TWAS hub - SMARCD3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1400	0.0520	4.5e-03	0.091	NA	0.037	NA	0.061	2.7e-07	NA	8.8e-04	NA	2.5e-05
2	GTEx	Thyroid	0.0950	0.0390	8.0e-03	0.010	NA	0.006	NA	0.013	5.2e-02	NA	9.6e-02	NA	3.5e-02
3	YFS	Blood	0.0497	0.0141	2.5e-06	0.021	0.022	0.028	0.032	0.031	1.1e-07	5.1e-08	1.1e-09	7.2e-11	2.4e-10
4	TCGA	Thyroid Carcinoma	0.0650	0.0310	3.8e-03	0.007	0.027	0.001	NA	0.001	6.5e-02	1.1e-03	2.4e-01	NA	2.2e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Guilty feelings	4.4	6.6	8.7	2.9	2.5	2.3	2.5
Blood Red Count	4.2	40.2	106.1	-6.0	10.3	1.8	-3.9
Ovarian Cancer	3.3	4.3	7.8	-2.8	1.4	-0.6	-2.7
Mean Putamen Volume	3.1	3.6	12.8	-0.9	3.6	0.7	-0.4
Impedance of leg (right)	3.1	14.9	28.0	-4.8	-5.3	0.9	-2.8
Impedance of leg (left)	3.0	14.3	27.6	-4.8	-5.3	0.6	-2.6
Ever unenthusiastic/disinterested for a whole week	3.0	3.7	9.7	-0.2	-3.1	1.8	1.3
Illnesses of father: Heart disease	3.0	4.1	8.0	-2.0	-0.9	1.9	-2.8
Mouth/teeth dental problems: Dentures	2.8	4.8	12.8	3.6	-0.3	1.4	2.1
Leg fat-free mass (right)	2.7	14.3	27.7	4.2	5.3	0.1	3.5
Leg predicted mass (right)	2.7	14.4	27.2	4.2	5.2	0.1	3.5
Leg fat-free mass (left)	2.5	13.1	25.6	4.0	5.1	0.3	3.3
Leg predicted mass (left)	2.5	13.0	26.0	3.9	5.1	0.2	3.3
Heel bone mineral density (BMD) T-score, automated (right)	2.5	5.7	20.0	-1.1	-4.5	1.4	-0.0
Loud music exposure frequency	2.5	2.7	6.1	-0.3	-2.5	2.0	0.8
Whole body fat-free mass	2.5	14.2	29.8	4.0	5.5	-0.0	3.2
Whole body water mass	2.5	14.4	29.8	4.1	5.5	-0.2	3.3
HDL Cholesterol	2.4	4.0	8.9	-2.2	-3.0	0.2	-1.4
Impedance of whole body	2.4	12.3	30.6	-3.9	-5.5	1.4	-1.3
Trunk fat-free mass	2.3	13.1	27.6	3.9	5.2	-0.1	3.1
Trunk predicted mass	2.3	13.2	27.8	3.9	5.3	-0.1	3.1
Arm fat-free mass (right)	2.3	11.6	29.6	3.3	5.4	-0.6	2.4
Arm predicted mass (right)	2.3	11.9	27.9	3.7	5.3	-0.5	2.4
Osteoporosis (self-reported)	2.3	2.8	5.9	-2.4	1.3	1.0	-1.6
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.5	4.0	1.8	-1.6	-0.2	2.0
Basal metabolic rate	2.2	12.2	26.8	3.6	5.2	-0.0	3.0
Myopia	2.2	3.1	4.7	-1.7	-1.4	1.7	-2.2
Arm predicted mass (left)	2.2	11.2	27.2	3.4	5.2	-0.7	2.4
Chronic bronchitis/emphysema (father)	2.1	2.5	9.5	-0.2	-3.1	-0.5	-0.4
Mouth/teeth dental problems: Loose teeth	2.1	2.5	5.0	1.0	0.6	1.8	2.2
Commuting to job workplace: Cycle	2.1	2.6	4.2	2.0	2.1	1.4	0.5
Heel T-Score	2.0	16.0	54.6	-2.5	-7.4	-1.4	-1.1
Financial difficulties in last 2 years	2.0	2.7	5.7	1.8	1.2	-0.0	2.4
Angina (self-reported)	2.0	2.6	5.2	-1.5	0.6	1.6	-2.3
Migraine (self-reported)	2.0	2.5	4.8	0.4	1.3	1.8	2.2
Mean time to correctly identify matches	2.0	3.7	8.2	-1.5	-1.9	2.9	-1.0
