Hub : Genes

C15orf39

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.0940	0.0400	0.00400	0.047	NA	0.006	NA	0.048	0.00180	NA	0.1400	NA	0.0017
2	GTEx	Breast Mammary Tissue (Male)	0.1407	0.0937	0.06800	-0.012	NA	0.007	NA	0.012	0.82000	NA	0.2200	NA	0.1700
3	GTEx	Breast Mammary Tissue (Female)	0.0892	0.0594	0.07000	0.122	NA	-0.007	NA	0.050	0.00018	NA	0.6100	NA	0.0130
4	TCGA	Colon Adenocarcinoma	0.1370	0.0600	0.00061	0.059	0.034	0.039	NA	0.036	0.00027	0.0047	0.0026	NA	0.0038
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0261	0.0139	0.00190	0.009	0.007	-0.002	NA	-0.001	0.03000	0.0540	0.5600	NA	0.4000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.1	0.1	0.5	-0.7	0.2	-0.4	0.0	0.0
Bipolar Disorder or Schizophrenia	0.2	0.4	1.4	0.7	1.2	0.2	0.0	0.0
Depressed Affect (Nagel 2018)	0.7	1.5	5.4	-1.0	-2.3	-0.3	-0.8	0.8
Depression (Nagel 2018)	3.3	4.9	8.5	-2.7	-2.9	0.9	-2.5	1.3
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.4	0.2	0.0	0.0	0.2	-0.6
Neuroticism (Nagel 2018)	0.1	0.2	0.3	-0.6	-0.6	0.3	0.1	-0.4
Schizophrenia (2018)	0.4	0.9	2.0	1.4	1.4	0.6	0.0	0.0
Schizophrenia vs Biploar Disorder	0.6	0.8	2.6	1.6	0.4	1.2	0.0	0.0
Worry (Nagel 2018)	0.4	0.9	1.5	-1.2	-1.1	0.2	-1.2	-0.7
Alzheimer’s Disease (in mother)	0.7	0.8	1.8	-1.1	-0.6	-0.1	-1.3	-0.7
Alzheimer’s Disease (in father)	1.2	1.3	4.1	-1.1	-0.9	0.1	-0.7	-2.0
Alzheimer’s Disease (including proxy)	1.5	2.2	4.2	-1.7	-1.2	-0.0	-1.5	-2.0
Crohns Disease (2017)	0.7	1.6	4.2	-1.4	-0.4	-2.0	0.5	1.2
Irritable Bowel Disease (IBD)	0.7	1.7	5.4	-1.2	-0.3	-2.3	1.2	0.2
Ulcerative Colitis (UC)	0.3	0.5	1.0	-0.3	-0.0	-1.0	1.0	-0.7
Major Depression (MDD)	0.2	0.3	1.1	-0.5	-1.0	-0.0	0.0	0.0
Reaction Time	0.6	1.1	2.6	-0.1	1.3	-1.0	0.6	-1.6
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.6	0.0	-0.2	0.7	0.1	-0.8
Breast Cancer	0.2	0.5	1.9	-0.8	-0.2	1.4	0.3	0.2
Ovarian Cancer	0.1	0.1	0.3	-0.2	-0.5	0.4	0.4	-0.2
Prostate Cancer	0.6	0.8	1.7	-0.2	-1.2	0.9	0.2	-1.3
Age at First Birth	1.4	2.0	4.5	1.9	2.1	-0.3	0.0	1.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.5	2.6	0.1	-0.1	-0.1	0.0	-1.6
Coronary Artery Disease (CAD)	1.8	2.2	5.9	-1.2	-1.9	-2.4	0.0	0.0
Crohns Disease (2012)	0.8	1.3	4.7	-1.3	-0.1	-2.2	0.0	0.0
Mean Putamen Volume	0.5	0.6	1.4	-1.2	-0.4	-1.1	0.0	0.0
Fasting Glucose	1.6	1.9	4.2	0.5	-1.1	0.6	-2.1	1.9
HbA1C	0.4	0.4	1.9	-0.3	-0.4	-0.4	0.0	-1.4
HDL Cholesterol	0.7	1.1	3.8	-0.9	0.8	0.4	0.0	-1.9
LDL Cholesterol	1.5	2.3	7.3	-0.7	-1.8	-0.7	0.0	-2.7
Lupus	1.8	2.8	6.4	1.3	0.1	2.1	1.3	2.5
Neuroticism (2016)	0.3	0.4	0.6	0.7	-0.5	0.8	0.6	-0.5
Primary Biliary Cirrhosis	0.6	0.8	3.5	-0.8	-1.9	-0.1	0.0	0.0
Rheumatoid Arthritis	0.6	0.8	2.2	-0.9	-1.0	1.5	0.0	0.3
Schizophrenia (2014)	0.2	0.5	1.1	0.5	1.1	1.0	0.0	0.0
Triglycerides	0.3	0.4	1.4	-0.2	-1.2	-0.5	0.0	0.7
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.6	-0.8	0.2	0.2	0.0	0.0
