Hub : Genes

RAB3GAP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0400	0.0180	0.0038	0.000	0.019	-0.001	0.017	-0.001	0.37000	0.0021	0.41000	0.0029	0.55000
2	GTEx	Artery Tibial	0.0880	0.0424	0.0054	0.012	NA	-0.001	NA	0.000	0.03900	NA	0.44000	NA	0.31000
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0284	0.0161	0.0019	0.031	0.016	0.028	NA	0.032	0.00018	0.0059	0.00039	NA	0.00014
4	TCGA	Lung Squamous Cell Carcinoma	0.0362	0.0194	0.0061	0.031	0.004	0.017	NA	0.019	0.00018	0.1100	0.00380	NA	0.00300

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	2.5	3.9	7.0	0.5	-2.1	-2.6	-2.0
Bipolar Disorder or Schizophrenia	0.7	1.6	2.8	1.0	-1.3	-1.7	-1.0
Depressed Affect (Nagel 2018)	1.3	2.7	9.5	-0.6	0.5	0.7	3.1
Depression (Nagel 2018)	1.5	2.3	4.2	-1.1	-1.6	-2.0	1.0
Intelligence (Savage-Jansen 2018)	0.9	2.9	3.4	-1.6	-1.6	-1.8	-1.9
Neuroticism (Nagel 2018)	0.6	1.4	3.2	-0.3	-1.3	-0.8	1.8
Schizophrenia (2018)	0.1	0.2	0.7	0.8	0.0	-0.0	0.3
Schizophrenia vs Biploar Disorder	0.8	1.1	2.7	0.3	0.9	1.6	0.9
Worry (Nagel 2018)	0.5	1.1	2.2	-0.8	-1.5	-1.1	0.6
Alzheimer’s Disease (in mother)	1.0	1.2	2.2	-0.9	1.0	1.5	0.7
Alzheimer’s Disease (in father)	0.4	0.4	1.4	0.4	-0.0	-1.2	0.4
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	-0.0	0.9	0.6	-0.1
Crohns Disease (2017)	1.0	2.1	8.0	-2.8	-0.5	-0.4	0.1
Irritable Bowel Disease (IBD)	2.1	5.0	17.1	-4.1	-1.6	-0.4	-0.2
Ulcerative Colitis (UC)	1.7	3.3	9.4	-3.1	-1.8	-0.4	-0.5
Major Depression (MDD)	0.4	0.5	1.2	-0.2	-0.9	-1.1	-0.2
Reaction Time	0.1	0.2	0.5	-0.1	0.7	-0.2	0.5
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.3	-0.6	-1.2	-1.5	-1.1
Breast Cancer	0.9	2.2	5.4	2.3	-0.5	-0.5	-1.6
Ovarian Cancer	0.2	0.2	0.5	0.2	0.5	-0.1	0.7
Prostate Cancer	0.1	0.1	0.4	-0.2	0.2	0.7	-0.1
Age at First Birth	5.8	8.5	11.8	-2.0	-3.1	-3.4	-2.9
Bipolar Disorder (2011)	1.3	1.2	1.9	0.9	-0.7	-1.3	-1.4
Body Mass Index (BMI) (2010)	0.4	0.6	2.2	-1.5	-0.0	-0.3	0.2
Coronary Artery Disease (CAD)	0.4	0.5	1.4	0.4	-0.2	-0.5	-1.2
Crohns Disease (2012)	0.2	0.4	0.9	-0.6	0.3	0.3	0.9
Mean Putamen Volume	0.9	1.0	3.1	0.3	0.9	-0.1	-1.8
Fasting Glucose	1.8	2.2	4.6	-0.4	-2.2	-0.6	-1.9
HbA1C	0.5	0.6	1.1	-0.4	-1.0	0.5	-0.9
HDL Cholesterol	0.7	1.1	3.1	-1.8	-0.9	0.4	-0.7
LDL Cholesterol	1.0	1.5	3.7	1.0	1.2	1.9	-0.0
Lupus	0.7	1.0	1.5	-1.1	-1.1	-1.2	-0.0
Neuroticism (2016)	1.4	2.0	4.6	0.2	-1.2	-1.4	2.1
Primary Biliary Cirrhosis	1.0	1.4	3.4	0.5	-1.4	-1.9	0.0
Rheumatoid Arthritis	0.7	0.9	2.0	1.1	0.6	0.4	1.4
Schizophrenia (2014)	0.3	0.7	1.5	1.2	0.0	-0.0	1.2
Triglycerides	0.5	0.9	2.5	-0.9	-0.3	-1.6	0.4
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.7	0.3	0.8	1.3	-0.0