Arm fat-free mass (left)	2.0	9.9	23.4	3.2	4.8	-0.4	2.4
Reaction Time	1.9	3.6	7.4	-1.8	-1.5	2.7	-1.3
Ever used hormone-replacement therapy (HRT)	1.9	2.4	2.8	-1.6	-1.2	1.7	-1.7
Medication: Ventolin 100micrograms inhaler	1.9	2.4	5.2	1.0	1.9	-2.3	-0.1
Eye problems/disorders: None of the above	1.9	2.2	6.9	-0.9	-0.1	-2.6	-1.0
Impedance of arm (right)	1.8	8.2	24.0	-2.4	-4.9	1.7	-0.2
Impedance of arm (left)	1.8	8.4	23.9	-2.4	-4.9	2.0	-0.2
Ever highly irritable/argumentative for 2 days	1.8	2.2	4.2	1.1	1.8	-0.4	2.0
Angina	1.7	2.3	4.4	-1.5	0.4	1.5	-2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	5.1	2.3	1.0	1.4	1.1
Mouth/teeth dental problems	1.7	2.6	3.9	-2.0	-1.1	-1.7	-1.5
Medication: Atorvastatin	1.7	2.1	3.0	-1.5	-1.3	-1.2	-1.7
Townsend deprivation index at recruitment	1.6	2.3	4.7	0.6	-2.2	1.8	0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.6	13.3	-0.5	-3.6	1.0	0.1
Peak expiratory flow (PEF)	1.6	3.8	6.0	-2.4	2.5	1.4	-1.2
Shortness of breath walking on level ground	1.6	1.9	4.6	0.6	-0.3	-2.1	1.6
Number of full sisters	1.6	1.9	4.1	1.4	-2.0	1.2	0.5
Fractured/broken bones in last 5 years	1.6	2.1	7.9	-0.7	2.8	-0.1	0.1
Relative age of first facial hair	1.5	3.2	6.2	1.2	2.5	-0.2	2.2
Hair/balding pattern: Pattern 2	1.5	1.9	6.2	0.1	0.3	1.2	2.5
Number of live births	1.5	2.1	5.7	0.4	0.5	2.4	1.5
Number of full brothers	1.5	1.9	4.8	-0.3	-1.6	2.2	0.2
Health satisfaction	1.5	1.9	5.2	-1.1	1.0	-2.3	-0.5
Qualifications: College or University degree	1.5	4.7	16.8	-0.7	4.1	0.6	-1.1
Chest pain or discomfort	1.5	2.2	7.5	0.1	-0.6	1.0	2.7
Ever had prostate specific antigen (PSA) test	1.5	1.8	3.8	-0.4	1.2	-2.0	-1.2
Schizophrenia vs Biploar Disorder	1.4	1.8	2.9	-1.0	-0.5	1.7	-1.7
Serious illness, injury or assault to yourself	1.4	1.6	5.1	-0.8	-2.3	-0.9	0.1
Comparative body size at age 10	1.4	4.0	7.9	2.1	2.8	-1.7	0.7
Had major operations	1.4	1.7	3.6	-0.9	-1.3	-0.8	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	3.6	-1.8	0.3	1.9	0.2
Unable to work because of sickness or disability	1.4	1.8	3.7	-0.4	-1.9	-1.7	0.6
Coronary Artery Disease (CAD)	1.3	1.6	3.4	-1.9	0.9	0.7	-1.3
Age when periods started (menarche)	1.3	3.1	9.2	-0.2	-1.6	3.0	0.9
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	7.2	-0.2	1.1	2.7	0.3
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	4.3	1.3	-0.7	-0.0	2.1
Alzheimer’s Disease (in father)	1.2	1.3	2.0	1.4	-1.0	-1.1	1.0
Chronotype (morning person)	1.2	2.9	6.5	1.1	2.5	-0.7	-1.8
Maternal smoking around birth	1.2	1.7	5.1	-0.1	1.2	-2.2	0.7
Waist circumference	1.2	4.2	16.0	0.6	4.0	0.0	0.8
Had menopause	1.2	1.5	3.8	0.2	-1.5	1.9	-0.1
