TWAS hub - SLC4A2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.1100	0.0430	0.00390	0.026	NA	0.063	NA	0.036	7.3e-03	NA	5.1e-05	NA	1.8e-03
2	YFS	Blood	0.0277	0.0097	0.00088	0.021	0.013	0.019	0.017	0.021	1.1e-07	3.1e-05	4.5e-07	1.4e-06	1.5e-07
3	TCGA	Colon Adenocarcinoma	0.1310	0.0580	0.00340	0.000	0.034	0.018	NA	0.011	3.3e-01	4.5e-03	2.9e-02	NA	6.9e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Fractured/broken bones in last 5 years	7.9	10.2	11.8	2.8	3.3	-3.4
Mean Putamen Volume	6.0	6.8	10.5	2.9	3.2	-1.3
Blood Red Count	5.6	54.0	104.0	10.2	6.4	-4.1
Chronic bronchitis/emphysema (father)	5.6	6.5	9.0	-2.8	-3.0	1.6
Heel bone mineral density (BMD) T-score, automated (right)	4.7	10.8	15.1	-3.4	-3.9	2.3
Mineral and other dietary supplements	4.6	6.2	12.4	1.7	1.8	-3.5
Length of working week for main job	4.4	4.9	8.7	2.3	2.9	-1.0
Qualifications: None of the above	4.2	9.0	13.7	-3.7	-2.3	2.8
Heel T-Score	4.0	31.8	46.5	-6.0	-6.8	3.6
Hearing difficulty/problems: Yes	4.0	6.1	13.7	-2.0	-3.7	0.8
Maternal smoking around birth	3.9	5.6	8.4	1.6	2.9	-2.4
Supplements: Glucosamine	3.9	5.1	7.0	-2.6	-1.6	2.4
Impedance of whole body	3.6	18.6	38.4	-6.2	-3.2	2.7
HDL Cholesterol	3.5	5.9	12.9	-3.6	-2.0	0.9
Impedance of leg (right)	3.4	16.4	32.7	-5.7	-2.0	3.5
Leg fat-free mass (right)	3.4	18.4	40.4	6.4	1.9	-3.3
Leg predicted mass (right)	3.4	18.2	39.3	6.3	1.9	-3.4
Waist circumference	3.3	12.0	15.6	4.0	2.6	-3.7
Hand grip strength (left)	3.2	8.5	18.4	4.3	2.6	-0.7
Impedance of leg (left)	3.2	15.7	32.6	-5.7	-2.0	3.2
Leg predicted mass (left)	3.2	17.0	36.8	6.1	1.9	-3.3
Impedance of arm (left)	3.2	14.9	30.9	-5.6	-3.3	1.6
Arm predicted mass (right)	3.2	16.5	40.7	6.4	2.5	-1.6
Whole body fat-free mass	3.2	18.4	45.3	6.7	2.6	-1.8
Back pain experienced in last month	3.2	4.7	12.5	-0.6	-1.1	3.5
Whole body water mass	3.2	18.4	45.8	6.8	2.6	-1.7
Arm predicted mass (left)	3.2	16.5	39.3	6.3	2.6	-1.8
Leg fat-free mass (left)	3.1	16.7	36.5	6.0	1.8	-3.2
Trunk fat-free mass	3.1	17.7	44.9	6.7	2.8	-0.7
Trunk predicted mass	3.1	17.7	44.8	6.7	2.8	-0.7
Arm fat-free mass (right)	3.1	16.1	39.9	6.3	2.5	-1.5
Basal metabolic rate	3.1	17.0	39.9	6.3	2.4	-2.3
Breast Cancer	3.0	7.3	10.7	3.3	2.8	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	3.0	6.7	9.4	-3.1	-3.0	1.4
Impedance of arm (right)	2.9	13.5	27.8	-5.3	-3.0	1.9
Supplements: Vitamin C	2.9	3.4	5.4	-0.6	-2.3	2.1
Medication: Ibuprofen (e.g. Nurofen)	2.8	3.6	7.5	2.7	1.8	-0.1
Arm fat-free mass (left)	2.8	14.4	35.2	5.9	2.5	-1.4
Bipolar Disorder or Schizophrenia	2.7	6.7	11.0	-1.3	-2.7	3.3
Hand grip strength (right)	2.7	7.3	17.8	4.2	1.7	-1.1
Breastfed as a baby	2.7	3.4	7.0	-0.8	-1.6	2.6
Mean time to correctly identify matches	2.7	5.1	9.3	-2.3	-0.9	3.0
Schizophrenia (2018)	2.6	5.4	9.1	-1.0	-3.0	2.5