Ulcerative Colitis	1.2	1.7	6.0	-2.5	-0.9	0.3	-0.1
Blood Eosinophil Count	0.5	4.0	5.9	2.0	2.4	2.4	0.5
Blood Platelet Count	0.1	1.2	4.2	0.1	-2.1	-0.3	-0.6
Blood Red Count	0.0	0.4	1.1	-0.0	1.1	-0.6	0.1
Blood White Count	0.1	0.6	1.3	0.1	0.9	0.6	1.1
Heel T-Score	1.5	12.1	43.0	-6.6	-1.1	0.7	-1.9
BMI	0.2	1.1	3.4	-1.9	0.6	0.6	0.6
Height	0.1	2.0	3.8	-0.7	-0.8	-1.8	-1.9
Waist Hip Ratio (WHR)	0.1	0.6	1.6	0.2	0.2	-1.2	-0.9
Systolic Blood Pressure	0.7	3.4	5.2	1.6	1.9	2.3	1.5
Smoking Status	0.7	1.6	5.1	-2.2	-1.0	-0.4	0.2
Allergy or Eczema	0.8	2.1	3.9	0.1	-1.6	-2.0	-1.4
Cardiovascular Disease	0.1	0.5	1.4	0.3	0.4	1.2	-0.4
Hypothyroidism (self reported)	0.2	0.5	1.7	0.3	-0.4	-1.3	0.4
Respiratory disease	0.4	0.9	1.5	-0.8	-1.2	-0.2	-1.2
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.8	-0.9	0.6	0.3	0.6
Lung FEV1/FVC ratio	2.5	12.6	23.1	-4.8	-2.9	-3.3	-2.9
Lung FVC	0.4	1.9	3.9	-1.2	0.1	1.4	2.0
Neuroticism	1.3	3.1	5.9	-1.3	-2.4	-1.9	1.1
Chronotype (morning person)	0.1	0.2	0.5	0.2	0.2	-0.7	0.3
Hair Pigment	0.0	0.3	0.5	0.4	-0.6	-0.3	-0.7
Tanning	0.1	0.9	2.4	0.3	0.8	1.6	0.8
Hand grip strength (left)	0.9	2.4	3.5	-1.5	-1.4	-1.5	-1.9
Number of treatments/medications taken	1.0	1.9	6.4	-2.5	-1.0	0.1	-0.3
Average weekly spirits intake	1.0	1.2	4.4	-0.6	-0.2	0.3	2.1
Sensitivity / hurt feelings	1.4	2.4	3.4	-0.5	-1.7	-1.7	1.8
Frequency of depressed mood in last 2 weeks	1.2	1.7	2.7	-0.8	-1.2	-1.4	1.6
Hearing difficulty/problems: Yes	2.1	3.2	6.5	-2.5	-1.6	-1.3	-1.5
Relative age of first facial hair	0.8	1.7	3.9	-0.1	-0.6	1.6	2.0
Other serious medical condition/disability diagnosed by doctor	3.9	5.1	7.5	-1.4	-2.6	-2.7	-2.0
Ever used hormone-replacement therapy (HRT)	0.7	0.8	2.9	0.4	0.4	0.3	1.7
Ever had hysterectomy (womb removed)	3.2	3.6	7.1	0.0	2.7	2.4	1.3
Systolic blood pressure, automated reading	0.8	2.2	3.6	-0.9	1.0	1.9	1.9
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.6	0.6	1.3	1.1	1.1
Angina	0.3	0.4	1.0	-0.6	0.0	-0.2	1.0
Medication for hormone replacement therapy	0.5	0.5	1.3	0.1	0.6	0.7	1.1
Vitamin and mineral supplements	1.3	1.7	3.3	1.1	1.4	1.8	-0.7
Supplements: Zinc	2.2	2.4	4.2	-2.0	-1.6	-1.2	1.1
Medication: Co-codamol	0.7	0.8	2.1	-0.7	0.5	1.5	0.4
Medication: Metformin	0.5	0.7	1.8	-1.3	0.3	-0.7	0.6
Diabetes (father)	0.3	0.4	1.1	-1.0	0.5	-0.5	0.0
Diabetes (mother)	0.3	0.4	0.7	0.5	0.3	0.6	-0.8
Severe depression (siblings)	0.4	0.4	1.1	0.6	0.4	1.0	-0.3
Pack years adult smoking proportion	1.2	1.8	3.1	1.8	1.4	0.5	1.4
Impedance of leg (right)	0.7	3.5	12.5	3.5	-0.1	0.2	-1.3
Leg fat-free mass (left)	0.3	1.8	6.2	-2.5	1.0	0.0	-0.5
Trunk fat percentage	0.1	0.2	0.3	-0.6	0.6	0.3	0.4
