Hub : Genes

RAB3GAP2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0400 0.0180 0.0038 0.000 0.019 -0.001 0.017 -0.001 0.37000 0.0021 0.41000 0.0029 0.55000
2 GTEx Artery Tibial 0.0880 0.0424 0.0054 0.012 NA -0.001 NA 0.000 0.03900 NA 0.44000 NA 0.31000
3 TCGA Head and Neck Squamous Cell Carcinoma 0.0284 0.0161 0.0019 0.031 0.016 0.028 NA 0.032 0.00018 0.0059 0.00039 NA 0.00014
4 TCGA Lung Squamous Cell Carcinoma 0.0362 0.0194 0.0061 0.031 0.004 0.017 NA 0.019 0.00018 0.1100 0.00380 NA 0.00300

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 2.5 3.9 7.0 0.5 -2.1 -2.6 -2.0
Bipolar Disorder or Schizophrenia 0.7 1.6 2.8 1.0 -1.3 -1.7 -1.0
Depressed Affect (Nagel 2018) 1.3 2.7 9.5 -0.6 0.5 0.7 3.1
Depression (Nagel 2018) 1.5 2.3 4.2 -1.1 -1.6 -2.0 1.0
Intelligence (Savage-Jansen 2018) 0.9 2.9 3.4 -1.6 -1.6 -1.8 -1.9
Neuroticism (Nagel 2018) 0.6 1.4 3.2 -0.3 -1.3 -0.8 1.8
Schizophrenia (2018) 0.1 0.2 0.7 0.8 0.0 -0.0 0.3
Schizophrenia vs Biploar Disorder 0.8 1.1 2.7 0.3 0.9 1.6 0.9
Worry (Nagel 2018) 0.5 1.1 2.2 -0.8 -1.5 -1.1 0.6
Alzheimer’s Disease (in mother) 1.0 1.2 2.2 -0.9 1.0 1.5 0.7
Alzheimer’s Disease (in father) 0.4 0.4 1.4 0.4 -0.0 -1.2 0.4
Alzheimer’s Disease (including proxy) 0.2 0.3 0.8 -0.0 0.9 0.6 -0.1
Crohns Disease (2017) 1.0 2.1 8.0 -2.8 -0.5 -0.4 0.1
Irritable Bowel Disease (IBD) 2.1 5.0 17.1 -4.1 -1.6 -0.4 -0.2
Ulcerative Colitis (UC) 1.7 3.3 9.4 -3.1 -1.8 -0.4 -0.5
Major Depression (MDD) 0.4 0.5 1.2 -0.2 -0.9 -1.1 -0.2
Reaction Time 0.1 0.2 0.5 -0.1 0.7 -0.2 0.5
Verbal and Numeric Reasoning (VNR) 0.5 1.3 2.3 -0.6 -1.2 -1.5 -1.1
Breast Cancer 0.9 2.2 5.4 2.3 -0.5 -0.5 -1.6
Ovarian Cancer 0.2 0.2 0.5 0.2 0.5 -0.1 0.7
Prostate Cancer 0.1 0.1 0.4 -0.2 0.2 0.7 -0.1
Age at First Birth 5.8 8.5 11.8 -2.0 -3.1 -3.4 -2.9
Bipolar Disorder (2011) 1.3 1.2 1.9 0.9 -0.7 -1.3 -1.4
Body Mass Index (BMI) (2010) 0.4 0.6 2.2 -1.5 -0.0 -0.3 0.2
Coronary Artery Disease (CAD) 0.4 0.5 1.4 0.4 -0.2 -0.5 -1.2
Crohns Disease (2012) 0.2 0.4 0.9 -0.6 0.3 0.3 0.9
Mean Putamen Volume 0.9 1.0 3.1 0.3 0.9 -0.1 -1.8
Fasting Glucose 1.8 2.2 4.6 -0.4 -2.2 -0.6 -1.9
HbA1C 0.5 0.6 1.1 -0.4 -1.0 0.5 -0.9
HDL Cholesterol 0.7 1.1 3.1 -1.8 -0.9 0.4 -0.7
LDL Cholesterol 1.0 1.5 3.7 1.0 1.2 1.9 -0.0
Lupus 0.7 1.0 1.5 -1.1 -1.1 -1.2 -0.0
Neuroticism (2016) 1.4 2.0 4.6 0.2 -1.2 -1.4 2.1
Primary Biliary Cirrhosis 1.0 1.4 3.4 0.5 -1.4 -1.9 0.0
Rheumatoid Arthritis 0.7 0.9 2.0 1.1 0.6 0.4 1.4
Schizophrenia (2014) 0.3 0.7 1.5 1.2 0.0 -0.0 1.2
Triglycerides 0.5 0.9 2.5 -0.9 -0.3 -1.6 0.4
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.7 0.3 0.8 1.3 -0.0
Ulcerative Colitis 1.2 1.7 6.0 -2.5 -0.9 0.3 -0.1