Pain all over the body in last month	1.2	1.2	2.2	-0.6	-0.6	1.5	-1.4
Weight	1.2	5.9	15.4	1.9	3.9	-0.0	2.2
Length of working week for main job	1.2	1.4	3.5	1.0	1.9	-0.2	0.9
Alcohol intake frequency.	1.2	2.8	4.8	1.9	-2.2	-0.4	1.6
Illnesses of siblings: Diabetes	1.2	1.5	2.5	1.2	-0.8	-1.2	1.6
Eye problems/disorders: Cataract	1.2	1.4	3.5	1.9	0.7	0.8	0.9
Illnesses of father: None of the above (group 1)	1.2	1.5	2.4	1.3	1.6	0.4	1.3
Ever taken oral contraceptive pill	1.2	1.4	3.8	0.5	0.9	0.8	1.9
Bipolar Disorder (2018)	1.1	1.8	6.4	0.9	-0.0	0.0	2.5
Schizophrenia (2018)	1.1	2.3	7.0	0.9	-2.6	0.6	-1.0
Sensitivity / hurt feelings	1.1	1.9	6.0	0.3	0.8	2.5	0.9
Hand grip strength (right)	1.1	3.0	10.1	-0.7	3.2	-0.2	1.1
Multivitamins +/- minerals	1.1	1.4	3.1	-0.1	-1.4	0.6	1.8
Breastfed as a baby	1.1	1.4	4.5	-0.4	-2.1	0.8	-0.4
High blood pressure (siblings)	1.1	1.5	4.3	0.7	1.0	-2.1	-0.6
Leg pain on walking	1.1	1.4	2.5	1.3	-1.1	-1.6	0.4
Ever had bowel cancer screening	1.1	1.3	4.7	-0.4	0.4	-0.2	-2.2
Back pain experienced in last month	1.1	1.6	3.3	1.2	-0.7	1.8	1.0
Pack years of smoking	1.1	1.6	3.0	-1.7	-1.0	-1.4	-0.7
Breast Cancer	1.0	2.4	6.9	0.1	2.6	-0.8	-1.5
Qualifications: CSEs or equivalent	1.0	1.3	3.6	-1.9	-0.7	0.8	-0.8
Stomach or abdominal pain in last month	1.0	1.2	3.1	0.4	1.8	0.8	1.0
Supplements: Glucosamine	1.0	1.3	2.9	-0.1	-1.1	-1.1	-1.7
Illnesses of siblings	1.0	1.4	3.7	-1.9	-0.6	1.2	-0.2
Time employed in main current job	1.0	1.2	3.0	0.9	1.7	0.5	0.8
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	4.1	-0.2	2.0	-0.6	-0.8
Depression (self-reported)	1.0	1.2	3.7	0.1	-1.9	1.0	-0.5
Number of children fathered	1.0	1.2	2.2	-1.5	0.6	0.6	-1.3
Hypertension (Self-reported)	1.0	2.6	5.1	2.3	-1.1	-1.4	1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	4.8	1.6	0.8	-0.6	2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	5.4	-1.6	0.8	0.3	-2.3
Number of self-reported non-cancer illnesses	1.0	1.8	4.2	2.0	-0.5	-1.2	1.2
Miserableness	1.0	1.7	4.8	0.3	1.4	2.2	0.3
Alcohol drinker status: Previous	1.0	1.2	2.2	0.9	-1.5	-0.8	1.0
Prostate Cancer	0.9	1.3	2.3	-0.5	-1.2	-1.5	-1.0
Primary Biliary Cirrhosis	0.9	1.3	4.5	-0.8	-2.1	0.4	-0.1
Triglycerides	0.9	1.4	2.7	0.3	1.1	-1.3	-1.6
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	1.9	1.4	1.4	-0.6	0.6
Alcohol intake versus 10 years previously	0.9	1.3	3.6	1.9	-0.3	-0.8	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	3.0	0.8	1.4	1.7	0.9
Noisy workplace	0.9	1.1	2.4	0.1	-0.9	1.1	1.6
Medication: Lansoprazole	0.9	1.0	2.3	-1.2	-0.5	1.5	-0.0
Lung cancer (father)	0.9	1.0	2.6	-1.1	-0.2	0.6	-1.6