Ulcerative Colitis	0.3	0.4	1.6	-0.5	-0.5	-1.3	0.0	0.0
Blood Eosinophil Count	0.3	2.4	7.1	-0.5	-1.6	1.4	-2.7	0.2
Blood Platelet Count	2.4	27.3	63.2	-6.0	-8.0	-0.3	-5.8	1.7
Blood Red Count	1.9	18.0	68.9	2.9	2.6	1.4	1.9	8.3
Blood White Count	2.3	17.4	43.8	-4.5	-6.6	-0.3	-4.0	2.5
Heel T-Score	1.0	7.8	26.6	0.7	2.6	-0.2	-2.2	-5.2
BMI	1.3	7.5	12.1	-3.1	-2.1	-1.5	-3.5	-3.0
Height	0.7	12.6	21.8	3.0	4.7	1.5	4.2	-3.5
Waist Hip Ratio (WHR)	0.2	0.8	2.6	0.2	-1.6	1.0	-0.3	0.0
Systolic Blood Pressure	0.8	4.1	16.1	-1.3	-0.4	-0.8	-1.4	4.0
Smoking Status	0.4	0.9	2.5	0.0	-0.1	-1.6	0.5	1.3
Allergy or Eczema	2.7	7.2	31.1	1.1	1.3	0.3	1.3	-5.6
Cardiovascular Disease	1.3	4.3	14.5	-1.9	-0.8	-0.4	-1.7	3.8
Hypothyroidism (self reported)	0.4	1.0	5.0	-0.1	0.1	0.1	-0.3	-2.2
Respiratory disease	0.9	1.9	5.4	-0.4	0.8	-1.8	-0.0	-2.3
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.9	-0.7	-0.7	-0.4	-1.0	0.8
Lung FEV1/FVC ratio	0.7	3.4	10.1	-1.4	-1.2	1.9	0.1	3.2
Lung FVC	0.6	2.8	7.1	0.7	1.5	-1.7	2.7	1.2
Neuroticism	0.2	0.4	0.6	-0.7	-0.7	-0.8	-0.5	-0.2
Chronotype (morning person)	0.5	1.2	2.5	-0.9	1.3	-0.9	-0.5	-1.6
Hair Pigment	0.0	0.5	1.4	0.5	0.7	1.2	0.1	0.4
Tanning	0.2	2.2	7.9	0.7	0.8	-1.1	0.8	-2.8
Hand grip strength (left)	0.8	2.1	3.2	0.9	1.8	-1.8	1.7	-0.6
Number of treatments/medications taken	2.2	4.0	13.9	-3.7	-1.2	-1.1	-1.9	-0.1
Average weekly spirits intake	0.9	1.1	2.6	-1.6	-0.5	-0.0	-0.3	-1.6
Sensitivity / hurt feelings	0.3	0.5	0.9	-0.8	-0.7	-0.9	0.6	0.5
Frequency of depressed mood in last 2 weeks	3.8	5.3	12.2	-2.1	-3.5	0.5	-1.7	2.6
Hearing difficulty/problems: Yes	1.1	1.7	7.6	-0.5	-0.4	-0.8	-0.0	-2.8
Relative age of first facial hair	0.2	0.4	1.2	0.6	-0.1	-0.7	-0.2	-1.1
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.7	-1.6	-1.0	-0.0	-0.9	-1.2
Ever used hormone-replacement therapy (HRT)	0.8	1.1	3.1	0.6	-0.8	1.1	-1.8	0.0
Ever had hysterectomy (womb removed)	1.1	1.2	2.3	-1.5	-0.6	-1.1	1.4	0.5
Systolic blood pressure, automated reading	1.3	3.7	6.2	-2.5	-1.5	-0.5	-2.3	2.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.2	-0.1	0.5	0.3	1.1	-0.6
Angina	0.9	1.2	2.5	-1.4	-1.6	0.1	-1.1	-0.2
Medication for hormone replacement therapy	1.1	1.2	3.9	0.3	-1.0	0.6	-2.0	-0.8
Vitamin and mineral supplements	1.2	1.6	6.1	-1.0	-0.1	-2.5	-0.8	0.6
Supplements: Zinc	1.1	1.2	3.8	1.5	0.1	0.2	-1.9	0.5
Medication: Co-codamol	2.9	3.3	6.1	-2.5	-1.5	-1.9	-1.7	-1.5
Medication: Metformin	0.6	0.9	1.6	-1.3	-0.8	-0.5	-1.2	0.4
Diabetes (father)	0.9	1.1	2.1	0.9	1.4	0.2	1.4	-0.7
Diabetes (mother)	0.2	0.3	0.7	0.7	-0.3	0.2	0.6	0.8
Severe depression (siblings)	0.1	0.1	0.4	0.1	0.5	0.2	0.6	-0.1
Pack years adult smoking proportion	0.1	0.1	0.4	0.3	0.4	-0.6	-0.1	-0.1
Impedance of leg (right)	0.4	1.8	4.4	-0.9	-0.7	1.8	0.1	2.1
Leg fat-free mass (left)	0.6	3.4	10.5	-0.0	0.6	-2.5	0.3	-3.2
Trunk fat percentage	1.2	4.9	10.1	-2.3	-2.0	-1.0	-3.2	-2.0
