Hub : Genes

PLTP

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2160	0.0560	9.3e-06	0.050	0.057	0.039	0.060	0.041	9.2e-07	1.5e-07	1.3e-05	7.4e-08	8.2e-06
2	GTEx	Artery Coronary	0.3360	0.1500	6.8e-03	0.069	NA	0.023	NA	0.103	2.5e-03	NA	5.4e-02	NA	2.5e-04
3	GTEx	Esophagus Mucosa	0.1530	0.0590	2.9e-03	0.086	NA	0.023	NA	0.084	2.2e-06	NA	1.1e-02	NA	3.0e-06
4	GTEx	Nerve Tibial	0.1061	0.0479	2.0e-03	0.005	NA	0.012	NA	0.012	1.3e-01	NA	4.7e-02	NA	4.8e-02
5	METSIM	Adipose	0.2182	0.0493	1.3e-09	0.074	0.088	0.101	0.096	0.094	3.7e-11	4.7e-13	6.7e-15	3.3e-14	5.9e-14
6	TCGA	Breast Invasive Carcinoma	0.0426	0.0214	7.5e-04	0.008	0.011	0.011	NA	0.014	6.4e-03	1.9e-03	1.6e-03	NA	6.4e-04
7	TCGA	Head and Neck Squamous Cell Carcinoma	0.0406	0.0199	4.7e-04	0.035	0.022	0.020	NA	0.026	7.2e-05	1.4e-03	2.2e-03	NA	6.2e-04
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.1734	0.0564	1.5e-06	0.030	0.055	0.049	NA	0.032	2.4e-04	7.0e-07	3.0e-06	NA	1.3e-04
9	TCGA	Brain Lower Grade Glioma	0.0390	0.0221	9.6e-03	-0.001	0.017	0.005	NA	-0.001	4.3e-01	4.5e-03	8.4e-02	NA	4.2e-01
10	TCGA	Pancreatic Adenocarcinoma	0.3380	0.1330	2.4e-03	-0.001	0.042	0.034	NA	0.053	3.6e-01	7.6e-03	1.4e-02	NA	2.8e-03
11	TCGA	Pheochromocytoma and Paraganglioma	0.1620	0.0810	8.5e-03	0.006	0.033	0.004	NA	0.023	1.8e-01	1.8e-02	2.2e-01	NA	4.2e-02
12	TCGA	Soft Tissue Sarcoma	0.1540	0.0670	2.2e-03	0.027	0.045	0.031	NA	0.043	9.0e-03	1.1e-03	5.7e-03	NA	1.5e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	1.1	1.8	7.7	0.5	-0.3	2.7	0.9	0.2	0.6	2.8	0.2	0.8	0.8	1.3	1.4
Bipolar Disorder or Schizophrenia	1.1	2.6	5.9	0.9	0.0	2.2	1.8	0.4	2.1	2.4	1.8	1.1	1.0	2.0	1.6
Depressed Affect (Nagel 2018)	0.9	1.9	7.5	-2.2	0.2	-0.5	-0.3	2.7	1.9	0.2	0.1	0.1	-1.7	-1.8	-0.3
Depression (Nagel 2018)	0.6	0.9	2.1	-1.1	-0.2	-1.4	1.1	0.9	-0.1	-1.0	0.3	-0.2	-1.2	-0.9	-1.5
Intelligence (Savage-Jansen 2018)	0.8	2.5	7.1	1.7	0.4	1.5	0.5	-2.7	-2.6	0.8	0.1	1.0	2.4	1.9	-0.3
Neuroticism (Nagel 2018)	0.4	1.0	3.5	-1.5	-0.4	0.2	0.8	1.9	1.3	0.8	1.0	0.9	-1.1	-0.3	-0.6
Schizophrenia (2018)	1.0	2.0	9.0	0.7	0.3	0.8	1.7	0.4	2.2	0.9	3.0	0.7	0.8	2.0	0.7
Schizophrenia vs Biploar Disorder	1.9	2.5	8.3	-1.3	-0.4	-2.9	-1.0	1.1	0.6	-2.4	-0.5	-1.7	-1.9	-1.9	-1.2
Worry (Nagel 2018)	0.4	0.9	3.1	-1.8	-0.8	-0.5	0.5	1.3	1.7	-0.1	0.6	0.1	-1.2	-0.6	-0.4
Alzheimer’s Disease (in mother)	0.7	0.8	2.8	-1.0	-0.6	0.1	-1.3	1.7	1.2	0.5	0.6	0.7	-0.6	-0.0	0.8
Alzheimer’s Disease (in father)	0.5	0.5	2.0	1.0	-0.3	1.0	-0.5	-0.2	-0.2	1.3	0.3	1.4	-0.4	0.1	-0.2
Alzheimer’s Disease (including proxy)	0.5	0.7	1.9	-1.0	-0.7	0.6	-1.0	1.3	0.8	1.1	0.1	0.2	-1.4	-0.3	0.3
Crohns Disease (2017)	3.1	6.7	16.0	4.0	3.6	-1.6	3.7	-2.9	-1.4	-2.2	2.2	0.5	3.2	2.1	0.5
Irritable Bowel Disease (IBD)	1.0	2.4	7.5	2.7	2.2	-0.2	2.2	-1.5	-1.0	-0.5	1.2	0.6	2.1	1.4	0.3
Ulcerative Colitis (UC)	0.2	0.3	1.1	1.1	0.1	1.0	-0.1	0.4	-0.5	0.9	-0.1	0.5	0.4	0.0	0.0
Major Depression (MDD)	0.6	0.7	2.4	0.9	-1.1	0.5	-0.1	1.6	-0.0	0.8	-0.8	0.5	-1.1	-1.2	-0.2
Reaction Time	1.2	2.2	5.6	1.8	1.8	0.1	2.4	-2.1	-2.2	-1.0	-0.4	-1.1	1.6	0.7	-0.1
Verbal and Numeric Reasoning (VNR)	1.4	3.4	12.7	1.9	1.8	0.0	1.3	-3.6	-2.7	-0.7	0.6	0.8	2.5	2.1	0.1
Breast Cancer	1.0	2.3	7.7	-0.5	-1.2	-0.4	-2.1	2.8	2.4	0.6	0.9	1.9	-1.6	-0.7	0.0
Ovarian Cancer	0.4	0.6	2.9	0.0	0.5	-0.7	-1.4	1.7	0.4	-0.5	0.2	0.5	0.1	-0.4	0.3
Prostate Cancer	0.4	0.6	3.0	-0.3	1.7	0.1	0.7	-0.6	-0.5	-0.3	-0.2	-1.5	0.7	-0.2	0.2
Age at First Birth	0.6	0.9	2.3	-0.8	0.2	-0.7	-0.4	1.4	-1.0	-0.5	-1.2	-0.1	-1.2	-1.2	-1.5
Bipolar Disorder (2011)	8.3	8.0	15.3	2.8	1.6	3.0	2.5	-0.3	1.4	3.0	3.2	3.6	3.2	3.1	3.9
Body Mass Index (BMI) (2010)	1.0	1.3	4.0	1.8	1.7	-0.3	1.7	-0.6	-1.1	-0.7	0.5	0.4	2.0	0.5	0.3
Coronary Artery Disease (CAD)	1.8	2.2	4.9	2.2	1.0	0.9	0.3	1.9	1.0	1.2	1.6	2.0	1.4	-0.3	2.2
Crohns Disease (2012)	0.9	1.5	6.0	1.8	2.5	-0.5	1.7	-1.2	-0.7	-0.8	0.5	-0.2	1.3	0.5	0.3
Mean Putamen Volume	0.5	0.6	1.7	0.8	-0.2	1.0	-1.2	0.9	0.2	1.3	-0.2	0.7	-0.7	-0.5	-0.5
Fasting Glucose	0.4	0.5	2.4	-1.6	0.1	-1.0	-0.6	-0.3	0.1	-0.9	-0.2	-0.3	-0.6	-0.6	0.1
HbA1C	1.9	2.1	10.4	1.1	-0.1	-3.2	0.4	-1.7	0.2	-2.8	1.1	0.4	0.8	0.8	0.4
HDL Cholesterol	14.1	23.5	54.7	2.8	7.4	1.2	6.8	-0.5	5.7	0.4	6.4	1.3	5.9	3.1	7.3
LDL Cholesterol	1.4	2.2	8.6	-0.1	-0.9	-1.6	-1.4	-1.7	-2.9	-1.6	-1.5	-0.3	-0.7	-0.3	-1.9
