TWAS hub - SLC50A1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.082	0.0330	0.00049	0.067	NA	0.069	NA	0.073	8.8e-06	NA	7.2e-06	NA	3.9e-06
2	ROSMAP	Brain Pre-frontal Cortex	0.063	0.0227	0.00022	0.018	0.032	0.026	0.032	0.032	1.9e-03	5.1e-05	2.2e-04	4.3e-05	4.7e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Mouth/teeth dental problems: Dentures	17.3	29.2	32.6	5.7	5.1
Gout (self-reported)	15.5	21.3	29.2	-3.7	-5.4
Medication: Allopurinol	14.3	19.1	29.4	-3.0	-5.4
Mouth/teeth dental problems	13.3	20.4	27.7	-5.3	-3.6
Impedance of leg (left)	13.2	64.0	74.8	7.3	8.7
Impedance of leg (right)	12.6	61.1	69.1	7.3	8.3
Smoking status: Previous	10.4	15.6	26.0	5.1	2.3
Leg fat-free mass (right)	9.3	49.8	63.8	-6.0	-8.0
Blood Red Count	9.1	88.3	106.1	8.4	10.3
Leg predicted mass (right)	9.1	48.7	62.4	-5.9	-7.9
Leg fat-free mass (left)	8.9	47.1	61.9	-5.7	-7.9
Leg predicted mass (left)	8.8	46.3	61.0	-5.6	-7.8
Past tobacco smoking	7.5	13.7	23.3	-4.8	-2.0
Basal metabolic rate	7.1	39.5	56.1	-4.8	-7.5
Impedance of whole body	6.8	34.6	52.6	4.1	7.2
Weight	6.7	32.8	41.7	-4.9	-6.5
Whole body water mass	6.7	38.1	56.4	-4.5	-7.5
Irritable Bowel Disease (IBD)	6.6	15.7	29.1	5.4	1.5
Breast Cancer	6.6	15.8	23.8	-4.9	-2.8
Whole body fat-free mass	6.5	36.9	54.2	-4.4	-7.4
Allergy	6.2	14.2	14.7	-3.8	-3.7
Arm fat mass (left)	6.1	24.9	26.7	-4.8	-5.2
Depressed Affect (Nagel 2018)	5.9	12.4	17.4	4.2	2.7
Illnesses of father: Heart disease	5.9	8.2	8.8	-3.0	-2.7
Ulcerative Colitis (UC)	5.5	10.4	17.1	4.1	1.9
Blood Platelet Count	5.5	63.2	65.8	8.1	7.8
Allergy or Eczema	5.5	14.4	18.2	3.3	4.3
Hayfever, allergic rhinitis or eczema	5.4	11.7	12.0	3.4	3.5
Body mass index (BMI)	5.4	22.9	25.7	-4.5	-5.1
Arm fat mass (right)	5.4	22.4	23.1	-4.7	-4.8
Trunk fat-free mass	5.3	30.4	47.3	-3.7	-6.9
Hip circumference	5.3	22.9	28.7	-4.1	-5.4
Knee pain experienced in last month	5.3	8.2	10.2	-2.5	-3.2
Trunk predicted mass	5.2	29.6	46.5	-3.5	-6.8
Arm fat-free mass (left)	5.1	25.9	42.6	-3.0	-6.5
Arm predicted mass (left)	5.0	25.2	42.9	-2.8	-6.5
Heel bone mineral density (BMD) T-score, automated (left)	4.9	11.1	11.2	-3.4	-3.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.9	5.9	7.0	2.6	2.2
Bipolar Disorder (2018)	4.8	7.5	10.7	2.1	3.3
Arm predicted mass (right)	4.8	24.7	42.0	-2.7	-6.5
Eye problems/disorders: None of the above	4.6	5.3	6.2	-2.5	-2.1
Risk taking	4.6	6.8	8.4	2.3	2.9
Crohns Disease (2017)	4.4	9.6	18.6	4.3	0.8
Miserableness	4.3	7.4	11.0	3.3	1.9
Medication: Atorvastatin	4.3	5.4	8.2	2.9	1.6
Arm fat-free mass (right)	4.2	21.6	37.5	-2.4	-6.1
High blood pressure (mother)	4.1	5.7	10.6	-3.2	-1.0
Waist Hip Ratio (WHR)	4.0	18.2	19.4	4.1	4.4
Medication: Gliclazide	4.0	4.6	8.6	2.9	0.7
Hayfever/allergic rhinitis (self-reported)	3.9	5.2	6.6	1.9	2.6
Arm fat percentage (left)	3.9	15.6	20.2	-4.5	-3.3
Commuting to job workplace: Public transport	3.8	4.5	5.3	-1.9	-2.3
Fed-up feelings	3.7	6.8	10.6	3.3	1.7