Hand grip strength (right)	1.1	2.9	5.0	1.4	1.7	-0.6	2.2	-2.1
Townsend deprivation index at recruitment	1.2	1.7	3.8	-1.2	-1.9	-1.4	-1.0	0.5
Current tobacco smoking	1.4	2.3	5.6	-1.0	-1.6	-1.4	-0.0	2.4
Average weekly fortified wine intake	1.6	1.9	3.4	1.4	1.8	0.1	1.6	-1.2
Maternal smoking around birth	0.3	0.5	1.9	-0.2	-0.1	-1.4	-0.6	-0.4
Fed-up feelings	0.7	1.4	2.8	-1.0	-1.7	-1.4	-0.7	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	5.6	7.5	16.6	-3.4	-4.1	0.5	-3.0	-0.0
Relative age voice broke	0.5	0.7	1.4	1.0	0.0	1.2	-0.7	0.8
Taking other prescription medications	3.4	5.2	15.9	-4.0	-2.4	-1.3	-1.6	-0.7
Age when periods started (menarche)	0.1	0.3	0.9	-0.9	0.2	-0.1	0.9	0.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	2.2	-1.2	0.1	-1.5	-0.6	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.9	1.3	0.6	0.5	-0.6	-1.7
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.1	0.2	-1.0	0.6	-0.7	1.0
Qualifications: CSEs or equivalent	0.5	0.7	1.6	0.1	0.4	1.2	-0.6	1.3
Serious illness, injury or assault to yourself	1.2	1.4	6.4	-0.1	0.8	-0.1	0.2	-2.5
High blood pressure	1.1	3.1	12.1	-1.5	-0.3	0.4	-0.9	3.5
Hayfever, allergic rhinitis or eczema	1.6	3.4	12.9	0.6	1.5	0.3	1.3	-3.6
Multivitamins +/- minerals	1.0	1.3	4.1	-0.2	-0.7	2.0	0.1	-1.3
Stomach or abdominal pain in last month	0.9	1.1	2.6	-0.5	-1.6	0.8	-0.6	-1.3
Supplements: Glucosamine	1.0	1.3	4.9	-0.4	0.3	-0.9	-0.6	-2.2
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	4.5	-0.0	0.1	-0.9	2.1	-0.2
Medication: Atenolol	1.2	1.5	4.4	-0.5	-1.3	0.4	-1.1	2.1
Medication: Levothyroxine sodium	0.9	1.6	6.9	0.5	-0.3	0.8	-0.4	-2.6
Sitting height	0.3	2.3	8.8	1.0	1.2	-0.1	3.0	0.5
Chronic bronchitis/emphysema (father)	1.6	1.9	5.7	-2.4	-1.4	0.3	-0.1	-1.2
High blood pressure (mother)	1.2	1.7	5.6	0.0	1.0	-1.0	1.0	2.4
Body mass index (BMI)	1.6	7.0	9.8	-2.8	-2.2	-2.4	-3.1	-2.6
Impedance of leg (left)	0.4	2.2	6.6	-0.1	-0.8	2.6	-0.2	1.9
Leg predicted mass (left)	0.7	3.6	11.2	0.0	0.6	-2.5	0.3	-3.3
Trunk fat mass	1.0	4.5	7.1	-2.0	-1.6	-1.5	-2.7	-2.5
Waist circumference	1.1	3.9	11.7	-1.6	-1.0	-1.0	-1.7	-3.4
Number of incorrect matches in round	1.2	1.9	5.4	-0.2	-1.6	-0.5	-2.3	1.2
Past tobacco smoking	0.3	0.5	1.7	-0.3	-0.7	-0.3	-1.3	-0.2
Alcohol usually taken with meals	0.4	0.7	2.2	-0.8	-0.6	0.3	-1.5	-0.5
Nervous feelings	0.4	0.7	3.0	-0.2	-0.7	-0.2	0.3	-1.7
Frequency of tenseness / restlessness in last 2 weeks	1.9	2.9	9.6	-1.3	-3.1	-0.4	-1.7	0.6
Hearing difficulty/problems with background noise	3.6	5.7	11.2	2.9	2.8	-0.0	1.2	-3.3
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	0.6	0.7	-0.6	0.8	-0.2
Had menopause	1.4	1.8	3.1	1.7	1.8	0.6	1.1	-1.2
Had other major operations	0.1	0.2	0.3	0.1	-0.5	0.5	-0.4	0.2
Forced vital capacity (FVC)	0.8	3.1	9.9	0.9	2.0	-0.6	3.1	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	3.9	0.8	1.0	-0.1	-0.2	-2.0