Qualifications: College or University degree	2.5	7.8	15.4	3.9	2.0	-2.0
Fasting Glucose	2.4	2.9	5.8	1.4	-0.9	2.4
Schizophrenia (2014)	2.4	5.3	7.7	-0.9	-2.8	2.7
Chronotype (morning person)	2.4	5.5	9.7	3.1	2.6	-0.4
Vitamin and mineral supplements	2.4	3.3	5.4	0.8	2.3	-1.9
Medication: Co-codamol	2.4	2.8	4.2	1.8	2.1	1.0
Comparative body size at age 10	2.4	6.6	8.8	3.0	2.9	-1.5
Frequency of depressed mood in last 2 weeks	2.3	3.3	6.1	0.8	1.8	-2.5
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	6.1	1.4	2.5	0.3
Body mass index (BMI)	2.3	10.0	18.0	2.8	2.0	-4.2
Hearing difficulty/problems with background noise	2.3	3.7	4.6	-2.1	-2.0	1.6
Peak expiratory flow (PEF)	2.3	5.4	12.7	3.6	1.9	0.3
Medication: Ventolin 100micrograms inhaler	2.3	3.0	4.3	1.5	2.1	-1.5
Number of full brothers	2.3	2.9	5.4	-1.1	-1.4	2.3
Osteoporosis (self-reported)	2.3	2.9	7.7	1.0	2.8	0.2
Supplements: Fish oil (including cod liver oil)	2.3	3.0	8.5	-0.2	-0.7	2.9
BMI	2.2	12.9	26.1	3.3	1.3	-5.1
Sensitivity / hurt feelings	2.2	3.7	7.8	0.9	1.6	-2.8
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	4.6	-1.5	-1.2	2.1
Neuroticism	2.1	5.1	8.4	1.7	2.1	-2.9
Ever highly irritable/argumentative for 2 days	2.1	2.5	4.0	1.7	0.8	-2.0
Blood clot in the leg (DVT)	2.1	2.7	3.9	-2.0	-1.5	-1.4
Deep venous thrombosis (DVT) (self-reported)	2.1	2.6	3.8	-1.9	-1.5	-1.4
Multivitamins +/- minerals	2.0	2.6	5.3	-0.6	-1.4	2.3
Weight	2.0	9.9	18.6	4.3	1.5	-2.9
Forced expiratory volume in 1-second (FEV1)	2.0	6.7	17.2	4.2	1.5	0.9
Arm fat mass (right)	2.0	8.1	13.1	2.7	2.0	-3.6
Worry too long after embarrassment	2.0	3.3	4.0	2.0	1.8	-1.6
Basal cell carcinoma (self-reported)	2.0	2.4	3.8	-0.3	-1.9	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	5.9	13.0	3.6	2.0	0.7
Guilty feelings	1.9	2.8	4.5	2.1	1.6	-1.1
Depression (Nagel 2018)	1.8	2.7	3.9	1.4	1.5	-2.0
Fed-up feelings	1.8	3.2	6.3	1.0	2.5	-1.5
Had menopause	1.8	2.2	3.5	-1.3	-1.2	1.9
Hip circumference	1.8	7.6	11.6	3.4	1.8	-2.9
Medication: Cholesterol lowering	1.8	2.8	4.8	-0.5	-1.8	-2.2
Medication: Lansoprazole	1.8	2.1	2.8	1.7	-0.8	1.7
Leg fat mass (right)	1.8	7.0	12.3	2.3	1.8	-3.5
Average weekly red wine intake	1.8	2.6	7.3	-0.7	0.3	2.7
Arm fat mass (left)	1.8	7.4	11.9	2.7	1.8	-3.4
Depression (self-reported)	1.7	2.0	5.5	-2.3	-0.4	0.6
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	5.2	1.3	1.3	2.3
Medication for pain relief, constipation, heartburn	1.7	2.8	4.5	-2.1	-2.0	0.2
Leg fat mass (left)	1.7	6.8	12.1	2.2	1.8	-3.5
Illnesses of siblings	1.6	2.2	3.5	-1.9	-1.6	-0.7
Gout (self-reported)	1.6	2.2	3.3	0.9	1.6	-1.8
Illnesses of father: None of the above (group 1)	1.6	2.0	5.0	2.2	0.8	-0.6
Financial difficulties in last 2 years	1.5	2.1	5.1	0.4	0.9	-2.3
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	4.3	-0.7	-2.1	0.6