Lupus	1.3	2.0	5.9	0.3	2.1	-1.9	-0.5	1.2	2.4	-1.5	1.8	-0.6	-0.8	-0.7	1.2
Neuroticism (2016)	0.8	1.1	3.6	-1.4	-0.7	-0.4	-0.3	1.8	-0.4	0.2	-0.4	0.4	-1.9	-1.1	-1.5
Primary Biliary Cirrhosis	0.7	1.0	3.1	-0.3	-0.9	1.4	0.0	-0.0	-0.2	1.3	-1.5	-0.8	-1.7	-1.3	-0.4
Rheumatoid Arthritis	0.6	0.8	1.8	0.7	-0.2	-1.2	-1.1	-0.4	-0.6	-1.3	-0.8	-0.4	-0.8	-1.3	-0.9
Schizophrenia (2014)	0.9	1.9	5.7	1.1	0.6	1.0	1.3	0.8	2.1	1.3	2.4	1.1	0.8	1.6	1.2
Triglycerides	12.9	21.2	44.7	-3.0	-6.7	-1.2	-6.6	1.8	-4.3	-0.1	-6.0	-1.8	-6.1	-4.2	-6.3
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.3	1.0	0.1	0.6	0.9	-0.5	-0.5	0.7	0.1	0.9	0.9	0.8	1.1
Ulcerative Colitis	0.5	0.7	3.3	0.7	0.2	1.8	-0.0	0.6	0.8	1.5	0.2	0.2	0.6	0.0	0.7
Blood Eosinophil Count	0.3	2.3	8.2	-0.3	-0.4	2.8	-2.0	0.7	2.1	2.9	0.0	0.1	-1.0	-0.2	1.1
Blood Platelet Count	0.5	6.4	20.5	-0.7	1.8	-0.6	-0.1	2.5	4.5	0.6	3.0	3.7	1.6	0.1	4.4
Blood Red Count	1.5	14.8	40.1	2.9	5.8	-1.2	6.3	-4.4	-0.1	-3.1	3.4	-0.7	6.2	2.4	2.7
Blood White Count	0.5	4.1	11.9	-1.0	-1.4	-3.5	-2.8	0.9	0.5	-2.4	-0.1	1.6	-2.7	-2.6	-1.4
Heel T-Score	2.1	17.1	45.3	-3.5	-4.9	-2.6	-5.7	4.6	0.9	-1.5	-4.3	-2.3	-6.7	-4.8	-3.6
BMI	0.8	4.4	14.8	3.8	2.2	0.3	2.8	-1.7	-0.2	-0.2	2.0	1.7	3.5	1.4	1.0
Height	0.3	6.1	20.4	-3.7	2.6	1.9	4.2	-0.4	-1.6	0.2	-2.1	-4.5	0.3	-1.3	-1.2
Waist Hip Ratio (WHR)	0.2	1.1	4.4	-0.3	-0.7	-1.0	-2.1	0.5	-0.7	-0.5	-0.0	1.6	-1.7	-0.8	-0.6
Systolic Blood Pressure	0.4	2.0	6.5	-1.9	-0.7	-1.5	-1.0	1.9	2.5	-0.7	1.1	1.6	-1.3	-0.8	0.6
Smoking Status	0.4	0.9	2.3	1.0	-1.5	1.3	-1.0	-0.3	-0.4	1.4	0.2	1.2	0.5	0.8	0.1
Allergy or Eczema	1.9	4.9	17.4	2.7	0.5	0.5	2.7	-4.2	-2.1	-0.7	0.7	-0.8	3.2	3.1	-0.6
Cardiovascular Disease	0.9	2.9	7.6	-0.4	-2.8	-2.1	-2.5	2.3	1.3	-1.0	0.3	2.0	-1.4	-1.1	-1.2
Hypothyroidism (self reported)	0.3	0.6	2.9	0.8	0.4	-1.7	0.1	0.3	-0.2	-1.6	0.3	0.6	0.2	-0.6	0.1
Respiratory disease	0.6	1.2	3.1	1.4	1.8	0.4	1.2	-1.4	-0.5	-0.2	0.7	0.9	1.5	0.8	1.4
Type 2 Diabetes (T2D) (2018)	0.7	1.3	4.8	1.5	1.1	-0.3	0.2	0.3	0.4	-0.2	1.3	2.2	1.9	0.7	1.1
Lung FEV1/FVC ratio	0.6	2.8	9.3	0.6	-1.7	-1.9	-3.1	-1.2	-0.8	-1.8	-1.1	0.9	-1.9	-1.9	-1.7
Lung FVC	0.6	3.1	9.5	3.1	0.7	0.3	3.0	-1.8	-2.1	-0.2	-0.2	-0.6	2.4	2.0	0.2
Neuroticism	0.5	1.2	3.4	-1.6	-0.4	0.3	0.1	1.8	1.9	1.0	1.1	1.0	-1.2	-0.2	-0.2
Chronotype (morning person)	1.1	2.4	6.4	-2.4	-0.3	-1.1	-0.3	0.8	0.2	-1.1	-2.0	-2.5	-1.8	-2.1	-1.4
Hair Pigment	0.0	1.0	4.3	0.6	-1.6	-0.8	-2.1	-0.7	-1.1	-0.5	-0.5	0.9	-1.0	-0.7	-0.2
Tanning	0.1	0.9	4.5	-0.4	-0.9	-0.1	-0.6	0.7	2.1	0.4	1.1	0.7	0.6	1.0	1.2
Hand grip strength (left)	0.2	0.5	1.5	-1.1	0.2	0.8	0.8	-0.4	0.3	0.2	0.2	-1.2	1.0	1.1	-0.2
Number of treatments/medications taken	1.0	1.8	4.2	0.7	-2.0	-1.7	-1.3	1.3	0.6	-1.1	-0.3	1.1	-2.1	-1.8	-0.7
Average weekly spirits intake	1.1	1.4	3.8	1.1	1.9	-0.3	-0.3	0.5	1.6	-0.1	1.5	1.9	0.6	-0.5	1.3
Sensitivity / hurt feelings	0.4	0.7	2.3	-0.7	-1.4	0.2	0.4	1.5	0.7	0.6	0.8	0.8	-0.8	0.3	-0.9
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.7	-1.3	-0.6	-0.1	0.8	1.2	0.0	0.0	0.4	-0.3	-0.4	-0.3	-0.6
Hearing difficulty/problems: Yes	2.2	3.3	8.2	2.8	-0.9	-0.7	1.7	-2.7	-1.0	-0.9	1.9	1.9	2.9	2.0	0.3
Relative age of first facial hair	0.5	1.1	2.8	0.1	1.7	1.6	1.5	-0.8	-0.6	1.1	0.2	-0.3	1.2	0.7	0.9
Other serious medical condition/disability diagnosed by doctor	2.4	3.1	10.2	-1.0	-2.2	-1.8	-1.9	1.4	0.3	-1.3	-1.3	-0.6	-3.2	-2.5	-1.7
Ever used hormone-replacement therapy (HRT)	0.9	1.2	4.5	0.1	-0.0	-0.6	-2.1	1.8	1.3	0.0	0.1	1.3	-0.7	-1.3	0.5
Ever had hysterectomy (womb removed)	1.1	1.2	5.0	-0.6	-2.0	-0.1	-1.0	2.2	0.6	0.3	-0.5	-0.3	-1.2	-0.8	-1.3
Systolic blood pressure, automated reading	0.1	0.4	1.8	-1.1	0.5	-0.7	0.2	0.8	1.3	-0.4	0.4	-0.0	-0.4	-0.4	0.5
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	1.0	-0.1	0.5	0.6	-0.7	0.5	0.4	0.4	0.0	0.4	1.0	-0.2	-0.4
Angina	0.6	0.7	1.7	0.3	-1.3	-0.2	-1.1	0.8	1.1	0.3	0.8	1.0	-0.8	-0.3	1.3
Medication for hormone replacement therapy	1.2	1.4	7.0	-0.0	0.3	-0.6	-1.2	1.5	2.6	0.0	1.3	1.0	-0.1	0.2	1.5
Vitamin and mineral supplements	1.0	1.3	3.3	0.6	0.3	-1.8	0.9	-1.2	-1.8	-1.4	-0.6	1.3	-0.4	-0.9	-1.4
Supplements: Zinc	1.3	1.4	6.2	0.2	-2.5	1.1	-0.7	1.8	1.4	1.6	0.4	0.4	0.4	0.9	-0.0
Medication: Co-codamol	0.6	0.7	2.8	0.7	-0.7	-1.3	0.2	0.7	0.3	-0.7	1.1	1.7	-0.7	-0.5	-0.0
Medication: Metformin	0.5	0.8	2.4	0.5	1.6	0.8	-0.5	0.2	0.4	0.9	0.5	1.4	0.9	-0.1	1.3