Blood Eosinophil Count 0.5 4.0 5.9 2.0 2.4 2.4 0.5
Blood Platelet Count 0.1 1.2 4.2 0.1 -2.1 -0.3 -0.6
Blood Red Count 0.0 0.4 1.1 -0.0 1.1 -0.6 0.1
Blood White Count 0.1 0.6 1.3 0.1 0.9 0.6 1.1
Heel T-Score 1.5 12.1 43.0 -6.6 -1.1 0.7 -1.9
BMI 0.2 1.1 3.4 -1.9 0.6 0.6 0.6
Height 0.1 2.0 3.8 -0.7 -0.8 -1.8 -1.9
Waist Hip Ratio (WHR) 0.1 0.6 1.6 0.2 0.2 -1.2 -0.9
Systolic Blood Pressure 0.7 3.4 5.2 1.6 1.9 2.3 1.5
Smoking Status 0.7 1.6 5.1 -2.2 -1.0 -0.4 0.2
Allergy or Eczema 0.8 2.1 3.9 0.1 -1.6 -2.0 -1.4
Cardiovascular Disease 0.1 0.5 1.4 0.3 0.4 1.2 -0.4
Hypothyroidism (self reported) 0.2 0.5 1.7 0.3 -0.4 -1.3 0.4
Respiratory disease 0.4 0.9 1.5 -0.8 -1.2 -0.2 -1.2
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.8 -0.9 0.6 0.3 0.6
Lung FEV1/FVC ratio 2.5 12.6 23.1 -4.8 -2.9 -3.3 -2.9
Lung FVC 0.4 1.9 3.9 -1.2 0.1 1.4 2.0
Neuroticism 1.3 3.1 5.9 -1.3 -2.4 -1.9 1.1
Chronotype (morning person) 0.1 0.2 0.5 0.2 0.2 -0.7 0.3
Hair Pigment 0.0 0.3 0.5 0.4 -0.6 -0.3 -0.7
Tanning 0.1 0.9 2.4 0.3 0.8 1.6 0.8
Hand grip strength (left) 0.9 2.4 3.5 -1.5 -1.4 -1.5 -1.9
Number of treatments/medications taken 1.0 1.9 6.4 -2.5 -1.0 0.1 -0.3
Average weekly spirits intake 1.0 1.2 4.4 -0.6 -0.2 0.3 2.1
Sensitivity / hurt feelings 1.4 2.4 3.4 -0.5 -1.7 -1.7 1.8
Frequency of depressed mood in last 2 weeks 1.2 1.7 2.7 -0.8 -1.2 -1.4 1.6
Hearing difficulty/problems: Yes 2.1 3.2 6.5 -2.5 -1.6 -1.3 -1.5
Relative age of first facial hair 0.8 1.7 3.9 -0.1 -0.6 1.6 2.0
Other serious medical condition/disability diagnosed by doctor 3.9 5.1 7.5 -1.4 -2.6 -2.7 -2.0
Ever used hormone-replacement therapy (HRT) 0.7 0.8 2.9 0.4 0.4 0.3 1.7
Ever had hysterectomy (womb removed) 3.2 3.6 7.1 0.0 2.7 2.4 1.3
Systolic blood pressure, automated reading 0.8 2.2 3.6 -0.9 1.0 1.9 1.9
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 1.6 0.6 1.3 1.1 1.1
Angina 0.3 0.4 1.0 -0.6 0.0 -0.2 1.0
Medication for hormone replacement therapy 0.5 0.5 1.3 0.1 0.6 0.7 1.1
Vitamin and mineral supplements 1.3 1.7 3.3 1.1 1.4 1.8 -0.7
Supplements: Zinc 2.2 2.4 4.2 -2.0 -1.6 -1.2 1.1
Medication: Co-codamol 0.7 0.8 2.1 -0.7 0.5 1.5 0.4
Medication: Metformin 0.5 0.7 1.8 -1.3 0.3 -0.7 0.6
Diabetes (father) 0.3 0.4 1.1 -1.0 0.5 -0.5 0.0
Diabetes (mother) 0.3 0.4 0.7 0.5 0.3 0.6 -0.8
Severe depression (siblings) 0.4 0.4 1.1 0.6 0.4 1.0 -0.3
Pack years adult smoking proportion 1.2 1.8 3.1 1.8 1.4 0.5 1.4
Impedance of leg (right) 0.7 3.5 12.5 3.5 -0.1 0.2 -1.3
Leg fat-free mass (left) 0.3 1.8 6.2 -2.5 1.0 0.0 -0.5
Trunk fat percentage 0.1 0.2 0.3 -0.6 0.6 0.3 0.4
Hand grip strength (right) 0.5 1.4 1.9 -0.8 -1.1 -1.4 -1.4
