[Hub]/) : Traits : Heel T-Score : ← →

chr1:88,453,303-90,928,816

Best TWAS P=2.23e-20 · Best GWAS P=1.69e-23 conditioned to 2.02e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CCBL2	0.58	0.68	lasso	7	0.69	1.4e-117	7.6	-7.9	2.6e-15	-0.65	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	CCBL2	0.26	0.21	enet	15	0.23	1.2e-18	7.7	-7.3	3.6e-13	-0.61	1.00	0.00	FALSE
3	GTEx	Adipose Visceral Omentum	PKN2	0.09	0.04	enet	8	0.05	1.2e-03	7.6	6.9	4.8e-12	0.67	0.34	0.30	FALSE
4	GTEx	Adipose Visceral Omentum	CCBL2	0.21	0.10	enet	7	0.15	5.2e-08	7.7	-7.9	3.4e-15	-0.66	0.90	0.08	FALSE
5	GTEx	Adrenal Gland	CCBL2	0.18	0.13	enet	46	0.14	1.4e-05	8.6	-6.1	8.9e-10	-0.52	0.16	0.78	FALSE
6	GTEx	Artery Aorta	CCBL2	0.29	0.20	enet	24	0.24	1.5e-13	7.7	-8.1	8.3e-16	-0.59	0.98	0.02	FALSE
7	GTEx	Artery Coronary	CCBL2	0.29	0.19	enet	5	0.14	1.6e-05	8.1	-8.0	1.5e-15	-0.61	0.76	0.03	FALSE
8	GTEx	Artery Tibial	CCBL2	0.30	0.24	lasso	8	0.29	4.9e-23	7.6	-7.7	1.1e-14	-0.67	1.00	0.00	FALSE
9	GTEx	Brain Caudate basal ganglia	CCBL2	0.27	0.21	enet	30	0.29	7.0e-09	7.6	-6.6	3.5e-11	-0.57	0.68	0.28	FALSE
10	GTEx	Brain Cerebellar Hemisphere	CCBL2	0.31	0.18	lasso	5	0.23	1.7e-06	7.6	-9.2	2.2e-20	-0.85	0.03	0.97	TRUE
11	GTEx	Brain Cerebellum	CCBL2	0.39	0.30	enet	23	0.33	1.7e-10	7.7	-7.1	1.1e-12	-0.57	0.74	0.24	FALSE
12	GTEx	Brain Cortex	CCBL2	0.59	0.39	enet	13	0.37	3.0e-11	7.6	-8.0	9.8e-16	-0.68	0.88	0.12	FALSE
13	GTEx	Brain Frontal Cortex BA9	CCBL2	0.47	0.38	enet	25	0.48	1.5e-14	7.7	-7.5	9.6e-14	-0.65	0.78	0.22	FALSE
14	GTEx	Brain Hippocampus	CCBL2	0.39	0.27	lasso	5	0.13	5.1e-04	7.7	7.0	3.7e-12	0.55	0.20	0.30	FALSE
15	GTEx	Brain Hypothalamus	CCBL2	0.34	0.00	enet	34	0.13	6.4e-04	7.7	-6.4	1.3e-10	-0.42	0.21	0.28	FALSE
16	GTEx	Brain Nucleus accumbens basal ganglia	CCBL2	0.38	0.44	enet	20	0.32	2.1e-09	7.4	-8.4	4.1e-17	-0.70	0.68	0.31	FALSE
17	GTEx	Brain Putamen basal ganglia	CCBL2	0.35	0.26	enet	21	0.25	1.2e-06	7.6	-7.8	8.9e-15	-0.57	0.33	0.52	FALSE
18	GTEx	Breast Mammary Tissue	CCBL2	0.15	0.11	lasso	5	0.09	1.8e-05	7.6	-7.7	1.6e-14	-0.59	0.77	0.19	FALSE
19	GTEx	Breast Mammary Tissue (Male)	CCBL2	0.14	0.03	lasso	2	0.02	8.8e-02	7.6	-7.6	2.1e-14	-0.59	0.06	0.18	FALSE
20	GTEx	Cells Transformed fibroblasts	CCBL2	0.65	0.61	enet	32	0.67	6.1e-67	7.6	-7.7	1.1e-14	-0.62	1.00	0.00	FALSE
21	GTEx	Colon Sigmoid	CCBL2	0.22	0.12	enet	4	0.09	5.2e-04	7.7	-7.5	4.2e-14	-0.58	0.41	0.24	FALSE
22	GTEx	Colon Transverse	PKN2	0.23	0.08	lasso	7	0.08	1.0e-04	-4.3	-6.6	4.2e-11	-0.63	0.31	0.61	FALSE
23	GTEx	Colon Transverse	CCBL2	0.30	0.19	lasso	8	0.26	1.2e-12	7.6	-8.0	1.3e-15	-0.69	0.99	0.01	FALSE