Diabetes (father)	1.6	1.9	4.8	2.2	0.0	-1.6	1.6	-1.7	-0.0	-1.7	1.0	1.0	1.7	1.5	-0.5
Diabetes (mother)	0.3	0.4	1.3	0.6	-0.7	-1.2	-0.2	-0.4	0.7	-0.9	0.5	0.7	-0.0	0.3	-0.5
Severe depression (siblings)	2.2	2.4	5.4	0.8	1.2	1.9	0.8	2.1	2.3	1.9	1.9	0.6	0.6	0.4	2.2
Pack years adult smoking proportion	0.8	1.3	3.8	-0.7	-1.0	-1.8	-0.4	-0.3	0.9	-2.0	-0.4	-1.7	-0.5	-0.2	-1.5
Impedance of leg (right)	0.4	1.9	5.4	-1.3	0.4	-2.3	-2.0	0.0	0.1	-2.1	-0.5	-0.8	-1.6	-1.8	-0.7
Leg fat-free mass (left)	0.3	1.4	6.2	0.7	1.0	1.5	2.5	-1.3	-0.7	0.7	0.2	-0.3	1.8	1.0	-0.1
Trunk fat percentage	0.2	0.7	3.6	0.7	1.9	-0.6	0.7	-0.7	0.0	-0.7	0.2	0.6	1.1	-0.9	0.5
Hand grip strength (right)	0.1	0.3	0.7	-0.6	0.6	0.6	0.4	-0.4	0.7	0.3	0.8	-0.2	0.8	0.7	0.7
Townsend deprivation index at recruitment	0.6	0.8	2.3	0.7	-0.2	0.7	-0.2	0.4	0.2	0.9	1.1	1.2	1.0	1.5	1.2
Current tobacco smoking	0.3	0.5	1.2	-0.8	-0.6	0.7	-0.8	-0.5	-1.1	0.7	-1.0	0.5	0.0	0.0	-0.7
Average weekly fortified wine intake	1.0	1.1	3.1	-1.0	-0.4	0.8	-1.7	1.8	1.3	1.3	0.0	0.8	-0.7	-0.5	0.9
Maternal smoking around birth	1.2	1.7	3.8	-0.9	-2.0	-0.8	-1.7	2.0	1.1	0.1	-0.7	0.5	-1.9	-0.8	-1.4
Fed-up feelings	0.8	1.4	4.4	-2.1	-0.6	-1.2	-0.7	1.3	1.0	-0.8	-0.1	0.1	-1.8	-1.6	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	6.9	-2.6	-1.0	-1.2	-0.1	1.0	0.4	-0.5	-0.3	0.6	-1.8	-1.5	-0.9
Relative age voice broke	0.5	0.7	2.2	-0.2	0.1	-1.4	-0.2	-0.6	-0.6	-1.5	-1.0	-0.6	-0.8	-1.2	-0.7
Taking other prescription medications	1.0	1.6	4.9	0.7	-2.2	-2.0	-0.6	0.8	1.0	-1.7	-0.3	0.0	-1.4	-1.6	-0.7
Age when periods started (menarche)	0.3	0.8	3.2	-0.6	1.1	-0.7	0.4	-1.8	-0.3	-1.3	0.2	-1.0	0.5	-0.5	0.4
Bilateral oophorectomy (both ovaries removed)	2.7	3.1	8.5	-2.4	-0.9	-0.0	-1.6	1.1	-0.7	0.1	-2.3	-1.3	-2.9	-2.6	-2.2
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	6.1	-1.3	-0.6	-2.5	-0.2	0.2	-0.2	-2.5	-1.1	-1.2	-0.9	-1.1	-2.0
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	4.2	-2.0	1.5	0.7	1.4	0.8	1.8	0.6	0.4	-1.3	-1.2	-1.2	-0.2
Qualifications: CSEs or equivalent	0.4	0.5	2.6	-0.0	0.8	-0.7	-1.6	-0.1	0.3	-0.9	0.1	-0.8	-0.6	-0.3	-0.3
Serious illness, injury or assault to yourself	0.3	0.4	1.7	0.2	0.3	-0.1	0.2	0.3	-0.4	-0.4	-1.0	-1.0	-0.6	-1.3	-0.2
High blood pressure	0.7	2.0	5.3	-0.5	-1.8	-1.9	-2.3	1.7	1.6	-0.9	0.6	1.3	-1.5	-0.6	-0.4
Hayfever, allergic rhinitis or eczema	1.8	4.0	14.8	2.7	0.5	-0.5	1.5	-3.8	-2.3	-1.5	1.1	0.1	2.8	2.4	-0.6
Multivitamins +/- minerals	1.0	1.3	3.9	-0.8	-0.7	1.3	-2.0	1.7	1.5	1.3	-0.0	-0.9	-0.5	-0.2	1.0
Stomach or abdominal pain in last month	1.3	1.6	6.0	-0.9	-1.3	-1.2	-1.3	1.2	0.2	-0.9	-0.6	0.1	-1.9	-2.4	-1.2
Supplements: Glucosamine	0.5	0.7	2.8	0.1	0.8	-0.1	-1.1	1.1	1.1	0.2	0.6	-0.1	-0.8	-0.1	1.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.9	-0.2	0.3	-0.1	0.8	-1.0	-0.3	-0.3	-0.6	-0.9	-0.0	0.2	-0.6
Medication: Atenolol	0.7	0.9	2.9	-0.8	-0.9	-0.9	-1.7	0.9	1.1	-0.2	-0.5	0.5	-1.3	-0.8	0.3
Medication: Levothyroxine sodium	0.5	0.9	3.9	0.2	-0.6	-2.0	-0.5	0.8	-0.2	-1.5	0.2	0.9	-1.0	-1.1	-0.0
Sitting height	0.2	1.5	5.8	-0.6	0.5	-0.1	2.4	-1.7	-1.3	-0.8	-0.3	-1.5	1.2	1.0	-1.0
Chronic bronchitis/emphysema (father)	0.4	0.5	2.9	0.2	0.4	-0.4	0.1	-0.6	-1.2	-0.4	-1.7	-0.2	-0.3	-0.9	0.0
High blood pressure (mother)	0.5	0.6	3.8	-0.6	0.6	0.4	0.7	0.9	0.8	-0.3	-0.3	-2.0	-0.5	-0.6	-0.4
Body mass index (BMI)	0.2	0.8	3.9	1.7	0.8	-0.1	0.3	-0.3	0.4	0.0	0.6	2.0	1.1	-0.2	0.6
Impedance of leg (left)	0.2	0.9	3.3	-1.1	0.4	-1.8	-1.1	-0.1	0.1	-1.7	-0.2	-0.8	-0.6	-0.9	-0.4
Leg predicted mass (left)	0.3	1.4	5.9	0.7	0.9	1.4	2.4	-1.3	-0.8	0.6	0.1	-0.2	1.8	1.0	-0.1
Trunk fat mass	0.2	0.8	3.4	0.8	1.8	0.0	1.2	-0.9	-0.1	-0.3	0.2	0.5	1.5	-0.5	0.5
Waist circumference	0.1	0.4	1.7	1.3	0.5	-0.5	0.4	-0.4	-0.3	-0.4	0.2	1.2	0.6	-0.4	-0.2
Number of incorrect matches in round	1.1	1.9	5.5	-0.9	0.1	0.8	-2.2	2.3	1.8	1.1	-0.9	-0.5	-1.8	-1.4	-0.2
Past tobacco smoking	0.4	0.7	2.7	-1.7	1.5	-0.6	0.6	0.6	0.7	-0.5	-0.0	-0.2	-0.7	-1.0	-0.3
Alcohol usually taken with meals	0.4	0.6	1.4	0.4	-1.2	0.7	-1.1	0.4	1.1	0.7	-0.1	-0.9	-0.8	0.7	-0.4
Nervous feelings	0.4	0.8	2.6	-0.7	-0.6	-0.3	1.6	0.3	0.7	-0.2	1.3	1.0	0.6	1.4	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.8	-1.7	-1.5	0.3	-0.2	-0.1	-0.8	0.6	-0.1	1.3	-0.9	0.0	-0.8
Hearing difficulty/problems with background noise	1.3	2.1	4.8	1.4	-0.4	-0.8	2.0	-1.7	0.3	-1.0	2.2	0.9	2.2	2.0	-0.5
