Best TWAS P=3.15e-12 · Best GWAS P=1.16e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | GBAP1 | 0.10 | 0.10 | lasso | 3 | 0.08 | 6.1e-07 | 5.7 | 6.1 | 1.2e-09 | 0.97 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | GBA | 0.08 | 0.03 | lasso | 3 | 0.02 | 8.9e-03 | 5.7 | 5.4 | 5.7e-08 | 0.94 | 0.02 | 0.93 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | GBAP1 | 0.07 | 0.11 | enet | 5 | 0.10 | 5.0e-06 | 6.8 | 6.3 | 2.4e-10 | 0.99 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Artery Aorta | GBAP1 | 0.31 | 0.36 | enet | 22 | 0.39 | 1.0e-22 | 6.8 | 5.9 | 4.6e-09 | 0.94 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Artery Tibial | GBAP1 | 0.21 | 0.26 | lasso | 7 | 0.26 | 1.3e-20 | 6.8 | 6.1 | 9.2e-10 | 0.97 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Brain Cerebellar Hemisphere | THBS3 | 0.19 | 0.26 | lasso | 2 | 0.24 | 8.6e-07 | 6.5 | -6.6 | 5.5e-11 | -0.99 | 0.00 | 0.99 | FALSE |
| 7 | GTEx | Brain Cerebellar Hemisphere | EFNA1 | 0.33 | 0.04 | enet | 7 | 0.08 | 4.5e-03 | 5.7 | 5.4 | 7.6e-08 | 0.90 | 0.02 | 0.65 | FALSE |
| 8 | GTEx | Brain Cerebellum | THBS3 | 0.17 | 0.15 | enet | 6 | 0.16 | 2.0e-05 | 6.5 | -6.5 | 6.0e-11 | -0.90 | 0.01 | 0.98 | FALSE |
| 9 | GTEx | Brain Cerebellum | EFNA1 | 0.20 | 0.09 | enet | 13 | 0.06 | 9.2e-03 | -5.4 | 6.0 | 2.1e-09 | 0.90 | 0.02 | 0.96 | FALSE |
| 10 | GTEx | Brain Frontal Cortex BA9 | MTX1P1 | 0.20 | 0.05 | enet | 21 | 0.01 | 1.5e-01 | -5.3 | -6.2 | 7.4e-10 | -0.73 | 0.04 | 0.55 | FALSE |
| 11 | GTEx | Breast Mammary Tissue | GBAP1 | 0.15 | 0.17 | lasso | 2 | 0.15 | 5.2e-08 | 6.8 | 6.8 | 1.2e-11 | 1.00 | 0.00 | 1.00 | FALSE |
| 12 | GTEx | Breast Mammary Tissue (Female) | FAM189B | 0.05 | -0.01 | lasso | 2 | 0.00 | 4.8e-01 | -5.6 | 5.6 | 2.1e-08 | 0.66 | 0.03 | 0.27 | FALSE |
| 13 | GTEx | Cells Transformed fibroblasts | GBAP1 | 0.18 | 0.16 | lasso | 6 | 0.15 | 1.6e-11 | 6.8 | 5.8 | 5.0e-09 | 0.99 | 0.00 | 1.00 | FALSE |
| 14 | GTEx | Cells Transformed fibroblasts | SLC50A1 | 0.08 | 0.07 | lasso | 6 | 0.07 | 3.9e-06 | -5.4 | -5.6 | 1.9e-08 | -0.76 | 0.33 | 0.66 | FALSE |
| 15 | GTEx | Colon Sigmoid | GBAP1 | 0.16 | 0.13 | enet | 8 | 0.14 | 8.4e-06 | 6.8 | 7.0 | 3.2e-12 | 0.97 | 0.00 | 0.99 | TRUE |
| 16 | GTEx | Colon Transverse | GBAP1 | 0.13 | 0.15 | lasso | 5 | 0.11 | 6.4e-06 | 6.8 | 6.1 | 8.8e-10 | 0.99 | 0.00 | 1.00 | FALSE |
| 17 | GTEx | Colon Transverse | THBS3 | 0.11 | 0.09 | lasso | 4 | 0.09 | 5.9e-05 | 6.8 | -6.1 | 1.2e-09 | -0.95 | 0.01 | 0.99 | FALSE |
