[Hub]/) : Traits : HDL Cholesterol : ← →

chr20:43,766,067-45,235,570

Best TWAS P=8.26e-16 · Best GWAS P=1.9e-22 conditioned to 2.18e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Visceral Omentum NEURL2 0.20 0.06 lasso 3 0.06 4.2e-04 -9.4 7.2 8.5e-13 -0.73 0.02 0.88 FALSE
2 GTEx Artery Coronary PLTP 0.34 0.07 lasso 5 0.10 2.6e-04 -8.9 7.4 1.4e-13 -0.73 0.06 0.50 FALSE
3 GTEx Brain Cerebellar Hemisphere SNX21 0.41 0.09 enet 16 0.05 2.1e-02 -5.3 -5.6 2.4e-08 0.54 0.04 0.54 FALSE
4 GTEx Brain Cerebellar Hemisphere RP3-337O18.9 0.18 0.00 lasso 5 0.00 4.0e-01 -6.2 5.3 1.4e-07 -0.60 0.08 0.50 FALSE
5 GTEx Nerve Tibial PLTP 0.11 0.01 enet 27 0.01 4.6e-02 -4.1 6.8 1.2e-11 -0.57 0.02 0.90 FALSE
6 ROSMAP Brain Pre-frontal Cortex CTSA 0.15 0.06 enet 20 0.12 7.7e-15 -8.9 6.5 9.1e-11 -0.66 0.06 0.94 TRUE
7 The Cancer Genome Atlas Breast Invasive Carcinoma PLTP 0.04 0.01 lasso 3 0.01 6.4e-04 6.4 5.7 1.5e-08 -0.17 0.13 0.03 FALSE
8 The Cancer Genome Atlas Glioblastoma Multiforme MMP9 0.25 0.16 enet 6 0.16 1.2e-05 -5.3 6.0 2.6e-09 -0.48 0.03 0.44 TRUE
9 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PLTP 0.17 0.03 blup 52 0.06 7.0e-07 -9.7 6.4 1.7e-10 -0.51 0.00 0.99 FALSE
10 The Cancer Genome Atlas Lung Adenocarcinoma ZSWIM1 0.04 0.01 blup 41 0.01 9.5e-03 -9.7 -8.1 8.3e-16 0.78 0.00 0.81 TRUE
11 The Cancer Genome Atlas Pancreatic Adenocarcinoma PLTP 0.34 0.00 lasso 3 0.05 2.8e-03 -9.4 5.9 3.2e-09 -0.55 0.01 0.31 FALSE
12 The Cancer Genome Atlas Soft Tissue Sarcoma PLTP 0.15 0.03 blup 51 0.05 1.1e-03 -9.4 7.3 3.0e-13 -0.50 0.00 0.66 TRUE