Hair/balding pattern: Pattern 2	0.8	1.1	3.9	0.5	0.7	0.4	0.4	-0.9	-0.1	0.7	0.8	2.0	1.2	0.9	1.8
Had menopause	0.4	0.5	2.1	-0.6	0.1	-0.3	-1.4	0.7	0.0	-0.3	-0.6	-0.5	-0.8	-1.4	0.2
Had other major operations	0.8	0.9	2.3	-0.5	-1.0	-0.3	-1.4	0.8	-0.2	-0.1	-1.3	-0.9	-1.4	-1.5	-0.9
Forced vital capacity (FVC)	1.2	4.4	11.5	2.4	2.0	1.7	3.4	-2.4	-2.0	0.6	0.5	-1.1	3.1	2.8	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	3.0	-0.3	-0.7	-1.7	-1.1	0.9	0.9	-1.3	-0.2	-0.2	-1.2	-0.8	-0.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.4	-0.5	0.3	1.4	0.7	1.6	0.8	1.3	0.4	0.3	0.6	0.5	0.9
Qualifications: None of the above	1.0	2.2	9.9	-1.1	-0.4	-0.3	-1.4	3.1	2.1	0.4	0.2	0.7	-1.9	-2.0	0.3
Financial difficulties in last 2 years	1.5	2.0	4.8	1.1	-1.5	1.7	0.4	1.2	0.0	1.9	1.8	2.2	0.7	1.6	0.9
Mouth/teeth dental problems	0.3	0.4	1.7	-0.9	0.7	0.3	0.3	0.5	0.8	0.1	-0.5	-1.3	-0.7	-0.7	-0.2
Heart attack	0.7	0.9	4.5	1.7	-1.0	-0.6	0.2	0.9	0.6	0.0	0.9	2.1	-0.3	0.1	0.4
Allergy	1.2	2.8	12.0	-2.0	-0.9	0.2	-1.1	3.5	1.9	1.0	-0.5	0.0	-2.4	-2.1	0.2
Pain all over the body in last month	0.8	0.8	3.0	-0.1	-0.3	-1.1	-0.2	0.6	-0.1	-1.0	-0.9	-0.4	-0.9	-1.6	-1.7
Diabetes (self-reported)	1.1	1.6	5.5	1.7	1.1	-0.7	0.4	-0.2	0.3	-0.6	1.6	2.4	2.1	0.9	1.0
Hayfever/allergic rhinitis (self-reported)	2.8	3.7	9.2	2.2	1.5	-2.1	1.9	-3.0	-1.5	-2.6	1.6	0.5	2.0	2.1	-0.2
Medication: Ramipril	1.1	1.5	6.6	0.6	-1.2	-2.6	-1.1	-0.7	-0.2	-1.9	0.5	1.7	-0.8	0.1	-0.5
Medication: Simvastatin	0.8	1.1	6.4	-0.4	-1.0	-1.8	-0.5	0.3	-0.6	-1.2	0.5	2.5	-0.4	-0.7	-0.2
Fluid intelligence score	1.7	3.5	9.4	0.5	2.7	-0.8	1.9	-3.1	-1.8	-1.5	1.1	-0.1	2.9	2.4	0.2
Illnesses of siblings	0.2	0.3	1.2	-0.3	-0.2	0.1	0.4	-1.1	-0.4	0.1	0.2	-0.5	0.6	1.0	-0.5
Neuroticism score	0.6	1.3	3.6	-1.9	-1.3	0.6	-0.5	1.4	0.4	1.0	-0.4	0.3	-1.9	-0.8	-1.4
Weight	0.2	0.8	2.6	1.1	1.5	0.6	1.6	-0.9	-0.3	0.1	0.3	0.5	1.6	-0.0	0.1
Impedance of arm (right)	0.1	0.3	2.1	-0.5	0.8	-0.1	0.0	0.2	0.6	-0.3	0.1	-1.4	0.0	0.2	0.3
Arm fat percentage (right)	0.4	1.5	3.8	2.0	1.5	0.1	1.0	-1.0	0.5	0.1	1.0	1.8	1.9	0.5	1.1
Trunk fat-free mass	0.3	1.8	5.8	0.9	1.0	1.7	2.4	-1.5	-1.3	0.8	0.2	-0.3	2.0	1.5	-0.2
Hip circumference	0.1	0.4	1.6	0.8	0.9	0.6	1.2	-0.3	-0.2	0.4	0.0	0.3	1.3	0.1	-0.1
Time employed in main current job	0.7	0.8	3.8	0.2	0.3	-0.6	-0.6	1.9	2.0	-0.4	0.5	-0.2	-0.9	-0.9	-0.2
Alcohol intake versus 10 years previously	0.6	0.8	2.9	1.1	-0.0	-1.5	-0.9	-0.4	0.6	-1.7	1.4	0.4	-0.0	0.2	-0.2
Father’s age at death	3.5	4.7	10.2	-2.5	-2.1	-0.6	-2.4	0.8	-0.4	-0.6	-3.0	-3.2	-2.8	-2.4	-2.3
Worrier / anxious feelings	1.2	2.3	8.0	-2.1	-0.8	1.6	-0.2	2.8	2.2	2.1	0.7	0.4	-1.2	-0.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	4.4	-1.5	-0.5	-0.2	-0.5	2.1	1.0	0.1	-0.5	-0.2	-1.1	-1.7	-0.6
Falls in the last year	0.2	0.3	1.2	0.6	-0.3	-1.0	0.5	-0.1	-0.0	-1.1	0.1	0.4	0.1	-0.2	-0.5
Hair/balding pattern: Pattern 3	0.8	1.3	4.0	-0.9	-0.2	-2.0	-1.2	0.9	0.6	-1.9	0.8	-0.9	-1.5	-0.2	-0.7
Number of live births	0.6	0.9	3.4	-0.4	-1.3	1.3	-0.5	1.8	0.7	1.4	0.8	0.6	-0.1	0.1	0.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	4.3	2.1	1.0	1.0	2.0	-2.0	-1.7	-0.0	0.3	-0.9	1.9	1.9	-0.2
Pulse rate	2.1	3.5	8.0	-2.3	-0.3	-0.3	-2.2	-0.8	-2.4	-0.8	-1.9	-1.1	-2.3	-2.8	-2.5
Happiness	0.5	0.6	1.6	-1.0	0.8	1.3	-0.8	1.0	-0.1	0.9	-0.5	-0.7	-0.6	-0.4	0.1
Noisy workplace	1.4	1.7	11.6	-0.8	-0.7	-1.3	-0.2	1.5	3.4	-0.8	1.1	-0.3	-1.4	-0.1	0.6
Qualifications: A levels/AS levels or equivalent	2.5	5.4	14.8	2.4	2.1	0.8	3.4	-3.6	-1.6	-0.2	1.7	0.3	3.8	3.0	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	4.0	-1.7	-0.8	-0.2	-0.7	1.6	0.9	-0.2	-1.1	-1.9	-1.8	-2.0	-1.1
Mouth/teeth dental problems: Dentures	0.3	0.5	2.1	0.2	-1.4	-0.2	-0.1	-0.3	-1.4	-0.1	-0.4	0.9	0.3	-0.1	-0.8
Asthma	0.2	0.3	1.3	0.6	0.6	0.2	0.4	-1.1	-0.9	-0.0	-0.0	0.7	0.6	0.2	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.3	-0.8	-1.2	-0.1	-0.8	1.1	0.5	0.0	-0.2	-1.0	-0.4	-0.5	-0.4
Medication: Cholesterol lowering	0.7	1.1	4.7	0.7	-1.8	-0.8	-1.6	0.4	-0.4	-0.1	-0.0	2.2	-0.9	-0.4	-0.6
Depression (self-reported)	0.4	0.4	2.2	-0.3	0.0	0.2	0.9	1.0	1.5	0.1	0.7	-0.4	0.6	0.4	-0.1
Medication: Lansoprazole	0.5	0.6	2.1	0.5	0.2	-1.4	-0.5	0.9	0.8	-1.3	0.8	0.2	-0.2	-0.5	0.0
Prospective memory result	1.3	1.6	6.7	-0.8	-0.5	0.5	-0.5	2.6	2.4	0.6	-0.1	-0.9	-1.1	-1.3	0.9