24	GTEx	Esophagus Mucosa	CCBL2	0.35	0.19	enet	27	0.30	2.7e-20	7.6	-5.9	3.2e-09	-0.56	0.97	0.03	FALSE
25	GTEx	Esophagus Muscularis	CCBL2	0.25	0.29	enet	18	0.28	1.6e-17	7.7	-8.0	1.5e-15	-0.66	1.00	0.00	FALSE
26	GTEx	Heart Atrial Appendage	CCBL2	0.30	0.20	enet	11	0.15	3.4e-07	7.7	-7.8	9.1e-15	-0.61	0.99	0.00	FALSE
27	GTEx	Lung	CCBL2	0.15	0.13	enet	13	0.17	4.8e-13	7.7	-7.4	1.9e-13	-0.58	1.00	0.00	FALSE
28	GTEx	Muscle Skeletal	CCBL2	0.12	0.15	enet	9	0.16	5.4e-15	7.7	-7.6	2.6e-14	-0.59	1.00	0.00	FALSE
29	GTEx	Nerve Tibial	CCBL2	0.42	0.33	enet	38	0.38	3.4e-28	7.6	-7.9	3.2e-15	-0.59	1.00	0.00	FALSE
30	GTEx	Pancreas	CCBL2	0.26	0.21	lasso	4	0.23	5.3e-10	7.6	-6.6	4.9e-11	-0.68	0.20	0.78	FALSE
31	GTEx	Pituitary	CCBL2	0.45	0.30	lasso	2	0.26	2.7e-07	7.6	-8.0	9.9e-16	-0.71	0.38	0.58	FALSE
32	GTEx	Skin Sun Exposed Lower leg	CCBL2	0.18	0.09	enet	12	0.17	4.0e-14	7.4	-6.6	5.2e-11	-0.57	0.98	0.02	FALSE
33	GTEx	Small Intestine Terminal Ileum	PKN2	0.26	0.34	lasso	5	0.23	7.0e-06	6.0	-6.0	2.4e-09	-0.67	0.58	0.08	FALSE
34	GTEx	Stomach	CCBL2	0.16	0.08	lasso	4	0.15	9.0e-08	7.6	-8.7	2.4e-18	-0.71	0.58	0.37	FALSE
35	GTEx	Testis	CCBL2	0.47	0.56	lasso	5	0.57	1.2e-30	7.6	-7.6	2.2e-14	-0.59	1.00	0.00	FALSE
36	GTEx	Thyroid	CCBL2	0.22	0.15	enet	22	0.22	9.8e-17	7.6	-7.0	3.3e-12	-0.67	0.97	0.03	FALSE
37	GTEx	Thyroid	RBMXL1	0.09	0.02	enet	19	0.04	2.7e-04	2.3	-5.6	2.2e-08	-0.59	0.06	0.83	FALSE
38	GTEx	Whole Blood	CCBL2	0.08	0.07	lasso	3	0.06	3.1e-06	7.6	-7.3	3.2e-13	-0.53	0.82	0.14	FALSE
39	METSIM	Adipose	CCBL2	0.27	0.14	lasso	6	0.18	6.4e-27	7.7	-8.5	1.8e-17	-0.71	1.00	0.00	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	CCBL2	0.43	0.56	enet	31	0.56	1.1e-87	7.7	-8.2	2.1e-16	-0.67	1.00	0.00	FALSE
41	YFS	Blood	GTF2B	0.01	0.00	lasso	3	0.01	2.3e-04	9.7	8.1	4.1e-16	0.82	0.11	0.64	FALSE
42	YFS	Blood	LRRC8C	0.36	0.51	enet	41	0.55	3.6e-218	4.8	-5.7	9.7e-09	0.01	0.29	0.70	FALSE
43	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CCBL2	0.14	0.09	enet	12	0.10	1.5e-08	7.7	-6.5	9.7e-11	-0.49	0.92	0.07	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCBL2	0.20	0.36	lasso	5	0.36	1.7e-78	7.7	-7.7	1.8e-14	-0.58	0.94	0.06	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	PKN2	0.02	0.01	enet	5	0.01	2.3e-03	7.5	7.5	6.5e-14	0.86	0.02	0.76	FALSE
46	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CCBL2	0.09	0.08	blup	61	0.07	3.6e-04	7.6	-6.0	2.1e-09	-0.46	0.38	0.46	FALSE
47	The Cancer Genome Atlas	Colon Adenocarcinoma	CCBL2	0.23	0.28	lasso	3	0.26	3.9e-15	7.6	-7.2	7.1e-13	-0.52	0.94	0.06	FALSE