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	5.1	-0.3	-2.3	-0.5	-0.5	1.0
Qualifications: None of the above	0.4	0.8	1.6	-1.3	-1.0	-0.6	-0.4	1.1
Financial difficulties in last 2 years	1.7	2.2	5.0	-1.0	-1.2	-0.5	-1.9	-2.2
Mouth/teeth dental problems	1.1	1.7	7.3	0.3	0.8	0.1	0.8	2.7
Heart attack	0.6	0.8	1.6	-0.8	-1.1	1.3	0.5	0.4
Allergy	1.7	3.9	9.2	-0.6	-2.4	0.9	-1.9	3.0
Pain all over the body in last month	0.1	0.1	0.4	-0.7	-0.1	-0.4	-0.2	-0.2
Diabetes (self-reported)	0.2	0.3	1.0	0.2	0.5	-0.3	0.1	1.0
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.7	-0.6	-0.8	1.3	-0.3	-0.9
Medication: Ramipril	0.2	0.3	1.2	-0.1	0.1	1.1	0.4	0.5
Medication: Simvastatin	0.3	0.5	1.3	-0.3	0.1	1.1	-0.2	1.0
Fluid intelligence score	0.5	1.0	1.9	1.2	1.0	0.7	1.4	-0.7
Illnesses of siblings	1.7	2.4	5.4	2.3	1.7	-0.2	1.4	-1.2
Neuroticism score	1.0	2.1	4.2	-1.6	-1.9	-2.0	-0.5	-0.2
Weight	0.8	4.0	12.9	-1.2	-0.5	-1.9	-1.4	-3.6
Impedance of arm (right)	0.8	3.8	9.2	1.4	1.1	3.0	1.1	2.3
Arm fat percentage (right)	1.3	5.1	10.4	-2.4	-2.4	-1.1	-3.2	-1.6
Trunk fat-free mass	0.6	3.2	8.4	0.4	1.0	-2.2	1.3	-2.9
Hip circumference	1.0	4.4	15.2	-0.8	0.4	-1.5	-1.9	-3.9
Time employed in main current job	0.2	0.3	0.6	-0.2	0.1	-0.6	-0.5	-0.8
Alcohol intake versus 10 years previously	0.2	0.3	0.9	-0.1	0.6	-0.2	0.3	1.0
Father’s age at death	3.2	4.2	8.3	1.8	2.3	2.0	0.3	-2.9
Worrier / anxious feelings	0.5	1.0	2.1	-1.0	-1.5	-1.0	-0.6	0.6
Frequency of tiredness / lethargy in last 2 weeks	3.0	4.9	9.0	-2.5	-3.0	-0.9	-2.5	-1.7
Falls in the last year	1.1	1.5	4.6	0.4	0.9	-0.7	1.3	-2.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	-0.5	-0.7	0.2	-0.5	0.9
Number of live births	0.4	0.5	1.7	0.1	-0.4	0.2	1.3	0.7
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	4.1	0.1	0.8	-0.4	2.0	-0.0
Pulse rate	0.1	0.1	0.3	0.2	0.1	0.1	0.6	0.5
Happiness	0.2	0.2	0.6	0.0	-0.6	-0.8	-0.0	-0.5
Noisy workplace	0.9	1.0	3.1	-1.2	0.6	-1.8	-0.6	-0.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.7	-0.2	-0.7	-0.7	-0.9	-1.6
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.1	5.5	2.4	0.7	1.8	-1.2	-0.1
Mouth/teeth dental problems: Dentures	0.6	0.9	2.9	-0.9	0.4	-1.0	-0.3	-1.7
Asthma	0.7	1.3	3.0	-0.7	1.7	-1.4	0.7	-0.8
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	5.2	-1.8	-0.2	-0.2	-1.3	-2.3
Medication: Cholesterol lowering	0.8	1.2	1.9	-1.4	0.8	1.4	0.4	1.3
Depression (self-reported)	0.8	1.0	2.7	-0.4	-1.2	-0.5	-1.7	-0.6
Medication: Lansoprazole	1.4	1.6	3.1	-1.5	-1.8	-0.9	-1.2	-0.1
Prospective memory result	1.5	1.8	3.7	1.9	1.2	1.1	1.2	1.2
Lung cancer (father)	1.6	1.9	5.2	0.4	-0.1	1.5	2.3	1.3
Illnesses of mother	0.5	0.7	2.4	0.7	0.2	0.1	-0.7	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	5.4	0.4	0.8	-0.6	2.3	0.8
Pulse wave Arterial Stiffness index	0.9	1.1	4.7	-0.3	0.5	-2.2	-0.1	0.5