Hand grip strength (right)	0.5	1.4	1.9	-0.8	-1.1	-1.4	-1.4
Townsend deprivation index at recruitment	1.8	2.6	7.3	0.4	1.6	0.7	2.7
Current tobacco smoking	0.9	1.4	4.9	-0.6	0.5	-0.4	2.2
Average weekly fortified wine intake	2.5	2.9	4.7	-0.9	-1.9	-2.2	-1.6
Maternal smoking around birth	1.9	2.7	5.3	-0.2	1.5	1.8	2.3
Fed-up feelings	3.0	5.5	20.6	0.1	0.6	0.9	4.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.0	-1.4	-0.9	-1.2	0.9
Relative age voice broke	1.7	2.5	5.4	0.2	0.7	2.1	2.3
Taking other prescription medications	1.5	2.3	5.3	-2.3	-1.5	-0.4	-1.1
Age when periods started (menarche)	0.7	1.6	2.2	0.2	-1.4	-1.5	-1.4
Bilateral oophorectomy (both ovaries removed)	2.9	3.4	5.5	1.7	2.0	2.3	1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	11.9	-3.5	-0.8	0.0	-1.1
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	0.5	-0.2	-0.4	0.7
Qualifications: CSEs or equivalent	2.0	2.6	4.4	-0.9	2.1	1.8	1.4
Serious illness, injury or assault to yourself	0.3	0.4	0.8	0.2	-0.7	-0.9	-0.6
High blood pressure	0.3	0.8	1.9	-1.4	0.3	0.9	0.4
Hayfever, allergic rhinitis or eczema	1.8	3.8	7.3	-0.5	-2.1	-1.8	-2.7
Multivitamins +/- minerals	0.8	1.0	2.2	-0.6	-1.0	-1.5	-0.6
Stomach or abdominal pain in last month	3.8	4.7	11.9	-3.5	-2.0	-1.3	-1.2
Supplements: Glucosamine	0.4	0.5	1.4	1.2	-0.2	-0.1	0.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.9	-0.5	0.4	0.3	0.9
Medication: Atenolol	0.4	0.5	1.3	-1.1	-0.2	0.4	0.7
Medication: Levothyroxine sodium	0.1	0.2	0.7	0.8	0.4	-0.2	-0.1
Sitting height	0.2	1.2	3.0	-0.7	0.5	-1.0	-1.7
Chronic bronchitis/emphysema (father)	2.0	2.4	3.6	1.9	1.8	1.6	0.2
High blood pressure (mother)	1.3	1.9	6.4	-2.5	-0.9	-0.2	-0.3
Body mass index (BMI)	0.5	2.1	3.3	-1.8	1.2	1.0	1.6
Impedance of leg (left)	0.7	3.6	13.7	3.7	-0.2	0.1	-0.8
Leg predicted mass (left)	0.3	1.8	6.2	-2.5	0.9	0.1	-0.5
Trunk fat mass	0.1	0.5	1.4	-1.2	0.7	0.2	0.5
Waist circumference	0.3	0.9	2.1	-1.4	0.7	-0.1	1.1
Number of incorrect matches in round	2.4	4.0	6.5	1.7	2.6	2.5	0.4
Past tobacco smoking	0.4	0.8	2.6	1.6	0.3	-0.2	0.7
Alcohol usually taken with meals	0.6	1.0	2.0	0.2	-0.9	-1.1	-1.4
Nervous feelings	0.4	0.7	1.2	0.8	0.8	0.6	1.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	0.9	0.5	-0.9	-0.9	1.0
Hearing difficulty/problems with background noise	0.6	1.0	2.6	-1.0	-0.5	-0.6	-1.6
Hair/balding pattern: Pattern 2	1.3	1.6	3.1	-1.8	-1.2	-1.4	-0.4
Had menopause	2.1	2.6	7.3	-1.0	0.9	1.1	2.7
Had other major operations	0.5	0.6	1.7	-1.3	-0.5	-0.0	0.6
Forced vital capacity (FVC)	0.1	0.4	0.9	0.8	0.1	0.4	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	8.0	-2.8	-1.0	-0.5	-1.3
