Best TWAS P=1.46e-25 · Best GWAS P=3.98e-17 conditioned to 0.0394
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EIF3E | 0.07 | 0.07 | bslmm | 401 | 0.09 | 1.5e-11 | -8.4 | 7.2 | 5.1e-13 | -0.84 | 0.02 | 0.98 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | RSPO2 | 0.12 | 0.10 | blup | 471 | 0.13 | 3.3e-15 | -7.4 | -10.5 | 1.5e-25 | 0.65 | 0.78 | 0.22 | TRUE |
| 3 | GTEx | Brain Caudate basal ganglia | EMC2 | 0.20 | 0.16 | lasso | 5 | 0.14 | 7.7e-05 | -5.4 | -5.2 | 1.8e-07 | 0.17 | 0.28 | 0.04 | FALSE |
| 4 | GTEx | Brain Cerebellum | EIF3E | 0.16 | 0.04 | lasso | 9 | 0.10 | 7.9e-04 | 7.6 | 5.3 | 1.2e-07 | -0.69 | 0.06 | 0.56 | FALSE |
| 5 | GTEx | Brain Cerebellum | EMC2 | 0.29 | 0.20 | lasso | 7 | 0.20 | 1.7e-06 | 4.5 | -6.3 | 2.5e-10 | 0.47 | 0.77 | 0.11 | FALSE |
| 6 | GTEx | Esophagus Mucosa | EMC2 | 0.19 | 0.20 | enet | 10 | 0.20 | 2.5e-13 | -6.3 | 6.3 | 2.8e-10 | -0.28 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Esophagus Muscularis | EMC2 | 0.25 | 0.15 | lasso | 5 | 0.14 | 4.3e-09 | -6.2 | -6.8 | 8.0e-12 | 0.37 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Muscle Skeletal | EMC2 | 0.05 | 0.04 | lasso | 3 | 0.02 | 2.7e-03 | 5.8 | 5.8 | 8.2e-09 | -0.52 | 0.71 | 0.01 | FALSE |
| 9 | GTEx | Skin Not Sun Exposed Suprapubic | EMC2 | 0.10 | 0.08 | lasso | 4 | 0.06 | 3.4e-04 | -6.3 | 5.8 | 8.2e-09 | -0.33 | 0.61 | 0.05 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | EMC2 | 0.12 | 0.08 | lasso | 3 | 0.06 | 7.0e-06 | -6.2 | 6.3 | 3.7e-10 | -0.31 | 0.98 | 0.00 | FALSE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TTC35 | 0.10 | 0.07 | lasso | 3 | 0.07 | 6.6e-08 | -6.7 | 6.5 | 7.8e-11 | -0.31 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TTC35 | 0.11 | 0.05 | blup | 52 | 0.04 | 2.1e-05 | -6.4 | -5.5 | 4.7e-08 | 0.28 | 0.01 | 0.98 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Adenocarcinoma | EIF3E | 0.02 | 0.01 | blup | 38 | 0.01 | 6.0e-02 | -8.4 | 8.2 | 1.6e-16 | -0.97 | 0.01 | 0.92 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EIF3E | 0.02 | 0.02 | blup | 38 | 0.01 | 1.5e-02 | -8.4 | 9.2 | 4.8e-20 | -0.93 | 0.01 | 0.90 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TTC35 | 0.04 | 0.02 | blup | 52 | 0.03 | 2.8e-04 | 5.7 | 6.7 | 1.8e-11 | -0.48 | 0.04 | 0.90 | FALSE |