Best TWAS P=2.96e-17 · Best GWAS P=1.19e-20 conditioned to 0.00156
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ABCB8 | 0.26 | 0.14 | bslmm | 554 | 0.18 | 1.4e-21 | 4.2 | -5.9 | 4.1e-09 | 0.47 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | AGAP3 | 0.14 | 0.01 | enet | 54 | 0.07 | 4.5e-06 | -7.7 | 7.1 | 1.5e-12 | -0.36 | 0.10 | 0.43 | TRUE |
| 3 | GTEx | Adipose Subcutaneous | WDR86 | 0.13 | 0.10 | lasso | 4 | 0.08 | 4.6e-07 | -6.2 | -6.5 | 5.7e-11 | -0.05 | 1.00 | 0.00 | TRUE |
| 4 | GTEx | Colon Transverse | ABCB8 | 0.17 | 0.12 | lasso | 2 | 0.07 | 4.8e-04 | -7.5 | -7.8 | 4.6e-15 | 0.89 | 0.04 | 0.90 | FALSE |
| 5 | GTEx | Esophagus Mucosa | SLC4A2 | 0.11 | 0.03 | enet | 8 | 0.06 | 5.1e-05 | -8.4 | -6.0 | 1.8e-09 | 0.83 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Esophagus Mucosa | ABCB8 | 0.15 | 0.10 | lasso | 6 | 0.07 | 1.0e-05 | -6.2 | -5.7 | 1.4e-08 | 0.68 | 0.05 | 0.94 | FALSE |
| 7 | GTEx | Heart Atrial Appendage | ABCB8 | 0.13 | -0.01 | lasso | 4 | 0.02 | 4.6e-02 | 3.4 | -8.1 | 6.8e-16 | 0.66 | 0.02 | 0.87 | FALSE |
| 8 | GTEx | Muscle Skeletal | AGAP3 | 0.10 | 0.04 | lasso | 5 | 0.03 | 8.5e-04 | -8.2 | 8.4 | 3.0e-17 | -0.88 | 0.06 | 0.90 | TRUE |
| 9 | GTEx | Nerve Tibial | ABCF2 | 0.21 | 0.14 | lasso | 5 | 0.14 | 3.5e-10 | 6.1 | 5.8 | 7.3e-09 | -0.07 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Nerve Tibial | ABCB8 | 0.23 | 0.02 | enet | 17 | 0.10 | 8.7e-08 | -9.3 | -6.2 | 5.8e-10 | 0.61 | 0.00 | 1.00 | FALSE |
| 11 | GTEx | Spleen | CHPF2 | 0.46 | 0.16 | lasso | 5 | 0.25 | 4.8e-07 | 6.5 | 5.8 | 7.2e-09 | -0.09 | 0.29 | 0.04 | FALSE |
| 12 | GTEx | Thyroid | ABCF2 | 0.28 | 0.23 | lasso | 3 | 0.22 | 1.1e-16 | 6.3 | 5.8 | 4.8e-09 | -0.07 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Thyroid | SMARCD3 | 0.10 | 0.01 | lasso | 3 | 0.01 | 3.5e-02 | -7.8 | -7.4 | 1.4e-13 | 0.79 | 0.04 | 0.82 | FALSE |
| 14 | GTEx | Thyroid | ABCB8 | 0.16 | 0.12 | lasso | 5 | 0.14 | 3.2e-11 | 4.2 | -6.1 | 9.6e-10 | 0.55 | 0.77 | 0.23 | FALSE |
| 15 | GTEx | Thyroid | ASIC3 | 0.18 | 0.12 | enet | 29 | 0.12 | 1.7e-09 | -7.5 | -5.7 | 1.4e-08 | 0.73 | 0.56 | 0.44 | FALSE |
| 16 | GTEx | Whole Blood | ABCF2 | 0.17 | 0.00 | enet | 45 | 0.03 | 4.6e-04 | 6.2 | 7.8 | 5.4e-15 | -0.09 | 0.14 | 0.12 | TRUE |
| 17 | GTEx | Whole Blood | AGAP3 | 0.09 | 0.04 | lasso | 4 | 0.03 | 1.3e-03 | -7.8 | 8.0 | 9.1e-16 | -0.88 | 0.23 | 0.72 | FALSE |
| 18 | METSIM | Adipose | ABCF2 | 0.12 | 0.07 | lasso | 3 | 0.06 | 9.3e-10 | 5.3 | 5.3 | 9.0e-08 | -0.06 | 1.00 | 0.00 | FALSE |
| 19 | ROSMAP | Brain Pre-frontal Cortex | WDR86 | 0.11 | 0.07 | lasso | 2 | 0.07 | 1.2e-09 | -6.2 | -6.5 | 7.1e-11 | -0.07 | 1.00 | 0.00 | FALSE |
| 20 | YFS | Blood | ABCF2 | 0.07 | 0.05 | lasso | 2 | 0.05 | 2.9e-15 | 6.1 | 6.1 | 1.2e-09 | -0.07 | 1.00 | 0.00 | FALSE |
| 21 | YFS | Blood | SLC4A2 | 0.03 | 0.02 | lasso | 4 | 0.02 | 1.5e-07 | 4.9 | -6.8 | 8.9e-12 | 0.70 | 0.04 | 0.96 | FALSE |
| 22 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NUB1 | 0.04 | 0.00 | blup | 86 | 0.02 | 3.6e-03 | -2.9 | -5.3 | 1.4e-07 | -0.06 | 0.03 | 0.30 | FALSE |
| 23 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AGAP3 | 0.04 | 0.03 | lasso | 3 | 0.02 | 4.1e-03 | -8.4 | 8.3 | 1.1e-16 | -0.91 | 0.03 | 0.65 | FALSE |
| 24 | The Cancer Genome Atlas | Lung Adenocarcinoma | ABCB8 | 0.07 | 0.04 | enet | 11 | 0.05 | 1.3e-06 | 4.2 | -5.4 | 7.6e-08 | 0.43 | 0.18 | 0.38 | FALSE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | ABCB8 | 0.09 | 0.01 | blup | 55 | 0.07 | 4.7e-07 | 3.4 | -7.5 | 6.1e-14 | 0.55 | 0.06 | 0.92 | FALSE |