48	The Cancer Genome Atlas	Glioblastoma Multiforme	CCBL2	0.36	0.32	enet	37	0.33	6.4e-11	7.7	-7.8	6.2e-15	-0.68	0.04	0.96	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CCBL2	0.07	0.06	lasso	2	0.05	1.2e-06	7.6	-6.6	4.2e-11	-0.53	0.44	0.53	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCBL2	0.37	0.48	enet	20	0.50	1.5e-63	7.7	-7.3	2.3e-13	-0.55	0.94	0.06	FALSE
51	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CCBL2	0.28	0.42	enet	15	0.40	1.5e-24	7.6	-7.5	4.8e-14	-0.60	0.95	0.05	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCBL2	0.28	0.32	enet	24	0.31	2.5e-35	7.6	-8.0	1.6e-15	-0.62	0.92	0.08	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	PKN2	0.05	0.01	enet	8	0.02	1.6e-03	8.5	7.7	1.0e-14	0.79	0.10	0.83	FALSE
54	The Cancer Genome Atlas	Lung Adenocarcinoma	CCBL2	0.09	0.12	enet	10	0.11	8.7e-13	7.6	-7.1	1.7e-12	-0.55	0.90	0.10	FALSE
55	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CCBL2	0.10	0.07	enet	12	0.08	2.0e-09	7.4	-6.0	1.5e-09	-0.55	0.89	0.11	FALSE
56	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CCBL2	0.14	0.13	enet	15	0.12	9.7e-09	7.7	-6.4	1.3e-10	-0.40	0.92	0.08	FALSE
57	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CCBL2	0.15	0.18	lasso	2	0.16	3.5e-07	8.1	-8.1	5.2e-16	-0.63	0.43	0.54	FALSE
58	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CCBL2	0.37	0.47	enet	19	0.46	3.1e-20	7.4	-7.8	6.7e-15	-0.62	0.94	0.06	FALSE
59	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCBL2	0.20	0.34	lasso	2	0.35	9.5e-38	7.4	-7.5	4.9e-14	-0.60	0.95	0.05	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	LRRC8C	0.04	0.00	blup	71	0.01	1.0e-02	2.5	5.5	4.0e-08	-0.08	0.02	0.79	FALSE
61	The Cancer Genome Atlas	Rectum Adenocarcinoma	CCBL2	0.35	0.27	lasso	6	0.25	1.7e-06	7.4	-7.8	5.8e-15	-0.62	0.15	0.81	FALSE
62	The Cancer Genome Atlas	Soft Tissue Sarcoma	CCBL2	0.28	0.32	enet	21	0.32	8.7e-20	7.6	-7.7	2.1e-14	-0.60	0.87	0.13	FALSE
63	The Cancer Genome Atlas	Skin Cutaneous Melanoma	CCBL2	0.24	0.20	enet	12	0.17	2.7e-05	7.6	-7.5	5.7e-14	-0.56	0.31	0.18	FALSE
64	The Cancer Genome Atlas	Stomach Adenocarcinoma	CCBL2	0.11	0.13	enet	14	0.11	1.7e-08	7.7	-7.1	1.0e-12	-0.56	0.80	0.20	FALSE
65	The Cancer Genome Atlas	Stomach Adenocarcinoma	LRRC8C	0.09	0.01	blup	71	0.05	9.6e-05	4.8	5.8	5.8e-09	-0.02	0.07	0.31	TRUE
66	The Cancer Genome Atlas	Thyroid Carcinoma	CCBL2	0.45	0.64	enet	13	0.66	1.4e-86	7.6	-7.8	9.0e-15	-0.59	0.94	0.06	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	LRRC8C	0.04	0.03	blup	71	0.03	3.7e-04	4.5	5.6	1.8e-08	-0.06	0.17	0.52	FALSE
68	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	CCBL2	0.20	0.22	enet	16	0.18	8.6e-06	7.7	-6.8	1.1e-11	-0.46	0.38	0.52	FALSE