| 18 | GTEx | Esophagus Gastroesophageal Junction | GBAP1 | 0.22 | 0.19 | enet | 6 | 0.17 | 6.8e-07 | 5.7 | 5.8 | 8.4e-09 | 0.97 | 0.01 | 0.99 | FALSE |
| 19 | GTEx | Esophagus Mucosa | THBS3 | 0.15 | 0.15 | lasso | 2 | 0.13 | 6.8e-09 | 6.8 | -6.7 | 2.2e-11 | -1.00 | 0.00 | 1.00 | FALSE |
| 20 | GTEx | Esophagus Mucosa | MUC1 | 0.17 | 0.20 | lasso | 4 | 0.18 | 5.6e-12 | -6.3 | -6.4 | 1.3e-10 | -0.81 | 0.08 | 0.92 | FALSE |
| 21 | GTEx | Esophagus Mucosa | RP11-263K19.4 | 0.14 | 0.14 | lasso | 4 | 0.12 | 1.5e-08 | 6.8 | -6.7 | 1.9e-11 | -1.00 | 0.00 | 1.00 | FALSE |
| 22 | GTEx | Esophagus Muscularis | GBAP1 | 0.09 | 0.13 | enet | 4 | 0.12 | 8.9e-08 | 5.7 | 6.3 | 2.5e-10 | 0.99 | 0.00 | 1.00 | FALSE |
| 23 | GTEx | Lung | GBAP1 | 0.16 | 0.16 | lasso | 5 | 0.15 | 1.6e-11 | 5.7 | 5.8 | 5.5e-09 | 0.96 | 0.02 | 0.98 | FALSE |
| 24 | GTEx | Lung | THBS3 | 0.11 | 0.07 | lasso | 4 | 0.04 | 1.0e-03 | 6.8 | -6.7 | 1.6e-11 | -0.99 | 0.00 | 1.00 | FALSE |
| 25 | GTEx | Nerve Tibial | GBAP1 | 0.12 | 0.14 | lasso | 1 | 0.14 | 8.9e-10 | 6.8 | 6.8 | 1.4e-11 | 1.00 | 0.00 | 1.00 | FALSE |
| 26 | GTEx | Nerve Tibial | GBA | 0.14 | 0.02 | lasso | 5 | 0.01 | 3.3e-02 | 6.8 | 5.7 | 1.2e-08 | 0.96 | 0.01 | 0.99 | FALSE |
| 27 | GTEx | Pancreas | THBS3 | 0.36 | 0.14 | lasso | 6 | 0.12 | 1.0e-05 | 6.5 | -6.3 | 3.7e-10 | -0.90 | 0.01 | 0.98 | FALSE |
| 28 | GTEx | Pancreas | GBA | 0.12 | 0.05 | enet | 10 | 0.02 | 4.2e-02 | 6.8 | 5.5 | 3.9e-08 | 0.90 | 0.01 | 0.96 | FALSE |
| 29 | GTEx | Prostate | GBAP1 | 0.47 | 0.30 | lasso | 7 | 0.32 | 1.1e-08 | 6.8 | 6.5 | 6.7e-11 | 0.96 | 0.01 | 0.99 | FALSE |
| 30 | GTEx | Skin Not Sun Exposed Suprapubic | GBAP1 | 0.15 | 0.06 | lasso | 4 | 0.06 | 3.6e-04 | -6.2 | 6.8 | 9.7e-12 | 0.91 | 0.01 | 0.98 | FALSE |
| 31 | GTEx | Skin Sun Exposed Lower leg | RP11-263K19.4 | 0.04 | 0.01 | enet | 9 | 0.01 | 3.3e-02 | 6.8 | -6.0 | 1.5e-09 | -0.98 | 0.01 | 0.97 | FALSE |
| 32 | GTEx | Small Intestine Terminal Ileum | GBAP1 | 0.20 | 0.13 | lasso | 10 | 0.11 | 1.8e-03 | -5.3 | 6.5 | 1.0e-10 | 0.93 | 0.02 | 0.90 | FALSE |
| 33 | GTEx | Spleen | THBS3 | 0.23 | 0.10 | enet | 17 | 0.08 | 4.6e-03 | -4.6 | -5.4 | 6.2e-08 | -0.80 | 0.04 | 0.85 | FALSE |
| 34 | GTEx | Testis | THBS3 | 0.11 | 0.11 | lasso | 2 | 0.09 | 1.2e-04 | 5.7 | -6.0 | 2.5e-09 | -0.96 | 0.01 | 0.99 | FALSE |
| 35 | GTEx | Testis | RP11-263K19.4 | 0.08 | 0.12 | lasso | 2 | 0.10 | 2.4e-05 | 5.7 | -5.8 | 6.6e-09 | -0.95 | 0.01 | 0.98 | FALSE |