Neck or shoulder pain in last month	1.5	2.1	3.8	0.2	1.6	1.9
Leg pain on walking	1.5	1.9	2.5	-1.6	-1.4	1.1
Unable to work because of sickness or disability	1.5	2.0	4.3	-2.1	-1.2	-0.2
Neuroticism (Nagel 2018)	1.4	3.2	6.8	1.2	1.2	-2.6
Prostate Cancer	1.4	1.9	5.2	-0.6	-2.3	0.4
Triglycerides	1.4	2.3	6.0	2.5	0.9	-0.0
Cardiovascular Disease	1.4	4.7	14.0	0.4	-0.3	-3.7
Forced vital capacity (FVC)	1.4	5.4	10.0	3.2	0.9	2.3
Forced vital capacity (FVC), Best measure	1.4	5.1	9.5	3.1	1.8	1.6
Health satisfaction	1.4	1.8	5.1	0.6	0.2	-2.2
Number of full sisters	1.4	1.7	3.7	-0.8	-1.9	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	4.6	0.4	-2.1	-0.3
Ever had bowel cancer screening	1.4	1.6	2.9	0.7	1.2	1.7
Bipolar Disorder (2018)	1.3	2.0	4.9	-0.9	-0.6	2.2
Waist Hip Ratio (WHR)	1.3	5.9	10.3	3.2	2.3	-1.4
Medication: Simvastatin	1.3	1.9	3.7	-0.5	-1.3	-1.9
Birth weight of first child	1.3	2.3	6.4	2.5	0.8	0.2
Medication: Ibuprofen	1.3	1.6	3.2	1.8	0.9	0.9
Arm fat percentage (left)	1.3	5.4	14.2	0.7	1.2	-3.8
Mood swings	1.3	2.3	3.6	1.2	1.4	-1.9
Qualifications: nursing, teaching	1.3	2.0	3.7	1.5	1.9	-0.4
Alzheimer’s Disease (in mother)	1.2	1.4	1.9	-0.8	-1.3	-1.4
Average weekly spirits intake	1.2	1.5	4.1	-0.6	0.1	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	4.5	0.5	2.1	-0.1
Neuroticism score	1.2	2.6	5.1	0.9	1.4	-2.2
Loud music exposure frequency	1.2	1.3	2.3	-1.3	-1.5	-0.0
Headache pain in last month	1.2	2.0	2.9	-1.5	-1.7	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	3.1	0.3	1.3	-1.8
Eye problems/disorders: Cataract	1.2	1.4	2.5	1.6	1.3	0.3
Vascular/heart problems diagnosed by doctor	1.2	3.4	8.5	1.0	0.8	2.9
Reaction Time	1.1	2.1	3.5	-1.9	-0.9	1.4
Age at First Birth	1.1	1.7	2.7	-1.6	-1.5	-0.3
Pack years adult smoking proportion	1.1	1.7	2.8	-0.9	-1.7	-1.2
Medication: Levothyroxine sodium	1.1	1.9	5.1	0.3	2.3	0.7
Number of live births	1.1	1.6	3.0	0.6	1.7	1.2
Glaucoma (self-reported)	1.1	1.3	1.6	0.8	1.3	1.3
Shortness of breath walking on level ground	1.1	1.3	1.9	-1.4	-0.5	-1.3
Whole body fat mass	1.1	4.7	8.2	1.9	1.4	-2.9
Miserableness	1.1	2.0	4.2	0.6	1.2	-2.0
Illnesses of father: High blood pressure	1.1	1.3	3.2	-1.8	-0.6	0.8
Diastolic blood pressure, automated reading	1.1	3.4	8.5	-0.8	1.0	-2.9
Pack years of smoking	1.1	1.6	3.1	-0.9	-1.8	-0.9
Worry (Nagel 2018)	1.0	2.1	5.7	0.7	0.2	-2.4
Diabetes (father)	1.0	1.2	1.5	0.9	1.1	-1.2
Arm fat percentage (right)	1.0	4.1	10.0	0.5	1.4	-3.2
Happiness	1.0	1.3	3.5	0.3	0.4	-1.9
Mouth/teeth dental problems: Dentures	1.0	1.6	2.1	-1.5	-0.9	1.4
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.5	-1.6	0.2	1.1
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.3	-0.7	-0.8	-1.5
Emphysema/chronic bronchitis	1.0	1.1	2.0	-1.4	-0.9	0.7