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	3.5	-1.6	-1.9	-1.3	-0.0
Qualifications: None of the above	4.2	9.0	13.4	1.9	3.7	2.9	3.2
Financial difficulties in last 2 years	0.9	1.2	3.1	1.0	0.8	0.2	-1.8
Mouth/teeth dental problems	0.2	0.3	0.7	0.8	-0.6	0.2	-0.5
Heart attack	0.8	1.0	1.4	-0.8	-1.0	-1.2	-1.0
Allergy	2.7	6.2	9.9	1.8	3.1	2.2	2.7
Pain all over the body in last month	0.8	0.9	1.9	-0.6	-0.7	-0.9	-1.4
Diabetes (self-reported)	0.6	0.9	3.4	-1.8	-0.2	-0.3	0.4
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.9	0.3	-1.1	-1.1	-1.7
Medication: Ramipril	0.2	0.3	0.4	-0.6	-0.4	0.7	-0.4
Medication: Simvastatin	0.3	0.4	0.7	-0.8	-0.8	-0.2	-0.5
Fluid intelligence score	0.6	1.3	2.0	-0.9	-0.8	-1.4	-1.4
Illnesses of siblings	0.3	0.5	1.5	1.2	0.1	-0.2	-0.6
Neuroticism score	1.1	2.4	3.8	-1.2	-1.7	-1.1	1.9
Weight	0.2	1.1	2.7	-1.7	1.1	0.4	0.6
Impedance of arm (right)	0.6	2.6	6.3	2.5	-1.1	-0.9	-1.5
Arm fat percentage (right)	0.2	0.8	0.9	-0.9	0.9	0.8	0.9
Trunk fat-free mass	0.3	1.5	4.5	-2.1	1.2	0.4	-0.1
Hip circumference	0.2	0.8	2.6	-0.0	0.7	0.3	1.6
Time employed in main current job	0.6	0.7	1.7	-0.5	0.4	1.3	-0.8
Alcohol intake versus 10 years previously	0.3	0.5	1.1	-0.1	0.1	0.8	1.1
Father’s age at death	1.2	1.6	4.5	-0.4	-1.3	0.3	-2.1
Worrier / anxious feelings	2.5	4.7	8.4	-1.4	-2.9	-2.8	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.7	-0.8	0.1	-0.2	0.7
Falls in the last year	1.4	1.9	3.3	1.8	0.9	1.0	1.6
Hair/balding pattern: Pattern 3	0.5	0.7	1.4	-0.8	-0.4	-1.2	-0.7
Number of live births	0.4	0.5	1.2	1.1	-0.0	0.3	-0.9
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	3.4	-0.7	-0.8	-0.3	-1.8
Pulse rate	0.3	0.4	0.7	0.7	-0.3	-0.6	-0.9
Happiness	0.3	0.4	0.7	0.6	-0.8	-0.7	-0.3
Noisy workplace	1.8	2.2	3.5	-1.5	-1.9	-1.3	1.2
Qualifications: A levels/AS levels or equivalent	2.1	4.7	9.9	0.9	-1.5	-2.4	-3.1
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	5.1	2.3	-0.8	-0.8	-0.3
Mouth/teeth dental problems: Dentures	1.3	2.2	5.5	-1.2	1.0	0.8	2.3
Asthma	0.5	0.9	1.3	-1.1	-0.6	0.8	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.0	-1.1	-0.6	0.4	-1.4
Medication: Cholesterol lowering	0.5	0.8	1.0	-0.9	-1.0	-1.0	0.5
Depression (self-reported)	3.5	4.2	8.8	-3.0	-2.0	-1.8	1.1
Medication: Lansoprazole	0.5	0.6	1.4	0.6	1.2	0.6	0.4
Prospective memory result	1.0	1.2	3.2	-0.5	-1.0	-0.7	1.8
Lung cancer (father)	2.5	2.9	4.8	0.1	1.9	1.8	2.2
Illnesses of mother	0.3	0.4	0.6	0.8	0.7	-0.6	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	1.0	-0.2	-0.3	-0.3	-1.0
Pulse wave Arterial Stiffness index	0.8	1.0	1.8	-0.9	-0.8	-0.8	-1.3
Impedance of arm (left)	0.6	2.8	5.1	2.2	-1.5	-1.0	-1.7