Townsend deprivation index at recruitment 1.8 2.6 7.3 0.4 1.6 0.7 2.7
Current tobacco smoking 0.9 1.4 4.9 -0.6 0.5 -0.4 2.2
Average weekly fortified wine intake 2.5 2.9 4.7 -0.9 -1.9 -2.2 -1.6
Maternal smoking around birth 1.9 2.7 5.3 -0.2 1.5 1.8 2.3
Fed-up feelings 3.0 5.5 20.6 0.1 0.6 0.9 4.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 2.0 -1.4 -0.9 -1.2 0.9
Relative age voice broke 1.7 2.5 5.4 0.2 0.7 2.1 2.3
Taking other prescription medications 1.5 2.3 5.3 -2.3 -1.5 -0.4 -1.1
Age when periods started (menarche) 0.7 1.6 2.2 0.2 -1.4 -1.5 -1.4
Bilateral oophorectomy (both ovaries removed) 2.9 3.4 5.5 1.7 2.0 2.3 1.1
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.4 11.9 -3.5 -0.8 0.0 -1.1
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.5 0.5 -0.2 -0.4 0.7
Qualifications: CSEs or equivalent 2.0 2.6 4.4 -0.9 2.1 1.8 1.4
Serious illness, injury or assault to yourself 0.3 0.4 0.8 0.2 -0.7 -0.9 -0.6
High blood pressure 0.3 0.8 1.9 -1.4 0.3 0.9 0.4
Hayfever, allergic rhinitis or eczema 1.8 3.8 7.3 -0.5 -2.1 -1.8 -2.7
Multivitamins +/- minerals 0.8 1.0 2.2 -0.6 -1.0 -1.5 -0.6
Stomach or abdominal pain in last month 3.8 4.7 11.9 -3.5 -2.0 -1.3 -1.2
Supplements: Glucosamine 0.4 0.5 1.4 1.2 -0.2 -0.1 0.9
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.9 -0.5 0.4 0.3 0.9
Medication: Atenolol 0.4 0.5 1.3 -1.1 -0.2 0.4 0.7
Medication: Levothyroxine sodium 0.1 0.2 0.7 0.8 0.4 -0.2 -0.1
Sitting height 0.2 1.2 3.0 -0.7 0.5 -1.0 -1.7
Chronic bronchitis/emphysema (father) 2.0 2.4 3.6 1.9 1.8 1.6 0.2
High blood pressure (mother) 1.3 1.9 6.4 -2.5 -0.9 -0.2 -0.3
Body mass index (BMI) 0.5 2.1 3.3 -1.8 1.2 1.0 1.6
Impedance of leg (left) 0.7 3.6 13.7 3.7 -0.2 0.1 -0.8
Leg predicted mass (left) 0.3 1.8 6.2 -2.5 0.9 0.1 -0.5
Trunk fat mass 0.1 0.5 1.4 -1.2 0.7 0.2 0.5
Waist circumference 0.3 0.9 2.1 -1.4 0.7 -0.1 1.1
Number of incorrect matches in round 2.4 4.0 6.5 1.7 2.6 2.5 0.4
Past tobacco smoking 0.4 0.8 2.6 1.6 0.3 -0.2 0.7
Alcohol usually taken with meals 0.6 1.0 2.0 0.2 -0.9 -1.1 -1.4
Nervous feelings 0.4 0.7 1.2 0.8 0.8 0.6 1.1
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 0.9 0.5 -0.9 -0.9 1.0
Hearing difficulty/problems with background noise 0.6 1.0 2.6 -1.0 -0.5 -0.6 -1.6
Hair/balding pattern: Pattern 2 1.3 1.6 3.1 -1.8 -1.2 -1.4 -0.4
Had menopause 2.1 2.6 7.3 -1.0 0.9 1.1 2.7
Had other major operations 0.5 0.6 1.7 -1.3 -0.5 -0.0 0.6
Forced vital capacity (FVC) 0.1 0.4 0.9 0.8 0.1 0.4 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.7 8.0 -2.8 -1.0 -0.5 -1.3
Ever unenthusiastic/disinterested for a whole week 1.6 2.0 3.5 -1.6 -1.9 -1.3 -0.0