Blood clot in the leg (DVT)	0.9	1.2	3.1	-0.4	-1.1	-1.8	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.5	1.3	-0.4	1.6	-0.4
Age at first live birth	0.9	1.6	4.6	0.2	2.1	0.4	-1.3
Medication: Ibuprofen	0.9	1.1	2.2	0.1	1.5	-0.9	-1.1
Age at last live birth	0.9	1.3	1.9	1.4	1.3	1.1	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.0	1.4	-0.1	1.1	0.7
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	4.6	-0.9	2.1	-0.2	-0.3
Asthma (self-reported)	0.9	1.8	6.3	0.3	2.5	-0.6	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.5	0.4	1.6	1.2	0.5
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.5	-0.7	-1.1	-1.6	0.5
Ulcerative Colitis (UC)	0.8	1.5	5.7	-0.4	0.3	2.4	0.2
Schizophrenia (2014)	0.8	1.8	3.1	1.6	-1.8	1.2	-0.1
Lung FEV1/FVC ratio	0.8	4.1	10.7	2.1	3.3	-0.6	0.9
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.2	-0.2	0.1	1.5	1.1
Vitamin and mineral supplements	0.8	1.0	2.2	-0.4	1.3	0.2	-1.5
Number of incorrect matches in round	0.8	1.3	3.3	-0.8	-1.1	0.1	-1.8
Asthma	0.8	1.6	5.9	0.3	2.4	-0.6	-0.4
Birth weight of first child	0.8	1.4	2.6	-1.0	1.1	-0.9	-1.6
Glaucoma (self-reported)	0.8	0.9	1.8	1.2	1.3	-0.2	0.7
Medication: Amlodipine	0.8	1.1	2.6	0.4	1.3	-0.4	-1.6
Worry too long after embarrassment	0.8	1.3	3.2	0.7	1.8	1.1	-0.1
Medication: Seretide 50 evohaler	0.8	1.0	2.3	1.0	-0.7	-1.5	-0.2
Supplements: Vitamin C	0.8	0.9	2.3	0.4	-1.5	-0.9	-0.5
Smoking status: Previous	0.8	1.2	4.4	0.5	-0.1	2.1	0.1
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.0	0.9	0.9	-1.4	-0.4
Loneliness, isolation	0.8	1.1	1.9	1.4	1.1	0.8	0.7
Financial situation satisfaction	0.8	1.0	2.0	0.7	0.3	-1.1	1.4
Eye problems/disorders: Glaucoma	0.8	0.9	1.9	1.2	0.5	-0.0	1.4
Irritability	0.8	1.4	3.5	1.2	0.5	-0.6	1.9
Basal cell carcinoma (self-reported)	0.8	0.9	1.6	1.1	-0.7	0.5	1.3
Bipolar Disorder or Schizophrenia	0.7	1.7	4.3	1.2	-2.1	0.5	0.8
Alzheimer’s Disease (in mother)	0.7	0.9	2.6	-1.6	-0.3	0.3	-0.9
Verbal and Numeric Reasoning (VNR)	0.7	1.8	3.7	-0.6	1.7	-0.0	-1.9
Fasting Glucose	0.7	0.9	1.4	-1.2	-0.1	-1.2	-0.9
HbA1C	0.7	0.8	1.8	-1.0	-0.4	-0.5	-1.3
LDL Cholesterol	0.7	1.1	2.0	-0.4	-1.4	-0.5	-1.4
Lupus	0.7	1.0	2.0	1.1	-0.6	-0.8	1.4
Rheumatoid Arthritis	0.7	0.9	1.5	-1.2	-1.1	-0.9	-0.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.9	1.1	0.6	1.4	0.4
Diabetes (mother)	0.7	0.9	2.6	0.8	-1.6	0.5	-0.0
Pack years adult smoking proportion	0.7	1.1	1.6	-1.3	-1.1	-1.2	-0.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	3.2	0.2	1.8	-0.4	0.2
Sitting height	0.7	4.8	12.2	3.5	1.5	-0.6	2.1
Body mass index (BMI)	0.7	3.1	11.2	0.8	3.3	-0.5	0.7
Qualifications: None of the above	0.7	1.6	5.6	0.7	-2.4	0.3	-0.1
