.9	2.8e-15	0.63	0.06	0.83	FALSE
30	GTEx	Brain Putamen basal ganglia	PRMT7	0.15	0.04	enet	10	0.05	2.0e-02	4.360	5.2	2.2e-07	0.38	0.08	0.19	TRUE
31	GTEx	Breast Mammary Tissue	PRMT7	0.19	0.15	lasso	6	0.17	4.4e-09	3.730	7.1	1.1e-12	0.52	0.97	0.03	FALSE
32	GTEx	Breast Mammary Tissue (Male)	LCAT	0.13	-0.01	enet	16	-0.01	6.1e-01	3.410	5.2	2.2e-07	0.49	0.03	0.12	FALSE
33	GTEx	Breast Mammary Tissue (Female)	PRMT7	0.16	0.17	enet	20	0.14	7.9e-05	3.730	5.3	9.2e-08	0.44	0.37	0.10	FALSE
34	GTEx	Cells EBV-transformed lymphocytes	PRMT7	0.29	0.22	enet	29	0.20	3.1e-07	2.800	5.9	4.1e-09	0.48	0.97	0.00	FALSE
35	GTEx	Cells EBV-transformed lymphocytes	GFOD2	0.11	0.07	lasso	5	0.05	1.1e-02	10.000	-11.2	6.5e-29	-0.83	0.04	0.62	FALSE
36	GTEx	Cells Transformed fibroblasts	ELMO3	0.16	0.11	enet	9	0.09	1.4e-07	6.040	7.2	6.0e-13	0.47	1.00	0.00	FALSE
37	GTEx	Cells Transformed fibroblasts	TSNAXIP1	0.08	0.02	lasso	4	0.02	8.2e-03	9.500	11.0	6.4e-28	0.92	0.18	0.64	FALSE
38	GTEx	Cells Transformed fibroblasts	SLC12A4	0.09	0.04	enet	26	0.06	1.3e-05	10.300	10.4	3.4e-25	0.86	0.48	0.52	FALSE
39	GTEx	Cells Transformed fibroblasts	PRMT7	0.22	0.18	lasso	9	0.18	2.5e-13	8.430	8.5	1.7e-17	0.68	1.00	0.00	FALSE
40	GTEx	Cells Transformed fibroblasts	LCAT	0.15	0.04	enet	7	0.08	1.4e-06	9.240	10.9	8.9e-28	0.88	0.03	0.96	FALSE
41	GTEx	Esophagus Gastroesophageal Junction	TSNAXIP1	0.09	0.04	lasso	2	0.04	1.5e-02	10.600	9.3	1.4e-20	0.77	0.14	0.19	FALSE
42	GTEx	Esophagus Mucosa	PRMT7	0.25	0.30	enet	20	0.40	5.1e-28	2.730	7.7	1.5e-14	0.62	1.00	0.00	FALSE
43	GTEx	Esophagus Mucosa	GFOD2	0.07	0.04	enet	15	0.06	4.5e-05	11.700	-11.7	7.7e-32	-0.91	0.13	0.86	FALSE
44	GTEx	Esophagus Muscularis	PRMT7	0.34	0.41	enet	18	0.45	2.6e-30	-2.350	6.1	1.2e-09	0.51	1.00	0.00	FALSE
45	GTEx	Heart Left Ventricle	PRMT7	0.13	0.08	enet	10	0.10	8.3e-06	11.700	10.5	6.6e-26	0.84	0.04	0.95	FALSE
46	GTEx	Liver	PRMT7	0.25	0.19	lasso	10	0.20	2.2e-06	-2.540	5.6	1.9e-08	0.46	0.82	0.06	FALSE
47	GTEx	Lung	SLC7A6	0.08	0.09	lasso	5	0.08	1.9e-06	3.640	-5.4	6.5e-08	-0.41	0.91	0.05	FALSE
48	GTEx	Lung	PRMT7	0.26	0.23	lasso	3	0.28	5.4e-22	-2.350	6.2	5.5e-10	0.53	1.00	0.00	FALSE
49	GTEx	Muscle Skeletal	PRMT7	0.11	0.04	lasso	5	0.09	4.2e-09	8.430	9.1	1.1e-19	0.72	0.53	0.47	FALSE
50	GTEx	Nerve Tibial	LCAT	0.08	0.06	lasso	4	0.04	8.4e-04	9.880	9.6	1.3e-21	0.77	0.34	0.61	FALSE
51	GTEx	Ovary	PRMT7	0.22	0.01	lasso	9	0.00	2.8e-01	9.860	8.6	6.8e-18	0.78	0.08	0.21	FALSE