| 36 | GTEx | Thyroid | GBAP1 | 0.23 | 0.28 | lasso | 10 | 0.27 | 4.6e-21 | 6.5 | 6.4 | 1.8e-10 | 0.99 | 0.00 | 1.00 | FALSE |
| 37 | GTEx | Thyroid | THBS3 | 0.12 | 0.09 | enet | 8 | 0.09 | 3.6e-07 | 5.7 | -5.4 | 7.3e-08 | -0.87 | 0.01 | 0.99 | FALSE |
| 38 | GTEx | Thyroid | MUC1 | 0.11 | 0.02 | enet | 15 | 0.09 | 1.5e-07 | 2.2 | 5.4 | 5.4e-08 | 0.62 | 0.29 | 0.71 | FALSE |
| 39 | GTEx | Whole Blood | THBS3 | 0.17 | 0.20 | enet | 5 | 0.21 | 1.0e-18 | 6.8 | -6.4 | 1.2e-10 | -0.99 | 0.00 | 1.00 | FALSE |
| 40 | GTEx | Whole Blood | RP11-263K19.4 | 0.15 | 0.17 | lasso | 4 | 0.17 | 9.5e-16 | 6.8 | -6.3 | 2.5e-10 | -0.99 | 0.00 | 1.00 | FALSE |
| 41 | YFS | Blood | THBS3 | 0.29 | 0.22 | enet | 38 | 0.31 | 6.4e-105 | 6.8 | -5.2 | 1.7e-07 | -0.85 | 0.00 | 1.00 | FALSE |
| 42 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TRIM46 | 0.03 | 0.00 | blup | 33 | 0.02 | 3.6e-03 | -6.3 | -6.3 | 2.7e-10 | -0.85 | 0.02 | 0.47 | FALSE |
| 43 | The Cancer Genome Atlas | Breast Invasive Carcinoma | THBS3 | 0.02 | 0.02 | blup | 26 | 0.02 | 4.0e-05 | 6.5 | -5.9 | 3.6e-09 | -0.93 | 0.00 | 0.99 | FALSE |
| 44 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | GBAP1 | 0.10 | 0.06 | enet | 9 | 0.04 | 5.1e-03 | 6.8 | 6.0 | 2.0e-09 | 0.89 | 0.00 | 0.84 | FALSE |
| 45 | The Cancer Genome Atlas | Esophageal Carcinoma | FAM189B | 0.36 | 0.05 | lasso | 3 | 0.02 | 6.1e-02 | 6.8 | 6.7 | 2.0e-11 | 1.00 | 0.00 | 0.66 | FALSE |
| 46 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MUC1 | 0.04 | 0.01 | enet | 4 | 0.02 | 1.3e-03 | -6.3 | -5.9 | 3.7e-09 | -0.78 | 0.01 | 0.78 | FALSE |
| 47 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | THBS3 | 0.02 | 0.03 | lasso | 4 | 0.03 | 2.1e-04 | 6.8 | -6.9 | 6.0e-12 | -0.99 | 0.00 | 0.99 | FALSE |
| 48 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GBAP1 | 0.03 | 0.01 | blup | 26 | 0.02 | 1.9e-03 | -5.4 | 6.4 | 1.3e-10 | 0.91 | 0.02 | 0.90 | FALSE |
| 49 | The Cancer Genome Atlas | Lung Adenocarcinoma | GBAP1 | 0.02 | 0.03 | enet | 2 | 0.02 | 2.3e-03 | 6.8 | 6.8 | 1.2e-11 | 1.00 | 0.00 | 0.95 | FALSE |
| 50 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | GBAP1 | 0.05 | 0.04 | blup | 26 | 0.04 | 1.6e-03 | 6.8 | 5.5 | 4.1e-08 | 0.91 | 0.00 | 0.94 | FALSE |
| 51 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TRIM46 | 0.08 | 0.08 | lasso | 2 | 0.07 | 2.1e-05 | 6.8 | -6.8 | 1.4e-11 | -1.00 | 0.00 | 0.99 | FALSE |
| 52 | The Cancer Genome Atlas | Prostate Adenocarcinoma | THBS3 | 0.10 | 0.12 | enet | 11 | 0.10 | 4.4e-11 | 6.5 | -6.4 | 2.0e-10 | -0.98 | 0.00 | 1.00 | FALSE |