Qualifications: None of the above 4.2 9.0 13.4 1.9 3.7 2.9 3.2
Financial difficulties in last 2 years 0.9 1.2 3.1 1.0 0.8 0.2 -1.8
Mouth/teeth dental problems 0.2 0.3 0.7 0.8 -0.6 0.2 -0.5
Heart attack 0.8 1.0 1.4 -0.8 -1.0 -1.2 -1.0
Allergy 2.7 6.2 9.9 1.8 3.1 2.2 2.7
Pain all over the body in last month 0.8 0.9 1.9 -0.6 -0.7 -0.9 -1.4
Diabetes (self-reported) 0.6 0.9 3.4 -1.8 -0.2 -0.3 0.4
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 2.9 0.3 -1.1 -1.1 -1.7
Medication: Ramipril 0.2 0.3 0.4 -0.6 -0.4 0.7 -0.4
Medication: Simvastatin 0.3 0.4 0.7 -0.8 -0.8 -0.2 -0.5
Fluid intelligence score 0.6 1.3 2.0 -0.9 -0.8 -1.4 -1.4
Illnesses of siblings 0.3 0.5 1.5 1.2 0.1 -0.2 -0.6
Neuroticism score 1.1 2.4 3.8 -1.2 -1.7 -1.1 1.9
Weight 0.2 1.1 2.7 -1.7 1.1 0.4 0.6
Impedance of arm (right) 0.6 2.6 6.3 2.5 -1.1 -0.9 -1.5
Arm fat percentage (right) 0.2 0.8 0.9 -0.9 0.9 0.8 0.9
Trunk fat-free mass 0.3 1.5 4.5 -2.1 1.2 0.4 -0.1
Hip circumference 0.2 0.8 2.6 -0.0 0.7 0.3 1.6
Time employed in main current job 0.6 0.7 1.7 -0.5 0.4 1.3 -0.8
Alcohol intake versus 10 years previously 0.3 0.5 1.1 -0.1 0.1 0.8 1.1
Father’s age at death 1.2 1.6 4.5 -0.4 -1.3 0.3 -2.1
Worrier / anxious feelings 2.5 4.7 8.4 -1.4 -2.9 -2.8 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.7 -0.8 0.1 -0.2 0.7
Falls in the last year 1.4 1.9 3.3 1.8 0.9 1.0 1.6
Hair/balding pattern: Pattern 3 0.5 0.7 1.4 -0.8 -0.4 -1.2 -0.7
Number of live births 0.4 0.5 1.2 1.1 -0.0 0.3 -0.9
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 3.4 -0.7 -0.8 -0.3 -1.8
Pulse rate 0.3 0.4 0.7 0.7 -0.3 -0.6 -0.9
Happiness 0.3 0.4 0.7 0.6 -0.8 -0.7 -0.3
Noisy workplace 1.8 2.2 3.5 -1.5 -1.9 -1.3 1.2
Qualifications: A levels/AS levels or equivalent 2.1 4.7 9.9 0.9 -1.5 -2.4 -3.1
Serious illness, injury or assault of a close relative in last 2 years 1.4 1.6 5.1 2.3 -0.8 -0.8 -0.3
Mouth/teeth dental problems: Dentures 1.3 2.2 5.5 -1.2 1.0 0.8 2.3
Asthma 0.5 0.9 1.3 -1.1 -0.6 0.8 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.0 -1.1 -0.6 0.4 -1.4
Medication: Cholesterol lowering 0.5 0.8 1.0 -0.9 -1.0 -1.0 0.5
Depression (self-reported) 3.5 4.2 8.8 -3.0 -2.0 -1.8 1.1
Medication: Lansoprazole 0.5 0.6 1.4 0.6 1.2 0.6 0.4
Prospective memory result 1.0 1.2 3.2 -0.5 -1.0 -0.7 1.8
Lung cancer (father) 2.5 2.9 4.8 0.1 1.9 1.8 2.2
Illnesses of mother 0.3 0.4 0.6 0.8 0.7 -0.6 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 1.0 -0.2 -0.3 -0.3 -1.0
Pulse wave Arterial Stiffness index 0.8 1.0 1.8 -0.9 -0.8 -0.8 -1.3
Impedance of arm (left) 0.6 2.8 5.1 2.2 -1.5 -1.0 -1.7
Arm fat mass (right) 0.3 1.1 1.9 -1.4 1.2 0.7 0.9