52	GTEx	Pancreas	PARD6A	0.08	0.09	lasso	3	0.08	3.3e-04	9.960	-8.6	7.6e-18	-0.61	0.24	0.12	FALSE
53	GTEx	Pancreas	PRMT7	0.16	0.04	enet	17	0.11	3.2e-05	8.430	8.1	6.3e-16	0.67	0.37	0.58	FALSE
54	GTEx	Pituitary	LCAT	0.13	0.10	enet	10	0.04	3.9e-02	-4.610	5.2	2.3e-07	0.41	0.07	0.15	FALSE
55	GTEx	Prostate	PRMT7	0.36	0.18	enet	25	0.24	1.3e-06	2.730	6.1	8.5e-10	0.50	0.32	0.36	FALSE
56	GTEx	Skin Not Sun Exposed Suprapubic	CTRL	0.13	0.04	lasso	9	0.08	2.7e-05	0.137	6.7	2.6e-11	0.41	0.71	0.14	FALSE
57	GTEx	Skin Sun Exposed Lower leg	PLA2G15	0.07	0.03	enet	8	0.04	6.0e-04	2.770	5.2	2.3e-07	0.48	0.70	0.18	FALSE
58	GTEx	Skin Sun Exposed Lower leg	SLC12A4	0.04	0.03	lasso	3	0.03	3.1e-03	9.720	9.8	8.8e-23	0.78	0.40	0.44	FALSE
59	GTEx	Skin Sun Exposed Lower leg	PRMT7	0.16	0.13	lasso	6	0.22	3.3e-18	2.490	6.6	3.7e-11	0.54	1.00	0.00	FALSE
60	GTEx	Skin Sun Exposed Lower leg	CTRL	0.05	0.02	enet	6	0.03	1.9e-03	11.800	11.2	5.5e-29	0.82	0.05	0.93	FALSE
61	GTEx	Skin Sun Exposed Lower leg	GFOD2	0.05	0.00	enet	11	0.06	1.6e-05	11.700	-10.2	2.5e-24	-0.74	0.02	0.92	FALSE
62	GTEx	Skin Sun Exposed Lower leg	LCAT	0.07	0.06	lasso	6	0.05	4.1e-05	9.720	9.4	5.8e-21	0.73	0.97	0.03	FALSE
63	GTEx	Testis	NFATC3	0.23	0.16	lasso	7	0.17	6.0e-08	10.500	9.7	5.1e-22	0.87	0.20	0.79	FALSE
64	GTEx	Testis	PRMT7	0.13	0.04	enet	30	0.06	1.6e-03	11.900	6.7	2.5e-11	0.59	0.02	0.96	FALSE
65	GTEx	Testis	DUS2	0.15	0.01	enet	9	0.03	1.1e-02	10.700	6.6	4.2e-11	0.68	0.03	0.90	TRUE
66	GTEx	Testis	LCAT	0.12	0.09	enet	19	0.07	5.3e-04	10.500	10.7	7.6e-27	0.89	0.17	0.79	FALSE
67	GTEx	Testis	RP11-96D1.7	0.14	0.12	lasso	3	0.13	2.3e-06	10.600	-9.8	1.5e-22	-0.88	0.76	0.22	FALSE
68	GTEx	Testis	RP11-67A1.2	0.20	0.02	lasso	6	0.09	8.3e-05	10.500	7.5	6.0e-14	0.72	0.17	0.75	FALSE
69	GTEx	Thyroid	TSNAXIP1	0.04	0.02	lasso	2	0.02	2.3e-02	11.900	11.9	9.7e-33	0.99	0.14	0.59	FALSE
70	GTEx	Thyroid	PRMT7	0.28	0.27	lasso	10	0.35	1.8e-27	-2.580	6.0	1.6e-09	0.52	1.00	0.00	FALSE
71	GTEx	Vagina	PRMT7	0.26	0.17	enet	14	0.23	5.6e-06	2.680	6.0	1.5e-09	0.44	0.26	0.21	FALSE
72	GTEx	Whole Blood	LCAT	0.05	0.04	lasso	4	0.05	3.2e-05	10.600	10.6	3.4e-26	0.92	0.53	0.39	FALSE
73	METSIM	Adipose	ACD	0.02	0.03	lasso	4	0.02	2.4e-04	10.300	-10.4	2.3e-25	-0.83	0.12	0.68	FALSE
74	METSIM	Adipose	ATP6V0D1	0.13	0.03	bslmm	210	0.07	3.5e-11	1.960	-5.7	9.7e-09	-0.07	0.98	0.00	FALSE
75	METSIM	Adipose	DUS2	0.05	0.03	blup	260	0.04	2.4e-07	9.720	9.7	2.0e-22	0.81	0.91	0.09	FALSE
76	METSIM	Adipose	ELMO3	0.05	0.05	blup	236	0.05	6.5e-08	4.120	5.7	1.6e-08	0.42	0.93	0.07	FALSE