Impedance of arm (left)	0.6	2.9	8.6	1.1	1.0	2.9	0.5	1.9
Arm fat mass (right)	1.1	4.5	7.6	-1.9	-1.6	-1.5	-2.6	-2.8
Trunk predicted mass	0.6	3.2	8.6	0.4	0.9	-2.2	1.3	-2.9
Standing height	1.0	9.8	14.4	3.5	3.7	1.2	3.8	-2.8
Length of working week for main job	0.7	0.8	3.0	-0.0	-1.7	0.6	-0.5	-0.5
Exposure to tobacco smoke at home	1.2	1.4	3.3	-1.0	-0.6	1.4	-1.8	0.4
Breastfed as a baby	3.7	4.6	11.0	1.8	3.3	-1.2	2.8	-0.3
Tense / ‘highly strung’	0.7	1.1	4.2	-0.7	-2.0	-0.2	-0.7	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	4.2	-0.4	-2.0	-0.8	-0.6	-0.7
Hair/balding pattern: Pattern 4	0.5	1.3	2.3	-1.5	0.2	-1.5	1.4	0.1
Birth weight of first child	2.8	5.1	9.3	-1.8	-3.0	-1.7	-0.8	-3.0
Peak expiratory flow (PEF)	0.3	0.6	2.3	-0.7	0.3	0.1	0.5	1.5
Pulse wave reflection index	1.3	1.6	5.4	0.0	1.1	-2.3	1.2	-0.3
Ever highly irritable/argumentative for 2 days	1.3	1.6	3.9	-0.7	-2.0	-0.3	-1.8	0.4
Loud music exposure frequency	0.9	1.0	2.5	-0.3	0.1	-1.2	1.1	-1.6
Qualifications: O levels/GCSEs or equivalent	1.5	2.5	7.5	0.0	0.7	0.8	-1.9	-2.7
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	3.0	-0.5	-1.7	-0.8	-0.6	-1.1
Blood clot in the leg (DVT)	0.7	0.9	1.9	-1.4	-0.9	-1.0	0.1	0.8
Medication: Paracetamol	2.6	4.3	12.2	-2.5	-0.6	-3.5	-0.8	-1.4
Headache pain in last month	0.7	1.1	2.9	-1.1	-1.0	-0.4	-0.8	1.7
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	2.6	1.2	-0.9	-1.5	-0.0	-1.6
Glaucoma (self-reported)	0.1	0.1	0.3	-0.1	-0.3	-0.6	0.1	-0.2
Gout (self-reported)	1.1	1.5	4.3	-0.2	1.2	-1.2	2.1	-0.4
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	8.1	0.2	0.4	0.4	-0.0	-2.8
Medication: Amlodipine	0.5	0.7	2.9	0.2	-0.2	0.6	0.2	1.7
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.1	-0.4	1.0	-0.8	1.1	-0.5
Birth weight	0.2	0.5	1.6	-0.7	-0.6	-1.3	-0.0	0.3
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.2	0.3	0.1	-1.1	0.8	0.1
High blood pressure (siblings)	0.7	0.9	3.7	-1.9	-0.5	0.2	-0.7	0.5
Forced vital capacity (FVC), Best measure	0.9	3.3	11.7	1.0	1.8	-0.8	3.4	-0.1
Body fat percentage	1.7	6.6	12.6	-2.9	-2.6	-1.3	-3.5	-1.9
Leg fat percentage (right)	2.7	9.8	16.4	-4.0	-3.6	-1.8	-3.9	-1.2
Arm fat-free mass (right)	0.7	3.4	10.8	-0.0	0.3	-2.4	0.7	-3.3
Exposure to tobacco smoke outside home	1.3	1.8	4.5	-1.6	-1.1	-0.6	-2.1	-0.1
Comparative body size at age 10	0.6	1.5	5.2	-1.2	0.5	-0.4	-0.9	-2.3
Number of full brothers	0.5	0.6	1.8	-0.5	-0.6	-1.3	0.2	-0.7
Worry too long after embarrassment	0.4	0.6	1.4	1.0	1.2	0.1	0.7	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.2	1.0	-0.7	1.1	-0.7	-0.9
Wheeze or whistling in the chest in last year	0.8	1.4	3.9	-0.9	-0.9	-0.8	-0.9	-2.0
Number of children fathered	0.4	0.4	1.5	-0.7	-0.4	-1.2	0.0	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.1	0.0	-1.0	0.6	-0.1	0.5
Age at first live birth	0.8	1.3	2.9	1.6	1.0	-0.4	1.7	-0.2
Pulse wave peak to peak time	1.0	1.2	5.3	0.5	-0.2	2.3	0.4	-0.6