Trunk predicted mass 0.3 1.5 4.1 -2.0 1.2 0.4 -0.1
Standing height 0.1 1.0 3.0 0.1 0.0 -1.0 -1.7
Length of working week for main job 0.4 0.4 0.9 0.9 0.6 0.6 -0.4
Exposure to tobacco smoke at home 0.6 0.7 1.2 -1.1 0.7 0.8 0.5
Breastfed as a baby 0.1 0.2 0.3 0.2 -0.4 -0.6 -0.5
Tense / ‘highly strung’ 0.6 1.0 1.4 -0.1 -1.1 -1.2 1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.3 -0.2 -0.5 -0.6 0.5
Hair/balding pattern: Pattern 4 0.5 1.2 2.4 -1.2 -0.5 -0.9 -1.5
Birth weight of first child 0.7 1.3 3.4 1.8 1.1 0.4 -0.7
Peak expiratory flow (PEF) 0.4 1.0 2.5 -0.4 -0.6 1.0 -1.6
Pulse wave reflection index 0.4 0.5 1.2 -0.7 -0.6 -0.4 -1.1
Ever highly irritable/argumentative for 2 days 1.2 1.5 2.6 -1.6 -1.6 -0.2 -0.9
Loud music exposure frequency 1.2 1.3 3.5 -0.1 1.9 0.8 0.9
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 1.8 -1.3 -1.4 -1.0 -1.0
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.4 0.2 1.2 0.8 0.5
Blood clot in the leg (DVT) 0.9 1.1 2.4 -1.1 -1.5 -1.0 0.3
Medication: Paracetamol 0.8 1.3 2.5 -1.6 0.4 1.6 -0.0
Headache pain in last month 0.3 0.5 0.9 0.1 -0.7 -1.0 -0.8
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.4 0.6 -0.2 -0.5 -0.4
Glaucoma (self-reported) 1.8 2.2 3.9 -0.8 -2.0 -2.0 -0.3
Gout (self-reported) 0.6 0.8 2.0 -1.4 -1.1 -0.3 0.1
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.5 -0.6 -0.7 -1.6 -0.1
Medication: Amlodipine 1.2 1.7 3.5 -0.1 0.8 1.6 1.9
Medication: Ventolin 100micrograms inhaler 0.6 0.8 2.0 -0.4 0.1 1.4 1.0
Birth weight 0.0 0.1 0.1 0.3 -0.2 -0.3 0.3
Chronic bronchitis/emphysema (mother) 0.8 1.0 2.5 1.1 -0.2 0.3 1.6
High blood pressure (siblings) 1.2 1.7 5.9 -2.4 -0.7 -0.3 -0.5
Forced vital capacity (FVC), Best measure 0.1 0.2 0.6 0.8 0.2 0.3 -0.3
Body fat percentage 0.1 0.4 0.5 -0.7 0.6 0.4 0.6
Leg fat percentage (right) 0.3 0.9 1.5 -0.6 1.1 0.8 1.2
Arm fat-free mass (right) 0.3 1.7 4.6 -2.1 1.4 0.4 -0.1
Exposure to tobacco smoke outside home 0.3 0.4 1.1 -0.6 0.3 0.4 1.0
Comparative body size at age 10 1.7 4.7 7.0 -2.6 -2.5 -2.0 -1.2
Number of full brothers 0.4 0.5 1.1 1.1 -0.3 0.5 -0.6
Worry too long after embarrassment 1.3 2.2 4.5 0.3 -2.1 -2.1 -0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.4 3.4 -0.3 -1.9 -1.3 -0.3
Wheeze or whistling in the chest in last year 0.4 0.7 2.3 -1.5 -0.2 0.6 0.1
Number of children fathered 0.0 0.1 0.1 0.2 0.3 0.0 0.3
Reason for reducing amount of alcohol drunk: Health precaution 2.0 2.4 4.0 2.0 1.8 1.5 -0.3
Age at first live birth 3.2 5.7 8.7 0.3 -2.9 -2.9 -2.4
Pulse wave peak to peak time 0.7 0.9 1.4 1.0 0.7 0.7 1.2
Health satisfaction 2.9 3.7 6.3 -2.5 -2.0 -1.3 -1.7
