Best TWAS P=4.01e-09 · Best GWAS P=7.56e-12 conditioned to 0.00905
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PSTPIP1 | 0.07 | 0.05 | lasso | 3 | 0.03 | 1.0e-03 | -5.2 | -5.1 | 2.8e-07 | 0.00 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Brain Nucleus accumbens basal ganglia | PEAK1 | 0.17 | 0.12 | lasso | 4 | 0.08 | 2.8e-03 | -5.3 | 5.2 | 2.0e-07 | 0.01 | 0.02 | 0.93 | TRUE |
| 3 | GTEx | Brain Putamen basal ganglia | PPCDC | 0.32 | 0.03 | enet | 42 | 0.13 | 4.9e-04 | 3.1 | 5.9 | 4.0e-09 | -0.47 | 0.10 | 0.46 | TRUE |
| 4 | GTEx | Breast Mammary Tissue (Female) | AC105020.1 | 0.23 | 0.00 | lasso | 5 | 0.00 | 4.8e-01 | -2.5 | -5.2 | 2.2e-07 | 0.01 | 0.00 | 0.08 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | ETFA | 0.05 | 0.00 | enet | 13 | 0.00 | 2.8e-01 | 5.3 | 5.5 | 3.9e-08 | 0.00 | 0.02 | 0.94 | TRUE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C15orf39 | 0.03 | 0.01 | blup | 16 | 0.01 | 5.4e-02 | -5.3 | -5.2 | 2.5e-07 | 0.79 | 0.00 | 0.87 | TRUE |
| 7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SCAMP5 | 0.09 | 0.03 | blup | 41 | 0.08 | 3.3e-05 | 3.2 | 5.1 | 2.9e-07 | -0.48 | 0.19 | 0.63 | FALSE |