Lung cancer (father)	0.7	0.8	1.9	-1.0	0.8	-1.2	-0.8	-0.2	-0.8	-0.8	-1.1	0.4	-1.4	-1.2	0.3
Illnesses of mother	0.5	0.6	1.6	-1.2	0.2	-0.2	-1.1	-1.1	-0.8	0.2	-0.2	1.3	-0.4	-0.6	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.7	6.2	1.9	1.3	1.2	2.4	-2.3	-1.7	-0.1	0.4	-1.2	2.5	1.9	-0.2
Pulse wave Arterial Stiffness index	1.0	1.2	5.4	-0.5	2.3	0.7	2.0	-0.1	-0.2	0.4	1.0	0.2	1.3	-0.3	0.9
Impedance of arm (left)	0.1	0.4	1.4	-1.2	0.7	-0.2	-0.1	0.6	0.7	-0.0	0.0	-1.0	-0.4	-0.4	0.7
Arm fat mass (right)	0.4	1.5	4.8	1.9	1.3	0.7	1.4	-1.1	-0.1	0.5	0.7	1.4	2.2	0.8	0.8
Trunk predicted mass	0.3	1.8	5.6	0.8	1.1	1.8	2.4	-1.4	-1.3	0.9	0.2	-0.2	2.0	1.5	-0.1
Standing height	0.3	2.9	10.2	-1.2	1.8	1.3	3.2	-1.5	-1.7	-0.0	-0.5	-3.1	1.3	0.7	-1.0
Length of working week for main job	1.8	2.0	4.9	-1.9	-0.2	-2.1	-1.0	-0.4	0.4	-2.2	-0.7	-1.3	-1.9	-1.5	-1.1
Exposure to tobacco smoke at home	0.3	0.3	1.4	-0.6	-0.3	0.0	-1.2	0.0	0.1	0.3	-0.6	0.8	-0.5	-0.7	0.8
Breastfed as a baby	0.4	0.5	2.4	0.6	-0.1	-1.4	0.4	-0.6	-0.6	-1.5	0.2	-0.4	0.0	0.3	-0.4
Tense / ‘highly strung’	0.4	0.6	1.5	-1.1	-1.2	-0.4	-0.3	0.9	0.1	-0.0	0.2	0.9	-0.9	-0.7	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	5.4	-0.9	-0.8	2.0	0.5	2.3	1.8	2.3	0.3	0.6	-0.3	-0.1	0.8
Hair/balding pattern: Pattern 4	0.2	0.4	2.3	-1.5	-0.8	0.1	0.2	-0.0	1.0	0.1	-0.7	-0.6	-0.3	-0.4	0.1
Birth weight of first child	1.2	2.2	12.3	1.1	-1.0	-0.9	-0.4	-2.2	-3.5	-0.8	-1.6	0.9	-0.5	-0.1	-1.4
Peak expiratory flow (PEF)	0.3	0.8	3.7	-0.3	-1.1	0.5	-0.9	-0.3	-0.3	0.1	-1.2	-1.9	-0.7	-0.1	-0.9
Pulse wave reflection index	2.3	2.8	8.2	0.8	2.8	1.0	2.9	-1.3	-0.6	0.5	1.5	0.5	2.7	1.4	1.4
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.7	-0.1	-1.6	0.9	-1.0	1.2	-0.4	0.9	-1.0	-1.1	-1.4	-0.6	-1.1
Loud music exposure frequency	0.8	0.8	2.8	-0.7	-0.0	-1.7	0.5	-0.4	1.1	-1.5	1.3	-0.6	-0.5	0.4	0.5
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	8.0	0.7	0.7	1.7	0.9	-2.8	-2.4	0.9	-1.2	-0.1	1.3	1.0	-0.0
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	5.0	1.1	0.3	-2.2	-0.7	-0.3	0.7	-1.9	1.5	1.2	0.2	0.3	0.6
Blood clot in the leg (DVT)	0.8	1.1	4.8	0.0	1.1	-1.7	-0.4	-1.1	-0.7	-2.2	-0.3	-1.3	0.2	-0.1	-0.3
Medication: Paracetamol	1.5	2.5	8.0	-0.5	-1.7	-2.8	-1.1	0.2	-0.7	-2.4	-0.8	0.2	-1.8	-1.9	-1.7
Headache pain in last month	0.5	0.9	2.7	-0.4	-0.8	-1.5	-0.5	1.5	1.6	-1.1	0.9	-0.0	-0.8	-0.9	-0.2
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	7.5	-1.0	1.8	1.3	1.2	-1.7	-0.9	0.2	-0.6	-2.7	1.5	0.9	0.3
Glaucoma (self-reported)	0.6	0.7	2.3	0.1	-1.4	0.4	-0.6	1.0	-1.1	0.9	-0.8	1.5	-0.2	-0.0	-0.5
Gout (self-reported)	0.6	0.8	2.2	0.6	1.1	-1.0	0.5	-1.3	-1.4	-1.5	-0.1	-0.6	0.2	-0.3	-0.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	3.8	1.0	0.5	-2.0	0.2	0.2	-0.7	-1.8	0.3	0.6	-0.0	-0.9	-0.1
Medication: Amlodipine	1.2	1.7	5.9	-0.3	-1.1	-1.1	-0.4	2.4	2.3	-0.1	0.8	1.1	-1.6	-1.3	0.2
Medication: Ventolin 100micrograms inhaler	0.5	0.6	2.8	-0.6	-0.9	-0.5	-0.6	-0.0	-0.5	-0.4	-0.8	0.2	-1.7	-0.6	-1.0
Birth weight	0.9	1.9	6.1	0.2	-0.4	0.6	2.4	-2.5	-2.1	0.0	-1.3	-0.7	1.0	1.5	-0.5
Chronic bronchitis/emphysema (mother)	1.1	1.2	5.3	1.3	-0.5	-2.3	-0.4	-0.4	-1.3	-2.0	-0.3	1.1	-0.1	0.2	-0.3
High blood pressure (siblings)	0.2	0.3	1.3	-0.2	0.0	-1.1	-0.3	-0.1	0.4	-1.1	-0.2	-0.5	-0.4	-0.5	0.3
Forced vital capacity (FVC), Best measure	1.5	5.7	15.8	2.3	1.9	2.1	4.0	-2.8	-2.1	0.6	0.5	-2.0	3.6	3.0	-0.1
Body fat percentage	0.2	0.7	2.3	1.2	1.5	-0.6	0.4	-0.7	0.3	-0.5	0.4	1.1	1.2	-0.7	0.7
Leg fat percentage (right)	0.2	0.8	1.9	0.9	0.8	-1.4	-0.9	0.2	0.9	-1.0	0.3	1.3	0.1	-1.4	0.4
Arm fat-free mass (right)	0.2	0.8	2.0	0.4	0.7	1.1	1.4	-1.4	-1.4	0.4	-0.3	-0.2	1.3	0.4	-0.3
Exposure to tobacco smoke outside home	1.3	1.7	3.9	0.7	1.7	-0.0	0.5	0.3	1.7	0.1	2.0	1.6	1.7	0.8	1.9
Comparative body size at age 10	1.2	3.3	7.2	-2.1	-1.0	1.7	-1.2	2.5	-0.3	2.1	-2.7	-1.0	-2.1	-2.2	-0.9
Number of full brothers	0.5	0.6	2.0	-1.4	-1.0	-0.4	-0.9	0.4	-0.8	-0.3	-0.4	0.6	-1.0	-0.7	-0.9
Worry too long after embarrassment	1.7	2.9	13.1	-1.1	-1.2	-0.3	0.9	-1.5	-2.9	-0.8	-1.5	-1.6	-1.1	0.1	-3.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	5.5	0.6	0.4	1.9	2.1	-0.4	1.4	1.8	1.2	0.7	1.6	2.4	1.1
Wheeze or whistling in the chest in last year	0.2	0.4	2.8	-0.6	1.7	0.6	0.4	-0.1	0.2	0.4	0.7	0.2	0.4	-0.1	0.4