Heel bone mineral density (BMD) T-score, automated (right)	3.7	8.5	10.0	-2.6	-3.2
Emphysema/chronic bronchitis	3.7	4.2	5.6	2.4	1.7
Pulse wave reflection index	3.6	4.5	6.8	2.6	1.4
Mood swings	3.6	6.6	10.0	3.2	1.8
Medication: Aspirin	3.6	4.6	7.8	1.2	2.8
Had other major operations	3.5	4.3	6.4	-1.4	-2.5
Whole body fat mass	3.5	14.7	16.0	-3.7	-4.0
Back pain experienced in last month	3.5	5.1	5.6	-2.4	-2.1
Neuroticism	3.4	8.2	8.9	3.0	2.8
Lung FVC	3.3	17.0	19.8	-3.8	-4.5
Diabetes (self-reported)	3.3	5.2	5.2	2.3	2.2
Arm fat percentage (right)	3.3	13.2	18.1	-4.3	-2.9
Loneliness, isolation	3.3	4.5	7.8	2.8	1.1
Crohns Disease (2012)	3.2	5.2	10.2	3.2	0.4
BMI	3.2	18.8	20.8	-4.1	-4.6
Medication: Omeprazole	3.2	3.9	4.8	2.2	1.7
Heel T-Score	3.1	24.3	31.6	-5.6	-4.1
Bilateral oophorectomy (both ovaries removed)	3.1	3.6	4.4	-1.7	-2.1
Trunk fat mass	3.1	13.4	14.2	-3.8	-3.5
Hair/balding pattern: Pattern 4	3.1	7.6	8.0	-2.8	-2.7
Alzheimer’s Disease (in father)	3.0	3.3	4.0	-1.6	-2.0
Medication: Ventolin 100micrograms inhaler	3.0	3.9	4.6	1.8	2.1
Wheeze or whistling in the chest in last year	2.9	5.2	8.8	3.0	1.2
Medication: Aspirin	2.9	3.9	6.8	1.0	2.6
Impedance of arm (right)	2.8	13.1	25.5	0.8	5.0
Ever smoked	2.7	4.8	9.5	3.1	0.2
Ulcerative Colitis	2.6	3.7	7.0	2.6	0.6
Pain experienced in last month	2.6	4.3	7.7	2.8	0.9
Leg fat mass (left)	2.6	10.0	13.7	-2.5	-3.7
Age at First Birth	2.5	3.7	3.8	-2.0	-1.9
Ever used hormone-replacement therapy (HRT)	2.5	3.2	5.5	-2.3	-1.0
Hearing difficulty/problems with background noise	2.5	4.0	6.1	1.4	2.5
Forced expiratory volume in 1-second (FEV1)	2.5	8.4	10.3	-2.6	-3.2
Asthma	2.5	5.0	6.6	1.8	2.6
Impedance of arm (left)	2.4	11.1	22.0	0.5	4.7
Hypothyroidism/myxoedema (self-reported)	2.4	4.7	5.9	-1.9	-2.4
LDL Cholesterol	2.3	3.6	7.2	2.7	0.0
Type 2 Diabetes (T2D) (2018)	2.3	4.3	6.9	2.6	1.3
Happiness	2.3	2.8	3.4	1.5	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	2.3	7.3	10.0	-2.1	-3.2
Leg fat mass (right)	2.3	8.9	12.7	-2.3	-3.6
Number of full sisters	2.3	2.8	5.3	-0.6	-2.3
Asthma (self-reported)	2.3	4.6	5.9	1.8	2.4
High cholesterol (Self-reported)	2.3	4.1	6.0	2.5	1.5
Frequency of depressed mood in last 2 weeks	2.2	3.1	5.1	2.2	1.1
Forced vital capacity (FVC)	2.2	8.5	12.5	-2.1	-3.5
Mouth/teeth dental problems: Bleeding gums	2.2	2.9	5.7	2.4	-0.3
Chest pain or discomfort	2.2	3.1	5.9	2.4	0.6
Neuroticism (Nagel 2018)	2.1	4.8	5.3	2.3	2.1
Hypothyroidism (self reported)	2.1	4.7	6.0	-1.9	-2.5
Systolic blood pressure, automated reading	2.1	6.1	8.3	-2.9	-2.0
Medication: Cholesterol lowering	2.1	3.3	5.0	2.2	1.2
Lung cancer (father)	2.1	2.5	3.0	1.4	1.7
Illnesses of mother	2.1	2.6	3.8	1.2	2.0
Blood clot in the leg (DVT)	2.1	2.7	4.4	2.1	1.0
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	4.3	2.1	1.1
Body Mass Index (BMI) (2010)	2.0	2.7	4.5	-2.1	-1.0
Medication: Metformin	2.0	2.9	3.1	1.8	1.6
Waist circumference	2.0	7.4	10.9	-2.0	-3.3
Pulse wave peak to peak time	2.0	2.4	2.7	-1.4	-1.6
Had major operations	2.0	2.3	2.9	1.3	1.7