Allergy	0.7	1.7	3.9	-1.5	-2.0	-0.2	-0.8
Hip circumference	0.7	3.1	10.2	0.9	3.2	-0.4	1.1
Pulse wave reflection index	0.7	0.8	1.8	-0.2	1.1	-1.4	0.5
Gout (self-reported)	0.7	0.9	2.1	0.5	1.4	-0.1	1.2
Medication for pain relief, constipation, heartburn	0.7	1.2	2.5	0.1	-1.6	-1.2	0.9
Heart disease (mother)	0.7	0.8	2.8	-1.7	0.1	-0.1	-0.6
Knee pain experienced in last month	0.7	1.1	2.8	0.9	1.7	0.5	0.9
Friendships satisfaction	0.7	0.8	2.2	1.5	-0.9	-0.0	-0.4
Mineral and other dietary supplements	0.7	1.0	2.8	-0.8	1.7	0.6	0.1
Osteoarthritis (self-reported)	0.7	0.9	1.6	-0.9	1.0	-0.4	1.3
High cholesterol (Self-reported)	0.7	1.2	4.3	0.3	-2.1	-0.8	0.0
Medication: Bendroflumethiazide	0.7	1.0	2.8	1.7	0.7	-0.7	0.5
Medication: Lisinopril	0.7	1.0	2.0	1.4	-0.4	-0.9	0.9
Ever smoked	0.7	1.2	3.1	-1.0	-0.6	1.8	0.7
Age started oral contraceptive pill	0.7	0.9	2.7	1.6	-0.4	0.2	0.9
Ulcerative Colitis	0.6	0.9	1.2	-0.7	1.1	1.1	0.7
BMI	0.6	3.3	11.8	0.9	3.4	0.0	0.8
Height	0.6	12.5	27.4	3.3	1.4	3.1	5.2
Allergy or Eczema	0.6	1.7	3.8	1.4	1.9	0.3	1.0
Cardiovascular Disease	0.6	2.1	3.4	1.4	-1.2	-1.9	1.2
Hand grip strength (left)	0.6	1.7	6.6	-0.4	2.6	0.2	-0.1
Hearing difficulty/problems: Yes	0.6	0.9	1.3	-1.1	-1.1	-0.9	-0.5
Medication: Co-codamol	0.6	0.7	2.6	-0.2	1.6	0.5	-0.1
High blood pressure	0.6	1.6	2.4	1.5	-1.1	-1.5	0.8
Had other major operations	0.6	0.7	2.4	0.2	1.5	0.5	0.5
Hair/balding pattern: Pattern 3	0.6	1.0	1.7	1.0	-0.9	-1.3	-0.6
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.5	1.3	1.6	-0.8	0.6
Medication: Cholesterol lowering	0.6	0.9	1.8	0.3	-1.3	-1.3	-0.1
Illnesses of mother	0.6	0.7	1.0	-0.8	0.7	-1.0	0.8
Arm fat mass (right)	0.6	2.5	8.2	0.8	2.9	0.3	1.0
Standing height	0.6	5.5	12.2	2.3	1.8	1.1	3.5
Hair/balding pattern: Pattern 4	0.6	1.4	3.9	-0.3	-0.2	2.0	-1.3
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.9	1.4	1.3	-0.6	-0.4
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.1	1.4	0.0	1.3	1.1
Medication: Blood pressure	0.6	1.0	2.5	1.2	0.3	-1.6	-0.1
Medication: Allopurinol	0.6	0.8	1.3	1.2	1.0	-0.6	0.7
Comparative height size at age 10	0.6	3.4	10.2	1.8	0.6	0.1	3.2
Family relationship satisfaction	0.6	0.8	1.7	-0.9	0.8	-0.2	-1.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.5	-1.2	-0.1	0.0	-1.2
Qualifications: nursing, teaching	0.6	0.9	2.0	0.6	1.4	0.9	0.4
Arm fat mass (left)	0.6	2.6	7.8	1.1	2.8	0.2	1.2
Average weekly champagne plus white wine intake	0.6	0.8	1.9	-0.3	1.4	1.0	0.5
Mother’s age at death	0.6	0.8	1.8	0.1	1.3	1.2	-0.1
Average weekly beer plus cider intake	0.6	0.9	2.4	-0.4	0.5	1.6	-0.8
Ever depressed for a whole week	0.6	0.8	1.4	0.7	-1.2	0.2	1.0