Number of children fathered	1.1	1.3	3.7	-0.7	-1.8	-0.9	-1.9	1.1	0.6	-0.4	-0.6	-0.2	-1.7	-1.1	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.8	2.6	0.3	0.4	1.2	-0.8	1.0	-0.9	1.5	-0.4	1.6	0.1	0.0	-0.1
Age at first live birth	0.7	1.3	4.2	0.4	1.8	-0.3	2.1	-1.5	-1.1	-0.9	0.1	-0.9	1.3	0.7	0.1
Pulse wave peak to peak time	0.8	1.0	4.3	0.6	-2.1	-0.8	-1.7	-0.1	0.1	-0.5	-0.8	-0.3	-1.1	0.5	-1.0
Health satisfaction	1.0	1.4	3.5	-0.5	-0.9	0.9	-1.9	1.4	0.1	1.4	-0.8	1.3	-1.8	-1.2	0.4
Shortness of breath walking on level ground	1.1	1.3	5.7	0.3	0.1	2.3	0.1	-1.0	-0.7	2.4	-0.7	1.3	0.8	0.4	0.5
Qualifications: College or University degree	1.8	5.8	19.9	2.0	1.3	-1.2	3.3	-4.5	-2.8	-2.2	0.6	-1.6	2.4	2.8	-1.3
Eye problems/disorders: None of the above	0.5	0.6	2.5	-1.1	1.0	-0.5	1.6	-0.3	0.4	-0.8	0.8	-0.6	-0.4	0.3	0.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.7	-0.8	-1.2	-0.2	-1.3	-0.0	-0.5	-0.1	-0.3	-0.5	-1.2	-0.2	-0.6
Emphysema/chronic bronchitis	0.3	0.4	1.2	1.1	1.1	0.4	0.3	-0.1	0.8	0.3	0.6	-0.0	0.6	0.4	0.5
Medication for pain relief, constipation, heartburn	1.3	2.2	5.2	0.4	1.3	2.3	1.7	-1.4	-0.5	1.9	0.2	0.3	1.9	2.2	1.2
Neck or shoulder pain in last month	0.9	1.3	4.5	-0.5	-2.1	0.1	-1.3	2.1	1.0	0.4	-0.4	0.4	-1.1	-1.2	-0.4
Medication: Blood pressure	1.0	1.8	8.2	1.3	-1.7	-1.2	-0.8	1.3	1.3	-0.2	1.6	2.9	-0.6	0.0	0.5
Angina (self-reported)	0.5	0.7	1.7	0.4	-1.3	-0.1	-0.8	0.9	1.2	0.4	0.7	0.9	-0.7	-0.3	1.2
Migraine (self-reported)	0.3	0.4	1.4	0.4	-0.1	-0.6	0.2	1.2	0.7	-0.4	1.0	0.7	-0.3	-0.5	0.6
Medication: Ibuprofen	0.2	0.2	0.5	-0.1	-0.7	-0.2	0.2	0.1	0.5	-0.2	0.5	-0.7	0.6	0.7	-0.1
Medication: Allopurinol	2.4	3.1	8.6	0.6	0.4	-2.0	-0.1	-2.2	-2.9	-2.6	-1.9	-1.7	-1.0	-1.4	-1.9
Medication: Omeprazole	1.7	2.1	6.5	-1.7	-0.5	-1.4	-0.5	0.9	-0.1	-1.5	-1.4	-1.4	-1.9	-2.5	-1.5
Medication: Seretide 50 evohaler	0.6	0.6	1.7	-1.3	0.5	-0.5	0.1	0.1	0.7	-0.6	-0.8	-1.3	-0.9	-1.2	0.2
Mean time to correctly identify matches	1.0	2.0	6.2	1.8	2.5	-0.2	1.8	-1.7	-2.0	-1.0	0.0	-0.3	1.3	0.3	0.7
Heart disease (mother)	0.5	0.6	2.1	-0.2	0.5	1.0	1.1	0.6	0.8	0.8	-0.4	-1.4	0.3	-0.3	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.4	0.4	1.1	-0.5	-1.4	1.0	1.5	-0.0	0.8	1.0	-0.0	-0.5	1.0
Whole body fat mass	0.2	0.9	2.6	1.4	1.6	-0.1	1.2	-1.1	-0.0	-0.3	0.4	0.9	1.6	-0.2	0.5
Leg fat mass (right)	0.2	0.7	2.3	1.5	1.2	-0.1	0.5	-1.0	0.2	-0.3	0.4	1.1	1.3	-0.2	0.5
Arm predicted mass (right)	0.2	1.1	3.3	0.4	0.8	1.0	1.5	-1.8	-1.8	0.2	-0.5	-0.4	1.3	0.5	-0.6
Pulse rate, automated reading	1.3	4.2	15.5	-0.8	-1.3	0.4	-3.9	-1.5	-2.8	0.4	-2.7	0.4	-2.2	-2.7	-1.7
Alcohol intake frequency.	1.1	2.5	9.0	0.7	1.2	-1.8	-0.0	2.0	3.0	-1.5	2.8	0.1	-0.2	-0.3	1.0
Comparative height size at age 10	0.2	1.1	3.9	-0.1	2.0	0.5	1.9	-0.7	-1.1	-0.2	-0.4	-1.3	1.3	0.2	-0.1
Number of full sisters	0.7	0.9	2.4	-0.0	0.0	-0.7	-0.1	-1.5	-1.4	-1.0	-1.2	-0.1	-0.5	-0.8	-1.4
Suffer from ‘nerves’	0.3	0.4	2.2	0.0	0.4	0.1	1.5	-0.7	0.2	-0.0	0.6	0.6	1.1	0.7	0.3
Overall health rating	0.7	1.5	3.7	-0.9	-1.7	-1.1	-1.3	1.1	1.2	-0.4	-0.5	1.0	-1.9	-1.8	-0.7
Chest pain or discomfort	0.5	0.7	3.5	1.4	-0.0	-1.0	-1.2	-0.3	0.1	-0.4	0.4	1.9	-0.1	-0.5	0.0
Had major operations	1.4	1.6	3.4	1.2	0.4	1.3	0.3	0.5	1.7	1.5	1.3	1.3	1.6	1.1	1.9
Age at last live birth	0.5	0.7	2.3	-0.8	0.5	0.1	1.4	-1.2	-1.5	-0.3	-0.1	-0.8	0.5	0.5	-0.5
Family relationship satisfaction	1.3	1.6	4.5	-1.5	-0.4	1.0	-2.1	2.1	0.0	1.3	-1.0	0.0	-1.7	-1.3	-0.3
Leg pain on walking	0.7	0.8	2.1	0.3	-0.9	1.1	-1.3	1.1	1.4	1.4	-0.2	-0.3	-1.0	0.1	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.9	0.1	0.7	-0.6	-0.9	-0.0	0.8	-0.2	0.6	1.0	0.1	-0.1	0.6
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.2	-0.4	-0.7	0.0	-0.7	0.9	-0.1	-0.0	-0.9	-0.4	-0.7	-1.1	-0.9
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.4	1.4	0.5	-0.1	-1.1	-1.1	-0.4	0.2	0.5	0.7	0.7	1.5	0.1
Medication: Aspirin	0.4	0.5	1.6	0.2	-0.5	0.1	0.0	0.8	1.3	0.4	1.2	0.9	-0.6	-0.0	0.8
Supplements: Vitamin C	1.0	1.1	3.0	0.3	-0.3	1.7	1.3	-0.5	0.6	1.1	0.4	-1.5	1.3	1.7	0.2
Knee pain experienced in last month	1.8	2.8	6.0	-1.4	0.6	-2.1	-2.3	2.2	1.4	-1.7	0.5	0.2	-2.2	-2.5	-0.6
Hypertension (Self-reported)	0.7	2.1	3.9	-0.2	-2.0	-1.9	-2.0	1.9	1.7	-0.9	1.0	1.9	-1.0	-0.3	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	5.6	-0.2	0.2	-2.1	-1.7	1.5	0.2	-2.3	-0.3	-0.9	-1.4	-2.4	-1.7
Illnesses of father: Heart disease	1.7	2.3	8.3	0.5	1.0	0.2	1.4	1.7	2.4	0.3	2.9	1.4	1.6	1.0	1.6