Arm fat mass (right)	0.3	1.1	1.9	-1.4	1.2	0.7	0.9
Trunk predicted mass	0.3	1.5	4.1	-2.0	1.2	0.4	-0.1
Standing height	0.1	1.0	3.0	0.1	0.0	-1.0	-1.7
Length of working week for main job	0.4	0.4	0.9	0.9	0.6	0.6	-0.4
Exposure to tobacco smoke at home	0.6	0.7	1.2	-1.1	0.7	0.8	0.5
Breastfed as a baby	0.1	0.2	0.3	0.2	-0.4	-0.6	-0.5
Tense / ‘highly strung’	0.6	1.0	1.4	-0.1	-1.1	-1.2	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.2	-0.5	-0.6	0.5
Hair/balding pattern: Pattern 4	0.5	1.2	2.4	-1.2	-0.5	-0.9	-1.5
Birth weight of first child	0.7	1.3	3.4	1.8	1.1	0.4	-0.7
Peak expiratory flow (PEF)	0.4	1.0	2.5	-0.4	-0.6	1.0	-1.6
Pulse wave reflection index	0.4	0.5	1.2	-0.7	-0.6	-0.4	-1.1
Ever highly irritable/argumentative for 2 days	1.2	1.5	2.6	-1.6	-1.6	-0.2	-0.9
Loud music exposure frequency	1.2	1.3	3.5	-0.1	1.9	0.8	0.9
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	1.8	-1.3	-1.4	-1.0	-1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.4	0.2	1.2	0.8	0.5
Blood clot in the leg (DVT)	0.9	1.1	2.4	-1.1	-1.5	-1.0	0.3
Medication: Paracetamol	0.8	1.3	2.5	-1.6	0.4	1.6	-0.0
Headache pain in last month	0.3	0.5	0.9	0.1	-0.7	-1.0	-0.8
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	0.6	-0.2	-0.5	-0.4
Glaucoma (self-reported)	1.8	2.2	3.9	-0.8	-2.0	-2.0	-0.3
Gout (self-reported)	0.6	0.8	2.0	-1.4	-1.1	-0.3	0.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.5	-0.6	-0.7	-1.6	-0.1
Medication: Amlodipine	1.2	1.7	3.5	-0.1	0.8	1.6	1.9
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.0	-0.4	0.1	1.4	1.0
Birth weight	0.0	0.1	0.1	0.3	-0.2	-0.3	0.3
Chronic bronchitis/emphysema (mother)	0.8	1.0	2.5	1.1	-0.2	0.3	1.6
High blood pressure (siblings)	1.2	1.7	5.9	-2.4	-0.7	-0.3	-0.5
Forced vital capacity (FVC), Best measure	0.1	0.2	0.6	0.8	0.2	0.3	-0.3
Body fat percentage	0.1	0.4	0.5	-0.7	0.6	0.4	0.6
Leg fat percentage (right)	0.3	0.9	1.5	-0.6	1.1	0.8	1.2
Arm fat-free mass (right)	0.3	1.7	4.6	-2.1	1.4	0.4	-0.1
Exposure to tobacco smoke outside home	0.3	0.4	1.1	-0.6	0.3	0.4	1.0
Comparative body size at age 10	1.7	4.7	7.0	-2.6	-2.5	-2.0	-1.2
Number of full brothers	0.4	0.5	1.1	1.1	-0.3	0.5	-0.6
Worry too long after embarrassment	1.3	2.2	4.5	0.3	-2.1	-2.1	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.4	3.4	-0.3	-1.9	-1.3	-0.3
Wheeze or whistling in the chest in last year	0.4	0.7	2.3	-1.5	-0.2	0.6	0.1
Number of children fathered	0.0	0.1	0.1	0.2	0.3	0.0	0.3
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.4	4.0	2.0	1.8	1.5	-0.3
Age at first live birth	3.2	5.7	8.7	0.3	-2.9	-2.9	-2.4
Pulse wave peak to peak time	0.7	0.9	1.4	1.0	0.7	0.7	1.2
Health satisfaction	2.9	3.7	6.3	-2.5	-2.0	-1.3	-1.7