Medication: Allopurinol	1.0	1.3	2.6	0.3	1.1	-1.6
Chest pain or discomfort	1.0	1.4	2.4	-1.3	-1.6	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	1.7	1.3	1.2	0.4
Pain type(s) experienced in last month: Hip pain	1.0	1.3	1.9	-1.3	-0.4	1.4
Medication: Paracetamol	1.0	1.6	3.8	0.7	2.0	0.6
Leg fat percentage (left)	1.0	3.7	8.2	0.2	1.7	-2.9
Age started oral contraceptive pill	1.0	1.3	3.3	0.0	-0.8	1.8
Alcohol drinker status: Previous	1.0	1.2	2.3	-1.1	-1.5	-0.2
Ulcerative Colitis (UC)	0.9	1.6	2.7	-0.7	-1.6	-1.3
Ulcerative Colitis	0.9	1.2	1.9	-0.3	-1.4	-1.3
Height	0.9	17.5	33.9	3.7	-2.2	5.8
Type 2 Diabetes (T2D) (2018)	0.9	1.6	3.8	1.0	-0.2	-2.0
Lung FVC	0.9	4.8	5.1	2.1	2.2	2.2
Townsend deprivation index at recruitment	0.9	1.2	1.5	-1.2	-1.2	-0.9
Leg fat percentage (right)	0.9	3.2	7.1	-0.0	1.6	-2.7
Wheeze or whistling in the chest in last year	0.9	1.6	2.4	1.6	1.1	-1.1
Age at first live birth	0.9	1.6	2.6	0.3	1.4	-1.6
Pulse rate, automated reading	0.9	2.9	5.4	-0.2	1.8	-2.3
Comparative height size at age 10	0.9	5.1	8.2	2.6	-0.6	2.9
Family relationship satisfaction	0.9	1.1	2.4	0.4	1.6	-0.8
Long-standing illness, disability or infirmity	0.9	1.3	2.7	-0.9	-1.6	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	2.9	1.7	1.3	1.0
Wears glasses or contact lenses	0.9	1.0	1.7	-1.1	-0.1	1.3
Hearing aid user	0.9	1.0	1.5	-1.2	-1.2	-0.1
Eye problems/disorders: Glaucoma	0.9	1.1	2.8	0.6	0.1	1.7
Depressed Affect (Nagel 2018)	0.8	1.7	2.5	0.8	1.4	-1.6
Body Mass Index (BMI) (2010)	0.8	1.1	2.7	0.3	-0.8	-1.6
Rheumatoid Arthritis	0.8	1.1	1.8	-1.0	-1.4	-0.7
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.7	-1.0	-1.3	0.3
Trunk fat mass	0.8	3.3	6.7	1.6	0.9	-2.6
Nervous feelings	0.8	1.5	2.9	-1.7	-0.7	-1.1
Hair/balding pattern: Pattern 3	0.8	1.2	2.4	-1.5	-0.3	1.1
Prospective memory result	0.8	1.0	2.8	0.5	0.2	-1.7
Standing height	0.8	7.6	15.2	3.9	-0.5	2.7
Exposure to tobacco smoke at home	0.8	0.9	2.6	-1.6	-0.2	-0.1
Pulse wave reflection index	0.8	1.0	1.6	0.8	-0.7	-1.3
Medication: Blood pressure	0.8	1.5	4.1	-0.6	-0.0	-2.0
Number of self-reported non-cancer illnesses	0.8	1.4	2.3	-0.5	-1.3	-1.5
Commuting to job workplace: Public transport	0.8	0.9	1.8	-0.0	1.0	-1.3
High cholesterol (Self-reported)	0.8	1.5	2.2	-1.1	-1.5	-1.0
Ever depressed for a whole week	0.8	1.0	2.6	0.3	-1.6	-0.6
Crohns Disease (2012)	0.7	1.1	3.2	0.5	-0.1	-1.8
Respiratory disease	0.7	1.7	2.7	1.5	-0.2	-1.7
Systolic blood pressure, automated reading	0.7	1.9	4.5	-2.1	-1.2	0.1
Diabetes (mother)	0.7	0.8	2.0	-0.7	-1.4	-0.3
Severe depression (siblings)	0.7	0.8	1.9	0.6	-1.4	0.4
Age when periods started (menarche)	0.7	1.6	2.6	-1.5	-1.6	-0.4
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.5	1.2	1.0	-0.1
High blood pressure	0.7	1.9	4.9	-0.8	-0.4	-2.2