Illnesses of siblings: Diabetes	0.4	0.4	1.4	-0.5	1.2	-0.4	-0.4	0.2	-0.4	-0.8	-0.8	-0.5	-0.6	-1.1	-0.5
Smoking status: Previous	0.2	0.3	2.3	1.0	-1.5	0.2	-0.4	0.1	-0.1	0.0	0.0	-0.5	0.2	0.5	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	10.8	-0.1	1.4	-0.2	3.3	-1.7	-0.9	-1.0	0.6	-1.1	2.1	0.9	-0.5
Whole body fat-free mass	0.3	1.7	6.5	0.7	1.1	1.6	2.5	-1.5	-1.2	0.7	0.1	-0.4	2.0	1.3	-0.2
Leg fat-free mass (right)	0.4	2.2	9.1	0.8	0.9	1.9	3.0	-1.4	-0.8	1.0	0.3	-0.2	2.4	1.6	0.2
Arm fat percentage (left)	0.3	1.1	3.3	1.5	1.4	0.1	0.7	-0.6	0.6	0.3	0.8	1.8	1.5	0.0	1.3
Average weekly red wine intake	0.2	0.4	1.2	-0.3	-1.1	0.3	0.3	-0.3	-0.7	0.3	-0.5	-0.3	-0.3	0.8	-1.0
Handedness (chirality/laterality): Left-handed	0.7	0.9	4.3	-1.0	-0.3	0.4	0.1	1.2	2.1	0.6	0.9	0.8	0.1	-0.4	1.2
Mood swings	1.4	2.5	9.9	-2.8	-0.0	-0.2	-0.9	3.2	1.8	0.3	-0.3	-0.3	-1.9	-2.0	-0.4
Loneliness, isolation	0.4	0.6	1.9	-0.8	1.0	0.7	0.2	0.2	0.6	1.1	0.7	1.4	0.1	0.3	0.8
Long-standing illness, disability or infirmity	0.8	1.2	2.9	0.9	-1.5	-1.1	-0.4	1.7	0.9	-0.6	0.2	1.0	-1.2	-1.7	-0.2
Ever had bowel cancer screening	1.7	1.9	6.3	-0.9	-1.5	0.7	-2.5	1.4	0.1	1.1	-1.3	-0.1	-2.5	-1.6	-0.1
Diabetes diagnosed by doctor	0.5	0.9	2.7	1.0	1.2	-0.7	-0.0	-0.2	0.2	-0.8	1.0	1.6	1.6	0.1	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	7.6	-1.2	-1.4	1.0	-0.2	2.2	2.8	1.4	1.6	0.2	-0.3	0.7	0.8
Friendships satisfaction	0.5	0.6	1.6	-0.9	-1.2	0.5	-0.6	0.9	0.2	0.6	-0.7	-0.9	-1.3	-0.1	-0.6
Qualifications: nursing, teaching	0.5	0.8	2.8	1.5	0.4	-0.1	1.1	-1.7	-0.7	-0.5	0.1	-0.5	1.2	1.0	-0.1
Commuting to job workplace: Walk	0.4	0.4	1.7	-0.2	-1.3	-0.2	0.8	0.3	-0.7	-0.2	-0.8	-0.9	-0.6	-0.1	-0.6
Eye problems/disorders: Cataract	0.6	0.6	3.3	1.0	0.4	0.9	-1.8	-0.3	0.6	1.0	-0.4	0.4	-0.2	-0.5	0.6
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.2	0.4	-0.3	1.5	0.9	0.2	0.3	1.5	0.6	1.4	1.5	0.7	1.0
Medication for cholesterol	1.0	1.4	4.5	1.1	0.9	1.1	2.1	-1.5	-2.0	0.1	-0.2	-1.2	0.9	0.8	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.6	-0.6	-0.5	0.1	-0.2	0.5	0.1	0.2	-0.5	-0.1	-0.8	-0.2	-0.7
Back pain experienced in last month	2.4	3.5	12.5	-0.9	-1.6	0.4	-2.2	3.5	3.4	1.0	0.1	0.7	-1.5	-2.1	1.1
Mineral and other dietary supplements	1.0	1.3	4.5	0.2	0.8	0.5	2.1	-1.5	-1.5	-0.1	-0.1	-0.6	1.8	0.9	-1.3
Breast cancer (self-reported)	1.6	1.9	6.5	-1.7	-2.5	0.3	-1.3	1.0	-0.5	0.4	-1.4	-1.3	-1.9	-0.4	-1.6
Asthma (self-reported)	0.2	0.5	1.0	0.9	0.5	0.6	0.6	-1.0	-0.6	0.4	0.3	1.0	0.9	0.6	0.6
Osteoporosis (self-reported)	0.5	0.6	1.7	0.2	-0.4	1.0	-1.0	0.3	0.1	0.9	-1.0	-0.6	-0.8	-1.3	0.4
Osteoarthritis (self-reported)	2.2	2.8	8.0	-0.6	-1.3	-1.7	-1.2	0.5	-1.3	-1.3	-2.2	-0.4	-2.4	-2.8	-2.4
Medication: Aspirin	0.3	0.4	1.5	0.2	-0.4	-0.5	0.4	0.5	0.8	-0.3	1.2	1.0	-0.5	-0.2	0.3
Medication: Gliclazide	0.6	0.7	2.1	-0.1	-0.5	-0.3	-1.3	1.2	-0.3	-0.1	-1.1	0.2	-1.5	-1.0	-0.8
Illnesses of father: None of the above (group 1)	1.3	1.6	4.1	-1.0	-1.0	0.6	-1.9	-0.5	-1.5	0.7	-2.0	-1.1	-1.4	-1.0	-1.2
Smoking status: Current	0.3	0.4	1.2	-0.4	-0.3	1.0	-0.8	-0.2	-0.7	1.1	-0.8	0.9	0.2	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.3	10.3	2.4	0.5	1.5	1.8	-2.5	-2.2	0.7	0.1	0.9	3.2	2.3	0.5
Whole body water mass	0.3	1.8	6.2	0.7	1.0	1.7	2.5	-1.6	-1.3	0.7	0.0	-0.3	2.0	1.3	-0.2
Leg predicted mass (right)	0.4	2.1	8.9	0.7	0.9	1.9	3.0	-1.3	-0.8	1.0	0.3	-0.3	2.4	1.5	0.1
Arm fat mass (left)	0.3	1.2	3.4	1.5	1.4	0.5	1.3	-1.3	-0.3	0.3	0.5	1.3	1.8	0.4	0.6
Number of self-reported non-cancer illnesses	2.3	4.0	7.6	-1.3	-2.2	-2.4	-2.1	2.4	1.1	-1.8	-0.8	-0.0	-2.8	-2.7	-2.3
Average weekly champagne plus white wine intake	1.3	1.8	5.7	0.9	0.8	0.9	2.1	-1.9	-0.8	0.5	0.7	-0.0	1.7	2.4	1.1
Miserableness	0.7	1.2	2.9	-1.7	0.1	1.4	-0.5	1.7	-0.0	1.5	-1.0	0.4	-1.0	-1.3	-0.5
Guilty feelings	1.0	1.5	4.7	0.4	-1.5	1.4	0.7	-0.9	-2.2	1.3	0.2	0.8	-0.2	1.5	-1.7
Wears glasses or contact lenses	0.6	0.7	2.5	-0.4	1.2	0.2	0.3	1.5	0.1	0.2	-0.5	-0.3	-0.9	-1.6	-0.5
Ever taken oral contraceptive pill	5.2	5.8	11.9	3.4	0.7	2.9	2.0	-1.7	0.7	2.4	2.7	1.9	3.0	3.5	2.1
Hearing aid user	1.2	1.3	4.1	2.0	0.7	0.6	0.9	0.2	0.4	0.7	1.2	1.9	1.4	0.4	1.5
Mother’s age at death	0.2	0.3	1.4	0.3	-0.1	0.2	-0.6	-0.9	0.2	-0.3	-0.4	-1.2	-0.1	-0.4	-0.1
Financial situation satisfaction	0.5	0.6	2.8	0.8	-1.1	0.2	-0.6	-0.2	-0.2	0.1	0.9	0.6	0.4	1.7	-0.5