Depression (Nagel 2018)	0.5	0.8	1.9	0.6	1.4	0.9	0.1
Waist Hip Ratio (WHR)	0.5	2.3	6.6	-0.4	2.6	1.4	-0.7
Lung FVC	0.5	2.7	5.2	-2.2	-0.7	-0.3	-2.3
Neuroticism	0.5	1.3	3.4	0.4	1.8	1.3	-0.1
Systolic blood pressure, automated reading	0.5	1.4	4.9	0.8	-2.2	-0.3	0.4
Supplements: Zinc	0.5	0.6	1.0	1.0	-0.1	0.6	0.9
Severe depression (siblings)	0.5	0.6	1.0	-0.2	-0.8	0.8	1.0
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.7	-0.4	-1.3	-0.4	0.4
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.6	1.3	1.6	0.2	0.5
High blood pressure (mother)	0.5	0.7	2.3	0.6	0.1	-0.0	-1.5
Past tobacco smoking	0.5	0.8	2.7	0.2	0.5	-1.6	-0.6
Alcohol usually taken with meals	0.5	0.7	1.8	0.1	1.3	-1.0	0.3
Nervous feelings	0.5	0.9	1.6	-0.7	-1.3	0.6	-1.0
Diabetes (self-reported)	0.5	0.7	2.8	1.7	0.4	0.1	-0.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.1	-0.1	1.4	0.7	-0.1
Exposure to tobacco smoke outside home	0.5	0.6	1.3	1.2	0.8	-0.5	0.5
Emphysema/chronic bronchitis	0.5	0.6	1.4	0.1	-1.0	-0.1	1.2
Medication: Omeprazole	0.5	0.6	1.9	-0.0	1.4	0.6	-0.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	0.8	0.9	-0.8	0.3	-0.9
Average weekly red wine intake	0.5	0.7	2.1	0.6	-0.4	-0.2	-1.4
Mood swings	0.5	1.0	3.1	0.8	1.8	-0.4	-0.1
Wears glasses or contact lenses	0.5	0.6	0.8	-0.7	-0.9	0.7	-0.8
Illnesses of father: High blood pressure	0.5	0.6	1.1	0.5	0.5	-0.8	1.1
Number of operations (self-reported)	0.5	0.8	3.0	0.1	1.7	-0.2	-0.0
Risk taking	0.5	0.7	2.4	0.3	-0.2	0.5	1.6
Pain experienced in last month	0.5	0.9	1.7	-1.3	-0.1	-0.8	-1.1
Irritable Bowel Disease (IBD)	0.4	1.0	2.9	-0.1	0.6	1.7	0.7
Major Depression (MDD)	0.4	0.4	1.5	1.2	-0.4	0.2	0.1
Bipolar Disorder (2011)	0.4	0.3	1.3	1.1	-0.2	-0.1	0.0
Blood Eosinophil Count	0.4	3.0	6.6	-2.6	2.0	-0.0	-1.2
Blood White Count	0.4	3.0	7.0	-2.6	1.8	1.1	-0.8
Number of treatments/medications taken	0.4	0.8	3.0	0.1	0.3	-1.7	-0.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.9	0.5	1.0	-0.8	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.1	1.1	-1.1	-0.3	0.4
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.0	0.6	-1.0	-0.6	0.5
Leg fat percentage (right)	0.4	1.5	2.6	-1.6	0.8	-0.8	-1.5
Wheeze or whistling in the chest in last year	0.4	0.7	1.6	-0.6	1.3	0.2	0.9
Whole body fat mass	0.4	1.7	6.2	0.4	2.5	0.1	0.8
Leg fat mass (right)	0.4	1.6	6.1	0.2	2.5	-0.6	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.9	-0.6	0.8	0.9	-0.2
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.0	0.6	-0.5	-0.5	1.0
Supplements: Calcium	0.4	0.4	1.6	0.3	-0.0	1.2	-0.1
Leg fat mass (left)	0.4	1.6	5.9	0.3	2.4	-0.5	0.2
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.5	-0.7	1.1	0.4	-1.2