Sitting height	0.7	5.1	11.5	3.4	-0.7	1.8
Past tobacco smoking	0.7	1.3	3.1	0.9	1.8	0.1
Diabetes (self-reported)	0.7	1.1	2.1	1.0	0.2	-1.4
Medication: Paracetamol	0.7	1.2	3.2	0.3	1.8	0.6
Body fat percentage	0.7	2.9	8.2	-0.3	0.6	-2.9
Angina (self-reported)	0.7	0.9	2.5	0.2	0.1	-1.6
Medication: Omeprazole	0.7	0.8	1.3	1.1	-0.0	-1.2
Had major operations	0.7	0.8	1.4	-0.8	-0.6	1.2
Hypertension (Self-reported)	0.7	1.9	3.5	-1.3	-0.6	-1.9
Diabetes diagnosed by doctor	0.7	1.2	2.3	0.9	-0.7	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.3	1.5	-0.0	-0.5
Heart disease (siblings)	0.7	0.9	1.1	0.8	1.1	1.0
Ovarian Cancer	0.6	0.8	2.2	0.0	0.3	-1.5
Primary Biliary Cirrhosis	0.6	0.8	1.5	-0.5	-1.2	0.8
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.8	1.3	-0.4	-0.4
Blood Eosinophil Count	0.6	4.9	7.8	2.8	0.5	-2.6
Blood White Count	0.6	4.4	6.8	1.8	2.6	-1.8
Relative age of first facial hair	0.6	1.2	2.1	1.5	1.0	-0.7
Medication: Metformin	0.6	0.8	1.4	-0.3	-1.2	-1.0
Trunk fat percentage	0.6	2.3	6.6	-0.6	-0.0	-2.6
Had other major operations	0.6	0.8	1.6	0.8	1.3	-0.3
Heart attack	0.6	0.7	1.2	0.0	-1.1	-1.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.7	1.3	0.8	0.5
Father’s age at death	0.6	0.8	1.3	-1.1	-1.0	0.3
Worrier / anxious feelings	0.6	1.1	3.0	0.4	0.3	-1.7
Pulse wave Arterial Stiffness index	0.6	0.7	1.4	1.2	-0.8	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.3	-1.1	-1.2	-0.4
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.2	0.6	-0.8	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	0.9	-0.8	-0.9	0.8
Alcohol intake frequency.	0.6	1.5	3.1	-1.1	-1.8	-0.1
Age at last live birth	0.6	0.8	2.3	-0.3	1.5	-0.4
Smoking status: Previous	0.6	0.9	2.2	-0.4	-1.5	-0.5
Friendships satisfaction	0.6	0.7	2.1	-0.3	-1.5	-0.1
Asthma (self-reported)	0.6	1.1	1.9	1.2	0.2	-1.4
Osteoarthritis (self-reported)	0.6	0.7	1.1	-0.6	-1.0	0.9
Mother’s age at death	0.6	0.8	1.0	1.0	-1.0	0.4
Commuting to job workplace: Cycle	0.6	0.7	1.0	1.0	1.0	0.2
Irritable Bowel Disease (IBD)	0.5	1.2	2.3	0.3	-1.1	-1.5
Major Depression (MDD)	0.5	0.6	1.7	1.3	0.4	0.0
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.6	1.1	0.0	-1.6
Medication for hormone replacement therapy	0.5	0.5	1.4	-0.3	0.4	1.2
Supplements: Zinc	0.5	0.5	0.6	-0.7	-0.6	0.7
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.3	-0.0	1.1	0.5
Serious illness, injury or assault to yourself	0.5	0.6	1.2	-0.3	-0.7	-1.1
Mouth/teeth dental problems	0.5	0.8	1.4	0.9	1.2	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.3	-0.3	1.1	-1.1
Asthma	0.5	1.0	2.2	0.9	0.1	-1.5
Birth weight	0.5	1.1	1.7	-0.8	-0.9	1.3
Number of children fathered	0.5	0.6	0.9	0.5	0.7	-1.0
Pulse wave peak to peak time	0.5	0.6	1.0	-1.0	0.7	0.5
Overall health rating	0.5	1.1	1.8	-0.8	-0.9	-1.3
Ever smoked	0.5	0.9	1.6	-1.0	-1.3	0.1
