[Hub]/) : Traits : Heel T-Score : ← →

chr1:217,760,821-221,753,645

Best TWAS P=2.55e-38 · Best GWAS P=4.97e-43 conditioned to 1.3e-10

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LYPLAL1	0.04	0.05	lasso	3	0.03	3.6e-04	7.3	-7.8	6.0e-15	0.02	0.62	0.01	TRUE
2	CommonMind	Brain Pre-frontal Cortex	RAB3GAP2	0.04	0.00	blup	450	0.02	2.1e-03	3.1	-6.6	5.4e-11	-0.03	0.10	0.05	TRUE
3	CommonMind	Brain Pre-frontal Cortex	SLC30A10	0.12	0.13	enet	14	0.11	1.8e-13	12.3	-12.9	2.6e-38	0.01	0.22	0.78	TRUE
4	GTEx	Adipose Subcutaneous	RRP15	0.24	0.14	lasso	2	0.12	3.2e-10	5.3	5.3	9.3e-08	0.08	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	RRP15	0.32	0.18	lasso	8	0.22	1.2e-11	5.6	5.2	1.9e-07	0.07	1.00	0.00	FALSE
6	GTEx	Artery Tibial	RRP15	0.19	0.16	lasso	4	0.14	8.7e-11	5.3	5.4	7.3e-08	0.08	1.00	0.00	FALSE
7	GTEx	Artery Tibial	HLA-AS1	0.12	0.03	enet	13	0.05	3.9e-05	3.3	-7.5	6.7e-14	0.21	0.60	0.03	TRUE
8	GTEx	Cells Transformed fibroblasts	RRP15	0.38	0.28	lasso	6	0.28	1.9e-21	5.3	5.5	4.3e-08	0.08	1.00	0.00	FALSE
9	GTEx	Cells Transformed fibroblasts	HLX	0.06	0.00	enet	9	0.00	5.3e-01	-5.1	-5.9	3.7e-09	0.22	0.08	0.03	FALSE
10	GTEx	Esophagus Mucosa	HLX	0.17	0.09	lasso	8	0.09	9.1e-07	6.2	5.6	1.8e-08	-0.07	0.99	0.00	FALSE
11	GTEx	Nerve Tibial	EPRS	0.10	0.02	lasso	3	0.00	3.4e-01	-7.8	7.2	4.2e-13	-0.02	0.22	0.04	TRUE
12	GTEx	Pituitary	RRP15	0.38	0.23	lasso	3	0.23	1.9e-06	5.6	5.3	9.3e-08	0.08	0.33	0.08	FALSE
13	METSIM	Adipose	RRP15	0.28	0.24	bslmm	489	0.23	1.7e-34	5.3	5.2	1.7e-07	0.09	1.00	0.00	FALSE
14	YFS	Blood	BPNT1	0.02	0.03	lasso	4	0.02	1.1e-07	4.2	-6.5	6.7e-11	-0.01	1.00	0.00	TRUE
15	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LYPLAL1	0.04	0.00	blup	39	0.01	1.9e-02	1.7	5.3	1.1e-07	-0.11	0.04	0.44	TRUE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	RRP15	0.11	0.11	lasso	5	0.10	2.5e-20	5.3	5.3	1.2e-07	0.08	0.98	0.02	FALSE
17	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RRP15	0.13	0.13	lasso	1	0.10	1.4e-05	5.6	5.6	1.9e-08	0.08	0.70	0.10	FALSE
18	The Cancer Genome Atlas	Esophageal Carcinoma	SLC30A10	0.25	0.06	blup	173	0.06	6.6e-03	-4.2	5.5	4.3e-08	-0.12	0.06	0.24	FALSE
19	The Cancer Genome Atlas	Glioblastoma Multiforme	BPNT1	0.28	0.02	lasso	5	0.03	5.1e-02	-0.3	-5.7	1.2e-08	-0.02	0.01	0.15	FALSE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HLX	0.05	0.02	blup	46	0.04	1.4e-05	5.9	6.5	6.5e-11	-0.10	0.01	0.97	TRUE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IARS2	0.04	0.00	blup	41	0.01	3.6e-02	-3.6	6.4	2.0e-10	0.00	0.01	0.19	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	RRP15	0.10	0.10	lasso	1	0.10	4.7e-11	5.3	5.3	1.2e-07	0.08	0.95	0.05	FALSE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	RRP15	0.09	0.09	lasso	3	0.09	3.2e-10	5.3	5.2	2.1e-07	0.08	0.97	0.03	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RRP15	0.10	0.09	lasso	3	0.08	9.8e-10	5.6	5.6	2.1e-08	0.08	0.94	0.06	FALSE
25	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	EPRS	0.12	0.02	enet	9	0.04	1.5e-03	-7.8	6.2	6.1e-10	-0.07	0.09	0.06	FALSE
26	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RRP15	0.15	0.12	lasso	2	0.12	1.9e-05	5.3	5.3	9.3e-08	0.08	0.17	0.14	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	RRP15	0.29	0.29	lasso	2	0.29	2.7e-30	5.3	5.4	7.1e-08	0.08	0.96	0.04	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC30A10	0.06	0.03	enet	10	0.04	1.7e-05	-2.7	-8.0	1.6e-15	-0.03	0.08	0.91	TRUE
29	The Cancer Genome Atlas	Stomach Adenocarcinoma	RRP15	0.11	0.09	lasso	3	0.07	8.2e-06	5.6	5.7	1.3e-08	0.07	0.77	0.09	TRUE
30	The Cancer Genome Atlas	Thyroid Carcinoma	EPRS	0.07	0.00	blup	78	0.02	3.1e-03	9.6	5.2	1.9e-07	0.00	0.03	0.03	TRUE
31	The Cancer Genome Atlas	Thyroid Carcinoma	RRP15	0.22	0.25	lasso	3	0.24	1.7e-23	5.3	5.4	8.5e-08	0.08	0.96	0.04	FALSE