Health satisfaction	0.5	0.7	2.7	-0.2	-0.2	-0.2	0.7	-1.6
Shortness of breath walking on level ground	0.6	0.7	2.0	0.6	0.8	-0.6	-0.4	-1.4
Qualifications: College or University degree	1.2	3.8	7.3	2.7	2.6	-0.5	2.1	-0.5
Eye problems/disorders: None of the above	1.2	1.4	4.8	2.2	1.1	0.5	0.0	0.9
Mouth/teeth dental problems: Loose teeth	2.8	3.4	12.7	-1.3	0.1	-1.5	-0.4	-3.6
Emphysema/chronic bronchitis	1.2	1.4	2.4	1.3	1.5	-0.4	0.7	-1.5
Medication for pain relief, constipation, heartburn	1.6	2.8	7.5	2.7	1.9	1.4	1.1	0.1
Neck or shoulder pain in last month	1.5	2.1	3.3	-1.7	-1.8	-1.4	0.3	-1.5
Medication: Blood pressure	0.9	1.6	2.7	-1.4	0.3	1.5	-0.9	1.6
Angina (self-reported)	1.0	1.3	3.2	-1.5	-1.8	0.3	-0.9	-0.0
Migraine (self-reported)	1.4	1.8	4.2	-0.2	1.0	-1.1	1.5	2.1
Medication: Ibuprofen	1.6	2.0	6.0	-1.5	-0.1	-0.4	-1.2	-2.4
Medication: Allopurinol	1.1	1.5	3.1	-0.0	1.2	-1.6	1.8	-0.6
Medication: Omeprazole	0.4	0.5	1.0	-0.2	-0.9	0.6	-1.0	-0.4
Medication: Seretide 50 evohaler	1.1	1.2	3.4	-1.5	-0.6	0.2	-0.1	-1.9
Mean time to correctly identify matches	0.6	1.1	2.6	-0.4	1.4	-0.9	0.3	-1.6
Heart disease (mother)	0.4	0.5	1.1	-1.1	-0.7	-0.2	-0.9	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	3.6	1.7	1.4	1.9	-0.0	-1.7
Whole body fat mass	1.2	4.8	7.4	-2.1	-1.8	-1.6	-2.7	-2.5
Leg fat mass (right)	1.4	5.6	7.7	-2.8	-2.0	-2.1	-2.5	-2.4
Arm predicted mass (right)	0.7	3.3	11.4	-0.0	0.5	-2.2	0.5	-3.4
Pulse rate, automated reading	0.4	1.3	2.4	-0.9	-1.2	-0.4	1.3	1.6
Alcohol intake frequency.	0.9	2.1	9.8	-0.2	-0.7	0.6	0.2	3.1
Comparative height size at age 10	0.5	2.6	4.2	1.4	2.1	-1.4	2.0	-1.0
Number of full sisters	2.2	2.7	4.5	-1.8	-1.8	-2.1	1.2	1.0
Suffer from ‘nerves’	0.4	0.6	1.2	-0.2	-1.1	0.5	-1.1	-0.3
Overall health rating	1.5	3.3	8.7	-3.0	-1.7	-2.1	-0.3	0.5
Chest pain or discomfort	1.0	1.4	2.8	-0.6	-1.6	0.2	-1.2	-1.7
Had major operations	1.5	1.8	5.8	-1.1	-1.2	0.1	-2.4	0.7
Age at last live birth	0.5	0.8	2.7	0.9	-0.1	-0.5	1.6	0.2
Family relationship satisfaction	0.4	0.5	2.3	0.3	-0.4	0.2	0.2	-1.5
Leg pain on walking	0.4	0.5	1.4	-0.1	0.0	-1.0	-0.3	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.5	1.2	0.6	-0.2	0.7	0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.9	0.1	-0.4	-0.3	-0.6	0.9
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	3.6	0.5	-0.2	0.3	1.6	1.9
Medication: Aspirin	0.5	0.7	1.8	-0.5	-1.0	0.5	0.3	1.3
Supplements: Vitamin C	2.5	2.9	8.7	2.9	1.8	1.2	0.8	0.6
Knee pain experienced in last month	1.0	1.6	2.3	-1.1	-1.3	-1.3	-1.0	-1.5
Hypertension (Self-reported)	1.1	2.9	11.7	-1.4	-0.0	0.4	-0.9	3.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.4	-0.5	-0.4	0.5	0.6	-0.5
Illnesses of father: Heart disease	1.7	2.4	6.7	-2.0	-0.6	-1.0	0.3	2.6
Illnesses of siblings: Diabetes	0.6	0.7	2.4	-0.5	-0.3	0.9	0.3	1.5