Irritability	0.5	0.9	2.0	-0.6	-1.4	-0.6
Risk taking	0.5	0.8	1.3	1.2	0.7	-0.7
Systolic Blood Pressure	0.4	2.2	3.1	-1.8	-1.5	-1.2
Lung FEV1/FVC ratio	0.4	1.9	5.1	2.3	0.1	-0.7
Angina	0.4	0.5	1.5	-0.2	-0.3	-1.2
Relative age voice broke	0.4	0.7	1.7	1.3	0.4	-0.4
Taking other prescription medications	0.4	0.6	1.4	0.4	0.5	1.2
Qualifications: CSEs or equivalent	0.4	0.5	0.8	-0.7	0.4	-0.9
High blood pressure (mother)	0.4	0.5	0.8	-0.1	0.8	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.5	0.5	1.2	-0.5
Fluid intelligence score	0.4	0.8	1.0	1.0	-0.7	-1.0
Time employed in main current job	0.4	0.5	0.8	0.9	0.7	-0.3
Exposure to tobacco smoke outside home	0.4	0.5	1.1	0.1	1.1	0.7
Medication: Seretide 50 evohaler	0.4	0.5	1.3	-0.4	-1.1	0.2
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.0	-0.4	0.5	-1.0
Loneliness, isolation	0.4	0.5	0.8	0.5	0.8	-0.9
Commuting to job workplace: Walk	0.4	0.4	0.7	-0.5	0.8	0.6
Breast cancer (self-reported)	0.4	0.5	0.8	-0.9	-0.9	0.1
Ever taken oral contraceptive pill	0.4	0.4	0.9	-0.4	-0.4	-1.0
Medication: Bendroflumethiazide	0.4	0.6	1.2	1.1	0.8	-0.0
Medication: Lisinopril	0.4	0.5	0.5	-0.7	-0.7	-0.7
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.2	1.1	0.4	0.1
Pain experienced in last month	0.4	0.7	1.4	0.4	-0.6	-1.2
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.9	0.2	-0.9	-0.9
Crohns Disease (2017)	0.3	0.6	1.1	1.1	-0.1	-0.7
HbA1C	0.3	0.3	0.6	0.3	0.4	-0.7
LDL Cholesterol	0.3	0.5	1.1	1.1	-0.4	0.2
Allergy or Eczema	0.3	0.9	2.2	1.5	-0.4	0.6
Average weekly fortified wine intake	0.3	0.3	0.8	-0.9	0.3	0.1
Medication: Atenolol	0.3	0.3	0.7	-0.5	-0.8	0.2
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.8	-0.9	-0.4	0.2
Allergy	0.3	0.7	1.3	-0.3	0.9	1.2
Medication: Ramipril	0.3	0.3	0.7	0.5	0.2	-0.9
Pulse rate	0.3	0.6	0.8	-0.7	0.9	0.7
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.5	0.0	0.3	1.2
Eye problems/disorders: None of the above	0.3	0.3	0.6	-0.5	0.3	-0.8
Migraine (self-reported)	0.3	0.4	1.1	-0.4	0.0	-1.1
Heart disease (mother)	0.3	0.4	1.2	-0.1	1.1	-0.3
Suffer from ‘nerves’	0.3	0.5	1.0	-0.7	0.0	-1.0
Medication: Aspirin	0.3	0.5	0.8	-0.6	-0.9	-0.4
Illnesses of father: Heart disease	0.3	0.5	0.7	-0.8	0.8	-0.3
Medication: Gliclazide	0.3	0.3	0.6	-0.8	-0.1	0.5
Smoking status: Current	0.3	0.4	0.6	-0.7	0.8	0.4
Financial situation satisfaction	0.3	0.4	1.0	0.2	-0.3	-1.0
Supplements: Calcium	0.3	0.3	0.9	0.1	0.0	1.0
Alzheimer’s Disease (including proxy)	0.2	0.3	0.5	0.0	-0.7	-0.7
Coronary Artery Disease (CAD)	0.2	0.2	0.5	0.4	0.7	0.0
Hypothyroidism (self reported)	0.2	0.6	1.7	0.0	1.3	0.1
Hair Pigment	0.2	6.3	13.0	3.6	2.3	-0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.4	-0.1	-0.6	0.6
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	-0.4	0.6	-0.3
