[Hub]/) : Traits : Heel T-Score : ← →

chr11:117,707,229-120,898,253

Best TWAS P=2.88e-39 · Best GWAS P=7.32e-38 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Aorta	TMEM25	0.12	0.09	enet	29	0.03	5.1e-03	2.1	-5.2	1.7e-07	0.19	0.79	0.01	FALSE
2	GTEx	Brain Cerebellar Hemisphere	PHLDB1	0.27	0.00	enet	43	0.08	3.7e-03	-12.8	-7.8	5.2e-15	0.45	0.03	0.66	FALSE
3	GTEx	Brain Cerebellum	PHLDB1	0.32	0.17	lasso	7	0.20	1.4e-06	6.7	-11.2	6.6e-29	0.77	0.04	0.90	FALSE
4	GTEx	Brain Frontal Cortex BA9	TMEM25	0.22	0.13	lasso	4	0.14	1.6e-04	2.4	-5.1	2.8e-07	0.30	0.17	0.24	FALSE
5	GTEx	Cells Transformed fibroblasts	DDX6	0.12	0.08	lasso	5	0.10	1.2e-07	7.2	6.7	2.9e-11	-0.40	0.98	0.01	FALSE
6	GTEx	Cells Transformed fibroblasts	NLRX1	0.15	0.02	enet	30	0.01	6.2e-02	-4.9	-5.2	1.7e-07	0.03	0.18	0.05	FALSE
7	GTEx	Colon Sigmoid	TMEM136	0.18	0.02	lasso	2	0.03	4.4e-02	-6.3	-5.9	4.1e-09	0.03	0.03	0.94	FALSE
8	GTEx	Colon Sigmoid	CCDC153	0.18	0.02	enet	18	0.14	8.0e-06	-7.3	7.4	1.2e-13	-0.48	0.02	0.79	FALSE
9	GTEx	Nerve Tibial	TMEM136	0.23	0.19	lasso	6	0.23	1.4e-16	-3.2	-5.2	1.7e-07	0.03	0.08	0.92	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	AP002954.3	0.07	0.01	bslmm	256	0.02	7.1e-04	2.3	6.9	4.3e-12	-0.46	0.02	0.91	FALSE
11	YFS	Blood	CBL	0.10	0.05	lasso	8	0.09	2.3e-28	-4.8	5.4	5.4e-08	0.00	1.00	0.00	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	CBL	0.03	0.03	lasso	4	0.03	2.8e-07	-4.8	5.5	3.4e-08	0.00	0.01	0.98	TRUE
13	The Cancer Genome Atlas	Colon Adenocarcinoma	ARHGEF12	0.08	0.05	blup	110	0.06	2.9e-04	-6.2	-6.0	1.4e-09	0.06	0.02	0.96	TRUE
14	The Cancer Genome Atlas	Colon Adenocarcinoma	TREH	0.21	0.09	blup	14	0.09	1.2e-05	-11.9	13.1	2.9e-39	-0.98	0.00	1.00	TRUE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM136	0.05	0.03	blup	45	0.05	7.2e-06	-2.9	-6.0	2.7e-09	0.04	0.01	0.98	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TREH	0.07	0.05	lasso	1	0.05	6.7e-06	-11.9	11.9	1.7e-32	-0.95	0.00	1.00	FALSE
17	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TREH	0.14	0.07	blup	15	0.07	1.3e-04	-11.9	11.8	5.3e-32	-0.94	0.00	0.98	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	PHLDB1	0.15	0.11	lasso	4	0.17	9.3e-19	6.4	10.2	1.7e-24	-0.81	0.02	0.98	FALSE
19	The Cancer Genome Atlas	Brain Lower Grade Glioma	TREH	0.06	0.01	blup	15	0.02	5.3e-03	4.8	8.7	2.7e-18	-0.61	0.01	0.29	FALSE
20	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TREH	0.28	0.25	lasso	1	0.24	1.5e-10	-11.9	11.9	1.7e-32	-0.95	0.00	1.00	FALSE
21	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ARHGEF12	0.14	-0.01	blup	111	0.02	3.6e-02	-6.3	-6.0	2.7e-09	0.04	0.02	0.50	FALSE
22	The Cancer Genome Atlas	Stomach Adenocarcinoma	TREH	0.16	0.14	enet	1	0.14	1.8e-10	-11.9	11.9	1.7e-32	-0.95	0.00	1.00	FALSE
23	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DDX6	0.26	0.09	lasso	3	0.08	9.6e-04	-7.3	6.7	2.4e-11	-0.54	0.01	0.43	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	CBL	0.03	0.03	enet	9	0.02	1.1e-02	-4.8	5.2	2.2e-07	-0.01	0.01	0.92	FALSE
25	The Cancer Genome Atlas	Thyroid Carcinoma	DDX6	0.05	0.03	blup	14	0.03	1.2e-03	-7.7	6.4	1.4e-10	-0.67	0.00	0.96	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	TREH	0.27	0.18	lasso	3	0.21	8.6e-20	3.8	8.1	5.7e-16	-0.65	0.98	0.02	FALSE