Smoking status: Previous	0.4	0.6	1.5	0.5	0.8	-0.1	1.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.9	-0.6	-0.7	-1.4	-0.1	-0.7
Whole body fat-free mass	0.6	3.5	10.6	0.5	0.7	-2.4	0.9	-3.3
Leg fat-free mass (right)	0.6	3.3	11.3	0.6	0.7	-2.0	0.3	-3.4
Arm fat percentage (left)	1.6	6.4	12.7	-2.7	-2.6	-1.3	-3.6	-1.8
Average weekly red wine intake	1.5	2.2	9.1	0.9	0.4	0.6	-0.5	-3.0
Handedness (chirality/laterality): Left-handed	2.2	2.7	5.6	-1.7	-1.4	-0.1	-2.4	-1.7
Mood swings	1.5	2.7	5.9	-1.6	-2.4	-1.0	-0.5	2.0
Loneliness, isolation	0.4	0.5	1.1	0.4	-0.9	-0.5	0.5	1.0
Long-standing illness, disability or infirmity	1.8	2.7	7.7	-2.8	-2.1	-0.1	-1.0	-0.8
Ever had bowel cancer screening	0.6	0.7	1.2	1.1	0.7	-0.7	0.6	-0.9
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.1	0.3	-0.7	-0.4	0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.2	0.9	1.5	0.0	1.4	-0.3
Friendships satisfaction	0.4	0.5	2.1	0.5	0.2	-0.2	1.4	-0.5
Qualifications: nursing, teaching	0.3	0.5	1.6	0.8	0.1	-0.3	0.1	-1.3
Commuting to job workplace: Walk	0.4	0.5	0.8	-0.5	-0.7	0.8	-0.3	-0.9
Eye problems/disorders: Cataract	0.9	1.0	2.1	-1.5	-0.3	0.6	-1.3	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.6	1.2	0.1	1.9	-0.4	-0.6
Medication for cholesterol	1.0	1.6	2.6	1.4	1.4	0.8	1.6	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	4.4	-2.1	-1.4	-0.4	-1.7	-0.6
Back pain experienced in last month	1.3	1.9	5.7	-1.6	-0.8	-0.5	-0.6	-2.4
Mineral and other dietary supplements	0.7	1.0	2.7	-1.2	-1.6	-0.2	-0.6	0.7
Breast cancer (self-reported)	0.3	0.4	0.7	0.8	-0.8	0.5	0.0	-0.4
Asthma (self-reported)	0.5	1.0	2.4	-0.8	1.6	-1.0	0.4	-0.9
Osteoporosis (self-reported)	1.3	1.6	3.4	0.5	1.1	1.3	1.1	1.8
Osteoarthritis (self-reported)	3.4	4.5	7.1	-2.7	-2.0	-1.8	-2.4	-1.5
Medication: Aspirin	0.7	0.9	2.3	-0.7	-1.2	0.4	0.0	1.5
Medication: Gliclazide	0.4	0.4	1.2	-0.3	-0.5	-0.4	0.6	1.1
Illnesses of father: None of the above (group 1)	0.6	0.8	3.0	1.7	0.6	-0.2	0.0	0.6
Smoking status: Current	1.1	1.8	4.5	-0.9	-1.4	-1.2	-0.0	2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.5	-0.4	0.5	-0.7	0.7	0.4
Whole body water mass	0.6	3.5	10.9	0.4	0.8	-2.3	0.9	-3.3
Leg predicted mass (right)	0.6	3.1	10.7	0.6	0.6	-2.0	0.3	-3.3
Arm fat mass (left)	1.2	5.0	7.7	-2.0	-1.9	-1.5	-2.8	-2.7
Number of self-reported non-cancer illnesses	0.6	1.0	4.6	-2.1	-0.2	-0.1	-0.6	-0.3
Average weekly champagne plus white wine intake	0.4	0.6	1.6	-0.0	-1.3	0.2	-0.9	-0.6
Miserableness	1.6	2.8	6.5	-1.9	-2.5	-1.8	-0.8	-0.5
Guilty feelings	0.5	0.8	1.3	-0.1	0.9	-1.1	0.9	-1.1
Wears glasses or contact lenses	1.7	2.0	5.2	1.2	2.3	0.7	0.6	-1.6
Ever taken oral contraceptive pill	0.4	0.5	1.5	0.2	0.8	0.0	1.2	0.3
Hearing aid user	0.5	0.6	1.6	-0.2	-0.6	0.5	0.8	-1.3
Mother’s age at death	1.6	2.0	3.5	1.9	1.5	1.6	1.1	-0.4
Financial situation satisfaction	1.0	1.2	4.7	0.7	-0.6	-0.7	0.0	-2.2
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.2	0.3	1.5	0.9	0.3	-1.2