Shortness of breath walking on level ground 2.3 2.7 7.8 -2.8 -1.7 -0.3 -0.3
Qualifications: College or University degree 2.7 8.6 18.8 0.0 -2.6 -3.0 -4.3
Eye problems/disorders: None of the above 2.0 2.3 3.2 1.4 1.8 1.2 -1.6
Mouth/teeth dental problems: Loose teeth 0.5 0.6 0.8 -0.9 -0.6 -0.8 -0.9
Emphysema/chronic bronchitis 0.5 0.6 1.8 0.2 -0.7 -1.4 -0.3
Medication for pain relief, constipation, heartburn 1.1 1.9 4.8 2.2 1.4 -0.1 1.0
Neck or shoulder pain in last month 0.1 0.1 0.2 -0.5 -0.4 -0.0 -0.1
Medication: Blood pressure 0.2 0.3 0.6 -0.5 0.3 0.8 -0.2
Angina (self-reported) 0.4 0.6 1.4 -0.8 -0.2 -0.5 1.2
Migraine (self-reported) 0.2 0.3 0.6 -0.8 -0.5 -0.2 -0.5
Medication: Ibuprofen 0.6 0.7 1.1 -1.1 -0.9 -0.1 -0.8
Medication: Allopurinol 0.2 0.3 0.9 -1.0 -0.2 0.4 -0.2
Medication: Omeprazole 1.4 1.7 3.7 -1.6 -0.5 -0.1 -1.9
Medication: Seretide 50 evohaler 0.2 0.2 0.7 -0.4 -0.2 -0.2 -0.9
Mean time to correctly identify matches 0.4 0.8 2.0 -0.6 1.0 0.2 1.4
Heart disease (mother) 0.5 0.7 1.5 -1.2 0.1 0.1 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.4 0.3 -0.4 -0.0 -0.7
Whole body fat mass 0.2 0.8 1.6 -1.3 1.0 0.5 0.6
Leg fat mass (right) 0.3 1.0 1.7 -1.3 1.2 0.7 0.7
Arm predicted mass (right) 0.3 1.7 4.0 -2.0 1.6 0.6 0.0
Pulse rate, automated reading 0.3 0.9 1.8 0.9 -0.4 -0.9 -1.3
Alcohol intake frequency. 0.2 0.5 1.1 -0.3 1.1 0.4 0.9
Comparative height size at age 10 0.4 1.9 2.7 0.9 1.5 1.4 1.6
Number of full sisters 0.3 0.3 0.6 -0.7 -0.4 0.6 -0.5
Suffer from ‘nerves’ 0.3 0.4 0.8 -0.9 0.1 0.5 0.8
Overall health rating 0.3 0.7 2.0 -1.4 -0.1 -0.0 -0.9
Chest pain or discomfort 0.7 1.0 2.8 -1.7 0.4 1.0 0.2
Had major operations 0.6 0.7 1.9 0.1 -0.9 0.3 -1.4
Age at last live birth 4.3 6.3 11.1 0.9 -2.6 -3.3 -2.5
Family relationship satisfaction 0.2 0.2 0.5 -0.7 -0.1 0.3 -0.4
Leg pain on walking 1.1 1.4 3.2 -1.2 -0.8 0.4 -1.8
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.5 0.1 0.2 -0.1 0.7
Commuting to job workplace: Car/motor vehicle 2.0 2.3 3.9 -1.4 -2.0 -1.4 -1.2
Illness, injury, bereavement, stress in last 2 years 2.4 2.9 9.2 -3.0 -0.6 -0.4 -1.4
Medication: Aspirin 0.6 0.8 1.4 -0.8 -1.2 -0.9 -0.6
Supplements: Vitamin C 2.1 2.5 3.9 -2.0 -1.1 -1.4 1.7
Knee pain experienced in last month 0.9 1.4 3.5 -1.9 0.9 1.1 -0.0
Hypertension (Self-reported) 0.3 0.8 1.2 -1.0 0.5 1.1 0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.5 -1.6 0.6 0.6 0.7
Illnesses of father: Heart disease 0.2 0.3 0.4 0.6 -0.5 -0.4 -0.6
Illnesses of siblings: Diabetes 1.0 1.2 4.1 -2.0 -0.9 -0.1 -0.3
Smoking status: Previous 0.7 1.0 2.9 -1.7 0.2 1.0 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 3.5 0.3 -0.3 -0.1 -1.9