Supplements: Vitamin C	2.0	2.3	4.0	0.8	2.0
Bipolar Disorder or Schizophrenia	1.9	4.6	7.1	1.4	2.7
Medication for hormone replacement therapy	1.9	2.1	2.8	-1.7	-1.2
Hair/balding pattern: Pattern 3	1.9	2.8	5.1	0.7	2.3
Medication for cholesterol, blood pressure or diabetes	1.9	3.2	5.6	-2.4	-0.9
Forced vital capacity (FVC), Best measure	1.9	7.0	11.2	-1.6	-3.4
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.1	2.3	1.5	1.4
Neuroticism score	1.8	3.8	5.5	2.4	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	4.5	2.1	0.2
Diabetes diagnosed by doctor	1.8	3.0	4.8	2.2	1.1
Ever taken oral contraceptive pill	1.8	2.0	3.9	0.0	2.0
Diastolic blood pressure, automated reading	1.8	5.7	9.7	-3.1	-1.3
Height	1.7	32.7	49.7	-4.0	-7.0
Stomach or abdominal pain in last month	1.7	2.1	3.3	0.9	1.8
Pulse wave Arterial Stiffness index	1.7	2.0	2.1	1.4	1.5
Peak expiratory flow (PEF)	1.7	4.0	7.2	-2.7	-0.9
Mouth/teeth dental problems: Loose teeth	1.7	2.0	2.2	1.5	1.3
Family relationship satisfaction	1.7	2.1	2.6	1.6	1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.5	6.9	-0.5	-2.6
Illnesses of father: None of the above (group 1)	1.7	2.1	2.2	1.5	1.4
Wears glasses or contact lenses	1.7	1.9	3.9	-0.1	2.0
Trunk fat percentage	1.6	6.4	9.6	-3.1	-1.8
Qualifications: CSEs or equivalent	1.6	2.1	3.7	0.7	-1.9
Tense / ‘highly strung’	1.6	2.6	3.7	1.9	1.3
Worry too long after embarrassment	1.6	2.8	3.1	1.6	1.8
Commuting to job workplace: Car/motor vehicle	1.6	1.8	2.2	1.2	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	3.7	-1.9	-1.8
Average weekly champagne plus white wine intake	1.6	2.2	2.9	-1.7	-1.2
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	2.6	1.6	1.1
Depression (Nagel 2018)	1.5	2.3	3.4	1.8	1.1
Supplements: Glucosamine	1.5	1.9	3.7	-1.9	0.4
Nervous feelings	1.5	2.9	4.1	-2.0	-1.3
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	3.4	-1.8	0.6
Sensitivity / hurt feelings	1.4	2.4	3.6	1.1	1.9
Medication: Lansoprazole	1.4	1.6	2.2	1.5	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	1.8	-1.3	-1.3
Age started oral contraceptive pill	1.4	1.8	3.6	-0.1	1.9
Prostate Cancer	1.3	1.9	2.2	1.3	1.5
Mean Putamen Volume	1.3	1.5	3.0	1.7	0.3
Ever had hysterectomy (womb removed)	1.3	1.5	2.1	-1.4	-0.9
Medication for pain relief, constipation, heartburn	1.3	2.3	4.5	0.2	-2.1
Eye problems/disorders: Cataract	1.3	1.5	2.3	1.5	0.8
Irritability	1.3	2.2	3.8	1.9	0.8
Supplements: Calcium	1.3	1.4	1.5	1.2	1.2
Hair Pigment	1.2	32.9	55.2	7.4	3.2
Townsend deprivation index at recruitment	1.2	1.7	2.6	1.6	-0.9
Prospective memory result	1.2	1.5	1.8	-1.3	-1.1
Loud music exposure frequency	1.2	1.3	1.9	-1.4	-0.8
Body fat percentage	1.2	4.8	6.8	-2.6	-1.7
Number of full brothers	1.2	1.5	1.7	1.1	-1.3
Commuting to job workplace: Cycle	1.2	1.5	2.9	0.4	1.7
Schizophrenia vs Biploar Disorder	1.1	1.5	2.4	-0.7	-1.5
Fasting Glucose	1.1	1.3	2.5	1.6	0.5
Smoking Status	1.1	2.7	4.7	2.2	0.9
Respiratory disease	1.1	2.5	3.2	1.8	1.4