77	METSIM	Adipose	PLA2G15	0.03	0.01	blup	287	0.01	4.8e-03	-3.220	-7.3	2.2e-13	-0.56	0.22	0.10	FALSE
78	METSIM	Adipose	PRMT7	0.37	0.04	bslmm	311	0.14	3.6e-20	8.610	6.3	2.5e-10	0.62	0.61	0.39	FALSE
79	NTR	Blood	DPEP3	0.01	0.01	blup	242	0.02	2.8e-06	9.860	-9.2	4.3e-20	-0.77	0.31	0.67	FALSE
80	NTR	Blood	DUS2L	0.01	0.01	bslmm	263	0.01	3.6e-03	9.720	8.0	1.1e-15	0.65	0.42	0.36	FALSE
81	NTR	Blood	ESRP2	0.03	0.03	lasso	5	0.02	7.7e-08	9.800	-9.7	3.3e-22	-0.84	0.58	0.42	FALSE
82	YFS	Blood	DPEP2	0.04	0.02	blup	234	0.05	2.3e-15	9.670	10.2	1.9e-24	0.83	0.39	0.61	FALSE
83	YFS	Blood	DUS2L	0.19	0.23	enet	28	0.28	3.8e-91	9.690	7.8	6.4e-15	0.56	1.00	0.00	FALSE
84	YFS	Blood	LCAT	0.07	0.06	lasso	6	0.06	4.9e-20	10.500	10.7	1.5e-26	0.93	0.98	0.02	FALSE
85	YFS	Blood	NFATC3	0.13	0.07	enet	36	0.10	7.1e-31	9.800	7.8	9.5e-15	0.80	0.98	0.02	FALSE
86	YFS	Blood	PRMT7	0.07	0.04	enet	15	0.05	4.6e-15	8.430	6.8	7.4e-12	0.59	1.00	0.00	FALSE
87	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	B3GNT9	0.03	0.03	blup	26	0.02	1.3e-02	5.590	5.5	3.9e-08	0.38	0.01	0.86	TRUE
88	The Cancer Genome Atlas	Breast Invasive Carcinoma	FHOD1	0.03	0.01	lasso	6	0.02	3.1e-04	-4.240	6.3	3.3e-10	0.34	0.02	0.72	FALSE
89	The Cancer Genome Atlas	Breast Invasive Carcinoma	GFOD2	0.02	0.00	blup	21	0.01	5.0e-03	9.960	-9.4	3.9e-21	-0.56	0.02	0.25	FALSE
90	The Cancer Genome Atlas	Breast Invasive Carcinoma	LCAT	0.01	0.02	blup	18	0.02	2.7e-04	10.100	8.9	4.7e-19	0.67	0.10	0.38	FALSE
91	The Cancer Genome Atlas	Breast Invasive Carcinoma	LRRC36	0.04	0.04	enet	8	0.05	5.8e-10	4.190	5.3	9.5e-08	0.09	0.28	0.68	FALSE
92	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PRMT7	0.24	0.13	blup	58	0.16	1.6e-08	8.350	6.6	3.2e-11	0.57	0.01	0.98	FALSE
93	The Cancer Genome Atlas	Colon Adenocarcinoma	LRRC29	0.05	0.05	blup	33	0.05	5.4e-04	4.650	-5.3	1.1e-07	-0.37	0.03	0.92	FALSE
94	The Cancer Genome Atlas	Colon Adenocarcinoma	PRMT7	0.21	0.10	lasso	8	0.19	3.5e-11	8.320	7.6	4.1e-14	0.57	0.01	0.99	FALSE
95	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PRMT7	0.19	0.08	enet	12	0.09	2.7e-10	8.350	6.0	2.6e-09	0.56	0.01	0.99	FALSE
96	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DUS2L	0.07	0.04	lasso	2	0.03	6.4e-04	9.880	9.8	7.5e-23	0.81	0.09	0.81	FALSE
97	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FHOD1	0.24	0.06	enet	14	0.06	2.3e-07	-4.240	5.2	2.1e-07	0.07	0.69	0.25	TRUE