Whole body fat-free mass 0.3 1.7 5.1 -2.3 1.3 0.3 -0.2
Leg fat-free mass (right) 0.3 1.9 6.4 -2.5 1.0 -0.1 -0.3
Arm fat percentage (left) 0.2 0.8 1.4 -1.2 0.8 0.7 0.8
Average weekly red wine intake 0.6 0.9 1.7 0.9 -0.4 -1.3 0.9
Handedness (chirality/laterality): Left-handed 3.2 3.9 6.8 -2.0 -2.6 -2.0 -0.8
Mood swings 1.3 2.3 6.5 0.3 1.0 1.3 2.6
Loneliness, isolation 1.4 2.0 6.1 -1.1 -0.7 -0.5 2.5
Long-standing illness, disability or infirmity 2.6 4.0 9.8 -1.7 -1.6 -1.0 -3.1
Ever had bowel cancer screening 1.1 1.3 3.2 -1.8 -1.4 0.1 0.6
Diabetes diagnosed by doctor 0.7 1.1 3.7 -1.9 0.3 -0.1 0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 2.5 -1.1 -1.6 -0.5 0.1
Friendships satisfaction 2.4 3.0 4.5 -2.1 -1.9 -1.7 -1.0
Qualifications: nursing, teaching 2.9 4.5 10.1 0.1 -2.6 -3.2 -1.0
Commuting to job workplace: Walk 1.2 1.3 4.0 0.6 0.8 0.3 2.0
Eye problems/disorders: Cataract 0.8 0.9 1.9 -0.7 -1.0 -0.6 1.4
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 1.8 1.4 1.3 0.8 -0.8
Medication for cholesterol 1.1 1.6 4.2 2.0 0.8 0.2 -1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 3.2 0.0 -1.8 -1.3 -0.2
Back pain experienced in last month 0.2 0.2 0.6 0.2 -0.2 0.5 -0.8
Mineral and other dietary supplements 0.8 1.1 1.5 0.7 1.1 1.2 -1.1
Breast cancer (self-reported) 1.5 1.8 2.6 -0.9 1.4 1.6 1.4
Asthma (self-reported) 0.4 0.8 1.4 -1.2 -0.3 1.1 -0.7
Osteoporosis (self-reported) 0.2 0.3 0.5 0.2 -0.5 -0.7 -0.5
Osteoarthritis (self-reported) 0.0 0.1 0.2 0.4 0.1 0.1 -0.2
Medication: Aspirin 1.1 1.5 2.4 -1.4 -1.5 -1.1 -0.5
Medication: Gliclazide 0.5 0.6 1.1 -1.1 0.8 0.6 -0.5
Illnesses of father: None of the above (group 1) 0.2 0.2 0.6 -0.4 -0.3 0.2 0.8
Smoking status: Current 0.6 0.9 3.1 -0.6 0.3 -0.4 1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.3 -1.0 -1.2 -0.3 0.4
Whole body water mass 0.3 1.7 5.2 -2.3 1.3 0.3 -0.1
Leg predicted mass (right) 0.4 1.9 6.4 -2.5 1.0 -0.1 -0.4
Arm fat mass (left) 0.3 1.2 2.2 -1.5 1.2 0.8 0.9
Number of self-reported non-cancer illnesses 0.6 1.1 2.6 -1.6 -0.7 -0.6 -0.9
Average weekly champagne plus white wine intake 3.7 5.1 9.7 -1.0 -2.3 -2.0 -3.1
Miserableness 1.7 3.0 6.0 0.6 1.6 1.7 2.5
Guilty feelings 0.6 0.9 2.4 -0.2 -0.9 -1.6 0.4
Wears glasses or contact lenses 0.4 0.5 0.8 0.9 0.4 0.6 0.8
Ever taken oral contraceptive pill 0.6 0.6 1.1 0.5 -0.7 -1.0 -0.8
Hearing aid user 2.3 2.6 6.8 -1.7 -0.2 -0.6 2.6
Mother’s age at death 2.3 2.8 6.7 -1.2 -1.7 -2.6 -0.5
Financial situation satisfaction 0.8 1.0 2.0 -1.4 0.8 1.1 0.2
Tinnitus: Yes, now most or all of the time 0.8 1.0 2.3 -1.5 -0.5 -1.1 0.2