Average weekly spirits intake	1.1	1.4	2.6	-1.6	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.0	1.7	0.2
Medication: Atenolol	1.1	1.4	1.8	-1.3	-1.0
Number of live births	1.1	1.6	2.3	1.5	1.0
Medication: Blood pressure	1.1	1.9	3.5	1.9	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	1.7	0.9	1.3
Financial situation satisfaction	1.1	1.3	2.5	1.6	-0.3
Alzheimer’s Disease (including proxy)	1.0	1.4	2.3	-0.7	-1.5
Blood Eosinophil Count	1.0	7.7	14.4	1.0	3.8
Hearing difficulty/problems: Yes	1.0	1.5	3.0	0.2	1.7
Relative age of first facial hair	1.0	2.1	3.9	-0.6	-2.0
Diabetes (father)	1.0	1.2	1.9	-0.7	-1.4
Pack years adult smoking proportion	1.0	1.6	2.1	-1.4	-1.0
Breastfed as a baby	1.0	1.2	2.0	0.7	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	2.4	-0.9	-1.5
Medication: Ibuprofen	1.0	1.2	1.7	-1.3	0.8
Primary Biliary Cirrhosis	0.9	1.3	2.5	-0.2	-1.6
Rheumatoid Arthritis	0.9	1.2	1.3	1.1	1.1
Multivitamins +/- minerals	0.9	1.1	2.2	-1.5	-0.3
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	1.2	-1.0	-1.1
Time employed in main current job	0.9	1.0	2.0	-1.4	0.1
Medication: Seretide 50 evohaler	0.9	1.0	2.0	1.4	0.2
Commuting to job workplace: Walk	0.9	1.0	1.2	-1.1	-0.9
Mother’s age at death	0.9	1.1	2.2	0.1	1.5
HbA1C	0.8	0.9	1.7	1.3	0.4
Tanning	0.8	9.6	10.1	3.2	3.0
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.2	0.9	1.1
Serious illness, injury or assault to yourself	0.8	1.0	1.2	0.9	1.1
Medication: Ramipril	0.8	1.0	1.9	1.4	-0.1
Noisy workplace	0.8	1.0	1.5	0.7	1.2
Ever highly irritable/argumentative for 2 days	0.8	1.0	1.9	-0.2	-1.4
Birth weight	0.8	1.8	3.4	-0.5	-1.8
Number of children fathered	0.8	0.9	1.5	-1.2	-0.6
Qualifications: College or University degree	0.8	2.6	4.3	-0.9	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.7	-1.3	0.4
Coronary Artery Disease (CAD)	0.7	0.8	1.0	-0.8	1.0
Severe depression (siblings)	0.7	0.8	1.3	1.1	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	1.6	1.3	-0.7
Qualifications: None of the above	0.7	1.5	3.0	0.0	-1.7
Father’s age at death	0.7	0.9	1.0	1.0	0.9
Standing height	0.7	7.3	12.3	-1.5	-3.5
Average weekly red wine intake	0.7	1.0	2.0	0.3	1.4
Long-standing illness, disability or infirmity	0.7	1.1	1.7	1.3	0.7
Ever had bowel cancer screening	0.7	0.8	1.7	-0.0	-1.3
Number of self-reported non-cancer illnesses	0.7	1.2	1.4	1.2	1.0
Illnesses of father: High blood pressure	0.7	0.9	1.8	0.0	1.4
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.2	1.1	0.4
Chronotype (morning person)	0.6	1.3	2.0	1.4	0.7
Average weekly fortified wine intake	0.6	0.7	1.4	-1.2	0.1
Medication: Levothyroxine sodium	0.6	1.1	1.6	-0.7	-1.3
Hair/balding pattern: Pattern 2	0.6	0.7	1.4	1.2	-0.0
Fluid intelligence score	0.6	1.3	1.9	-0.9	-1.4
Headache pain in last month	0.6	1.0	1.9	0.1	1.4
High blood pressure (siblings)	0.6	0.8	1.6	-1.3	-0.1
Comparative height size at age 10	0.6	3.3	4.6	-1.4	-2.1
Age at last live birth	0.6	0.9	1.6	0.3	1.3
Leg pain on walking	0.6	0.7	1.3	-0.3	-1.1