Tinnitus: Yes, now most or all of the time	1.3	1.5	4.3	1.3	-0.6	0.3	1.8	-1.5	-0.8	-0.1	0.9	0.2	1.8	2.1	1.2
Commuting to job workplace: Public transport	0.6	0.7	2.4	0.0	-0.2	0.2	0.6	-0.2	0.9	0.3	1.1	0.3	1.4	1.6	0.8
Eye problems/disorders: Glaucoma	1.1	1.4	7.5	-0.5	-2.7	0.6	-1.0	1.0	-0.9	1.1	-1.3	0.8	-0.9	-0.1	-1.0
Medication: Blood pressure	0.8	1.6	3.8	-1.2	-1.1	-1.6	-1.7	1.7	1.9	-1.0	0.1	0.1	-1.2	-1.1	-0.7
Pain type(s) experienced in last month: Hip pain	1.4	1.7	6.6	-0.0	-1.8	-0.5	-1.6	-1.0	-1.8	-0.6	-1.6	-0.9	-0.8	0.2	-2.6
Supplements: Fish oil (including cod liver oil)	1.0	1.2	3.8	0.2	-0.1	-1.7	-0.7	1.4	1.9	-1.2	0.7	0.1	-1.5	-0.8	1.0
High cholesterol (Self-reported)	1.4	2.5	5.2	-1.1	-1.2	-2.2	-2.3	0.7	-0.9	-1.7	-1.1	1.0	-2.0	-2.2	-1.6
Medication: Bendroflumethiazide	0.4	0.6	2.5	-1.6	-0.6	0.0	-0.4	1.0	1.1	0.5	-0.1	0.5	-0.9	-0.9	-0.1
Medication: Paracetamol	1.3	2.0	7.6	-0.6	-1.1	-2.8	-0.5	-0.1	-0.7	-2.5	-0.9	0.1	-1.5	-1.9	-1.4
Medication: Lisinopril	0.6	0.8	3.8	1.1	0.7	-0.1	0.4	0.3	1.0	0.1	1.9	1.4	0.6	0.6	0.4
Medication: Atorvastatin	0.4	0.4	1.2	1.0	-0.4	1.1	-0.9	-0.5	-0.1	1.0	-0.2	0.3	0.5	0.7	-0.0
Illnesses of father: High blood pressure	0.5	0.7	2.6	0.4	-0.4	-0.3	-0.7	1.1	1.1	0.1	1.3	1.6	-0.6	-0.2	0.3
Alcohol drinker status: Never	1.4	1.7	6.0	1.0	-0.1	-2.5	-0.3	1.1	1.1	-1.5	1.6	2.4	0.4	-0.1	0.1
Ever smoked	0.6	1.1	3.5	1.9	-1.5	0.1	-1.1	-1.5	-1.4	-0.0	-0.3	0.5	0.6	1.1	0.1
Basal metabolic rate	0.3	1.7	6.2	1.0	1.2	1.5	2.5	-1.4	-1.0	0.7	0.2	-0.1	2.1	1.2	-0.1
Leg fat percentage (left)	0.2	0.6	1.8	0.8	0.6	-0.9	-0.6	0.5	1.2	-0.6	0.3	1.3	0.4	-1.1	0.7
Arm fat-free mass (left)	0.3	1.6	4.0	1.1	1.3	1.1	2.0	-1.9	-1.7	0.1	-0.1	-0.2	1.9	0.8	-0.5
Number of operations (self-reported)	1.2	1.8	5.0	-0.6	-1.9	0.0	-1.6	0.9	-0.4	0.4	-2.2	-0.1	-1.7	-1.8	-1.4
Average weekly beer plus cider intake	0.8	1.2	3.0	-1.4	1.2	-1.2	0.7	-0.4	-1.0	-1.6	-0.7	-0.3	-0.6	-1.7	-0.8
Irritability	0.6	1.0	8.0	1.1	0.0	0.5	0.1	-0.5	-0.3	0.9	1.1	2.8	0.2	0.1	0.2
Risk taking	0.3	0.4	1.4	1.2	0.8	0.8	-0.4	0.0	-0.5	0.8	0.0	0.2	0.9	0.6	0.6
Ever had prostate specific antigen (PSA) test	1.2	1.4	6.3	-1.3	-0.5	0.4	-0.5	2.3	2.5	0.9	0.8	0.2	-0.6	0.1	1.0
Fractured/broken bones in last 5 years	0.5	0.6	1.7	0.3	0.1	1.3	-0.9	0.1	0.2	1.0	-1.2	-0.8	-0.2	-0.9	1.0
Age started oral contraceptive pill	0.6	0.7	2.4	-0.4	0.4	1.2	-0.2	1.1	1.5	1.1	-0.1	-0.7	-0.1	0.0	1.1
Diastolic blood pressure, automated reading	0.1	0.3	0.8	-0.9	0.3	-0.8	-0.8	-0.1	0.4	-0.6	-0.1	-0.3	-0.6	-0.5	-0.0
Ever depressed for a whole week	0.8	1.0	3.7	-0.1	-1.8	1.4	-0.5	1.9	0.7	1.3	0.0	-0.3	-0.7	0.5	-0.5
Unable to work because of sickness or disability	0.8	1.0	3.2	0.4	0.9	-0.8	0.8	1.0	1.3	-0.4	1.4	1.8	0.8	-0.4	1.0
Commuting to job workplace: Cycle	0.2	0.3	0.7	0.5	-0.3	-0.8	0.0	0.6	-0.5	-0.7	0.8	0.2	0.1	0.8	-0.1
Myopia	1.6	2.3	4.9	-0.9	-1.7	-1.9	-1.2	-0.5	-1.8	-1.8	-1.4	-1.0	-2.2	-0.8	-2.0
Vascular/heart problems diagnosed by doctor	0.7	1.9	4.7	0.1	1.5	2.2	2.1	-1.4	-1.5	1.2	-0.8	-1.7	1.3	0.9	-0.1
Cholesterol lowering medication	1.6	2.3	4.7	-1.8	-1.4	-2.2	-2.1	1.1	-0.5	-1.5	-1.0	0.8	-1.6	-1.8	-1.6
Medication: Omeprazole (e.g. Zanprol)	2.6	3.2	11.2	-1.8	-1.0	-1.5	-1.5	1.5	0.2	-1.4	-1.5	-1.1	-2.9	-3.3	-1.6
Pain experienced in last month	1.6	2.6	7.3	1.0	1.3	1.7	1.9	-2.3	-1.4	1.4	0.7	0.7	2.0	2.7	0.8
Supplements: Calcium	0.1	0.1	0.5	-0.0	-0.7	0.3	-0.6	0.1	0.1	0.2	0.0	0.2	-0.3	0.0	0.6
Basal cell carcinoma (self-reported)	0.3	0.4	1.1	-0.1	-1.1	0.6	-0.5	0.8	-0.5	0.9	-0.3	0.3	-0.7	-0.1	-0.7
Heart attack/myocardial infarction (self-reported)	0.6	0.8	3.2	1.6	-0.9	-0.7	0.1	1.0	0.6	-0.1	0.8	1.8	-0.2	-0.0	0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.0	0.1	1.2	-1.1	0.0	-1.4	-0.8	-1.7	-0.2	-1.4	0.4	0.3	-0.2
Heart disease (siblings)	0.3	0.4	2.0	0.3	-0.3	0.2	0.2	0.8	0.1	0.5	0.6	1.4	0.2	0.4	0.7
Alcohol drinker status: Previous	0.8	0.9	5.8	-0.4	1.0	-0.2	0.7	0.8	1.3	-0.7	0.3	-2.4	-0.3	-0.0	-0.4
Pack years of smoking	1.0	1.5	3.8	-0.8	-1.1	-2.0	-0.8	-0.0	0.9	-1.9	-0.5	-1.6	-0.9	-0.7	-1.7
Impedance of whole body	0.1	0.7	2.2	-1.5	0.7	-1.2	-0.9	0.3	0.4	-1.0	-0.2	-1.1	-0.8	-0.9	0.2
Leg fat mass (left)	0.2	0.7	2.2	1.5	1.2	0.2	0.5	-0.7	0.3	0.1	0.4	1.2	1.4	-0.1	0.7
Arm predicted mass (left)	0.3	1.6	4.0	1.0	1.1	1.0	1.9	-1.9	-1.7	0.1	-0.0	-0.2	2.0	1.1	-0.5