Commuting to job workplace: Public transport 0.8 0.9 1.5 1.1 1.2 0.3 0.9
Eye problems/disorders: Glaucoma 2.5 2.9 6.2 -1.0 -2.5 -2.0 -0.7
Medication: Blood pressure 0.4 0.8 1.5 -0.8 0.2 0.9 1.2
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.6 1.3 0.1 -0.4 0.6
Supplements: Fish oil (including cod liver oil) 0.6 0.7 1.7 -0.1 -1.3 -0.8 0.8
High cholesterol (Self-reported) 1.3 2.4 4.1 -1.4 -2.0 -1.8 0.5
Medication: Bendroflumethiazide 1.0 1.4 1.8 -1.3 -1.4 -1.3 -0.7
Medication: Paracetamol 1.1 1.7 4.2 -1.0 1.2 2.1 0.5
Medication: Lisinopril 0.9 1.2 3.0 -0.3 1.7 1.2 -0.5
Medication: Atorvastatin 0.3 0.4 0.6 -0.6 -0.3 -0.7 -0.8
Illnesses of father: High blood pressure 0.3 0.4 0.6 0.6 0.7 0.8 0.4
Alcohol drinker status: Never 0.8 1.0 2.4 -0.2 1.2 -0.4 1.6
Ever smoked 1.0 1.8 4.1 -2.0 -0.9 -0.9 -1.2
Basal metabolic rate 0.3 1.5 4.5 -2.1 1.2 0.3 -0.2
Leg fat percentage (left) 0.3 1.1 2.5 -0.7 1.0 0.7 1.6
Arm fat-free mass (left) 0.2 1.2 2.4 -1.6 1.4 0.4 0.5
Number of operations (self-reported) 0.9 1.4 2.7 -1.6 -1.5 -0.6 -0.6
Average weekly beer plus cider intake 1.2 1.7 2.4 -1.4 1.5 1.6 0.3
Irritability 0.3 0.4 0.7 0.3 -0.9 -0.6 0.8
Risk taking 3.0 4.3 6.5 0.0 -2.3 -2.6 -2.3
Ever had prostate specific antigen (PSA) test 0.4 0.5 0.9 -0.9 -0.6 0.0 -0.7
Fractured/broken bones in last 5 years 0.5 0.6 1.3 -1.1 -0.4 0.5 0.8
Age started oral contraceptive pill 0.9 1.2 3.5 -0.8 -0.7 -1.9 0.1
Diastolic blood pressure, automated reading 1.0 3.2 4.5 1.4 2.1 2.0 1.5
Ever depressed for a whole week 0.3 0.4 0.7 -0.8 -0.8 -0.3 0.1
Unable to work because of sickness or disability 0.3 0.4 0.8 0.9 -0.9 0.0 -0.2
Commuting to job workplace: Cycle 0.4 0.5 0.9 0.1 0.8 1.0 0.5
Myopia 0.6 0.9 2.2 1.0 0.7 0.4 -1.5
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.8 1.3 -0.5 -0.9 -0.5
Cholesterol lowering medication 0.6 0.9 2.8 -1.7 -0.6 -0.5 0.2
Medication: Omeprazole (e.g. Zanprol) 1.2 1.4 3.0 -1.6 -0.4 0.1 -1.7
Pain experienced in last month 0.1 0.2 0.8 0.1 -0.2 -0.3 0.9
Supplements: Calcium 0.2 0.2 0.8 -0.1 0.2 0.2 -0.9
Basal cell carcinoma (self-reported) 0.5 0.6 1.7 0.8 -0.5 -0.0 -1.3
Heart attack/myocardial infarction (self-reported) 0.8 1.0 1.4 -0.7 -1.1 -1.2 -1.0
Deep venous thrombosis (DVT) (self-reported) 1.3 1.7 3.4 -1.2 -1.9 -1.3 0.0
Heart disease (siblings) 1.0 1.3 2.0 -0.4 1.4 1.3 1.1
Alcohol drinker status: Previous 0.2 0.3 0.7 -0.6 -0.3 -0.8 0.2
Pack years of smoking 0.9 1.3 2.1 1.5 1.1 0.1 1.3
Impedance of whole body 0.7 3.5 11.7 3.4 -0.6 -0.4 -1.4
Leg fat mass (left) 0.2 0.9 1.5 -1.2 1.1 0.6 0.9
Arm predicted mass (left) 0.3 1.5 2.9 -1.7 1.7 0.5 0.4