Friendships satisfaction	0.6	0.7	1.4	0.2	1.2
Alcohol drinker status: Never	0.6	0.7	1.4	-1.2	0.3
Average weekly beer plus cider intake	0.6	0.9	1.8	0.2	-1.3
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.3	-1.1	-0.0
Unable to work because of sickness or disability	0.6	0.7	1.5	0.2	-1.2
Basal cell carcinoma (self-reported)	0.6	0.7	1.1	-0.6	1.0
Alzheimer’s Disease (in mother)	0.5	0.6	1.0	1.0	-0.3
Neuroticism (2016)	0.5	0.7	1.3	0.0	1.1
Blood White Count	0.5	3.8	4.6	2.1	1.7
Angina	0.5	0.7	1.1	0.4	1.1
Hand grip strength (right)	0.5	1.3	2.4	-0.5	-1.6
Relative age voice broke	0.5	0.7	1.2	-0.5	-1.1
Chronic bronchitis/emphysema (father)	0.5	0.6	1.1	0.3	-1.1
Number of incorrect matches in round	0.5	0.9	1.4	-1.2	-0.6
Alcohol usually taken with meals	0.5	0.8	1.7	0.1	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.0	1.0	-0.8
Medication: Amlodipine	0.5	0.7	0.9	0.7	0.9
Angina (self-reported)	0.5	0.7	1.2	0.4	1.1
Pulse rate, automated reading	0.5	1.6	2.8	-0.6	1.7
Medication for cholesterol	0.5	0.7	1.4	1.2	-0.0
Medication: Blood pressure	0.5	0.9	1.7	-1.3	-0.3
Alcohol drinker status: Previous	0.5	0.5	0.6	0.8	-0.7
Pack years of smoking	0.5	0.7	0.9	-0.9	-0.7
Intelligence (Savage-Jansen 2018)	0.4	1.2	1.8	-0.8	-1.4
Verbal and Numeric Reasoning (VNR)	0.4	1.1	1.7	-0.7	-1.3
Hand grip strength (left)	0.4	1.0	1.9	0.4	-1.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.8	-0.9	0.2
Vitamin and mineral supplements	0.4	0.6	1.1	1.1	0.2
Diabetes (mother)	0.4	0.5	0.6	0.6	-0.8
Current tobacco smoking	0.4	0.7	1.4	-0.2	-1.2
Illnesses of siblings	0.4	0.6	0.8	0.9	0.6
Pulse rate	0.4	0.7	1.4	-0.2	1.2
Length of working week for main job	0.4	0.4	0.9	0.9	-0.0
Birth weight of first child	0.4	0.8	1.5	-0.4	-1.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	0.7	-0.8	0.9
Leg fat percentage (right)	0.4	1.5	2.2	-0.9	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.0	1.0	-0.3
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.7	-0.5	0.8
Eye problems/disorders: Glaucoma	0.4	0.4	0.8	0.3	0.9
Leg fat percentage (left)	0.4	1.5	1.9	-1.0	-1.4
Heart disease (siblings)	0.4	0.5	0.7	-0.8	-0.6
Ovarian Cancer	0.3	0.4	0.5	0.7	0.6
Number of treatments/medications taken	0.3	0.5	0.9	0.3	0.9
Maternal smoking around birth	0.3	0.4	0.6	-0.4	-0.8
Age when periods started (menarche)	0.3	0.7	1.1	1.0	0.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.8	0.1	-0.9
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.6	0.4	-0.8
Comparative body size at age 10	0.3	0.9	1.7	-1.3	-0.3
Health satisfaction	0.3	0.4	0.7	-0.3	-0.8
Overall health rating	0.3	0.7	1.3	0.2	-1.1
Qualifications: nursing, teaching	0.3	0.5	0.5	-0.7	0.7
Mineral and other dietary supplements	0.3	0.4	0.8	0.9	-0.3
Osteoporosis (self-reported)	0.3	0.4	0.7	0.9	-0.1
Osteoarthritis (self-reported)	0.3	0.4	0.8	-0.0	-0.9
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.6	-0.8	0.4
Medication: Paracetamol	0.3	0.5	0.9	0.3	0.9
Fractured/broken bones in last 5 years	0.3	0.4	0.4	0.6	0.6