Shortness of breath walking on level ground	2.3	2.7	7.8	-2.8	-1.7	-0.3	-0.3
Qualifications: College or University degree	2.7	8.6	18.8	0.0	-2.6	-3.0	-4.3
Eye problems/disorders: None of the above	2.0	2.3	3.2	1.4	1.8	1.2	-1.6
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.8	-0.9	-0.6	-0.8	-0.9
Emphysema/chronic bronchitis	0.5	0.6	1.8	0.2	-0.7	-1.4	-0.3
Medication for pain relief, constipation, heartburn	1.1	1.9	4.8	2.2	1.4	-0.1	1.0
Neck or shoulder pain in last month	0.1	0.1	0.2	-0.5	-0.4	-0.0	-0.1
Medication: Blood pressure	0.2	0.3	0.6	-0.5	0.3	0.8	-0.2
Angina (self-reported)	0.4	0.6	1.4	-0.8	-0.2	-0.5	1.2
Migraine (self-reported)	0.2	0.3	0.6	-0.8	-0.5	-0.2	-0.5
Medication: Ibuprofen	0.6	0.7	1.1	-1.1	-0.9	-0.1	-0.8
Medication: Allopurinol	0.2	0.3	0.9	-1.0	-0.2	0.4	-0.2
Medication: Omeprazole	1.4	1.7	3.7	-1.6	-0.5	-0.1	-1.9
Medication: Seretide 50 evohaler	0.2	0.2	0.7	-0.4	-0.2	-0.2	-0.9
Mean time to correctly identify matches	0.4	0.8	2.0	-0.6	1.0	0.2	1.4
Heart disease (mother)	0.5	0.7	1.5	-1.2	0.1	0.1	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.4	0.3	-0.4	-0.0	-0.7
Whole body fat mass	0.2	0.8	1.6	-1.3	1.0	0.5	0.6
Leg fat mass (right)	0.3	1.0	1.7	-1.3	1.2	0.7	0.7
Arm predicted mass (right)	0.3	1.7	4.0	-2.0	1.6	0.6	0.0
Pulse rate, automated reading	0.3	0.9	1.8	0.9	-0.4	-0.9	-1.3
Alcohol intake frequency.	0.2	0.5	1.1	-0.3	1.1	0.4	0.9
Comparative height size at age 10	0.4	1.9	2.7	0.9	1.5	1.4	1.6
Number of full sisters	0.3	0.3	0.6	-0.7	-0.4	0.6	-0.5
Suffer from ‘nerves’	0.3	0.4	0.8	-0.9	0.1	0.5	0.8
Overall health rating	0.3	0.7	2.0	-1.4	-0.1	-0.0	-0.9
Chest pain or discomfort	0.7	1.0	2.8	-1.7	0.4	1.0	0.2
Had major operations	0.6	0.7	1.9	0.1	-0.9	0.3	-1.4
Age at last live birth	4.3	6.3	11.1	0.9	-2.6	-3.3	-2.5
Family relationship satisfaction	0.2	0.2	0.5	-0.7	-0.1	0.3	-0.4
Leg pain on walking	1.1	1.4	3.2	-1.2	-0.8	0.4	-1.8
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.5	0.1	0.2	-0.1	0.7
Commuting to job workplace: Car/motor vehicle	2.0	2.3	3.9	-1.4	-2.0	-1.4	-1.2
Illness, injury, bereavement, stress in last 2 years	2.4	2.9	9.2	-3.0	-0.6	-0.4	-1.4
Medication: Aspirin	0.6	0.8	1.4	-0.8	-1.2	-0.9	-0.6
Supplements: Vitamin C	2.1	2.5	3.9	-2.0	-1.1	-1.4	1.7
Knee pain experienced in last month	0.9	1.4	3.5	-1.9	0.9	1.1	-0.0
Hypertension (Self-reported)	0.3	0.8	1.2	-1.0	0.5	1.1	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.5	-1.6	0.6	0.6	0.7
Illnesses of father: Heart disease	0.2	0.3	0.4	0.6	-0.5	-0.4	-0.6
Illnesses of siblings: Diabetes	1.0	1.2	4.1	-2.0	-0.9	-0.1	-0.3
Smoking status: Previous	0.7	1.0	2.9	-1.7	0.2	1.0	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.5	0.3	-0.3	-0.1	-1.9