Commuting to job workplace: Public transport	0.7	0.8	3.1	0.7	1.8	0.2	0.4	-0.7
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	-0.5	-0.3	-0.8	0.3	-0.2
Medication: Blood pressure	0.5	0.9	3.5	-0.7	-0.1	-0.4	-0.4	1.9
Pain type(s) experienced in last month: Hip pain	1.2	1.5	6.2	-0.1	0.7	-0.5	0.7	-2.5
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.0	1.0	0.6	-0.0	0.4	-0.8
High cholesterol (Self-reported)	0.2	0.3	0.8	-0.3	0.1	0.9	-0.8	0.3
Medication: Bendroflumethiazide	0.3	0.4	0.7	-0.8	0.7	0.3	-0.8	0.6
Medication: Paracetamol	1.7	2.6	6.4	-2.1	-0.7	-2.5	-1.1	-0.8
Medication: Lisinopril	0.7	0.9	3.6	-0.4	-0.3	0.7	-0.3	1.9
Medication: Atorvastatin	0.3	0.4	1.4	-1.2	-0.1	-0.6	0.5	0.3
Illnesses of father: High blood pressure	2.0	2.4	7.0	1.7	2.6	0.2	1.5	0.2
Alcohol drinker status: Never	0.9	1.1	4.3	0.9	-0.3	2.1	0.2	0.4
Ever smoked	0.8	1.4	2.4	1.4	1.0	1.5	1.1	0.5
Basal metabolic rate	0.6	3.3	11.1	-0.0	0.3	-2.3	0.1	-3.3
Leg fat percentage (left)	2.5	8.9	15.9	-3.4	-3.5	-1.4	-4.0	-1.6
Arm fat-free mass (left)	0.6	3.1	10.4	0.4	0.6	-2.0	0.6	-3.2
Number of operations (self-reported)	1.4	2.0	4.0	-1.6	-2.0	-0.2	-1.8	-0.3
Average weekly beer plus cider intake	1.7	2.4	4.4	1.1	1.3	0.8	2.0	2.1
Irritability	0.4	0.6	0.9	-0.4	-1.0	-0.8	-0.9	-0.8
Risk taking	0.1	0.2	0.5	0.4	-0.7	-0.1	0.2	0.4
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.3	0.4	1.5	0.7	0.2	-0.4
Fractured/broken bones in last 5 years	0.7	0.9	2.1	1.2	1.0	-1.5	0.3	-0.4
Age started oral contraceptive pill	0.7	0.9	2.6	1.6	1.0	-0.8	0.4	0.1
Diastolic blood pressure, automated reading	1.8	5.5	21.3	-1.9	-1.2	-0.6	-0.6	4.6
Ever depressed for a whole week	0.7	0.8	2.0	1.4	-0.3	0.8	0.6	1.1
Unable to work because of sickness or disability	1.3	1.7	4.5	-2.1	-1.4	-0.8	-1.0	-0.7
Commuting to job workplace: Cycle	0.5	0.6	2.2	0.8	-0.1	0.3	0.2	-1.5
Myopia	0.9	1.4	2.5	1.2	1.1	0.9	1.6	1.0
Vascular/heart problems diagnosed by doctor	1.3	3.4	12.7	1.8	0.8	-0.4	0.6	-3.6
Cholesterol lowering medication	0.4	0.5	1.4	-0.5	-0.1	-1.2	-0.9	-0.2
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.4	-0.2	-1.6	0.8	-1.6	-0.7
Pain experienced in last month	1.7	2.8	5.2	2.2	1.4	1.4	0.3	2.3
Supplements: Calcium	0.9	1.0	2.1	1.5	0.9	0.7	0.4	1.2
Basal cell carcinoma (self-reported)	1.7	2.1	6.8	1.3	1.0	0.5	0.9	-2.6
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.5	-0.8	-1.0	1.2	0.4	0.4
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	1.8	-1.4	-1.2	-1.4	0.4	0.5
Heart disease (siblings)	1.2	1.5	3.5	-1.3	-1.4	-0.4	-0.4	1.9
Alcohol drinker status: Previous	0.2	0.2	0.9	0.2	-1.0	-0.2	0.2	0.1
Pack years of smoking	0.2	0.2	0.5	0.4	0.6	-0.3	-0.1	-0.7
Impedance of whole body	0.6	3.0	8.9	0.8	0.4	3.0	0.5	2.2
Leg fat mass (left)	1.3	5.0	6.8	-2.3	-1.9	-1.8	-2.5	-2.6
Arm predicted mass (left)	0.7	3.4	12.0	0.0	0.6	-2.1	0.5	-3.5