98	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PRMT7	0.25	0.15	lasso	6	0.17	9.1e-19	8.320	8.2	2.4e-16	0.64	0.01	0.99	FALSE
99	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PRMT7	0.15	0.10	lasso	2	0.11	5.1e-07	8.610	8.4	5.5e-17	0.62	0.00	1.00	FALSE
100	The Cancer Genome Atlas	Brain Lower Grade Glioma	DUS2L	0.09	0.07	enet	7	0.08	3.8e-09	-6.580	9.1	1.1e-19	0.65	0.17	0.82	FALSE
101	The Cancer Genome Atlas	Brain Lower Grade Glioma	NRN1L	0.03	0.00	blup	24	0.01	5.6e-02	10.300	8.3	1.1e-16	0.69	0.01	0.22	TRUE
102	The Cancer Genome Atlas	Brain Lower Grade Glioma	PRMT7	0.19	0.14	enet	5	0.15	6.9e-17	8.430	8.4	5.2e-17	0.70	0.01	0.99	FALSE
103	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C16orf86	0.12	0.01	blup	16	0.02	3.4e-02	-6.180	10.2	2.5e-24	0.57	0.00	0.21	FALSE
104	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	E2F4	0.08	0.00	blup	33	0.02	2.4e-02	4.180	-5.7	1.1e-08	-0.37	0.01	0.48	FALSE
105	The Cancer Genome Atlas	Lung Adenocarcinoma	PRMT7	0.05	0.05	lasso	1	0.04	5.3e-06	8.350	8.3	6.9e-17	0.64	0.01	0.98	FALSE
106	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PRMT7	0.15	0.18	lasso	4	0.18	1.4e-20	8.320	8.2	2.2e-16	0.61	0.02	0.98	FALSE
107	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PRMT7	0.05	0.01	blup	58	0.02	9.0e-03	2.490	6.1	1.1e-09	0.53	0.02	0.79	FALSE
108	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PRMT7	0.22	0.06	lasso	4	0.11	2.7e-05	8.610	8.3	7.2e-17	0.59	0.00	0.98	FALSE
109	The Cancer Genome Atlas	Prostate Adenocarcinoma	DPEP3	0.04	0.02	blup	17	0.03	9.0e-04	10.100	-7.0	2.0e-12	-0.58	0.02	0.08	FALSE
110	The Cancer Genome Atlas	Prostate Adenocarcinoma	FHOD1	0.08	0.08	lasso	10	0.09	2.4e-09	5.030	5.2	2.4e-07	0.28	0.07	0.93	FALSE
111	The Cancer Genome Atlas	Prostate Adenocarcinoma	GFOD2	0.04	0.03	blup	21	0.03	6.0e-04	10.000	-7.5	4.3e-14	-0.54	0.02	0.25	FALSE
112	The Cancer Genome Atlas	Prostate Adenocarcinoma	LCAT	0.07	0.00	blup	17	0.02	4.9e-03	9.280	9.2	3.1e-20	0.65	0.01	0.11	FALSE
113	The Cancer Genome Atlas	Prostate Adenocarcinoma	PRMT7	0.21	0.12	lasso	4	0.12	6.5e-13	8.320	7.8	4.6e-15	0.61	0.02	0.98	FALSE
114	The Cancer Genome Atlas	Stomach Adenocarcinoma	FBXL8	0.04	0.01	enet	8	0.02	6.7e-03	3.970	-5.2	2.6e-07	-0.34	0.02	0.62	FALSE
115	The Cancer Genome Atlas	Testicular Germ Cell Tumors	GFOD2	0.37	0.01	lasso	4	0.03	4.2e-02	-6.180	12.3	7.2e-35	0.64	0.00	0.48	TRUE
116	The Cancer Genome Atlas	Thyroid Carcinoma	PRMT7	0.27	0.15	blup	58	0.18	9.1e-18	8.610	6.8	1.3e-11	0.60	0.00	1.00	FALSE