Whole body fat-free mass	0.3	1.7	5.1	-2.3	1.3	0.3	-0.2
Leg fat-free mass (right)	0.3	1.9	6.4	-2.5	1.0	-0.1	-0.3
Arm fat percentage (left)	0.2	0.8	1.4	-1.2	0.8	0.7	0.8
Average weekly red wine intake	0.6	0.9	1.7	0.9	-0.4	-1.3	0.9
Handedness (chirality/laterality): Left-handed	3.2	3.9	6.8	-2.0	-2.6	-2.0	-0.8
Mood swings	1.3	2.3	6.5	0.3	1.0	1.3	2.6
Loneliness, isolation	1.4	2.0	6.1	-1.1	-0.7	-0.5	2.5
Long-standing illness, disability or infirmity	2.6	4.0	9.8	-1.7	-1.6	-1.0	-3.1
Ever had bowel cancer screening	1.1	1.3	3.2	-1.8	-1.4	0.1	0.6
Diabetes diagnosed by doctor	0.7	1.1	3.7	-1.9	0.3	-0.1	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.5	-1.1	-1.6	-0.5	0.1
Friendships satisfaction	2.4	3.0	4.5	-2.1	-1.9	-1.7	-1.0
Qualifications: nursing, teaching	2.9	4.5	10.1	0.1	-2.6	-3.2	-1.0
Commuting to job workplace: Walk	1.2	1.3	4.0	0.6	0.8	0.3	2.0
Eye problems/disorders: Cataract	0.8	0.9	1.9	-0.7	-1.0	-0.6	1.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	1.8	1.4	1.3	0.8	-0.8
Medication for cholesterol	1.1	1.6	4.2	2.0	0.8	0.2	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.2	0.0	-1.8	-1.3	-0.2
Back pain experienced in last month	0.2	0.2	0.6	0.2	-0.2	0.5	-0.8
Mineral and other dietary supplements	0.8	1.1	1.5	0.7	1.1	1.2	-1.1
Breast cancer (self-reported)	1.5	1.8	2.6	-0.9	1.4	1.6	1.4
Asthma (self-reported)	0.4	0.8	1.4	-1.2	-0.3	1.1	-0.7
Osteoporosis (self-reported)	0.2	0.3	0.5	0.2	-0.5	-0.7	-0.5
Osteoarthritis (self-reported)	0.0	0.1	0.2	0.4	0.1	0.1	-0.2
Medication: Aspirin	1.1	1.5	2.4	-1.4	-1.5	-1.1	-0.5
Medication: Gliclazide	0.5	0.6	1.1	-1.1	0.8	0.6	-0.5
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	-0.4	-0.3	0.2	0.8
Smoking status: Current	0.6	0.9	3.1	-0.6	0.3	-0.4	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.3	-1.0	-1.2	-0.3	0.4
Whole body water mass	0.3	1.7	5.2	-2.3	1.3	0.3	-0.1
Leg predicted mass (right)	0.4	1.9	6.4	-2.5	1.0	-0.1	-0.4
Arm fat mass (left)	0.3	1.2	2.2	-1.5	1.2	0.8	0.9
Number of self-reported non-cancer illnesses	0.6	1.1	2.6	-1.6	-0.7	-0.6	-0.9
Average weekly champagne plus white wine intake	3.7	5.1	9.7	-1.0	-2.3	-2.0	-3.1
Miserableness	1.7	3.0	6.0	0.6	1.6	1.7	2.5
Guilty feelings	0.6	0.9	2.4	-0.2	-0.9	-1.6	0.4
Wears glasses or contact lenses	0.4	0.5	0.8	0.9	0.4	0.6	0.8
Ever taken oral contraceptive pill	0.6	0.6	1.1	0.5	-0.7	-1.0	-0.8
Hearing aid user	2.3	2.6	6.8	-1.7	-0.2	-0.6	2.6
Mother’s age at death	2.3	2.8	6.7	-1.2	-1.7	-2.6	-0.5
Financial situation satisfaction	0.8	1.0	2.0	-1.4	0.8	1.1	0.2
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.3	-1.5	-0.5	-1.1	0.2