Schizophrenia (2018)	0.2	0.4	0.7	0.2	0.8
HDL Cholesterol	0.2	0.3	0.4	-0.6	0.4
Triglycerides	0.2	0.4	0.7	0.8	-0.1
Lung FEV1/FVC ratio	0.2	0.8	1.4	-0.5	1.2
Medication: Co-codamol	0.2	0.2	0.2	-0.4	-0.5
Sitting height	0.2	1.1	1.5	0.8	-1.2
Pain all over the body in last month	0.2	0.2	0.4	0.2	0.7
Alcohol intake versus 10 years previously	0.2	0.3	0.6	0.3	-0.8
Worrier / anxious feelings	0.2	0.4	0.9	-0.1	0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.7	0.3	0.8
Depression (self-reported)	0.2	0.2	0.3	0.6	-0.2
Medication: Paracetamol	0.2	0.3	0.6	0.0	0.8
Age at first live birth	0.2	0.4	0.6	-0.3	0.8
Migraine (self-reported)	0.2	0.2	0.3	-0.5	0.5
Smoking status: Current	0.2	0.4	0.6	-0.4	-0.8
Guilty feelings	0.2	0.2	0.5	0.1	-0.7
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.2	0.5	-0.4
Ever depressed for a whole week	0.2	0.2	0.2	-0.4	-0.5
Cholesterol lowering medication	0.2	0.3	0.5	0.7	0.4
Worry (Nagel 2018)	0.1	0.2	0.4	-0.6	0.0
Major Depression (MDD)	0.1	0.1	0.3	0.5	0.1
Reaction Time	0.1	0.2	0.2	0.3	-0.5
Lupus	0.1	0.1	0.1	-0.2	-0.4
Schizophrenia (2014)	0.1	0.2	0.4	-0.0	0.7
Systolic Blood Pressure	0.1	0.3	0.3	-0.6	0.5
Cardiovascular Disease	0.1	0.2	0.4	0.7	0.1
Supplements: Zinc	0.1	0.1	0.1	0.4	0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.2	0.4	0.4
Had menopause	0.1	0.1	0.2	-0.5	0.1
Medication: Simvastatin	0.1	0.1	0.3	0.5	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	0.3	-0.3
Exposure to tobacco smoke outside home	0.1	0.1	0.2	-0.2	0.5
Mean time to correctly identify matches	0.1	0.3	0.4	0.6	0.4
Heart disease (mother)	0.1	0.1	0.1	-0.3	-0.3
Illnesses of siblings: Diabetes	0.1	0.1	0.1	-0.3	-0.3
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.3	-0.6	0.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.2	-0.4	-0.5
Medication: Bendroflumethiazide	0.1	0.2	0.3	-0.1	0.6
Medication: Lisinopril	0.1	0.1	0.2	-0.2	0.4
Number of operations (self-reported)	0.1	0.1	0.1	0.2	-0.3
Myopia	0.1	0.1	0.2	0.1	0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Taking other prescription medications	0.0	0.0	0.0	-0.2	-0.1
High blood pressure	0.0	0.1	0.2	-0.2	-0.4
Financial difficulties in last 2 years	0.0	0.0	0.0	-0.1	-0.1
Heart attack	0.0	0.0	0.0	0.1	0.1
Falls in the last year	0.0	0.0	0.0	0.2	0.0
Exposure to tobacco smoke at home	0.0	0.0	0.0	-0.2	-0.2
Glaucoma (self-reported)	0.0	0.0	0.0	0.2	-0.1
Shortness of breath walking on level ground	0.0	0.0	0.0	-0.0	0.1
Neck or shoulder pain in last month	0.0	0.0	0.1	-0.0	-0.3
Alcohol intake frequency.	0.0	0.0	0.1	-0.3	0.1
Suffer from ‘nerves’	0.0	0.0	0.0	0.0	-0.2
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	-0.1	-0.1
Hypertension (Self-reported)	0.0	0.1	0.2	0.3	-0.4
Breast cancer (self-reported)	0.0	0.0	0.0	0.1	-0.2
Hearing aid user	0.0	0.0	0.0	0.1	-0.1
Vascular/heart problems diagnosed by doctor	0.0	0.0	0.1	0.1	0.2
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	-0.1	-0.0

Hub : Genes

SLC50A1

Models

Trait associations