Age at First Birth	0.3	0.4	0.6	-0.8	-0.8	0.2	-0.8
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.6	0.8	0.8	-0.1	0.0
Systolic Blood Pressure	0.3	1.6	5.0	0.4	-2.2	-0.9	-0.5
Smoking Status	0.3	0.6	1.8	-0.5	-0.6	1.3	0.3
Respiratory disease	0.3	0.7	1.6	-0.2	1.3	-0.7	-0.7
Medication for hormone replacement therapy	0.3	0.4	0.9	0.4	0.4	1.0	-0.5
Medication: Metformin	0.3	0.5	0.6	0.5	-0.8	-0.7	-0.7
Relative age voice broke	0.3	0.5	1.3	0.3	1.1	-0.1	0.8
Medication: Atenolol	0.3	0.4	0.8	-0.1	-0.8	0.9	-0.3
Medication: Levothyroxine sodium	0.3	0.5	1.0	0.5	1.0	0.2	0.8
Trunk fat mass	0.3	1.4	4.3	0.5	2.1	0.0	0.9
Neuroticism score	0.3	0.7	1.4	0.5	1.2	0.9	0.5
Father’s age at death	0.3	0.4	1.0	1.0	-0.4	0.1	0.7
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.2	-0.5	1.5	0.9	-0.7
Pulse rate	0.3	0.4	0.9	-0.1	-1.0	0.4	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.2	-0.8	1.5	0.8	0.2
Headache pain in last month	0.3	0.5	1.4	-0.3	-1.2	0.1	0.6
Birth weight	0.3	0.7	1.2	1.1	-0.8	-0.8	0.4
Neck or shoulder pain in last month	0.3	0.4	1.1	1.0	0.2	-0.3	0.5
Medication: Aspirin	0.3	0.3	0.5	0.6	-0.6	0.7	-0.3
Diabetes diagnosed by doctor	0.3	0.4	1.6	1.3	-0.1	-0.2	-0.0
Commuting to job workplace: Walk	0.3	0.3	0.6	0.5	0.5	0.8	-0.2
Medication: Gliclazide	0.3	0.3	0.7	-0.2	-0.8	-0.2	-0.7
Hearing aid user	0.3	0.3	0.7	-0.8	-0.3	0.6	-0.4
Commuting to job workplace: Public transport	0.3	0.4	0.6	0.6	0.7	0.2	0.8
Medication: Blood pressure	0.3	0.6	1.5	1.2	-0.6	0.6	0.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.0	1.0	0.7	-0.2	0.3
Leg fat percentage (left)	0.3	1.2	1.9	-1.4	0.8	-0.9	-1.2
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.6	-1.3	0.9	0.8	-0.7
Heart disease (siblings)	0.3	0.4	0.9	0.4	0.5	0.9	0.5
Depressed Affect (Nagel 2018)	0.2	0.4	0.7	-0.7	0.3	0.8	-0.6
Neuroticism (Nagel 2018)	0.2	0.6	1.0	-0.4	0.9	1.0	-0.5
Worry (Nagel 2018)	0.2	0.4	1.2	-0.5	0.0	-0.2	-1.1
Crohns Disease (2012)	0.2	0.3	0.4	-0.6	0.4	0.4	-0.6
Hypothyroidism (self reported)	0.2	0.5	0.8	0.6	0.1	0.9	0.8
Average weekly spirits intake	0.2	0.3	0.9	0.1	-1.0	-0.3	0.3
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.8	0.2	0.9	0.2	-0.0
Ever had hysterectomy (womb removed)	0.2	0.2	0.7	-0.3	0.8	-0.2	-0.3
Diabetes (father)	0.2	0.2	0.5	-0.3	0.7	-0.3	-0.4
Average weekly fortified wine intake	0.2	0.3	0.9	0.9	0.0	0.2	0.3
Fed-up feelings	0.2	0.4	1.4	-0.5	0.2	1.2	-0.2
Taking other prescription medications	0.2	0.3	1.0	-0.0	0.2	-0.6	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.5	0.7	0.7	0.1	0.6
Heart attack	0.2	0.2	0.5	-0.7	-0.5	0.3	-0.2
Medication: Ramipril	0.2	0.3	0.8	0.3	0.9	0.3	0.3