Current tobacco smoking	0.2	0.4	0.7	-0.9	0.6	0.2
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.1	1.0	-0.3	0.3
Stomach or abdominal pain in last month	0.2	0.2	0.3	0.5	0.4	-0.5
Pain all over the body in last month	0.2	0.2	0.3	-0.5	-0.5	0.2
Falls in the last year	0.2	0.2	0.7	-0.1	-0.2	-0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.7	0.6	-0.5	0.8
Hair/balding pattern: Pattern 4	0.2	0.5	1.0	0.4	-0.5	-1.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.0	-0.5	1.0	0.3
High blood pressure (siblings)	0.2	0.2	0.3	0.5	0.3	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.2	0.4	0.4	0.5
Illnesses of siblings: Diabetes	0.2	0.3	0.4	0.6	0.3	0.7
Average weekly champagne plus white wine intake	0.2	0.2	0.7	0.0	-0.1	-0.8
Medication: Atorvastatin	0.2	0.2	0.4	0.4	-0.6	-0.3
Alcohol drinker status: Never	0.2	0.2	0.3	-0.0	-0.6	-0.5
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.5	0.1	-0.7	-0.6
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.6	-0.1	-0.1
Lupus	0.1	0.1	0.2	-0.2	-0.3	0.4
Neuroticism (2016)	0.1	0.1	0.1	-0.2	0.3	-0.3
Blood Platelet Count	0.1	0.8	1.2	-1.1	0.7	0.9
Number of treatments/medications taken	0.1	0.2	0.4	0.3	0.6	0.2
Number of incorrect matches in round	0.1	0.2	0.4	-0.6	-0.2	0.5
Alcohol intake versus 10 years previously	0.1	0.1	0.3	-0.2	0.5	0.2
Noisy workplace	0.1	0.1	0.3	-0.6	-0.2	0.3
Lung cancer (father)	0.1	0.1	0.2	0.1	0.4	0.4
Illnesses of mother	0.1	0.2	0.4	0.6	0.3	0.3
Tense / ‘highly strung’	0.1	0.2	0.3	0.4	0.5	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.1	0.2	0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.5	0.2	0.4
Knee pain experienced in last month	0.1	0.1	0.3	0.1	-0.6	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.4	0.2	-0.7	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	0.0	-0.6	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.5	0.4	0.7	-0.2
Medication for cholesterol	0.1	0.1	0.2	-0.3	-0.5	0.2
Medication: Aspirin	0.1	0.1	0.1	-0.3	-0.4	-0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	0.3	-0.2	0.5
Medication: Blood pressure	0.1	0.2	0.4	-0.3	-0.5	-0.6
Number of operations (self-reported)	0.1	0.2	0.3	0.4	0.5	0.3
Average weekly beer plus cider intake	0.1	0.2	0.3	0.4	0.6	-0.1
Alzheimer’s Disease (in father)	0.0	0.0	0.0	0.2	-0.1	0.1
Bipolar Disorder (2011)	0.0	0.0	0.1	0.2	-0.2	0.0
Smoking Status	0.0	0.1	0.2	0.1	-0.5	-0.2
Tanning	0.0	0.2	0.4	0.6	0.4	-0.3
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	-0.2	-0.2	0.1
Alcohol usually taken with meals	0.0	0.1	0.1	-0.4	0.2	-0.2
Hair/balding pattern: Pattern 2	0.0	0.1	0.1	0.4	0.0	-0.1
Medication: Amlodipine	0.0	0.1	0.1	0.2	0.3	-0.2
Myopia	0.0	0.0	0.0	-0.2	0.2	0.2
Cholesterol lowering medication	0.0	0.0	0.0	-0.1	0.2	-0.0

Hub : Genes

SLC4A2

Models

Trait associations