Commuting to job workplace: Public transport	0.8	0.9	1.5	1.1	1.2	0.3	0.9
Eye problems/disorders: Glaucoma	2.5	2.9	6.2	-1.0	-2.5	-2.0	-0.7
Medication: Blood pressure	0.4	0.8	1.5	-0.8	0.2	0.9	1.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.6	1.3	0.1	-0.4	0.6
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.7	-0.1	-1.3	-0.8	0.8
High cholesterol (Self-reported)	1.3	2.4	4.1	-1.4	-2.0	-1.8	0.5
Medication: Bendroflumethiazide	1.0	1.4	1.8	-1.3	-1.4	-1.3	-0.7
Medication: Paracetamol	1.1	1.7	4.2	-1.0	1.2	2.1	0.5
Medication: Lisinopril	0.9	1.2	3.0	-0.3	1.7	1.2	-0.5
Medication: Atorvastatin	0.3	0.4	0.6	-0.6	-0.3	-0.7	-0.8
Illnesses of father: High blood pressure	0.3	0.4	0.6	0.6	0.7	0.8	0.4
Alcohol drinker status: Never	0.8	1.0	2.4	-0.2	1.2	-0.4	1.6
Ever smoked	1.0	1.8	4.1	-2.0	-0.9	-0.9	-1.2
Basal metabolic rate	0.3	1.5	4.5	-2.1	1.2	0.3	-0.2
Leg fat percentage (left)	0.3	1.1	2.5	-0.7	1.0	0.7	1.6
Arm fat-free mass (left)	0.2	1.2	2.4	-1.6	1.4	0.4	0.5
Number of operations (self-reported)	0.9	1.4	2.7	-1.6	-1.5	-0.6	-0.6
Average weekly beer plus cider intake	1.2	1.7	2.4	-1.4	1.5	1.6	0.3
Irritability	0.3	0.4	0.7	0.3	-0.9	-0.6	0.8
Risk taking	3.0	4.3	6.5	0.0	-2.3	-2.6	-2.3
Ever had prostate specific antigen (PSA) test	0.4	0.5	0.9	-0.9	-0.6	0.0	-0.7
Fractured/broken bones in last 5 years	0.5	0.6	1.3	-1.1	-0.4	0.5	0.8
Age started oral contraceptive pill	0.9	1.2	3.5	-0.8	-0.7	-1.9	0.1
Diastolic blood pressure, automated reading	1.0	3.2	4.5	1.4	2.1	2.0	1.5
Ever depressed for a whole week	0.3	0.4	0.7	-0.8	-0.8	-0.3	0.1
Unable to work because of sickness or disability	0.3	0.4	0.8	0.9	-0.9	0.0	-0.2
Commuting to job workplace: Cycle	0.4	0.5	0.9	0.1	0.8	1.0	0.5
Myopia	0.6	0.9	2.2	1.0	0.7	0.4	-1.5
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.8	1.3	-0.5	-0.9	-0.5
Cholesterol lowering medication	0.6	0.9	2.8	-1.7	-0.6	-0.5	0.2
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	3.0	-1.6	-0.4	0.1	-1.7
Pain experienced in last month	0.1	0.2	0.8	0.1	-0.2	-0.3	0.9
Supplements: Calcium	0.2	0.2	0.8	-0.1	0.2	0.2	-0.9
Basal cell carcinoma (self-reported)	0.5	0.6	1.7	0.8	-0.5	-0.0	-1.3
Heart attack/myocardial infarction (self-reported)	0.8	1.0	1.4	-0.7	-1.1	-1.2	-1.0
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	3.4	-1.2	-1.9	-1.3	0.0
Heart disease (siblings)	1.0	1.3	2.0	-0.4	1.4	1.3	1.1
Alcohol drinker status: Previous	0.2	0.3	0.7	-0.6	-0.3	-0.8	0.2
Pack years of smoking	0.9	1.3	2.1	1.5	1.1	0.1	1.3
Impedance of whole body	0.7	3.5	11.7	3.4	-0.6	-0.4	-1.4
Leg fat mass (left)	0.2	0.9	1.5	-1.2	1.1	0.6	0.9
Arm predicted mass (left)	0.3	1.5	2.9	-1.7	1.7	0.5	0.4