Medication: Simvastatin	0.2	0.3	1.0	1.0	0.3	-0.3	0.4
Worrier / anxious feelings	0.2	0.4	1.3	1.2	0.1	-0.2	-0.4
Prospective memory result	0.2	0.3	0.8	-0.2	0.3	0.4	-0.9
Exposure to tobacco smoke at home	0.2	0.3	0.6	-0.5	-0.8	-0.5	0.0
Tense / ‘highly strung’	0.2	0.4	0.9	0.0	-0.7	0.9	0.3
Forced vital capacity (FVC), Best measure	0.2	0.6	1.7	-1.3	0.7	0.4	-0.3
Long-standing illness, disability or infirmity	0.2	0.4	0.8	0.7	-0.3	-0.0	0.9
Medication for cholesterol	0.2	0.3	0.6	-0.8	-0.5	0.6	0.2
Breast cancer (self-reported)	0.2	0.3	1.0	0.2	-1.0	0.2	-0.0
Medication: Aspirin	0.2	0.3	0.4	0.6	-0.4	0.7	-0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.9	0.5	-0.9	-0.3	0.0
Medication: Paracetamol	0.2	0.3	0.8	-0.4	0.9	-0.1	-0.1
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.6	-0.8	-0.4	0.3	-0.3
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	-0.6	-0.5	-0.1	0.1
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.4	-0.0	-0.2	-0.4
Blood Platelet Count	0.1	1.5	4.2	0.9	-0.9	2.0	0.1
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.3	0.4	-0.3	-0.6	0.2
Hair Pigment	0.1	3.2	7.6	0.8	2.8	-1.0	1.9
Tanning	0.1	0.7	1.4	-0.2	0.5	-1.0	1.2
Trunk fat percentage	0.1	0.2	0.4	-0.6	0.6	0.4	0.2
Current tobacco smoking	0.1	0.2	0.4	-0.5	-0.3	0.3	0.6
Hearing difficulty/problems with background noise	0.1	0.2	0.4	0.6	-0.6	-0.0	0.4
Forced vital capacity (FVC)	0.1	0.5	0.7	-0.8	0.2	0.7	-0.8
Fluid intelligence score	0.1	0.2	0.5	-0.0	0.7	-0.1	-0.4
Arm fat percentage (right)	0.1	0.4	1.6	-0.1	1.3	0.3	0.2
Falls in the last year	0.1	0.1	0.1	0.3	-0.3	0.4	-0.3
Happiness	0.1	0.1	0.2	0.3	0.4	-0.2	0.2
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.1	0.3	-0.4	0.3
Medication: Paracetamol	0.1	0.1	0.3	-0.4	0.6	0.2	-0.2
Body fat percentage	0.1	0.4	0.8	-0.9	0.8	-0.1	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.3	-0.4	0.4	-0.3	-0.5
Pulse wave peak to peak time	0.1	0.1	0.4	0.1	-0.1	0.6	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.3	-0.4	-0.1	0.0	-0.6
Suffer from ‘nerves’	0.1	0.1	0.3	0.3	0.5	-0.0	-0.1
Overall health rating	0.1	0.3	0.8	-0.2	-0.1	0.9	0.6
Arm fat percentage (left)	0.1	0.6	2.0	-0.1	1.4	0.2	0.4
Smoking status: Current	0.1	0.2	0.4	-0.5	-0.3	0.0	0.6
Alcohol drinker status: Never	0.1	0.1	0.2	0.4	-0.4	0.1	0.3
Diastolic blood pressure, automated reading	0.1	0.3	1.0	0.3	-1.0	0.1	-0.4
Cholesterol lowering medication	0.1	0.1	0.3	0.2	0.5	-0.0	-0.5
Crohns Disease (2017)	0.0	0.1	0.3	0.5	-0.1	-0.0	0.3
Neuroticism (2016)	0.0	0.0	0.0	0.0	-0.0	-0.1	-0.1
Pulse rate, automated reading	0.0	0.1	0.4	0.6	-0.1	0.0	-0.2

Hub : Genes

SMARCD3

Models

Trait associations